{
  "ptid_time": "011_S_0010_2005-11-07",
  "img_path": "/data/qiuhui/data/adni/images/011_S_0010/2005-11-07/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 26,820 mm³, 4.4% below the reference mean. With a Z-score of -0.10 (45.9th percentile), this represents normal volume ; hippocampal volume measures 5,485 mm³, 22.9% below the reference mean. With a Z-score of -2.10 (1.8th percentile), this represents significant atrophy; whole brain volume measures 1,033,540 mm³, 6.0% above the reference mean. With a Z-score of 0.76 (77.7th percentile), this represents normal volume ; entorhinal cortex volume measures 2,676 mm³, 27.1% below the reference mean. With a Z-score of -1.67 (4.8th percentile), this represents moderate atrophy; fusiform gyrus volume measures 16,761 mm³, 1.5% below the reference mean. With a Z-score of -0.13 (44.6th percentile), this represents normal volume ; middle temporal gyrus volume measures 19,741 mm³, 3.0% above the reference mean. With a Z-score of 0.26 (60.2th percentile), this represents normal volume . ",
  "text_data": "Age is 73.9 years. Gender is Female. Education: 12 years. Handedness: Right. Race: White. Medical history: Psychiatric; Neurologic; Respiratory; Musculoskeletal; Endocrine-Metabolic; Gastrointestinal; Renal-Genitourinary. MMSE: 24.0. Logical Memory: 2.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 357.40 pg/mL (moderate reduced); Total tau: 329.90 pg/mL (mild elevated); Phosphorylated tau: 31.26 pg/mL (mild elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The hippocampal volume shows significant atrophy (Z-score -2.10, 1.8th percentile), and the entorhinal cortex has moderate atrophy (Z-score -1.67, 4.8th percentile), both key regions in Alzheimer's pathology. The MMSE score of 24 suggests mild cognitive impairment, and the biomarker profile (moderately reduced Aβ, mildly elevated T-tau and P-tau) supports an Alzheimer's-like neurodegenerative process.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI)** (likely due to Alzheimer’s pathology)  \n**Confidence:** **High** (due to clear structural and biomarker evidence of neurodegeneration, but not yet meeting full dementia criteria)",
  "timestamp": "2025-07-25T22:38:01.175291"
}