{
  "ptid_time": "128_S_0310_2007-04-23",
  "img_path": "/data/qiuhui/data/adni/images/128_S_0310/2007-04-23/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 60,848 mm³, 29.4% above the reference mean. With a Z-score of 0.85 (80.4th percentile), this represents normal volume ; hippocampal volume measures 4,096 mm³, 41.2% below the reference mean. With a Z-score of -3.56 (0.0th percentile), this represents profound atrophy; whole brain volume measures 882,514 mm³, 14.2% below the reference mean. With a Z-score of -1.87 (3.1th percentile), this represents moderate atrophy; entorhinal cortex volume measures 2,776 mm³, 30.1% below the reference mean. With a Z-score of -1.97 (2.5th percentile), this represents moderate atrophy; fusiform gyrus volume measures 12,438 mm³, 31.2% below the reference mean. With a Z-score of -2.70 (0.3th percentile), this represents significant atrophy; middle temporal gyrus volume measures 13,597 mm³, 32.6% below the reference mean. With a Z-score of -2.92 (0.2th percentile), this represents significant atrophy. ",
  "text_data": "Age is 83.7 years. Gender is Male. Education: 16 years. MMSE: 24.0. Logical Memory: 4.0. APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 684.10 pg/mL (normal ); Total tau: 456.40 pg/mL (significant elevated); Phosphorylated tau: 52.43 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound hippocampal atrophy (Z-score -3.56) and significant atrophy in the fusiform gyrus and middle temporal gyrus, which are key regions affected in Alzheimer's disease. Elevated T-tau and P-tau with normal Aβ suggest a tauopathy, likely Alzheimer's pathology, despite the absence of APOE4. The MMSE score of 24 is borderline but aligns with cognitive impairment.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T13:45:06.013180"
}