{
  "ptid_time": "027_S_0256_2010-04-15",
  "img_path": "/data/qiuhui/data/adni/images/027_S_0256/2010-04-15/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 60,141 mm³, 56.1% above the reference mean. With a Z-score of 1.34 (91.1th percentile), this represents mild enlargement; hippocampal volume measures 4,322 mm³, 42.8% below the reference mean. With a Z-score of -4.18 (0.0th percentile), this represents profound atrophy; whole brain volume measures 935,014 mm³, 13.4% below the reference mean. With a Z-score of -1.74 (4.1th percentile), this represents moderate atrophy; entorhinal cortex volume measures 2,343 mm³, 42.9% below the reference mean. With a Z-score of -2.91 (0.2th percentile), this represents significant atrophy; fusiform gyrus volume measures 15,363 mm³, 18.4% below the reference mean. With a Z-score of -1.57 (5.8th percentile), this represents moderate atrophy; middle temporal gyrus volume measures 14,690 mm³, 31.2% below the reference mean. With a Z-score of -2.80 (0.3th percentile), this represents significant atrophy. ",
  "text_data": "Age is 74.1 years. Gender is Male. Education: 20 years. MMSE: 15.0. Logical Memory: 2.0. APOEε4 alleles: 2.0. Biomarker levels: Amyloid beta: 289.20 pg/mL (moderate reduced); Total tau: 263.70 pg/mL (normal ); Phosphorylated tau: 25.40 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: AD.",
  "gpt_diagnosis": "**Reasoning:** The data shows profound hippocampal atrophy (Z-score -4.18), significant entorhinal cortex and middle temporal gyrus atrophy, and moderate whole-brain atrophy, all strongly suggestive of Alzheimer's pathology. The MMSE score of 15 indicates significant cognitive impairment, and the presence of two APOE4 alleles along with moderately reduced Aβ further supports an Alzheimer's diagnosis.  \n\n**Diagnosis:** Dementia (likely Alzheimer’s disease)  \n**Confidence:** High",
  "timestamp": "2025-07-26T03:32:31.552752"
}