{
  "ptid_time": "136_S_0195_2006-03-13",
  "img_path": "/data/qiuhui/data/adni/images/136_S_0195/2006-03-13/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 99,907 mm³, 159.4% above the reference mean. With a Z-score of 3.82 (100.0th percentile), this represents profound enlargement; hippocampal volume measures 5,875 mm³, 22.3% below the reference mean. With a Z-score of -2.17 (1.5th percentile), this represents significant atrophy; whole brain volume measures 908,543 mm³, 15.8% below the reference mean. With a Z-score of -2.05 (2.0th percentile), this represents significant atrophy; entorhinal cortex volume measures 3,166 mm³, 22.8% below the reference mean. With a Z-score of -1.55 (6.1th percentile), this represents moderate atrophy; fusiform gyrus volume measures 11,645 mm³, 38.2% below the reference mean. With a Z-score of -3.25 (0.1th percentile), this represents profound atrophy; middle temporal gyrus volume measures 19,068 mm³, 10.6% below the reference mean. With a Z-score of -0.96 (16.9th percentile), this represents normal volume . ",
  "text_data": "Age is 79.6 years. Gender is Male. Education: 18 years. Handedness: Right. Race: White. Medical history: Head, Eyes, Ears, Nose and Throat; Cardiovascular; Endocrine-Metabolic; Allergies or Drug Sensitivities; Smoking. MMSE: 25.0. Logical Memory: 5.0. APOEε4 alleles: 1.0. ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound ventricular enlargement and significant atrophy in the hippocampus, whole brain, entorhinal cortex, and fusiform gyrus, which are hallmark structural changes in Alzheimer's disease. The MMSE score of 25 is borderline but aligns with mild cognitive impairment (MCI) or early dementia, particularly given the severe atrophy in key regions. The presence of one APOE4 allele further increases Alzheimer's risk.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T15:58:56.913198"
}