{
  "ptid_time": "068_S_1075_2006-12-14",
  "img_path": "/data/qiuhui/data/adni/images/068_S_1075/2006-12-14/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 50,022 mm³, 66.6% above the reference mean. With a Z-score of 1.58 (94.3th percentile), this represents moderate enlargement; hippocampal volume measures 8,581 mm³, 6.9% above the reference mean. With a Z-score of 0.69 (75.5th percentile), this represents normal volume ; whole brain volume measures 1,245,850 mm³, 9.8% above the reference mean. With a Z-score of 1.39 (91.8th percentile), this represents mild enlargement; entorhinal cortex volume measures 4,934 mm³, 15.7% above the reference mean. With a Z-score of 1.09 (86.2th percentile), this represents mild enlargement; fusiform gyrus volume measures 22,690 mm³, 14.0% above the reference mean. With a Z-score of 1.16 (87.7th percentile), this represents mild enlargement; middle temporal gyrus volume measures 24,693 mm³, 10.2% above the reference mean. With a Z-score of 0.84 (79.9th percentile), this represents normal volume . ",
  "text_data": "Age is 67.1 years. Gender is Male. Education: 18 years. Handedness: Right. Race: White. Medical history: Neurologic; Cardiovascular; Dermatologic-Connective Tissue; Musculoskeletal; Renal-Genitourinary; Malignancy; Major Surgical Procedures. MMSE: 25.0. Logical Memory: 6.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 670.50 pg/mL (normal ); Total tau: 100.90 pg/mL (moderate reduced); Phosphorylated tau: 9.35 pg/mL (moderate reduced). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The ventricular volume is moderately enlarged (66.6% above reference mean, Z-score 1.58), which can indicate atrophy, but hippocampal volume is normal (Z-score 0.69). Whole brain and other cortical volumes are mildly enlarged or normal. MMSE is borderline (25/30), but Aβ is normal, and both T-tau and P-tau are moderately reduced, which is atypical for Alzheimer’s pathology.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI)**  \n**Confidence:** **Medium** (due to conflicting biomarkers—normal Aβ but reduced tau, along with borderline MMSE and ventricular enlargement suggesting possible early neurodegeneration).",
  "timestamp": "2025-07-26T08:52:11.060842"
}