{
  "ptid_time": "003_S_4136_2011-08-10",
  "img_path": "/data/qiuhui/data/adni/images/003_S_4136/2011-08-10/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 134,953 mm³, 349.5% above the reference mean. With a Z-score of 8.30 (100.0th percentile), this represents profound enlargement; hippocampal volume measures 6,388 mm³, 20.4% below the reference mean. With a Z-score of -2.04 (2.1th percentile), this represents significant atrophy; whole brain volume measures 1,215,770 mm³, 7.2% above the reference mean. With a Z-score of 1.01 (84.5th percentile), this represents mild enlargement; entorhinal cortex volume measures 3,309 mm³, 22.4% below the reference mean. With a Z-score of -1.55 (6.1th percentile), this represents moderate atrophy; fusiform gyrus volume measures 19,636 mm³, 1.4% below the reference mean. With a Z-score of -0.11 (45.5th percentile), this represents normal volume ; middle temporal gyrus volume measures 20,067 mm³, 10.5% below the reference mean. With a Z-score of -0.86 (19.4th percentile), this represents normal volume . ",
  "text_data": "Age is 66.7 years. Gender is Male. Education: 20 years. Handedness: Left. Race: White. Medical history: Major Surgical Procedures. MMSE: 24.0. MoCA: 19.0. Logical Memory: 6.0. Laboratory findings: Basophils: 0.12 (profound elevated); Basophils: 2.10 (profound elevated). APOEε4 alleles: 1.0. Biomarker levels: Florbetapir (AV45): 1.53 SUVR (profound elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound ventricular enlargement (349.5% above mean, Z=8.30) and significant hippocampal atrophy (20.4% below mean, Z=-2.04), along with moderate entorhinal cortex atrophy (22.4% below mean, Z=-1.55). These findings, combined with cognitive test scores (MMSE=24, MoCA=19) below normal thresholds and a positive APOE4 allele, strongly suggest neurodegenerative pathology. The AV45 (amyloid PET) result of \"profound elevated\" further supports Alzheimer's disease.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-25T20:50:07.259000"
}