{
  "ptid_time": "035_S_0341_2007-06-21",
  "img_path": "/data/qiuhui/data/adni/images/035_S_0341/2007-06-21/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 94,625 mm³, 145.7% above the reference mean. With a Z-score of 3.49 (100.0th percentile), this represents profound enlargement; hippocampal volume measures 5,572 mm³, 26.3% below the reference mean. With a Z-score of -2.56 (0.5th percentile), this represents significant atrophy; whole brain volume measures 1,024,800 mm³, 5.1% below the reference mean. With a Z-score of -0.66 (25.6th percentile), this represents normal volume ; entorhinal cortex volume measures 2,215 mm³, 46.0% below the reference mean. With a Z-score of -3.12 (0.1th percentile), this represents profound atrophy; fusiform gyrus volume measures 15,520 mm³, 17.6% below the reference mean. With a Z-score of -1.50 (6.7th percentile), this represents moderate atrophy; middle temporal gyrus volume measures 17,227 mm³, 19.3% below the reference mean. With a Z-score of -1.73 (4.2th percentile), this represents moderate atrophy. ",
  "text_data": "Age is 75.0 years. Gender is Male. Education: 16 years. MMSE: 25.0. Logical Memory: 0.0. APOEε4 alleles: 2.0. Biomarker levels: Amyloid beta: 505.30 pg/mL (mild reduced); Total tau: 219.40 pg/mL (normal ); Phosphorylated tau: 20.37 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows profound ventricular enlargement and significant atrophy in the hippocampus and entorhinal cortex, which are hallmark features of Alzheimer's disease (AD). The MMSE score of 25 is borderline, but the presence of two APOE4 alleles and mild Aβ reduction further support AD pathology.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T05:47:05.354447"
}