{
  "ptid_time": "094_S_1102_2006-11-24",
  "img_path": "/data/qiuhui/data/adni/images/094_S_1102/2006-11-24/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 78,281 mm³, 178.9% above the reference mean. With a Z-score of 4.10 (100.0th percentile), this represents profound enlargement; hippocampal volume measures 4,732 mm³, 33.5% below the reference mean. With a Z-score of -3.07 (0.1th percentile), this represents profound atrophy; whole brain volume measures 727,478 mm³, 25.4% below the reference mean. With a Z-score of -3.19 (0.1th percentile), this represents profound atrophy; entorhinal cortex volume measures 2,553 mm³, 30.5% below the reference mean. With a Z-score of -1.87 (3.1th percentile), this represents moderate atrophy; fusiform gyrus volume measures 12,635 mm³, 25.7% below the reference mean. With a Z-score of -2.34 (1.0th percentile), this represents significant atrophy; middle temporal gyrus volume measures 16,137 mm³, 15.8% below the reference mean. With a Z-score of -1.37 (8.5th percentile), this represents mild atrophy. ",
  "text_data": "Age is 72.8 years. Gender is Female. Education: 16 years. Handedness: Right. Race: White. Medical history: Cardiovascular; Respiratory; Dermatologic-Connective Tissue; Musculoskeletal; Allergies or Drug Sensitivities; Smoking. MMSE: 26.0. Logical Memory: 1.0. APOEε4 alleles: 2.0. ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows profound atrophy in the hippocampus and whole brain volume, along with significant ventricular enlargement, which are hallmark features of Alzheimer's disease. The MMSE score of 26 is borderline but still within normal limits, suggesting possible early cognitive impairment. The presence of two APOE4 alleles further increases the risk for Alzheimer's pathology.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI)**, likely due to Alzheimer's disease.  \n\n**Confidence:** **High** (given the strong imaging biomarkers and genetic risk, despite the near-normal MMSE).",
  "timestamp": "2025-07-26T10:15:39.727577"
}