{
  "ptid_time": "023_S_0376_2006-04-28",
  "img_path": "/data/qiuhui/data/adni/images/023_S_0376/2006-04-28/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 61,934 mm³, 60.8% above the reference mean. With a Z-score of 1.46 (92.7th percentile), this represents mild enlargement; hippocampal volume measures 7,036 mm³, 6.9% below the reference mean. With a Z-score of -0.68 (25.0th percentile), this represents normal volume ; whole brain volume measures 993,712 mm³, 7.9% below the reference mean. With a Z-score of -1.03 (15.1th percentile), this represents mild atrophy; entorhinal cortex volume measures 4,061 mm³, 1.0% below the reference mean. With a Z-score of -0.07 (47.4th percentile), this represents normal volume ; fusiform gyrus volume measures 17,368 mm³, 7.8% below the reference mean. With a Z-score of -0.66 (25.3th percentile), this represents normal volume ; middle temporal gyrus volume measures 19,173 mm³, 10.2% below the reference mean. With a Z-score of -0.91 (18.1th percentile), this represents normal volume . ",
  "text_data": "Age is 70.5 years. Gender is Male. Education: 15 years. Handedness: Right. Race: White. Medical history: Head, Eyes, Ears, Nose and Throat; Hepatic; Dermatologic-Connective Tissue; Musculoskeletal; Renal-Genitourinary; Major Surgical Procedures. MMSE: 28.0. Logical Memory: 3.0. APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 1148.00 pg/mL (normal ); Total tau: 160.00 pg/mL (mild reduced); Phosphorylated tau: 13.21 pg/mL (mild reduced). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The data shows mild ventricular enlargement and mild whole brain atrophy, but hippocampal, entorhinal cortex, fusiform gyrus, and middle temporal gyrus volumes are within normal ranges. The MMSE score of 28 is normal, and CSF biomarkers (Aβ normal, T-tau and P-tau mildly reduced) do not suggest Alzheimer’s pathology.  \n\n**Diagnosis:** CN (Cognitively Normal)  \n**Confidence:** Medium (due to mild structural changes despite normal cognitive and biomarker profiles)",
  "timestamp": "2025-07-26T02:41:35.245757"
}