{
  "ptid_time": "037_S_4015_2015-04-08",
  "img_path": "/data/qiuhui/data/adni/images/037_S_4015/2015-04-08/t1.nii.gz",
  "img_finding": "Image findings: hippocampal volume measures 4,144 mm³, 41.8% below the reference mean. With a Z-score of -3.83 (0.0th percentile), this represents profound atrophy; whole brain volume measures 934,829 mm³, 4.1% below the reference mean. With a Z-score of -0.51 (30.3th percentile), this represents normal volume . ",
  "text_data": "Age is 77.6 years. Gender is Female. Education: 20 years. MMSE: 12.0. APOEε4 alleles: 1.0. Biomarker levels: Florbetapir (AV45): 1.68 SUVR (profound elevated); Amyloid beta: 318.60 pg/mL (moderate reduced); Total tau: 406.70 pg/mL (significant elevated); Phosphorylated tau: 35.05 pg/mL (moderate elevated). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The hippocampal volume shows profound atrophy (Z-score -3.83, 0.0th percentile), strongly indicative of neurodegeneration, while whole brain volume remains within normal limits. Combined with significantly elevated biomarkers (Aβ, T-tau, P-tau, AV45) and a very low MMSE score (12/30), this strongly suggests advanced cognitive impairment.  \n\n**Diagnosis:** **Dementia** (likely Alzheimer’s disease given biomarker profile and hippocampal atrophy).  \n**Confidence:** **High** (severe hippocampal atrophy, biomarker evidence, and low MMSE align with dementia diagnosis).",
  "timestamp": "2025-07-26T06:38:58.826217"
}