{
  "ptid_time": "033_S_0733_2006-08-18",
  "img_path": "/data/qiuhui/data/adni/images/033_S_0733/2006-08-18/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 14,395 mm³, 22.7% below the reference mean. With a Z-score of -0.65 (25.8th percentile), this represents normal volume ; hippocampal volume measures 6,699 mm³, 14.2% below the reference mean. With a Z-score of -1.98 (2.4th percentile), this represents moderate atrophy; whole brain volume measures 888,699 mm³, 14.6% below the reference mean. With a Z-score of -1.75 (4.0th percentile), this represents moderate atrophy; entorhinal cortex volume measures 3,748 mm³, 1.4% above the reference mean. With a Z-score of 0.11 (54.4th percentile), this represents normal volume ; fusiform gyrus volume measures 18,949 mm³, 2.8% above the reference mean. With a Z-score of 0.25 (60.1th percentile), this represents normal volume ; middle temporal gyrus volume measures 14,805 mm³, 27.9% below the reference mean. With a Z-score of -2.30 (1.1th percentile), this represents significant atrophy. ",
  "text_data": "Age is 57.1 years. Gender is Female. Education: 14 years. Handedness: Right. Race: White. Medical history: Head, Eyes, Ears, Nose and Throat; Cardiovascular; Musculoskeletal. MMSE: 23.0. Logical Memory: 2.0. APOEε4 alleles: 2.0. Biomarker levels: Amyloid beta: 711.90 pg/mL (normal ); Total tau: 456.80 pg/mL (significant elevated); Phosphorylated tau: 45.20 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "Reasoning: The patient exhibits significant hippocampal and whole brain atrophy, along with profound atrophy in the middle temporal gyrus, which are hallmark structural changes in Alzheimer's disease (AD). Elevated T-tau and P-tau levels with normal Aβ suggest a tauopathy consistent with AD, while the MMSE score of 23 indicates cognitive impairment.  \nDiagnosis: Dementia (likely Alzheimer’s disease)  \nConfidence: High",
  "timestamp": "2025-07-26T05:16:12.985129"
}