{
  "ptid_time": "041_S_1010_2007-12-04",
  "img_path": "/data/qiuhui/data/adni/images/041_S_1010/2007-12-04/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 58,146 mm³, 51.0% above the reference mean. With a Z-score of 1.22 (88.9th percentile), this represents mild enlargement; hippocampal volume measures 5,132 mm³, 32.1% below the reference mean. With a Z-score of -3.13 (0.1th percentile), this represents profound atrophy; whole brain volume measures 1,110,310 mm³, 2.9% above the reference mean. With a Z-score of 0.37 (64.5th percentile), this represents normal volume ; entorhinal cortex volume measures 2,656 mm³, 35.2% below the reference mean. With a Z-score of -2.39 (0.8th percentile), this represents significant atrophy; fusiform gyrus volume measures 15,693 mm³, 16.7% below the reference mean. With a Z-score of -1.42 (7.7th percentile), this represents mild atrophy; middle temporal gyrus volume measures 21,929 mm³, 2.8% above the reference mean. With a Z-score of 0.25 (59.8th percentile), this represents normal volume . ",
  "text_data": "Age is 75.2 years. Gender is Male. Education: 20 years. MMSE: 27.0. Logical Memory: 6.0. APOEε4 alleles: 1.0. Biomarker levels: Pittsburgh compound B: 1.98 SUVR (mild elevated); Amyloid beta: 381.00 pg/mL (moderate reduced); Total tau: 303.60 pg/mL (normal ); Phosphorylated tau: 27.01 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound hippocampal atrophy (Z-score -3.13) and significant entorhinal cortex atrophy (Z-score -2.39), both strongly associated with Alzheimer's pathology. The MMSE of 27 is near-normal, but the presence of moderate Aβ reduction suggests amyloid pathology. The combination of structural atrophy and biomarker evidence points to early neurodegeneration.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI)** (likely due to Alzheimer's pathology)  \n**Confidence:** **High** (due to clear hippocampal/entorhinal atrophy and amyloid changes, despite relatively preserved MMSE)",
  "timestamp": "2025-07-26T07:03:23.699025"
}