{
  "ptid_time": "007_S_5265_2015-08-25",
  "img_path": "/data/qiuhui/data/adni/images/007_S_5265/2015-08-25/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 64,212 mm³, 128.8% above the reference mean. With a Z-score of 2.95 (99.8th percentile), this represents significant enlargement; hippocampal volume measures 7,170 mm³, 0.8% above the reference mean. With a Z-score of 0.07 (52.9th percentile), this represents normal volume ; whole brain volume measures 981,307 mm³, 0.7% above the reference mean. With a Z-score of 0.09 (53.4th percentile), this represents normal volume ; entorhinal cortex volume measures 3,549 mm³, 3.4% below the reference mean. With a Z-score of -0.21 (41.8th percentile), this represents normal volume ; fusiform gyrus volume measures 17,583 mm³, 3.3% above the reference mean. With a Z-score of 0.30 (62.0th percentile), this represents normal volume ; middle temporal gyrus volume measures 21,640 mm³, 12.9% above the reference mean. With a Z-score of 1.12 (86.8th percentile), this represents mild enlargement. ",
  "text_data": "Age is 77.1 years. Gender is Female. Education: 18 years. MMSE: 28.0. MoCA: 25.0. Logical Memory: 13.0. APOEε4 alleles: 0.0. Biomarker levels: Florbetapir (AV45): 1.57 SUVR (profound elevated); Amyloid beta: 376.80 pg/mL (moderate reduced); Total tau: 266.50 pg/mL (normal ); Phosphorylated tau: 27.36 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: CN.",
  "gpt_diagnosis": "Reasoning: The data shows significant ventricular enlargement (Z-score 2.95) and moderate Aβ reduction with profound AV45 elevation, suggesting amyloid pathology. However, hippocampal and whole brain volumes are normal, and cognitive scores (MMSE 28, MoCA 25) are near-normal, indicating preserved cognitive function despite biomarker abnormalities.  \nDiagnosis: **MCI** (mild cognitive impairment, likely amyloid-positive but without significant neurodegeneration or functional decline)  \nConfidence: **Medium** (cognitive scores are borderline, and neurodegeneration markers are not strongly elevated, but amyloid burden is significant)",
  "timestamp": "2025-07-25T22:07:21.179447"
}