{
  "ptid_time": "033_S_1279_2008-02-29",
  "img_path": "/data/qiuhui/data/adni/images/033_S_1279/2008-02-29/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 13,478 mm³, 39.7% below the reference mean. With a Z-score of -0.99 (16.0th percentile), this represents normal volume ; hippocampal volume measures 5,854 mm³, 23.8% below the reference mean. With a Z-score of -2.67 (0.4th percentile), this represents significant atrophy; whole brain volume measures 1,034,240 mm³, 0.5% above the reference mean. With a Z-score of 0.06 (52.4th percentile), this represents normal volume ; entorhinal cortex volume measures 3,020 mm³, 22.4% below the reference mean. With a Z-score of -1.74 (4.1th percentile), this represents moderate atrophy; fusiform gyrus volume measures 16,421 mm³, 9.8% below the reference mean. With a Z-score of -1.11 (13.4th percentile), this represents mild atrophy; middle temporal gyrus volume measures 21,888 mm³, 6.7% above the reference mean. With a Z-score of 0.59 (72.3th percentile), this represents normal volume . ",
  "text_data": "Age is 69.3 years. Gender is Female. Education: 16 years. MMSE: 29.0. Logical Memory: 13.0. Laboratory findings: Vitamin B12: 930.00 (significant elevated); Cholesterol (High Performance): 276.00 (significant elevated). APOEε4 alleles: 2.0. ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "Reasoning: The hippocampal volume shows significant atrophy (Z-score -2.67, 0.4th percentile), and the entorhinal cortex has moderate atrophy (Z-score -1.74, 4.1th percentile), both of which are key biomarkers for Alzheimer's pathology. However, the MMSE score of 29 is within the normal range, and whole brain volume is normal, suggesting preserved cognitive function despite structural changes.  \n\nDiagnosis: **MCI (Mild Cognitive Impairment)**  \nConfidence: **Medium**  \n\n(While the structural atrophy is concerning, the lack of significant cognitive decline on MMSE makes dementia less likely. The presence of two APOE4 alleles increases Alzheimer's risk, supporting MCI as a probable transitional stage.)",
  "timestamp": "2025-07-26T05:31:24.331261"
}