{
  "ptid_time": "007_S_4611_2016-04-26",
  "img_path": "/data/qiuhui/data/adni/images/007_S_4611/2016-04-26/t1.nii.gz",
  "img_finding": "Image findings: ventricular volume measures 52,684 mm³, 36.8% above the reference mean. With a Z-score of 0.88 (81.1th percentile), this represents normal volume ; hippocampal volume measures 6,077 mm³, 19.6% below the reference mean. With a Z-score of -1.91 (2.8th percentile), this represents moderate atrophy; whole brain volume measures 1,010,900 mm³, 6.3% below the reference mean. With a Z-score of -0.82 (20.5th percentile), this represents normal volume ; entorhinal cortex volume measures 3,266 mm³, 20.4% below the reference mean. With a Z-score of -1.38 (8.4th percentile), this represents mild atrophy; fusiform gyrus volume measures 20,372 mm³, 8.1% above the reference mean. With a Z-score of 0.69 (75.6th percentile), this represents normal volume ; middle temporal gyrus volume measures 18,239 mm³, 14.5% below the reference mean. With a Z-score of -1.31 (9.6th percentile), this represents mild atrophy. ",
  "text_data": "Age is 70.9 years. Gender is Male. Education: 18 years. MMSE: 25.0. MoCA: 22.0. Logical Memory: 0.0. APOEε4 alleles: 1.0. Biomarker levels: Florbetapir (AV45): 1.32 SUVR (moderate elevated); Amyloid beta: 455.40 pg/mL (mild reduced); Total tau: 227.60 pg/mL (normal ); Phosphorylated tau: 23.10 pg/mL (normal ). ",
  "true_diagnosis": "Diagnosis: MCI.",
  "gpt_diagnosis": "**Reasoning:** The patient shows moderate hippocampal atrophy and mild atrophy in the entorhinal cortex and middle temporal gyrus, which are key regions affected in Alzheimer's disease. The MMSE (25) and MoCA (22) scores suggest mild cognitive impairment, supported by moderately elevated amyloid (AV45) and mildly reduced Aβ, but normal tau levels.  \n\n**Diagnosis:** **Mild Cognitive Impairment (MCI)** (likely due to Alzheimer’s pathology)  \n**Confidence:** **Medium** (due to borderline cognitive scores and mixed biomarker profile—amyloid elevation without significant tauopathy)",
  "timestamp": "2025-07-25T22:04:09.386475"
}