{
  "ptid_time": "022_S_0543_2007-09-26",
  "img_path": "/data/qiuhui/data/adni/images/022_S_0543/2007-09-26/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 30,726 mm³, 9.5% above the reference mean. With a Z-score of 0.22 (58.6th percentile), this represents normal volume ; hippocampal volume measures 4,895 mm³, 31.2% below the reference mean. With a Z-score of -2.86 (0.2th percentile), this represents significant atrophy; whole brain volume measures 702,018 mm³, 28.0% below the reference mean. With a Z-score of -3.52 (0.0th percentile), this represents profound atrophy; entorhinal cortex volume measures 3,190 mm³, 13.1% below the reference mean. With a Z-score of -0.81 (21.0th percentile), this represents normal volume ; fusiform gyrus volume measures 10,826 mm³, 36.4% below the reference mean. With a Z-score of -3.31 (0.0th percentile), this represents profound atrophy; middle temporal gyrus volume measures 11,345 mm³, 40.8% below the reference mean. With a Z-score of -3.54 (0.0th percentile), this represents profound atrophy. ",
  "text_data": "Age is 73.2 years. Gender is Female. Education: 18 years. MMSE: 14.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 479.60 pg/mL (mild reduced); Total tau: 486.50 pg/mL (profound elevated); Phosphorylated tau: 49.32 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound atrophy in the hippocampus, whole brain, fusiform gyrus, and middle temporal gyrus—key regions affected in Alzheimer’s disease. Combined with a low MMSE score (14/30), elevated tau biomarkers, and APOE4 positivity, this strongly suggests neurodegenerative pathology consistent with Alzheimer’s dementia.  \n\n**Diagnosis:** Dementia (likely Alzheimer’s disease)  \n**Confidence:** High",
  "timestamp": "2025-07-26T02:05:30.677061"
}