{
  "ptid_time": "067_S_1253_2007-03-30",
  "img_path": "/data/qiuhui/data/adni/images/067_S_1253/2007-03-30/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 32,915 mm³, 47.4% above the reference mean. With a Z-score of 1.19 (88.2th percentile), this represents mild enlargement; hippocampal volume measures 7,797 mm³, 1.5% above the reference mean. With a Z-score of 0.16 (56.5th percentile), this represents normal volume ; whole brain volume measures 936,013 mm³, 9.1% below the reference mean. With a Z-score of -1.13 (13.0th percentile), this represents mild atrophy; entorhinal cortex volume measures 3,741 mm³, 3.9% below the reference mean. With a Z-score of -0.30 (38.1th percentile), this represents normal volume ; fusiform gyrus volume measures 13,491 mm³, 25.9% below the reference mean. With a Z-score of -2.92 (0.2th percentile), this represents significant atrophy; middle temporal gyrus volume measures 16,195 mm³, 21.1% below the reference mean. With a Z-score of -1.87 (3.1th percentile), this represents moderate atrophy. ",
  "text_data": "Age is 62.6 years. Gender is Female. Education: 14 years. Handedness: Right. Race: White. Medical history: Psychiatric; Respiratory; Endocrine-Metabolic; Smoking. MMSE: 24.0. Logical Memory: 4.0. APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 552.50 pg/mL (mild reduced); Total tau: 314.50 pg/mL (normal ); Phosphorylated tau: 34.83 pg/mL (moderate elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows significant atrophy in the fusiform gyrus and moderate atrophy in the middle temporal gyrus, along with mild whole-brain atrophy. The MMSE score of 24 suggests mild cognitive impairment, and the presence of moderately elevated P-tau with mildly reduced Aβ supports underlying Alzheimer’s pathology. However, hippocampal and entorhinal cortex volumes are normal, which may argue against advanced dementia.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI)** (likely due to Alzheimer’s pathology)  \n**Confidence:** **Medium** (due to mixed findings—some regions show significant atrophy while others are preserved, and biomarker profile is suggestive but not definitive)",
  "timestamp": "2025-07-26T08:32:25.775486"
}