{
  "ptid_time": "033_S_0739_2008-08-25",
  "img_path": "/data/qiuhui/data/adni/images/033_S_0739/2008-08-25/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 51,848 mm³, 10.3% above the reference mean. With a Z-score of 0.30 (61.7th percentile), this represents normal volume ; hippocampal volume measures 4,680 mm³, 32.8% below the reference mean. With a Z-score of -2.84 (0.2th percentile), this represents significant atrophy; whole brain volume measures 978,168 mm³, 5.0% below the reference mean. With a Z-score of -0.65 (25.8th percentile), this represents normal volume ; entorhinal cortex volume measures 2,495 mm³, 37.1% below the reference mean. With a Z-score of -2.43 (0.8th percentile), this represents significant atrophy; fusiform gyrus volume measures 16,636 mm³, 7.9% below the reference mean. With a Z-score of -0.69 (24.7th percentile), this represents normal volume ; middle temporal gyrus volume measures 18,229 mm³, 9.6% below the reference mean. With a Z-score of -0.86 (19.4th percentile), this represents normal volume . ",
  "text_data": "Age is 84.8 years. Gender is Male. Education: 15 years. MMSE: 22.0. Logical Memory: 1.0. APOEε4 alleles: 1.0. Biomarker levels: Amyloid beta: 1054.00 pg/mL (normal ); Total tau: 435.60 pg/mL (significant elevated); Phosphorylated tau: 41.32 pg/mL (significant elevated). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The patient shows significant atrophy in the hippocampus and entorhinal cortex (both with Z-scores < -2.0), which are key regions affected in Alzheimer's disease. Elevated T-tau and P-tau with normal Aβ suggest tauopathy consistent with AD, while the MMSE score of 22 indicates cognitive impairment.  \n\n**Diagnosis:** **Dementia (likely Alzheimer’s disease)**  \n**Confidence:** **High**",
  "timestamp": "2025-07-26T05:18:47.892747"
}