{
  "ptid_time": "027_S_0256_2009-04-06",
  "img_path": "/data/qiuhui/data/adni/images/027_S_0256/2009-04-06/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 58,279 mm³, 51.3% above the reference mean. With a Z-score of 1.23 (89.0th percentile), this represents mild enlargement; hippocampal volume measures 4,704 mm³, 37.8% below the reference mean. With a Z-score of -3.68 (0.0th percentile), this represents profound atrophy; whole brain volume measures 974,981 mm³, 9.7% below the reference mean. With a Z-score of -1.26 (10.5th percentile), this represents mild atrophy; entorhinal cortex volume measures 2,705 mm³, 34.0% below the reference mean. With a Z-score of -2.31 (1.0th percentile), this represents significant atrophy; fusiform gyrus volume measures 16,012 mm³, 15.0% below the reference mean. With a Z-score of -1.28 (10.1th percentile), this represents mild atrophy; middle temporal gyrus volume measures 15,066 mm³, 29.4% below the reference mean. With a Z-score of -2.64 (0.4th percentile), this represents significant atrophy. ",
  "text_data": "Age is 73.1 years. Gender is Male. Education: 20 years. MMSE: 16.0. Logical Memory: 2.0. APOEε4 alleles: 2.0. Biomarker levels: Amyloid beta: 232.10 pg/mL (significant reduced); Total tau: 232.90 pg/mL (normal ); Phosphorylated tau: 21.80 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "Reasoning: The data shows profound hippocampal atrophy (Z-score -3.68, 0.0th percentile), significant entorhinal cortex and middle temporal gyrus atrophy, and mild whole brain atrophy. Combined with a low MMSE score (16.0) and significant Aβ reduction (indicative of amyloid pathology), this strongly suggests Alzheimer's disease. The presence of two APOE4 alleles further supports this diagnosis.  \nDiagnosis: Dementia (likely Alzheimer's disease)  \nConfidence: High",
  "timestamp": "2025-07-26T03:32:21.831227"
}