{
  "ptid_time": "023_S_0084_2006-01-04",
  "img_path": "/data/qiuhui/data/adni/images/023_S_0084/2006-01-04/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 30,223 mm³, 7.7% above the reference mean. With a Z-score of 0.18 (57.0th percentile), this represents normal volume ; hippocampal volume measures 4,498 mm³, 36.8% below the reference mean. With a Z-score of -3.37 (0.0th percentile), this represents profound atrophy; whole brain volume measures 868,796 mm³, 10.9% below the reference mean. With a Z-score of -1.37 (8.6th percentile), this represents mild atrophy; entorhinal cortex volume measures 2,134 mm³, 41.9% below the reference mean. With a Z-score of -2.57 (0.5th percentile), this represents significant atrophy; fusiform gyrus volume measures 11,738 mm³, 31.0% below the reference mean. With a Z-score of -2.82 (0.2th percentile), this represents significant atrophy; middle temporal gyrus volume measures 16,842 mm³, 12.1% below the reference mean. With a Z-score of -1.05 (14.6th percentile), this represents mild atrophy. ",
  "text_data": "Age is 75.3 years. Gender is Female. Education: 14 years. MMSE: 24.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 479.60 pg/mL (mild reduced); Total tau: 283.20 pg/mL (normal ); Phosphorylated tau: 29.85 pg/mL (mild elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound hippocampal atrophy (Z-score -3.37) and significant atrophy in the entorhinal cortex (Z-score -2.57) and fusiform gyrus (Z-score -2.82), which are hallmark features of Alzheimer’s disease. The MMSE score of 24, along with mild Aβ reduction and mild P-tau elevation, further supports cognitive impairment consistent with dementia.  \n\n**Diagnosis:** Dementia (likely Alzheimer’s disease)  \n**Confidence:** High",
  "timestamp": "2025-07-26T02:35:11.725642"
}