{
  "ptid_time": "137_S_4672_2014-04-16",
  "img_path": "/data/qiuhui/data/adni/images/137_S_4672/2014-04-16/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 44,989 mm³, 49.8% above the reference mean. With a Z-score of 1.18 (88.2th percentile), this represents mild enlargement; hippocampal volume measures 5,403 mm³, 32.7% below the reference mean. With a Z-score of -3.27 (0.1th percentile), this represents profound atrophy; whole brain volume measures 970,951 mm³, 14.4% below the reference mean. With a Z-score of -2.04 (2.1th percentile), this represents significant atrophy; entorhinal cortex volume measures 2,584 mm³, 39.4% below the reference mean. With a Z-score of -2.73 (0.3th percentile), this represents significant atrophy; fusiform gyrus volume measures 12,627 mm³, 36.6% below the reference mean. With a Z-score of -3.04 (0.1th percentile), this represents profound atrophy; middle temporal gyrus volume measures 15,388 mm³, 31.3% below the reference mean. With a Z-score of -2.58 (0.5th percentile), this represents significant atrophy. ",
  "text_data": "Age is 68.8 years. Gender is Male. Education: 12 years. MMSE: 16.0. MoCA: 13.0. Logical Memory: 0.0. APOEε4 alleles: 2.0. Biomarker levels: Florbetapir (AV45): 1.73 SUVR (profound elevated); Amyloid beta: 497.00 pg/mL (mild reduced); Total tau: 367.20 pg/mL (moderate elevated); Phosphorylated tau: 36.27 pg/mL (moderate elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound hippocampal atrophy, significant whole brain atrophy, and severe atrophy in key AD-related regions (entorhinal cortex, fusiform gyrus, middle temporal gyrus). Combined with low MMSE/MoCA scores, APOE4 homozygosity, elevated tau, and profoundly elevated amyloid (AV45), this strongly supports Alzheimer’s pathology.  \n\n**Diagnosis:** **Dementia (Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T16:41:14.982671"
}