{
  "ptid_time": "052_S_0671_2011-06-27",
  "img_path": "/data/qiuhui/data/adni/images/052_S_0671/2011-06-27/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 24,363 mm³, 9.1% above the reference mean. With a Z-score of 0.23 (59.0th percentile), this represents normal volume ; hippocampal volume measures 4,973 mm³, 35.3% below the reference mean. With a Z-score of -3.96 (0.0th percentile), this represents profound atrophy; whole brain volume measures 863,463 mm³, 16.1% below the reference mean. With a Z-score of -2.00 (2.3th percentile), this represents significant atrophy; entorhinal cortex volume measures 1,736 mm³, 55.4% below the reference mean. With a Z-score of -4.29 (0.0th percentile), this represents profound atrophy; fusiform gyrus volume measures 13,459 mm³, 26.1% below the reference mean. With a Z-score of -2.94 (0.2th percentile), this represents significant atrophy; middle temporal gyrus volume measures 14,432 mm³, 29.7% below the reference mean. With a Z-score of -2.64 (0.4th percentile), this represents significant atrophy. ",
  "text_data": "Age is 66.0 years. Gender is Female. Education: 12 years. Handedness: Right. Race: White. Medical history: Head, Eyes, Ears, Nose and Throat; Cardiovascular; Dermatologic-Connective Tissue; Musculoskeletal; Renal-Genitourinary; Allergies or Drug Sensitivities. MMSE: 21.0. MoCA: 18.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Florbetapir (AV45): 1.32 SUVR (moderate elevated); Amyloid beta: 556.30 pg/mL (mild reduced); Total tau: 392.50 pg/mL (moderate elevated); Phosphorylated tau: 39.31 pg/mL (significant elevated). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "Reasoning: The imaging data shows profound atrophy in the hippocampus and entorhinal cortex, along with significant atrophy in the whole brain, fusiform gyrus, and middle temporal gyrus—all regions heavily implicated in Alzheimer's disease. The clinical biomarkers (elevated P-tau, T-tau, and AV45, along with reduced Aβ) strongly support an Alzheimer's pathology, and the cognitive scores (MMSE 21, MoCA 18) indicate significant impairment.  \n\nDiagnosis: **Dementia (likely Alzheimer’s disease)**  \nConfidence: **High**",
  "timestamp": "2025-07-26T07:40:01.062715"
}