{
  "ptid_time": "003_S_0931_2006-10-11",
  "img_path": "/data/qiuhui/data/adni/images/003_S_0931/2006-10-11/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 18,667 mm³, 49.5% below the reference mean. With a Z-score of -1.34 (9.1th percentile), this represents mild atrophy; hippocampal volume measures 5,855 mm³, 9.9% below the reference mean. With a Z-score of -0.79 (21.5th percentile), this represents normal volume ; whole brain volume measures 817,085 mm³, 12.0% below the reference mean. With a Z-score of -1.44 (7.5th percentile), this represents mild atrophy; entorhinal cortex volume measures 3,279 mm³, 5.3% below the reference mean. With a Z-score of -0.29 (38.7th percentile), this represents normal volume ; fusiform gyrus volume measures 14,355 mm³, 10.9% below the reference mean. With a Z-score of -0.82 (20.6th percentile), this represents normal volume ; middle temporal gyrus volume measures 14,894 mm³, 17.4% below the reference mean. With a Z-score of -1.55 (6.1th percentile), this represents moderate atrophy. ",
  "text_data": "Age is 86.1 years. Gender is Female. Education: 14 years. Handedness: Right. Race: White. Medical history: Neurologic; Head, Eyes, Ears, Nose and Throat; Cardiovascular; Respiratory; Musculoskeletal; Endocrine-Metabolic; Gastrointestinal; Allergies or Drug Sensitivities; Major Surgical Procedures. MMSE: 28.0. Logical Memory: 18.0. APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 1435.00 pg/mL (mild elevated); Total tau: 247.50 pg/mL (normal ); Phosphorylated tau: 21.40 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: CN.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows mild to moderate atrophy in ventricular and whole brain volumes, as well as moderate atrophy in the middle temporal gyrus, but hippocampal and entorhinal volumes are within normal ranges. Clinically, the patient has a high MMSE score (28/30), no APOE4 alleles, and only mildly elevated Aβ with normal tau levels, suggesting minimal biomarker evidence of Alzheimer’s pathology.  \n\n**Diagnosis:** **CN (Cognitively Normal)**  \n**Confidence:** **Medium** (due to mild atrophy in some regions but strong cognitive performance and lack of significant biomarker abnormalities)",
  "timestamp": "2025-07-25T20:40:42.411388"
}