{
  "ptid_time": "027_S_1081_2009-02-02",
  "img_path": "/data/qiuhui/data/adni/images/027_S_1081/2009-02-02/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 86,157 mm³, 83.2% above the reference mean. With a Z-score of 2.42 (99.2th percentile), this represents significant enlargement; hippocampal volume measures 5,054 mm³, 27.5% below the reference mean. With a Z-score of -2.37 (0.9th percentile), this represents significant atrophy; whole brain volume measures 927,010 mm³, 9.9% below the reference mean. With a Z-score of -1.30 (9.7th percentile), this represents mild atrophy; entorhinal cortex volume measures 1,838 mm³, 53.7% below the reference mean. With a Z-score of -3.51 (0.0th percentile), this represents profound atrophy; fusiform gyrus volume measures 12,592 mm³, 30.3% below the reference mean. With a Z-score of -2.62 (0.4th percentile), this represents significant atrophy; middle temporal gyrus volume measures 16,921 mm³, 16.1% below the reference mean. With a Z-score of -1.44 (7.4th percentile), this represents mild atrophy. ",
  "text_data": "Age is 86.5 years. Gender is Male. Education: 20 years. MMSE: 22.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 553.50 pg/mL (mild reduced); Total tau: 378.20 pg/mL (moderate elevated); Phosphorylated tau: 36.12 pg/mL (moderate elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows significant atrophy in key Alzheimer's-related regions (hippocampus, entorhinal cortex, fusiform gyrus) alongside ventricular enlargement, consistent with neurodegeneration. The clinical profile (reduced MMSE, APOE4 carrier, abnormal CSF biomarkers) further supports Alzheimer's pathology.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T03:46:22.455380"
}