{
  "ptid_time": "127_S_5067_2013-02-04",
  "img_path": "/data/qiuhui/data/adni/images/127_S_5067/2013-02-04/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 40,595 mm³, 13.7% below the reference mean. With a Z-score of -0.40 (34.6th percentile), this represents normal volume ; hippocampal volume measures 4,331 mm³, 37.8% below the reference mean. With a Z-score of -3.27 (0.1th percentile), this represents profound atrophy; whole brain volume measures 997,996 mm³, 3.0% below the reference mean. With a Z-score of -0.40 (34.6th percentile), this represents normal volume . ",
  "text_data": "Age is 80.6 years. Gender is Male. Education: 13 years. Handedness: Right. Race: White. Medical history: Head, Eyes, Ears, Nose and Throat; Dermatologic-Connective Tissue; Musculoskeletal; Endocrine-Metabolic; Gastrointestinal; Renal-Genitourinary; Malignancy; Major Surgical Procedures. MMSE: 23.0. MoCA: 18.0. Logical Memory: 1.0. Laboratory findings: Monocytes: 1.04 (profound elevated); Eosinophils: 0.47 (profound elevated); Monocytes: 12.00 (profound elevated); Eosinophils: 5.40 (significant elevated). APOEε4 alleles: 0.0. Biomarker levels: Florbetapir (AV45): 0.94 SUVR (mild reduced); Total tau: 851.60 pg/mL (profound elevated); Phosphorylated tau: 77.85 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "Reasoning: The hippocampal volume shows profound atrophy (Z-score -3.27, 0.1th percentile), which is strongly indicative of neurodegeneration. Combined with elevated T-tau and P-tau (markers of neuronal injury and amyloid pathology) and mild amyloid reduction (AV45), this suggests Alzheimer's pathology. The cognitive scores (MMSE 23, MoCA 18) are consistent with cognitive impairment but not severe dementia.  \nDiagnosis: **MCI (likely due to Alzheimer's disease)**  \nConfidence: **High**",
  "timestamp": "2025-07-26T13:25:22.872366"
}