{
  "ptid_time": "027_S_1082_2006-12-13",
  "img_path": "/data/qiuhui/data/adni/images/027_S_1082/2006-12-13/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 45,989 mm³, 105.9% above the reference mean. With a Z-score of 2.65 (99.6th percentile), this represents significant enlargement; hippocampal volume measures 4,682 mm³, 39.1% below the reference mean. With a Z-score of -4.38 (0.0th percentile), this represents profound atrophy; whole brain volume measures 870,569 mm³, 15.4% below the reference mean. With a Z-score of -1.92 (2.8th percentile), this represents moderate atrophy; entorhinal cortex volume measures 2,226 mm³, 42.8% below the reference mean. With a Z-score of -3.32 (0.0th percentile), this represents profound atrophy; fusiform gyrus volume measures 12,121 mm³, 33.4% below the reference mean. With a Z-score of -3.77 (0.0th percentile), this represents profound atrophy; middle temporal gyrus volume measures 14,799 mm³, 27.9% below the reference mean. With a Z-score of -2.48 (0.7th percentile), this represents significant atrophy. ",
  "text_data": "Age is 69.5 years. Gender is Female. Education: 13 years. Handedness: Right. Race: White. Medical history: Neurologic; Head, Eyes, Ears, Nose and Throat; Endocrine-Metabolic; Allergies or Drug Sensitivities; Smoking; Major Surgical Procedures. MMSE: 22.0. Logical Memory: 0.0. APOEε4 alleles: 2.0. Biomarker levels: Amyloid beta: 517.60 pg/mL (mild reduced); Total tau: 357.70 pg/mL (mild elevated); Phosphorylated tau: 32.96 pg/mL (mild elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows profound atrophy in key Alzheimer's-related regions (hippocampus, entorhinal cortex, fusiform gyrus) alongside significant ventricular enlargement, consistent with advanced neurodegeneration. The clinical profile (MMSE 22, APOE4 homozygous, and mildly abnormal CSF biomarkers) further supports Alzheimer's pathology.  \n\n**Diagnosis:** **Dementia** (likely Alzheimer's disease)  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T03:46:41.691534"
}