{
  "ptid_time": "094_S_1027_2007-05-14",
  "img_path": "/data/qiuhui/data/adni/images/094_S_1027/2007-05-14/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 24,402 mm³, 9.2% above the reference mean. With a Z-score of 0.23 (59.1th percentile), this represents normal volume ; hippocampal volume measures 4,899 mm³, 36.2% below the reference mean. With a Z-score of -4.07 (0.0th percentile), this represents profound atrophy; whole brain volume measures 867,845 mm³, 15.7% below the reference mean. With a Z-score of -1.95 (2.6th percentile), this represents moderate atrophy; entorhinal cortex volume measures 2,731 mm³, 29.8% below the reference mean. With a Z-score of -2.31 (1.0th percentile), this represents significant atrophy; fusiform gyrus volume measures 12,779 mm³, 29.8% below the reference mean. With a Z-score of -3.36 (0.0th percentile), this represents profound atrophy; middle temporal gyrus volume measures 16,617 mm³, 19.0% below the reference mean. With a Z-score of -1.69 (4.5th percentile), this represents moderate atrophy. ",
  "text_data": "Age is 69.6 years. Gender is Female. Education: 12 years. MMSE: 25.0. APOEε4 alleles: 2.0. ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The imaging data shows profound atrophy in the hippocampus and fusiform gyrus, significant atrophy in the entorhinal cortex, and moderate atrophy in the whole brain and middle temporal gyrus—all key regions affected in Alzheimer’s disease (AD). The MMSE score of 25 is borderline but aligns with early cognitive impairment, and the presence of two APOE4 alleles further increases AD risk.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**  \n\n*(Rationale: Severe medial temporal lobe atrophy + APOE4 homozygosity + borderline MMSE strongly suggest neurodegenerative dementia, with AD as the most probable etiology.)*",
  "timestamp": "2025-07-26T10:15:01.315499"
}