{
  "ptid_time": "123_S_0106_2007-01-24",
  "img_path": "/data/qiuhui/data/adni/images/123_S_0106/2007-01-24/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 47,081 mm³, 67.7% above the reference mean. With a Z-score of 1.55 (94.0th percentile), this represents moderate enlargement; hippocampal volume measures 7,544 mm³, 6.0% above the reference mean. With a Z-score of 0.55 (71.0th percentile), this represents normal volume ; whole brain volume measures 1,136,560 mm³, 16.6% above the reference mean. With a Z-score of 2.09 (98.2th percentile), this represents significant enlargement; entorhinal cortex volume measures 4,896 mm³, 33.3% above the reference mean. With a Z-score of 2.04 (98.0th percentile), this represents significant enlargement; fusiform gyrus volume measures 16,757 mm³, 1.5% below the reference mean. With a Z-score of -0.14 (44.6th percentile), this represents normal volume ; middle temporal gyrus volume measures 20,961 mm³, 9.3% above the reference mean. With a Z-score of 0.81 (79.1th percentile), this represents normal volume . ",
  "text_data": "Age is 74.2 years. Gender is Female. Education: 15 years. MMSE: 29.0. Logical Memory: 17.0. APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 611.80 pg/mL (mild reduced); Total tau: 215.90 pg/mL (normal ); Phosphorylated tau: 18.87 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: CN.",
  "gpt_diagnosis": "**Reasoning:** The patient shows moderate ventricular enlargement (suggestive of some atrophy) but otherwise has normal to above-normal hippocampal, whole brain, entorhinal cortex, and temporal lobe volumes. Cognitive testing (MMSE 29/30) is intact, and CSF biomarkers (Aβ mildly reduced, normal tau) do not strongly support Alzheimer’s pathology. APOE4-negative status further reduces AD risk.  \n\n**Diagnosis:** **Cognitively Normal (CN)**  \n**Confidence:** **Medium** (Ventricular enlargement raises some concern, but other structural and clinical findings are reassuring.)",
  "timestamp": "2025-07-26T12:23:30.320196"
}