{
  "ptid_time": "126_S_0606_2006-07-20",
  "img_path": "/data/qiuhui/data/adni/images/126_S_0606/2006-07-20/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 29,603 mm³, 32.5% above the reference mean. With a Z-score of 0.81 (79.2th percentile), this represents normal volume ; hippocampal volume measures 5,106 mm³, 33.6% below the reference mean. With a Z-score of -3.77 (0.0th percentile), this represents profound atrophy; whole brain volume measures 958,683 mm³, 6.8% below the reference mean. With a Z-score of -0.85 (19.7th percentile), this represents normal volume ; entorhinal cortex volume measures 1,893 mm³, 51.4% below the reference mean. With a Z-score of -3.98 (0.0th percentile), this represents profound atrophy; fusiform gyrus volume measures 12,455 mm³, 31.6% below the reference mean. With a Z-score of -3.56 (0.0th percentile), this represents profound atrophy; middle temporal gyrus volume measures 16,694 mm³, 18.6% below the reference mean. With a Z-score of -1.66 (4.9th percentile), this represents moderate atrophy. ",
  "text_data": "Age is 68.5 years. Gender is Female. Education: 10 years. Handedness: Right. Race: White. Medical history: Head, Eyes, Ears, Nose and Throat; Cardiovascular; Musculoskeletal; Endocrine-Metabolic; Gastrointestinal; Major Surgical Procedures. MMSE: 23.0. Logical Memory: 0.0. APOEε4 alleles: 2.0. Biomarker levels: Amyloid beta: 336.80 pg/mL (moderate reduced); Total tau: 294.00 pg/mL (normal ); Phosphorylated tau: 33.57 pg/mL (moderate elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "Reasoning: The patient exhibits profound atrophy in the hippocampus, entorhinal cortex, and fusiform gyrus, along with moderate atrophy in the middle temporal gyrus—key regions affected in Alzheimer's disease. Combined with reduced Aβ, elevated P-tau, and an MMSE score of 23 (indicating cognitive impairment), this strongly suggests neurodegenerative pathology.  \nDiagnosis: Dementia (likely Alzheimer's disease)  \nConfidence: High",
  "timestamp": "2025-07-26T12:36:37.453554"
}