{
  "ptid_time": "130_S_4925_2014-10-10",
  "img_path": "/data/qiuhui/data/adni/images/130_S_4925/2014-10-10/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 94,581 mm³, 145.6% above the reference mean. With a Z-score of 3.49 (100.0th percentile), this represents profound enlargement; hippocampal volume measures 6,294 mm³, 16.7% below the reference mean. With a Z-score of -1.63 (5.1th percentile), this represents moderate atrophy; whole brain volume measures 1,056,100 mm³, 2.2% below the reference mean. With a Z-score of -0.28 (39.0th percentile), this represents normal volume ; entorhinal cortex volume measures 3,706 mm³, 9.6% below the reference mean. With a Z-score of -0.65 (25.7th percentile), this represents normal volume ; fusiform gyrus volume measures 17,235 mm³, 8.5% below the reference mean. With a Z-score of -0.73 (23.4th percentile), this represents normal volume ; middle temporal gyrus volume measures 18,464 mm³, 13.5% below the reference mean. With a Z-score of -1.21 (11.3th percentile), this represents mild atrophy. ",
  "text_data": "Age is 77.0 years. Gender is Male. Education: 12 years. MMSE: 16.0. MoCA: 13.0. Logical Memory: 1.0. APOEε4 alleles: 0.0. Biomarker levels: Florbetapir (AV45): 1.75 SUVR (profound elevated); Amyloid beta: 551.00 pg/mL (mild reduced); Total tau: 281.80 pg/mL (normal ); Phosphorylated tau: 30.82 pg/mL (mild elevated). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows profound ventricular enlargement (Z-score 3.49) and moderate hippocampal atrophy (Z-score -1.63), both strong indicators of neurodegeneration. Combined with significantly reduced MMSE (16) and MoCA (13) scores, elevated AV45 (amyloid PET), and mild Aβ reduction with elevated P-tau, this strongly suggests Alzheimer’s pathology.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T14:54:07.750430"
}