{
  "ptid_time": "011_S_4366_2012-11-08",
  "img_path": "/data/qiuhui/data/adni/images/011_S_4366/2012-11-08/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 96,609 mm³, 150.8% above the reference mean. With a Z-score of 3.61 (100.0th percentile), this represents profound enlargement; hippocampal volume measures 5,605 mm³, 25.9% below the reference mean. With a Z-score of -2.52 (0.6th percentile), this represents significant atrophy; whole brain volume measures 1,104,730 mm³, 2.3% above the reference mean. With a Z-score of 0.30 (62.0th percentile), this represents normal volume ; entorhinal cortex volume measures 4,142 mm³, 1.0% above the reference mean. With a Z-score of 0.07 (52.7th percentile), this represents normal volume ; fusiform gyrus volume measures 18,460 mm³, 2.0% below the reference mean. With a Z-score of -0.17 (43.2th percentile), this represents normal volume ; middle temporal gyrus volume measures 18,267 mm³, 14.4% below the reference mean. With a Z-score of -1.29 (9.8th percentile), this represents mild atrophy. ",
  "text_data": "Age is 74.6 years. Gender is Male. Education: 16 years. MMSE: 15.0. MoCA: 12.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound ventricular enlargement (Z-score 3.61) and significant hippocampal atrophy (Z-score -2.52), both strong indicators of neurodegeneration. Combined with low MMSE (15) and MoCA (12) scores, this strongly suggests cognitive impairment beyond normal aging.  \n\n**Diagnosis:** **Dementia** (likely Alzheimer’s disease given hippocampal atrophy and APOE4 positivity).  \n\n**Confidence:** **High** (structural and cognitive deficits align with dementia, and APOE4 further supports AD pathology).",
  "timestamp": "2025-07-25T22:58:16.375308"
}