{
  "ptid_time": "002_S_1268_2011-04-13",
  "img_path": "/data/qiuhui/data/adni/images/002_S_1268/2011-04-13/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 87,514 mm³, 86.1% above the reference mean. With a Z-score of 2.50 (99.4th percentile), this represents significant enlargement; hippocampal volume measures 5,666 mm³, 18.7% below the reference mean. With a Z-score of -1.61 (5.3th percentile), this represents moderate atrophy; whole brain volume measures 1,008,410 mm³, 2.0% below the reference mean. With a Z-score of -0.26 (39.6th percentile), this represents normal volume ; entorhinal cortex volume measures 3,392 mm³, 14.5% below the reference mean. With a Z-score of -0.95 (17.1th percentile), this represents normal volume ; fusiform gyrus volume measures 16,909 mm³, 6.4% below the reference mean. With a Z-score of -0.55 (29.0th percentile), this represents normal volume ; middle temporal gyrus volume measures 18,951 mm³, 6.1% below the reference mean. With a Z-score of -0.54 (29.4th percentile), this represents normal volume . ",
  "text_data": "Age is 86.7 years. Gender is Male. Education: 20 years. Handedness: Unknown. Race: Unknown. Medical history: Psychiatric; Head, Eyes, Ears, Nose and Throat; Cardiovascular; Hepatic; Musculoskeletal; Endocrine-Metabolic; Smoking. MMSE: 27.0. MoCA: 23.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Florbetapir (AV45): 1.57 SUVR (profound elevated); Amyloid beta: 546.80 pg/mL (mild reduced); Total tau: 334.30 pg/mL (mild elevated); Phosphorylated tau: 16.51 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "Reasoning: The data shows significant ventricular enlargement (Z-score 2.50) and moderate hippocampal atrophy (Z-score -1.61), both indicative of neurodegeneration. The MMSE of 27 is borderline normal, but the MoCA of 23 suggests mild cognitive impairment, supported by mildly reduced Aβ and elevated T-tau with profound AV45 elevation (indicating amyloid pathology).  \nDiagnosis: **MCI** (likely prodromal Alzheimer’s given biomarker profile)  \nConfidence: **High**",
  "timestamp": "2025-07-25T20:15:50.170482"
}