{
  "ptid_time": "123_S_4526_2012-02-09",
  "img_path": "/data/qiuhui/data/adni/images/123_S_4526/2012-02-09/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 55,032 mm³, 42.9% above the reference mean. With a Z-score of 1.03 (84.8th percentile), this represents mild enlargement; hippocampal volume measures 4,977 mm³, 34.2% below the reference mean. With a Z-score of -3.33 (0.0th percentile), this represents profound atrophy; whole brain volume measures 958,399 mm³, 11.2% below the reference mean. With a Z-score of -1.46 (7.3th percentile), this represents mild atrophy; entorhinal cortex volume measures 2,883 mm³, 29.7% below the reference mean. With a Z-score of -2.01 (2.2th percentile), this represents significant atrophy; fusiform gyrus volume measures 16,071 mm³, 14.7% below the reference mean. With a Z-score of -1.25 (10.5th percentile), this represents mild atrophy; middle temporal gyrus volume measures 18,466 mm³, 13.5% below the reference mean. With a Z-score of -1.21 (11.3th percentile), this represents mild atrophy. ",
  "text_data": "Age is 79.4 years. Gender is Male. Education: 16 years. Handedness: Right. Race: White. Medical history: Psychiatric; Head, Eyes, Ears, Nose and Throat; Cardiovascular; Musculoskeletal; Major Surgical Procedures. MMSE: 22.0. MoCA: 19.0. Logical Memory: 0.0. APOEε4 alleles: 2.0. Biomarker levels: Florbetapir (AV45): 1.50 SUVR (profound elevated); Amyloid beta: 366.00 pg/mL (moderate reduced); Total tau: 466.60 pg/mL (significant elevated); Phosphorylated tau: 49.71 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound hippocampal atrophy (Z-score -3.33) and significant entorhinal cortex atrophy (Z-score -2.01), both strongly associated with Alzheimer's pathology. Elevated biomarkers (Aβ reduction, elevated T-tau, P-tau, and AV45) confirm amyloid deposition and neurodegeneration. Cognitive scores (MMSE 22, MoCA 19) indicate moderate impairment.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T12:32:50.586590"
}