{
  "ptid_time": "126_S_4712_2012-05-08",
  "img_path": "/data/qiuhui/data/adni/images/126_S_4712/2012-05-08/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 25,147 mm³, 34.7% below the reference mean. With a Z-score of -0.83 (20.3th percentile), this represents normal volume ; whole brain volume measures 1,078,320 mm³, 0.1% below the reference mean. With a Z-score of -0.01 (49.5th percentile), this represents normal volume ; entorhinal cortex volume measures 2,908 mm³, 29.1% below the reference mean. With a Z-score of -1.97 (2.4th percentile), this represents moderate atrophy; fusiform gyrus volume measures 18,580 mm³, 1.4% below the reference mean. With a Z-score of -0.12 (45.3th percentile), this represents normal volume ; middle temporal gyrus volume measures 19,486 mm³, 8.7% below the reference mean. With a Z-score of -0.78 (21.8th percentile), this represents normal volume . ",
  "text_data": "Age is 74.3 years. Gender is Male. Education: 17 years. Handedness: Right. Race: White. Medical history: Psychiatric; Head, Eyes, Ears, Nose and Throat; Cardiovascular; Respiratory; Hepatic; Dermatologic-Connective Tissue; Musculoskeletal; Hematopoietic-Lymphatic; Renal-Genitourinary; Malignancy; Major Surgical Procedures. MMSE: 24.0. MoCA: 22.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Florbetapir (AV45): 1.30 SUVR (moderate elevated); Amyloid beta: 1127.00 pg/mL (normal ); Total tau: 513.70 pg/mL (profound elevated); Phosphorylated tau: 51.87 pg/mL (profound elevated). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "Reasoning: The entorhinal cortex shows moderate atrophy (Z-score -1.97, 2.4th percentile), which is a key early marker of Alzheimer's pathology. Elevated T-tau and P-tau with normal Aβ suggest tauopathy without amyloidosis, possibly atypical AD or primary age-related tauopathy (PART). MMSE and MoCA scores indicate mild cognitive impairment.  \nDiagnosis: MCI (likely due to underlying tauopathy)  \nConfidence: Medium (atypical biomarker profile warrants caution)",
  "timestamp": "2025-07-26T12:49:24.915585"
}