{
  "ptid_time": "023_S_1262_2008-04-02",
  "img_path": "/data/qiuhui/data/adni/images/023_S_1262/2008-04-02/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 41,184 mm³, 46.7% above the reference mean. With a Z-score of 1.07 (85.8th percentile), this represents mild enlargement; hippocampal volume measures 4,573 mm³, 35.7% below the reference mean. With a Z-score of -3.28 (0.1th percentile), this represents profound atrophy; whole brain volume measures 824,204 mm³, 15.4% below the reference mean. With a Z-score of -1.94 (2.6th percentile), this represents moderate atrophy; entorhinal cortex volume measures 1,910 mm³, 48.0% below the reference mean. With a Z-score of -2.95 (0.2th percentile), this represents significant atrophy; fusiform gyrus volume measures 11,771 mm³, 30.8% below the reference mean. With a Z-score of -2.80 (0.3th percentile), this represents significant atrophy; middle temporal gyrus volume measures 14,707 mm³, 23.3% below the reference mean. With a Z-score of -2.02 (2.2th percentile), this represents significant atrophy. ",
  "text_data": "Age is 73.7 years. Gender is Female. Education: 12 years. MMSE: 13.0. Logical Memory: 0.0. Laboratory findings: Monocytes: 1.34 (profound elevated); Basophils: 0.00 (significant reduced); WBC: 14.90 (profound elevated); Neutrophils: 10.88 (profound elevated); Total Bilirubin: 1.30 (profound elevated); Direct Bilirubin: 0.30 (significant elevated); GGT: 49.00 (profound elevated); Serum Uric Acid: 2.40 (significant reduced). APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 550.70 pg/mL (mild reduced); Total tau: 473.90 pg/mL (significant elevated); Phosphorylated tau: 48.00 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound hippocampal atrophy (Z-score -3.28), significant entorhinal cortex and fusiform gyrus atrophy, and elevated tau biomarkers (T-tau and P-tau), which are strongly indicative of Alzheimer's pathology. The MMSE score of 13.0, combined with these structural and biomarker findings, suggests severe cognitive impairment.  \n\n**Diagnosis:** **Dementia** (likely Alzheimer’s disease)  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T02:57:49.382451"
}