{
  "ptid_time": "133_S_0488_2006-06-02",
  "img_path": "/data/qiuhui/data/adni/images/133_S_0488/2006-06-02/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 14,768 mm³, 47.4% below the reference mean. With a Z-score of -1.09 (13.9th percentile), this represents mild atrophy; hippocampal volume measures 8,819 mm³, 24.0% above the reference mean. With a Z-score of 2.20 (98.6th percentile), this represents significant enlargement; whole brain volume measures 1,044,500 mm³, 7.2% above the reference mean. With a Z-score of 0.90 (81.7th percentile), this represents normal volume ; entorhinal cortex volume measures 4,167 mm³, 13.5% above the reference mean. With a Z-score of 0.83 (79.6th percentile), this represents normal volume ; fusiform gyrus volume measures 17,361 mm³, 2.0% above the reference mean. With a Z-score of 0.19 (57.4th percentile), this represents normal volume ; middle temporal gyrus volume measures 18,676 mm³, 2.6% below the reference mean. With a Z-score of -0.22 (41.2th percentile), this represents normal volume . ",
  "text_data": "Age is 70.9 years. Gender is Female. Education: 16 years. Handedness: Right. Race: White. Medical history: Psychiatric; Head, Eyes, Ears, Nose and Throat; Cardiovascular; Musculoskeletal; Endocrine-Metabolic; Gastrointestinal; Malignancy; Major Surgical Procedures. MMSE: 30.0. Logical Memory: 14.0. APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 873.80 pg/mL (normal ); Total tau: 186.60 pg/mL (normal ); Phosphorylated tau: 17.22 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: CN.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows mild ventricular atrophy but otherwise normal or above-average volumes in key regions (hippocampus, whole brain, entorhinal cortex). Biomarkers (Aβ, T-tau, P-tau) are normal, and cognitive performance (MMSE 30) is intact. The APOE4-negative status further reduces Alzheimer’s risk.  \n**Diagnosis:** CN (Cognitively Normal)  \n**Confidence:** High",
  "timestamp": "2025-07-26T15:16:41.722535"
}