{
  "ptid_time": "123_S_4096_2011-07-28",
  "img_path": "/data/qiuhui/data/adni/images/123_S_4096/2011-07-28/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 50,323 mm³, 7.0% above the reference mean. With a Z-score of 0.20 (58.1th percentile), this represents normal volume ; hippocampal volume measures 5,248 mm³, 24.7% below the reference mean. With a Z-score of -2.13 (1.6th percentile), this represents significant atrophy; whole brain volume measures 969,532 mm³, 5.8% below the reference mean. With a Z-score of -0.76 (22.4th percentile), this represents normal volume ; entorhinal cortex volume measures 2,513 mm³, 36.7% below the reference mean. With a Z-score of -2.40 (0.8th percentile), this represents significant atrophy; fusiform gyrus volume measures 19,413 mm³, 7.5% above the reference mean. With a Z-score of 0.65 (74.1th percentile), this represents normal volume ; middle temporal gyrus volume measures 18,118 mm³, 10.2% below the reference mean. With a Z-score of -0.91 (18.1th percentile), this represents normal volume . ",
  "text_data": "Age is 84.5 years. Gender is Male. Education: 9 years. Handedness: Right. Race: White. Medical history: Cardiovascular; Dermatologic-Connective Tissue; Gastrointestinal; Renal-Genitourinary; Smoking; Malignancy; Major Surgical Procedures. MMSE: 24.0. MoCA: 17.0. Logical Memory: 0.0. Laboratory findings: Creatine Kinase: 364.00 (profound elevated); LDH: 241.00 (significant elevated). APOEε4 alleles: 2.0. Biomarker levels: Florbetapir (AV45): 1.33 SUVR (moderate elevated); Amyloid beta: 267.20 pg/mL (moderate reduced); Total tau: 204.50 pg/mL (normal ); Phosphorylated tau: 20.04 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "Reasoning: The hippocampal and entorhinal cortex volumes show significant atrophy (Z-scores of -2.13 and -2.40, respectively), which are key biomarkers for Alzheimer's disease. The MMSE of 24 and MoCA of 17 indicate cognitive impairment, and the presence of two APOE4 alleles along with moderately reduced Aβ and elevated AV45 further support an Alzheimer's pathology.  \n\nDiagnosis: Dementia (likely Alzheimer's disease)  \nConfidence: High",
  "timestamp": "2025-07-26T12:31:01.770670"
}