{
  "ptid_time": "014_S_0658_2010-07-30",
  "img_path": "/data/qiuhui/data/adni/images/014_S_0658/2010-07-30/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 44,529 mm³, 15.6% above the reference mean. With a Z-score of 0.37 (64.6th percentile), this represents normal volume ; hippocampal volume measures 6,147 mm³, 18.7% below the reference mean. With a Z-score of -1.82 (3.4th percentile), this represents moderate atrophy; whole brain volume measures 1,008,750 mm³, 6.5% below the reference mean. With a Z-score of -0.85 (19.8th percentile), this represents normal volume ; entorhinal cortex volume measures 4,094 mm³, 0.2% below the reference mean. With a Z-score of -0.01 (49.6th percentile), this represents normal volume ; fusiform gyrus volume measures 19,499 mm³, 3.5% above the reference mean. With a Z-score of 0.30 (61.7th percentile), this represents normal volume ; middle temporal gyrus volume measures 19,148 mm³, 10.3% below the reference mean. With a Z-score of -0.92 (17.8th percentile), this represents normal volume . ",
  "text_data": "Age is 76.1 years. Gender is Male. Education: 18 years. Handedness: Right. Race: White. MMSE: 30.0. MoCA: 23.0. Logical Memory: 3.0. APOEε4 alleles: 0.0. Biomarker levels: Florbetapir (AV45): 1.70 SUVR (profound elevated); Amyloid beta: 563.50 pg/mL (mild reduced); Total tau: 399.80 pg/mL (significant elevated); Phosphorylated tau: 41.45 pg/mL (significant elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The hippocampal volume shows moderate atrophy (Z-score -1.82, 3.4th percentile), which is a strong biomarker for Alzheimer's pathology. Elevated T-tau, P-tau, and AV45 (amyloid PET) with mildly reduced Aβ further support Alzheimer's pathophysiology. Despite a normal MMSE (30), the MoCA (23) suggests subtle cognitive impairment.  \n**Diagnosis:** **Mild Cognitive Impairment (MCI) due to Alzheimer’s disease**  \n**Confidence:** **High**  \n\n*(Key findings: Hippocampal atrophy + abnormal CSF/PET biomarkers + MoCA <26, but preserved MMSE and no clear functional decline yet = MCI-AD.)*",
  "timestamp": "2025-07-25T23:46:58.264210"
}