{
  "ptid_time": "027_S_1082_2008-12-15",
  "img_path": "/data/qiuhui/data/adni/images/027_S_1082/2008-12-15/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 58,976 mm³, 110.1% above the reference mean. With a Z-score of 2.52 (99.4th percentile), this represents significant enlargement; hippocampal volume measures 4,248 mm³, 40.3% below the reference mean. With a Z-score of -3.70 (0.0th percentile), this represents profound atrophy; whole brain volume measures 831,914 mm³, 14.6% below the reference mean. With a Z-score of -1.84 (3.3th percentile), this represents moderate atrophy; entorhinal cortex volume measures 1,703 mm³, 53.6% below the reference mean. With a Z-score of -3.29 (0.0th percentile), this represents profound atrophy; fusiform gyrus volume measures 9,893 mm³, 41.9% below the reference mean. With a Z-score of -3.81 (0.0th percentile), this represents profound atrophy; middle temporal gyrus volume measures 12,254 mm³, 36.1% below the reference mean. With a Z-score of -3.13 (0.1th percentile), this represents profound atrophy. ",
  "text_data": "Age is 71.5 years. Gender is Female. Education: 13 years. MMSE: 5.0. Logical Memory: 0.0. APOEε4 alleles: 2.0. Biomarker levels: Amyloid beta: 359.60 pg/mL (moderate reduced); Total tau: 317.70 pg/mL (normal ); Phosphorylated tau: 27.84 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound atrophy in key Alzheimer's-related regions (hippocampus, entorhinal cortex, fusiform gyrus, middle temporal gyrus) alongside significant ventricular enlargement, consistent with advanced neurodegeneration. The MMSE score of 5.0 indicates severe cognitive impairment, and the presence of two APOE4 alleles with moderately reduced Aβ further supports Alzheimer's pathology.  \n\n**Diagnosis:** **Dementia** (likely Alzheimer’s disease)  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T03:47:22.025943"
}