{
  "ptid_time": "035_S_0341_2006-04-06",
  "img_path": "/data/qiuhui/data/adni/images/035_S_0341/2006-04-06/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 86,769 mm³, 125.3% above the reference mean. With a Z-score of 3.00 (99.9th percentile), this represents profound enlargement; hippocampal volume measures 5,890 mm³, 22.1% below the reference mean. With a Z-score of -2.15 (1.6th percentile), this represents significant atrophy; whole brain volume measures 1,044,930 mm³, 3.2% below the reference mean. With a Z-score of -0.41 (33.9th percentile), this represents normal volume ; entorhinal cortex volume measures 1,965 mm³, 52.1% below the reference mean. With a Z-score of -3.53 (0.0th percentile), this represents profound atrophy; fusiform gyrus volume measures 15,218 mm³, 19.2% below the reference mean. With a Z-score of -1.64 (5.1th percentile), this represents moderate atrophy; middle temporal gyrus volume measures 18,886 mm³, 11.5% below the reference mean. With a Z-score of -1.03 (15.1th percentile), this represents mild atrophy. ",
  "text_data": "Age is 74.0 years. Gender is Male. Education: 16 years. Handedness: Right. Race: White. Medical history: Cardiovascular; Dermatologic-Connective Tissue; Musculoskeletal; Endocrine-Metabolic; Renal-Genitourinary; Malignancy; Major Surgical Procedures. MMSE: 25.0. Logical Memory: 0.0. APOEε4 alleles: 2.0. Biomarker levels: Amyloid beta: 313.10 pg/mL (moderate reduced); Total tau: 197.80 pg/mL (normal ); Phosphorylated tau: 19.33 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound ventricular enlargement and significant atrophy in the hippocampus and entorhinal cortex, which are hallmark features of Alzheimer's disease (AD). The MMSE score of 25 suggests mild cognitive impairment, and the presence of two APOE4 alleles along with moderately reduced Aβ supports an AD pathology.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T05:46:46.597428"
}