{
  "ptid_time": "002_S_0619_2006-06-01",
  "img_path": "/data/qiuhui/data/adni/images/002_S_0619/2006-06-01/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 109,900 mm³, 185.3% above the reference mean. With a Z-score of 4.44 (100.0th percentile), this represents profound enlargement; hippocampal volume measures 5,812 mm³, 23.1% below the reference mean. With a Z-score of -2.25 (1.2th percentile), this represents significant atrophy; whole brain volume measures 1,075,140 mm³, 0.4% below the reference mean. With a Z-score of -0.05 (48.0th percentile), this represents normal volume ; entorhinal cortex volume measures 2,773 mm³, 32.4% below the reference mean. With a Z-score of -2.20 (1.4th percentile), this represents significant atrophy; fusiform gyrus volume measures 20,675 mm³, 9.7% above the reference mean. With a Z-score of 0.83 (79.7th percentile), this represents normal volume ; middle temporal gyrus volume measures 19,959 mm³, 6.5% below the reference mean. With a Z-score of -0.58 (28.1th percentile), this represents normal volume . ",
  "text_data": "Age is 77.5 years. Gender is Male. Education: 12 years. Handedness: Right. Race: White. Medical history: Psychiatric; Neurologic; Respiratory; Musculoskeletal; Allergies or Drug Sensitivities; Alcohol Abuse; Smoking; Major Surgical Procedures. MMSE: 22.0. Logical Memory: 0.0. APOEε4 alleles: 2.0. Biomarker levels: Amyloid beta: 393.80 pg/mL (moderate reduced); Total tau: 212.40 pg/mL (normal ); Phosphorylated tau: 18.56 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound ventricular enlargement (Z-score 4.44) and significant atrophy in the hippocampus (Z-score -2.25) and entorhinal cortex (Z-score -2.20), which are hallmark structural changes in Alzheimer’s disease (AD). The MMSE score of 22 indicates cognitive impairment, and the presence of two APOE4 alleles along with moderately reduced Aβ (likely amyloid positivity) further supports AD pathology.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-25T20:02:54.614171"
}