{
  "ptid_time": "007_S_0293_2007-04-16",
  "img_path": "/data/qiuhui/data/adni/images/007_S_0293/2007-04-16/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 47,033 mm³, 0.0% above the reference mean. With a Z-score of 0.00 (50.0th percentile), this represents normal volume ; hippocampal volume measures 6,876 mm³, 1.3% below the reference mean. With a Z-score of -0.11 (45.5th percentile), this represents normal volume ; whole brain volume measures 1,118,680 mm³, 8.7% above the reference mean. With a Z-score of 1.14 (87.3th percentile), this represents mild enlargement; entorhinal cortex volume measures 4,047 mm³, 2.0% above the reference mean. With a Z-score of 0.13 (55.1th percentile), this represents normal volume ; fusiform gyrus volume measures 17,699 mm³, 2.0% below the reference mean. With a Z-score of -0.18 (43.0th percentile), this represents normal volume ; middle temporal gyrus volume measures 18,035 mm³, 10.6% below the reference mean. With a Z-score of -0.95 (17.1th percentile), this represents normal volume . ",
  "text_data": "Age is 88.7 years. Gender is Male. Education: 12 years. MMSE: 25.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 618.10 pg/mL (mild reduced); Total tau: 526.20 pg/mL (profound elevated); Phosphorylated tau: 48.41 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The brain volume measurements are largely within normal ranges, with only mild deviations (e.g., slightly reduced hippocampal volume and moderately reduced middle temporal gyrus volume). However, the biomarker profile (mildly reduced Aβ, profoundly elevated T-tau and P-tau) strongly suggests Alzheimer’s pathology. The MMSE score of 25 is borderline but still within the normal range for age.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI) due to Alzheimer’s disease**  \n**Confidence:** **High** (due to strong biomarker evidence despite relatively preserved cognitive scores and brain volumes)",
  "timestamp": "2025-07-25T21:48:40.332878"
}