{
  "ptid_time": "022_S_0129_2007-02-26",
  "img_path": "/data/qiuhui/data/adni/images/022_S_0129/2007-02-26/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 45,963 mm³, 24.3% above the reference mean. With a Z-score of 0.66 (74.4th percentile), this represents normal volume ; hippocampal volume measures 4,201 mm³, 35.3% below the reference mean. With a Z-score of -2.83 (0.2th percentile), this represents significant atrophy; whole brain volume measures 835,313 mm³, 10.0% below the reference mean. With a Z-score of -1.20 (11.5th percentile), this represents mild atrophy; entorhinal cortex volume measures 1,678 mm³, 51.5% below the reference mean. With a Z-score of -2.78 (0.3th percentile), this represents significant atrophy; fusiform gyrus volume measures 12,218 mm³, 24.2% below the reference mean. With a Z-score of -1.82 (3.5th percentile), this represents moderate atrophy; middle temporal gyrus volume measures 14,759 mm³, 18.1% below the reference mean. With a Z-score of -1.61 (5.3th percentile), this represents moderate atrophy. ",
  "text_data": "Age is 81.2 years. Gender is Female. Education: 16 years. MMSE: 23.0. Logical Memory: 0.0. APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 590.30 pg/mL (mild reduced); Total tau: 288.30 pg/mL (normal ); Phosphorylated tau: 28.02 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows significant atrophy in the hippocampus and entorhinal cortex, which are key regions affected in Alzheimer's disease (AD), along with moderate atrophy in the fusiform gyrus and middle temporal gyrus. The MMSE score of 23 suggests mild cognitive impairment, and the mildly reduced Aβ (amyloid-beta) supports AD pathology, despite normal tau levels.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI) due to Alzheimer’s disease**  \n**Confidence:** **Medium** (due to the absence of severe cognitive decline but clear structural and biomarker evidence of AD-related changes)",
  "timestamp": "2025-07-26T02:01:32.735855"
}