```python
from shiny import App, render, ui
from shiny.types import Inputs

def server(input: Inputs, output, session):
    @render(ui)
    def _manage_inputs():
        # Assuming the logic to update inputs based on the first two inputs
        val1 = input.input1
        val2 = input.input2
        # Update logic for inputs in second and third columns based on val1 and val2
        # This is a placeholder logic, replace with actual logic as needed
        inputs_second_column = {"input3": f"Updated by {val1}", "input4": f"Updated by {val2}"}
        inputs_third_column = {"input5": f"Controlled by {val1} and {val2}", "tabset1": "Dynamic Content"}
        return ui.div(
            ui.column(4, ui.output_ui("input3"), ui.output_ui("input4")),
            ui.column(4, ui.output_ui("input5"), ui.tabset_panel(ui.tab_panel("Tab 1", "Content 1", id="tabset1")))
        )

app = App(
    ui=ui.page_fluid(
        ui.row(
            ui.column(4, 
                      ui.input_text("input1", "Input 1"),
                      ui.input_text("input2", "Input 2")),
            ui.column(4, 
                      ui.input_text("input3", "Input 3", disabled=True),
                      ui.input_text("input4", "Input 4", disabled=True)),
            ui.column(4, 
                      ui.input_text("input5", "Input 5", disabled=True),
                      ui.tabset_panel(ui.tab_panel("Tab 1", "Content for tab 1", id="tab1")))
        )
    ),
    server=server,
    debug=True
)

if __name__ == "__main__":
    app.run()
```