{
  "ptid_time": "094_S_1398_2007-11-15",
  "img_path": "/data/qiuhui/data/adni/images/094_S_1398/2007-11-15/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 46,240 mm³, 64.7% above the reference mean. With a Z-score of 1.48 (93.1th percentile), this represents mild enlargement; hippocampal volume measures 3,450 mm³, 51.5% below the reference mean. With a Z-score of -4.72 (0.0th percentile), this represents profound atrophy; whole brain volume measures 676,349 mm³, 30.6% below the reference mean. With a Z-score of -3.85 (0.0th percentile), this represents profound atrophy; entorhinal cortex volume measures 1,590 mm³, 56.7% below the reference mean. With a Z-score of -3.48 (0.0th percentile), this represents profound atrophy; fusiform gyrus volume measures 11,509 mm³, 32.4% below the reference mean. With a Z-score of -2.94 (0.2th percentile), this represents significant atrophy; middle temporal gyrus volume measures 11,652 mm³, 39.2% below the reference mean. With a Z-score of -3.40 (0.0th percentile), this represents profound atrophy. ",
  "text_data": "Age is 78.1 years. Gender is Female. Education: 16 years. MMSE: 18.0. APOEε4 alleles: 1.0. ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound atrophy in multiple brain regions critical for memory and cognition (hippocampus, entorhinal cortex, middle temporal gyrus) alongside significant whole-brain volume loss. The MMSE score of 18 indicates moderate cognitive impairment, and the presence of one APOE4 allele increases Alzheimer's risk.  \n\n**Diagnosis:** **Dementia** (likely Alzheimer’s disease given the pattern of atrophy and APOE4 status).  \n\n**Confidence:** **High** (severe atrophy in AD-vulnerable regions, low MMSE, and supportive genetic risk).",
  "timestamp": "2025-07-26T10:23:24.826677"
}