{
  "ptid_time": "130_S_0783_2006-08-17",
  "img_path": "/data/qiuhui/data/adni/images/130_S_0783/2006-08-17/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 39,315 mm³, 40.1% above the reference mean. With a Z-score of 0.92 (82.1th percentile), this represents normal volume ; hippocampal volume measures 6,284 mm³, 11.7% below the reference mean. With a Z-score of -1.07 (14.2th percentile), this represents mild atrophy; whole brain volume measures 978,282 mm³, 0.4% above the reference mean. With a Z-score of 0.05 (51.9th percentile), this represents normal volume ; entorhinal cortex volume measures 2,449 mm³, 33.3% below the reference mean. With a Z-score of -2.05 (2.0th percentile), this represents significant atrophy; fusiform gyrus volume measures 14,886 mm³, 12.5% below the reference mean. With a Z-score of -1.14 (12.8th percentile), this represents mild atrophy; middle temporal gyrus volume measures 18,581 mm³, 3.1% below the reference mean. With a Z-score of -0.27 (39.5th percentile), this represents normal volume . ",
  "text_data": "Age is 79.2 years. Gender is Female. Education: 18 years. Handedness: Right. Race: White. Medical history: Psychiatric; Neurologic; Cardiovascular; Malignancy; Major Surgical Procedures. MMSE: 29.0. Logical Memory: 5.0. APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 1038.00 pg/mL (normal ); Total tau: 246.50 pg/mL (normal ); Phosphorylated tau: 22.19 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The patient shows significant atrophy in the entorhinal cortex (Z-score -2.05, 2.0th percentile) and mild atrophy in the hippocampus (Z-score -1.07, 14.2th percentile) and fusiform gyrus (Z-score -1.14, 12.8th percentile), which are regions commonly affected in early Alzheimer's disease. However, cognitive performance (MMSE 29/30) and CSF biomarkers (Aβ, T-tau, P-tau) are normal, suggesting no current dementia or significant cognitive impairment.  \n\n**Diagnosis:** **CN (Cognitively Normal)**  \n**Confidence:** **Medium** (due to conflicting structural atrophy and normal biomarkers/cognition)",
  "timestamp": "2025-07-26T14:30:52.286949"
}