{
  "ptid_time": "127_S_1419_2008-08-22",
  "img_path": "/data/qiuhui/data/adni/images/127_S_1419/2008-08-22/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 44,605 mm³, 15.8% above the reference mean. With a Z-score of 0.38 (64.8th percentile), this represents normal volume ; hippocampal volume measures 7,265 mm³, 3.9% below the reference mean. With a Z-score of -0.38 (35.2th percentile), this represents normal volume ; whole brain volume measures 1,161,200 mm³, 7.6% above the reference mean. With a Z-score of 0.98 (83.7th percentile), this represents normal volume ; entorhinal cortex volume measures 4,103 mm³, 0.1% above the reference mean. With a Z-score of 0.00 (50.2th percentile), this represents normal volume ; fusiform gyrus volume measures 21,828 mm³, 15.9% above the reference mean. With a Z-score of 1.35 (91.2th percentile), this represents mild enlargement; middle temporal gyrus volume measures 22,704 mm³, 6.4% above the reference mean. With a Z-score of 0.58 (71.7th percentile), this represents normal volume . ",
  "text_data": "Age is 78.9 years. Gender is Male. Education: 17 years. MMSE: 29.0. Logical Memory: 1.0. APOEε4 alleles: 1.0. Biomarker levels: Pittsburgh compound B: 2.14 SUVR (mild elevated); Amyloid beta: 400.50 pg/mL (moderate reduced); Total tau: 230.50 pg/mL (normal ); Phosphorylated tau: 21.94 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The brain volume measurements are largely within normal ranges, with only mild deviations (e.g., hippocampal volume slightly below mean but still normal). The MMSE score of 29 is within the normal range, and while Aβ is moderately reduced (suggesting amyloid pathology), tau markers (T-tau, P-tau) are normal. This pattern is more consistent with early amyloid deposition without significant neurodegeneration or cognitive impairment.  \n\n**Diagnosis:** **CN (Cognitively Normal)**  \n**Confidence:** **Medium** (due to the presence of reduced Aβ, which may indicate preclinical Alzheimer’s pathology, but no functional or structural deficits yet)",
  "timestamp": "2025-07-26T13:08:27.665325"
}