{
  "ptid_time": "005_S_0572_2009-07-06",
  "img_path": "/data/qiuhui/data/adni/images/005_S_0572/2009-07-06/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 73,535 mm³, 56.4% above the reference mean. With a Z-score of 1.64 (94.9th percentile), this represents moderate enlargement; whole brain volume measures 871,728 mm³, 15.3% below the reference mean. With a Z-score of -2.00 (2.3th percentile), this represents significant atrophy. ",
  "text_data": "Age is 81.7 years. Gender is Male. Education: 14 years. MMSE: 26.0. Logical Memory: 0.0. APOEε4 alleles: 2.0. ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows significant whole brain atrophy (Z-score -2.00, 2.3rd percentile) and moderate ventricular enlargement (Z-score 1.64, 94.9th percentile), which are strong indicators of neurodegeneration. Combined with advanced age, APOE4 homozygosity (high genetic risk), and an MMSE score of 26 (borderline normal/mild impairment), this suggests cognitive decline beyond normal aging.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI)** (likely prodromal Alzheimer’s given APOE4 status and atrophy pattern).  \n\n**Confidence:** **Medium-High** (MMSE is near-normal, but structural changes and genetic risk strongly support MCI/early dementia).  \n\n*(Note: If additional biomarkers like CSF Aβ/tau or amyloid PET were available, confidence could increase further.)*",
  "timestamp": "2025-07-25T21:12:18.850816"
}