{
  "ptid_time": "116_S_0392_2006-06-26",
  "img_path": "/data/qiuhui/data/adni/images/116_S_0392/2006-06-26/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 77,220 mm³, 108.9% above the reference mean. With a Z-score of 2.94 (99.8th percentile), this represents significant enlargement; hippocampal volume measures 4,322 mm³, 33.5% below the reference mean. With a Z-score of -2.68 (0.4th percentile), this represents significant atrophy; whole brain volume measures 880,787 mm³, 5.1% below the reference mean. With a Z-score of -0.61 (27.0th percentile), this represents normal volume ; entorhinal cortex volume measures 1,774 mm³, 48.8% below the reference mean. With a Z-score of -2.63 (0.4th percentile), this represents significant atrophy; fusiform gyrus volume measures 12,665 mm³, 21.4% below the reference mean. With a Z-score of -1.61 (5.4th percentile), this represents moderate atrophy; middle temporal gyrus volume measures 17,291 mm³, 4.1% below the reference mean. With a Z-score of -0.36 (35.8th percentile), this represents normal volume . ",
  "text_data": "Age is 84.6 years. Gender is Female. Education: 17 years. Handedness: Right. Race: White. Medical history: Head, Eyes, Ears, Nose and Throat; Dermatologic-Connective Tissue; Musculoskeletal; Gastrointestinal; Hematopoietic-Lymphatic; Smoking; Major Surgical Procedures. MMSE: 20.0. Logical Memory: 0.0. APOEε4 alleles: 2.0. ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows significant atrophy in the hippocampus and entorhinal cortex, both key regions affected in Alzheimer's disease (AD), along with moderate atrophy in the fusiform gyrus. Ventricular enlargement is also severe, consistent with neurodegeneration. The MMSE score of 20 indicates cognitive impairment, and the presence of two APOE4 alleles strongly increases AD risk.  \n\n**Diagnosis:** Dementia (likely Alzheimer’s disease)  \n**Confidence:** High",
  "timestamp": "2025-07-26T11:54:17.232020"
}