{
  "ptid_time": "067_S_0336_2007-05-21",
  "img_path": "/data/qiuhui/data/adni/images/067_S_0336/2007-05-21/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 29,868 mm³, 22.5% below the reference mean. With a Z-score of -0.54 (29.5th percentile), this represents normal volume ; hippocampal volume measures 5,011 mm³, 33.7% below the reference mean. With a Z-score of -3.29 (0.1th percentile), this represents profound atrophy; whole brain volume measures 949,874 mm³, 12.0% below the reference mean. With a Z-score of -1.56 (6.0th percentile), this represents moderate atrophy; entorhinal cortex volume measures 2,870 mm³, 30.0% below the reference mean. With a Z-score of -2.04 (2.1th percentile), this represents significant atrophy; fusiform gyrus volume measures 11,971 mm³, 36.5% below the reference mean. With a Z-score of -3.11 (0.1th percentile), this represents profound atrophy; middle temporal gyrus volume measures 13,228 mm³, 38.0% below the reference mean. With a Z-score of -3.42 (0.0th percentile), this represents profound atrophy. ",
  "text_data": "Age is 77.1 years. Gender is Male. Education: 17 years. MMSE: 21.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 624.80 pg/mL (mild reduced); Total tau: 435.00 pg/mL (significant elevated); Phosphorylated tau: 45.07 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound atrophy in key Alzheimer's-related regions (hippocampus, fusiform gyrus, middle temporal gyrus) alongside significant entorhinal cortex atrophy and moderate whole-brain atrophy. Elevated tau biomarkers (T-tau, P-tau) and mildly reduced Aβ support Alzheimer's pathology. The MMSE score of 21 indicates cognitive impairment.  \n\n**Diagnosis:** **Dementia** (likely Alzheimer’s disease)  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T08:30:09.526416"
}