{
  "ptid_time": "035_S_0204_2007-02-22",
  "img_path": "/data/qiuhui/data/adni/images/035_S_0204/2007-02-22/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 34,885 mm³, 24.3% above the reference mean. With a Z-score of 0.56 (71.1th percentile), this represents normal volume ; hippocampal volume measures 5,516 mm³, 22.5% below the reference mean. With a Z-score of -2.06 (2.0th percentile), this represents significant atrophy; whole brain volume measures 917,242 mm³, 5.9% below the reference mean. With a Z-score of -0.74 (22.9th percentile), this represents normal volume ; entorhinal cortex volume measures 3,332 mm³, 9.3% below the reference mean. With a Z-score of -0.57 (28.4th percentile), this represents normal volume ; fusiform gyrus volume measures 12,518 mm³, 26.4% below the reference mean. With a Z-score of -2.40 (0.8th percentile), this represents significant atrophy; middle temporal gyrus volume measures 15,784 mm³, 17.7% below the reference mean. With a Z-score of -1.53 (6.3th percentile), this represents moderate atrophy. ",
  "text_data": "Age is 72.1 years. Gender is Female. Education: 16 years. MMSE: 24.0. Logical Memory: 0.0. APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 273.90 pg/mL (moderate reduced); Total tau: 195.70 pg/mL (normal ); Phosphorylated tau: 20.66 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The patient shows significant atrophy in the hippocampus and fusiform gyrus, along with moderate atrophy in the middle temporal gyrus—key regions affected in Alzheimer’s disease (AD). The MMSE score of 24 suggests mild cognitive impairment, and moderate Aβ reduction supports AD pathology, though normal tau levels are atypical.  \n**Diagnosis:** **Mild Cognitive Impairment (MCI)** (likely due to Alzheimer’s pathology)  \n**Confidence:** **Medium** (atrophy pattern and Aβ support AD, but normal tau and lack of APOE4 reduce certainty).",
  "timestamp": "2025-07-26T05:44:49.187300"
}