{
  "ptid_time": "022_S_2087_2014-10-21",
  "img_path": "/data/qiuhui/data/adni/images/022_S_2087/2014-10-21/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 31,001 mm³, 19.5% below the reference mean. With a Z-score of -0.47 (32.0th percentile), this represents normal volume ; hippocampal volume measures 7,521 mm³, 0.5% below the reference mean. With a Z-score of -0.05 (48.0th percentile), this represents normal volume ; whole brain volume measures 1,050,760 mm³, 2.7% below the reference mean. With a Z-score of -0.34 (36.5th percentile), this represents normal volume ; entorhinal cortex volume measures 2,815 mm³, 31.4% below the reference mean. With a Z-score of -2.13 (1.7th percentile), this represents significant atrophy; fusiform gyrus volume measures 14,919 mm³, 20.8% below the reference mean. With a Z-score of -1.77 (3.8th percentile), this represents moderate atrophy; middle temporal gyrus volume measures 19,137 mm³, 10.3% below the reference mean. With a Z-score of -0.93 (17.7th percentile), this represents normal volume . ",
  "text_data": "Age is 73.5 years. Gender is Male. Education: 16 years. MMSE: 21.0. MoCA: 19.0. Logical Memory: 12.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 414.70 pg/mL (moderate reduced); Total tau: 375.90 pg/mL (moderate elevated); Phosphorylated tau: 39.71 pg/mL (significant elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "Reasoning: The entorhinal cortex and fusiform gyrus show significant to moderate atrophy, which are early markers of Alzheimer's pathology. Combined with reduced Aβ, elevated T-tau and P-tau, and cognitive scores (MMSE 21, MoCA 19) below normal thresholds, this strongly suggests neurodegenerative disease. The APOE4 carrier status further supports Alzheimer's risk.  \nDiagnosis: Dementia (likely Alzheimer’s disease)  \nConfidence: High",
  "timestamp": "2025-07-26T02:13:03.823669"
}