{
  "ptid_time": "057_S_0474_2006-12-13",
  "img_path": "/data/qiuhui/data/adni/images/057_S_0474/2006-12-13/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 69,325 mm³, 147.0% above the reference mean. With a Z-score of 3.37 (100.0th percentile), this represents profound enlargement; hippocampal volume measures 5,388 mm³, 24.3% below the reference mean. With a Z-score of -2.23 (1.3th percentile), this represents significant atrophy; whole brain volume measures 914,094 mm³, 6.2% below the reference mean. With a Z-score of -0.78 (21.7th percentile), this represents normal volume ; entorhinal cortex volume measures 2,173 mm³, 40.8% below the reference mean. With a Z-score of -2.51 (0.6th percentile), this represents significant atrophy; fusiform gyrus volume measures 15,319 mm³, 10.0% below the reference mean. With a Z-score of -0.91 (18.2th percentile), this represents normal volume ; middle temporal gyrus volume measures 16,443 mm³, 14.2% below the reference mean. With a Z-score of -1.23 (10.8th percentile), this represents mild atrophy. ",
  "text_data": "Age is 77.8 years. Gender is Female. Education: 16 years. MMSE: 26.0. APOEε4 alleles: 2.0. ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound ventricular enlargement (147% above mean, Z=3.37) and significant atrophy in the hippocampus (Z=-2.23) and entorhinal cortex (Z=-2.51), which are hallmark biomarkers of Alzheimer's disease. The MMSE score of 26 is borderline but still within normal limits, though the structural changes suggest underlying pathology.  \n**Diagnosis:** Mild Cognitive Impairment (MCI) (likely prodromal Alzheimer's disease)  \n**Confidence:** High  \n\n*(Note: The presence of two APOE4 alleles further increases the likelihood of Alzheimer's pathology, but since the MMSE is not yet in the dementia range, MCI is the most fitting diagnosis.)*",
  "timestamp": "2025-07-26T08:03:30.029478"
}