{
  "ptid_time": "133_S_1170_2008-01-29",
  "img_path": "/data/qiuhui/data/adni/images/133_S_1170/2008-01-29/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 42,910 mm³, 11.4% above the reference mean. With a Z-score of 0.27 (60.8th percentile), this represents normal volume ; hippocampal volume measures 5,054 mm³, 33.1% below the reference mean. With a Z-score of -3.23 (0.1th percentile), this represents profound atrophy; whole brain volume measures 917,924 mm³, 15.0% below the reference mean. With a Z-score of -1.94 (2.6th percentile), this represents moderate atrophy; entorhinal cortex volume measures 2,784 mm³, 32.1% below the reference mean. With a Z-score of -2.18 (1.5th percentile), this represents significant atrophy; fusiform gyrus volume measures 16,553 mm³, 12.1% below the reference mean. With a Z-score of -1.03 (15.1th percentile), this represents mild atrophy; middle temporal gyrus volume measures 15,605 mm³, 26.9% below the reference mean. With a Z-score of -2.42 (0.8th percentile), this represents significant atrophy. ",
  "text_data": "Age is 73.9 years. Gender is Male. Education: 13 years. MMSE: 24.0. Logical Memory: 3.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 636.50 pg/mL (mild reduced); Total tau: 529.50 pg/mL (profound elevated); Phosphorylated tau: 55.68 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound hippocampal atrophy (Z-score -3.23), significant entorhinal and middle temporal gyrus atrophy, and moderate whole-brain atrophy, alongside elevated tau biomarkers (T-tau and P-tau) and mildly reduced Aβ—consistent with Alzheimer’s pathology. The MMSE score of 24 suggests cognitive impairment but not severe dementia.  \n**Diagnosis:** **Mild Cognitive Impairment (MCI) due to Alzheimer’s disease**  \n**Confidence:** **High**  \n\n*(Rationale: Structural atrophy in AD-vulnerable regions + biomarker profile strongly supports MCI-AD, while MMSE rules out advanced dementia.)*",
  "timestamp": "2025-07-26T15:32:18.119575"
}