{
  "ptid_time": "141_S_0852_2006-09-25",
  "img_path": "/data/qiuhui/data/adni/images/141_S_0852/2006-09-25/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 19,619 mm³, 46.9% below the reference mean. With a Z-score of -1.27 (10.3th percentile), this represents mild atrophy; hippocampal volume measures 4,041 mm³, 37.8% below the reference mean. With a Z-score of -3.03 (0.1th percentile), this represents profound atrophy; whole brain volume measures 876,569 mm³, 5.6% below the reference mean. With a Z-score of -0.67 (25.2th percentile), this represents normal volume ; entorhinal cortex volume measures 1,928 mm³, 44.3% below the reference mean. With a Z-score of -2.39 (0.8th percentile), this represents significant atrophy; fusiform gyrus volume measures 14,607 mm³, 9.3% below the reference mean. With a Z-score of -0.70 (24.2th percentile), this represents normal volume ; middle temporal gyrus volume measures 16,783 mm³, 6.9% below the reference mean. With a Z-score of -0.61 (26.9th percentile), this represents normal volume . ",
  "text_data": "Age is 84.3 years. Gender is Female. Education: 18 years. Handedness: Unknown. Race: Unknown. Medical history: Psychiatric; Cardiovascular; Musculoskeletal; Endocrine-Metabolic. MMSE: 24.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 410.20 pg/mL (moderate reduced); Total tau: 362.10 pg/mL (moderate elevated); Phosphorylated tau: 34.90 pg/mL (moderate elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound atrophy in the hippocampus and significant atrophy in the entorhinal cortex, both key regions affected in Alzheimer's disease (AD). The moderate reduction in Aβ alongside elevated T-tau and P-tau levels further supports AD pathology. The MMSE score of 24 suggests mild cognitive impairment, consistent with early-stage dementia.  \n\n**Diagnosis:** Dementia (likely Alzheimer’s disease)  \n**Confidence:** High",
  "timestamp": "2025-07-26T16:50:40.761849"
}