{
  "ptid_time": "067_S_0176_2007-05-22",
  "img_path": "/data/qiuhui/data/adni/images/067_S_0176/2007-05-22/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 38,379 mm³, 0.4% below the reference mean. With a Z-score of -0.01 (49.7th percentile), this represents normal volume ; hippocampal volume measures 5,661 mm³, 25.1% below the reference mean. With a Z-score of -2.45 (0.7th percentile), this represents significant atrophy; whole brain volume measures 1,006,420 mm³, 6.8% below the reference mean. With a Z-score of -0.88 (19.0th percentile), this represents normal volume ; entorhinal cortex volume measures 3,357 mm³, 18.1% below the reference mean. With a Z-score of -1.23 (10.9th percentile), this represents mild atrophy; fusiform gyrus volume measures 16,303 mm³, 13.5% below the reference mean. With a Z-score of -1.15 (12.6th percentile), this represents mild atrophy; middle temporal gyrus volume measures 19,571 mm³, 8.3% below the reference mean. With a Z-score of -0.74 (22.8th percentile), this represents normal volume . ",
  "text_data": "Age is 75.7 years. Gender is Male. Education: 19 years. MMSE: 27.0. Logical Memory: 2.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 699.60 pg/mL (normal ); Total tau: 417.80 pg/mL (significant elevated); Phosphorylated tau: 47.14 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The data shows significant hippocampal atrophy (Z-score -2.45, 0.7th percentile) and mild atrophy in the entorhinal cortex and fusiform gyrus, which are key regions affected in Alzheimer's disease. Elevated T-tau and P-tau levels with normal Aβ suggest tau pathology, consistent with AD, while the MMSE score of 27 is borderline but does not yet indicate severe cognitive impairment.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI)** (likely due to Alzheimer's pathology)  \n**Confidence:** **High** (due to clear biomarker and structural atrophy patterns despite near-normal MMSE)",
  "timestamp": "2025-07-26T08:26:23.051530"
}