{
  "ptid_time": "027_S_1081_2007-01-22",
  "img_path": "/data/qiuhui/data/adni/images/027_S_1081/2007-01-22/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 76,209 mm³, 62.1% above the reference mean. With a Z-score of 1.80 (96.4th percentile), this represents moderate enlargement; whole brain volume measures 941,319 mm³, 8.5% below the reference mean. With a Z-score of -1.12 (13.2th percentile), this represents mild atrophy. ",
  "text_data": "Age is 84.5 years. Gender is Male. Education: 20 years. Handedness: Right. Race: White. Medical history: Psychiatric; Head, Eyes, Ears, Nose and Throat; Cardiovascular; Dermatologic-Connective Tissue; Endocrine-Metabolic; Gastrointestinal; Hematopoietic-Lymphatic; Major Surgical Procedures. MMSE: 23.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 596.00 pg/mL (mild reduced); Total tau: 391.60 pg/mL (moderate elevated); Phosphorylated tau: 37.49 pg/mL (significant elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows moderate ventricular enlargement and mild whole brain atrophy, which are structural changes often seen in neurodegenerative conditions. Combined with elevated tau biomarkers (moderate T-tau and significant P-tau), mild Aβ reduction, and an MMSE score of 23 (borderline impaired), this suggests cognitive decline beyond normal aging.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI)** (likely progressing toward Alzheimer’s disease given biomarker profile).  \n\n**Confidence:** **Medium** (clinical correlation needed to rule out other causes of tau elevation, but biomarkers and imaging strongly support MCI due to Alzheimer’s pathology).",
  "timestamp": "2025-07-26T03:45:42.233251"
}