{
  "ptid_time": "022_S_1097_2006-11-30",
  "img_path": "/data/qiuhui/data/adni/images/022_S_1097/2006-11-30/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 28,917 mm³, 24.9% below the reference mean. With a Z-score of -0.60 (27.5th percentile), this represents normal volume ; hippocampal volume measures 5,779 mm³, 23.5% below the reference mean. With a Z-score of -2.30 (1.1th percentile), this represents significant atrophy; whole brain volume measures 982,015 mm³, 9.0% below the reference mean. With a Z-score of -1.17 (12.1th percentile), this represents mild atrophy; entorhinal cortex volume measures 3,509 mm³, 14.4% below the reference mean. With a Z-score of -0.98 (16.4th percentile), this represents normal volume ; fusiform gyrus volume measures 16,513 mm³, 12.3% below the reference mean. With a Z-score of -1.05 (14.7th percentile), this represents mild atrophy; middle temporal gyrus volume measures 18,226 mm³, 14.6% below the reference mean. With a Z-score of -1.31 (9.5th percentile), this represents mild atrophy. ",
  "text_data": "Age is 73.0 years. Gender is Male. Education: 18 years. Handedness: Right. Race: White. Medical history: Head, Eyes, Ears, Nose and Throat; Dermatologic-Connective Tissue; Smoking. MMSE: 25.0. Logical Memory: 1.0. APOEε4 alleles: 0.0. Biomarker levels: Amyloid beta: 775.60 pg/mL (normal ); Total tau: 477.60 pg/mL (significant elevated); Phosphorylated tau: 50.89 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "Reasoning: The hippocampal volume shows significant atrophy (Z-score -2.30, 1.1th percentile), which is a strong biomarker for Alzheimer's disease (AD). Elevated T-tau and P-tau levels further support AD pathology, despite normal Aβ levels (suggesting possible non-amyloid AD or tauopathy). The MMSE score of 25 indicates mild cognitive impairment.  \nDiagnosis: Dementia (likely Alzheimer’s disease)  \nConfidence: Medium (due to conflicting Aβ result but strong tau and hippocampal atrophy markers)",
  "timestamp": "2025-07-26T02:08:23.395180"
}