{
  "ptid_time": "114_S_0166_2012-03-01",
  "img_path": "/data/qiuhui/data/adni/images/114_S_0166/2012-03-01/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 73,826 mm³, 163.0% above the reference mean. With a Z-score of 3.73 (100.0th percentile), this represents profound enlargement; whole brain volume measures 808,220 mm³, 17.1% below the reference mean. With a Z-score of -2.15 (1.6th percentile), this represents significant atrophy. ",
  "text_data": "Age is 78.5 years. Gender is Female. Education: 18 years. Handedness: Right. Race: White. Medical history: Neurologic; Head, Eyes, Ears, Nose and Throat; Cardiovascular; Musculoskeletal. MMSE: 26.0. MoCA: 20.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 551.90 pg/mL (mild reduced); Total tau: 249.50 pg/mL (normal ); Phosphorylated tau: 24.16 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound ventricular enlargement (163% above reference mean) and significant whole brain atrophy (17.1% below reference mean), consistent with neurodegenerative changes. The MMSE (26) is borderline normal, but the MoCA (20) suggests cognitive impairment, while CSF biomarkers (mildly reduced Aβ, normal tau) do not strongly support Alzheimer’s pathology.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI)**  \n**Confidence:** **Medium** (due to conflicting biomarker and imaging findings, but cognitive scores and structural changes suggest MCI rather than dementia or normal cognition).",
  "timestamp": "2025-07-26T11:37:29.417894"
}