{
  "ptid_time": "027_S_0835_2009-09-16",
  "img_path": "/data/qiuhui/data/adni/images/027_S_0835/2009-09-16/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 41,121 mm³, 6.8% above the reference mean. With a Z-score of 0.16 (56.4th percentile), this represents normal volume ; hippocampal volume measures 5,619 mm³, 25.7% below the reference mean. With a Z-score of -2.50 (0.6th percentile), this represents significant atrophy; whole brain volume measures 1,091,900 mm³, 1.2% above the reference mean. With a Z-score of 0.15 (56.0th percentile), this represents normal volume ; entorhinal cortex volume measures 2,499 mm³, 39.1% below the reference mean. With a Z-score of -2.65 (0.4th percentile), this represents significant atrophy; fusiform gyrus volume measures 15,609 mm³, 17.1% below the reference mean. With a Z-score of -1.46 (7.2th percentile), this represents mild atrophy; middle temporal gyrus volume measures 19,220 mm³, 9.9% below the reference mean. With a Z-score of -0.89 (18.6th percentile), this represents normal volume . ",
  "text_data": "Age is 75.7 years. Gender is Male. Education: 14 years. MMSE: 22.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 572.00 pg/mL (mild reduced); Total tau: 298.00 pg/mL (normal ); Phosphorylated tau: 29.69 pg/mL (mild elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The patient shows significant atrophy in the hippocampus and entorhinal cortex, both key regions affected in Alzheimer's disease (AD), along with mild fusiform gyrus atrophy. The MMSE score of 22 suggests cognitive impairment, and the presence of APOE4, mildly reduced Aβ, and mildly elevated P-tau further support AD pathology.  \n\n**Diagnosis:** Dementia (likely Alzheimer’s disease)  \n**Confidence:** High",
  "timestamp": "2025-07-26T03:42:55.183161"
}