1.1.2|[P:2]-[O&H0&+0&D2:1]-C>>[P:2]-[O&H0&-&D1:1]|[Na+:1].C[O:2][P:3](=[O:4])([O:5][CH2:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[O:14][CH2:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1.[OH-]>CO.CC#N.C[Si](C)(C)Br>[Na+:1].[O-:2][P:3](=[O:4])([O:5][CH2:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[O:14][CH2:15][CH2:16][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|US10093688B2_0394
6.2.2|[C:2]-[O&H0&+0&D2:1]-C>>[C:2]-[O&H0&-&D1:1]|[Na+:1].CO.C[O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][n:10]1)[S:11](=[O:12])[CH2:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[Cl:20].[OH-]>>[Na+:1].[O-:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][n:10]1)[S:11](=[O:12])[CH2:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[Cl:20]|US07432269B2_0400
9.7.334|[c:2]-[N&H1&+0&D2:1]-C>>[c:2]-[N&H2&+0&D1:1]|C[NH:1][c:2]1[n:3][c:4]([n:5][c:6]([n:7]1)[C:8]([Cl:9])([Cl:10])[Cl:11])[NH:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>N.CN>[NH2:1][c:2]1[n:3][c:4]([n:5][c:6]([n:7]1)[C:8]([Cl:9])([Cl:10])[Cl:11])[NH:12][CH2:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|US09133174B2_0167
9.7.148|[C:2]-[N&H0&+0&D2:1]=C>>[C:2]-[N&H2&+0&D1:1]|C=[N:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([n:7][cH:8]1)[Cl:9]>O.Cl.Cc1ccccc1>[NH2:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([n:7][cH:8]1)[Cl:9]|US05126426A
7.9.11|[N:2]-[N&H0&+0&D2:1]=O>>[N:2]-[N&H2&+0&D1:1]|[CH3:1][C:2]1([CH2:3][S:4]([CH2:5][C:6]([N:7]1[N:8]=O)([CH3:9])[CH3:10])(=[O:11])=[O:12])[CH3:13]>CC(=O)O.O.[Zn]>[CH3:1][C:2]1([CH2:3][S:4]([CH2:5][C:6]([N:7]1[NH2:8])([CH3:9])[CH3:10])(=[O:11])=[O:12])[CH3:13]|US20040106635A1_0730
9.7.141|[C:2]-[C&H2&+0&D2:1]-I>>[C:2]-[C&H3&+0&D1:1]|[CH3:1][C@@:2]12[CH:3]=[CH:4][C:5]([CH:6]=[C:7]2[CH2:8][CH2:9][C@H:10]2[C@@H:11]3[CH2:12][CH:13]=[C:14]([C@:15]3([CH2:16][C@@H:17]([C@@:18]21[F:19])[OH:20])[CH3:21])[C:22](=[O:23])[CH2:24]I)=[O:25]>O.O=S(O)O[Na].C1COCCO1>[CH3:24][C:22](=[O:23])[C:14]1=[CH:13][CH2:12][C@H:11]2[C@@H:10]3[CH2:9][CH2:8][C:7]4=[CH:6][C:5]([CH:4]=[CH:3][C@@:2]4([C@:18]3([C@H:17]([CH2:16][C@:15]12[CH3:21])[OH:20])[F:19])[CH3:1])=[O:25]|US06235750B1
9.7.60|[C:2]-[C&H2&+0&D2:1]-O>>[C:2]-[C&H3&+0&D1:1]|[CH2:1]=[CH:2][CH2:3][NH:4][C:5](=[O:6])[CH2:7][O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[O:15][CH2:16][CH:17]([OH:18])[CH2:19][NH:20][C:21]([CH3:22])([CH3:23])[CH2:24]O>>[CH2:1]=[CH:2][CH2:3][NH:4][C:5](=[O:6])[CH2:7][O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[O:15][CH2:16][CH:17]([OH:18])[CH2:19][NH:20][C:21]([CH3:24])([CH3:23])[CH3:22]|US07078405B2_0488
9.7.334|[S:2]-[N&H1&+0&D2:1]-C>>[S:2]-[N&H2&+0&D1:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])[S:11](=[O:12])(=[O:13])[NH:14]C>CN>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])[S:11]([NH2:14])(=[O:12])=[O:13]|US06548671B2
9.7.334|[N:2]-[N&H1&+0&D2:1]-C>>[N:2]-[N&H2&+0&D1:1]|C[NH:1][NH:2][C:3]([CH3:4])=[O:5]>>[CH3:4][C:3](=[O:5])[NH:2][NH2:1]|US20190337950A1_0473
9.7.140|[C:2]-[C&H2&+0&D2:1]-F>>[C:2]-[C&H3&+0&D1:1]|[O:1]=[C:2]([CH2:3]F)[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1>CC(=O)N(C)C.O=C(O[K])O[K]>[CH3:3][C:2](=[O:1])[c:4]1[cH:9][cH:8][cH:7][cH:6][cH:5]1|US09296722B2_0920
6.3.7|[c:2]-[O&H0&+0&D2:1]-C>>[c:2]-[O&H1&+0&D1:1]|[CH3:1][CH:2]([CH3:3])[C:4]1([CH2:5][c:6]2[cH:7][c:8]([c:9]([c:10]([c:11]2[C:12]1=[O:13])[Cl:14])[Cl:15])[O:16]C)[CH3:17]>CCCCCCC.Cl[Al](Cl)Cl>[CH3:1][CH:2]([CH3:3])[C:4]1([CH2:5][c:6]2[cH:7][c:8]([c:9]([c:10]([c:11]2[C:12]1=[O:13])[Cl:14])[Cl:15])[OH:16])[CH3:17]|EP1007528B1_0043
7.9.5|[c:2]-[N&H0&+0&D2:1]=O>>[c:2]-[N&H2&+0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1-[c:9]1[n:10][c:11]([c:12]([c:13]([nH:14]1)=[O:15])[N:16]=O)[NH2:17]>O.[Na+].[Na+].[O-]S(=O)S([O-])=O>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1-[c:9]1[n:10][c:11]([c:12]([c:13]([nH:14]1)=[O:15])[NH2:16])[NH2:17]|US04335119A
6.2.2|[C:2]-[O&H0&+0&D2:1]-C>>[C:2]-[O&H1&+0&D1:1]|[CH3:1][C:2]1([S:3][CH2:4][CH2:5][c:6]2[c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[nH:13][c:14]21)[CH2:15][C:16](=[O:17])[O:18]C>[OH-].[K+]>[CH3:1][C:2]1([S:3][CH2:4][CH2:5][c:6]2[c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[nH:13][c:14]21)[CH2:15][C:16](=[O:17])[OH:18]|US05430051A
7.9.19|[C:2]-[C&H1&+0&D2:1]=O>>[C:2]-[C&H3&+0&D1:1]|[O:1]=[C:2]1[CH2:3][CH2:4][C:5]([CH2:6][CH2:7]1)([CH:8]=O)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>O.NN.OCCO.O[K]>[CH3:8][C:5]1([CH2:4][CH2:3][C:2]([CH2:7][CH2:6]1)=[O:1])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|EP0945441A2_0031
9.7.147|[c:2]-[C&H2&+0&D2:1]-N>>[c:2]-[C&H3&+0&D1:1]|[CH3:1][n:2]1[c:3]([n:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[c:11]1=[O:12])[CH2:13]N)[CH3:14]>>[CH3:13][c:8]1[cH:7][cH:6][c:5]2[n:4][c:3]([n:2]([c:11]([c:10]2[cH:9]1)=[O:12])[CH3:1])[CH3:14]|US09181182B2_0267
7.9.19|[c:2]-[C&H1&+0&D2:1]=O>>[c:2]-[C&H3&+0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH:11]=O>NN.OCCO.[OH-].[K+]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH3:11]|US08012976B2_0933
9.7.334|[C:2]-[N&H1&+0&D2:1]-C>>[C:2]-[N&H2&+0&D1:1]|C[NH:1][CH2:2][C@H:3]([OH:4])[C@@H:5]([OH:6])[C@H:7]([OH:8])[C@H:9]([OH:10])[CH2:11][OH:12]>CO>[NH2:1][CH2:2][C@H:3]([OH:4])[C@@H:5]([OH:6])[C@H:7]([OH:8])[C@H:9]([OH:10])[CH2:11][OH:12]|US05143912A
4.2.8|[C:2]-[O&H0&+0&D2:1]-O>>[C:2]-[O&H1&+0&D1:1]|[O:1]=[C:2]([O:3]O)[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[Cl:10]>CSCN(C)C(=O)Nc1ccc(c(c1)Cl)Cl.ClCCl>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[Cl:10]|US07132092B2_0169
9.7.71|[c:2]-[N&H1&+0&D2:1]-N>>[c:2]-[N&H2&+0&D1:1]|N[NH:1][c:2]1[cH:3][c:4]([cH:5][cH:6][n:7]1)[CH:8]1[CH2:9][O:10][CH2:11][CH2:12][O:13]1>CCO.[H][H].[Ni]>[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][n:7]1)[CH:8]1[CH2:9][O:10][CH2:11][CH2:12][O:13]1|US06313122B1
9.7.71|[C:2]-[N&H1&+0&D2:1]-N>>[C:2]-[N&H2&+0&D1:1]|N[NH:1][CH2:2][C:3]1([c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH:10]=[CH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)[OH:18]>CC(=O)O.CCOC(C)=O.[H][H].[O-2].[O-2].[Pt+4]>[NH2:1][CH2:2][C:3]1([c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH:10]=[CH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)[OH:18]|US09090847B2_0104
9.7.139|[c:2]-[C&H2&+0&D2:1]-Br>>[c:2]-[C&H3&+0&D1:1]|[F:1][C:2]1([O:3][c:4]2[cH:5][cH:6][cH:7][c:8]([c:9]2[O:10]1)[CH2:11]Br)[F:12]>>[CH3:11][c:8]1[cH:7][cH:6][cH:5][c:4]2[O:3][C:2]([O:10][c:9]21)([F:1])[F:12]|US05395932A
9.7.139|[C:2]-[C&H2&+0&D2:1]-Br>>[C:2]-[C&H3&+0&D1:1]|[CH3:1][C:2](=[O:3])[O:4][CH:5]1[CH:6]([CH:7]([CH:8]2[CH2:9][C:10]1([O:11][C:12]([NH:13]2)=[O:14])[CH2:15]Br)[O:16][C:17]([CH3:18])=[O:19])[O:20][C:21]([CH3:22])=[O:23]>CCCC[SnH](CCCC)CCCC.CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccccc1>[CH3:18][C:17](=[O:19])[O:16][CH:7]1[CH:8]2[CH2:9][C:10]([O:11][C:12]([NH:13]2)=[O:14])([CH:5]([CH:6]1[O:20][C:21]([CH3:22])=[O:23])[O:4][C:2]([CH3:1])=[O:3])[CH3:15]|US20110301143A1_0701
9.7.59|[C:2]-[C&H2&+0&D2:1]-Cl>>[C:2]-[C&H3&+0&D1:1]|Cl.Cl.[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH2:8][CH2:9]Cl>Cl.CC(C)O.O=C(O[Na])O[Na]>[CH3:9][CH2:8][N:5]1[CH2:4][CH2:3][N:2]([CH2:7][CH2:6]1)[CH3:1]|US07351719B2_0619
9.7.59|[c:2]-[C&H2&+0&D2:1]-Cl>>[c:2]-[C&H3&+0&D1:1]|[NH2:1][C:2](=[O:3])[NH:4][CH:5]([C:6](=[O:7])[OH:8])[c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)[CH2:15]Cl)[OH:16]>O.[H][H].[Pd]>[CH3:15][c:13]1[cH:14][c:9]([cH:10][cH:11][c:12]1[OH:16])[CH:5]([NH:4][C:2]([NH2:1])=[O:3])[C:6](=[O:7])[OH:8]|US05789440A
9.7.86|[c:2]-[N&H0&+0&D2:1]=C=O>>[c:2]-[N&H2&+0&D1:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[N:8]1[C:9]([c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[C:16]1=[O:17])[Cl:18])=[O:19])[N:20]=C=O>Cl.C1COCCO1>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[N:8]1[C:16]([c:15]2[cH:14][cH:13][c:12]([cH:11][c:10]2[C:9]1=[O:19])[Cl:18])=[O:17])[NH2:20]|US20090203577A1_0849
9.7.148|[N:2]-[N&H0&+0&D2:1]=C-C>>[N:2]-[N&H2&+0&D1:1]|Cl.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[N:9]([N:10]=CC)[c:11]1[n:12][cH:13][n:14][c:15]2[cH:16][c:17]([cH:18][cH:19][c:20]21)[Cl:21]>Cl.CCO>[CH3:1][O:2][c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[N:9]([NH2:10])[c:11]1[n:12][cH:13][n:14][c:15]2[cH:16][c:17]([cH:18][cH:19][c:20]21)[Cl:21]|US09725426B2_0368
7.9.14|[C:2]-[S&H0&+0&D2:1]-S-C>>[C:2]-[S&H1&+0&D1:1]|[CH2:1]=[C:2]1[CH2:3][C@H:4]2[CH:5]=[N:6][c:7]3[cH:8][c:9]([c:10]([cH:11][c:12]3[C:13]([N:14]2[CH2:15]1)=[O:16])[O:17][CH3:18])[O:19][CH2:20][c:21]1[cH:22][c:23]([cH:24][c:25]([cH:26]1)[NH:27][C:28](=[O:29])[CH2:30][CH2:31][C:32]([CH3:33])([CH3:34])[S:35]SC)[CH2:36][O:37][c:38]1[cH:39][c:40]2[N:41]=[CH:42][C@@H:43]3[CH2:44][C:45]([CH2:46][N:47]3[C:48]([c:49]2[cH:50][c:51]1[O:52][CH3:53])=[O:54])=[CH2:55]>O=C(O)CCP(CCC(=O)O)CCC(=O)O.CO.Cl>[CH2:1]=[C:2]1[CH2:15][N:14]2[C:13]([c:12]3[cH:11][c:10]([c:9]([cH:8][c:7]3[N:6]=[CH:5][C@@H:4]2[CH2:3]1)[O:19][CH2:20][c:21]1[cH:22][c:23]([cH:24][c:25]([cH:26]1)[NH:27][C:28](=[O:29])[CH2:30][CH2:31][C:32]([CH3:33])([CH3:34])[SH:35])[CH2:36][O:37][c:38]1[cH:39][c:40]2[N:41]=[CH:42][C@@H:43]3[CH2:44][C:45]([CH2:46][N:47]3[C:48]([c:49]2[cH:50][c:51]1[O:52][CH3:53])=[O:54])=[CH2:55])[O:17][CH3:18])=[O:16]|US04382949A
9.7.334|[c:2]-[N&H0&+0&D3:1](-C)-C>>[c:2]-[N&H2&+0&D1:1]|C[N:1](C)[c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[cH:9][cH:10][n:11][cH:12][cH:13]1>Cl.Br.c1ccncc1>[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[cH:9][cH:10][n:11][cH:12][cH:13]1|US06583154B1
9.7.334|[C:2]-[N&H0&+0&D3:1](-C)-C>>[C:2]-[N&H2&+0&D1:1]|C[N:1](C)[CH:2]=[C:3]1[C:4]([N:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12)[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[Cl:18])=[O:19]>N.CCO>[NH2:1][CH:2]=[C:3]1[C:4]([N:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12)[c:12]1[cH:17][c:16]([cH:15][cH:14][cH:13]1)[Cl:18])=[O:19]|US04549988A
9.7.148|[O:2]-[N&H0&+0&D2:1]=C(-C)-C>>[O:2]-[N&H2&+0&D1:1]|CC(C)=[N:1][O:2][CH2:3][CH:4]([CH3:5])[O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[Cl:13]>O.O=C(O)C(Cl)(Cl)Cl>[CH3:5][CH:4]([CH2:3][O:2][NH2:1])[O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[Cl:13]|EP2029580B1_0049
6.4.1|[C:2]-[S&H0&+0&D2:1]-C(-C)=O>>[C:2]-[S&H1&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([CH2:7][CH2:8][C@H:9]1[CH2:10][CH2:11][C:12]([C@@H:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20](=[O:21])[O:22][CH2:23][CH3:24])=[O:25])[S:26]C(C)=O>CO>[CH3:24][CH2:23][O:22][C:20](=[O:21])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]1[C:12]([CH2:11][CH2:10][C@@H:9]1[CH2:8][CH2:7][CH:6]([SH:26])[CH2:5][CH2:4][CH2:3][CH2:2][CH3:1])=[O:25]|US07834041B2_0444
7.1.1|[c:2]-[N&H0&+&D3:1](-[O&-])=O>>[c:2]-[N&H2&+0&D1:1]|[CH3:1][C:2](=[O:3])[c:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[c:17]1[N+:18]([O-])=O>NN.[Ni]>[CH3:1][C:2](=[O:3])[c:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[c:17]1[NH2:18]|US07790729B2_1053
7.1.1|[N:2]-[N&H0&+&D3:1](-[O&-])=O>>[N:2]-[N&H2&+0&D1:1]|[O-][N+:1](=O)[N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>CO.[H][H].[Pd]>[NH2:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US07138425B2_0390
7.1.1|[C:2]-[N&H0&+&D3:1](-[O&-])=O>>[C:2]-[N&H2&+0&D1:1]|[CH3:1][CH2:2][C:3]([CH3:4])([CH2:5][c:6]1[cH:7][nH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21)[N+:15]([O-])=O>CCO.[H][H].[Pd]>[CH3:1][CH2:2][C:3]([CH3:4])([NH2:15])[CH2:5][c:6]1[cH:7][nH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21|US10308668B2_0414
9.7.109|[c:2]-[S&H0&+0&D4:1](-Cl)(=O)=O>>[c:2]-[S&H1&+0&D1:1]|[O:1]=[S:2]1([NH:3][CH:4]=[N:5][c:6]2[cH:7][c:8]([c:9]([cH:10][c:11]21)[S:12](=O)(=O)Cl)[C:13]([F:14])([F:15])[F:16])=[O:17]>Cl[Sn]Cl.O.O>[O:1]=[S:2]1([NH:3][CH:4]=[N:5][c:6]2[cH:7][c:8]([c:9]([cH:10][c:11]21)[SH:12])[C:13]([F:14])([F:15])[F:16])=[O:17]|EP2752928B1_0285
9.7.13|[c:2]-[N&H0&+0&D2:1]=[N&+]=[N&-]>>[c:2]-[N&H2&+0&D1:1]|[N-]=[N+]=[N:1][c:2]1[n:3][c:4]2[c:5]([n:6][cH:7][n:8]2[CH2:9][O:10][CH2:11][CH2:12][OH:13])[c:14]([n:15]1)[NH2:16]>CCO.[Pd]>[NH2:1][c:2]1[n:15][c:14]([c:5]2[n:6][cH:7][n:8]([c:4]2[n:3]1)[CH2:9][O:10][CH2:11][CH2:12][OH:13])[NH2:16]|US07642361B2_0434
9.7.13|[C:2]-[N&H0&+0&D2:1]=[N&+]=[N&-]>>[C:2]-[N&H2&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([CH2:7][CH2:8][C@H:9]1[CH2:10][CH2:11][C:12]([C@@H:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20](=[O:21])[O:22][CH2:23][CH3:24])=[O:25])[N:26]=[N+]=[N-]>COc1cc2c(cc1OC)[C@@]13CCN4CC5=CCO[C@H]6CC(N2[C@H]1[C@H]6[C@H]5C[C@H]43)=O.[Pd]>[CH3:24][CH2:23][O:22][C:20](=[O:21])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]1[C:12]([CH2:11][CH2:10][C@@H:9]1[CH2:8][CH2:7][CH:6]([NH2:26])[CH2:5][CH2:4][CH2:3][CH2:2][CH3:1])=[O:25]|US09856241B2_1355
6.3.7|[C&H3&D1:2]-[O&H0&+0&D2:1]-C>>[C&H3&D1:2]-[O&H1&+0&D1:1]|[CH3:1][O:2]C>>[CH3:1][OH:2]|
9.7.61|[C:2]-[O&H0&+0&D2:1]-c1:c:c:c:c:c:1>>[C:2]-[O&H1&+0&D1:1]|[CH3:1][CH2:2][C@H:3]([CH3:4])[C@H:5]([NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[NH:19][C@H:20]([C:21](=[O:22])[NH:23][C@H:24]([C:25](=[O:26])[NH:27][C@@H:28]([CH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[C:41](=[O:42])[O:43]c1ccccc1)[C@@H:44]([CH3:45])[O:46][C:47]([CH3:48])([CH3:49])[CH3:50])[C@@H:51]([CH3:52])[O:53][C:54]([CH3:55])([CH3:56])[CH3:57]>CC(C)=O.CC(=O)O.CO.OO.O.Cl>[CH3:1][CH2:2][C@H:3]([CH3:4])[C@H:5]([NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[NH:19][C@H:20]([C:21](=[O:22])[NH:23][C@H:24]([C:25](=[O:26])[NH:27][C@@H:28]([CH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[C:41](=[O:42])[OH:43])[C@@H:44]([CH3:45])[O:46][C:47]([CH3:48])([CH3:49])[CH3:50])[C@@H:51]([CH3:52])[O:53][C:54]([CH3:55])([CH3:56])[CH3:57]|EP2911656B1_0101
9.7.326|[c:2]-[O&H0&+0&D2:1]-c1:c:c:c:c:c:1>>[c:2]-[O&H1&+0&D1:1]|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[C:9]([c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]12)[O:16]c1ccccc1)=[O:17]>[Na+].[Na+].[O-]S(=O)(=O)C1C2=C(C=CC1(Oc1ccccc1)S([O-])(=O)=O)C(c1ccccc1C2=O)=O.O=C(O)c1ccccc1C(=O)c1ccc(cc1)Oc1ccccc1>[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[C:9]([c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]12)[OH:16])=[O:17]|US10065930B2_0084
9.7.147|[n:3]:[c&H0&+0&D3:2](:[s:1])-N>>[n:3]:[c&H1&+0&D2:2]:[s:1]|N[c:1]1[n:2][c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[s:9]1>[N-]=C=O>[cH:1]1[n:2][c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[s:9]1|US20200270274A1_0223
9.7.147|[c:3]:[c&H0&+0&D3:2](:[n:1])-N>>[c:3]:[c&H1&+0&D2:2]:[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]([CH2:6][CH2:7][CH2:8][CH3:9])[c:10]1[cH:11][cH:12][n:13][c:14]([cH:15]1)N>>[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]([CH2:6][CH2:7][CH2:8][CH3:9])[c:10]1[cH:15][cH:14][n:13][cH:12][cH:11]1|US08697873B2_0807
9.7.334|[S:3]-[N&H0&+0&D3:2](-[c:1])-C>>[S:3]-[N&H1&+0&D2:2]-[c:1]|[CH2:1]=[CH:2][S:3](=[O:4])(=[O:5])[N:6](C)[c:7]1[cH:8][cH:9][cH:10][c:11]([c:12]1[CH3:13])[B:14]1[O:15][C:16]([C:17]([O:18]1)([CH3:19])[CH3:20])([CH3:21])[CH3:22]>CC1(OB(OC1(C)C)c1cccc(c1C)N)C>[CH2:1]=[CH:2][S:3](=[O:4])(=[O:5])[NH:6][c:7]1[cH:8][cH:9][cH:10][c:11]([c:12]1[CH3:13])[B:14]1[O:15][C:16]([C:17]([O:18]1)([CH3:19])[CH3:20])([CH3:21])[CH3:22]|US07622583B2_0760
9.7.60|[C:3]-[C&H1&+0&D3:2](-[N:1])-O>>[C:3]-[C&H2&+0&D2:2]-[N:1]|[CH3:1][C:2]1([CH2:3][NH:4][C:5]([NH:6][CH:7]1O)=[O:8])[CH3:9]>>[CH3:1][C:2]1([CH2:3][NH:4][C:5]([NH:6][CH2:7]1)=[O:8])[CH3:9]|US09487510B2_1177
9.7.334|[C:3]-[N&H0&+0&D3:2](-[O:1])-C>>[C:3]-[N&H1&+0&D2:2]-[O:1]|[CH3:1][c:2]1[n:3][c:4]([c:5]([n:6]1[CH2:7][c:8]1[s:9][c:10]2[c:11]([c:12]([n:13]([c:14]([n:15]2[CH2:16][CH:17]([CH3:18])[CH3:19])=[O:20])[CH3:21])=[O:22])[c:23]1[C:24](=[O:25])[N:26](C)[O:27][CH3:28])[Cl:29])[Cl:30]>Cl.CON>[CH3:18][CH:17]([CH3:19])[CH2:16][n:15]1[c:10]2[s:9][c:8]([c:23]([c:11]2[c:12]([n:13]([c:14]1=[O:20])[CH3:21])=[O:22])[C:24](=[O:25])[NH:26][O:27][CH3:28])[CH2:7][n:6]1[c:2]([n:3][c:4]([c:5]1[Cl:29])[Cl:30])[CH3:1]|US09562012B2_0592
9.7.147|[C:3]-[N&H0&+0&D3:2](-[C:1])-N>>[C:3]-[N&H1&+0&D2:2]-[C:1]|N[N:1]([CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[C:9](=[O:10])[CH2:11][O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[N+:19]([O-:20])=[O:21]>O.Cl.CCOC(C)=O.O=NO[Na]>[O-:20][N+:19](=[O:21])[c:16]1[cH:17][cH:18][c:13]([cH:14][cH:15]1)[O:12][CH2:11][C:9](=[O:10])[NH:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|US05654318A
9.7.141|[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c:3]:[c&H1&+0&D2:2]:[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[c:18]1I)=[O:19]>c1ccncc1>[O-:1][N+:2](=[O:3])[c:4]1[cH:18][c:17]2[cH:16][cH:15][cH:14][cH:13][c:12]2[c:11]([c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]21)=[O:19]|US06458337B1
9.7.60|[C:3]-[C&H1&+0&D3:2](-[c:1])-O>>[C:3]-[C&H2&+0&D2:2]-[c:1]|[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][CH:6](O)[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[Cl:19]>CC(=O)O.O=[Cl](=O)(=O)O.[H][H].[Pd]>[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[Cl:19]|US20190367495A1_0585
9.7.140|[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[c:3]:[c&H1&+0&D2:2]:[c:1]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][C:6]1([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[CH:13]([CH2:14][c:15]2[cH:16][c:17]([cH:18][cH:19][c:20]21)F)[CH2:21][CH2:22][N:23]([CH3:24])[CH3:25])[OH:26]>>[CH3:24][N:23]([CH3:25])[CH2:22][CH2:21][CH:13]1[CH2:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[C:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21)([OH:26])[CH2:5][Si:2]([CH3:1])([CH3:3])[CH3:4]|US20120065210A1_0205
7.2.1|[C:3]-[C&H0&+0&D3:2](-[N:1])=O>>[C:3]-[C&H2&+0&D2:2]-[N:1]|[CH2:1]=[CH:2][CH2:3][O:4][CH2:5][CH:6]1[CH2:7][N:8]([C:9]([CH2:10][O:11]1)=O)[CH2:12][CH2:13][CH3:14]>O.CCOCC.[Li][AlH4]>[CH2:1]=[CH:2][CH2:3][O:4][CH2:5][CH:6]1[CH2:7][N:8]([CH2:9][CH2:10][O:11]1)[CH2:12][CH2:13][CH3:14]|US08580962B2_0550
9.7.140|[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[c:3]:[c&H1&+0&D2:2]:[n:1]|[NH2:1][c:2]1[n:3][c:4]([cH:5][cH:6][c:7]1[C:8](=[O:9])[OH:10])F>O=C1C(Nc2ccccc12)=O>[NH2:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[OH:10]|US20200016136A1_0308
9.7.147|[n:3]:[c&H0&+0&D3:2](:[n:1])-N>>[n:3]:[c&H1&+0&D2:2]:[n:1]|N[c:1]1[n:2][c:3]2-[c:4]3[cH:5][cH:6][cH:7][cH:8][c:9]3[CH2:10][n:11]2[n:12]1>O.[Na+].CC(=O)O.NC=O.NN1Cc2ccccc2C1=O.[O-]N=O.O=S(=O)(O)O.O=[PH2]O.C1CCNCC1>[cH:1]1[n:2][c:3]2-[c:4]3[cH:5][cH:6][cH:7][cH:8][c:9]3[CH2:10][n:11]2[n:12]1|US20130345242A1_0558
9.7.147|[c:3]:[c&H0&+0&D3:2](:[s:1])-N>>[c:3]:[c&H1&+0&D2:2]:[s:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[s:7][c:8]([c:9]([c:10]1[CH3:11])[C:12]#[N:13])N>CC#N.CN(C)C=O.CC(C)(C)ON=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[s:7][cH:8][c:9]([c:10]1[CH3:11])[C:12]#[N:13]|US08362008B2_0966
9.7.147|[c:3]:[c&H0&+0&D3:2](:[c:1])-N>>[c:3]:[c&H1&+0&D2:2]:[c:1]|N[c:1]1[cH:2][cH:3][cH:4][c:5]([c:6]1[NH2:7])[S:8](=[O:9])(=[O:10])[OH:11]>Nc1cc(cc2cc(cc(c12)O)S(=O)(=O)O)S(=O)(=O)O.Clc1nc(nc(n1)Cl)Cl.Nc1cccc(c1)N>[NH2:7][c:6]1[cH:1][cH:2][cH:3][cH:4][c:5]1[S:8](=[O:9])(=[O:10])[OH:11]|US06462074B1
9.7.147|[C:3]-[C&H1&+0&D3:2](-[C:1])-N>>[C:3]-[C&H2&+0&D2:2]-[C:1]|N[CH:1]([CH2:2][CH:3]([F:4])[N:5]1[CH2:6][CH2:7][N:8]([CH2:9][CH2:10]1)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>O.Cl.O=NO[Na].O=[PH2]O.O[Na]>[O:18]=[C:17]([CH2:1][CH2:2][CH:3]([F:4])[N:5]1[CH2:6][CH2:7][N:8]([CH2:9][CH2:10]1)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|US06784197B2
9.7.141|[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[c:3]:[c&H1&+0&D2:2]:[n:1]|[CH3:1][c:2]1[n:3][c:4]([c:5]([n:6]1-[c:7]1[cH:8][c:9]2[cH:10][cH:11][c:12]([nH:13][c:14]2[c:15]([cH:16]1)[CH3:17])=[O:18])I)[I:19]>[NH4+].[Cl-].CCCCCC.CCCC[Li].O=C(O[Na])O[Na].C1CCOC1>[CH3:1][c:2]1[n:3][c:4]([cH:5][n:6]1-[c:7]1[cH:8][c:9]2[cH:10][cH:11][c:12]([nH:13][c:14]2[c:15]([cH:16]1)[CH3:17])=[O:18])[I:19]|EP2261212A2_0133
7.9.4|[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[c:3]-[C&H2&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[C:8](=O)[c:9]1[c:10]([cH:11][cH:12][cH:13][c:14]1[F:15])[F:16])[Cl:17]>OCCOCCO.O[K]>[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[CH2:8][c:9]1[c:10]([cH:11][cH:12][cH:13][c:14]1[F:15])[F:16])[Cl:17]|US06974877B2_0102
7.9.4|[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH2:7][CH2:8][C:9]([c:10]2[cH:11][c:12]1[O:13][CH3:14])=O>>[CH3:14][O:13][c:12]1[cH:11][c:10]2[CH2:9][CH2:8][CH2:7][CH2:6][c:5]2[cH:4][c:3]1[O:2][CH3:1]|US20200276320A1_0685
9.7.60|[c:3]:[c&H0&+0&D3:2](:[n:1])-O>>[c:3]:[c&H1&+0&D2:2]:[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([n:10][c:11]1O)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>[Na+].Cl.CCO.CCOC(=O)C(=COCC)C(=O)OCC.CCCCCc1ccc(cc1)C(=N)N.CC[O-].O=P(Cl)(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:11][n:10][c:9]([n:8][cH:7]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]|US04851413A
9.7.334|[C:3]-[N&H0&+0&D3:2](-[c:1])-C>>[C:3]-[N&H1&+0&D2:2]-[c:1]|C[N:1]1[C:2]([C:3]([N:4]=[C:5]([c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]21)[N+:12]([O-:13])=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[Cl:21])([CH3:22])[CH3:23])=[O:24]>CC1(N=C(c2cc(ccc2N(C1=O)C)[N+]([O-])=O)c1ccccc1F)C.CCOC(C)=O.ClCCl>[CH3:22][C:3]1([N:4]=[C:5]([c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[NH:1][C:2]1=[O:24])[N+:12]([O-:13])=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[Cl:21])[CH3:23]|US06762180B1
9.7.334|[c:3]:[n&H0&+0&D3:2](:[c:1])-C>>[c:3]:[n&H1&+0&D2:2]:[c:1]|C[n:1]1[cH:2][c:3]([cH:4][c:5]([c:6]1=[O:7])[Cl:8])[Cl:9]>Nc1ccccn1.O=c1cccc[nH]1.O=NO[K].O=S(=O)(O)O>[O:7]=[c:6]1[nH:1][cH:2][c:3]([cH:4][c:5]1[Cl:8])[Cl:9]|US06924276B2_0516
9.7.334|[n:3]:[n&H0&+0&D3:2](:[n:1])-C>>[n:3]:[n&H1&+0&D2:2]:[n:1]|C[n:1]1[n:2][c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[n:9]1)[NH:10][N:11]=[C:12]1[C:13](=[N:14][N:15]=[C:16]1[NH2:17])[NH2:18]>O.Cn1nc2ccc(cc2n1)N.Cn1nc2ccc(cc2n1)[N+]([O-])=O.N#CCC#N.NN>[NH2:17][C:16]1=[N:15][N:14]=[C:13]([C:12]1=[N:11][NH:10][c:5]1[cH:6][cH:7][c:8]2[n:9][nH:1][n:2][c:3]2[cH:4]1)[NH2:18]|EP0054416B1_0039
9.7.60|[C:3]-[C&H1&+0&D3:2](-[C:1])-O>>[C:3]-[C&H2&+0&D2:2]-[C:1]|[CH2:1]=[CH:2][C:3](=[O:4])[O:5][CH2:6][CH:7](O)[CH2:8][OH:9]>>[CH2:1]=[CH:2][C:3](=[O:4])[O:5][CH2:6][CH2:7][CH2:8][OH:9]|US20190314300A1_0055
7.9.22|[C:3]-[S&H0&+0&D3:2](-[c:1])=O>>[C:3]-[S&H0&+0&D2:2]-[c:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][c:7]([c:8]2[c:9]1[NH:10][CH2:11][CH2:12][S:13]2=O)[Cl:14]>O.O.CO.CCOC(C)=O.Cl[Sn]Cl>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][c:7]([c:8]2[S:13][CH2:12][CH2:11][NH:10][c:9]12)[Cl:14]|EP1105387B1_0052
9.7.60|[c:3]-[C&H1&+0&D3:2](-[c:1])-O>>[c:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH2:3][OH:4])[c:5]1[cH:6][cH:7][c:8]2[O:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH:16]([c:17]2[cH:18]1)O>I.CC(=O)O>[CH3:1][CH:2]([CH2:3][OH:4])[c:5]1[cH:6][cH:7][c:8]2[O:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][c:17]2[cH:18]1|US20090076046A1_1065
7.2.1|[N:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][N:2]1[C:3]([CH:4]2[CH2:5][CH2:6][CH2:7][N:8]2[C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)=O)=[O:16]>CO.Cn1c2ccccc2c(oc1=O)=O.O=C(O)[C@H]1CCCN1.C1CCOC1.B>[CH3:1][N:2]1[C:3]([CH:4]2[CH2:5][CH2:6][CH2:7][N:8]2[CH2:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)=[O:16]|US04775671A
9.7.334|[c:3]-[N&H0&+0&D3:2](-[c:1])-C>>[c:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N:12](C)[c:13]1[cH:14][cH:15][c:16]2[C:17](=[CH:18][CH2:19][C:20]([c:21]2[cH:22]1)([CH3:23])[CH3:24])[CH3:25]>CCO.CC1=CCC(c2cc(ccc12)N(C)c1ccc(cc1)C(=O)O)(C)C.[OH-].[K+]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[NH:12][c:13]1[cH:14][cH:15][c:16]2[C:17](=[CH:18][CH2:19][C:20]([c:21]2[cH:22]1)([CH3:23])[CH3:24])[CH3:25]|US09907804B2_0697
9.7.140|[C:3]-[C&H1&+0&D3:2](-[C:1])-F>>[C:3]-[C&H2&+0&D2:2]-[C:1]|F[CH:1]([CH:2]([F:3])[C:4]([F:5])([F:6])[F:7])[C:8]([F:9])([F:10])[C:11]([F:12])([F:13])[F:14]>O=C(O[K])O[K]>[F:5][C:4]([F:6])([F:7])[CH:2]([F:3])[CH2:1][C:8]([F:9])([F:10])[C:11]([F:12])([F:13])[F:14]|US20090078918A1_0030
9.7.60|[O:3]-[C&H1&+0&D3:2](-[c:1])-O>>[O:3]-[C&H2&+0&D2:2]-[c:1]|O[CH:1]1[O:2][CH2:3][c:4]2[cH:5][c:6]([cH:7][cH:8][c:9]21)[Br:10]>CC[SiH](CC)CC.O=C(O)C(F)(F)F.ClCCl>[Br:10][c:6]1[cH:7][cH:8][c:9]2[CH2:1][O:2][CH2:3][c:4]2[cH:5]1|US20120088750A1_0508
7.9.20|[c:3]-[P&H1&+0&D3:2](-[c:1])=O>>[c:3]-[P&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[PH:9](=O)[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[O:16][CH3:17]>Cc1ccccc1.O=[PH3].O[Na].Cl[SiH](Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[PH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[O:16][CH3:17]|EP1452537A1_0160
7.9.22|[C:3]-[S&H0&+0&D3:2](-[C:1])=O>>[C:3]-[S&H0&+0&D2:2]-[C:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[c:8]1[cH:9][cH:10][cH:11][cH:12]2)[CH2:13][C:14]1=[C:15]([N:16]2[C:17]([C@H:18]([C@H:19]2[S:20]([CH:21]1[NH2:22])=O)[C:23](=[O:24])[CH2:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)=[O:32])[C:33](=[O:34])[O:35][CH2:36][C:37]([Cl:38])([Cl:39])[Cl:40]>O=S1(CCCC1)=O.[O-]S(=O)S([O-])=O.CC(=O)Cl.[O-]C(=O)O.CC#N.[Na+].[Na+].[Na+]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[c:8]1[cH:9][cH:10][cH:11][cH:12]2)[CH2:13][C:14]1=[C:15]([N:16]2[C:17]([C@H:18]([C@H:19]2[S:20][CH:21]1[NH2:22])[C:23](=[O:24])[CH2:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)=[O:32])[C:33](=[O:34])[O:35][CH2:36][C:37]([Cl:38])([Cl:39])[Cl:40]|US20070060558A1_0439
9.7.147|[C:3]-[C&H1&+0&D3:2](-[c:1])-N>>[C:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3]1([C:4]([N:5]2[C@H:6]([C:7]([S:8][C@@H:9]21)([CH3:10])[CH3:11])[C:12](=[O:13])[OH:14])=[O:15])[NH:16][C:17](=[O:18])[CH:19](N)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>>[CH3:1][O:2][C:3]1([C:4]([N:5]2[C@H:6]([C:7]([S:8][C@@H:9]21)([CH3:10])[CH3:11])[C:12](=[O:13])[OH:14])=[O:15])[NH:16][C:17](=[O:18])[CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US04179557A
9.7.334|[C:3]-[N&H0&+0&D3:2](-[C:1])-C>>[C:3]-[N&H1&+0&D2:2]-[C:1]|C[N:1]1[CH2:2][CH2:3][CH:4]([CH2:5][CH2:6]1)[c:7]1[cH:8][s:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21>Cc1ccccc1.CCOC(=O)Cl>[cH:13]1[cH:12][cH:11][c:10]2[s:9][cH:8][c:7]([c:15]2[cH:14]1)[CH:4]1[CH2:3][CH2:2][NH:1][CH2:6][CH2:5]1|US07235538B2_0522
9.7.141|[C:3]-[C&H1&+0&D3:2](-[C:1])-I>>[C:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][NH:2][C:3](=[O:4])[NH:5][C:6]1([c:7]2[cH:8][cH:9][s:10][c:11]2[CH2:12][CH2:13][CH:14]1I)[CH3:15]>CO.O=[Mg].[H][H].[Pd]>[CH3:1][NH:2][C:3](=[O:4])[NH:5][C:6]1([CH2:14][CH2:13][CH2:12][c:11]2[s:10][cH:9][cH:8][c:7]21)[CH3:15]|US20080004290A1_0222
9.7.60|[N:3]-[C&H1&+0&D3:2](-[c:1])-O>>[N:3]-[C&H2&+0&D2:2]-[c:1]|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[CH:9]([N:10]1[CH2:11][CH2:12][CH2:13][N:14]1[CH2:15][CH:16]=[C:17]([CH2:18][CH2:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)O>CC(=O)O.[Zn]>[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[CH2:9][N:10]1[CH2:11][CH2:12][CH2:13][N:14]1[CH2:15][CH:16]=[C:17]([CH2:18][CH2:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|EP1751163B1_0266
9.7.147|[c:3]:[n&H0&+0&D3:2](:[c:1])-N>>[c:3]:[n&H1&+0&D2:2]:[c:1]|N[n:1]1[c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]21>O=C(Cl)c1cc(cc(c1)C(=O)Cl)C(=O)Cl.c1ccncc1.O>[cH:4]1[cH:5][cH:6][c:7]2[c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[nH:1][c:2]2[cH:3]1|US20050075342A1_0805
9.7.60|[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[c:3]:[c&H1&+0&D2:2]:[c:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[N:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)O>[Na+].C[O-].O=C(c1ccccc1)N(c1ccccc1)c1ccc(cc1)OCCN1CCCCC1.ClCCN1CCCCC1>[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[N:9]([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US10329270B2_0604
9.7.60|[C:3]-[C&H1&+0&D3:2](-[O:1])-O>>[C:3]-[C&H2&+0&D2:2]-[O:1]|O[CH:1]1[CH2:2][c:3]2[cH:4][c:5]([c:6]([cH:7][c:8]2[O:9]1)[N:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1)[Cl:16]>CCO.[O-2].[Pt+2]>[Cl:16][c:5]1[cH:4][c:3]2[CH2:2][CH2:1][O:9][c:8]2[cH:7][c:6]1[N:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1|US10662171B2_0652
9.7.334|[c:3]:[n&H0&+0&D3:2](:[n:1])-C>>[c:3]:[n&H1&+0&D2:2]:[n:1]|C[n:1]1[cH:2][n:3][c:4]([n:5]1)[CH2:6][N:7]([CH2:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[S:16](=[O:17])(=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>>[O:17]=[S:16](=[O:18])([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[N:7]([CH2:8][CH2:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1)[CH2:6][c:4]1[n:3][cH:2][nH:1][n:5]1|EP2885285B1_0237
7.9.4|[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][C:2](=[O:3])[C@H:4]1[CH2:5][CH2:6][C@H:7]2[C@@H:8]3[CH2:9][CH2:10][C@H:11]4[CH2:12][C@:13]([CH2:14][CH2:15][C@@:16]4([C@H:17]3[C:18]([CH2:19][C@:20]12[CH3:21])=O)[CH3:22])([CH3:23])[OH:24]>>[CH3:1][C:2](=[O:3])[C@H:4]1[CH2:5][CH2:6][C@H:7]2[C@@H:8]3[CH2:9][CH2:10][C@H:11]4[CH2:12][C@:13]([CH2:14][CH2:15][C@@:16]4([C@H:17]3[CH2:18][CH2:19][C@:20]12[CH3:21])[CH3:22])([CH3:23])[OH:24]|US08188002B2_0138
6.3.1|[n:2]-[O&H0&+0&D2:1]-C-c1:c:c:c:c:c:1>>[n:2]-[O&H1&+0&D1:1]|[CH3:1][O:2][c:3]1[n:4][c:5]([n:6][c:7]2[c:8]1[n:9][cH:10][n:11]2[O:12]Cc1ccccc1)[NH2:13]>CCO.C1COCCO1.[Pd]>[CH3:1][O:2][c:3]1[n:4][c:5]([n:6][c:7]2[c:8]1[n:9][cH:10][n:11]2[OH:12])[NH2:13]|US20100056516A1_0404
9.7.139|[c:3]:[c&H0&+0&D3:2](:[o:1])-Br>>[c:3]:[c&H1&+0&D2:2]:[o:1]|[CH3:1][CH2:2][CH:3]([NH:4][CH2:5][CH2:6][N:7]([CH3:8])[CH3:9])[c:10]1[n:11][c:12]2[o:13][c:14]([cH:15][c:16]2[c:17]([n:18]1[CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)=[O:26])Br>CCO.[Pd]>[CH3:1][CH2:2][CH:3]([NH:4][CH2:5][CH2:6][N:7]([CH3:8])[CH3:9])[c:10]1[n:11][c:12]2[o:13][cH:14][cH:15][c:16]2[c:17]([n:18]1[CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)=[O:26]|US20150031668A1_1200
9.7.59|[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[n:3]:[c&H1&+0&D2:2]:[n:1]|[CH3:1][CH:2]([CH3:3])[NH:4][c:5]1[n:6][c:7]([n:8][c:9]2[cH:10][s:11][cH:12][c:13]21)Cl>CCO.CC(=O)O.[Zn]>[CH3:1][CH:2]([CH3:3])[NH:4][c:5]1[n:6][cH:7][n:8][c:9]2[cH:10][s:11][cH:12][c:13]12|US07129239B2_0360
9.7.139|[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[c:3]:[c&H1&+0&D2:2]:[s:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[s:8][c:9]([c:10]2[Br:11])Br>O.CCOCC.CCCC[Li]>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:9][s:8][c:6]2[cH:7]1)[Br:11]|US07879888B2_0284
6.1.14|[c:2]-[N&H0&+0&D2:1]=C-c1:c:c:c:c:c:1>>[c:2]-[N&H2&+0&D1:1]|[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[C:11](=[O:12])[O:13][CH3:14])[N:15]=Cc1ccccc1>O>[CH3:14][O:13][C:11](=[O:12])[c:10]1[cH:9][c:8]([cH:7][cH:6][c:5]1[O:4][C:2]([CH3:1])=[O:3])[NH2:15]|US06310070B1
6.1.14|[N:2]-[N&H0&+0&D2:1]=C-c1:c:c:c:c:c:1>>[N:2]-[N&H2&+0&D1:1]|[ClH:1].NO.[O:2]=[c:3]1[s:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[n:11]1[CH2:12][C:13](=[O:14])[N:15]1[CH2:16][CH2:17][N:18]([CH2:19][CH2:20]1)[N:21]=Cc1ccccc1)[Cl:22]>Cl.CC#N>[ClH:1].[NH2:21][N:18]1[CH2:19][CH2:20][N:15]([CH2:16][CH2:17]1)[C:13](=[O:14])[CH2:12][n:11]1[c:3]([s:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[Cl:22])=[O:2]|US20070238700A1_0385
9.7.59|[c:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[c:3]:[c&H1&+0&D2:2]:[s:1]|[O-:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([s:7][c:8]1[S:9](=[O:10])(=[O:11])[OH:12])Cl.[OH-].[K+].[K+:13]>O>[O-:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][s:7][c:8]1[S:9](=[O:10])(=[O:11])[OH:12].[K+:13]|EP1751138B1_0150
9.7.59|[C:3]-[C&H1&+0&D3:2](-[C:1])-Cl>>[C:3]-[C&H2&+0&D2:2]-[C:1]|[N:1]#[C:2][CH:3](Cl)[CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=[O:12])[OH:13]>CC(=O)O.[Zn]>[N:1]#[C:2][CH2:3][CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=[O:12])[OH:13]|US09522888B2_0485
9.7.59|[c:3]-[P&H0&+0&D3:2](-[c:1])-Cl>>[c:3]-[P&H1&+0&D2:2]-[c:1]|Cl[P:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>O>[cH:11]1[cH:10][cH:9][c:8]([cH:13][cH:12]1)[PH:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1|US20080188633A1_0180
9.7.59|[c:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[c:3]-[C&H2&+0&D2:2]-[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH:10](Cl)[c:11]1[cH:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[o:19]1>[Na+].CCCCCC.COCCOCCOC.O[Na].[BH4-]>[O-:1][N+:2](=[O:3])[c:4]1[cH:9][cH:8][c:7]([cH:6][cH:5]1)[CH2:10][c:11]1[cH:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[o:19]1|US20200399258A1_0463
9.7.59|[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[n:3]:[c&H1&+0&D2:2]:[s:1]|[CH3:1][C:2]([OH:3])([CH2:4][c:5]1[cH:6][n:7][c:8]([s:9]1)Cl)[c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[Cl:16])[Cl:17]>[NH4+].CC(=O)O.[OH-].[Zn]>[CH3:1][C:2]([OH:3])([CH2:4][c:5]1[cH:6][n:7][cH:8][s:9]1)[c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[Cl:16])[Cl:17]|US07259163B2_0737
9.7.59|[C:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[C:3]-[C&H2&+0&D2:2]-[c:1]|[NH2:1][CH2:2][CH2:3][O:4][C:5]12[NH:6][CH:7]([c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]32)[CH:14]([c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21)Cl>O.CCO.CCOCC.O[Na].[Li][AlH4]>[NH2:1][CH2:2][CH2:3][O:4][C:5]12[NH:6][CH:7]([CH2:14][c:15]3[cH:16][cH:17][cH:18][cH:19][c:20]32)[c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]21|US20040186160A1_0288
9.7.59|[C:3]-[C&H0&+0&D3:2](=[C:1])-Cl>>[C:3]-[C&H1&+0&D2:2]=[C:1]|[CH3:1][C@@H:2]1[CH2:3][C@H:4]2[C@@H:5]3[CH2:6][C@@H:7]([C:8]4=[CH:9][C:10]([C:11](=[CH:12][C@@:13]4([C@H:14]3[CH2:15][CH2:16][C@@:17]2([C@H:18]1[C:19](=[O:20])[C:21](=[O:22])[OH:23])[CH3:24])[CH3:25])Cl)=[O:26])[F:27]>>[CH3:1][C@@H:2]1[CH2:3][C@H:4]2[C@@H:5]3[CH2:6][C@@H:7]([C:8]4=[CH:9][C:10]([CH:11]=[CH:12][C@@:13]4([C@H:14]3[CH2:15][CH2:16][C@@:17]2([C@H:18]1[C:19](=[O:20])[C:21](=[O:22])[OH:23])[CH3:24])[CH3:25])=[O:26])[F:27]|US20160002530A1_0013
9.7.139|[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[c:3]:[c&H1&+0&D2:2]:[n:1]|[CH3:1][CH:2]([CH3:3])[NH:4][CH2:5][CH:6]([OH:7])[CH2:8][O:9][c:10]1[n:11][cH:12][c:13]([n:14][c:15]1[N:16]1[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1)Br>CO.[H][H].[Pd]>[CH3:1][CH:2]([CH3:3])[NH:4][CH2:5][CH:6]([OH:7])[CH2:8][O:9][c:10]1[n:11][cH:12][cH:13][n:14][c:15]1[N:16]1[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1|EP2687518A1_0134
9.7.139|[C:3]-[C&H1&+0&D3:2](-[C:1])-Br>>[C:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7](Br)[C:8](=[O:9])[O:10][CH2:11][CH3:12]>CCO.Oc1ccc(cc1)C1=CCCCCCC1.[Na]>[CH3:12][CH2:11][O:10][C:8](=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH3:1]|US10654867B2_0380
9.7.139|[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[n:3]:[c&H1&+0&D2:2]:[s:1]|[O:1]=[C:2]([NH:3][c:4]1[cH:5][s:6][c:7]([n:8]1)Br)[C:9]([F:10])([F:11])[F:12]>CC([O-])=O.CCO.O.O.O.[Na+].[Pd]>[O:1]=[C:2]([NH:3][c:4]1[cH:5][s:6][cH:7][n:8]1)[C:9]([F:10])([F:11])[F:12]|US08551984B2_1960
9.7.139|[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[n:3]:[c&H1&+0&D2:2]:[n:1]|[NH2:1][c:2]1[n:3][cH:4][n:5][c:6]2[c:7]1[n:8][c:9]([n:10]2[C@@H:11]1[O:12][C@@H:13]2[CH2:14][O:15][P:16]([O:17][C@H:18]2[C@H:19]1[OH:20])(=[O:21])[OH:22])Br>CN(C)C=O.Cl[Ca]Cl>[NH2:1][c:2]1[n:3][cH:4][n:5][c:6]2[c:7]1[n:8][cH:9][n:10]2[C@@H:11]1[O:12][C@@H:13]2[CH2:14][O:15][P:16]([O:17][C@H:18]2[C@H:19]1[OH:20])(=[O:21])[OH:22]|US09969736B2_0612
9.7.139|[C:3]-[C&H1&+0&D3:2](-[c:1])-Br>>[C:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[S:11][c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[CH2:18][CH:19]2Br>[Na+].O=S1(CCCC1)=O.[BH4-]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[CH2:19][CH2:18][c:17]3[cH:16][cH:15][cH:14][cH:13][c:12]3[S:11][c:9]2[cH:10]1|EP0150026A2_0059
9.7.59|[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:3]:[c&H1&+0&D2:2]:[n:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH2:11][c:12]1[c:13]([n:14][c:15]([n:16][c:17]1Cl)[NH2:18])[NH2:19]>Cl.COc1cc(ccc1OC)Cc1c(nc(nc1O)N)N>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH2:11][c:12]1[cH:17][n:16][c:15]([n:14][c:13]1[NH2:19])[NH2:18]|US07723336B2_0368
9.7.139|[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[c:3]:[c&H1&+0&D2:2]:[c:1]|[O:1]=[P:2]([Cl:3])([Cl:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1Br>Cc1cccc(c1C)P(=S)(Cl)Cl.Cc1cccc(c1C)P(=O)(Cl)Cl.Cc1ccccc1P(=S)(Cl)Cl.Cc1ccccc1P(=O)(Cl)Cl.O=P(Cl)(Cl)c1ccccc1Cl.O=P(Br)(Br)c1ccccc1.S=P(Cl)(Cl)c1ccccc1Br.S=P(Cl)(Cl)c1ccccc1Cl.S=P(Cl)(Cl)c1ccccc1.S=P(Br)(Br)c1ccccc1>[O:1]=[P:2]([Cl:3])([Cl:4])[c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1|US09126970B2_0306
9.7.334|[C:3]-[N&H0&+0&D3:2](-[S:1])-C-O-C>>[C:3]-[N&H1&+0&D2:2]-[S:1]|COC[N:1]([C@H:2]([CH3:3])[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[O:10][CH2:11][CH:12]1[CH2:13][CH2:14]1)[S:15](=[O:16])(=[O:17])[CH2:18][CH2:19]/[CH:20]=[CH:21]/[CH2:22][CH:23]1[CH2:24][CH2:25][C:26]([NH:27][C:28]1=[O:29])=[O:30]>O>[CH3:3][C@@H:2]([NH:1][S:15](=[O:16])(=[O:17])[CH2:18][CH2:19]/[CH:20]=[CH:21]/[CH2:22][CH:23]1[CH2:24][CH2:25][C:26]([NH:27][C:28]1=[O:29])=[O:30])[c:4]1[cH:9][c:8]([cH:7][cH:6][cH:5]1)[O:10][CH2:11][CH:12]1[CH2:13][CH2:14]1|US08101595B2_0279
7.9.23|[C:3]-[S&H0&+0&D4:2](-[c:1])(=O)=O>>[C:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][S:7](=O)(=O)[c:8]1[n:9][n:10][c:11]([s:12]1)[NH:13][C:14](=[O:15])[NH:16][c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[Cl:23])[Cl:24]>CC(=O)O.OO>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][S:7][c:8]1[n:9][n:10][c:11]([s:12]1)[NH:13][C:14](=[O:15])[NH:16][c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[Cl:23])[Cl:24]|EP3294711B1_0099
9.7.334|[C:3]-[N&H0&+0&D3:2](-[N:1])-C-C=C>>[C:3]-[N&H1&+0&D2:2]-[N:1]|C=CC[N:1]1[NH:2][C:3](=[C:4]2[C:5]1=[N:6][c:7]1[cH:8][c:9]([c:10]([cH:11][c:12]1[C:13](=[N:14]2)[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[Cl:21])[CH3:22])[CH3:23])[CH3:24]>c1ccc(cc1)P(CCCP(c1ccccc1)c1ccccc1)c1ccccc1.CC(C)C[AlH]CC(C)C.Cc1ccccc1.C1CCOC1.Cl[Ni]Cl>[CH3:24][C:3]1[NH:2][NH:1][C:5]2[C:4]=1[N:14]=[C:13]([c:12]1[cH:11][c:10]([c:9]([cH:8][c:7]1[N:6]=2)[CH3:23])[CH3:22])[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[Cl:21]|EP1802625B1_0284
7.9.23|[c:3]-[S&H0&+0&D4:2](-[c:1])(=O)=O>>[c:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][c:9]([cH:10][cH:11][c:12]1[NH:13][C:14](=[N:15][C:16](=[O:17])[O:18][CH3:19])[NH:20][C:21](=[O:22])[O:23][CH3:24])[S:25](=O)(=O)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>OO>[CH3:1][CH2:2][CH2:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][c:9]([cH:10][cH:11][c:12]1[NH:13][C:14](=[N:15][C:16](=[O:17])[O:18][CH3:19])[NH:20][C:21](=[O:22])[O:23][CH3:24])[S:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1|US07309792B2_0291
9.7.334|[C:3]-[N&H0&+0&D3:2](-[S:1])-C-C=C>>[C:3]-[N&H1&+0&D2:2]-[S:1]|C=CC[N:1]1[CH2:2][CH:3]([CH2:4][CH2:5][S:6]1(=[O:7])=[O:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[F:15])[N:16]1[CH2:17][C@@H:18]([O:19][C:20]1=[O:21])[CH2:22][NH:23][C:24]([CH3:25])=[O:26]>CC[O+](CC)[B-](F)(F)F.CCO.[Pd]>[CH3:25][C:24](=[O:26])[NH:23][CH2:22][C@H:18]1[CH2:17][N:16]([C:20]([O:19]1)=[O:21])[c:12]1[cH:11][cH:10][c:9]([c:14]([cH:13]1)[F:15])[CH:3]1[CH2:4][CH2:5][S:6]([NH:1][CH2:2]1)(=[O:7])=[O:8]|US20100069350A1_0914
9.7.334|[O:2]-[N&H0&+0&D3:1]1-C-c2:c:c:c:c:c:2-C-1>>[O:2]-[N&H2&+0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])[O:9][N:10]1Cc2ccccc2C1>NN>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])[O:9][NH2:10]|US09102671B2_0548
6.1.20|[C:2]-[N&H1&+0&D2:1]-S(=O)(=O)-c1:c:c:c:c:c:1>>[C:2]-[N&H2&+0&D1:1]|[O:1]=[C:2]([CH2:3][C@@H:4]([CH2:5][c:6]1[cH:7][c:8]([c:9]([cH:10][c:11]1[F:12])[F:13])[F:14])[NH:15]S(=O)(=O)c1ccccc1)[N:16]1[CH2:17][CH2:18][n:19]2[c:20]([n:21][n:22][c:23]2[CH2:24]1)[C:25]([F:26])([F:27])[F:28].[O:29]=[P:30]([OH:31])([OH:32])[OH:33]>CC(=O)O.CCO.Cl>[NH2:15][C@H:4]([CH2:5][c:6]1[cH:7][c:8]([c:9]([cH:10][c:11]1[F:12])[F:13])[F:14])[CH2:3][C:2](=[O:1])[N:16]1[CH2:17][CH2:18][n:19]2[c:23]([CH2:24]1)[n:22][n:21][c:20]2[C:25]([F:26])([F:27])[F:28].[O:29]=[P:30]([OH:31])([OH:32])[OH:33]|EP1995254A1_0216
6.1.20|[c:2]-[N&H1&+0&D2:1]-S(=O)(=O)-c1:c:c:c:c:c:1>>[c:2]-[N&H2&+0&D1:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([c:7]([cH:8][c:9]1[Cl:10])[NH:11]S(=O)(=O)c1ccccc1)[Cl:12]>O.O=S(=O)(O)O>[NH2:11][c:7]1[cH:8][c:9]([c:4]([cH:5][c:6]1[Cl:12])[N+:2]([O-:1])=[O:3])[Cl:10]|US20200290953A1_0298
9.7.61|[C:2]-[O&H0&+0&D2:1]-[C@&H1](-C)-c1:c:c:c:c:c:1>>[C:2]-[O&H1&+0&D1:1]|C[C@@H]([O:1][C:2](=[O:3])[C@H:4]([CH2:5][c:6]1[n:7][cH:8][n:9]2[c:10]1[CH2:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1-2)[N:19]1[CH2:20][CH2:21][C@@H:22]([CH2:23]1)[NH:24][C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])c1ccccc1>CO.[Pd]>[CH3:29][C:28]([CH3:30])([CH3:31])[O:27][C:25](=[O:26])[NH:24][C@H:22]1[CH2:21][CH2:20][N:19]([CH2:23]1)[C@@H:4]([CH2:5][c:6]1[n:7][cH:8][n:9]2[c:10]1[CH2:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1-2)[C:2](=[O:3])[OH:1]|US20200354382A1_0511
9.7.334|[C:2]-[N&H1&+0&D2:1]-[C@@&H1](-C)-c1:c:c:c:c:c:1>>[C:2]-[N&H2&+0&D1:1]|Cl.C[C@H]([NH:1][C@@H:2]1[CH2:3][N:4]2[CH2:5][CH2:6][CH:7]1[CH2:8][CH2:9]2)c1ccccc1>O.CC(=O)O.[Pd]>[NH2:1][C@@H:2]1[CH2:3][N:4]2[CH2:9][CH2:8][CH:7]1[CH2:6][CH2:5]2|US08841486B2_0143
7.9.22|[C&H3&D1:3]-[S&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:3]-[S&H0&+0&D2:2]-[C:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][C@H:5]([NH:6][C:7](=[O:8])[C@H:9]([CH2:10][c:11]1[cH:12][nH:13][c:14]2[c:15]1[cH:16][cH:17][cH:18][cH:19]2)[NH:20][C:21](=[O:22])[C@H:23]([CH2:24][CH2:25][C:26]([NH2:27])=[O:28])[NH:29][C:30](=[O:31])[C@@H:32]([NH:33][C:34](=[O:35])[C@H:36]([CH2:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[NH:44][C:45](=[O:46])[C@H:47]([CH2:48][C:49](=[O:50])[OH:51])[NH:52][C:53](=[O:54])[C@H:55]([CH2:56][CH2:57][C:58]([NH2:59])=[O:60])[NH:61][C:62](=[O:63])[C@H:64]([CH3:65])[NH:66][C:67](=[O:68])[C@H:69]([CH2:70][CH2:71][CH2:72][NH:73][C:74](=[NH:75])[NH2:76])[NH:77][C:78](=[O:79])[C@@H:80]([NH2:81])[CH2:82][CH2:83][CH2:84][NH:85][C:86](=[NH:87])[NH2:88])[CH:89]([CH3:90])[CH3:91])[C:92](=[O:93])[NH:94][C@@H:95]([CH2:96][CH2:97][S:98]([CH3:99])=O)[C:100](=[O:101])[NH:102][C@@H:103]([CH2:104][C:105]([NH2:106])=[O:107])[C:108](=[O:109])[NH:110][C@H:111]([C:112](=[O:113])[OH:114])[C@@H:115]([CH3:116])[OH:117]>O=C(O)CS>[CH3:1][CH:2]([CH3:3])[CH2:4][C@H:5]([NH:6][C:7](=[O:8])[C@H:9]([CH2:10][c:11]1[cH:12][nH:13][c:14]2[c:15]1[cH:16][cH:17][cH:18][cH:19]2)[NH:20][C:21](=[O:22])[C@H:23]([CH2:24][CH2:25][C:26]([NH2:27])=[O:28])[NH:29][C:30](=[O:31])[C@@H:32]([NH:33][C:34](=[O:35])[C@H:36]([CH2:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[NH:44][C:45](=[O:46])[C@H:47]([CH2:48][C:49](=[O:50])[OH:51])[NH:52][C:53](=[O:54])[C@H:55]([CH2:56][CH2:57][C:58]([NH2:59])=[O:60])[NH:61][C:62](=[O:63])[C@H:64]([CH3:65])[NH:66][C:67](=[O:68])[C@H:69]([CH2:70][CH2:71][CH2:72][NH:73][C:74](=[NH:75])[NH2:76])[NH:77][C:78](=[O:79])[C@@H:80]([NH2:81])[CH2:82][CH2:83][CH2:84][NH:85][C:86](=[NH:87])[NH2:88])[CH:89]([CH3:90])[CH3:91])[C:92](=[O:93])[NH:94][C@@H:95]([CH2:96][CH2:97][S:98][CH3:99])[C:100](=[O:101])[NH:102][C@@H:103]([CH2:104][C:105]([NH2:106])=[O:107])[C:108](=[O:109])[NH:110][C@H:111]([C:112](=[O:113])[OH:114])[C@@H:115]([CH3:116])[OH:117]|US20200246503A1_0180
9.7.60|[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:3]-[C&H1&+0&D2:2]=[O&H0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([OH:7])[CH:8]([NH:9][C:10]([CH3:11])=[O:12])[C:13](=[O:14])O>CC(=O)NC(C(=O)OC)C(O)CCCCC.CCCCCC(O)C(N)C(=O)O.CC(C)C[AlH]CC(C)C.CC(=O)OC(C)=O.CO>[CH3:11][C:10](=[O:12])[NH:9][CH:8]([CH:13]=[O:14])[CH:6]([OH:7])[CH2:5][CH2:4][CH2:3][CH2:2][CH3:1]|US20060229236A1_0281
7.9.4|[C&H3&D1:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][C:2](=O)[CH2:3][c:4]1[c:5]2[o:6][c:7]([cH:8][c:9]([c:10]2[cH:11][c:12]2[CH2:13][CH2:14][CH2:15][CH2:16][c:17]21)=[O:18])[C:19](=[O:20])[OH:21]>O.[Na+].Cl.O[Na].[BH4-]>[CH3:1][CH2:2][CH2:3][c:4]1[c:5]2[o:6][c:7]([cH:8][c:9]([c:10]2[cH:11][c:12]2[CH2:13][CH2:14][CH2:15][CH2:16][c:17]21)=[O:18])[C:19](=[O:20])[OH:21]|EP3738969A1_0219
7.2.1|[C&H3&D1:3]-[C&H0&+0&D3:2](-[N:1])=O>>[C&H3&D1:3]-[C&H2&+0&D2:2]-[N:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][C@@H:12]1[CH2:13][CH2:14][CH2:15][CH2:16][C@H:17]1[NH:18][C:19]([CH3:20])=O>O.CCOCC.[Li][AlH4]>[CH3:20][CH2:19][NH:18][C@@H:17]1[CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]1[NH:11][S:8](=[O:9])(=[O:10])[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH3:1]|US04568765A
9.7.60|[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[O&H0&D1:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=[O:9])O>C=CCO.CC(C)=O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH:8]=[O:9]|EP2150526B1_0159
7.9.4|[C&H3&D1:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C&H3&D1:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[Cl:15]>C#Cc1ccc(cc1)-c1ccccc1F.c1ccccc1.O=S(=O)(O)O>[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[Cl:15]|US07151105B2_1090
7.9.22|[C&H3&D1:3]-[S&H0&+0&D3:2](-[c:1])=O>>[C&H3&D1:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][S:2](=O)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][P+:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[Cl-:29]>CS(=O)c1ccc(cc1)CCl>[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][P+:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[Cl-:29]|US09533989B2_0285
9.7.334|[C&H3&D1:3]-[N&H0&+0&D3:2](-[C:1])-C>>[C&H3&D1:3]-[N&H1&+0&D2:2]-[C:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[CH2:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[CH:16]2[CH2:17][CH2:18][CH2:19][N:20]([CH3:21])C>CCOC(=O)Cl.c1ccccc1>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[CH2:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[CH:16]2[CH2:17][CH2:18][CH2:19][NH:20][CH3:21]|US20190315732A1_1725
9.7.140|[C:3]=[C&H0&+0&D3:2](-[F&H0&D1:1])-F>>[C:3]=[C&H1&+0&D2:2]-[F&H0&D1:1]|[CH3:1][CH2:2][CH2:3][C@@H:4]1[CH2:5][CH2:6][C@H:7]([CH2:8][CH2:9]1)[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH:16]=[C:17]([F:18])F>COCCO[AlH]OCCOC.Cc1ccccc1.c1ccccc1.O.[Na]>[CH3:1][CH2:2][CH2:3][C@@H:4]1[CH2:5][CH2:6][C@H:7]([CH2:8][CH2:9]1)[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)/[CH:16]=[CH:17]/[F:18]|EP3309138B1_0009
9.7.147|[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-N>>[O&H0&D1:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][C@@H:4]1[CH2:5][CH2:6][C@H:7]([CH2:8][CH2:9]1)[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[C:16](N)=[O:17])[O:18][CH2:19][CH3:20]>CCC[C@H]1CC[C@@H](CC1)c1ccc(cc1)O.O=S(Cl)Cl.ClC(Cl)Cl.[OH-].[K+]>[CH3:20][CH2:19][O:18][c:13]1[cH:12][cH:11][c:10]([cH:15][c:14]1[CH:16]=[O:17])[C@H:7]1[CH2:6][CH2:5][C@@H:4]([CH2:9][CH2:8]1)[CH2:3][CH2:2][CH3:1]|US08053431B2_0795
9.7.334|[C&H3&D1:3]-[N&H0&+0&D3:2](-[N:1])-C>>[C&H3&D1:3]-[N&H1&+0&D2:2]-[N:1]|[CH3:1][N:2](C)[N:3]=[C:4]1[CH:5]=[CH:6][C:7](=[C:8]([CH2:9]1)[F:10])[NH:11][C:12](=[O:13])[CH:14]([NH:15][C:16](=[O:17])[NH:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25])[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>CN.CC(=O)O>[CH3:1][NH:2][N:3]=[C:4]1[CH:5]=[CH:6][C:7](=[C:8]([CH2:9]1)[F:10])[NH:11][C:12](=[O:13])[CH:14]([NH:15][C:16](=[O:17])[NH:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25])[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1|US04904775A
7.9.2|[O&H1&D1:3]-[C&H0&+0&D3:2](-[c:1])=O>>[O&H1&D1:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[C:8](=O)[OH:9])[N+:10]([O-:11])=[O:12]>C1CCOC1>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[CH2:8][OH:9])[N+:10]([O-:11])=[O:12]|US08173749B2_1173
9.7.334|[C&H3&D1:3]-[N&H0&+0&D3:2](-[c:1])-C>>[C&H3&D1:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[N+:14]([O-:15])=[O:16])[N:17]([CH3:18])C)[C:19](=[O:20])[O:21][CH2:22][CH3:23]>CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O.CC(=O)O.[Pb+2]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[N+:14]([O-:15])=[O:16])[NH:17][CH3:18])[C:19](=[O:20])[O:21][CH2:22][CH3:23]|US07956183B2_0776
9.7.147|[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-N>>[C:3]-[C&H1&+0&D2:2]=[O&H0&D1:1]|[CH3:1][NH:2][CH:3]([CH2:4][CH2:5][C:6](N)=[O:7])[C:8]([CH3:9])=[O:10]>>[CH3:1][NH:2][CH:3]([CH2:4][CH2:5][CH:6]=[O:7])[C:8]([CH3:9])=[O:10]|US07390910B2_0415
7.2.1|[C:3]-[C&H0&+0&D3:2](-[N&H2&D1:1])=O>>[C:3]-[C&H2&+0&D2:2]-[N&H2&D1:1]|[NH2:1][C:2](=O)[CH2:3][CH:4]1[CH:5]2[CH2:6][CH2:7][CH:8]1[CH2:9][CH2:10]2>C1CCOC1.[Li][AlH4].O>[NH2:1][CH2:2][CH2:3][CH:4]1[CH:5]2[CH2:6][CH2:7][CH:8]1[CH2:9][CH2:10]2|US05587144A
7.2.1|[N&H2&D1:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H2&D1:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][c:6]1[cH:7][c:8]([c:9]([c:10]([cH:11]1)[O:12][CH3:13])[C:14]([NH2:15])=O)[O:16][CH3:17]>[Li][AlH4]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][c:6]1[cH:7][c:8]([c:9]([c:10]([cH:11]1)[O:12][CH3:13])[CH2:14][NH2:15])[O:16][CH3:17]|US20190062305A1_0895
7.9.2|[C:3]-[C&H0&+0&D3:2](-[O&H1&D1:1])=O>>[C:3]-[C&H2&+0&D2:2]-[O&H1&D1:1]|[CH3:1][CH:2]([C:3](=O)[OH:4])[C:5]1([CH2:6][CH2:7][CH2:8][CH2:9][CH:10]1[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[OH:17]>O.CCOCC.CCOC(C)=O.C1CCOC1.[Li][AlH4]>[CH3:1][CH:2]([CH2:3][OH:4])[C:5]1([CH2:6][CH2:7][CH2:8][CH2:9][CH:10]1[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[OH:17]|US07750185B2_0175
9.7.59|[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:3]-[C&H1&+0&D2:2]=[O&H0&D1:1]|[O:1]=[C:2](Cl)[CH2:3][CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17]>CC(C)(C)O[Al](OC(C)(C)C)OC(C)(C)C.COCCOCCOC.COCCOC.CCOCC.O=C=O.[Li+].[OH-]>[O:1]=[CH:2][CH2:3][CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17]|US05073544A
7.9.7|[N&H0&+0&D1:3]#[N&H0&+&D2:2]-[c:1]>>[N&H2&+0&D1:3]-[N&H1&+0&D2:2]-[c:1]|[N:1]#[N+:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[F:9])[Cl:10])[O:11][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16]1.F[B-](F)(F)F>C1CCOC1.Cl[Sn]Cl.O[K].O.Cl>[NH2:1][NH:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[F:9])[Cl:10])[O:11][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16]1|US08748435B2_0328
9.7.59|[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[O&H0&D1:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([cH:8][c:9]([cH:10][c:11]1[O:12][CH2:13][CH3:14])[C:15](=[O:16])Cl)[O:17][CH2:18][CH3:19]>c1cc2ccccc2nc1.[H][H].[S].[Pd]>[CH3:14][CH2:13][O:12][c:11]1[cH:10][c:9]([cH:8][c:7]([c:6]1[C:4](=[O:5])[O:3][CH2:2][CH3:1])[O:17][CH2:18][CH3:19])[CH:15]=[O:16]|US20020038055A1_0035
7.6.1|[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:3]-[C&H2&+0&D2:2]-[c:1]|[CH2:1]=[CH:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[OH:9]>C=Cc1ccc(cc1)O.C=Cc1cccc(c1)O.Cc1ccccc1>[CH3:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[OH:9]|EP0916668A1_0157
7.7.1|[C&H1&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[C&H3&+0&D1:3]-[C&H2&+0&D2:2]-[c:1]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[F:15]>c1ccccc1.O=S(=O)(O)O.[H][H].[Pd]>[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[F:15]|US20170197935A1_0070
7.9.8|[C&H1&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[F:15]>c1ccncc1.[H][H].[Pd]>[CH2:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[F:15]|US20200368721A1_0205
7.9.8|[C&H1&+0&D1:3]#[C&H0&+0&D2:2]-[C:1]>>[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[C:1]|[CH:1]#[C:2][C@@:3]1([CH2:4][CH2:5][C@H:6]2[C@@H:7]3[CH2:8][CH2:9][C:10]4=[CH:11][C:12]([CH2:13][CH2:14][C@@H:15]4[C@H:16]3[CH2:17][CH2:18][C@@:19]21[CH2:20][CH3:21])=[O:22])[OH:23]>c1ccncc1.[O-]C([O-])=O.[O-]C([O-])=O.[H][H].[Ca+2].[Pd+2]>[CH2:1]=[CH:2][C@@:3]1([CH2:4][CH2:5][C@H:6]2[C@@H:7]3[CH2:8][CH2:9][C:10]4=[CH:11][C:12]([CH2:13][CH2:14][C@@H:15]4[C@H:16]3[CH2:17][CH2:18][C@@:19]21[CH2:20][CH3:21])=[O:22])[OH:23]|US07592143B2_0546
7.3.1|[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[C:3]-[C&H2&+0&D2:2]-[N&H2&+0&D1:1]|[N:1]#[C:2][CH2:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][n:10]1>CCOCC.[Li][AlH4]>[NH2:1][CH2:2][CH2:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][n:10]1|US20150239824A1_0467
9.7.68|[c:3]-[N&H1&+0&D2:2]-[C&H1&+0&D2:1]=O>>[c:3]-[N&H0&+&D2:2]#[C&H0&-&D1:1]|[NH2:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[NH:11][CH:12]=O>CCN(CC)CC.c1ccccc1.O=C(Cl)Cl>[C-:12]#[N+:11][c:10]1[cH:9][cH:8][cH:7][cH:6][c:5]1[O:4][C:2]([NH2:1])=[O:3]|US10870663B2_0665
8.8.18|[C&H3&+0&D1:3]-[C&H2&+0&D2:2]-[c:1]>>[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][c:3]1[n:4][cH:5][cH:6][n:7][c:8]1[CH3:9]>CCc1nccnc1CC>[CH2:1]=[CH:2][c:3]1[n:4][cH:5][cH:6][n:7][c:8]1[CH3:9]|US05401895A
8.8.18|[C&H3&+0&D1:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[C:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]=[C:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>O=C(c1ccccc1)c1ccccc1>[CH2:1]=[CH:2][CH2:3][CH2:4][CH2:5][CH:6]=[C:7]([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US20110230476A1_1172
8.1.4|[C:3]-[C&H2&+0&D2:2]-[O&H1&+0&D1:1]>>[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]|[CH3:1][C:2]1[CH2:3][C:4]2([CH2:5][C:6]([C:7]=1[CH2:8][OH:9])([CH3:10])[CH3:11])[O:12][CH2:13][CH2:14][O:15]2>O=[Mn]=O.ClCCl>[CH3:1][C:2]1[CH2:3][C:4]2([CH2:5][C:6]([C:7]=1[CH:8]=[O:9])([CH3:10])[CH3:11])[O:12][CH2:13][CH2:14][O:15]2|US05705531A
8.1.4|[O&H1&+0&D1:3]-[C&H2&+0&D2:2]-[c:1]>>[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:16][OH:17]>C1N2CN3CN1CN(C2)C3>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH:16]=[O:17]|US10308644B2_1613
7.6.1|[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[C:1]>>[C&H3&+0&D1:3]-[C&H2&+0&D2:2]-[C:1]|[CH2:1]=[CH:2][C:3]1[CH2:4][S:5][C@@H:6]2[C@@H:7]([C:8]([N:9]2[C:10]=1[C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[NH:19][C:20](=[O:21])[CH2:22][O:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>CCOC(C)=O.[H][H]>[CH3:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[C@@H:7]([C:8]([N:9]2[C:10]=1[C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[NH:19][C:20](=[O:21])[CH2:22][O:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1|US05053548A
7.7.1|[C&H1&+0&D1:3]#[C&H0&+0&D2:2]-[C:1]>>[C&H3&+0&D1:3]-[C&H2&+0&D2:2]-[C:1]|[CH:1]#[C:2][CH2:3][N:4]1[CH2:5][CH2:6][CH:7]2[C:8]([CH2:9]1)=[C:10]1[C:11](=[CH:12][C:13](=[CH:14][C:15]1([OH:16])[OH:17])[CH:18]([CH3:19])[CH2:20][CH2:21][CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29])[O:30][C:31]2([CH3:32])[CH3:33]>CCO.[H][H]>[CH3:19][CH:18]([CH2:20][CH2:21][CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29])[C:13]1[CH:12]=[C:11]2[O:30][C:31]([CH:7]3[CH2:6][CH2:5][N:4]([CH2:9][C:8]3=[C:10]2[C:15]([CH:14]=1)([OH:16])[OH:17])[CH2:3][CH2:2][CH3:1])([CH3:32])[CH3:33]|US04130649A
7.9.1|[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[O&H1&+0&D1:3]-[C&H2&+0&D2:2]-[c:1]|[O:1]=[CH:2][c:3]1[c:4]([n:5][n:6]([c:7]1[Cl:8])-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[Cl:21]>O.[Na+].CN(C)C=O.[BH4-]>[OH:1][CH2:2][c:3]1[c:4]([n:5][n:6]([c:7]1[Cl:8])-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[Cl:21]|US06313122B1
9.7.68|[C:3]-[N&H1&+0&D2:2]-[C&H1&+0&D2:1]=O>>[C:3]-[N&H0&+&D2:2]#[C&H0&-&D1:1]|[CH3:1][C:2]1[CH2:3][S:4][C@@H:5]2[C@@H:6]([C:7]([N:8]2[C:9]=1[C:10](=[O:11])[O:12][CH:13]([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)=[O:26])[NH:27][CH:28]=O>O=C(Cl)Cl.ClCCl.c1ccncc1>[C-:28]#[N+:27][C@@H:6]1[C:7]([N:8]2[C:9](=[C:2]([CH2:3][S:4][C@H:5]12)[CH3:1])[C:10](=[O:11])[O:12][CH:13]([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)=[O:26]|US04771051A
7.9.1|[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C:3]-[C&H2&+0&D2:2]-[O&H1&+0&D1:1]|[CH3:1][CH:2]1[O:3][C@H:4]([CH2:5][CH:6]2[C@@H:7]1[O:8][C:9]([O:10]2)([CH3:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[O:18][C@H:19]1[CH2:20][CH2:21][C@@:22]2([CH:23]3[CH2:24][CH2:25][C@@:26]4([C@H:27]([CH2:28][CH2:29][C@@:30]4([CH:31]3[CH2:32][CH2:33][C@@:34]2([CH2:35]1)[OH:36])[OH:37])[C:38]1=[CH:39][C:40]([O:41][CH2:42]1)=[O:43])[CH3:44])[CH:45]=[O:46]>C1COCCO1.O=S(=O)(O)O.[Na+].[BH4-]>[CH3:11][C:9]1([O:10][CH:6]2[CH2:5][C@@H:4]([O:3][CH:2]([C@H:7]2[O:8]1)[CH3:1])[O:18][C@H:19]1[CH2:20][CH2:21][C@@:22]2([CH:23]3[CH2:24][CH2:25][C@@:26]4([C@H:27]([CH2:28][CH2:29][C@@:30]4([CH:31]3[CH2:32][CH2:33][C@@:34]2([CH2:35]1)[OH:36])[OH:37])[C:38]1=[CH:39][C:40]([O:41][CH2:42]1)=[O:43])[CH3:44])[CH2:45][OH:46])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US09974790B2_0621
7.3.1|[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[N&H2&+0&D1:3]-[C&H2&+0&D2:2]-[c:1]|Cl.[CH3:1][C:2]([CH3:3])([CH3:4])[NH:5][CH2:6][CH:7]([OH:8])[CH2:9][O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[C:17]#[N:18])[Cl:19]>N.CO.[Ni]>[CH3:1][C:2]([CH3:3])([CH3:4])[NH:5][CH2:6][CH:7]([OH:8])[CH2:9][O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[CH2:17][NH2:18])[Cl:19]|US04920128A
10.1.1|[Br&H0&-&D0:3].[C&H3&+0&D1:2]-[C:1]>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([c:7]([c:8]([cH:9]1)[C:10]([CH3:11])([CH3:12])[CH3:13])[O:14][CH2:15][C:16](=[O:17])[O:18][CH3:19])[C:20]([CH3:21])([CH3:22])[CH3:23].[Br-:24]>CCOC(C)=O>[CH3:21][C:20]([CH3:22])([CH3:23])[c:6]1[cH:5][c:4]([cH:9][c:8]([c:7]1[O:14][CH2:15][C:16](=[O:17])[O:18][CH3:19])[C:10]([CH3:11])([CH3:12])[CH3:13])[C:2](=[O:3])[CH2:1][Br:24]|US20170050980A1_0621
9.7.139|[Br&H0&D1:3]-[C&H1&+0&D3:2](-[c:1])-Br>>[Br&H0&D1:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[C:11](=[O:12])[OH:13])[CH:14]([Br:15])Br>>[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[C:11](=[O:12])[OH:13])[CH2:14][Br:15]|US20190375692A1_0087
1.2.1|[N&H4&+&D0:3].[C:2]-[C&H1&+0&D2:1]=O>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[NH4+:1].[Br-].[CH3:2][CH2:3][CH2:4][CH2:5][CH2:6][C@@H:7]([CH2:8][CH:9]=O)[O:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>[Na+].Cl.CO.N#C[BH3-]>[CH3:2][CH2:3][CH2:4][CH2:5][CH2:6][C@@H:7]([CH2:8][CH2:9][NH2:1])[O:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US20160008490A1_0309
1.7.6|[C&H3&+0&D1:3]-I.[C:2]-[O&H0&-&D1:1]>>[C&H3&+0&D1:3]-[O&H0&+0&D2:1]-[C:2]|[O-:1][C:2](=[O:3])[C:4]1([CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[NH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[CH3:24]I.[Na+]>CN(C)P(=O)(N(C)C)N(C)C.Cc1ccccc1>[CH3:24][O:1][C:2](=[O:3])[C:4]1([CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[NH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20160137639A1_3267
9.7.139|[Br&H0&D1:3]-[C&H1&+0&D3:2](-[C:1])-Br>>[Br&H0&D1:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][C:2]([CH3:3])([C:4](=[O:5])[CH:6]([Br:7])Br)[CH:8]([CH:9]=[C:10]([Cl:11])[C:12]([F:13])([F:14])[F:15])[O:16][S:17]([CH3:18])(=[O:19])=[O:20]>>[CH3:18][S:17](=[O:19])(=[O:20])[O:16][CH:8]([CH:9]=[C:10]([Cl:11])[C:12]([F:13])([F:14])[F:15])[C:2]([CH3:1])([CH3:3])[C:4](=[O:5])[CH2:6][Br:7]|EP0325998A2_0052
1.2.1|[N&H4&+&D0:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH:16]=O.[NH4+:17].[Cl-]>C1CCOC1.N#C[BH3-].CO.O[Na].[NH4+].[Na+].Cl.[OH-]>[CH3:13][C:12]([CH3:14])([CH3:15])[c:9]1[cH:8][c:7]([cH:6][c:5]([c:10]1[OH:11])[C:2]([CH3:1])([CH3:3])[CH3:4])[CH2:16][NH2:17]|US20080234318A1_0237
6.1.5|[C:3]-[N&H0&+0&D3:2](-[S:1])-C-c1:c:c:c:c:c:1>>[C:3]-[N&H1&+0&D2:2]-[S:1]|[CH3:1][CH2:2][CH2:3][CH:4]1[C:5]([N:6]([S:7]([N:8]1[CH3:9])(=[O:10])=[O:11])Cc1ccccc1)=[O:12]>[NH4+].CO.[O-]C=O.[Pd]>[CH3:1][CH2:2][CH2:3][CH:4]1[C:5]([NH:6][S:7]([N:8]1[CH3:9])(=[O:10])=[O:11])=[O:12]|US07781422B2_0113
7.9.20|[c:4]-[P&H0&+0&D4:3](-[c:2])(-[c:1])=O>>[c:4]-[P&H0&+0&D3:3](-[c:2])-[c:1]|O=[P:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>[Cl-].[Cl-].[Cl-].[Cl-].[H][H].[Si+4].[S]>[cH:17]1[cH:16][cH:15][c:14]([cH:19][cH:18]1)[P:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US05530150A
9.7.60|[O:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-O>>[O:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([n:6][c:7]([n:8]1)[C:9]1([O:10][C:11]([c:12]2[c:13]([cH:14][cH:15][n:16][c:17]21)-[c:18]1[cH:19][cH:20][cH:21][s:22]1)=[O:23])O)[O:24][CH3:25]>[Na+].CCO.[BH4-]>[CH3:1][O:2][c:3]1[cH:4][c:5]([n:6][c:7]([n:8]1)[CH:9]1[O:10][C:11]([c:12]2[c:13]([cH:14][cH:15][n:16][c:17]21)-[c:18]1[cH:19][cH:20][cH:21][s:22]1)=[O:23])[O:24][CH3:25]|US08217032B2_0394
1.1.3|[C&H3&+0&D1:3]-I.[N&H2&+0&D1:2]-[c:1]>>[C&H3&+0&D1:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([OH:7])[CH2:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[NH2:16])[CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1.[CH3:23]I>c1ccncc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([OH:7])[CH2:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[NH:16][CH3:23])[CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1|EP3555068B1_0156
1.1.3|[C&H3&+0&D1:3]-I.[N&H1&+0&D1:2]=[S:1]>>[C&H3&+0&D1:3]-[N&H0&+0&D2:2]=[S:1]|[CH3:1][n:2]1[c:3]2[n:4][cH:5][c:6]([cH:7][c:8]2[n:9][c:10]1-[c:11]1[n:12][cH:13][c:14]([cH:15][c:16]1[S:17](=[NH:18])(=[O:19])[CH2:20][CH3:21])[C:22]([F:23])([F:24])[F:25])[C:26]([F:27])([F:28])[F:29].[CH3:30]I>COCCOC.[NaH]>[CH3:21][CH2:20][S:17](=[O:19])(=[N:18][CH3:30])[c:16]1[cH:15][c:14]([cH:13][n:12][c:11]1-[c:10]1[n:9][c:8]2[cH:7][c:6]([cH:5][n:4][c:3]2[n:2]1[CH3:1])[C:26]([F:27])([F:28])[F:29])[C:22]([F:23])([F:24])[F:25]|US20200383991A1_0596
9.7.182|[O&H2&+0&D0:3].[c:2]-[C&H0&+0&D2:1]#N>>[O&H0&+0&D1:3]=[C&H1&+0&D2:1]-[c:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[NH:5][c:6]1[cH:7][c:8]([c:9]([c:10]([n:11]1)[NH:12][C:13]([CH3:14])([CH3:15])[CH3:16])[C:17]#N)[CH3:18].[OH2:19]>O=CO.[Ni]>[CH3:18][c:8]1[cH:7][c:6]([n:11][c:10]([c:9]1[CH:17]=[O:19])[NH:12][C:13]([CH3:14])([CH3:15])[CH3:16])[NH:5][C:2]([CH3:1])([CH3:3])[CH3:4]|EP3708163A1_0039
9.7.60|[C:4]-[C&H0&+0&D4:3](-[C:2])(-[O:1])-O>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[O:1]|[CH3:1][CH:2]1[CH2:3][CH2:4][C:5]2=[C:6]([C:7]([O:8][C:9]2([CH2:10]1)O)=[O:11])[CH3:12]>[Na+].[BH4-]>[CH3:12][C:6]1[C:7]([O:8][CH:9]2[CH2:10][CH:2]([CH2:3][CH2:4][C:5]=12)[CH3:1])=[O:11]|US09328134B2_0185
10.1.1|[Br&H1&+0&D0:3].[C&H3&+0&D1:2]-[c:1]>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:2]-[c:1]|[BrH:1].[CH3:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][c:9]([n:10][c:11]1-[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[N+:18]([O-:19])=[O:20])-[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[CH3:27].CC(=O)O>O.CC(=O)O.Br[Br-]Br.c1cc[nH+]cc1>[CH3:2][O:3][C:4](=[O:5])[c:6]1[c:11]([n:10][c:9]([n:8][c:7]1[CH2:27][Br:1])-[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)-[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[N+:18]([O-:19])=[O:20]|EP2513046B1_0031
1.2.9|[C&H3&+0&D1:3]-O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&+0&D1:3]-[N&H1&+0&D2:1]-[C:2]|[CH3:1]O.[NH2:2]/[C:3](=[C:4]1/[S:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[C:12]1=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>C[NH3+].CC([O-])=O.CS(C)=O>[CH3:1][NH:2]/[C:3](=[C:4]1/[S:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[C:12]1=[O:13])[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|US20200071301A1_1494
9.7.173|[O&H2&+0&D0:3].[c:2]-[C&H2&+0&D2:1]-N>>[O&H1&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|[OH2:1].[CH3:2][CH:3]([CH3:4])[c:5]1[n:6][cH:7][cH:8][c:9]2[c:10]1[cH:11][cH:12][cH:13][c:14]2[CH2:15]N>CC(=O)O.O=NO[Na].O[Na]>[CH3:2][CH:3]([CH3:4])[c:5]1[n:6][cH:7][cH:8][c:9]2[c:14]([cH:13][cH:12][cH:11][c:10]21)[CH2:15][OH:1]|EP1867730A1_0044
1.2.10|[C&H2&+0&D1:3]=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&+0&D1:3]-[N&H1&+0&D2:2]-[c:1]|[CH2:1]=O.[CH3:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[NH2:9])[N+:10]([O-:11])=[O:12]>O.O=S(=O)(O)O>[CH3:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[NH:9][CH3:1])[N+:10]([O-:11])=[O:12]|EP3286166B1_0252
1.7.4|[C&H3&+0&D1:3]-I.[O&H1&+0&D1:2]-[c:1]>>[C&H3&+0&D1:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][c:2]1[c:3]([cH:4][cH:5][c:6]2[c:7]1[CH2:8][c:9]1[cH:10][c:11]([cH:12][cH:13][c:14]1-2)[OH:15])[CH2:16][C:17](=[O:18])[OH:19].[CH3:20]I>CC(C)=O.O=C(O[K])O[K]>[CH3:20][O:15][c:11]1[cH:12][cH:13][c:14]2[c:9]([cH:10]1)[CH2:8][c:7]1[c:2]([c:3]([cH:4][cH:5][c:6]1-2)[CH2:16][C:17](=[O:18])[OH:19])[CH3:1]|EP2928471B1_0344
9.7.293|[C:3]-[O&H1&+0&D1:2].[O&H1&+0&D1:1]-O>>[C:3]-[O&H0&+0&D2:2]-[O&H1&+0&D1:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[S:10](=[O:11])(=[O:12])[OH:13].O[OH:14]>O=S(=O)(O)O.ClCCl>[O:11]=[S:10](=[O:12])([OH:13])[c:8]1[cH:7][cH:6][cH:5][c:4]([cH:9]1)[C:2](=[O:1])[O:3][OH:14]|EP0366041A2_0043
9.7.60|[C:4]-[C&H0&+0&D4:3](-[O:2])(-[c:1])-O>>[C:4]-[C&H1&+0&D3:3](-[O:2])-[c:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[Cl:10])[C:11]1([O:12][C@@H:13]([C@H:14]([C@@H:15]([C@H:16]1[O:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[O:25][CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[O:33][CH2:34][c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1)[CH2:41][O:42][CH2:43][c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1)O>>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[Cl:10])[CH:11]1[O:12][C@@H:13]([C@H:14]([C@@H:15]([C@H:16]1[O:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[O:25][CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[O:33][CH2:34][c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1)[CH2:41][O:42][CH2:43][c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1|US20190055226A1_0472
1.2.11|[C&H2&+0&D1:3]=O.[N&H2&+0&D1:2]-[N:1]>>[C&H2&+0&D1:3]=[N&H0&+0&D2:2]-[N:1]|[CH2:1]=O.[CH3:2][N:3]([CH3:4])[C:5](=[O:6])[N:7]([NH2:8])[c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)[Cl:15])[F:16]>CN(C)C(=O)N(N=Cc1ccccc1)c1ccc(c(c1)Cl)F.CN(C)C(=O)Cl.NC(=O)N(N)c1ccccc1.Fc1ccc(cc1Cl)NN=Cc1ccccc1>[CH2:1]=[N:8][N:7]([C:5](=[O:6])[N:3]([CH3:2])[CH3:4])[c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)[Cl:15])[F:16]|US09598374B2_0687
1.2.9|[C&H3&+0&D1:3]-O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&+0&D1:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]([C:10](=[O:11])[OH:12])[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[NH2:19].[CH3:20]O>COS(=O)(=O)OC.[Na+].[OH-]>[CH3:20][NH:19][c:16]1[cH:15][cH:14][c:13]([cH:18][cH:17]1)[CH:9]([NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[C:10](=[O:11])[OH:12]|US20200262829A1_0369
9.5.4|[c:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-O>>[c:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|O[CH2:1][CH2:2][c:3]1[cH:4][c:5]([n:6][o:7]1)-[c:8]1[cH:9][n:10][cH:11][cH:12][cH:13]1>[Na+].O=S(=O)(O)O.[OH-]>[CH2:1]=[CH:2][c:3]1[cH:4][c:5]([n:6][o:7]1)-[c:8]1[cH:13][cH:12][cH:11][n:10][cH:9]1|US09751881B2_0297
9.5.4|[S:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-O>>[S:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[O:1]=[S:2](=[O:3])([CH2:4][CH2:5]O)[CH:6]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1>CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>[CH2:5]=[CH:4][S:2](=[O:1])(=[O:3])[CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1|EP0213944B1_0014
7.9.20|[C:4]-[P&H0&+0&D4:3](-[C:2])(-[c:1])=O>>[C:4]-[P&H0&+0&D3:3](-[C:2])-[c:1]|O=[P:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[SH:8]1[C:9](=[CH:10][c:11]2[c:12]1[cH:13][cH:14][c:15]1[c:16]2[cH:17][cH:18][cH:19][cH:20]1)[P:21]([c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)([CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]1)[CH:40]1[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]1>Cc1ccccc1C.CCN(CC)CC>[CH:10]1=[C:9]([SH:8]([c:12]2[c:11]1[c:16]1[cH:17][cH:18][cH:19][cH:20][c:15]1[cH:14][cH:13]2)[c:7]1[cH:6][cH:5][cH:4][cH:3][c:2]1[P:1]([CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]1)[CH:40]1[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]1)[P:21]([c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1|US04008281A
1.7.7|[C&H3&+0&D1:3]-O.[O&H1&+0&D1:2]-[c:1]>>[C&H3&+0&D1:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1]O.[CH3:2][O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[N:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[C@@H:16]1[CH2:17][c:18]2[cH:19][cH:20][cH:21][c:22]([c:23]2[CH2:24][C@H:25]1[OH:26])[OH:27]>C=[N+]=[N-]>[CH3:2][O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[N:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[C@@H:16]1[CH2:17][c:18]2[cH:19][cH:20][cH:21][c:22]([c:23]2[CH2:24][C@H:25]1[OH:26])[O:27][CH3:1]|US08987461B2_0521
9.7.173|[O&H2&+0&D0:3].[C:2]-[C&H2&+0&D2:1]-N>>[O&H1&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[OH2:1].[CH3:2][CH:3]([CH2:4]N)[c:5]1[cH:6][cH:7][c:8]2[O:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][c:17]2[cH:18]1>[Na+].CC(=O)O.[O-]N=O>[CH3:2][CH:3]([CH2:4][OH:1])[c:5]1[cH:6][cH:7][c:8]2[O:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][c:17]2[cH:18]1|US20190359608A1_1091
9.7.60|[C:4]-[C&H0&+0&D4:3](-[C:2])(-[C:1])-O>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]|Cl.[ClH:1].[CH3:2][NH:3][CH2:4][C:5]1([CH2:6][O:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[O:14][CH2:15]1)O>O.CCO.CCOCC.O=CNCC1(COc2ccccc2OC1)O.O[Na].[Li][AlH4]>[ClH:1].[CH3:2][NH:3][CH2:4][CH:5]1[CH2:6][O:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[O:14][CH2:15]1|US20170008830A1_0106
1.8.6|[C&H3&+0&D1:3]-I.[C:2]-[S&H1&+0&D1:1]>>[C&H3&+0&D1:3]-[S&H0&+0&D2:1]-[C:2]|[CH3:1][O:2][CH:3]([CH2:4][CH:5]([CH3:6])[CH2:7][CH2:8][CH2:9][C:10]([CH3:11])([CH3:12])[SH:13])[O:14][CH3:15].[CH3:16]I>[Na+].C[O-].CO>[CH3:1][O:2][CH:3]([CH2:4][CH:5]([CH3:6])[CH2:7][CH2:8][CH2:9][C:10]([CH3:11])([CH3:12])[S:13][CH3:16])[O:14][CH3:15]|US20200095212A1_0306
7.9.16|[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-S-C-C>>[C:3]-[C&H1&+0&D2:2]=[O&H0&D1:1]|CCS[C:1](=[O:2])[C@@H:3]([CH3:4])[NH:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>CC[SiH](CC)CC.CC(C)=O.[Pd]>[CH3:4][C@H:3]([CH:1]=[O:2])[NH:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US09499521B2_0280
1.2.1|[N&H3&+0&D0:3].[C:2]-[C&H1&+0&D2:1]=O>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[NH3:1].O=[CH:2][CH2:3][N:4]1[CH:5]=[N:6][CH2:7][CH2:8][CH2:9]1>CCO.[H][H].[Ni]>[NH2:1][CH2:2][CH2:3][N:4]1[CH:5]=[N:6][CH2:7][CH2:8][CH2:9]1|US20170067084A1_0270
9.7.186|[O&H0&-&D1:3]-[N&H0&+&D3:2](-[c:1])=O>>[O&H1&+0&D1:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][CH2:3][N:4]1[C:5]([CH2:6][N:7]=[C:8]([c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]21)[N+:15]([O-:16])=O)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:23]>C1CCOC1.CC([O-])=O.Cl[Sn]Cl.CO.O.O.O.O.O.[Na+]>[CH3:1][O:2][CH2:3][N:4]1[C:5]([CH2:6][N:7]=[C:8]([c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]21)[NH:15][OH:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:23]|EP3705471A1_1204
7.9.20|[C:4]-[P&H0&+0&D4:3](-[C:2])(-[C:1])=O>>[C:4]-[P&H0&+0&D3:3](-[C:2])-[C:1]|[CH3:1][CH2:2][CH2:3][CH2:4][P:5](=O)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13]>COB(OC)OC.CC[Al](CC)CC.Cc1ccccc1>[CH3:1][CH2:2][CH2:3][CH2:4][P:5]([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13]|US20150065738A1_0145
9.5.5|[c:3]-[C&H1&+0&D2:2]=[N&H0&+0&D2:1]-O>>[c:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][c:12]([o:13]1)[CH:14]=[N:15]O>O.CCOCC.CC(=O)OC(C)=O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][c:12]([o:13]1)[C:14]#[N:15]|US04048187A
9.7.60|[c:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-O>>[c:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[O:1]=[C:2]1[CH2:3][CH2:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[NH:11]1)[C:12](O)([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[c:19]1[cH:20][n:21][cH:22][cH:23][cH:24]1>[Na+].O=C(O)C(F)(F)F.[H][H].[BH4-]>[O:1]=[C:2]1[CH2:3][CH2:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[NH:11]1)[CH:12]([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[c:19]1[cH:24][cH:23][cH:22][n:21][cH:20]1|US10040767B2_0557
1.8.6|[C&H3&+0&D1:3]-I.[S&H1&+0&D1:2]-[c:1]>>[C&H3&+0&D1:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])[n:4]1[n:5][c:6]([n:7][c:8]1[SH:9])[OH:10].[CH3:11]I>CCN(CC)CC.CO>[CH3:1][CH:2]([CH3:3])[n:4]1[n:5][c:6]([n:7][c:8]1[S:9][CH3:11])[OH:10]|EP3683222A1_2079
9.5.4|[C:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-O>>[C:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([OH:7])[CH2:8][CH2:9][CH2:10][CH:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18](=[O:19])[OH:20])[C:21](=[O:22])[CH2:23][CH2:24]O>[O-]C(=O)Cl.ClC(Cl)Cl>[CH2:24]=[CH:23][C:21](=[O:22])[CH:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18](=[O:19])[OH:20])[CH2:10][CH2:9][CH2:8][CH:6]([OH:7])[CH2:5][CH2:4][CH2:3][CH2:2][CH3:1]|US04695654A
10.1.1|[Br&H1&+0&D0:3].[C&H3&+0&D1:2]-[C:1]>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:2]-[C:1]|[BrH:1].[CH3:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]12>CCOC(C)=O.ClC(Cl)Cl.Br[Cu]Br>[O:4]=[C:3]([CH2:2][Br:1])[c:5]1[cH:6][cH:7][cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]12|EP3344997B1_0296
9.7.60|[C:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-O>>[C:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[CH2:9][N:10]([CH:11]([C:12]2(O)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[CH3:19])[CH3:20]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[CH2:9][N:10]([CH:11]([CH:12]2[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[CH3:19])[CH3:20]|US08436015B2_0251
1.2.10|[C&H2&+0&D1:3]=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&+0&D1:3]-[N&H1&+0&D2:1]-[C:2]|Cl.[CH2:1]=O.[CH3:2][O:3][c:4]1[cH:5][c:6]2[CH2:7][CH2:8][O:9][CH:10]([c:11]2[cH:12][c:13]1[O:14][CH3:15])[CH2:16][NH2:17]>Cl>[CH3:2][O:3][c:4]1[cH:5][c:6]2[CH2:7][CH2:8][O:9][CH:10]([c:11]2[cH:12][c:13]1[O:14][CH3:15])[CH2:16][NH:17][CH3:1]|US20200361941A1_0922
1.2.11|[C&H2&+0&D1:3]=O.[N&H2&+0&D1:2]-[O:1]>>[C&H2&+0&D1:3]=[N&H0&+0&D2:2]-[O:1]|Cl.[CH2:1]=O.[NH2:2][O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1>O.[Na+].[OH-]>[CH2:1]=[N:2][O:3][CH2:4][c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1|US20200181159A1_0496
9.7.22|[N&H4&+&D0:3].[C:2]-[C&H2&+0&D2:1]-Br>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[NH4+:1].[CH3:2][C:3]1([O:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[C:11](=[C:12]1[CH2:13]Br)[n:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1=[O:20])[N+:21]([O-:22])=[O:23])[CH3:24].[OH-]>CCO>[CH3:2][C:3]1([O:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[C:11](=[C:12]1[CH2:13][NH2:1])[n:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1=[O:20])[N+:21]([O-:22])=[O:23])[CH3:24]|EP2358710B1_0077
7.9.23|[C&H3&D1:3]-[S&H0&+0&D4:2](-[c:1])(=O)=O>>[C&H3&D1:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[Cl:9])-[c:10]1[n:11][o:12][c:13]([c:14]1-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[S:21]([CH3:22])(=O)=O)[CH3:23]>CC(=O)OC(C)=O.COc1ccc(cc1Cl)C(Cc1ccc(cc1)SC)=NO.[O-]S(=O)(=O)OO.[K+]>[CH3:22][S:21][c:18]1[cH:19][cH:20][c:15]([cH:16][cH:17]1)-[c:14]1[c:13]([o:12][n:11][c:10]1-[c:6]1[cH:5][cH:4][c:3]([c:8]([cH:7]1)[Cl:9])[O:2][CH3:1])[CH3:23]|US06541646B2
9.7.255|[C:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-I>>[C:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[N:1]#[C:2][C:3]([F:4])([F:5])[C:6]([F:7])([F:8])[O:9][C:10]([F:11])([F:12])[C:13]([F:14])([F:15])[CH2:16][CH2:17]I>CCCN(CCC)CCC.COCCOCCOC>[CH2:17]=[CH:16][C:13]([F:14])([F:15])[C:10]([F:11])([F:12])[O:9][C:6]([F:7])([F:8])[C:3]([F:4])([F:5])[C:2]#[N:1]|US05684111A
9.7.39|[N&H4&+&D0:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[NH4+:1].Cl.Cl.[O:2]=[C:3]([CH2:4][N:5]1[CH2:6][CH2:7][N:8]([CH2:9][CH2:10]1)[CH2:11][CH2:12]Cl)[N:13]1[c:14]2[n:15][cH:16][cH:17][cH:18][c:19]2[NH:20][C:21]([c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]21)=[O:28].[OH-]>>[NH2:1][CH2:12][CH2:11][N:8]1[CH2:9][CH2:10][N:5]([CH2:6][CH2:7]1)[CH2:4][C:3](=[O:2])[N:13]1[c:27]2[cH:26][cH:25][cH:24][cH:23][c:22]2[C:21]([NH:20][c:19]2[cH:18][cH:17][cH:16][n:15][c:14]21)=[O:28]|US10435377B2_0405
9.7.182|[O&H2&+0&D0:3].[C:2]-[C&H0&+0&D2:1]#N>>[O&H0&+0&D1:3]=[C&H1&+0&D2:1]-[C:2]|[OH2:1].N#[C:2][C:3]1([CH2:4][CH2:5][C:6]([CH2:7][CH2:8]1)=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>O[Na].C1CCOC1.[Li][AlH4]>[O:9]=[C:6]1[CH2:7][CH2:8][C:3]([CH2:4][CH2:5]1)([CH:2]=[O:1])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|EP3072884B1_0189
9.7.60|[C:4]-[C&H0&+0&D4:3](-[C:2])(-[c:1])-O>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[CH2:10][C:11]([CH2:12]1)(O)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[O:19][CH3:20]>CCO.O=[Cl](O)(O)O.[H][H].[Pd]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[CH2:10][CH:11]([CH2:12]1)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[O:19][CH3:20]|EP3753926A1_0350
9.5.5|[C:3]-[C&H1&+0&D2:2]=[N&H0&+0&D2:1]-O>>[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]([CH:10]=[N:11]O)=[C:12]([Cl:13])[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[O:20][CH3:21]>CC(=O)OC(C)=O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]([C:10]#[N:11])=[C:12]([Cl:13])[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[O:20][CH3:21]|US10538512B2_0670
9.7.22|[N&H4&+&D0:3].[c:2]-[C&H2&+0&D2:1]-Br>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|[NH4+:1].[N:2]#[C:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10]Br.[OH-]>C1COCCO1>[N:2]#[C:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10][NH2:1]|EP2590956B1_0269
9.7.60|[N:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-O>>[N:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C:6]2=[N:7][CH2:8][CH2:9][N:10]2[C:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)(O)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>[Na+].O=C(O)C(F)(F)F.[BH4-]>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C:6]2=[N:7][CH2:8][CH2:9][N:10]2[CH:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|EP3750885A1_0472
1.2.11|[C&H2&+0&D1:3]=O.[C:2]-[N&H2&+0&D1:1]>>[C&H2&+0&D1:3]=[N&H0&+0&D2:1]-[C:2]|[CH2:1]=O.[CH3:2][C:3]([CH3:4])([NH2:5])[c:6]1[cH:7][c:8]([cH:9][cH:10][cH:11]1)[Cl:12]>[Na+].[O-]C(=O)O>[CH2:1]=[N:5][C:3]([CH3:2])([CH3:4])[c:6]1[cH:11][cH:10][cH:9][c:8]([cH:7]1)[Cl:12]|US20020049223A1_0769
1.7.4|[C&H3&+0&D1:3]-I.[C:2]-[O&H1&+0&D1:1]>>[C&H3&+0&D1:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH3:6])[c:7]1[cH:8][cH:9][c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[cH:16]1)[CH2:17][OH:18].[CH3:19]I>CC(C(=O)O)c1ccc2cc(ccc2c1)CO.c1ccccc1.Cl.[NaH]>[CH3:19][O:18][CH2:17][c:12]1[cH:13][cH:14][c:15]2[cH:16][c:7]([cH:8][cH:9][c:10]2[cH:11]1)[CH:5]([CH3:6])[C:3](=[O:4])[O:2][CH3:1]|EP3468966B1_0738
1.1.3|[C&H3&+0&D1:3]-I.[C:2]-[N&H2&+0&D1:1]>>[C&H3&+0&D1:3]-[N&H1&+0&D2:1]-[C:2]|[CH3:1]I.[NH2:2][CH:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[CH:10]1[CH2:11][CH2:12][N:13]1[CH:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>CN(C)C=O.[NaH]>[CH3:1][NH:2][CH:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[CH:10]1[CH2:11][CH2:12][N:13]1[CH:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1|US20200181104A1_0448
2.6.3|[C&H3&+0&D1:3]-O.[C:2]-[O&H1&+0&D1:1]>>[C&H3&+0&D1:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1]O.[CH3:2][CH:3]([C:4](=[O:5])[OH:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[F:19])[F:20]>O=S(=O)(O)O>[CH3:2][CH:3]([C:4](=[O:5])[O:6][CH3:1])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[F:19])[F:20]|EP3134408B1_0289
1.2.1|[N&H3&+0&D0:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|[NH3:1].[CH3:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH:22]=O>CCO.[H][H].[Ni]>[CH3:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][O:15][c:14]1[cH:13][c:12]([cH:11][cH:10][c:9]1[O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH3:2])[CH2:22][NH2:1]|EP2188254B1_0102
7.9.20|[C:4]-[P&H0&+0&D4:3](-[c:2])(-[c:1])=O>>[C:4]-[P&H0&+0&D3:3](-[c:2])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[CH2:14][P:15](=O)([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[CH2:14][P:15]([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|EP0795559B1_0037
9.7.334|[C:2]-[N&H1&+0&D2:1]-[C@&H1](-C)-c1:c:c:c(-O-C):c:c:1>>[C:2]-[N&H2&+0&D1:1]|COc1ccc(cc1)[C@@H](C)[NH:1][C:2](=[O:3])[C@H:4]1[C@@H:5]2[CH:6]=[CH:7][C@@H:8]([CH2:9]2)[C@H:10]1[NH:11][c:12]1[n:13][c:14]([n:15][cH:16][c:17]1[F:18])[Cl:19]>O.N#CC1=C(C(C(=C(C1=O)Cl)Cl)=O)C#N.ClCCl>[NH2:1][C:2](=[O:3])[C@H:4]1[C@@H:5]2[CH:6]=[CH:7][C@@H:8]([CH2:9]2)[C@H:10]1[NH:11][c:12]1[n:13][c:14]([n:15][cH:16][c:17]1[F:18])[Cl:19]|US10077276B2_0470
9.7.39|[N&H3&+0&D0:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[CH2:8]Cl)[Cl:9].[NH3:10]>c1ccccc1>[NH2:10][CH2:8][c:7]1[c:2]([cH:3][cH:4][cH:5][c:6]1[Cl:9])[F:1]|US20090069336A1_0205
9.7.39|[N&H3&+0&D0:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[NH3:1].[CH3:2][C:3]([CH3:4])([NH:5][C:6](=[O:7])[CH2:8]Cl)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>CCO>[CH3:2][C:3]([CH3:4])([NH:5][C:6](=[O:7])[CH2:8][NH2:1])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US20090246169A1_1080
9.7.253|[O:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-Br>>[O:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[N:7][O:8][CH2:9][CH2:10]Br)[C:11]1([O:12][CH2:13][CH2:14][O:15]1)[CH3:16]>O.O.CS(C)=O.CC(C)(C)[O-].C1CCOC1.[K+]>[CH2:10]=[CH:9][O:8][N:7]=[C:6]([C:4](=[O:5])[O:3][CH2:2][CH3:1])[C:11]1([O:12][CH2:13][CH2:14][O:15]1)[CH3:16]|US20170327469A1_0420
9.7.254|[S:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-Cl>>[S:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[CH3:1][c:2]1[cH:3][c:4]([n:5][c:6]([n:7]1)[NH:8][C:9](=[O:10])[NH:11][S:12](=[O:13])(=[O:14])[CH2:15][CH2:16]Cl)[CH3:17]>O.CCO.O[Na]>[CH2:16]=[CH:15][S:12](=[O:13])(=[O:14])[NH:11][C:9](=[O:10])[NH:8][c:6]1[n:5][c:4]([cH:3][c:2]([n:7]1)[CH3:1])[CH3:17]|US04088495A
9.7.59|[C:4]-[C&H0&+0&D4:3](-[C:2])(-[c:1])-Cl>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](Cl)([c:7]1[cH:8][n:9][c:10]([n:11][cH:12]1)[C:13]([CH3:14])([CH3:15])[CH3:16])[C:17]([CH3:18])([CH3:19])[CH3:20]>CCCC[SnH](CCCC)CCCC.CC(C)(C#N)N=NC(C)(C)C#N.Cc1ccccc1.O>[CH3:14][C:13]([CH3:15])([CH3:16])[c:10]1[n:9][cH:8][c:7]([cH:12][n:11]1)[CH:6]([C:4](=[O:5])[O:3][CH2:2][CH3:1])[C:17]([CH3:18])([CH3:19])[CH3:20]|US20090131708A1_0025
9.7.22|[N&H3&+0&D0:3].[c:2]-[C&H2&+0&D2:1]-Br>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|[NH3:1].[CH3:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[S:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16]Br>O.CO>[CH3:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[S:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][NH2:1]|US20110201656A1_0104
9.7.44|[O&H2&+0&D0:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[O&H1&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|[OH2:1].[O:2]=[C:3]([OH:4])[CH2:5][CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH2:13]Cl>O=C(O)c1ccccc1C(c1ccc(cc1)O)c1ccc(cc1)O.O[Na]>[O:2]=[C:3]([OH:4])[CH2:5][CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH2:13][OH:1]|EP3511002B1_0283
9.7.27|[O&H2&+0&D0:3].[c:2]-[C&H2&+0&D2:1]-Br>>[O&H1&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|[OH2:1].[Cl:2][C:3]([Cl:4])=[CH:5][O:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[CH2:13]Br>[Na+].CO.Cc1ccccc1.Cc1ccc(cc1)S([O-])(=O)=O>[OH:1][CH2:13][c:11]1[cH:10][cH:9][cH:8][c:7]([cH:12]1)[O:6][CH:5]=[C:3]([Cl:2])[Cl:4]|US20200369675A1_0214
9.7.253|[c:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-Br>>[c:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[CH3:1][S:2](=[O:3])(=[O:4])[NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][C:13](=[O:14])[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[CH2:21][CH2:22]Br>CC(C)=O.O=C(O[K])O[K]>[CH2:22]=[CH:21][c:18]1[cH:19][cH:20][c:15]([cH:16][cH:17]1)[C:13](=[O:14])[O:12][c:9]1[cH:10][cH:11][c:6]([cH:7][cH:8]1)[NH:5][S:2]([CH3:1])(=[O:3])=[O:4]|US09505713B2_0011
9.7.254|[C:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-Cl>>[C:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[O:1]=[C:2]([CH2:3][CH2:4]Cl)[N:5]1[c:6]2[n:7][cH:8][cH:9][cH:10][c:11]2[NH:12][C:13]([c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21)=[O:20]>CCN(CC)CC.C1COCCO1>[CH2:4]=[CH:3][C:2](=[O:1])[N:5]1[c:19]2[cH:18][cH:17][cH:16][cH:15][c:14]2[C:13]([NH:12][c:11]2[cH:10][cH:9][cH:8][n:7][c:6]21)=[O:20]|US07307107B2_0147
9.7.22|[N&H3&+0&D0:3].[C:2]-[C&H2&+0&D2:1]-Br>>[N&H2&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5][CH2:6][CH:7]([CH3:8])[CH2:9][CH:10]=[CH:11][C:12]([CH3:13])=[CH:14][CH2:15]Br.[NH3:16]>c1ccccc1>[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5][CH2:6][CH:7]([CH3:8])[CH2:9][CH:10]=[CH:11][C:12]([CH3:13])=[CH:14][CH2:15][NH2:16]|US20200377469A1_0487
9.7.254|[n:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-Cl>>[n:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[c:8]1[n:9][cH:10][c:11]2[c:12]([c:13]([cH:14][n:15]([c:16]2[n:17]1)[CH2:18][CH2:19]Cl)[C:20](=[O:21])[OH:22])=[O:23]>Cl.O[Na]>[CH2:19]=[CH:18][n:15]1[cH:14][c:13]([c:12]([c:11]2[cH:10][n:9][c:8]([n:17][c:16]21)[N:5]1[CH2:6][CH2:7][N:2]([CH2:3][CH2:4]1)[CH3:1])=[O:23])[C:20](=[O:21])[OH:22]|US20130303533A1_1122
9.7.27|[O&H2&+0&D0:3].[C:2]-[C&H2&+0&D2:1]-Br>>[O&H1&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[OH2:1].[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[n:11][c:12]([s:13][c:14]1-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[O:21][CH3:22])[S:23][CH2:24][CH2:25]Br>O[K]>[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[n:11][c:12]([s:13][c:14]1-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[O:21][CH3:22])[S:23][CH2:24][CH2:25][OH:1]|EP3730135A1_0132
9.7.254|[O:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-Cl>>[O:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH2:10][CH2:11]Cl)[CH:12]=[CH:13][C:14](=[O:15])[NH:16][C@@H:17]1[CH2:18][CH2:19][C@H:20]([CH2:21][CH2:22]1)[CH3:23]>C1CCOC1.Cl.[NaH]>[CH2:11]=[CH:10][O:9][c:8]1[cH:7][cH:6][c:5]([cH:4][c:3]1[O:2][CH3:1])[CH:12]=[CH:13][C:14](=[O:15])[NH:16][C@H:17]1[CH2:18][CH2:19][C@@H:20]([CH2:21][CH2:22]1)[CH3:23]|US08450319B2_1874
9.7.139|[C:4]-[C&H0&+0&D4:3](-[C:2])(-[C:1])-Br>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][CH:2]([OH:3])[C:4]1([C:5]([N:6]2[C@H:7]([C:8]([S:9][C@@H:10]21)([CH3:11])[CH3:12])[C:13](=[O:14])[O:15][CH3:16])=[O:17])Br>CCO.[Pd]>[CH3:16][O:15][C:13](=[O:14])[C@@H:7]1[N:6]2[C:5]([CH:4]([C@H:10]2[S:9][C:8]1([CH3:11])[CH3:12])[CH:2]([CH3:1])[OH:3])=[O:17]|US10822229B2_0163
9.7.253|[C:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-Br>>[C:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[CH3:1][N+:2]([CH3:3])([CH3:4])[CH2:5][C:6]([OH:7])([CH2:8][C:9]([O-:10])=[O:11])[C:12](=[O:13])[CH2:14][CH2:15]Br>O>[CH2:15]=[CH:14][C:12](=[O:13])[C:6]([OH:7])([CH2:8][C:9]([O-:10])=[O:11])[CH2:5][N+:2]([CH3:1])([CH3:3])[CH3:4]|US08552242B2_0445
9.7.44|[O&H2&+0&D0:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[O&H1&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[OH2:1].[CH3:2][CH:3]([CH3:4])[O:5][CH2:6][CH2:7][CH:8]=[CH:9][CH2:10]Cl>O=C(O[Na])O[Na]>[CH3:2][CH:3]([CH3:4])[O:5][CH2:6][CH2:7][CH:8]=[CH:9][CH2:10][OH:1]|EP0688763B1_0032
9.5.1|[C:3]-[C&H0&+0&D3:2](-[N&H2&+0&D1:1])=O>>[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]|[NH2:1][C:2](=O)[CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1>O=S(Cl)Cl>[N:1]#[C:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1|US10561657B2_0415
9.1.5|[Br&H1&+0&D0:3].[C:2]-[C&H2&+0&D2:1]-O>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[BrH:1].[CH3:2][CH:3]([CH3:4])[CH2:5][CH2:6][CH2:7][CH:8]([CH3:9])[CH2:10][CH2:11][CH2:12][CH:13]([CH3:14])[CH2:15]O>>[CH3:2][CH:3]([CH3:4])[CH2:5][CH2:6][CH2:7][CH:8]([CH3:9])[CH2:10][CH2:11][CH2:12][CH:13]([CH3:14])[CH2:15][Br:1]|US06492406B1
9.5.1|[N&H2&+0&D1:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][n:3]1[c:4]([n:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]21)[C:12]([NH2:13])=O)[CH3:14]>O.O.O=P(Cl)(Cl)Cl.c1ccncc1>[CH3:1][CH2:2][n:3]1[c:4]([n:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]21)[C:12]#[N:13])[CH3:14]|US09790201B2_0538
3.11.91|[C&H3&+0&D1:3]-[C:2].[C&H3&+0&D1:1]-I>>[C&H2&+0&D2:3](-[C&H3&+0&D1:1])-[C:2]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[s:6][c:7]2[CH2:8][CH2:9][CH2:10][CH2:11][c:12]2[c:13]1[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[CH3:22]I>O.CN(C)C=O.[NaH]>[CH3:22][CH2:1][C:2](=[O:3])[NH:4][c:5]1[s:6][c:7]2[CH2:8][CH2:9][CH2:10][CH2:11][c:12]2[c:13]1[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US10647665B2_0216
9.5.4|[C&H3&+0&D1:3]-[C&H1&+0&D3:2](-[c:1])-O>>[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])[O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH:16]([CH3:17])O>O.Cc1ccc(cc1)S(=O)(=O)Cl.c1ccncc1>[CH2:17]=[CH:16][c:13]1[cH:14][cH:15][c:10]([cH:11][cH:12]1)[O:9][C:6]([CH3:7])([CH3:8])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US07820848B2_0031
9.7.194|[C:3]-[C&H1&+0&D3:2](-[N&H2&D1:1])-C(=O)-O>>[C:3]-[C&H2&+0&D2:2]-[N&H2&D1:1]|[NH2:1][CH:2]([CH2:3][c:4]1[cH:5][nH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21)C(=O)O>>[NH2:1][CH2:2][CH2:3][c:4]1[cH:5][nH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21|US06465474B1
9.1.5|[Br&H1&+0&D0:3].[c:2]-[C&H2&+0&D2:1]-O>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|[BrH:1].O[CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[C:9]([F:10])([F:11])[C:12]([F:13])([F:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>>[F:13][C:12]([F:14])([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[C:9]([F:10])([F:11])[c:8]1[cH:7][cH:6][cH:5][cH:4][c:3]1[CH2:2][Br:1]|US05707936A
10.1.4|[C&H1&+0&D1:3]#[C:2].[I&H0&+0&D1:1]-I>>[C&H0&+0&D2:3](#[C:2])-[I&H0&+0&D1:1]|[CH:1]#[C:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][n:9][cH:10]1.[I:11]I>O.CO.O[Na]>[I:11][C:1]#[C:2][CH2:3][O:4][c:5]1[cH:10][n:9][cH:8][cH:7][cH:6]1|EP0057207B1_0047
9.5.4|[C&H3&+0&D1:3]-[C&H1&+0&D3:2](-[C:1])-O>>[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)[CH:12]([CH3:13])O>O=P12OP3(OP(O2)(OP(O1)(O3)=O)=O)=O.c1ccccc1>[CH2:13]=[CH:12][C:6]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20200216403A1_0518
4.2.35|[O&H1&+0&D1:3]-[C:2]-[C&H2&+0&D2:1]-O>>[O&H0&+0&D2:3]1-[C&H2&+0&D2:1]-[C:2]-1|[CH3:1][C:2]([CH3:3])=[N:4][NH:5][c:6]1[cH:7][cH:8][c:9]([n:10][n:11]1)[O:12][CH2:13][CH:14]([OH:15])[CH2:16]O.Cl>CC(C)OC(C)C.CC(=O)O.Br>[CH3:1][C:2]([CH3:3])=[N:4][NH:5][c:6]1[cH:7][cH:8][c:9]([n:10][n:11]1)[O:12][CH2:13][CH:14]1[CH2:16][O:15]1|US09126950B2_0450
10.1.1|[Br&H0&+0&D1:3]-Br.[C&H3&+0&D1:2]-[C:1]>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[C:11]([CH3:12])=[O:13].[Br:14]Br>ClC(Cl)Cl>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[C:11](=[O:13])[CH2:12][Br:14]|EP2870156B1_0358
10.1.1|[Br&H0&+0&D1:3]-Br.[C&H3&+0&D1:2]-[c:1]>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][n+:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[n+:11]1[O-:12])[O-:13].[Br:14]Br>CO>[O-:13][n+:4]1[cH:3][c:2]([n+:11]([c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]21)[O-:12])[CH2:1][Br:14]|US20140080821A1_0450
10.1.1|[Br&H0&+0&D1:3]-Br.[C&H1&+0&D1:2]#[C:1]>>[Br&H0&+0&D1:3]-[C&H0&+0&D2:2]#[C:1]|[CH:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[Br:15]Br>O.CCCCCC.CCOCC.CCCC[Li]>[CH3:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]#[C:1][Br:15]|US09549916B2_0517
4.2.35|[O&H1&+0&D1:3]-[C:2]-[C&H2&+0&D2:1]-Br>>[O&H0&+0&D2:3]1-[C&H2&+0&D2:1]-[C:2]-1|[O:1]=[c:2]1[n:3][cH:4][c:5]([cH:6][n:7]1[CH2:8][CH:9]([OH:10])[CH2:11]Br)[Cl:12]>C1CCOC1>[O:1]=[c:2]1[n:3][cH:4][c:5]([cH:6][n:7]1[CH2:8][CH:9]1[CH2:11][O:10]1)[Cl:12]|US20200268688A1_0548
7.4.2|[O&H0&+0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O-C>>[O&H1&+0&D1:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[cH:15]1)[C:16](=[O:17])OC>O.CO.O[Na]>[CH3:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[cH:15]1)[CH2:16][OH:17]|US07429605B2_0607
8.1.18|[C:3]-[C&H1&+0&D3:2](-[O&H1&+0&D1:1])-C-O>>[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]|[CH3:1][O:2][C:3]([CH3:4])([CH3:5])[CH2:6][CH2:7][CH2:8][CH:9]([CH3:10])[CH:11]([OH:12])CO>O.O=C(O)O[Na].O=[I](=O)(=O)O>[CH3:1][O:2][C:3]([CH3:4])([CH3:5])[CH2:6][CH2:7][CH2:8][CH:9]([CH3:10])[CH:11]=[O:12]|EP0342664B1_0175
7.4.1|[C:3]-[C&H0&+0&D3:2](=[O&H0&+0&D1:1])-O-C>>[C:3]-[C&H2&+0&D2:2]-[O&H1&+0&D1:1]|CO[C:1](=[O:2])[C:3]1=[C:4]([CH:5]=[C:6]([CH2:7][C:8]1([CH3:9])[CH3:10])[O:11][CH2:12][CH3:13])[CH3:14]>CCOCC.[Li][AlH4]>[CH3:13][CH2:12][O:11][C:6]1=[CH:5][C:4](=[C:3]([C:8]([CH2:7]1)([CH3:9])[CH3:10])[CH2:1][OH:2])[CH3:14]|US04564694A
4.2.35|[O&H1&+0&D1:3]-[C:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:3]1-[C&H2&+0&D2:1]-[C:2]-1|[NH2:1][C:2](=[O:3])[C:4]([OH:5])([CH2:6][C:7](=[O:8])[OH:9])[CH2:10]Cl>>[NH2:1][C:2](=[O:3])[C:4]1([CH2:10][O:5]1)[CH2:6][C:7](=[O:8])[OH:9]|US20050244460A1_0087
9.7.60|[C:3]-[C&H1&+0&D3:2](-[O&H0&+0&D2:1]-C)-O>>[C:3]-[C&H2&+0&D2:2]-[O&H1&+0&D1:1]|C[O:1][CH:2](O)[C@@H:3]1[CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[C:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>C1CCOC1.[Li+].[AlH4-]>[OH:1][CH2:2][C@@H:3]1[CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[C:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|EP0073451B1_0200
9.7.60|[c:3]-[C&H1&+0&D3:2](-[O&H0&+0&D2:1]-C)-O>>[c:3]-[C&H2&+0&D2:2]-[O&H1&+0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[c:15]2[cH:16][c:17]([cH:18][cH:19][c:20]21)[CH:21](O)[O:22]C>>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[c:15]2[cH:16][c:17]([cH:18][cH:19][c:20]21)[CH2:21][OH:22]|US20170216293A1_0946
6.5.9|[C:3]-[C&H1&+0&D3:2](-[O&H0&+0&D2:1]-C)-O-C>>[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]|C[O:1][CH:2]([CH2:3][CH:4]([CH3:5])[CH2:6][CH2:7][CH2:8][C:9]([CH3:10])([CH3:11])[S:12][CH3:13])OC>Cl.C1CCOC1>[CH3:13][S:12][C:9]([CH3:10])([CH3:11])[CH2:8][CH2:7][CH2:6][CH:4]([CH3:5])[CH2:3][CH:2]=[O:1]|US20170276671A1_0084
9.7.55|[c:3]-[C&H1&+0&D2:2]=[C&H0&+0&D3:1](-Br)-Br>>[c:3]-[C&H0&+0&D2:2]#[C&H1&+0&D1:1]|[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]=[C:10](Br)Br>O.CCCCCC.CCCC[Li].C1CCOC1>[CH:10]#[C:9][c:6]1[cH:7][cH:8][c:3]([cH:4][cH:5]1)[CH2:2][CH3:1]|US20040209897A1_1448
1.1.1|[C&H3&+0&D1:3]-B(-O)-O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&+0&D1:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[Cl:8])[NH2:9].[CH3:10]B(O)O>c1ccncc1.C1COCCO1>[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[Cl:8])[NH:9][CH3:10]|US10414747B2_0574
9.7.94|[B:3](-[O&H0&+0&D2:2]-C)-[O&H0&+0&D2:1]-C>>[B:3](-[O&H1&+0&D1:2])-[O&H1&+0&D1:1]|C[O:1][B:2]([O:3]C)[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[O:10][CH:11]1[CH2:12][CH2:13]1>O.Cl>[OH:3][B:2]([OH:1])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[O:10][CH:11]1[CH2:12][CH2:13]1|US05294716A
9.7.194|[c:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-C(-O)=O>>[c:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[n:14]1[c:15]([n:16][c:17]2[c:18]1[cH:19][c:20]([cH:21][cH:22]2)[C:23](C(=O)O)([c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[Cl:30])[c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[Cl:37])[CH:38]1[CH2:39][CH2:40]1>C1CN=C2CCCCCN2C1.Cc1ccccc1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[n:14]1[c:15]([n:16][c:17]2[c:18]1[cH:19][c:20]([cH:21][cH:22]2)[CH:23]([c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[Cl:30])[c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[Cl:37])[CH:38]1[CH2:39][CH2:40]1|US03963732A
6.5.9|[c:3]-[C&H1&+0&D3:2](-[O&H0&+0&D2:1]-C)-O-C>>[c:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]|C[O:1][CH:2](OC)[c:3]1[cH:4][c:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[o:12]1)=[O:13]>Cl>[O:13]=[c:5]1[cH:4][c:3]([o:12][c:11]2[cH:10][cH:9][cH:8][cH:7][c:6]21)[CH:2]=[O:1]|US04112112A
9.7.55|[C:3]-[C&H1&+0&D2:2]=[C&H0&+0&D3:1](-Br)-Br>>[C:3]-[C&H0&+0&D2:2]#[C&H1&+0&D1:1]|[CH3:1][O:2][C:3](=[O:4])[C@@H:5]1[C@@H:6]([C:7]1([CH3:8])[CH3:9])[CH:10]=[C:11](Br)Br>C1CCCCC1.CCCC[Li].[O-]P(=O)(O)O.[Na+]>[CH:11]#[C:10][C@H:6]1[C@H:5]([C:7]1([CH3:8])[CH3:9])[C:3](=[O:4])[O:2][CH3:1]|US20160137639A1_3249
9.1.5|[Br&H0&+0&D1:3]-[#3].[c:2]-[C&H2&+0&D2:1]-O>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][c:16]1[cH:17][cH:18][cH:19][c:20]([cH:21]1)[CH2:22][C:23](=[O:24])[NH:25][c:26]1[cH:27][cH:28][cH:29][c:30]([cH:31]1)[CH2:32]O.[Br:33][Li]>CCN(CC)CC.CS(=O)(=O)Cl.O=C(O)O[Na].C1CCOC1.Cl[Na]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][c:16]1[cH:17][cH:18][cH:19][c:20]([cH:21]1)[CH2:22][C:23](=[O:24])[NH:25][c:26]1[cH:27][cH:28][cH:29][c:30]([cH:31]1)[CH2:32][Br:33]|US09175031B2_0463
9.7.252|[c:3]-[C&H1&+0&D3:2](-[c:1])-S(=O)(=O)-c1:c:c:c:c:c:1>>[c:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][n:2]1[c:3]2[c:4]([nH:5][n:6][cH:7][c:8]2[c:9]2[s:10][c:11]([n:12][c:13]21)[CH:14]([c:15]1[cH:16][cH:17][n:18][n:19]1[CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:25])([CH3:26])[CH3:27])S(=O)(=O)c1ccccc1)=[O:28]>C1CCOC1.I[Sm]I.CO>[CH3:1][n:2]1[c:3]2[c:4]([nH:5][n:6][cH:7][c:8]2[c:9]2[s:10][c:11]([n:12][c:13]21)[CH2:14][c:15]1[cH:16][cH:17][n:18][n:19]1[CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:25])([CH3:26])[CH3:27])=[O:28]|US20200207785A1_0230
6.1.20|[S:3]-[N&H0&+0&D3:2](-[c:1])-S(=O)(=O)-c1:c:c:c:c:c:1>>[S:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][o:7][c:8]([c:9]1[Br:10])[N:11]([S:12](=[O:13])(=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)S(=O)(=O)c1ccccc1>CO.O[Na]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][o:7][c:8]([c:9]1[Br:10])[NH:11][S:12](=[O:13])(=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20160168132A1_0299
6.1.20|[C:3]-[N&H0&+0&D3:2](-[c:1])-S(=O)(=O)-c1:c:c:c:c:c:1>>[C:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[CH2:9][CH2:10][N:11]2S(=O)(=O)c1ccccc1>[Na+].Br.[OH-]>[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]2[NH:11][CH2:10][CH2:9][c:7]2[cH:8]1|US20200172546A1_1256
6.1.20|[C:3]-[N&H0&+0&D3:2](-[C:1])-S(=O)(=O)-c1:c:c:c:c:c:1>>[C:3]-[N&H1&+0&D2:2]-[C:1]|O=S(=O)(c1ccccc1)[N:1]1[CH2:2][CH:3]2[CH2:4][N:5]([CH2:6][CH:7]([CH2:8]1)[O:9]2)[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O.O[K].C1CCOC1.[Li][AlH4]>[cH:14]1[cH:15][cH:16][c:11]([cH:12][cH:13]1)[CH2:10][N:5]1[CH2:6][CH:7]2[CH2:8][NH:1][CH2:2][CH:3]([CH2:4]1)[O:9]2|US20200384450A1_0206
9.1.5|[Br&H0&+0&D1:3]-[#3].[C:2]-[C&H2&+0&D2:1]-O>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])[O:4][CH:5]1[CH2:6][CH2:7][CH2:8][C:9]2([C:10](=[CH:11][CH2:12][CH:13]12)[CH:14]([CH3:15])[CH2:16][CH:17]([Cl:18])[CH2:19]O)[CH3:20].[Br:21][Li]>O.Cc1ccc(cc1)S(=O)(=O)Cl.ClCCl.c1ccncc1>[CH3:1][C:2](=[O:3])[O:4][CH:5]1[CH2:6][CH2:7][CH2:8][C:9]2([C:10](=[CH:11][CH2:12][CH:13]12)[CH:14]([CH3:15])[CH2:16][CH:17]([Cl:18])[CH2:19][Br:21])[CH3:20]|US07071175B1_0331
6.1.3|[C:3]-[N&H0&+0&D3:2](-[N:1])-C(=O)-O-C-c1:c:c:c:c:c:1>>[C:3]-[N&H1&+0&D2:2]-[N:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH:8]1[CH2:9][C:10](=[N:11][N:12]1C(=O)OCc1ccccc1)[c:13]1[cH:14][cH:15][cH:16][s:17]1>CCO.[H][H].[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH:8]1[CH2:9][C:10](=[N:11][NH:12]1)[c:13]1[cH:14][cH:15][cH:16][s:17]1|US20200131192A1_0177
6.1.20|[c:3]:[n&H0&+0&D3:2](:[n:1])-S(=O)(=O)-c1:c:c:c:c:c:1>>[c:3]:[n&H1&+0&D2:2]:[n:1]|[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[c:8]1[n:9][n:10]([c:11]2[cH:12][cH:13][c:14]([cH:15][c:16]12)[Br:17])S(=O)(=O)c1ccccc1>O.C1CCOC1.[Li][AlH4]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[c:8]1[n:9][nH:10][c:11]2[cH:12][cH:13][c:14]([cH:15][c:16]12)[Br:17]|US08163743B2_1102
6.1.20|[c:3]:[n&H0&+0&D3:2](:[c:1])-S(=O)(=O)-c1:c:c:c:c:c:1>>[c:3]:[n&H1&+0&D2:2]:[c:1]|[CH3:1][C:2](=[O:3])[CH:4]1[CH2:5][N:6]([CH:7]2[CH2:8][c:9]3[cH:10][n:11]([c:12]4[cH:13][cH:14][cH:15][c:16]([c:17]34)[CH:18]12)S(=O)(=O)c1ccccc1)[CH3:19]>CCO.O[K]>[CH3:1][C:2](=[O:3])[CH:4]1[CH2:5][N:6]([CH:7]2[CH2:8][c:9]3[cH:10][nH:11][c:12]4[cH:13][cH:14][cH:15][c:16]([c:17]34)[CH:18]12)[CH3:19]|US08987319B2_0270
8.8.14|[C&H3&+0&D1:3]-[c:2].[O&H0&+0&D1:1]=[#34]=O>>[C&H1&+0&D2:3](=[O&H0&+0&D1:1])-[c:2]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.O=[Se]=[O:15]>>[O:15]=[CH:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[O:8][c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1|EP2880028B1_0546
8.8.14|[C&H3&+0&D1:3]-[C:2].[O&H0&+0&D1:1]=[#34]=O>>[C&H1&+0&D2:3](-[C:2])=[O&H0&+0&D1:1]|[CH3:1][C:2](=[O:3])[C:4]1=[CH:5][CH:6]=[C:7]2[C:8](=[CH:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]23)[C:16]1=[O:17].O=[Se]=[O:18]>C1COCCO1>[O:17]=[C:16]1[C:8]2=[CH:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[C:7]2=[CH:6][CH:5]=[C:4]1[C:2](=[O:3])[CH:1]=[O:18]|EP2531492B1_0190
9.7.194|[C:4]-[C&H0&+0&D4:3]1(-[C:2]-[C:1]-1)-C(-O)=O>>[C:4]-[C&H1&+0&D3:3]1-[C:2]-[C:1]-1|[CH3:1][C:2]1([CH:3]([C:4]1([C:5]#[N:6])C(=O)O)[CH:7]=[C:8]([Cl:9])[Cl:10])[CH3:11]>N.O.CN(C)C=O>[CH3:1][C:2]1([CH:4]([CH:3]1[CH:7]=[C:8]([Cl:9])[Cl:10])[C:5]#[N:6])[CH3:11]|US09790211B2_0324
9.7.334|[C:3]-[N&H0&+0&D3:2](-[C:1])-[C@&H1](-C)-c1:c:c:c:c:c:1>>[C:3]-[N&H1&+0&D2:2]-[C:1]|[CH3:1][C:2](=[O:3])[O:4][CH:5]1[CH2:6][N:7]([CH2:8][C:9]11[CH2:10][CH2:11]1)[C@H](C)c1ccccc1>CCO.[H][H].[Pd]>[CH3:1][C:2](=[O:3])[O:4][CH:5]1[CH2:6][NH:7][CH2:8][C:9]11[CH2:10][CH2:11]1|US09376441B2_2075
8.8.18|[c:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]>>[c:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]|[O:1]=[CH:2][c:3]1[c:4]2[CH2:5][CH2:6][c:7]3[cH:8][cH:9][cH:10][c:11]([c:12]4[cH:13][cH:14][cH:15][cH:16][c:17]14)[c:18]32>CCCCCC.Cc1ccccc1>[O:1]=[CH:2][c:3]1[c:17]2[cH:16][cH:15][cH:14][cH:13][c:12]2[c:11]2[cH:10][cH:9][cH:8][c:7]3[CH:6]=[CH:5][c:4]1[c:18]32|US10556907B2_0800
7.9.8|[C:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[c:1]>>[C:4]/[C&H1&+0&D2:3]=[C&H1&+0&D2:2]/[c:1]|[OH:1][CH2:2][CH2:3][C:4]#[C:5][c:6]1[cH:7][n:8][cH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21>CCO.[Pd]>[OH:1][CH2:2][CH2:3]/[CH:4]=[CH:5]/[c:6]1[cH:7][n:8][cH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21|EP1894911A1_0977
7.6.1|[N:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[N:1]>>[N:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[N:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]=[CH:10][N:11]([C:12]([C@@H:13]1[CH2:14][O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:23])[CH2:24][c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)-[n:31]1[cH:32][cH:33][n:34][cH:35]1>CCO.[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([C:12]([C@@H:13]1[CH2:14][O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:23])[CH2:24][c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)-[n:31]1[cH:35][n:34][cH:33][cH:32]1|US20180244648A1_0234
7.3.4|[N:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[N:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[NH:10][N:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[Cl:19]>Nc1c(cc(c2ccccc12)S(=O)(=O)O)N=Nc1ccc(cc1)-c1ccc(cc1)N=Nc1cc(c2ccccc2c1N)S(=O)(=O)O.C1CCOC1.N#C[BH3-].CO.O.[Na+].Cl>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[NH:10][NH:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[Cl:19]|EP3640253A1_0606
7.9.8|[C:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[c:1]>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]|[CH2:1]=[CH:2][CH2:3][O:4][c:5]1[cH:6][c:7]([c:8]([c:9]([c:10]1[CH3:11])[CH3:12])[C:13]#[C:14][C:15]([CH3:16])([OH:17])[CH:18]=[CH2:19])[CH3:20]>>[CH2:1]=[CH:2][CH2:3][O:4][c:5]1[cH:6][c:7]([c:8]([c:9]([c:10]1[CH3:11])[CH3:12])[CH:13]=[CH:14][C:15]([CH3:16])([OH:17])[CH:18]=[CH2:19])[CH3:20]|US06417366B2
7.6.1|[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[O:1]>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[O:1]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][CH2:6][CH:7]=[CH:8][O:9][C:10]([CH3:11])=[O:12]>>[CH3:11][C:10](=[O:12])[O:9][CH2:8][CH2:7][CH2:6][CH2:5][O:4][C:2]([CH3:1])=[O:3]|US04007209A
7.6.1|[c:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[c:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH:6]=[C:7]1[c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[CH:14]=[CH:15][c:16]2[cH:17][cH:18][c:19]([cH:20][c:21]12)[S:22]([CH3:23])(=[O:24])=[O:25]>CCO.[Ni]>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH:6]=[C:7]1[c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[CH2:14][CH2:15][c:16]2[cH:17][cH:18][c:19]([cH:20][c:21]12)[S:22]([CH3:23])(=[O:24])=[O:25]|US07462630B2_0529
7.3.4|[c:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[n:1]>>[c:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH:16]=[N:17][n:18]1[cH:19][cH:20][n:21][cH:22]1>CC(=O)O.N#C[BH3-].[Na+]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:16][NH:17][n:18]1[cH:19][cH:20][n:21][cH:22]1|US08912330B2_0434
7.6.1|[c:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[n:1]>>[c:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[n:1]|[O:1]=[c:2]1[nH:3][n:4][c:5]2[CH2:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[CH:13]=[CH:14][n:15]21>CC(=O)O.[Pd]>[O:1]=[c:2]1[nH:3][n:4][c:5]2[CH2:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[CH2:13][CH2:14][n:15]12|US09063126B2_0844
7.3.4|[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][n:10]1)[N:11]=[CH:12][CH:13]=[CH:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O.[Na+].Cl.CO.CC(=O)O.CN(C)C=O.[BH4-].[BH4-]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][n:10]1)[NH:11][CH2:12][CH:13]=[CH:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20110086834A1_0597
7.6.1|[N:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[N:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][C:7]([NH:8][CH:9]=[CH:10][c:11]2[cH:12][c:13]1[O:14][CH3:15])=[O:16]>CC(=O)O.[H][H].[Pd]>[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][C:7]([NH:8][CH2:9][CH2:10][c:11]2[cH:12][c:13]1[O:14][CH3:15])=[O:16]|US08097720B2_0077
1.7.2|[C&H2&+0&D1:3]=[N&+]=[N&-].[C:2]-[O&H1&+0&D1:1]>>[C&H3&+0&D1:3]-[O&H0&+0&D2:1]-[C:2]|[CH2:1]=[N+]=[N-].[O:2]=[C:3]([OH:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:12]([CH2:13][CH:14]([C:15]=1[CH:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[OH:24])=[N:25][OH:26]>O.COCCOC.CC(=O)O.NC(=O)NCN=O.O[K]>[CH3:1][O:4][C:3](=[O:2])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:12]([CH2:13][CH:14]([C:15]=1[CH:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[OH:24])=[N:25][OH:26]|EP3656770A2_0126
7.3.4|[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[n:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[n:1]|[CH3:1][CH2:2][CH:3]=[N:4][n:5]1[cH:6][cH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]21>O.[Na+].CC(=O)O.CN1CCCC1=O.[H][H].[BH4-]>[CH3:1][CH2:2][CH2:3][NH:4][n:5]1[cH:6][cH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]21|US07902203B2_1460
7.3.4|[S:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[S:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([c:8]2[O:9][S:10]([N:11]=[CH:12][c:13]2[cH:14]1)(=[O:15])=[O:16])[I:17]>CO.[Na+].[BH4-]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([c:8]2[O:9][S:10]([NH:11][CH2:12][c:13]2[cH:14]1)(=[O:15])=[O:16])[I:17]|US10030047B2_0866
1.8.8|[C:4]-[S&H1&+0&D1:3].[S&H1&+0&D1:2]-[c:1]>>[C:4]-[S&H0&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][SH:6].[SH:7][c:8]1[cH:9][cH:10][cH:11][cH:12][n:13]1>COC(=O)SCl.ClCCl>[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][S:6][S:7][c:8]1[cH:9][cH:10][cH:11][cH:12][n:13]1|EP3458101B1_0362
7.9.8|[c:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[c:1]>>[c:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][N:2]1[C:3]([CH2:4][CH2:5][C@@:6]2([c:7]3[cH:8][cH:9][c:10]([cH:11][c:12]3[CH2:13][CH2:14][C@@H:15]12)[C:16]#[C:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH3:24])=[O:25]>c1ccncc1.[H][H].[Pd]>[CH3:1][N:2]1[C:3]([CH2:4][CH2:5][C@@:6]2([c:7]3[cH:8][cH:9][c:10]([cH:11][c:12]3[CH2:13][CH2:14][C@@H:15]12)[CH:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH3:24])=[O:25]|US09840497B2_0533
7.6.1|[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[O:1]=[C:2]([OH:3])[CH:4]=[CH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18]>CCO.[H][H].[O-2].[Pt+2]>[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18]|EP0535250A1_0258
1.8.8|[C:4]-[S&H1&+0&D1:3].[C:2]-[S&H1&+0&D1:1]>>[C:4]-[S&H0&+0&D2:3]-[S&H0&+0&D2:1]-[C:2]|Cl.[CH3:1][NH:2][C:3](=[N:4][CH2:5][CH2:6][SH:7])[NH:8][C:9]#[N:10].[CH3:11][c:12]1[nH:13][cH:14][n:15][c:16]1[CH2:17][SH:18]>O[Na].II>[CH3:1][NH:2][C:3](=[N:4][CH2:5][CH2:6][S:7][S:18][CH2:17][c:16]1[n:15][cH:14][nH:13][c:12]1[CH3:11])[NH:8][C:9]#[N:10]|EP1334974A1_0021
7.3.4|[c:4]/[N&H0&+0&D2:3]=[C&H1&+0&D2:2]/[c:1]>>[c:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([cH:7][c:8]1[O:9][CH3:10])[CH2:11][CH2:12][CH2:13][n:14]1[c:15]-2[c:16]([n:17][c:18]1/[N:19]=[CH:20]/[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[F:27])-[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>>[CH3:10][O:9][c:8]1[cH:7][c:6]2[CH2:11][CH2:12][CH2:13][n:14]3[c:15]([c:16]([n:17][c:18]3[NH:19][CH2:20][c:21]3[cH:22][cH:23][c:24]([cH:25][cH:26]3)[F:27])-[c:28]3[cH:29][cH:30][cH:31][cH:32][cH:33]3)-[c:5]2[cH:4][c:3]1[O:2][CH3:1]|EP3495367A1_0446
7.7.1|[C:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[C:1]>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][C:2](=[O:3])[O:4][CH:5]([C:6]#[C:7][CH2:8][O:9][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][O:15]1)[CH2:16][O:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[F:24]>CCOC(C)=O.[H][H].[Pd]>[CH3:1][C:2](=[O:3])[O:4][CH:5]([CH2:16][O:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[F:24])[CH2:6][CH2:7][CH2:8][O:9][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][O:15]1|US04525298A
7.3.4|[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[N:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[N:1]|[CH3:1][CH2:2][CH2:3][CH:4]([CH:5]=[N:6][NH:7][C:8](=[O:9])[O:10][CH3:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[Cl:18])[Cl:19]>CC(=O)O.[Pt]>[CH3:1][CH2:2][CH2:3][CH:4]([CH2:5][NH:6][NH:7][C:8](=[O:9])[O:10][CH3:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[Cl:18])[Cl:19]|US09303007B2_1062
7.3.4|[C:4]/[N&H0&+0&D2:3]=[C&H1&+0&D2:2]/[c:1]>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[OH:1][CH2:2][CH2:3][CH2:4]/[N:5]=[CH:6]/[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1>[Na+].[BH4-]>[OH:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1|US20130131018A1_1515
7.3.4|[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[O:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[O:1]|[CH3:1][O:2][N:3]=[CH:4][CH2:5][CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[F:13]>[Na+].N#C[BH3-]>[CH3:1][O:2][NH:3][CH2:4][CH2:5][CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[F:13]|US10611781B2_0474
7.3.4|[C:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:2]-[N:1]>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[N:1]|[O:1]=[C:2]1[N:3]=[CH:4][N:5]([C:6]11[CH2:7][CH2:8][N:9]([CH2:10][CH2:11]1)[C@H:12]1[CH2:13][CH2:14][CH2:15][CH2:16][C@H:17]1[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH2:24][CH2:25][C:26]([F:27])([F:28])[F:29]>>[O:1]=[C:2]1[NH:3][CH2:4][N:5]([C:6]11[CH2:7][CH2:8][N:9]([CH2:10][CH2:11]1)[C@H:12]1[CH2:13][CH2:14][CH2:15][CH2:16][C@H:17]1[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH2:24][CH2:25][C:26]([F:27])([F:28])[F:29]|US07189850B2_0232
8.8.18|[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[C:1]>>[C:4]/[C&H1&+0&D2:3]=[C&H1&+0&D2:2]/[C:1]|[CH3:1][CH2:2][CH:3]([CH3:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:20])[OH:21]>>[CH3:1][CH2:2][CH:3]([CH3:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]/[CH:10]=[CH:11]/[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:20])[OH:21]|EP2772527A1_0042
7.7.1|[c:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[c:1]>>[c:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[ClH:1].[CH3:2][C:3]([CH3:4])([NH2:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[C:12]#[C:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>CO.[O-2].[O-2].[Pt+4]>[ClH:1].[CH3:2][C:3]([CH3:4])([NH2:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH2:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US07375113B2_0396
7.3.4|[O:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[O:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH:1](=[N:2][O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>[Na+].Cl.CO.CN(C)c1ccc(cc1)N=Nc1ccc(cc1)S(=O)(=O)O.N#C[BH3-].O[Na]>[cH:8]1[cH:7][cH:6][c:5]([cH:10][cH:9]1)[CH2:4][O:3][NH:2][CH2:1][c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US07745663B2_1137
7.6.1|[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][NH:2][C:3](=[O:4])[O:5][CH:6]1[O:7][C:8]([CH:9]2[CH:10]3[CH:11]=[CH:12][CH:13]([CH2:14]3)[CH:15]12)=[O:16]>O=[Si]=O.C1CCOC1.[H][H].[Ni]>[CH3:1][NH:2][C:3](=[O:4])[O:5][CH:6]1[O:7][C:8]([CH:9]2[CH:10]3[CH2:11][CH2:12][CH:13]([CH2:14]3)[CH:15]12)=[O:16]|EP0356154B1_0072
7.3.4|[C:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH2:6][O:7][c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[CH:14]=[N:15][CH2:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>[Na+].CO.[BH4-]>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH2:6][O:7][c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[CH2:14][NH:15][CH2:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20120264910A1_0053
7.7.1|[C:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][c:11]([cH:12][cH:13][c:14]1[C:15]#[C:16][CH2:17][N:18]1[C:19]([c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[C:26]1=[O:27])=[O:28])[Cl:29]>C1CCOC1.[Ni]>[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][c:11]([cH:12][cH:13][c:14]1[CH2:15][CH2:16][CH2:17][N:18]1[C:19]([c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[C:26]1=[O:27])=[O:28])[Cl:29]|US20110060146A1_0455
7.6.1|[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[N:1]>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[N:1]|[CH3:1][CH:2]([CH:3]=[CH:4][N:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1)[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>CCO.[Ni]>[CH3:1][CH:2]([CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1)[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|EP3480198A1_0273
7.9.8|[C:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[C:1]>>[C:4]/[C&H1&+0&D2:3]=[C&H1&+0&D2:2]\[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[CH2:9][CH2:10][C:11]#[C:12][CH:13]([OH:14])[CH:15]([Cl:16])[CH2:17][CH3:18]>CCOC(C)=O.c1ccnc2ccccc12.[Pd]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[CH2:9][CH2:10]/[CH:11]=[CH:12]\[CH:13]([OH:14])[CH:15]([Cl:16])[CH2:17][CH3:18]|US03953499A
8.8.18|[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[C:1]>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[CH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1>CCOC(=O)C1CCCCCCCCCCC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[CH:7][CH:8]=[CH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1|US20090054376A1_0298
7.6.1|[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[S:1]>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[S:1]|[O:1]=[c:2]1[nH:3][c:4]2[cH:5][c:6]([c:7]([cH:8][c:9]2[o:10]1)[NH:11][CH2:12][CH:13]1[CH2:14][S:15][CH:16]=[CH:17][CH2:18]1)[F:19]>>[O:1]=[c:2]1[nH:3][c:4]2[cH:5][c:6]([c:7]([cH:8][c:9]2[o:10]1)[NH:11][CH2:12][CH:13]1[CH2:14][S:15][CH2:16][CH2:17][CH2:18]1)[F:19]|US20130150376A1_0281
7.6.1|[O:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[O:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][O:2][CH:3]=[CH:4][c:5]1[cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[cH:13][n:14]1>CO.[Pd]>[CH3:1][O:2][CH2:3][CH2:4][c:5]1[cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[cH:13][n:14]1|US20200253974A1_0396
7.6.1|[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[P:1]>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[P:1]|[CH3:1][CH2:2][O:3][P:4](=[O:5])([CH:6]=[CH:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)-[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[O:21][C@H:22]1[O:23][C@@H:24]([C@H:25]([C@@H:26]([C@@H:27]1[OH:28])[OH:29])[OH:30])[CH2:31][OH:32])[O:33][CH2:34][CH3:35]>CCO.[Pd]>[CH3:1][CH2:2][O:3][P:4](=[O:5])([CH2:6][CH2:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)-[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[O:21][C@H:22]1[O:23][C@@H:24]([C@H:25]([C@@H:26]([C@@H:27]1[OH:28])[OH:29])[OH:30])[CH2:31][OH:32])[O:33][CH2:34][CH3:35]|US20100331397A1_0267
7.6.1|[S:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[S:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])[CH:7]=[CH:8][c:9]1[cH:10][cH:11][c:12]2[nH:13][cH:14][cH:15][c:16]2[cH:17]1>CCO.[O-2].[Pd+2]>[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])[CH2:7][CH2:8][c:9]1[cH:10][cH:11][c:12]2[nH:13][cH:14][cH:15][c:16]2[cH:17]1|US05659040A
7.3.4|[C:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][CH:2]([CH3:3])[CH:4]=[N:5][CH2:6][CH2:7][CH:8]([CH3:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>CO.O=[Pt]=O>[CH3:9][CH:8]([CH2:7][CH2:6][NH:5][CH2:4][CH:2]([CH3:1])[CH3:3])[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|EP0001616A2_0046
7.3.4|[c:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[c:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][C:2](=[O:3])[NH:4][NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N:12]=[CH:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>CCO.[H][H].[O-2].[Pt+2]>[CH3:1][C:2](=[O:3])[NH:4][NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[NH:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US09566577B1_0055
7.9.8|[C:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[C:1]>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]|[CH3:1][C:2]([C:3]#[C:4][CH:5]([O:6][CH2:7][CH3:8])[O:9][CH2:10][CH3:11])=[CH:12][CH2:13][OH:14]>c1ccnc2ccccc12.[Pd]>[CH3:8][CH2:7][O:6][CH:5]([CH:4]=[CH:3][C:2]([CH3:1])=[CH:12][CH2:13][OH:14])[O:9][CH2:10][CH3:11]|US20140051577A1_0162
7.3.4|[N:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[S:1]>>[N:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[S:1]|[O:1]=[S:2]1([N:3]=[CH:4][NH:5][c:6]2[n:7][cH:8][cH:9][cH:10][c:11]21)=[O:12]>O.[Na+].Cl.[BH4-]>[O:1]=[S:2]1([NH:3][CH2:4][NH:5][c:6]2[n:7][cH:8][cH:9][cH:10][c:11]21)=[O:12]|EP2147915A1_0300
2.8.5|[C:4]-[S&H0&-&D1:3].[C:2]-[C&H2&+0&D2:1]-O>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12]1)[CH2:13][N:14]([c:15]1[cH:16][cH:17][c:18]([cH:19][c:20]12)[CH2:21][CH2:22][CH2:23][CH2:24]O)[C:25](=[O:26])[O:27][CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33].[CH3:34][C:35](=[O:36])[S-:37].[K+]>CCN(CC)CC.CS(=O)(=O)Cl.C1CCOC1.O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:13][N:14]([c:15]3[cH:16][cH:17][c:18]([cH:19][c:20]32)[CH2:21][CH2:22][CH2:23][CH2:24][S:37][C:35]([CH3:34])=[O:36])[C:25](=[O:26])[O:27][CH2:28][CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33])[CH2:12]1|US20200368173A1_1575
2.6.2|[C:4]-[O&H0&-&D1:3].[O:2]-[C&H2&+0&D2:1]-I>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[O:2]|[Na+].[CH3:1][O:2][N:3]=[C:4]([C:5](=[O:6])[NH:7][CH:8]1[C:9]([N:10]2[C:11](=[C:12]([CH2:13][S:14][C@H:15]12)[CH2:16][S:17][c:18]1[n:19][n:20][cH:21][s:22]1)[C:23]([O-:24])=[O:25])=[O:26])[c:27]1[cH:28][s:29][c:30]([n:31]1)[NH2:32].[CH3:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38](=[O:39])[O:40][CH2:41]I>O.CCOC(C)=O.CN(C)C=O>[CH3:1][O:2][N:3]=[C:4]([C:5](=[O:6])[NH:7][CH:8]1[C:9]([N:10]2[C:11](=[C:12]([CH2:13][S:14][C@H:15]12)[CH2:16][S:17][c:18]1[n:19][n:20][cH:21][s:22]1)[C:23](=[O:25])[O:24][CH2:41][O:40][C:38](=[O:39])[CH2:37][CH2:36][CH2:35][CH2:34][CH3:33])=[O:26])[c:27]1[cH:28][s:29][c:30]([n:31]1)[NH2:32]|US20200017495A1_0377
10.4.5|[N&H4&+&D0:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[N&H2&+0&D1:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][c:7]2[c:8]([cH:9][c:10]([c:11]([c:12]2[o:13]1)-[n:14]1[c:15]([cH:16][c:17]([nH:18][c:19]1=[O:20])[C:21]([F:22])([F:23])[F:24])=[O:25])[F:26])[Cl:27].[NH4+:28].[Cl-]>Cc1cc(c(c(c1)C)S(=O)(=O)ON)C.O=C(O[K])O[K].C1CCOC1.O>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][c:7]2[c:8]([cH:9][c:10]([c:11]([c:12]2[o:13]1)-[n:14]1[c:15]([cH:16][c:17]([n:18]([c:19]1=[O:20])[NH2:28])[C:21]([F:22])([F:23])[F:24])=[O:25])[F:26])[Cl:27]|US20200239478A1_0217
10.4.5|[N&H4&+&D0:4].[c:3]:[c&H1&+0&D2:2]:[n:1]>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[cH:1]1[n:2][cH:3][c:4]2[nH:5][cH:6][n:7][c:8]2[n:9]1.[NH4+:10].[OH-]>C[C@H](NC(=O)Cc1cc(cc(c1)F)F)C(=O)N[C@H](C(=O)OC(C)(C)C)c1ccccc1.[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O.CP([O-])([O-])=O.Cl>[NH2:10][c:3]1[n:2][cH:1][n:9][c:8]2[n:7][cH:6][nH:5][c:4]21|US20200385379A1_0226
6.1.5|[C&H3&D1:3]-[N&H0&+0&D3:2](-[S:1])-C-c1:c:c:c:c:c:1>>[C&H3&D1:3]-[N&H1&+0&D2:2]-[S:1]|[CH3:1][N:2](Cc1ccccc1)[S:3](=[O:4])(=[O:5])[CH2:6][C:7]([NH2:8])=[O:9]>CO.[OH-].[OH-].[Pd+2]>[CH3:1][NH:2][S:3](=[O:4])(=[O:5])[CH2:6][C:7]([NH2:8])=[O:9]|US20200407327A1_0920
10.4.5|[N&H4&+&D0:4].[c:3]:[c&H1&+0&D2:2]:[c:1]>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH4+:1].[Cl-].[CH3:2][S:3][CH2:4][CH2:5][NH:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1>[Zn]>[CH3:2][S:3][CH2:4][CH2:5][NH:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[NH2:1]|EP0735025A1_0035
2.6.2|[C:4]-[C&H2&+0&D2:3]-I.[C:2]-[O&H0&-&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[Na+].[Na+:1].[O-:2][N+:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22](=[O:23])[NH:24][c:25]1[n:26][c:27]([n:28]([cH:29][c:30]1[Br:31])[C@@H:32]1[O:33][C@@H:34]([C@H:35]([C@H:36]1[OH:37])[OH:38])[CH2:39]I)=[O:40].[O-:41][C:42](=[O:43])[C:44]1([CH2:45][CH2:46][CH2:47]1)[C:48]([O-:49])=[O:50]>CC#N>[Na+:1].[O-:2][N+:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22](=[O:23])[NH:24][c:25]1[n:26][c:27]([n:28]([cH:29][c:30]1[Br:31])[C@@H:32]1[O:33][C@@H:34]([C@H:35]([C@H:36]1[OH:37])[OH:38])[CH2:39][O:41][C:42](=[O:43])[C:44]1([CH2:45][CH2:46][CH2:47]1)[C:48]([O-:49])=[O:50])=[O:40]|US20190153017A1_0510
1.2.1|[C:4]-[N&H3&+&D1:3].[C:2]-[C&H1&+0&D2:1]=O>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][n:8]1)[C@@H:9]([NH3+:10])[CH2:11][C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18].[CH3:19][O:20][CH:21]([CH:22]=O)[O:23][CH3:24]>CC(=O)O[BH-](OC(C)=O)OC(C)=O.N#C[BH3-].[Na+].[Na+]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][n:8]1)[C@H:9]([CH2:11][C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[NH:10][CH2:22][CH:21]([O:23][CH3:24])[O:20][CH3:19]|US10487093B2_0816
1.2.1|[C:4]-[N&H3&+&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[NH2:1][C:2](=[O:3])[c:4]1[n:5][cH:6][c:7]2[cH:8][c:9]([c:10]([n:11][c:12]2[n:13]1)-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH:20]=O)-[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1.[NH3+:27][CH2:28][CH2:29][C:30](=[O:31])[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.[Cl-]>CC(=O)O[BH-](OC(C)=O)OC(C)=O.CN(C)C=O.CC(=O)O.O.[Na+]>[NH2:1][C:2](=[O:3])[c:4]1[n:5][cH:6][c:7]2[cH:8][c:9]([c:10]([n:11][c:12]2[n:13]1)-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20][NH:27][CH2:28][CH2:29][C:30](=[O:31])[c:32]1[cH:37][cH:36][cH:35][cH:34][cH:33]1)-[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1|US20180263996A1_0552
1.8.15|[C:4]-[S&H1&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-I>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[O:1]=[C:2]([OH:3])[CH2:4]I.[F:5][C:6]([F:7])([F:8])[SH:9].[Ag]>CC(C)=O>[O:1]=[C:2]([OH:3])[CH2:4][S:9][C:6]([F:5])([F:7])[F:8]|US20200030716A1_0240
2.6.2|[C:4]-[O&H1&+0&D1:3].[O:2]-[C&H2&+0&D2:1]-I>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[O:2]|[CH3:1][c:2]1[n:3][n:4][c:5]([s:6]1)[S:7][CH2:8][C:9]1[CH2:10][S:11][CH:12]2[CH:13]([C:14]([N:15]2[C:16]=1[C:17](=[O:18])[OH:19])=[O:20])[NH:21][C:22](=[O:23])[CH2:24][c:25]1[cH:26][s:27][c:28]([s:29]1)=[O:30].[CH3:31][C:32]([CH3:33])([CH3:34])[C:35](=[O:36])[O:37][CH2:38]I>CCOC(C)=O.CN(C)C=O.O.[K]>[CH3:1][c:2]1[n:3][n:4][c:5]([s:6]1)[S:7][CH2:8][C:9]1[CH2:10][S:11][CH:12]2[CH:13]([C:14]([N:15]2[C:16]=1[C:17](=[O:18])[O:19][CH2:38][O:37][C:35](=[O:36])[C:32]([CH3:31])([CH3:33])[CH3:34])=[O:20])[NH:21][C:22](=[O:23])[CH2:24][c:25]1[cH:26][s:27][c:28]([s:29]1)=[O:30]|US20190300526A1_0293
9.7.60|[C:4]-[C&H0&+0&D4:3](-[C:2])(-[O&H1&D1:1])-O>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[O&H1&D1:1]|[CH2:1]=[C:2]([CH3:3])[C:4](=[O:5])[O:6][CH2:7][C:8]([CH3:9])([OH:10])[C:11]([F:12])([F:13])[C:14]([OH:15])(O)[C:16]([F:17])([F:18])[F:19]>ClCCl.Cl>[CH2:1]=[C:2]([CH3:3])[C:4](=[O:5])[O:6][CH2:7][C:8]([CH3:9])([OH:10])[C:11]([F:13])([F:12])[CH:14]([OH:15])[C:16]([F:17])([F:18])[F:19]|US20020082426A1_0141
1.2.1|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([CH3:8])[NH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[NH2:16].[CH3:17][CH:18]([CH3:19])[O:20][CH2:21][CH2:22][CH:23]=O>CO.[H][H].[S-2].[Pt+2]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([CH3:8])[NH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[NH:16][CH2:23][CH2:22][CH2:21][O:20][CH:18]([CH3:17])[CH3:19]|US08084448B2_1595
1.8.15|[C:4]-[C&H2&+0&D2:3]-I.[S&H1&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4]I.[NH2:5][S:6](=[O:7])(=[O:8])[c:9]1[cH:10][c:11]([cH:12][c:13]([c:14]1[Cl:15])[SH:16])[C:17](=[O:18])[OH:19]>O[Na]>[CH3:1][CH2:2][CH2:3][CH2:4][S:16][c:13]1[cH:12][c:11]([cH:10][c:9]([c:14]1[Cl:15])[S:6]([NH2:5])(=[O:7])=[O:8])[C:17](=[O:18])[OH:19]|EP1899294B1_0116
1.6.8|[C:4]-[C&H2&+0&D2:3]-I.[N&H2&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[CH2:1]=[C:2]([CH3:3])[CH2:4]I.[CH3:5][C:6](=[O:7])[NH:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[S:15][c:16]1[c:17]([cH:18][c:19]([cH:20][c:21]1[S:22]([NH2:23])(=[O:24])=[O:25])[C:26](=[O:27])[OH:28])[NH2:29]>O.CCO.O[Li]>[CH2:1]=[C:2]([CH3:3])[CH2:4][NH:29][c:17]1[cH:18][c:19]([cH:20][c:21]([c:16]1[S:15][c:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[NH:8][C:6]([CH3:5])=[O:7])[S:22]([NH2:23])(=[O:24])=[O:25])[C:26](=[O:27])[OH:28]|US20180072997A1_0413
1.2.2|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[O:1]>>[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[O:1]|Cl.[CH3:1][O:2][NH2:3].O=[CH:4][C:5]1[CH2:6][S:7][C@@H:8]2[C@@H:9]([C:10]([N:11]2[C:12]=1[C:13](=[O:14])[OH:15])=[O:16])[NH:17][C:18](=[O:19])[CH2:20][c:21]1[cH:22][cH:23][cH:24][s:25]1>O.C1CCOC1>[CH3:1][O:2][N:3]=[CH:4][C:5]1[CH2:6][S:7][C@@H:8]2[C@@H:9]([C:10]([N:11]2[C:12]=1[C:13](=[O:14])[OH:15])=[O:16])[NH:17][C:18](=[O:19])[CH2:20][c:21]1[cH:22][cH:23][cH:24][s:25]1|US20190161460A1_0341
2.6.2|[C:4]-[O&H0&-&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[Na+].[CH3:1][C:2]([O-:3])=[O:4].Cl[CH2:5][c:6]1[cH:7][cH:8][c:9]([n:10][c:11]1[Cl:12])[Cl:13]>CC(=O)O>[CH3:1][C:2](=[O:4])[O:3][CH2:5][c:6]1[cH:7][cH:8][c:9]([n:10][c:11]1[Cl:12])[Cl:13]|US20170371242A1_0149
1.7.9|[C:4]-[O&H1&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-I>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][OH:3].[O-:4][N+:5](=[O:6])[c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[CH2:13]I)[N:14]1[C:15]([c:16]2[cH:17][cH:18][c:19]([cH:20][c:21]2[C:22]1=[O:23])[Cl:24])=[O:25]>[O-]C([O-])=O.C1CCOC1.[Ag+].[Ag+]>[CH3:1][CH2:2][O:3][CH2:13][c:11]1[cH:12][c:7]([cH:8][cH:9][c:10]1[N:14]1[C:22]([c:21]2[cH:20][c:19]([cH:18][cH:17][c:16]2[C:15]1=[O:25])[Cl:24])=[O:23])[N+:5]([O-:4])=[O:6]|US07732471B2_0262
1.6.8|[C:4]-[N&H2&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-I>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16]I.[NH2:17][CH2:18][CH2:19][CH2:20][P:21](=[O:22])([OH:23])[OH:24]>CCCC[N+](CCCC)(CCCC)CCCC.CC(C)N(CC)C(C)C.CO.Cl.[OH-]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][NH:17][CH2:18][CH2:19][CH2:20][P:21](=[O:22])([OH:23])[OH:24]|EP1581495B1_0056
1.2.9|[C:4]-[N&H2&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-O>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[NH2:1][CH2:2][CH2:3][NH2:4].O[CH2:5][c:6]1[cH:7][cH:8][nH:9][n:10]1>O=S(Br)Br.BrCc1cc[nH]n1>[NH2:4][CH2:3][CH2:2][NH:1][CH2:5][c:6]1[cH:7][cH:8][nH:9][n:10]1|US08158628B2_0695
1.8.12|[C:4]-[C&H2&+0&D2:3]-Br.[S&H0&-&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[Na+].[O:1]=[C:2]1[CH2:3][CH:4]2[O:5][CH:6]([CH2:7][N:8]12)[CH2:9]Br.[S-:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>CCOC(C)=O.CN(C)C=O>[O:1]=[C:2]1[CH2:3][CH:4]2[O:5][CH:6]([CH2:7][N:8]12)[CH2:9][S:10][c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US20090156612A1_1521
1.2.2|[C:4]-[N&H2&+0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:4]/[N&H0&+0&D2:3]=[C&H1&+0&D2:1]\[c:2]|[NH2:1][CH2:2][CH:3]1[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1.O=[CH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>Cc1ccccc1>[CH:9](=[N:1]/[CH2:2][CH:3]1[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1)/[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US20180141902A1_0129
9.7.140|[C:4]-[C&H0&+0&D4:3](-[C:2])(-[F&H0&D1:1])-F>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[F&H0&D1:1]|[F:1][C:2]([F:3])([F:4])[C:5]([F:6])(F)[C:7]([F:8])([F:9])[F:10]>>[F:8][C:7]([F:9])([F:10])[CH:5]([F:6])[C:2]([F:1])([F:3])[F:4]|US09402833B2_0662
1.7.7|[C:4]-[C&H2&+0&D2:3]-O.[O&H1&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])[O:4][CH2:5][CH2:6][CH:7]=[CH:8][CH2:9]O.[OH:10][c:11]1[cH:12][cH:13][c:14]2[O:15][CH2:16][O:17][c:18]2[cH:19]1>CCOCC.C(=NC1CCCCC1)=NC1CCCCC1>[CH3:1][CH:2]([CH3:3])[O:4][CH2:5][CH2:6][CH:7]=[CH:8][CH2:9][O:10][c:11]1[cH:12][cH:13][c:14]2[O:15][CH2:16][O:17][c:18]2[cH:19]1|US08293897B2_0486
1.7.9|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[O&H0&-&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH:2]([CH3:3])[CH2:4][O-:5].[CH3:6][C:7](=[CH:8][CH2:9][O:10][c:11]1[cH:12][cH:13][c:14]2[O:15][CH2:16][O:17][c:18]2[cH:19]1)[CH2:20]Br.[Na]>CC(C)CO>[CH3:6][C:7](=[CH:8][CH2:9][O:10][c:11]1[cH:12][cH:13][c:14]2[O:15][CH2:16][O:17][c:18]2[cH:19]1)[CH2:20][O:5][CH2:4][CH:2]([CH3:1])[CH3:3]|EP3333149B1_0130
1.8.13|[C:4]-[S&H0&-&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[N:1]#[C:2][N:3]=[C:4]([S-:5])[S-:6].Cl[CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14].[K+].[K+:15]>O.CO>[N:1]#[C:2][N:3]=[C:4]([S-:5])[S:6][CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14].[K+:15]|US08461134B2_0601
2.6.2|[C:4]-[O&H0&-&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[Na+].[CH3:1][C:2]1([S:3][C@@H:4]2[C@@H:5]([C:6]([N:7]2[C@H:8]1[C:9]([O-:10])=[O:11])=[O:12])[NH:13][CH:14]=[O:15])[CH3:16].[O-:17][N+:18](=[O:19])[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[CH2:26]Br>CN(C)C=O>[CH3:1][C:2]1([S:3][C@@H:4]2[C@@H:5]([C:6]([N:7]2[C@H:8]1[C:9](=[O:11])[O:10][CH2:26][c:23]1[cH:24][cH:25][c:20]([cH:21][cH:22]1)[N+:18]([O-:17])=[O:19])=[O:12])[NH:13][CH:14]=[O:15])[CH3:16]|US08450522B2_0887
2.6.9|[C:4]-[O&H1&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-O>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[c:8]1[cH:9][cH:10][cH:11][cH:12]2)[CH2:13][C:14]1=[CH:15][S:16][C@@H:17]2[C@@H:18]([C:19]([N:20]2[CH:21]1[C:22](=[O:23])[OH:24])=[O:25])[NH:26][C:27](=[O:28])[CH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1.O[CH2:36][C:37]([Cl:38])([Cl:39])[Cl:40]>C(=NC1CCCCC1)=NC1CCCCC1.c1ccncc1.ClCCl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[c:8]1[cH:9][cH:10][cH:11][cH:12]2)[CH2:13][C:14]1=[CH:15][S:16][C@@H:17]2[C@@H:18]([C:19]([N:20]2[CH:21]1[C:22](=[O:23])[O:24][CH2:36][C:37]([Cl:38])([Cl:39])[Cl:40])=[O:25])[NH:26][C:27](=[O:28])[CH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1|US06355646B1
8.4.2|[O&H1&+0&D1:4]-O.[c:3]:[n&H0&+0&D2:2]:[c:1]>>[O&H0&-&D1:4]-[n&H0&+&D3:2](:[c:3]):[c:1]|[CH3:1][n:2]1[n:3][c:4]([c:5]2[c:6]([n:7][cH:8][n:9][c:10]21)[NH2:11])-[c:12]1[cH:13][cH:14][c:15]([o:16]1)[N+:17]([O-:18])=[O:19].[OH:20]O>CC(=O)O>[CH3:1][n:2]1[n:3][c:4]([c:5]2[c:10]1[n:9][cH:8][n+:7]([c:6]2[NH2:11])[O-:20])-[c:12]1[cH:13][cH:14][c:15]([o:16]1)[N+:17]([O-:18])=[O:19]|US07989451B2_0488
2.8.5|[C:4]-[S&H0&-&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[NH:11][C:12](=[O:13])[CH2:14]Cl.[CH3:15][C:16](=[O:17])[S-:18].[K+]>CCCCCC.CC(C)=O>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[NH:11][C:12](=[O:13])[CH2:14][S:18][C:16]([CH3:15])=[O:17]|US20180282323A1_0610
2.8.5|[C:4]-[S&H1&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-O>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH2:1]=[CH:2][O:3][C:4](=[O:5])[N:6]=[c:7]1[s:8][c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[n:15]1[CH2:16][CH2:17]O)[O:18][C:19]([F:20])([F:21])[F:22].[CH3:23][C:24](=[O:25])[SH:26]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)N=NC([O-])=O.C1CCOC1.CO>[CH2:1]=[CH:2][O:3][C:4](=[O:5])[N:6]=[c:7]1[s:8][c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[n:15]1[CH2:16][CH2:17][S:26][C:24]([CH3:23])=[O:25])[O:18][C:19]([F:20])([F:21])[F:22]|US08808703B2_0696
1.7.9|[C:4]-[C&H2&+0&D2:3]-Cl.[O&H0&-&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[Na+].[CH3:1][C:2]1([O:3][CH2:4][C:5]([O:6]1)([CH3:7])[CH2:8]Cl)[CH3:9].[O-:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O.CS(C)=O>[CH3:9][C:2]1([O:3][CH2:4][C:5]([O:6]1)([CH3:7])[CH2:8][O:10][c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1)[CH3:1]|EP1123913A2_0028
9.7.60|[C&H3&D1:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-O>>[C&H3&D1:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|Cl.[CH3:1][C:2]1([O:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][c:9]([c:10]2[O:11]1)[C:12]([CH3:13])(O)[c:14]1[cH:15][nH:16][cH:17][n:18]1)[CH3:19]>>[CH3:1][C:2]1([O:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][c:9]([c:10]2[O:11]1)[CH:12]([CH3:13])[c:14]1[cH:15][nH:16][cH:17][n:18]1)[CH3:19]|US10131670B2_0273
2.6.9|[C:4]=[N&H0&+0&D2:3]-O.[C:2]-[O&H1&+0&D1:1]>>[C:4]=[N&H0&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH:2]([O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[C:17]([F:18])([F:19])[F:20])[C:21](=[O:22])[OH:23].[CH3:24][C:25]([CH3:26])=[N:27]O>C(=NC1CCCCC1)=NC1CCCCC1.ClCCl>[CH3:24][C:25]([CH3:26])=[N:27][O:23][C:21](=[O:22])[CH:2]([CH3:1])[O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[C:17]([F:18])([F:19])[F:20]|EP0386940A1_0119
1.2.2|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[N:1]>>[C:4]/[C&H1&+0&D2:3]=[N&H0&+0&D2:2]\[N:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][NH2:9].O=[CH:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1>CO>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8]/[N:9]=[CH:10]\[CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1|US07511050B2_0881
1.2.2|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[N:1]>>[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[N:1]|[NH2:1][NH:2][C:3]([NH2:4])=[S:5].[O-:6][N+:7](=[O:8])[c:9]1[cH:10][cH:11][c:12]([o:13]1)[CH:14]=[C:15]([CH:16]=O)[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Br:23]>[Na+].CO.CC([O-])=O.CC(=O)O>[NH2:4][C:3](=[S:5])[NH:2][N:1]=[CH:16][C:15](=[CH:14][c:12]1[cH:11][cH:10][c:9]([o:13]1)[N+:7]([O-:6])=[O:8])[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Br:23]|US20200165256A1_0454
1.2.1|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[O:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[O:1]|Cl.[N:1]#[C:2][CH2:3][CH2:4][CH2:5][CH:6]=O.[NH2:7][O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>O.[Na+].Cl.CO.CCOCC.N#C[BH3-].NO.O[K]>[N:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][NH:7][O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US07713994B2_3880
3.9.19|[C&H1&+0&D1:4]#[C:3].[C&H1&+0&D1:2]#[C:1]>>[C&H0&+0&D2:4](-[C&H0&+0&D2:2]#[C:1])#[C:3]|[CH:1]#[C:2][C:3]1([CH2:4][CH2:5][CH:6]([CH2:7][CH2:8]1)[CH:9]1[CH2:10][CH2:11][CH:12]([CH2:13][CH2:14]1)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24].[CH:25]#[C:26][C:27]1([CH2:28][CH2:29][CH:30]([CH2:31][CH2:32]1)[CH:33]1[CH2:34][CH2:35][CH:36]([CH2:37][CH2:38]1)[CH2:39][CH2:40][CH3:41])[O:42][CH3:43]>O.CC([O-])=O.CC([O-])=O.CO.I[Cu].c1ccncc1.[Cu+2]>[CH3:41][CH2:40][CH2:39][CH:36]1[CH2:35][CH2:34][CH:33]([CH2:38][CH2:37]1)[CH:30]1[CH2:29][CH2:28][C:27]([CH2:32][CH2:31]1)([C:26]#[C:25][C:1]#[C:2][C:3]1([CH2:4][CH2:5][CH:6]([CH2:7][CH2:8]1)[CH:9]1[CH2:10][CH2:11][CH:12]([CH2:13][CH2:14]1)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[O:42][CH3:43]|US10611747B2_0354
8.4.2|[C:4]-[N&H1&+0&D2:3]-[c:2].[O&H1&+0&D1:1]-O>>[C:4]-[N&H1&+&D3:3](-[O&H0&-&D1:1])-[c:2]|[CH3:1][c:2]1[cH:3][c:4]([n:5][c:6]([cH:7]1)[NH:8][C:9](=[O:10])[c:11]1[cH:12][n:13][cH:14][cH:15][n:16]1)[CH3:17].[OH:18]O>CC(=O)O>[CH3:1][c:2]1[cH:3][c:4]([n:5][c:6]([cH:7]1)[NH+:8]([O-:18])[C:9](=[O:10])[c:11]1[cH:12][n:13][cH:14][cH:15][n:16]1)[CH3:17]|US20200223822A1_0422
2.6.2|[C:4]-[O&H0&-&D1:3].[O:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[O:2]|[CH3:1][C:2]([O-:3])=[O:4].[O:5]=[C:6]([O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14]Cl)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[Ag+]>CC#N>[CH3:1][C:2](=[O:4])[O:3][CH2:14][O:13][CH2:12][CH2:11][O:10][CH2:9][CH2:8][O:7][C:6](=[O:5])[c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|US20170342064A1_0239
1.2.2|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[S:1]>>[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[S:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8]([CH3:9])([NH2:10])[OH:11].[CH3:12][C@H:13]([O:14][CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][O:20]1)[C@H:21]([CH3:22])[CH:23]=O>>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8]([CH3:9])([OH:11])[N:10]=[CH:23][C@@H:21]([CH3:22])[C@H:13]([CH3:12])[O:14][CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][O:20]1|US08163956B2_0220
1.2.1|[C:4]-[N&H2&+0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[NH2:1][CH2:2][CH:3]([OH:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[Cl:11])[Cl:12].[CH3:13][O:14][c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[CH:21]=O.[ClH:22]>c1ccccc1.O>[CH3:13][O:14][c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[CH2:21][NH:1][CH2:2][CH:3]([OH:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[Cl:11])[Cl:12].[ClH:22]|EP1724258A1_0848
1.2.9|[C:4]=[C&H1&+0&D2:3]-O.[C:2]-[N&H2&+0&D1:1]>>[C:4]=[C&H1&+0&D2:3]-[N&H1&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[c:7]2[cH:8][c:9]([c:10]([cH:11][c:12]2[C:13]([C:14]([CH:15]1[CH3:16])=[CH:17]O)=[O:18])[O:19][CH3:20])[O:21][CH3:22].[CH3:23][CH:24]([CH3:25])[NH2:26]>c1ccccc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[c:7]2[cH:8][c:9]([c:10]([cH:11][c:12]2[C:13]([C:14]([CH:15]1[CH3:16])=[CH:17][NH:26][CH:24]([CH3:23])[CH3:25])=[O:18])[O:19][CH3:20])[O:21][CH3:22]|US20200123111A1_0083
9.7.60|[C&H3&D1:4]-[C&H0&+0&D4:3](-[C:2])(-[c:1])-O>>[C&H3&D1:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[C:9]([CH3:10])(O)[CH:11]([CH3:12])[CH2:13][CH2:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21])[O:22][CH3:23]>[NH4+].[Cl-].CCOCC.CC(=O)O.COc1cc(cc(c1)C(=O)C(C)CCc1ccc(cc1)F)OC.C[Mg]Br.O=S(=O)(O)O.[Pd]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[CH:9]([CH3:10])[CH:11]([CH3:12])[CH2:13][CH2:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21])[O:22][CH3:23]|EP0009386B1_0232
1.2.9|[C:4]=[C&H1&+0&D2:3]-O.[N&H2&+0&D1:2]-[c:1]>>[C:4]=[C&H1&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[c:7]2[cH:8][c:9]([c:10]([cH:11][c:12]2[C:13]([C:14]([CH:15]1[CH3:16])=[CH:17]O)=[O:18])[O:19][CH3:20])[O:21][CH3:22].[NH2:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>c1ccccc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[c:7]2[cH:8][c:9]([c:10]([cH:11][c:12]2[C:13]([C:14]([CH:15]1[CH3:16])=[CH:17][NH:23][c:24]1[cH:29][cH:28][cH:27][cH:26][cH:25]1)=[O:18])[O:19][CH3:20])[O:21][CH3:22]|US07692005B2_0199
1.2.1|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[N:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[N:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7]/[CH:8]=[CH:9]\[CH2:10][C@H:11]1[CH2:12][O:13][C@H:14]([O:15][C@H:16]1[CH:17]=O)[CH3:18].[NH2:19][NH:20][C:21](=[O:22])[c:23]1[cH:24][cH:25][cH:26][s:27]1>[Na+].CCO.CC(=O)O.N#C[BH3-].O=C(O)O[Na]>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7]/[CH:8]=[CH:9]\[CH2:10][C@H:11]1[CH2:12][O:13][C@H:14]([O:15][C@H:16]1[CH2:17][NH:19][NH:20][C:21](=[O:22])[c:23]1[cH:24][cH:25][cH:26][s:27]1)[CH3:18]|US20200323869A1_0349
7.9.24|[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])=O>>[C:4]-[S&H0&+0&D3:3](=[O&H0&D1:2])-[c:1]|[O:1]=[C:2]([OH:3])[CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][CH2:12][CH2:13][S:14](=O)(=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22]>O=S(=O)(O)O.CC(C)=O.CC(C)=O.O=[Cr](=O)=O>[O:1]=[C:2]([OH:3])[CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][CH2:12][CH2:13][S:14](=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22]|US08513427B2_0107
1.2.2|[C:4]-[N&H2&+0&D1:3].[C:2]-[C&H1&+0&D2:1]=O>>[C:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:1]-[C:2]|Br.[NH2:1][CH:2]1[CH2:3][CH2:4][c:5]2[c:6]([c:7]([cH:8][cH:9][c:10]2[CH:11]1[OH:12])[OH:13])[OH:14].O=[CH:15][CH2:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>CCO>[OH:13][c:7]1[cH:8][cH:9][c:10]2[c:5]([CH2:4][CH2:3][CH:2]([CH:11]2[OH:12])[N:1]=[CH:15][CH2:16][CH2:17][c:18]2[cH:23][cH:22][cH:21][cH:20][cH:19]2)[c:6]1[OH:14]|US20200345732A1_0386
1.8.13|[C:4]-[C&H2&+0&D2:3]-Cl.[S&H0&-&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[Na+].[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[C:7]([NH:8][C:9](=[C:10]([CH:11]1[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[N+:18]([O-:19])=[O:20])[C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH2:26]Cl)[CH3:27].[S-:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1>CCO.CCO.COCCOC>[CH3:25][CH2:24][O:23][C:21](=[O:22])[C:10]1=[C:9]([NH:8][C:7](=[C:6]([CH:11]1[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[N+:18]([O-:19])=[O:20])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[CH3:27])[CH2:26][S:28][c:29]1[cH:34][cH:33][cH:32][cH:31][cH:30]1|EP3248969A1_0069
1.2.2|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[c:1]>>[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH2:8])[CH3:9].[CH3:10][O:11][CH2:12][CH:13]=O>c1ccccc1.CN(C)C.CO>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[N:8]=[CH:13][CH2:12][O:11][CH3:10])[CH3:9]|US09346852B2_0508
1.2.1|[C:4]-[N&H2&+0&D1:3].[C:2]-[C&H1&+0&D2:1]=O>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[NH2:5].O=[CH:6][C@H:7]([OH:8])[CH2:9][OH:10]>CCO.[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[NH:5][CH2:6][C@H:7]([OH:8])[CH2:9][OH:10]|US20200131167A1_0383
1.7.9|[C:4]-[C&H2&+0&D2:3]-Br.[O&H0&-&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[Na+].[CH2:1]=[CH:2][CH2:3][CH2:4]Br.[O-:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N+:12]([O-:13])=[O:14]>CN(C)C=O>[CH2:1]=[CH:2][CH2:3][CH2:4][O:5][c:6]1[cH:11][cH:10][c:9]([cH:8][cH:7]1)[N+:12]([O-:13])=[O:14]|US20110009454A1_1089
2.6.2|[C:4]-[C&H2&+0&D2:3]-Cl.[C:2]-[O&H0&-&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2]([O-:3])=[O:4].[CH3:5][CH:6]([CH3:7])[O:8][CH2:9][CH2:10][C:11]([CH3:12])=[CH:13][CH2:14]Cl.[K+]>CN(C)C=O>[CH3:1][C:2](=[O:4])[O:3][CH2:14][CH:13]=[C:11]([CH3:12])[CH2:10][CH2:9][O:8][CH:6]([CH3:5])[CH3:7]|EP2940024A1_0083
1.7.9|[C:4]-[C&H2&+0&D2:3]-I.[O&H1&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]I.[CH3:8][N:9]([CH3:10])[S:11](=[O:12])(=[O:13])[c:14]1[cH:15][cH:16][cH:17][c:18]2[NH:19][c:20]3[cH:21][c:22]([cH:23][cH:24][c:25]3[S:26][c:27]21)[OH:28]>CCC(C)=O.O[K]>[CH3:8][N:9]([CH3:10])[S:11](=[O:12])(=[O:13])[c:14]1[cH:15][cH:16][cH:17][c:18]2[NH:19][c:20]3[cH:21][c:22]([cH:23][cH:24][c:25]3[S:26][c:27]12)[O:28][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH3:1]|US20150023990A1_1074
1.2.9|[C:4]-[N&H2&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-O>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:38][CH2:39][CH2:40]O.[NH2:41][CH2:42][CH2:43][OH:44]>CS(=O)(=O)Cl.ClC(Cl)Cl>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:38][CH2:39][CH2:40][NH:41][CH2:42][CH2:43][OH:44]|US08076489B2_0105
1.2.2|[C:4]-[N&H2&+0&D1:3].[N:2]-[C&H1&+0&D2:1]=O>>[C:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:1]-[N:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[O:7][CH2:8][O:9][C:10](=[O:11])[C:12]1=[C:13]([CH2:14][S:15][C@@H:16]2[CH:17]([C:18]([N:19]12)=[O:20])[NH2:21])[CH3:22].[N-:23]=[N+:24]=[N:25][CH2:26][CH2:27][CH2:28][CH:29]1[CH2:30][CH2:31][N:32]([CH2:33][CH2:34]1)[CH:35]=O>CCN(CC)CC.C(C#[O+])#[O+].[Cl-].[Cl-]>[CH3:22][C:13]1[CH2:14][S:15][C@@H:16]2[CH:17]([C:18]([N:19]2[C:12]=1[C:10](=[O:11])[O:9][CH2:8][O:7][C:5](=[O:6])[C:2]([CH3:1])([CH3:3])[CH3:4])=[O:20])[N:21]=[CH:35][N:32]1[CH2:33][CH2:34][CH:29]([CH2:30][CH2:31]1)[CH2:28][CH2:27][CH2:26][N:25]=[N+:24]=[N-:23]|US20190151312A1_0524
2.6.2|[C:4]-[O&H0&-&D1:3].[O:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[O:2]|[CH3:1][n:2]1[n:3][n:4][n:5][c:6]1[S:7][CH2:8][C:9]1[CH2:10][S:11][C@@H:12]2[CH:13]([C:14]([N:15]2[C:16]=1[C:17]([O-:18])=[O:19])=[O:20])[NH:21][C:22](=[O:23])[CH2:24][S:25][C:26]([F:27])([F:28])[F:29].[CH3:30][C:31](=[O:32])[O:33][CH2:34]Br.[Na+]>CN(C)C=O.O>[CH3:30][C:31](=[O:32])[O:33][CH2:34][O:18][C:17](=[O:19])[C:16]1=[C:9]([CH2:10][S:11][C@@H:12]2[CH:13]([C:14]([N:15]12)=[O:20])[NH:21][C:22](=[O:23])[CH2:24][S:25][C:26]([F:27])([F:28])[F:29])[CH2:8][S:7][c:6]1[n:5][n:4][n:3][n:2]1[CH3:1]|US06001997A
8.4.2|[O&H1&+0&D1:4]-O.[c:3]:[n&H0&+0&D2:2]:[n:1]>>[O&H0&-&D1:4]-[n&H0&+&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH2:7][n:8]1[n:9][c:10]2[c:11]3[c:12]([S:13][c:14]4[cH:15][cH:16][cH:17][cH:18][c:19]4-2)[c:20]([cH:21][cH:22][c:23]31)[CH2:24][OH:25].O[OH:26]>CC(C)=O>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH2:7][n:8]1[c:23]2[cH:22][cH:21][c:20]([c:12]3[S:13][c:14]4[cH:15][cH:16][cH:17][cH:18][c:19]4-[c:10]([c:11]32)[n+:9]1[O-:26])[CH2:24][OH:25]|EP1532120B1_0183
1.2.9|[C:4]-[C&H2&+0&D2:3]-O.[N&H2&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4]O.[NH2:5][c:6]1[cH:7][c:8]([cH:9][c:10]([c:11]1[NH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[S:19]([NH2:20])(=[O:21])=[O:22])[C:23](=[O:24])[OH:25]>O.CCCCNc1cc(cc(c1Nc1ccccc1)S(N)(=O)=O)C(=O)OCCCC.O=S(=O)(O)O.O[Na]>[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][c:8]([cH:9][c:10]([c:11]1[NH:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)[S:19]([NH2:20])(=[O:21])=[O:22])[C:23](=[O:24])[OH:25]|US05618812A
2.6.2|[C:4]-[O&H1&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-I>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C@@:2]12[CH2:3][CH2:4][C@H:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@@:14]1([C@H:15]([CH2:16][CH2:17][C@@H:18]21)[C:19](=[O:20])[OH:21])[CH3:22])=[O:23])[OH:24].[CH3:25][CH2:26][CH2:27][CH2:28]I>CCN(CC)CC.CC(C)=O>[CH3:25][CH2:26][CH2:27][CH2:28][O:21][C:19](=[O:20])[C@H:15]1[CH2:16][CH2:17][C@H:18]2[C@@H:10]3[CH2:9][CH2:8][C@H:7]4[CH2:6][C@@H:5]([CH2:4][CH2:3][C@@:2]4([C@H:11]3[C:12]([CH2:13][C@@:14]21[CH3:22])=[O:23])[CH3:1])[OH:24]|US07223788B2_1095
2.6.9|[C:4]-[O&H1&+0&D1:3].[N:2]-[C&H2&+0&D2:1]-O>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[N:2]|[CH3:1][N:2]([CH3:3])[CH2:4][C:5](=[O:6])[OH:7].[O:8]=[C:9]1[NH:10][C:11]([C:12]([N:13]1[CH2:14]O)=[O:15])([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>C(=NC1CCCCC1)=NC1CCCCC1.c1ccncc1>[CH3:1][N:2]([CH3:3])[CH2:4][C:5](=[O:6])[O:7][CH2:14][N:13]1[C:9]([NH:10][C:11]([C:12]1=[O:15])([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1)=[O:8]|US20170071933A1_0390
8.4.2|[C:4]-[N&H1&+0&D2:3]-[C:2].[O&H1&+0&D1:1]-O>>[C:4]-[N&H1&+&D3:3](-[C:2])-[O&H0&-&D1:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[C:9](=[O:10])[NH:11][CH:12]1[CH2:13][CH2:14][N:15]([CH2:16][CH2:17]1)[CH2:18][CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1)[Cl:25])[NH:26][C:27]([CH3:28])=[O:29].[OH:30]O>CC(=O)O>[CH3:28][C:27](=[O:29])[NH:26][c:5]1[cH:4][c:3]([c:8]([cH:7][c:6]1[Cl:25])[C:9](=[O:10])[NH+:11]([O-:30])[CH:12]1[CH2:13][CH2:14][N:15]([CH2:16][CH2:17]1)[CH2:18][CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1)[O:2][CH3:1]|US20110318417A1_0281
9.7.219|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[S&H0&-&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:1]-[C:2]|[CH3:1][C@@:2]12[CH2:3][CH2:4][C@H:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@@:14]1([C@H:15]([CH2:16][CH2:17][C@@H:18]21)[C:19](=[O:20])[CH2:21]Br)[CH3:22])=[O:23])[OH:24].N#C[S-].[N:25]#[C:26][S-:27].[Ba+2]>O.CC(C)=O>[CH3:1][C@@:2]12[CH2:3][CH2:4][C@H:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@:14]1([C@H:18]2[CH2:17][CH2:16][C@@H:15]1[C:19](=[O:20])[CH2:21][S:27][C:26]#[N:25])[CH3:22])=[O:23])[OH:24]|US20120071505A1_0168
1.2.2|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[n:1]>>[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[n:1]|[CH3:1][S:2][c:3]1[n:4][n:5][c:6]([c:7]([n:8]1[NH2:9])=[O:10])[CH:11]([CH3:12])[CH2:13][CH3:14].[CH3:15][CH:16]([CH3:17])[CH:18]=O>O.Cc1ccc(cc1)S(=O)(=O)O.O=C(O[Na])O[Na].ClCCl>[CH3:1][S:2][c:3]1[n:4][n:5][c:6]([c:7]([n:8]1[N:9]=[CH:18][CH:16]([CH3:15])[CH3:17])=[O:10])[CH:11]([CH3:12])[CH2:13][CH3:14]|US20060258659A1_0396
1.2.2|[C:4]-[N&H2&+0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[O:9][CH3:10])[N+:11]([O-:12])=[O:13])[CH:14]=O.[NH2:15][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1>CCO.CC(=O)O>[CH3:10][O:9][c:8]1[cH:7][c:6]([c:5]([cH:4][c:3]1[O:2][CH3:1])[CH:14]=[N:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[N+:11]([O-:12])=[O:13]|EP2864336B1_0251
1.7.9|[C:4]=[C&H1&+0&D2:3]-Cl.[O&H1&+0&D1:2]-[c:1]>>[C:4]=[C&H1&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[F:16])-[c:17]1[cH:18][c:19]([c:20]([c:21]([cH:22]1)[F:23])[C:24]([F:25])([F:26])[O:27][c:28]1[cH:29][c:30]([c:31]([c:32]([cH:33]1)[F:34])[OH:35])[F:36])[F:37].[F:38][C:39]([F:40])([F:41])/[CH:42]=[CH:43]\Cl>CN1CCCC1=O.[NaH]>[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[F:16])-[c:17]1[cH:18][c:19]([c:20]([c:21]([cH:22]1)[F:23])[C:24]([F:26])([F:25])[O:27][c:28]1[cH:29][c:30]([c:31]([c:32]([cH:33]1)[F:34])[O:35]/[CH:43]=[CH:42]\[C:39]([F:38])([F:40])[F:41])[F:36])[F:37]|US09228129B2_0071
1.6.4|[C:4]-[C&H2&+0&D2:3]-Cl.[N&H2&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[Cl:8])[NH2:9])[N+:10]([O-:11])=[O:12].[OH:13][CH2:14][CH2:15]Cl>O.O[Na]>[NH2:9][c:5]1[cH:6][c:7]([c:2]([cH:3][c:4]1[N+:10]([O-:11])=[O:12])[NH:1][CH2:15][CH2:14][OH:13])[Cl:8]|US20080058309A1_0299
1.8.13|[O:4]-[C&H2&+0&D2:3]-Cl.[S&H1&+0&D1:2]-[c:1]>>[O:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][CH2:4]Cl.[NH2:5][c:6]1[cH:7][c:8]([cH:9][cH:10][c:11]1[N+:12]([O-:13])=[O:14])[SH:15]>O.CN(C)C=O.[NaH]>[CH3:1][CH2:2][O:3][CH2:4][S:15][c:8]1[cH:9][cH:10][c:11]([c:6]([cH:7]1)[NH2:5])[N+:12]([O-:13])=[O:14]|US20090325924A1_0194
1.2.10|[C&H2&+0&D1:4]=O.[C:3]-[N&H2&+&D2:2]-[C:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[Cl-].[CH2:1]=O.[CH3:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH:12]1[CH2:13][CH2:14][NH2+:15][CH2:16][CH2:17]1>O.[Na+].CC(=O)O.N#C[BH3-].C1CCOC1>[CH3:2][O:3][C:4](=[O:5])[c:6]1[cH:11][cH:10][c:9]([cH:8][cH:7]1)[CH:12]1[CH2:17][CH2:16][N:15]([CH2:14][CH2:13]1)[CH3:1]|US20130072473A1_0196
1.6.4|[C:4]-[C&H2&+0&D2:3]-Cl.[N&H2&+0&D1:2]-[S:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[S:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([CH2:7][CH2:8][CH2:9]Cl)[O:10][C:11]([CH3:12])=[O:13].[CH3:14][S:15]([NH2:16])(=[O:17])=[O:18]>c1ccccc1.CN(C)C=O.[NaH]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([CH2:7][CH2:8][CH2:9][NH:16][S:15]([CH3:14])(=[O:17])=[O:18])[O:10][C:11]([CH3:12])=[O:13]|US20130029970A1_0711
1.8.8|[C:4]-[S&H1&+0&D1:3].[c:2]-[S&H0&+0&D2:1]-Cl>>[C:4]-[S&H0&+0&D2:3]-[S&H0&+0&D2:1]-[c:2]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[C:10]([Cl:11])([Cl:12])[Cl:13])[S:14]Cl.[CH3:15][CH2:16][CH2:17][CH2:18][SH:19]>CCOCC>[CH3:15][CH2:16][CH2:17][CH2:18][S:19][S:14][c:7]1[cH:6][cH:5][c:4]([cH:9][c:8]1[C:10]([Cl:11])([Cl:12])[Cl:13])[N+:2]([O-:1])=[O:3]|US20180362644A1_0651
1.8.13|[N:4]-[C&H2&+0&D2:3]-Cl.[S&H1&+0&D1:2]-[c:1]>>[N:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[SH:16].[O:17]=[C:18]1[c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[C:25]([N:26]1[CH2:27]Cl)=[O:28]>CC(C)=O.O[K].O>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[S:16][CH2:27][N:26]1[C:25]([c:24]2[cH:23][cH:22][cH:21][cH:20][c:19]2[C:18]1=[O:17])=[O:28]|EP0612729A2_0394
1.7.9|[C:4]-[O&H1&+0&D1:3].[P:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[P:2]|[CH3:1][O:2][c:3]1[c:4]([c:5]2[CH2:6][O:7][C:8]([c:9]2[c:10]([c:11]1[CH2:12][CH2:13][OH:14])[O:15][CH2:16][CH2:17][Si:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])[CH3:23].[CH3:24][CH:25]([CH3:26])[O:27][P:28](=[O:29])([CH2:30]Br)[O:31][CH:32]([CH3:33])[CH3:34]>CN(C)C=O.CC(C)(C)[O-].[Li+]>[CH3:24][CH:25]([CH3:26])[O:27][P:28](=[O:29])([CH2:30][O:14][CH2:13][CH2:12][c:11]1[c:3]([c:4]([c:5]2[CH2:6][O:7][C:8]([c:9]2[c:10]1[O:15][CH2:16][CH2:17][Si:18]([CH3:19])([CH3:20])[CH3:21])=[O:22])[CH3:23])[O:2][CH3:1])[O:31][CH:32]([CH3:33])[CH3:34]|US20200115404A1_0744
2.6.2|[C:4]-[O&H1&+0&D1:3].[O:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[O:2]|[CH3:1][C:2]1[S:3][C@@H:4]2[CH2:5][C:6]([N:7]2[C:8]=1[C:9](=[O:10])[OH:11])=[O:12].[CH3:13][C:14]([CH3:15])([CH3:16])[C:17](=[O:18])[O:19][CH2:20]Br>CCN(CC)CC.CN(C)C=O>[CH3:1][C:2]1[S:3][C@@H:4]2[CH2:5][C:6]([N:7]2[C:8]=1[C:9](=[O:10])[O:11][CH2:20][O:19][C:17](=[O:18])[C:14]([CH3:13])([CH3:15])[CH3:16])=[O:12]|US08481044B2_0732
1.7.9|[N:4]-[C&H2&+0&D2:3]-Cl.[O&H1&+0&D1:2]-[c:1]>>[N:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[N:5]([CH2:6]Cl)[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[Cl:13].[OH:14][c:15]1[cH:16][cH:17][c:18]([cH:19][c:20]1[Cl:21])[Cl:22]>CCN(CC)CC.c1ccccc1>[CH3:1][O:2][C:3](=[O:4])[N:5]([CH2:6][O:14][c:15]1[cH:16][cH:17][c:18]([cH:19][c:20]1[Cl:21])[Cl:22])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[Cl:13]|US20050228017A1_0075
2.8.6|[C:4]-[O&H1&+0&D1:3].[S:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[S:2]|[N:1]#[C:2][S:3][CH2:4]Cl.[OH:5][C:6](=[S:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14]>O.CO>[N:1]#[C:2][S:3][CH2:4][O:5][C:6](=[S:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14]|EP1571154A1_0088
2.6.2|[C:4]-[O&H1&+0&D1:3].[O:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[O:2]|[CH3:1][C@:2]12[CH2:3][C:4]([C@H:5]3[C@@H:6]([CH2:7][CH2:8][C@H:9]4[CH2:10][C@@H:11]([CH2:12][CH2:13][C@@:14]43[CH3:15])[OH:16])[C@@H:17]1[CH2:18][CH2:19][C@@H:20]2[C:21](=[O:22])[OH:23])=[O:24].[CH3:25][C:26](=[O:27])[O:28][CH2:29]Cl>CCCC[N+](CCCC)(CCCC)CCCC.O=C(O)O[K].CC(C)=O.I[Na].[OH-]>[CH3:25][C:26](=[O:27])[O:28][CH2:29][O:23][C:21](=[O:22])[C@H:20]1[CH2:19][CH2:18][C@H:17]2[C@@H:6]3[CH2:7][CH2:8][C@H:9]4[CH2:10][C@@H:11]([CH2:12][CH2:13][C@@:14]4([C@H:5]3[C:4]([CH2:3][C@:2]12[CH3:1])=[O:24])[CH3:15])[OH:16]|US20120108640A1_0156
1.8.12|[C:4]-[S&H1&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[ClH:1].[NH2:2][CH2:3][CH2:4][SH:5].Br[CH2:6][c:7]1[cH:8][cH:9][s:10][n:11]1>CCO.[Na]>[ClH:1].[NH2:2][CH2:3][CH2:4][S:5][CH2:6][c:7]1[cH:8][cH:9][s:10][n:11]1|US09090573B2_1113
1.6.2|[C:4]-[N&H2&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[NH2:1][CH2:2][CH2:3][NH2:4].Br[CH2:5][c:6]1[cH:7][cH:8][s:9][n:10]1>>[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][c:6]1[cH:7][cH:8][s:9][n:10]1|US20200055839A1_0382
10.1.1|[Br&H0&-&D0:4].[c:3]:[c&H1&+0&D2:2]:[c:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[OH:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[OH:8].C1COCCO1.[Br-:9].[Br-]>CCOCC>[OH:8][c:7]1[cH:6][cH:5][c:4]([cH:3][c:2]1[OH:1])[Br:9]|US20190322675A1_0458
1.6.2|[C:4]-[C&H2&+0&D2:3]-Br.[N&H2&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH2:8])[CH3:9].[O:10]=[CH:11][CH2:12]Br>O=C(O[Na])O[Na]>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH:8][CH2:12][CH:11]=[O:10])[CH3:9]|US20110046147A1_0090
1.6.2|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[N&H2&+0&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:1]-[C:2]|[CH2:1]=[CH:2][CH2:3][CH2:4][NH2:5].[O:6]=[CH:7][CH2:8][CH2:9]Br>CO.O[Na]>[CH2:1]=[CH:2][CH2:3][CH2:4][NH:5][CH2:9][CH2:8][CH:7]=[O:6]|US10144706B2_0282
1.7.9|[N:4]-[C&H2&+0&D2:3]-Br.[O&H1&+0&D1:2]-[c:1]>>[N:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[S:9]([N:10]1[CH2:11]Br)(=[O:12])=[O:13].[O:14]=[c:15]1[c:16]([c:17]([n:18][c:19]2[cH:20][cH:21][cH:22][cH:23][n:24]21)[OH:25])[Cl:26]>O.CN1N=C(CCCCCCN1)C1=CCCCCCCCC1.CN(C)C=O>[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[S:9]([N:10]1[CH2:11][O:25][c:17]1[n:18][c:19]2[cH:20][cH:21][cH:22][cH:23][n:24]2[c:15]([c:16]1[Cl:26])=[O:14])(=[O:12])=[O:13]|US20030114449A1_0075
1.6.4|[C:4]-[N&H2&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[ClH:1].[NH2:2][CH:3]1[CH2:4][CH2:5][C:6]2([CH2:7][CH2:8]1)[CH2:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[CH2:17]2.[O:18]=[C:19]([CH2:20][CH2:21][CH2:22]Cl)[c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29]>CN(C)C=O.O=C(O[K])O[K].I[K]>[ClH:1].[O:18]=[C:19]([CH2:20][CH2:21][CH2:22][NH:2][CH:3]1[CH2:4][CH2:5][C:6]2([CH2:9][CH2:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3[CH2:17]2)[CH2:7][CH2:8]1)[c:23]1[cH:28][cH:27][c:26]([cH:25][cH:24]1)[F:29]|US10202386B2_0273
10.1.1|[Br&H0&-&D0:4].[C:3]-[C&H2&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[O:1]=[C:2]1[CH2:3][CH2:4][c:5]2[cH:6][cH:7][c:8]([c:9]([c:10]12)[Cl:11])[Cl:12].[Br-:13].[Br-].[Cu+2]>O=C1c2cccc(c2CC1Br)F.C1COCCO1>[O:1]=[C:2]1[c:10]2[c:9]([c:8]([cH:7][cH:6][c:5]2[CH2:4][CH:3]1[Br:13])[Cl:12])[Cl:11]|US20170050980A1_0877
1.6.4|[C:4]-[N&H2&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[NH2:1][CH2:2][CH2:3][NH2:4].Cl[CH2:5][c:6]1[cH:7][n:8][cH:9][cH:10][n:11]1>>[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][c:6]1[cH:7][n:8][cH:9][cH:10][n:11]1|US04022797A
1.8.12|[C:4]-[C&H2&+0&D2:3]-Br.[S&H1&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][CH2:4][CH2:5]Br.[SH:6][c:7]1[n:8][cH:9][nH:10][n:11]1>CCO.c1cn[nH]n1.[Na]>[CH3:1][CH2:2][O:3][CH2:4][CH2:5][S:6][c:7]1[n:8][cH:9][nH:10][n:11]1|EP3013796B9_0187
1.7.9|[C:4]-[C&H2&+0&D2:3]-Br.[O&H1&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[OH:1][c:2]1[cH:3][cH:4][c:5]2[O:6][CH2:7][O:8][c:9]2[cH:10]1.[Br:11][CH2:12][CH:13]=[CH:14][CH2:15]Br>COCCOC.[Na]>[Br:11][CH2:12][CH:13]=[CH:14][CH2:15][O:1][c:2]1[cH:3][cH:4][c:5]2[O:6][CH2:7][O:8][c:9]2[cH:10]1|EP0947494A1_0057
1.7.9|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[O&H1&+0&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2](=[CH:3][CH2:4]Br)[CH2:5][Br:6].[OH:7][CH2:8][c:9]1[cH:10][cH:11][c:12]2[O:13][CH2:14][O:15][c:16]2[cH:17]1>COCCOC.[Na]>[CH3:1][C:2](=[CH:3][CH2:4][O:7][CH2:8][c:9]1[cH:10][cH:11][c:12]2[O:13][CH2:14][O:15][c:16]2[cH:17]1)[CH2:5][Br:6]|EP2981535B1_0506
1.8.13|[C:4]-[S&H1&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH:2]([CH3:3])[O:4][CH2:5][CH2:6][CH:7]=[CH:8][CH2:9][SH:10].Cl[CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18]>CCO.O[Na]>[CH3:1][CH:2]([CH3:3])[O:4][CH2:5][CH2:6][CH:7]=[CH:8][CH2:9][S:10][CH2:11][c:12]1[cH:17][cH:16][c:15]([cH:14][cH:13]1)[Cl:18]|US07517996B2_0537
1.7.9|[C:4]-[C&H2&+0&D2:3]-Cl.[O&H1&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=[O:9])[CH2:10]Cl.[OH:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[F:18]>O=C(O[K])O[K]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=[O:9])[CH2:10][O:11][c:12]1[cH:17][cH:16][c:15]([cH:14][cH:13]1)[F:18]|EP1382603A1_1769
2.6.2|[C:4]-[O&H1&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH:2]([CH3:3])[CH2:4][C@@H:5]([OH:6])[C:7](=[O:8])[OH:9].Cl[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>CCN(CC)CC.C1COCCO1>[CH3:1][CH:2]([CH3:3])[CH2:4][C@@H:5]([OH:6])[C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US20060194847A1_0137
2.8.5|[C:4]-[S&H1&+0&D1:3].[O:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[O:2]|[CH3:1][C:2](=[O:3])[SH:4].[O-:5][N+:6](=[O:7])[CH2:8][CH2:9][O:10][CH2:11]Cl>c1ccncc1.C1CCOC1>[CH3:1][C:2](=[O:3])[S:4][CH2:11][O:10][CH2:9][CH2:8][N+:6]([O-:5])=[O:7]|EP0473387A2_0081
2.6.2|[C:4]-[O&H1&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C@:2]1([CH2:3][S:4][C@@H:5]2[C@@H:6]([C:7]([N:8]2[C@H:9]1[C:10](=[O:11])[OH:12])=[O:13])[NH:14][C:15](=[O:16])[CH2:17][O:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[Cl:25].[O-:26][N+:27](=[O:28])[c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[CH2:35]Br>CCN(CC)CC.CN(C)C=O.O>[CH3:1][C@:2]1([CH2:3][S:4][C@@H:5]2[C@@H:6]([C:7]([N:8]2[C@H:9]1[C:10](=[O:11])[O:12][CH2:35][c:32]1[cH:31][cH:30][c:29]([cH:34][cH:33]1)[N+:27]([O-:26])=[O:28])=[O:13])[NH:14][C:15](=[O:16])[CH2:17][O:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[Cl:25]|US20080045521A1_1721
1.8.12|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[S&H1&+0&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][CH2:11][CH:12]=[C:13]([CH3:14])[CH2:15]Br.[SH:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>CN(C)C=O.[Na]>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][CH2:11][CH:12]=[C:13]([CH3:14])[CH2:15][S:16][CH2:17][c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1|EP3013796B9_0448
1.7.9|[C:4]-[O&H1&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH:2]([CH3:3])[O:4][CH2:5][CH2:6][C:7]([CH3:8])=[CH:9][CH2:10]Cl.[OH:11][CH2:12][c:13]1[cH:14][cH:15][c:16]2[O:17][CH2:18][O:19][c:20]2[cH:21]1>c1ccccc1.O[Na].O>[CH3:8][C:7](=[CH:9][CH2:10][O:11][CH2:12][c:13]1[cH:14][cH:15][c:16]2[O:17][CH2:18][O:19][c:20]2[cH:21]1)[CH2:6][CH2:5][O:4][CH:2]([CH3:1])[CH3:3]|EP2408767B1_0192
1.8.13|[C:4]-[S&H1&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH:2]([CH3:3])[O:4][CH2:5][CH2:6][CH:7]=[CH:8][CH2:9]Cl.[SH:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18]>CC(C)(C)[O-].CC(C)(C)O.[K+]>[CH3:1][CH:2]([CH3:3])[O:4][CH2:5][CH2:6][CH:7]=[CH:8][CH2:9][S:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18]|US20200317693A1_0167
1.1.7|[C&H3&+0&D1:4]-I.[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C&H3&+0&D1:4]-[n&H0&+&D3:2](:[c:3]):[c:1]|[I-:1].[CH3:2]I.[O:3]=[CH:4][NH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[CH2:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1.c1cc[nH+]cc1>CC(C)=O>[I-:1].[CH3:2][n+:19]1[cH:18][cH:17][cH:16][cH:15][c:14]1[CH2:13][CH2:12][c:11]1[cH:10][cH:9][cH:8][cH:7][c:6]1[NH:5][CH:4]=[O:3]|US05391743A
1.8.13|[C:4]-[C&H2&+0&D2:3]-Cl.[S&H1&+0&D1:2]-[c:1]>>[C:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[ClH:1].[OH:2][CH:3]([CH2:4][N:5]([CH:6]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)[CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1)[CH2:18]Cl.[SH:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>CCO.[Na]>[ClH:1].[OH:2][CH:3]([CH2:4][N:5]([CH:6]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)[CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1)[CH2:18][S:19][c:20]1[cH:25][cH:24][cH:23][cH:22][cH:21]1|US10130634B2_0193
2.6.2|[C:4]-[O&H1&+0&D1:3].[N:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[N:2]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][C:6]1[CH2:7][S:8][CH:9]2[CH:10]([C:11]([N:12]2[C:13]=1[C:14](=[O:15])[OH:16])=[O:17])[NH2:18].[CH3:19][CH2:20][O:21][C:22](=[O:23])[N:24]([CH3:25])[CH2:26]Cl>O.CN(C)C=O.[Na]>[CH3:1][C:2](=[O:3])[O:4][CH2:5][C:6]1[CH2:7][S:8][CH:9]2[CH:10]([C:11]([N:12]2[C:13]=1[C:14](=[O:15])[O:16][CH2:26][N:24]([CH3:25])[C:22](=[O:23])[O:21][CH2:20][CH3:19])=[O:17])[NH2:18]|US20120065199A1_0212
3.11.91|[C&H3&+0&D1:4]-I.[C:3]-[C&H2&+0&D2:2]-[n:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[n:1]|[ClH:1].[CH3:2][C:3]([CH3:4])([CH2:5][F:6])[C:7](=[O:8])[CH2:9][n:10]1[cH:11][n:12][cH:13][n:14]1.[CH3:15]I>O.CS(C)=O.O[K]>[ClH:1].[CH3:2][C:3]([CH3:4])([CH2:5][F:6])[C:7](=[O:8])[CH:9]([CH3:15])[n:10]1[cH:11][n:12][cH:13][n:14]1|US10577390B2_0565
8.1.5|[C:4]-[C&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]>>[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]|[OH:1][CH:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[CH:9]1[CH2:10][CH2:11][CH2:12][CH:13]1[c-:14]1[cH:15][cH:16][cH:17][cH:18]1.[cH:19]1[cH:20][cH:21][cH-:22][cH:23]1.[Fe+2:24]>Cl[Ca]Cl>[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[CH:9]1[CH2:10][CH2:11][CH2:12][CH:13]1[c-:14]1[cH:15][cH:16][cH:17][cH:18]1.[cH:19]1[cH:20][cH:21][cH-:22][cH:23]1.[Fe+2:24]|US07030116B2_0324
9.5.4|[c:4]-[C&H1&+0&D3:3](-[C&H2&+0&D2:2]-[c:1])-O>>[c:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]|O[CH:1]([CH2:2][c:3]1[cH:4][cH:5][cH:6][n:7][cH:8]1)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>Cl.CC(=O)O>[CH:2](=[CH:1][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[c:3]1[cH:8][n:7][cH:6][cH:5][cH:4]1|US08178522B2_0725
3.9.12|[C:4]-[C&H1&+0&D2:3]=C.[S:2]-[C&H1&+0&D2:1]=C>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:1]-[S:2]|C=[CH:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][Si:7]([CH3:8])([CH3:9])[C:10]([CH3:11])([CH3:12])[CH3:13].C=[CH:14][S:15](=[O:16])(=[O:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>Cc1ccccc1>[CH3:11][C:10]([CH3:12])([CH3:13])[Si:7]([CH3:8])([CH3:9])[O:6][CH2:5][CH2:4][CH2:3][CH2:2][CH:1]=[CH:14][S:15](=[O:16])(=[O:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20170073326A1_0626
1.7.9|[O&H1&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-I>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10]I.[O:11]=[c:12]1[c:13]([cH:14][o:15][c:16]2[cH:17][c:18]([cH:19][cH:20][c:21]12)[OH:22])-[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>CC(C)=O.O=C(O[K])O[K]>[O-:1][N+:2](=[O:3])[c:4]1[cH:9][cH:8][c:7]([cH:6][cH:5]1)[CH2:10][O:22][c:18]1[cH:19][cH:20][c:21]2[c:16]([cH:17]1)[o:15][cH:14][c:13]([c:12]2=[O:11])-[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|US20200407366A1_0487
9.5.4|[C:4]-[C&H1&+0&D3:3](-[C&H2&+0&D2:2]-[S:1])-O>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[S:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH:5](O)[CH2:6][S:7](=[O:8])(=[O:9])[N:10]([c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[O:17][CH2:18][O:19][CH3:20])[C:21]([F:22])([F:23])[F:24])[CH:25]([CH3:26])[CH3:27]>C1=CN2CCCCC2CNC1.CS(=O)(=O)Cl.ClCCl.Cl>[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]=[CH:6][S:7](=[O:8])(=[O:9])[N:10]([c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[O:17][CH2:18][O:19][CH3:20])[C:21]([F:22])([F:23])[F:24])[CH:25]([CH3:26])[CH3:27]|US07485644B2_0215
3.9.12|[C:4]-[C&H1&+0&D2:3]=C.[C:2]-[C&H1&+0&D2:1]=C>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:1]-[C:2]|C=[CH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].C=[CH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH3:18])[CH3:19]>CCCCCCCCCCC1OC1CCCCC(C)C>[CH3:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH:1]=[CH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH3:18])[CH3:19]|US20190314799A1_0316
10.1.4|[C:4]-[C&H2&+0&D2:3]-[C:2].[I&H0&+0&D1:1]-I>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[I&H0&+0&D1:1]|[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[NH:12]1)[F:13].[I:14]I>CCN(CC)CC.O=S(O[Na])O[Na].C[Si](C)(C)I.C1CCOC1.ClCCl>[O:1]=[C:2]1[NH:12][c:11]2[cH:10][cH:9][c:8]([cH:7][c:6]2[CH2:5][CH2:4][CH:3]1[I:14])[F:13]|US20190241565A1_0384
1.2.2|[N&H2&+0&D1:4]-[S:3].[N:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:4](-[S:3])=[C&H1&+0&D2:1]-[N:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[S:9]([NH2:10])(=[O:11])=[O:12])[C:13]([CH3:14])([CH3:15])[CH3:16].[CH3:17][N:18]([CH3:19])[CH:20]=O>COC(OC)N(C)C.O>[CH3:17][N:18]([CH3:19])[CH:20]=[N:10][S:9](=[O:11])(=[O:12])[c:8]1[cH:7][c:6]([cH:5][cH:4][c:3]1[O:2][CH3:1])[C:13]([CH3:14])([CH3:15])[CH3:16]|US07671063B2_0133
8.2.1|[O&H1&+0&D1:4]-O.[c:3]-[S&H0&+0&D2:2]-[c:1]>>[O&H0&+0&D1:4]=[S&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][c:8]([cH:9][c:10]([c:11]1[S:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[S:19]([NH2:20])(=[O:21])=[O:22])[C:23](=[O:24])[OH:25].O[OH:26]>CC(=O)O>[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][c:8]([cH:9][c:10]([c:11]1[S:12](=[O:26])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[S:19]([NH2:20])(=[O:21])=[O:22])[C:23](=[O:24])[OH:25]|US06077850A
3.11.34|[C&H2&+0&D1:4]=O.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C&H2&+0&D1:4]=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH2:1]=O.[Cl:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[Cl:9])[CH2:10][N:11]1[CH2:12][CH2:13][N:14]=[C:15]1[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O.CN(C)C=O.[NaH]>[CH2:1]=[C:16]([C:15]1=[N:14][CH2:13][CH2:12][N:11]1[CH2:10][c:6]1[cH:5][cH:4][c:3]([cH:8][c:7]1[Cl:9])[Cl:2])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|EP1791901B1_0139
1.2.2|[N&H2&+0&D1:4]-[O:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:4](\[O:3])=[C&H1&+0&D2:1]/[c:2]|Cl.[CH3:1][O:2][NH2:3].[O-:4][N+:5](=[O:6])[c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[CH:13]=O)[O:14][CH2:15][C:16](=[O:17])[OH:18]>>[CH3:1][O:2]/[N:3]=[CH:13]/[c:11]1[cH:12][c:7]([cH:8][cH:9][c:10]1[O:14][CH2:15][C:16](=[O:17])[OH:18])[N+:5]([O-:4])=[O:6]|US20050113450A1_0173
9.5.4|[C:4]-[C&H2&+0&D2:3]-[C&H1&+0&D3:2](-[c:1])-O>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])[O:4][CH2:5][CH2:6][CH:7]([CH3:8])[CH2:9][CH2:10][CH:11](O)[c:12]1[cH:13][cH:14][c:15]2[O:16][CH2:17][O:18][c:19]2[cH:20]1>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1.O>[CH3:8][CH:7]([CH2:6][CH2:5][O:4][CH:2]([CH3:1])[CH3:3])[CH2:9][CH:10]=[CH:11][c:12]1[cH:13][cH:14][c:15]2[O:16][CH2:17][O:18][c:19]2[cH:20]1|EP0207581B1_0430
8.2.1|[C:4]-[S&H0&+0&D2:3]-[c:2].[O&H1&+0&D1:1]-O>>[C:4]-[S&H0&+0&D3:3](=[O&H0&+0&D1:1])-[c:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[CH2:15][CH:16]([OH:17])[CH2:18][S:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[F:26].O[OH:27]>N.O.CC(=O)O>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[CH2:15][CH:16]([OH:17])[CH2:18][S:19](=[O:27])[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[F:26]|US07253204B2_0754
1.2.2|[N&H2&+0&D1:4]-[N:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:4](-[N:3])=[C&H1&+0&D2:1]-[c:2]|Cl.[CH3:1][n:2]1[c:3]([n:4][cH:5][c:6]1[N+:7]([O-:8])=[O:9])[CH:10]=O.[NH2:11][NH:12][C:13]([NH2:14])=[O:15]>O>[CH3:1][n:2]1[c:6]([cH:5][n:4][c:3]1[CH:10]=[N:11][NH:12][C:13]([NH2:14])=[O:15])[N+:7]([O-:8])=[O:9]|US06887863B2_0144
10.1.4|[I&H0&+0&D1:4]-I.[c:3]:[c&H1&+0&D2:2]:[o:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][c:16]2[o:17][cH:18][c:19]([c:20]2[cH:21]1)[CH3:22].[I:23]I>c1ccccc1.O=[Hg]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][c:16]2[o:17][c:18]([c:19]([c:20]2[cH:21]1)[CH3:22])[I:23]|EP3484894B1_0602
3.11.2|[C&H3&+0&D1:4]-[C:3].[N:2]-[C&H1&+0&D2:1]=O>>[C&H1&+0&D2:4](-[C:3])=[C&H1&+0&D2:1]-[N:2]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][o:7][cH:8]1.[CH3:9][N:10]([CH3:11])[CH:12]=O>>[CH3:9][N:10]([CH3:11])[CH:12]=[CH:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][o:7][cH:8]1|US20080188502A1_0258
1.2.2|[N&H2&+0&D1:4]-[c:3].[N:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:4](-[c:3])=[C&H1&+0&D2:1]-[N:2]|[CH3:1][n:2]1[c:3]([cH:4][n:5][c:6]1-[c:7]1[n:8][n:9][c:10]2[cH:11][cH:12][c:13]([n:14][n:15]12)[NH2:16])[N+:17]([O-:18])=[O:19].O=[CH:20][N:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1>C1COCCO1.O=P(Cl)(Cl)Cl>[CH3:1][n:2]1[c:3]([cH:4][n:5][c:6]1-[c:7]1[n:8][n:9][c:10]2[cH:11][cH:12][c:13]([n:14][n:15]12)[N:16]=[CH:20][N:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[N+:17]([O-:18])=[O:19]|US20200190091A1_0460
9.7.255|[C:4]-[C&H2&+0&D2:3]-[C&H1&+0&D3:2](-[C:1])-I>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]|[CH3:1][C@:2]12[CH2:3][CH2:4][C@H:5]3[C@@H:6]([CH2:7][CH2:8][C:9]4=[CH:10][C:11]([CH:12]([CH2:13][C@@:14]43[CH3:15])I)=[O:16])[C@@H:17]1[CH2:18][CH2:19][C:20]2=[O:21]>O.CN(C)C=O.O=C(O[Li])O[Li]>[CH3:1][C@:2]12[CH2:3][CH2:4][C@H:5]3[C@@H:6]([CH2:7][CH2:8][C:9]4=[CH:10][C:11]([CH:12]=[CH:13][C@@:14]43[CH3:15])=[O:16])[C@@H:17]1[CH2:18][CH2:19][C:20]2=[O:21]|US07943567B2_0124
1.1.3|[C&H3&+0&D1:4]-I.[C:3]-[N&H1&+0&D2:2]-[n:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[n:1]|[CH3:1]I.[CH3:2][CH2:3][O:4][C:5](=[O:6])[NH:7][n:8]1[cH:9][cH:10][cH:11][c:12]1[C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O.CN(C)C=O.O=C(O[Na])O[Na]>[CH3:2][CH2:3][O:4][C:5](=[O:6])[N:7]([CH3:1])[n:8]1[cH:9][cH:10][cH:11][c:12]1[C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US08680121B2_0122
7.5.1|[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[O:2])-[c:1]>>[O&H1&+0&D1:4]-[C&H1&+0&D3:3](-[O:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[CH2:8][O:9][C:10]([c:11]12)=[O:12])[O:13][CH3:14]>CC(C)C[AlH]CC(C)C.Cc1ccccc1.ClC(Cl)Cl.ClCCl.CO>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[CH2:8][O:9][CH:10]([c:11]12)[OH:12])[O:13][CH3:14]|US20170008877A1_3960
1.7.9|[O&H1&+0&D1:4]-[c:3].[O:2]-[C&H2&+0&D2:1]-I>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[O:2]|[CH3:1][N:2]([CH3:3])[CH2:4][C@H:5]([c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[OH:12])[C:13]1([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[OH:19].[CH3:20][C:21]([CH3:22])([CH3:23])[C:24](=[O:25])[O:26][CH2:27]I>CC#N>[CH3:1][N:2]([CH3:3])[CH2:4][C@H:5]([c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][CH2:27][O:26][C:24](=[O:25])[C:21]([CH3:20])([CH3:22])[CH3:23])[C:13]1([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[OH:19]|US20120209000A1_0123
7.6.1|[N&+:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[N&+:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[O-:1][N+:2](=[O:3])[CH:4]=[CH:5][c:6]1[cH:7][cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[cH:15]1>[Na+].CCO.C1COCCO1.[BH4-]>[O-:1][N+:2](=[O:3])[CH2:4][CH2:5][c:6]1[cH:7][cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[cH:15]1|US05387710A
10.1.4|[C:4]=[C&H1&+0&D2:3]-[C:2].[I&H0&+0&D1:1]-I>>[C:4]=[C&H0&+0&D3:3](-[C:2])-[I&H0&+0&D1:1]|[O:1]=[C:2]1[CH:3]=[CH:4][C@H:5]2[CH2:6][O:7][C@@H:8]1[O:9]2.[I:10]I>CCOC(C)=O.c1ccncc1.ClC(Cl)(Cl)Cl>[O:1]=[C:2]1[C:3](=[CH:4][C@H:5]2[CH2:6][O:7][C@@H:8]1[O:9]2)[I:10]|US20070299092A1_0230
7.5.1|[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[O&H1&+0&D1:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[O:1]=[C:2]([OH:3])[CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([c:10]([c:11]1[Cl:12])[Cl:13])[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][s:20]1>O.[Na+].CCO.O[Na].[BH4-]>[O:1]=[C:2]([OH:3])[CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([c:10]([c:11]1[Cl:12])[Cl:13])[CH:14]([OH:15])[c:16]1[cH:17][cH:18][cH:19][s:20]1|US09295672B2_0238
3.11.91|[C&H3&+0&D1:4]-I.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8]/[CH:9]=[CH:10]\[CH2:11]/[CH:12]=[CH:13]\[CH2:14]/[CH:15]=[CH:16]\[CH2:17][CH2:18][CH2:19][C:20](=[O:21])[O:22][CH2:23][CH3:24].[CH3:25]I>CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O.CCCC[Li]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8]/[CH:9]=[CH:10]\[CH2:11]/[CH:12]=[CH:13]\[CH2:14]/[CH:15]=[CH:16]\[CH2:17][CH2:18][CH:19]([CH3:25])[C:20](=[O:21])[O:22][CH2:23][CH3:24]|US20200148705A1_1123
1.2.1|[N&H2&+0&D1:4]-[S:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H1&+0&D2:4](-[S:3])-[C&H2&+0&D2:1]-[c:2]|O=[CH:1][c:2]1[cH:3][n:4][cH:5][c:6]([cH:7]1)[Br:8].[CH3:9][S:10]([NH2:11])(=[O:12])=[O:13]>CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.CC(=O)O.[O-]C(=O)O.ClCCCl.[Na+].[Na+]>[CH3:9][S:10](=[O:12])(=[O:13])[NH:11][CH2:1][c:2]1[cH:3][n:4][cH:5][c:6]([cH:7]1)[Br:8]|EP3653618A1_0280
7.5.1|[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[O:1]>>[C:4]-[C&H1&+0&D3:3](-[O&H1&+0&D1:2])-[O:1]|[O:1]=[C:2]1[O:3][CH:4]2[CH2:5][CH:6]3[CH2:7][CH:8]([CH2:9]2)[O:10][CH:11]1[O:12]3>O.CCO.CC(=O)O.[Na]>[OH:1][CH:2]1[O:3][CH:4]2[CH2:5][CH:6]3[CH2:7][CH:8]([CH2:9]2)[O:10][CH:11]1[O:12]3|EP0577394A1_0140
1.2.1|[N&H2&+0&D1:4]-[c:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H1&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[CH:8]1[CH2:9][N:10]2[CH2:11][CH2:12][S:13][C:14]2=[N:15]1.O=[CH:16][c:17]1[cH:18][cH:19][cH:20][o:21]1>[Na+].Cl.CO.CC(=O)O.N#C[BH3-]>[cH:5]1[cH:4][cH:3][c:2]([cH:7][c:6]1[CH:8]1[CH2:9][N:10]2[CH2:11][CH2:12][S:13][C:14]2=[N:15]1)[NH:1][CH2:16][c:17]1[cH:18][cH:19][cH:20][o:21]1|US07834013B2_0217
1.1.3|[C&H3&+0&D1:4]-I.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][cH:7][cH:8][n:9][c:10]1[NH:11][c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[N+:18]([O-:19])=[O:20])[Cl:21].[CH3:22]I>CN(C)P(=O)(N(C)C)N(C)C.O.[NaH]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][cH:7][cH:8][n:9][c:10]1[N:11]([CH3:22])[c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[N+:18]([O-:19])=[O:20])[Cl:21]|US20200369676A1_1013
7.6.1|[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH2:1]=[C:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]2-[c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][c:17]2[cH:18]1>C1COCCO1.[Pd]>[CH3:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]2-[c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][c:17]2[cH:18]1|US20170334891A1_0535
1.2.9|[C&H3&+0&D1:4]-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[O:1]=[C:2]1[NH:3][CH2:4][CH:5]([O:6]1)[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[CH3:14]O>c1ccccc1.CI.[Na]>[CH3:14][N:3]1[CH2:4][CH:5]([O:6][C:2]1=[O:1])[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US08871790B2_2283
10.1.4|[I&H0&+0&D1:4]-I.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[NH:5][c:6]1[cH:7][n:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[n:14]1)[S:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[I:22]I>O.CC(=O)O.[O-][I](=O)=O.O=S(=O)(O)O.O=C(O)O[Na].[K+]>[CH3:1][O:2][C:3](=[O:4])[NH:5][c:6]1[n:14][c:13]2[cH:12][cH:11][c:10]([cH:9][n:8]2[c:7]1[I:22])[S:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|EP3204360B1_0342
1.2.1|[N&H2&+0&D1:4]-[N:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H1&+0&D2:4](-[N:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]([CH2:10][c:11]1[cH:12][nH:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21)[C:20](=[O:21])[NH:22][NH2:23].O=[CH:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>CO.[H][H].[C].[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]([CH2:10][c:11]1[cH:12][nH:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21)[C:20](=[O:21])[NH:22][NH:23][CH2:24][c:25]1[cH:30][cH:29][cH:28][cH:27][cH:26]1|US20080207695A1_0387
9.5.4|[c:4]-[C&H1&+0&D3:3](-[C&H2&+0&D2:2]-[n:1])-O>>[c:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9](O)[CH2:10][n:11]1[c:12]2[cH:13][cH:14][c:15]([cH:16][c:17]2[c:18]2[CH2:19][CH2:20][N:21]([CH2:22][CH2:23][c:24]21)[CH3:25])[Cl:26]>CCN(CC)CC.CN1CCCC1=O.CS(=O)(=O)Cl.ClCCl.O.[OH-].[K+]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]=[CH:10][n:11]1[c:12]2[cH:13][cH:14][c:15]([cH:16][c:17]2[c:18]2[CH2:19][CH2:20][N:21]([CH2:22][CH2:23][c:24]21)[CH3:25])[Cl:26]|US20150315188A1_0137
3.9.12|[C:4]-[C&H1&+0&D2:3]=C.[O:2]-[C&H1&+0&D2:1]=C>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:1]-[O:2]|C=[CH:1][CH2:2][CH2:3][CH:4]([O:5][CH:6]=C)[CH:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>Cl[Ru](Cl)(=Cc1ccccc1)([P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)[P](C1CCCCC1)(C1CCCCC1)C1CCCCC1.c1ccccc1>[CH:1]1=[CH:6][O:5][CH:4]([CH2:3][CH2:2]1)[CH:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|EP2534140B1_0156
1.7.9|[O&H0&-&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[Na+].Cl.[CH3:1][c:2]1[cH:3][s:4][c:5]2[n:6][c:7]([cH:8][n:9]12)[CH2:10]Cl.[O-:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>C1CCOC1>[CH3:1][c:2]1[cH:3][s:4][c:5]2[n:6][c:7]([cH:8][n:9]12)[CH2:10][O:11][c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|EP2248423A1_0256
1.1.3|[C&H3&+0&D1:4]-I.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&+0&D1:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]1[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=1[c:11]1[cH:12][c:13]([nH:14][n:15]1)-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[CH3:22]I>C1CCOC1.[NaH]>[CH3:1][O:2][C:3](=[O:4])[C:5]1[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=1[c:11]1[cH:12][c:13]([n:14]([n:15]1)[CH3:22])-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|EP3204360B1_0355
9.5.4|[C:4]-[C&H2&+0&D2:3]-[C&H1&+0&D3:2](-[O:1])-O>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C@@:6]1([CH2:7][CH:8]([O:9][CH:10]1[CH2:11][O:12][Si:13]([CH3:14])([CH3:15])[C:16]([CH3:17])([CH3:18])[CH3:19])O)[CH3:20]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C@@:6]1([CH:7]=[CH:8][O:9][CH:10]1[CH2:11][O:12][Si:13]([CH3:14])([CH3:15])[C:16]([CH3:17])([CH3:18])[CH3:19])[CH3:20]|US20040013779A1_0081
1.1.3|[C&H3&+0&D1:4]-I.[C:3]-[N&H1&+0&D2:2]-[O:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[O:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:13])[NH:14][O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1.[CH3:23]I>Cl.CN(C)C=O.[NaH]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12](=[O:13])[N:14]([CH3:23])[O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|EP1301472B1_0299
1.1.3|[C&H3&+0&D1:4]-I.[N:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[N:3])-[c:1]|[CH3:1][S:2][C:3]1=[N:4][C:5]([C:6]([N:7]1[NH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)=[O:15])([CH3:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1.[CH3:23]I>O.CC(C)(C)O[K].C1CCOC1>[CH3:1][S:2][C:3]1=[N:4][C:5]([C:6]([N:7]1[N:8]([CH3:23])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)=[O:15])([CH3:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US20100261711A1_0153
1.2.10|[C&H2&+0&D1:4]=O.[C:3]-[N&H1&+0&D2:2]-[N:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[N:1]|[CH2:1]=O.[O:2]=[C:3]1[CH2:4][N:5]([CH2:6][CH2:7][N:8]1[NH:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[c:16]1[cH:17][cH:18][n:19][cH:20][cH:21]1)[S:22](=[O:23])(=[O:24])[c:25]1[cH:26][cH:27][c:28]2[cH:29][c:30]([cH:31][cH:32][c:33]2[cH:34]1)[Cl:35]>O=CO.O[Na]>[CH3:1][N:9]([CH:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[c:16]1[cH:17][cH:18][n:19][cH:20][cH:21]1)[N:8]1[CH2:7][CH2:6][N:5]([CH2:4][C:3]1=[O:2])[S:22](=[O:23])(=[O:24])[c:25]1[cH:26][cH:27][c:28]2[cH:29][c:30]([cH:31][cH:32][c:33]2[cH:34]1)[Cl:35]|US20100190778A1_0275
9.5.4|[C:4]-[C&H1&+0&D3:3](-[C&H2&+0&D2:2]-[c:1])-O>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7](O)[CH2:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[C:15](=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O=P12OP3(OP(O2)(OP(O1)(O3)=O)=O)=O.Cc1ccccc1C>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]=[CH:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[C:15](=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US20130005707A1_1622
10.1.4|[I&H0&+0&D1:4]-I.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[F:8].[I:9]I>O.CCOCC.[O-]C([O-])=O.[Ca+2]>[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[I:9])[F:8]|EP3288936B1_0275
3.11.2|[C&H3&+0&D1:4]-[C:3].[c:2]-[C&H1&+0&D2:1]=O>>[C&H1&+0&D2:4](-[C:3])=[C&H1&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]([CH3:10])=[O:11].O=[CH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>[Na+].CCO.[OH-]>[CH3:1][O:2][c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[C:9](=[O:11])[CH:10]=[CH:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|EP3212189B1_0523
1.6.8|[N&H2&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-I>>[N&H1&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[O:7][C@H:8]([CH3:9])[C@H:10]1[C:11]([N:12]2[C:13](=[C:14]([CH2:15][C@H:16]12)[c:17]1[cH:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[c:25]([cH:26]1)[CH2:27]I)[C:28](=[O:29])[O:30][CH2:31][CH:32]=[CH2:33])=[O:34].[NH2:35][c:36]1[cH:37][cH:38][cH:39][cH:40][n:41]1>CC#N.[O-]S(=O)(=O)C(F)(F)F.ClCCl.[Ag+]>[CH2:33]=[CH:32][CH2:31][O:30][C:28](=[O:29])[C:13]1=[C:14]([CH2:15][C@@H:16]2[C@H:10]([C:11]([N:12]12)=[O:34])[C@@H:8]([CH3:9])[O:7][C:5](=[O:6])[O:4][CH2:3][CH:2]=[CH2:1])[c:17]1[cH:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[c:25]([cH:26]1)[CH2:27][NH:35][c:36]1[cH:37][cH:38][cH:39][cH:40][n:41]1|US09580423B2_0420
1.2.2|[N&H2&+0&D1:4]-[n:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:4](-[n:3])=[C&H1&+0&D2:1]-[c:2]|[CH3:1][c:2]1[n:3][n:4][c:5]([c:6]([n:7]1[NH2:8])=[O:9])-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.O=[CH:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1>[CH3:1][c:2]1[n:3][n:4][c:5]([c:6]([n:7]1[N:8]=[CH:16][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1)=[O:9])-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US20090105124A1_0336
3.11.2|[C&H2&+0&D1:4]=O.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H2&+0&D1:4]=[C&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([c:8]1[Cl:9])[Cl:10])[C:11](=[O:12])[CH2:13][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1.[CH2:19]=O>C1COCCO1.O=S(=O)(O)O>[CH2:19]=[C:13]([C:11](=[O:12])[c:6]1[cH:5][cH:4][c:3]([c:8]([c:7]1[Cl:10])[Cl:9])[O:2][CH3:1])[CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1|EP3335738A1_0052
7.5.1|[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:7])[CH:8]=[CH:9][C:10]1=[C:11]([C:12]([CH2:13][CH:14]1[OH:15])=[O:16])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23](=[O:24])[OH:25]>O=C(O)CC(O)(CC(=O)O)C(=O)O.CCN(CC)CC.CCO.O.[Na+].[BH4-]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([OH:7])[CH:8]=[CH:9][C:10]1=[C:11]([C:12]([CH2:13][CH:14]1[OH:15])=[O:16])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23](=[O:24])[OH:25]|US05117015A
1.1.3|[C&H3&+0&D1:4]-I.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1]I.[O:2]=[C:3]1[NH:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[C:11]2([O:12][CH2:13][CH2:14][N:15]12)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[Cl:22]>O.Cl.CN(C)C=O.[NaH]>[CH3:1][N:4]1[C:3]([N:15]2[CH2:14][CH2:13][O:12][C:11]2([c:10]2[cH:9][c:8]([cH:7][cH:6][c:5]21)[Cl:22])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)=[O:2]|EP3319955B1_0221
8.1.10|[O&H1&+0&D1:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]>>[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]|[OH:1][CH:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][n:20]1>O=[Cr](=O)=O.ClCCl.c1ccncc1>[O:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][n:20]1|EP2479168B1_0634
8.1.13|[C:4]-[C&H1&+0&D3:3](-[C:2])-[O&H1&+0&D1:1]>>[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:12]([CH2:13][CH:14]([C:15]=1[CH:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[OH:24])=[O:25]>O.O=[Cr](=O)=O.c1ccncc1>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:12]([CH2:13][C:14]([C:15]=1[CH:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)=[O:24])=[O:25]|US20190344252A1_0033
3.3.4|[C&H1&+0&D1:4]#[C:3].[C:2]=[C&H1&+0&D2:1]-I>>[C&H0&+0&D2:4](#[C:3])-[C&H1&+0&D2:1]=[C:2]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[O:9]=[C:10]1[CH2:11][CH2:12]/[C:13]([O:14]1)=[CH:15]\I.[Cu+]>CCN(C=O)CC>[O:9]=[C:10]1[CH2:11][CH2:12]/[C:13]([O:14]1)=[CH:15]\[C:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|US20100216817A1_0075
3.11.2|[C&H3&+0&D1:4]-[C:3].[C:2]-[C&H1&+0&D2:1]=O>>[C&H1&+0&D2:4](-[C:3])=[C&H1&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])=[O:4].[CH3:5][CH:6]([CH2:7][CH:8]=O)[CH2:9][CH2:10][CH2:11][C:12]([CH3:13])([CH3:14])[OH:15]>C#C>[CH3:1][C:2](=[O:4])[CH:3]=[CH:8][CH2:7][CH:6]([CH3:5])[CH2:9][CH2:10][CH2:11][C:12]([CH3:13])([CH3:14])[OH:15]|US08809538B2_1876
1.2.2|[N&H2&+0&D1:4]-[O:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:4](-[O:3])=[C&H1&+0&D2:1]-[c:2]|[NH2:1][O:2][CH2:3][C:4](=[O:5])[OH:6].O=[CH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14]>[Na+].CCO.CC([O-])=O>[O:5]=[C:4]([OH:6])[CH2:3][O:2][N:1]=[CH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14]|EP0589039A1_0042
10.1.4|[I&H0&+0&D1:4]-I.[n:3]:[c&H1&+0&D2:2]:[o:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[o:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][cH:8][o:9][c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[I:17]I>C[Si](C)(C)[N-][Si](C)(C)C.CCOC(C)=O.C1CCOC1.[Li+]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][c:8]([o:9][c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[I:17]|EP1435951B1_0128
7.5.1|[N:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[N:4]-[C&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[C:6]([N:7]([C:8]([c:9]2[cH:10][c:11]1[O:12][CH3:13])=[O:14])[CH2:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:23]>C1COCCO1.CO.O.[BH4-].[K+]>[CH3:13][O:12][c:11]1[cH:10][c:9]2[C:8]([N:7]([CH:6]([c:5]2[cH:4][c:3]1[O:2][CH3:1])[OH:23])[CH2:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:14]|US08710261B2_0499
1.2.1|[N&H2&+0&D1:4]-[O:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H1&+0&D2:4](-[O:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[CH:9]=O)[O:10][CH3:11])[O:12][CH2:13][CH2:14][CH2:15][C:16](=[O:17])[OH:18].[NH2:19][O:20][CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][O:26]1>COC(OC)OC.C1CCOC1.CC(=O)O.N#C[BH3-].[Na+]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[CH2:9][NH:19][O:20][CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][O:26]1)[O:10][CH3:11])[O:12][CH2:13][CH2:14][CH2:15][C:16](=[O:17])[OH:18]|US20130102600A1_0159
10.1.4|[C:4]-[N&H1&+0&D2:3]-[C:2].[I&H0&+0&D1:1]-I>>[C:4]-[N&H0&+0&D3:3](-[C:2])-[I&H0&+0&D1:1]|[CH3:1][C:2]1([CH2:3][O:4][C:5]([NH:6]1)=[O:7])[CH3:8].[I:9]I>CC(=O)O[I](OC(C)=O)c1ccccc1.Ic1ccccc1>[CH3:1][C:2]1([CH2:3][O:4][C:5]([N:6]1[I:9])=[O:7])[CH3:8]|US09637462B2_0235
7.5.1|[C:4]-[C&H0&+0&D3:3](-[N:2])=[O&H0&+0&D1:1]>>[C:4]-[C&H1&+0&D3:3](-[N:2])-[O&H1&+0&D1:1]|[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([C:6]([NH:7]1)=[O:8])[C@@H:9]1[O:10][C@@H:11]([C@H:12]([C@H:13]1[OH:14])[OH:15])[CH2:16][OH:17]>O.[Na+].[BH4-]>[O:8]=[C:6]1[NH:7][CH:2]([CH2:3][CH2:4][N:5]1[C@@H:9]1[O:10][C@@H:11]([C@H:12]([C@H:13]1[OH:14])[OH:15])[CH2:16][OH:17])[OH:1]|US20200277259A1_0766
1.1.3|[C&H3&+0&D1:4]-I.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]1[NH:3][C:4]([O:5][C:6]11[CH2:7][CH2:8][CH2:9][CH2:10][CH:11]1[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)=[O:18].[CH3:19]I>CN(C)P(=O)(N(C)C)N(C)C.N[Na].N.O>[CH3:1][CH:2]1[N:3]([C:4]([O:5][C:6]11[CH2:7][CH2:8][CH2:9][CH2:10][CH:11]1[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)=[O:18])[CH3:19]|US10246422B2_0808
7.6.1|[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[O:2])-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:3](-[O:2])-[c:1]|[CH2:1]=[C:2]([O:3][C:4]([CH3:5])=[O:6])[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1>CO.F[B-](F)(F)F.[H][H]>[CH3:5][C:4](=[O:6])[O:3][CH:2]([CH3:1])[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1|US20090042854A1_0161
10.1.4|[I&H0&+0&D1:4]-I.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][c:2]1[cH:3][cH:4][s:5][c:6]1[CH2:7][OH:8].[I:9]I>c1ccccc1.O=[Hg]>[CH3:1][c:2]1[cH:3][c:4]([s:5][c:6]1[CH2:7][OH:8])[I:9]|EP2886545A1_0537
3.9.18|[C&H1&+0&D1:4]#[C:3].[C:2]#[C&H0&+0&D2:1]-I>>[C&H0&+0&D2:4](#[C:3])-[C&H0&+0&D2:1]#[C:2]|[CH:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](=[O:12])[OH:13].[CH3:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]#[C:25]I>O.Cl.Cl.CO.CCN.NO.Cl[Cu].[OH-].[K+]>[CH3:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]#[C:25][C:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](=[O:12])[OH:13]|US20060223947A1_0060
1.7.7|[O&H1&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-O>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[OH:12].O[CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>ClP(Cl)(Cl)(Cl)Cl.CCOCC.O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][CH2:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|US07022707B2_0748
1.2.4|[C&H2&+0&D1:4]=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]1([CH2:3][CH:4]([CH2:5][C:6]([NH:7]1)([CH3:8])[CH3:9])[OH:10])[CH3:11].[CH2:12]=O>O=CO.O[Na]>[CH3:1][C:2]1([CH2:3][CH:4]([CH2:5][C:6]([N:7]1[CH3:12])([CH3:8])[CH3:9])[OH:10])[CH3:11]|EP3489237B1_0292
3.11.91|[C&H3&+0&D1:4]-I.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1]I.[CH3:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][c:9]2[O:10][c:11]3[n:12][cH:13][cH:14][cH:15][c:16]3[CH2:17][c:18]2[cH:19]1>O.CC(C)O.[Na]>[CH3:2][C:3](=[O:4])[CH:5]([CH3:1])[c:6]1[cH:7][cH:8][c:9]2[O:10][c:11]3[n:12][cH:13][cH:14][cH:15][c:16]3[CH2:17][c:18]2[cH:19]1|US20190031599A1_0507
8.2.1|[C:4]-[S&H0&+0&D2:3]-[C:2].[O&H1&+0&D1:1]-O>>[C:4]-[S&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]|[CH3:1][C:2]1([CH2:3][C:4](=[C:5]([C:6]([CH2:7]1)=[O:8])[S:9][CH2:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1)[OH:17])[CH3:18].O[OH:19]>O.O.CC(=O)O>[CH3:1][C:2]1([CH2:3][C:4](=[C:5]([C:6]([CH2:7]1)=[O:8])[S:9](=[O:19])[CH2:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1)[OH:17])[CH3:18]|US10227299B2_1844
1.1.3|[C&H3&+0&D1:4]-I.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&+0&D1:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][c:8]2[n:9][c:10]3[cH:11][c:12]([c:13]([cH:14][c:15]3[cH:16][c:17]2[c:18]([nH:19]1)=[O:20])[O:21][CH3:22])[O:23][CH3:24].[CH3:25]I>O.O.CN(C)C=O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][c:8]2[n:9][c:10]3[cH:11][c:12]([c:13]([cH:14][c:15]3[cH:16][c:17]2[c:18]([n:19]1[CH3:25])=[O:20])[O:21][CH3:22])[O:23][CH3:24]|EP3204360B1_0333
10.1.1|[Br&H1&+0&D0:4].[C:3]-[C&H2&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[BrH:1].[CH3:2][CH:3]1[CH2:4][CH2:5][C:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21)=[O:13]>CCOC(C)=O.ClC(Cl)Cl.Br[Cu]Br>[CH3:2][CH:3]1[CH2:4][CH:5]([C:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21)=[O:13])[Br:1]|US20090270363A1_0594
10.1.4|[I&H0&+0&D1:4]-I.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][Si:2]([CH2:3][n:4]1[cH:5][n:6][cH:7][n:8]1)([c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[F:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22].[I:23]I>CCCCCC.CCCC[Li].C1CCOC1>[CH3:1][Si:2]([CH2:3][n:4]1[n:8][cH:7][n:6][c:5]1[I:23])([c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[F:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22]|EP2920171B1_0238
1.2.2|[N&H2&+0&D1:4]-[c:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:4](-[c:3])=[C&H1&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[O:9][CH3:10])[N+:11]([O-:12])=[O:13])[CH:14]=O.[CH3:15][CH2:16][N:17]([CH2:18][CH3:19])[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[NH2:26]>CCO.CC(=O)O>[CH3:15][CH2:16][N:17]([CH2:18][CH3:19])[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[N:26]=[CH:14][c:5]1[cH:4][c:3]([c:8]([cH:7][c:6]1[N+:11]([O-:12])=[O:13])[O:9][CH3:10])[O:2][CH3:1]|EP3613735A1_0114
10.1.1|[Br&H1&+0&D0:4].[c:3]:[c&H1&+0&D2:2]:[c:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][n:6][c:7]1[CH2:8][CH2:9][CH2:10][CH2:11][NH2:12].[BrH:13].Br>FC(Cl)(Cl)C(F)(F)Cl.O=S(=O)=O.ClCCl.Br>[CH3:1][c:2]1[cH:3][c:4]([cH:5][n:6][c:7]1[CH2:8][CH2:9][CH2:10][CH2:11][NH2:12])[Br:13]|US20200203632A1_0130
1.1.3|[C&H3&+0&D1:4]-I.[n:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&+0&D1:4]-[n&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[N:11]1[CH:12]([CH2:13][CH2:14][CH:15]1[c:16]1[n:17][n:18][nH:19][n:20]1)[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[F:27].[CH3:28]I>CC(C)=O.O=C(O[K])O[K]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[N:11]1[CH:12]([CH2:13][CH2:14][CH:15]1[c:16]1[n:17][n:18][n:19]([n:20]1)[CH3:28])[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[F:27]|EP2121687B1_0583
3.9.12|[C:4]-[C&H1&+0&D2:3]=C.[c:2]-[C&H1&+0&D2:1]=C>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:1]-[c:2]|C=[CH:1][CH2:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[CH:10]=C)[Br:11]>Cc1ccccc1.F[P-](F)(F)(F)(F)F>[Br:11][c:7]1[cH:6][cH:5][c:4]2[O:3][CH2:2][CH:1]=[CH:10][c:9]2[cH:8]1|US20190314799A1_0313
3.11.91|[C&H3&+0&D1:4]-I.[C:3]-[C&H2&+0&D2:2]-[N:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[N:1]|[CH3:1]I.[O:2]=[CH:3][NH:4][CH2:5][C:6](=[O:7])[c:8]1[n:9][cH:10][n:11]2[cH:12][cH:13][s:14][c:15]12>CN(C)C=O.ClCCl.[NaH]>[CH3:1][CH:5]([NH:4][CH:3]=[O:2])[C:6](=[O:7])[c:8]1[n:9][cH:10][n:11]2[cH:12][cH:13][s:14][c:15]12|US20200102294A1_0232
1.2.9|[N&H2&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-O>>[N&H1&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|O[CH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[NH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>c1ccc(cc1)OP(Oc1ccccc1)Oc1ccccc1.O>[cH:12]1[cH:13][cH:14][c:9]([cH:10][cH:11]1)[NH:8][CH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1|US20090023753A1_0379
1.2.9|[C&H3&+0&D1:4]-O.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1]O.[CH3:2][CH2:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([n:11][c:12]1[C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[Cl:21]>CI.CN(C)C=O.[NaH]>[CH3:2][CH2:3][C:4](=[O:5])[N:6]([CH3:1])[c:7]1[cH:8][cH:9][c:10]([n:11][c:12]1[C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[Cl:21]|US08916599B2_0435
1.1.3|[C&H3&+0&D1:4]-I.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][c:12]1[cH:13][c:14]([c:15]([c:16]([cH:17]1)[C:18]([CH3:19])([CH3:20])[CH3:21])[OH:22])[C:23]([CH3:24])([CH3:25])[CH3:26].[CH3:27]I>CO.C[O-].O.[Na+]>[CH3:24][C:23]([CH3:25])([CH3:26])[c:14]1[cH:13][c:12]([cH:17][c:16]([c:15]1[OH:22])[C:18]([CH3:19])([CH3:20])[CH3:21])[N:11]([CH3:27])[S:8](=[O:9])(=[O:10])[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH3:1]|EP2953461B1_0122
7.6.1|[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[N:2])-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:3](-[N:2])-[c:1]|[CH2:1]=[C:2]1[c:3]2[nH:4][c:5]3[cH:6][cH:7][c:8]([cH:9][c:10]3[c:11]2[CH2:12][CH2:13][N:14]1[C:15](=[O:16])[CH:17]1[CH2:18][CH2:19]1)[O:20][CH3:21]>CC(=O)OCC.O=C(O)O[Na].[Pd]>[CH3:21][O:20][c:8]1[cH:7][cH:6][c:5]2[nH:4][c:3]3[c:11]([CH2:12][CH2:13][N:14]([CH:2]3[CH3:1])[C:15](=[O:16])[CH:17]3[CH2:18][CH2:19]3)[c:10]2[cH:9]1|US10294242B2_0368
1.7.7|[O&H1&+0&D1:4]-[c:3].[P:2]-[C&H2&+0&D2:1]-O>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[P:2]|[CH3:1][CH2:2][O:3][P:4](=[O:5])([CH2:6]O)[O:7][CH2:8][CH3:9].[NH2:10][c:11]1[n:12][c:13]2[c:14]([cH:15][nH:16][c:17]2[c:18]([nH:19]1)=[O:20])[CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][c:27]1[OH:28]>CN(C)C=O.O=C(O[Cs])O[Cs]>[CH3:1][CH2:2][O:3][P:4](=[O:5])([CH2:6][O:28][c:27]1[cH:26][cH:25][cH:24][cH:23][c:22]1[CH2:21][c:14]1[cH:15][nH:16][c:17]2[c:18]([nH:19][c:11]([n:12][c:13]12)[NH2:10])=[O:20])[O:7][CH2:8][CH3:9]|US06214877B1
1.2.9|[C&H3&+0&D1:4]-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&+0&D1:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1]O.[CH3:2][O:3][c:4]1[cH:5][cH:6][cH:7][nH:8][c:9]1=[O:10]>CI.O[K]>[CH3:2][O:3][c:4]1[cH:5][cH:6][cH:7][n:8]([c:9]1=[O:10])[CH3:1]|US20200199101A1_0228
7.3.3|[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[N&H2&+0&D1:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[NH:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][C:10]([F:11])([F:12])[F:13])[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[Br:20]>[Na+].CO.[BH4-]>[NH2:1][CH:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][C:10]([F:11])([F:12])[F:13])[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[Br:20]|EP0604800A1_0110
1.2.10|[C&H2&+0&D1:4]=O.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH2:1]=O.[NH2:2][c:3]1[n:4][c:5]([c:6]2[NH:7][CH:8]([CH2:9][NH:10][c:11]2[nH:12]1)[CH2:13][CH2:14][NH:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[C:22](=[O:23])[NH:24][C@@H:25]([CH2:26][CH2:27][C:28](=[O:29])[OH:30])[C:31](=[O:32])[OH:33])=[O:34]>[Na+].Nc1nc(c2nc(cnc2[nH]1)CCNc1ccc(cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)O)=O.[H][H].[BH4-]>[CH3:1][N:7]1[c:6]2[c:5]([n:4][c:3]([nH:12][c:11]2[NH:10][CH2:9][CH:8]1[CH2:13][CH2:14][NH:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[C:22](=[O:23])[NH:24][C@@H:25]([CH2:26][CH2:27][C:28](=[O:29])[OH:30])[C:31](=[O:32])[OH:33])[NH2:2])=[O:34]|EP2134723B1_0075
7.6.1|[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]|[CH2:1]=[C:2]1[CH2:3][CH:4]([CH2:5][CH2:6][C:7]2=[C:8]([CH2:9][CH2:10][CH:11]21)[CH3:12])[OH:13]>CCO.[H][H].[O-2].[Pt+2]>[CH3:12][C:8]1[CH2:9][CH2:10][CH:11]2[C:7]=1[CH2:6][CH2:5][CH:4]([CH2:3][CH:2]2[CH3:1])[OH:13]|US20200392150A1_0393
9.7.334|[c:4]:[n&H0&+0&D3:3](:[n&H0&+0&D2:2]:[c:1])-C>>[c:4]:[n&H0&+0&D2:3]:[n&H1&+0&D2:2]:[c:1]|[CH3:1][CH2:2][NH:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][n:9]2[cH:10][cH:11][c:12]([cH:13][c:14]2[n:15]1)-[c:16]1[n:17][c:18]([n:19]([n:20]1)C)[CH3:21]>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.OB(O)c1cncnc1.COCCOC.O=C(O[Na])O[Na].CC(=O)O.CCO.ClCCl.Cl[Pd]Cl.O.[Fe+2]>[CH3:1][CH2:2][NH:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][n:9]2[cH:10][cH:11][c:12]([cH:13][c:14]2[n:15]1)-[c:16]1[n:17][c:18]([n:19][nH:20]1)[CH3:21]|US07407971B2_0318
1.2.2|[N&H2&+0&D1:4]-[S:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:4](-[S:3])=[C&H1&+0&D2:1]-[c:2]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11].O=[CH:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[C:19](=[O:20])[OH:21]>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[O:20]=[C:19]([OH:21])[c:16]1[cH:17][cH:18][c:13]([cH:14][cH:15]1)[CH:12]=[N:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:10][cH:9][c:8]([cH:7][cH:6]1)[Cl:11]|EP3368544B1_0314
7.6.1|[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C:2])-[N:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:3](-[C:2])-[N:1]|[CH2:1]=[C:2]1[N:3]([c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[C:10]1([CH3:11])[CH3:12])[CH3:13]>O.[Na+].CCOCC.CO.[BH4-]>[CH3:13][N:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[C:10]([CH:2]1[CH3:1])([CH3:11])[CH3:12]|US07265237B2_0046
1.1.3|[C&H3&+0&D1:4]-I.[C:3]-[N&H1&+0&D2:2]-[N:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[N:1]|[CH3:1][N:2]([CH3:3])[NH:4][C:5](=[O:6])[NH:7][CH:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[O:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21.[CH3:22]I>CO.C1CCOC1.[NaH]>[CH3:22][N:4]([C:5](=[O:6])[NH:7][CH:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[O:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21)[N:2]([CH3:1])[CH3:3]|US20180354942A1_0314
7.5.1|[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C:4]-[C&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH:6]1[CH2:7][c:8]2[cH:9][cH:10][c:11]([cH:12][c:13]2[C:14]([CH2:15]1)=[O:16])[F:17]>[Na+].Cl.CO.[BH4-]>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH:6]1[CH2:7][c:8]2[cH:9][cH:10][c:11]([cH:12][c:13]2[CH:14]([CH2:15]1)[OH:16])[F:17]|US20040006081A1_0330
1.1.3|[C&H3&+0&D1:4]-I.[C:3]-[N&H1&+0&D2:2]-[S:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C:3])-[S:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]1[NH:6][S:7]([c:8]2[c:9]([cH:10][cH:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]32)[C:18]=1[OH:19])(=[O:20])=[O:21].[CH3:22]I>O.CO.O[Na]>[CH3:1][O:2][C:3](=[O:4])[C:5]1=[C:18]([c:9]2[cH:10][cH:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[c:8]2[S:7]([N:6]1[CH3:22])(=[O:20])=[O:21])[OH:19]|EP3174859B1_0173
9.5.4|[C:4]-[C&H2&+0&D2:3]-[C&H1&+0&D3:2](-[C:1])-O>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]|[O:1]=[C:2]([CH2:3][CH2:4][CH:5](O)[C:6]([Cl:7])([Cl:8])[Cl:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16]>Cc1ccc(cc1)S(=O)(=O)O.Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1.O>[O:1]=[C:2]([CH2:3][CH:4]=[CH:5][C:6]([Cl:7])([Cl:8])[Cl:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16]|US05153210A
1.8.15|[S&H1&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-I>>[S&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[CH2:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[CH2:18]I.[CH3:19][CH2:20][CH2:21][c:22]1[c:23]([c:24]([cH:25][cH:26][c:27]1[SH:28])[C:29]([CH3:30])=[O:31])[OH:32]>O.CCC(C)=O.O=C(O[Cs])O[Cs]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[CH2:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[CH2:18][S:28][c:27]1[cH:26][cH:25][c:24]([c:23]([c:22]1[CH2:21][CH2:20][CH3:19])[OH:32])[C:29]([CH3:30])=[O:31]|US20090018134A1_5461
1.1.3|[C&H3&+0&D1:4]-I.[N:3]-[N&H1&+0&D2:2]-[S:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[N:3])-[S:1]|[CH3:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([c:7]1[Cl:8])[Cl:9])[S:10]([NH:11][NH:12][CH:13]2[CH3:14])(=[O:15])=[O:16].[CH3:17]I>CC(C)(C)[O-].[K]>[CH3:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([c:7]1[Cl:8])[Cl:9])[S:10]([N:11]([NH:12][CH:13]2[CH3:14])[CH3:17])(=[O:15])=[O:16]|EP2483257B1_0124
1.6.4|[N&H2&+0&D1:4]-[N:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[N&H1&+0&D2:4](-[N:3])-[C&H2&+0&D2:1]-[c:2]|Cl.[CH3:1][C:2]([CH3:3])([CH3:4])[N:5]([NH2:6])[C:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.Cl[CH2:15][c:16]1[cH:17][cH:18][n:19][cH:20][cH:21]1>Cc1ccccc1.O[Na]>[CH3:1][C:2]([CH3:3])([CH3:4])[N:5]([NH:6][CH2:15][c:16]1[cH:21][cH:20][n:19][cH:18][cH:17]1)[C:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US20050124622A1_0113
3.8.2|[c:4]-[C&H2&+0&D2:3]-Br.[c:2]-[C&H1&+0&D2:1]=O>>[c:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:1]-[c:2]|O=[CH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[Br:8].Br[CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Br:16]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.Cc1ccccc1C.CC[O-].CCO.II.[Na+]>[Br:8][c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH:1]=[CH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Br:16]|US20160016860A1_0346
1.8.12|[S&H1&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[S&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[Cl:11])[SH:12])[C:13](=[O:14])[OH:15].Br[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O.Cl.O[Na]>[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[Cl:11])[S:12][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[C:13](=[O:14])[OH:15]|US06218431B1
3.8.2|[c:4]-[C&H2&+0&D2:3]-Cl.[c:2]-[C&H1&+0&D2:1]=O>>[c:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:1]-[c:2]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[CH:10]=O.Cl[CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>c1ccc(cc1)[PH+](c1ccccc1)c1ccccc1.CCO.[Na]>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[CH:10]=[CH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US10604466B1_0068
3.8.2|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[C&H1&+0&D2:1]=O>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C:9]([CH3:10])([CH3:11])[CH:12]=O.[CH3:13][C:14]1([CH2:15][CH2:16][C:17]([CH:18]1[CH2:19]Br)([CH3:20])[CH3:21])[CH3:22]>CCOCC.[Mg]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C:9]([CH3:10])([CH3:11])[CH:12]=[CH:19][CH:18]1[C:17]([CH2:16][CH2:15][C:14]1([CH3:13])[CH3:22])([CH3:20])[CH3:21]|US10863758B2_0082
9.7.64|[N&H4&+&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH4+:1].[CH3:2][c:3]1[cH:4][c:5]([n:6][n:7][c:8]1F)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[OH-]>>[CH3:2][c:3]1[cH:4][c:5]([n:6][n:7][c:8]1[NH2:1])-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US20200392128A1_0396
1.2.5|[N&H4&+&D0:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[N&H2&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[NH4+:1].[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]2[CH2:8][CH:9]3[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([C:15]3=O)([c:16]2[cH:17]1)[CH3:18].[OH-]>CCO.[H][H].[Ni]>[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]2[CH2:8][CH:9]3[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([c:16]2[cH:17]1)([CH:15]3[NH2:1])[CH3:18]|US20050239841A1_2052
1.2.5|[N&H4&+&D0:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H2&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[NH4+:1].CC([O-])=O.O=[C:2]1[CH2:3][CH2:4][c:5]2[cH:6][c:7]([c:8]([cH:9][c:10]12)[Cl:11])[Cl:12]>[Na+].N#C[BH3-]>[NH2:1][CH:2]1[CH2:3][CH2:4][c:5]2[cH:6][c:7]([c:8]([cH:9][c:10]21)[Cl:11])[Cl:12]|US09981970B2_0256
1.7.9|[O&H1&+0&D1:4]-[c:3].[n:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[n:2]|[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.Cl[CH2:15][n:16]1[cH:17][n:18][c:19]([c:20]1[Cl:21])[Cl:22]>O.CN(C)C=O.[H][H].[NaH]>[Cl:22][c:19]1[n:18][cH:17][n:16]([c:20]1[Cl:21])[CH2:15][O:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US20200181122A1_0357
1.6.4|[N&H2&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[N&H1&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][c:12]1[c:13]([cH:14][c:15]([cH:16][c:17]1[S:18]([NH2:19])(=[O:20])=[O:21])[C:22](=[O:23])[OH:24])[NH2:25].Cl[CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>O.O[Na]>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][c:12]1[c:13]([cH:14][c:15]([cH:16][c:17]1[S:18]([NH2:19])(=[O:20])=[O:21])[C:22](=[O:23])[OH:24])[NH:25][CH2:26][c:27]1[cH:32][cH:31][cH:30][cH:29][cH:28]1|EP0799864A1_0042
3.11.91|[C&H3&+0&D1:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H2&+0&D2:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][C:6]([CH3:7])=[O:8].[CH3:9][C:10]#[C:11][CH2:12]Br>CCCC[Li].[NaH]>[CH3:9][C:10]#[C:11][CH2:12][CH2:7][C:6](=[O:8])[CH2:5][C:3](=[O:4])[O:2][CH3:1]|EP2483278B1_0252
9.7.253|[C:4]-[C&H1&+0&D3:3](-[C&H2&+0&D2:2]-[c:1])-Br>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][c:2]1[o:3][c:4]([n:5][c:6]1[CH2:7][CH2:8][O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][CH:17](Br)[C:18](=[O:19])[O:20][CH3:21])-[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>CCOC(C)=O.Cc1ccccc1.C1CN=C2CCCCCN2C1>[CH3:21][O:20][C:18](=[O:19])[CH:17]=[CH:16][c:13]1[cH:14][cH:15][c:10]([cH:11][cH:12]1)[O:9][CH2:8][CH2:7][c:6]1[n:5][c:4]([o:3][c:2]1[CH3:1])-[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|US07009047B2_0050
3.3.2|[C&H1&+0&D1:4]#[C:3].[C:2]=[C&H1&+0&D2:1]-Br>>[C&H0&+0&D2:4](#[C:3])-[C&H1&+0&D2:1]=[C:2]|Br/[CH:1]=[CH:2]/[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[CH:9]#[C:10][CH2:11][CH2:12][CH2:13][OH:14]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCNCC.Cl[Pd]Cl.I[Cu]>[OH:14][CH2:13][CH2:12][CH2:11][C:10]#[C:9]/[CH:1]=[CH:2]/[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|US20200347078A1_0755
1.7.9|[O&H1&+0&D1:4]-[c:3].[O:2]-[C&H2&+0&D2:1]-Br>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[O:2]|[CH3:1][CH2:2][CH2:3][O:4][CH2:5]Br.[O-:6][N+:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[OH:15]>CC(C)=O.O=C(O[K])O[K]>[CH3:1][CH2:2][CH2:3][O:4][CH2:5][O:15][c:14]1[cH:13][cH:12][cH:11][cH:10][c:9]1[N+:7]([O-:6])=[O:8]|EP3240424B1_0116
4.1.66|[S:4]-[N&H1&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-O>>[S:4]-[N&H0&+0&D3:3]1-[C&H2&+0&D2:1]-[C:2]-1|[CH3:1][C:2]#[C:3][CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:12](=[O:13])(=[O:14])[NH:15][CH:16]([CH2:17]O)[C:18](=[O:19])[O:20][CH3:21]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)N=NC(=O)OCC.C1CCOC1>[CH3:1][C:2]#[C:3][CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:12](=[O:13])(=[O:14])[N:15]1[CH2:17][CH:16]1[C:18](=[O:19])[O:20][CH3:21]|US09566265B2_0328
3.11.91|[C&H3&+0&D1:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H2&+0&D2:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[Br:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[CH2:9]Br.[CH3:10][C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17]>CN(C)P(=O)(N(C)C)N(C)C.CC(C)NC(C)C.CCCC[Li].C1CCOC1.O.O>[CH3:15][C:14]([CH3:16])([CH3:17])[O:13][C:11](=[O:12])[CH2:10][CH2:9][c:7]1[cH:6][cH:5][cH:4][c:3]([cH:8]1)[CH2:2][Br:1]|US20150266834A1_0616
9.7.253|[C:4]-[C&H2&+0&D2:3]-[C&H1&+0&D3:2](-[c:1])-Br>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][CH:6]([CH2:7][CH:8](Br)[c:9]1[cH:10][n:11][cH:12][cH:13][n:14]1)[O:15][C:16]([CH3:17])=[O:18]>Cc1ccccc1.C1CN=C2CCCCCN2C1>[CH3:1][C:2](=[O:3])[O:4][CH2:5][CH:6]([CH:7]=[CH:8][c:9]1[cH:10][n:11][cH:12][cH:13][n:14]1)[O:15][C:16]([CH3:17])=[O:18]|US20170088546A1_0385
4.1.66|[C:4]-[N&H1&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-O>>[C:4]-[N&H0&+0&D3:3]1-[C&H2&+0&D2:1]-[C:2]-1|[O:1]=[C:2]([CH2:3][C:4]([OH:5])([CH2:6][n:7]1[cH:8][n:9][cH:10][n:11]1)[c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[Cl:18])[Cl:19])[NH:20][CH2:21][CH2:22]O>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)N=NC(=O)OCC.C1CCOC1.O>[O:1]=[C:2]([CH2:3][C:4]([OH:5])([CH2:6][n:7]1[cH:8][n:9][cH:10][n:11]1)[c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[Cl:18])[Cl:19])[N:20]1[CH2:21][CH2:22]1|US10137124B2_2067
3.9.18|[C&H1&+0&D1:4]#[C:3].[C:2]#[C&H0&+0&D2:1]-Br>>[C&H0&+0&D2:4](#[C:3])-[C&H0&+0&D2:1]#[C:2]|[CH:1]#[C:2][CH2:3][n:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21.[CH3:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]#[C:30]Br>O.Cl.Cl.CCN.CN(C)C=O.NO.Cl[Na].Cl[Cu].Br[K]>[CH3:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]#[C:30][C:1]#[C:2][CH2:3][n:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21|US20200392096A1_0383
9.7.64|[N&H4&+&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH4+:1].[O-:2][N+:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[F:11])F.[OH-]>>[NH2:1][c:8]1[cH:7][cH:6][c:5]([cH:10][c:9]1[F:11])[N+:3]([O-:2])=[O:4]|US20200087318A1_0388
9.7.10|[I&H0&-&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-N>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[I-:1].[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)N>>[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[I:1]|US07314849B2_0146
9.5.4|[C:4]-[C@&H1&+0&D3:3](-[C&H2&+0&D2:2]-[C:1])-O>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]|[CH3:1][CH2:2][C@:3]12[CH2:4][CH2:5][C@@H:6]3[C@H:7]4[CH2:8][CH2:9][CH2:10][CH:11]=[C:12]4[CH2:13][CH2:14][C@H:15]3[C@@H:16]1[C@H:17]([CH2:18][C:19]2=[O:20])O>O.O.[Na+].CC([O-])=O.CN(C)C=O.CS(=O)(=O)Cl.c1ccncc1>[CH3:1][CH2:2][C@:3]12[CH2:4][CH2:5][C@@H:6]3[C@H:7]4[CH2:8][CH2:9][CH2:10][CH:11]=[C:12]4[CH2:13][CH2:14][C@H:15]3[C@@H:16]1[CH:17]=[CH:18][C:19]2=[O:20]|US09012667B2_0168
1.7.9|[O&H1&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH:2]([O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10]Br)[C:11](=[O:12])[OH:13].[OH:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CCO.CCOC(=O)C(C)Br.CC(Oc1ccc(cc1)CO)C(=O)O.OCc1ccc(cc1)O.[Na]>[CH3:1][CH:2]([O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10][O:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1)[C:11](=[O:12])[OH:13]|US07932390B2_0203
1.8.13|[S&H1&+0&D1:4]-[c:3].[S:2]-[C&H2&+0&D2:1]-Cl>>[S&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[S:2]|[CH3:1][c:2]1[o:3][cH:4][cH:5][c:6]1[SH:7].[CH3:8][S:9][CH2:10]Cl>[Na+].C[O-].CO>[CH3:8][S:9][CH2:10][S:7][c:6]1[cH:5][cH:4][o:3][c:2]1[CH3:1]|US06635771B2
5.3.1|[O&H1&+0&D1:4]-[n:3].[c:2]-[C&H2&+0&D2:1]-Br>>[O&H0&+0&D2:4](-[n:3])-[C&H2&+0&D2:1]-[c:2]|[OH:1][n:2]1[c:3]2[cH:4][c:5]([cH:6][n:7][c:8]2[n:9][c:10]1[C:11]([F:12])([F:13])[F:14])[Cl:15].Br[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O=C(O[K])O[K].CCO>[F:12][C:11]([F:13])([F:14])[c:10]1[n:9][c:8]2[n:7][cH:6][c:5]([cH:4][c:3]2[n:2]1[O:1][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[Cl:15]|US08912330B2_0406
1.6.2|[N&H2&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[N&H1&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[NH2:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[S:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[S:15]([NH2:16])(=[O:17])=[O:18])[C:19](=[O:20])[OH:21].Br[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>O.Cl.O[Li]>[NH2:16][S:15](=[O:17])(=[O:18])[c:6]1[cH:5][c:4]([cH:3][c:2]([c:7]1[S:8][c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1)[NH:1][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:19](=[O:20])[OH:21]|US09090573B2_1625
1.6.2|[C&H3&+0&D1:4]-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&+0&D1:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1]Br.[O:2]=[c:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[n:10][c:11]2[nH:12][c:13]3[cH:14][c:15]([c:16]([cH:17][c:18]3[n:19]12)[Cl:20])[Cl:21]>>[CH3:1][n:12]1[c:13]2[cH:14][c:15]([c:16]([cH:17][c:18]2[n:19]2[c:3]([c:4]3[cH:5][cH:6][cH:7][cH:8][c:9]3[n:10][c:11]12)=[O:2])[Cl:20])[Cl:21]|US20130274258A1_0310
1.7.9|[O&H1&+0&D1:4]-[c:3].[S:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[S:2]|[Na+:1].[O-:2][S:3](=[O:4])(=[O:5])[CH2:6]Cl.[OH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20]>O.O[Na]>[Na+:1].[O-:2][S:3](=[O:4])(=[O:5])[CH2:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20]|US20200377460A1_0591
3.8.2|[C:4]-[C&H2&+0&D2:3]-Br.[c:2]-[C&H1&+0&D2:1]=O>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:1]-[c:2]|O=[CH:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[Br:8].[CH3:9][CH2:10][CH2:11][CH2:12][CH2:13]Br>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCCCCC.CCCC[Li].C1CCOC1>[CH3:9][CH2:10][CH2:11][CH2:12][CH:13]=[CH:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[Br:8]|US20200323859A1_0439
3.11.91|[C&H3&+0&D1:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H2&+0&D2:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])[CH:4]=[C:5]([CH3:6])[CH3:7].[CH3:8][C:9]([CH3:10])=[CH:11][CH2:12]Cl>CCNCC.O[Na]>[CH3:8][C:9]([CH3:10])=[CH:11][CH2:12][CH2:1][C:2](=[O:3])[CH:4]=[C:5]([CH3:6])[CH3:7]|EP1186305A1_0061
5.3.6|[O&H1&+0&D1:4]-[c:3].[O:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[O:2]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH3:6])[c:7]1[cH:8][cH:9][c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[cH:16]1)[OH:17].[CH3:18][O:19][CH2:20]Cl>CN(C)C=O>[CH3:18][O:19][CH2:20][O:17][c:12]1[cH:13][cH:14][c:15]2[cH:16][c:7]([cH:8][cH:9][c:10]2[cH:11]1)[CH:5]([CH3:6])[C:3](=[O:4])[O:2][CH3:1]|US06251926B1
1.8.13|[S&H1&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[S&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[Cl-:1].[NH2:2][c:3]1[cH:4][n:5][n+:6]([c:7]([cH:8]1)[SH:9])-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.Cl[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>Cc1ccccc1>[Cl-:1].[NH2:2][c:3]1[cH:4][n:5][n+:6]([c:7]([cH:8]1)[S:9][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)-[c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US05700943A
9.7.253|[C:4]-[C&H1&+0&D3:3](-[C&H2&+0&D2:2]-[C:1])-Br>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]|[CH3:1][O:2][C:3]1([C@@H:4]2[O:5][c:6]3[c:7]([cH:8][cH:9][c:10]4[CH2:11][C@@H:12]5[C@H:13]([CH2:14][CH:15]1Br)[C@@:16]2([CH2:17][CH2:18][N:19]5[CH3:20])[c:21]34)[O:22][CH3:23])[O:24][CH3:25]>O.CS(C)=O.O[K]>[CH3:23][O:22][c:7]1[cH:8][cH:9][c:10]2[CH2:11][C@@H:12]3[C@@H:13]4[CH:14]=[CH:15][C:3]([C@@H:4]5[O:5][c:6]1[c:21]2[C@:16]45[CH2:17][CH2:18][N:19]3[CH3:20])([O:24][CH3:25])[O:2][CH3:1]|US20180057470A1_0519
9.7.73|[N&+:4]=[N&H0&-&D1:3].[c:2]-[C&H2&+0&D2:1]-O>>[N&+:4]=[N&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9]O.[N-:10]=[N+:11]=[N-:12].[Na+]>CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)CC.CCOC(C)=O.CCOCC.CS(=O)(=O)Cl.ClCCl.[Cl-]>[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][N:10]=[N+:11]=[N-:12]|US20050154042A1_0785
1.7.9|[O&H1&+0&D1:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH2:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[OH:15].Cl[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>CN(C)C=O.[NaH]>[OH:15][c:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[CH2:8][c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[O:1][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US09096500B2_0567
9.7.59|[C:4]-[C&H0&+0&D4:3](-[C:2])(-[Cl&H0&D1:1])-Cl>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[Cl&H0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH:7]([O:8][CH:9]2[N:10]1[C:11]([C:12]2([Cl:13])Cl)=[O:14])[CH2:15][CH3:16]>O.[Na+].CCO.[O-]C(=O)O.[Pd]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH:7]([O:8][CH:9]2[CH:12]([C:11]([N:10]12)=[O:14])[Cl:13])[CH2:15][CH3:16]|US04079148A
9.7.73|[C:4]-[C&H2&+0&D2:3]-O.[N&+:2]=[N&H0&-&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]1([CH2:10][CH2:11][CH2:12][CH2:13][N:14]([C:15]1=[O:16])[CH2:17][CH2:18]O)[CH2:19][CH3:20].[N-:21]=[N+:22]=[N-:23].[Na+]>CCN(CC)CC.CN(C)C=O.CS(=O)(=O)Cl.ClCCl>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]1([CH2:10][CH2:11][CH2:12][CH2:13][N:14]([C:15]1=[O:16])[CH2:17][CH2:18][N:21]=[N+:22]=[N-:23])[CH2:19][CH3:20]|EP3050888A1_0190
3.3.3|[C&H1&+0&D1:4]#[C:3].[C:2]=[C&H1&+0&D2:1]-Cl>>[C&H0&+0&D2:4](#[C:3])-[C&H1&+0&D2:1]=[C:2]|[CH3:1][CH2:2][O:3][CH:4]([C:5]#[C:6]/[CH:7]=[CH:8]\Cl)[O:9][CH2:10][CH3:11].[CH:12]#[C:13][Si:14]([CH3:15])([CH3:16])[CH3:17]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.C#CC(OCC)OCC.CCCCN.Cl/C=C\Cl.[I-].[I-].[Cu+2].[Pd]>[CH3:1][CH2:2][O:3][CH:4]([C:5]#[C:6]/[CH:7]=[CH:8]\[C:12]#[C:13][Si:14]([CH3:15])([CH3:16])[CH3:17])[O:9][CH2:10][CH3:11]|US20060004230A1_0020
9.7.80|[N&H3&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH3:1].CO.[F:2][C:3]([F:4])([F:5])[c:6]1[cH:7][n:8][c:9]([cH:10][c:11]1I)[Cl:12]>>[NH2:1][c:11]1[cH:10][c:9]([n:8][cH:7][c:6]1[C:3]([F:2])([F:4])[F:5])[Cl:12]|US20190233420A1_1565
9.7.23|[N&+:4]=[N&H0&-&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[N&+:4]=[N&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[Na+].[N-:1]=[N+:2]=[N-:3].[O:4]=[C:5]([OH:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH2:13]Br>O.CC(C)=O>[N-:1]=[N+:2]=[N:3][CH2:13][c:10]1[cH:11][cH:12][c:7]([cH:8][cH:9]1)[C:5](=[O:4])[OH:6]|US20200131144A1_0278
9.5.4|[C:4]-[C&H1&+0&D3:3](-[N:2])-[C&H2&+0&D2:1]-O>>[C:4]-[C&H0&+0&D3:3](-[N:2])=[C&H2&+0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[S:9](=[O:10])(=[O:11])[N:12]([CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[NH:20][C:21](=[O:22])[C:23]([F:24])([F:25])[F:26])[CH:27]([CH2:28]O)[C:29](=[O:30])[O:31][CH3:32]>O=C(OC(=O)C(F)(F)F)C(F)(F)F.ClCCl>[CH2:28]=[C:27]([C:29](=[O:30])[O:31][CH3:32])[N:12]([CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[NH:20][C:21](=[O:22])[C:23]([F:24])([F:25])[F:26])[S:9](=[O:10])(=[O:11])[c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[O:2][CH3:1]|US04407815A
9.7.334|[C:3]-[N&H0&+0&D3:2](-[C:1])-[C@@&H1](-C)-c1:c:c:c(-O-C):c:c:1>>[C:3]-[N&H1&+0&D2:2]-[C:1]|COc1ccc(cc1)[C@H](C)[N:1]1[CH2:2][C@@H:3]([CH2:4][C:5]1=[O:6])[C@@H:7]([CH3:8])[O:9][c:10]1[cH:11][c:12]([cH:13][c:14]2[n:15][cH:16][cH:17][cH:18][c:19]21)-[c:20]1[cH:21][cH:22][cH:23][cH:24][n:25]1>>[CH3:8][C@@H:7]([O:9][c:10]1[cH:11][c:12]([cH:13][c:14]2[n:15][cH:16][cH:17][cH:18][c:19]12)-[c:20]1[cH:21][cH:22][cH:23][cH:24][n:25]1)[C@@H:3]1[CH2:4][C:5]([NH:1][CH2:2]1)=[O:6]|US20200239439A1_0359
9.7.39|[N&H4&+&D0:4].[C:3]-[C&H0&+0&D3:2](=[C:1])-Cl>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](-[C:3])=[C:1]|[NH4+:1].[CH3:2][CH:3]([CH3:4])[C:5](Cl)=[C:6]([C:7]#[N:8])[C:9]#[N:10].[OH-]>O.CCO>[CH3:2][CH:3]([CH3:4])[C:5]([NH2:1])=[C:6]([C:7]#[N:8])[C:9]#[N:10]|US20140336187A1_0128
9.7.255|[C:4]-[C&H1&+0&D3:3](-[O:2])-[C&H2&+0&D2:1]-I>>[C:4]-[C&H0&+0&D3:3](-[O:2])=[C&H2&+0&D1:1]|[O:1]=[c:2]1[c:3]2[cH:4][cH:5][cH:6][n:7][c:8]2[n:9]([c:10]2[O:11][CH:12]([CH2:13][c:14]12)[CH2:15]I)-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>C1CCNCC1>[CH2:15]=[C:12]1[CH2:13][c:14]2[c:10]([O:11]1)[n:9]([c:8]1[n:7][cH:6][cH:5][cH:4][c:3]1[c:2]2=[O:1])-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US09708357B2_0248
9.7.23|[C:4]-[C&H2&+0&D2:3]-Br.[N&+:2]=[N&H0&-&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:7])[N:8]([CH2:9][CH2:10]Br)[N:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.CN(C)C(N)=[N+](C)C.[N-:19]=[N+:20]=[N-:21]>C1COCCOCCOCCOCCOCCO1.CC(C)=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:7])[N:8]([CH2:9][CH2:10][N:21]=[N+:20]=[N-:19])[N:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US20190015387A1_1061
9.7.42|[F&H0&-&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[F&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[F:1][c:2]1[cH:3][c:4]([cH:5][n:6][c:7]1Cl)[Cl:8].[F-:9].[Cs]>O.O.O=S1(CCCC1)=O.F[K]>[F:1][c:2]1[cH:3][c:4]([cH:5][n:6][c:7]1[F:9])[Cl:8]|US20200255451A1_2022
9.7.40|[C:4]-[C&H2&+0&D2:3]-Cl.[N&+:2]=[N&H0&-&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][C:2]1([NH:3][C:4]([NH:5][C:6]1=[O:7])=[O:8])[CH2:9][CH2:10][CH2:11]Cl.[N-:12]=[N+:13]=[N-:14]>O.CN(C)C=O.[N-]=[N+]=N[Na]>[CH3:1][C:2]1([NH:3][C:4]([NH:5][C:6]1=[O:7])=[O:8])[CH2:9][CH2:10][CH2:11][N:14]=[N+:13]=[N-:12]|EP3279197A1_0141
9.7.73|[C:4]-[C&H2&+0&D2:3]-O.[N&+:2]=[N&H1&+0&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][CH2:2][C:3]([CH3:4])([CH2:5]O)[NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[N-:17]=[N+:18]=[NH:19]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CC(C)OC(=O)N=NC(=O)OC(C)C.CCCCCC.CCOC(C)=O.O=S1(O[Mg]O1)=O.[N-]=[N+]=[N-].ClCCl>[CH3:1][CH2:2][C:3]([CH3:4])([CH2:5][N:19]=[N+:18]=[N-:17])[NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|EP0105658A1_0131
9.7.173|[O&H2&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-N>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[OH2:1].N[c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH:8]1[CH2:9][C:10]1([Cl:11])[Cl:12]>CC(=O)O.O=NO[Na].O=S(=O)(O)O>[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH:8]1[CH2:9][C:10]1([Cl:11])[Cl:12]|EP3339303B1_0626
2.6.2|[#14:4]-[C&H2&+0&D2:3]-Cl.[C:2]-[O&H0&-&D1:1]>>[#14:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Si:10]([CH3:11])([CH3:12])[CH2:13]Cl.[CH3:14][C:15]([O-:16])=[O:17].[Na+]>CCCC[N+](CCCC)(CCCC)CCCC.CCOCC.ClC(Cl)(Cl)Cl.[Cl-]>[CH3:14][C:15](=[O:17])[O:16][CH2:13][Si:10]([CH3:11])([CH3:12])[c:7]1[cH:6][cH:5][c:4]([cH:9][cH:8]1)[O:3][CH2:2][CH3:1]|EP0291787A1_0067
9.7.40|[N&+:4]=[N&H0&-&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[N&+:4]=[N&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[Na+].[CH3:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[CH2:8]Cl)[N+:9]([O-:10])=[O:11].[N-:12]=[N+:13]=[N-:14]>O.CCO>[CH3:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[CH2:8][N:14]=[N+:13]=[N-:12])[N+:9]([O-:10])=[O:11]|US20190284182A1_1810
1.6.4|[S:4]-[N&H1&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-Cl>>[S:4]-[N&H0&+0&D3:3]1-[C&H2&+0&D2:1]-[C:2]-1|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][CH2:12][CH2:13]Cl>>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[N:11]1[CH2:12][CH2:13]1|EP3444237B1_0232
3.11.17|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH:2]([CH3:3])[CH2:4][CH2:5][CH2:6]Br.[CH2:7]=[CH:8][CH2:9]Br>Cl[Cu-2](Cl)(Cl)Cl.C1CCOC1.[NH4+].O.[Cl-].[Li+].[Li+].[Mg]>[CH2:7]=[CH:8][CH2:9][CH2:6][CH2:5][CH2:4][CH:2]([CH3:1])[CH3:3]|US20100048453A1_0125
9.7.66|[O&H2&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[OH2:1].[CH3:2][CH:3]([C:4](=[O:5])[OH:6])[c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)F)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>OCCO.O[K]>[CH3:2][CH:3]([C:4](=[O:5])[OH:6])[c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[OH:1])-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US20200039945A1_0893
9.7.39|[N&H4&+&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH4+:1].[OH:2][n:3]1[c:4]2[c:5]([cH:6][cH:7][n:8][c:9]2[n:10][c:11]1[C:12]([F:13])([F:14])[Cl:15])Cl.[OH-]>>[NH2:1][c:5]1[cH:6][cH:7][n:8][c:9]2[n:10][c:11]([n:3]([c:4]21)[OH:2])[C:12]([F:13])([F:14])[Cl:15]|US20140151548A1_0156
1.7.9|[O&H1&+0&D1:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:4]1-[C&H2&+0&D2:1]-[C:2]-[C:3]-1|[OH:1][CH2:2][C:3]([CH2:4][Cl:5])([CH2:6][Cl:7])[CH2:8]Cl>CCO.O[K]>[Cl:7][CH2:6][C:3]1([CH2:8][O:1][CH2:2]1)[CH2:4][Cl:5]|US20200024273A1_0694
9.7.66|[O&H2&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[OH2:1].[OH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[S:9][c:10]1[cH:11][cH:12][cH:13][c:14]([n:15]1)F>Cl.O[Na].ClCCl>[OH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[S:9][c:10]1[cH:11][cH:12][cH:13][c:14]([n:15]1)[OH:1]|EP3515903B1_0313
9.7.291|[N&H3&+0&D0:4].[N:3]-[C&H0&+0&D3:2](-[N:1])=S>>[N&H1&+0&D1:4]=[C&H0&+0&D3:2](-[N:3])-[N:1]|[NH3:1].S=[C:2]([NH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10])[NH:11][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1>CCO.O=[Hg].S=[Hg]>[NH:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10])[NH:11][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1|EP3431474A1_0280
9.7.83|[O&H2&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[OH2:1].[O:2]=[C:3]([OH:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([cH:10]1)I)[Br:11]>[Na+].O([Cu])[Cu].[OH-]>[O:2]=[C:3]([OH:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([cH:10]1)[OH:1])[Br:11]|US20200306256A1_0494
9.7.39|[N&H4&+&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH4+:1].[CH3:2][O:3][c:4]1[cH:5][n+:6]([cH:7][c:8]([n:9]1)Cl)[O-:10].[OH-]>>[CH3:2][O:3][c:4]1[cH:5][n+:6]([cH:7][c:8]([n:9]1)[NH2:1])[O-:10]|EP3221317B1_0880
9.7.22|[N&H4&+&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH4+:1].[O:2]=[S:3]1[c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2-[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)Br.[OH-]>Br[Cu]>[NH2:1][c:7]1[cH:6][cH:5][c:4]2[c:9]([cH:8]1)-[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[S:3]2=[O:2]|EP2964644B1_0177
9.7.64|[N&H3&+0&D0:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-F>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[NH3:1].[F:2][c:3]1[cH:4][c:5]([n:6][c:7]([n:8]1)F)[F:9]>CCO>[NH2:1][c:7]1[n:8][c:3]([cH:4][c:5]([n:6]1)[F:9])[F:2]|US20150225404A1_1197
9.7.173|[O&H2&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-N>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[OH2:1].[CH3:2][O:3][c:4]1[n:5][c:6]([cH:7][n:8][c:9]1N)[O:10][CH3:11]>NC(N)=O.O=NO[Na].O=S(=O)(O)O>[CH3:2][O:3][c:4]1[n:5][c:6]([cH:7][n:8][c:9]1[OH:1])[O:10][CH3:11]|US04994464A
9.7.22|[N&H4&+&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH4+:1].[OH:2][c:3]1[n:4][cH:5][c:6]([n:7][c:8]1[N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1)Br.[OH-]>>[NH2:1][c:6]1[cH:5][n:4][c:3]([c:8]([n:7]1)[N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1)[OH:2]|EP3741752A1_0574
9.7.173|[O&H2&+0&D0:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-N>>[O&H1&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[OH2:1].N[CH:2]([CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[N+:10]([O-:11])=[O:12])[C:13](=[O:14])[OH:15]>Cl.O=NO[Na].O=S(=O)(O)O>[O-:11][N+:10](=[O:12])[c:7]1[cH:8][cH:9][c:4]([cH:5][cH:6]1)[CH2:3][CH:2]([OH:1])[C:13](=[O:14])[OH:15]|US20110130365A1_0132
9.7.39|[N&H4&+&D0:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Cl:1][c:2]1[n:3][c:4]([n:5][c:6]([n:7]1)[Cl:8])Cl.[NH4+:9].[OH-]>O>[NH2:9][c:4]1[n:5][c:6]([n:7][c:2]([n:3]1)[Cl:1])[Cl:8]|US20190292188A1_0920
1.2.5|[N&H3&+0&D0:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[N&H2&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[NH3:1].O=[C:2]1[CH:3]2[CH:4]3[c:5]4[cH:6][cH:7][cH:8][cH:9][c:10]4[CH:11]1[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[CH:18]32>[Na+].CO.[BH4-]>[NH2:1][CH:2]1[CH:11]2[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[CH:18]3[CH:4]([c:5]4[cH:6][cH:7][cH:8][cH:9][c:10]42)[CH:3]31|US20110183382A1_0296
1.7.9|[#50:4]-[C&H2&+0&D2:3]-I.[C:2]-[O&H1&+0&D1:1]>>[#50:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[CH2:14]I.[OH:15][CH2:16][CH2:17][CH2:18][c:19]1[cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[cH:28]1>CCCCCC.C1CCOC1.[KH]>[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[CH2:14][O:15][CH2:16][CH2:17][CH2:18][c:19]1[cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[cH:28]1|US07932272B2_0484
1.2.5|[N&H3&+0&D0:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H2&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[NH3:1].[CH3:2][C:3]1([CH2:4][c:5]2[s:6][cH:7][cH:8][c:9]2[C:10]1=O)[CH3:11]>C1CCOC1.[H][H].[Pt]>[CH3:2][C:3]1([CH2:4][c:5]2[s:6][cH:7][cH:8][c:9]2[CH:10]1[NH2:1])[CH3:11]|EP3660016A1_0615
9.7.173|[O&H2&+0&D0:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-N>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[OH2:1].N[c:2]1[n:3][cH:4][c:5]2[CH2:6][N:7]=[C:8]([c:9]3[cH:10][c:11]([cH:12][cH:13][c:14]3-[c:15]2[n:16]1)[Cl:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[F:24]>[NH4+].O=S(=O)(O)O.[OH-]>[OH:1][c:2]1[n:3][cH:4][c:5]2[CH2:6][N:7]=[C:8]([c:9]3[cH:10][c:11]([cH:12][cH:13][c:14]3-[c:15]2[n:16]1)[Cl:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[F:24]|US20200323852A1_0236
9.5.4|[C:4]-[C&H1&+0&D3:3](-[C:2])-[C&H2&+0&D2:1]-O>>[C:4]-[C&H0&+0&D3:3](-[C:2])=[C&H2&+0&D1:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][CH:5]([CH2:6]O)[C:7](=[O:8])[OH:9]>O=P(O)O>[CH2:6]=[C:5]([CH2:4][CH:2]([CH3:1])[CH3:3])[C:7](=[O:8])[OH:9]|US09670192B2_1184
9.7.64|[N&H3&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH3:1].[CH3:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[S:11]([NH2:12])(=[O:13])=[O:14])F>CCO>[CH3:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[S:11]([NH2:12])(=[O:13])=[O:14])[NH2:1]|US20200039961A1_0470
3.11.91|[C:4]-[C&H2&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[C&H1&+0&D3:3]1-[C&H2&+0&D2:1]-[C:2]-1|[O:1]=[C:2]([CH2:3][CH2:4][CH2:5]Cl)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[F:12]>O.[OH-].[K+]>[O:1]=[C:2]([c:6]1[cH:11][cH:10][c:9]([cH:8][cH:7]1)[F:12])[CH:3]1[CH2:4][CH2:5]1|US06147216A
9.7.64|[N&H3&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH3:1].[CH3:2][CH2:3][CH2:4][CH2:5][O:6][C:7](=[O:8])[c:9]1[cH:10][cH:11][c:12]([n:13][c:14]1F)[F:15]>O.NC=O>[CH3:2][CH2:3][CH2:4][CH2:5][O:6][C:7](=[O:8])[c:9]1[cH:10][cH:11][c:12]([n:13][c:14]1[NH2:1])[F:15]|US20200247815A1_0536
9.7.39|[N&H3&+0&D0:4].[C:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](=[C:3])-[c:1]|[NH3:1].[CH3:2][CH2:3][NH:4][C:5](=[O:6])[C:7](/[C:8]#[N:9])=[C:10](\Cl)[c:11]1[cH:12][c:13]([c:14]([c:15]([cH:16]1)[N+:17]([O-:18])=[O:19])[O:20][CH3:21])[O:22][CH3:23]>CC#N.ClCCl>[CH3:23][O:22][c:13]1[cH:12][c:11]([cH:16][c:15]([c:14]1[O:20][CH3:21])[N+:17]([O-:18])=[O:19])[C:10](/[NH2:1])=[C:7](\[C:8]#[N:9])[C:5](=[O:6])[NH:4][CH2:3][CH3:2]|EP3386591B1_0413
9.7.22|[N&H3&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH3:1].[NH2:2][c:3]1[c:4]([cH:5][c:6]([c:7]2[C:8]([c:9]3[cH:10][cH:11][cH:12][cH:13][c:14]3[C:15]([c:16]12)=[O:17])=[O:18])Br)[S:19](=[O:20])(=[O:21])[OH:22]>O>[NH2:1][c:6]1[cH:5][c:4]([c:3]([c:16]2[C:15]([c:14]3[cH:13][cH:12][cH:11][cH:10][c:9]3[C:8]([c:7]12)=[O:18])=[O:17])[NH2:2])[S:19](=[O:20])(=[O:21])[OH:22]|EP3431474A1_0239
10.1.1|[Br&H0&+0&D1:4]-Br.[C:3]-[C&H2&+0&D2:2]-[O:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[O:1]|[F:1][CH:2]([F:3])[C:4]([F:5])([F:6])[O:7][CH2:8][C:9]([F:10])([F:11])[F:12].[Br:13]Br>O=C=O>[F:1][CH:2]([F:3])[C:4]([F:5])([F:6])[O:7][CH:8]([Br:13])[C:9]([F:10])([F:11])[F:12]|US08486996B2_0611
9.7.27|[O&H2&+0&D0:4].[C:3]-[C&H1&+0&D3:2](-[c:1])-Br>>[O&H1&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[OH2:1].Br.[O:2]=[C:3]([c:4]1[cH:5][cH:6][cH:7][n:8][cH:9]1)[CH:10](Br)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>CC(=O)OC(C)=O.CC([O-])=O.[K+]>[O:2]=[C:3]([c:4]1[cH:9][n:8][cH:7][cH:6][cH:5]1)[CH:10]([OH:1])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US10098878B2_0439
10.1.1|[Br&H0&+0&D1:4]-Br.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Br:1]Br.[CH:2]1=[CH:3][n:4]2[cH:5][n:6][n:7][c:8]2[CH2:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]12>ClC(Cl)Cl.c1ccncc1>[Br:1][c:5]1[n:6][n:7][c:8]2[CH2:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH:2]=[CH:3][n:4]12|EP2891717B1_0337
10.1.1|[Br&H0&+0&D1:4]-Br.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][s:8][c:9]([nH:10]1)=[O:11].[Br:12]Br>ClC(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[nH:10][c:9]([s:8][c:7]1[Br:12])=[O:11]|US20190375743A1_0897
9.7.27|[O&H2&+0&D0:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-Br>>[O&H1&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[OH2:1].[O:2]=[C:3]([OH:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1=[CH:12][CH:13]([CH2:14][C:15]1=[O:16])Br>CC(C)=O.F[B-](F)(F)F.[Ag+]>[O:2]=[C:3]([OH:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1=[CH:12][CH:13]([CH2:14][C:15]1=[O:16])[OH:1]|EP0133995B1_0080
10.1.1|[Br&H0&+0&D1:4]-Br.[n:3]:[c&H1&+0&D2:2]:[s:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[N:1]#[C:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[F:9])-[c:10]1[cH:11][n:12][cH:13][s:14]1.[Br:15]Br>[Na+].CC([O-])=O.CC(=O)O.[OH-].[K+]>[N:1]#[C:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[F:9])-[c:10]1[cH:11][n:12][c:13]([s:14]1)[Br:15]|US20200405696A1_0830
6.3.7|[C:4]-[C@&H1&+0&D3:3](-[O:2])-[O&H0&+0&D2:1]-C>>[C:4]-[C&H1&+0&D3:3](-[O:2])-[O&H1&+0&D1:1]|[CH3:1][C:2](=[O:3])[NH:4][CH2:5][C@H:6]1[O:7][C@@H:8]([CH2:9][CH2:10][C@@H:11]1[OH:12])[O:13]C>Cl.[O-]C([O-])=O>[CH3:1][C:2](=[O:3])[NH:4][CH2:5][C@H:6]1[O:7][CH:8]([CH2:9][CH2:10][C@@H:11]1[OH:12])[OH:13]|US05380834A
10.1.1|[Br&H0&+0&D1:4]-Br.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]1([CH2:3][C:4]([NH:5][NH:6]1)=[O:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[Br:20]Br>CC(=O)O>[CH3:1][C:2]1([CH2:3][C:4]([NH:5][NH:6]1)=[O:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Br:20]|EP3472161B1_0212
1.6.4|[#14:4]-[C&H2&+0&D2:3]-Cl.[C:2]-[N&H2&+0&D1:1]>>[#14:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:1]-[C:2]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5]Cl.[NH2:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>O[Na]>[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][NH:6][CH2:7][c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1|US10301286B2_0488
9.7.39|[N&H3&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH3:1].[CH3:2][CH2:3][CH:4]([CH2:5][CH3:6])[NH:7][c:8]1[c:9]([cH:10][c:11]([c:12]([c:13]1[N+:14]([O-:15])=[O:16])Cl)[CH3:17])[N+:18]([O-:19])=[O:20]>COCCOC>[CH3:2][CH2:3][CH:4]([CH2:5][CH3:6])[NH:7][c:8]1[c:9]([cH:10][c:11]([c:12]([c:13]1[N+:14]([O-:15])=[O:16])[NH2:1])[CH3:17])[N+:18]([O-:19])=[O:20]|US20200055851A1_0161
10.1.1|[Br&H0&+0&D1:4]-Br.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]1([CH2:10][CH2:11][C:12]([CH2:13][CH2:14]1)=[O:15])[C:16]([NH2:17])=[O:18].[Br:19]Br>O.O.CC(=O)O>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]1([CH2:14][CH2:13][C:12]([CH:11]([CH2:10]1)[Br:19])=[O:15])[C:16]([NH2:17])=[O:18]|EP3741392A1_0070
9.7.3|[Br&H0&-&D0:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-N>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[Br-:1].[Br-].[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]2[n:8][c:9]([s:10][c:11]2[cH:12]1)N.[Cu+2]>CC#N>[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]2[n:8][c:9]([s:10][c:11]2[cH:12]1)[Br:1]|EP3650449A1_0239
9.7.44|[O&H2&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[OH2:1].[CH3:2][c:3]1[n:4][n:5]([c:6]([c:7]1[C:8](=[O:9])[c:10]1[c:11]([cH:12][cH:13][cH:14][c:15]1[Cl:16])[Cl:17])Cl)[CH3:18]>CCO.O[K]>[CH3:2][c:3]1[n:4][n:5]([c:6]([c:7]1[C:8](=[O:9])[c:10]1[c:11]([cH:12][cH:13][cH:14][c:15]1[Cl:16])[Cl:17])[OH:1])[CH3:18]|US20200299258A1_0196
9.7.27|[O&H2&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[OH:1][CH:2]([c:3]1[cH:4][c:5]([n:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]12)Br)[CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1.[OH2:19]>CCCC[N+](CCCC)(CCCC)CCCC.C1COCCO1.Cl.[F-]>[OH:19][c:5]1[cH:4][c:3]([c:12]2[cH:11][cH:10][cH:9][cH:8][c:7]2[n:6]1)[CH:2]([OH:1])[CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1|EP3495360A1_0704
9.7.27|[O&H2&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[OH2:1].[NH2:2][c:3]1[n:4][cH:5][c:6]([cH:7][c:8]1Br)[Cl:9]>Cl.O[K].[Cu]>[NH2:2][c:3]1[n:4][cH:5][c:6]([cH:7][c:8]1[OH:1])[Cl:9]|EP3225618B1_0991
1.7.9|[#14:4]-[C&H2&+0&D2:3]-Cl.[O&H1&+0&D1:2]-[c:1]>>[#14:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[OH:8])[CH3:9])[OH:10].[CH3:11][Si:12]([CH3:13])([CH3:14])[CH2:15]Cl>O=C(O[K])O[K].CN(C)C=O.O.O>[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[OH:8])[CH3:9])[O:10][CH2:15][Si:12]([CH3:11])([CH3:13])[CH3:14]|US20150337062A1_0221
9.7.39|[N&H3&+0&D0:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[NH3:1].[O:2]=[c:3]1[nH:4][c:5]([n:6][c:7]2[c:8]1[n:9][cH:10][n:11]2[CH2:12][O:13][CH2:14][CH2:15][OH:16])Cl>CO>[NH2:1][c:5]1[n:6][c:7]2[c:8]([n:9][cH:10][n:11]2[CH2:12][O:13][CH2:14][CH2:15][OH:16])[c:3]([nH:4]1)=[O:2]|US20190337926A1_0616
10.1.1|[Br&H0&+0&D1:4]-Br.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][n:4][c:5]([cH:6][n:7]1)[NH2:8].[Br:9]Br>O.O.O.[Na+].CC(=O)O.CC([O-])=O.O[Na]>[CH3:1][c:2]1[cH:3][n:4][c:5]([c:6]([n:7]1)[Br:9])[NH2:8]|EP3230284B1_0215
1.8.13|[#14:4]-[C&H2&+0&D2:3]-Cl.[S&H1&+0&D1:2]-[c:1]>>[#14:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[SH:16].[CH3:17][Si:18]([CH3:19])([CH2:20]Cl)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>O=C(O[K])O[K].CN(C)C=O.O.O>[CH3:13][C:12]([CH3:14])([CH3:15])[c:9]1[cH:8][c:7]([cH:6][c:5]([c:10]1[OH:11])[C:2]([CH3:1])([CH3:3])[CH3:4])[S:16][CH2:20][Si:18]([CH3:17])([CH3:19])[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1|US09931407B2_0536
10.1.1|[Br&H0&+0&D1:4]-Br.[c:3]:[c&H1&+0&D2:2]:[o:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[o:9][cH:10][c:11]2-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[Br:18]Br>ClCCl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[o:9][c:10]([c:11]2-[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1)[Br:18]|US20120309739A1_0219
9.7.3|[Br&H0&-&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-N>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Br-:1].N[c:2]1[cH:3][cH:4][c:5]2[O:6][C:7]([C:8]([c:9]2[cH:10]1)([F:11])[F:12])([F:13])[F:14].[Cu+]>O.Br.O=NO[Na]>[F:13][C:7]1([O:6][c:5]2[cH:4][cH:3][c:2]([cH:10][c:9]2[C:8]1([F:11])[F:12])[Br:1])[F:14]|US20200040039A1_0592
10.1.1|[Br&H0&+0&D1:4]-Br.[C:3]=[C&H1&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:4]-[C&H0&+0&D3:2](=[C:3])-[C:1]|[CH3:1][c:2]1[cH:3][c:4]2[C:5]([CH:6]=[CH:7][C:8]([c:9]2[cH:10][c:11]1[CH3:12])=[O:13])=[O:14].[Br:15]Br>O.[Na+].CC([O-])=O.CC(=O)O>[CH3:12][c:11]1[cH:10][c:9]2[C:8]([C:7](=[CH:6][C:5]([c:4]2[cH:3][c:2]1[CH3:1])=[O:14])[Br:15])=[O:13]|US20090170926A1_0138
10.1.1|[Br&H0&+0&D1:4]-Br.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[N:1]#[C:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10].[Br:11]Br>c1ccccc1.Br>[N:1]#[C:2][CH:3]([Br:11])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10]|EP3331885B1_0280
9.7.22|[N&H3&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH3:1].[NH2:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][S:8][c:9]1[cH:10][cH:11][cH:12][c:13]([n:14]1)Br>O>[NH2:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][S:8][c:9]1[cH:10][cH:11][cH:12][c:13]([n:14]1)[NH2:1]|US20200347009A1_0545
4.2.35|[O&H1&+0&D1:4]-[C:3]-[C&H1&+0&D3:2](-[c:1])-O>>[O&H0&+0&D2:4]1-[C:3]-[C&H1&+0&D3:2]-1-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]([CH3:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[CH:17](O)[CH2:18][OH:19]>>[CH3:10][C@H:9]([NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[CH:17]1[CH2:18][O:19]1|US20040138462A1_0907
4.2.35|[C:4]-[C&H1&+0&D3:3](-[C:2]-[O&H1&+0&D1:1])-O>>[C:4]-[C&H1&+0&D3:3]1-[O&H0&+0&D2:1]-[C:2]-1|[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]([OH:12])[CH:13](O)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][OH:22]>O=C(O)CCCCCCCC=CCCCCCCCC(=O)O.O=C(O)CCCCCCCC=CCCCCCCCCO.O=C(O)CCCCCCCCCCCCCCCCCCCCC(=O)O.O=C(O)CCCCCCCCCCCCCCCCCCCCCO.O=C(O)CCCCCCCC(O)CCCCCCCO>[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]1[O:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][OH:22]|US07799785B2_0442
9.7.39|[N&H3&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH3:1].[CH3:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[Cl:9])[CH:10]([CH3:11])[n:12]1[nH:13][c:14]([cH:15][c:16]1=[O:17])Cl>CCO>[CH3:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[Cl:9])[CH:10]([CH3:11])[n:12]1[nH:13][c:14]([cH:15][c:16]1=[O:17])[NH2:1]|EP2578584B1_0077
9.7.44|[O&H2&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][c:8]([c:9]1Cl)[C:10]([F:11])([F:12])[F:13])[C:14]([F:15])([F:16])[F:17].[OH2:18]>CO.O[Na].ClCl>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][c:8]([c:9]1[OH:18])[C:10]([F:11])([F:12])[F:13])[C:14]([F:15])([F:16])[F:17]|EP3536691A1_0089
9.7.267|[Cl&H0&-&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[Cl&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Cl-:1].[CH3:2][N:3]1[CH2:4][CH2:5][c:6]2[c:7]([s:8][cH:9][c:10]2Br)[CH:11]([CH2:12]1)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>CN(C)C=O.[Cu]>[CH3:2][N:3]1[CH2:12][CH:11]([c:7]2[s:8][cH:9][c:10]([c:6]2[CH2:5][CH2:4]1)[Cl:1])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US20200339590A1_1177
4.2.35|[C:4]-[C&H1&+0&D3:3](-[C:2]-[O&H1&+0&D1:1])-Cl>>[C:4]-[C&H1&+0&D3:3]1-[O&H0&+0&D2:1]-[C:2]-1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[CH2:9][CH2:10]/[CH:11]=[CH:12]\[CH:13]([OH:14])[CH:15](Cl)[CH2:16][CH3:17]>CC(C)(C)O.CC(C)(C)[O-].[O-]P(=O)(O)O.O.[Na+].[K+]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[CH2:9][CH2:10]/[CH:11]=[CH:12]\[CH:13]1[O:14][CH:15]1[CH2:16][CH3:17]|EP3458468B1_0350
9.7.3|[Br&H1&+0&D0:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-N>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|N[c:1]1[n:2][n:3][c:4]([s:5]1)[C:6]([F:7])([F:8])[F:9].[BrH:10]>O=S(O)O[Na].[O-]N=O.[Na+].[Na+].[OH-].[Cu]>[F:7][C:6]([F:8])([F:9])[c:4]1[n:3][n:2][c:1]([s:5]1)[Br:10]|EP3356361B1_0215
9.1.5|[Br&H1&+0&D0:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-O>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[c:3])-[c:1]|[BrH:1].[O-:2][N+:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[Cl:11])[CH:12](O)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>O>[O-:2][N+:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[Cl:11])[CH:12]([Br:1])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|EP2686298B1_0111
4.2.35|[C:4]-[C&H1&+0&D3:3](-[C:2]-[O&H1&+0&D1:1])-Br>>[C:4]-[C&H1&+0&D3:3]1-[O&H0&+0&D2:1]-[C:2]-1|Br.[CH3:1][N:2]1[CH2:3][CH:4]([C:5]([CH2:6][CH2:7]1)([OH:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)Br>O.O=C(O[K])O[K].O[Na]>[CH3:1][N:2]1[CH2:3][CH:4]2[O:8][C:5]2([CH2:6][CH2:7]1)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|EP0244717A2_0037
9.7.3|[Br&H1&+0&D0:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-N>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[BrH:1].N[c:2]1[n:3][cH:4][c:5]2[nH:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[c:13]2[n:14]1>O=NO[Na].Br[Cu]>[Br:1][c:2]1[n:3][cH:4][c:5]2[nH:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[c:13]2[n:14]1|US20130005707A1_1720
9.5.4|[N&+:4]-[C&H2&+0&D2:3]-[C&H1&+0&D3:2](-[c:1])-O>>[N&+:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]|[O-:1][N+:2](=[O:3])[CH2:4][CH:5](O)[c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[O:12][CH2:13][C:14]([F:15])([F:16])[F:17]>CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.ClCCl>[O-:1][N+:2](=[O:3])[CH:4]=[CH:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[O:12][CH2:13][C:14]([F:15])([F:16])[F:17]|US20200061041A1_0627
9.7.3|[Br&H1&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-N>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[BrH:1].N[c:2]1[cH:3][c:4]2[c:5]3[cH:6][cH:7][cH:8][cH:9][c:10]3[nH:11][c:12]2[cH:13][n:14]1>O=NO[Na]>[Br:1][c:2]1[cH:3][c:4]2[c:5]3[cH:6][cH:7][cH:8][cH:9][c:10]3[nH:11][c:12]2[cH:13][n:14]1|US20200172546A1_0987
9.5.4|[C:4]-[C&H1&+0&D3:3](-[C&H2&+0&D2:2]-[N&+:1])-O>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[N&+:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH2:12][CH2:13][CH:14](O)[CH2:15][N+:16]([O-:17])=[O:18]>CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH2:12][CH2:13][CH:14]=[CH:15][N+:16]([O-:17])=[O:18]|US09624228B2_2451
3.11.31|[C&H3&+0&D1:4]-[N&+:3].[c:2]-[C&H1&+0&D2:1]=O>>[C&H1&+0&D2:4](-[N&+:3])=[C&H1&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[c:4]([cH:5][c:6]2[CH2:7][CH2:8][CH2:9][c:10]2[c:11]1[O:12][CH3:13])[CH:14]=O.[CH3:15][N+:16]([O-:17])=[O:18]>[NH4+].CC([O-])=O.CC(=O)O>[CH3:1][O:2][c:3]1[c:11]([c:10]2[CH2:9][CH2:8][CH2:7][c:6]2[cH:5][c:4]1[CH:14]=[CH:15][N+:16]([O-:17])=[O:18])[O:12][CH3:13]|US08946260B2_0942
3.11.31|[C&H3&+0&D1:4]-[N&+:3].[C:2]-[C&H1&+0&D2:1]=O>>[C&H1&+0&D2:4](\[N&+:3])=[C&H1&+0&D2:1]/[C:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[C@H:16]([CH2:17][CH2:18][CH:19]=O)[C:20](=[O:21])[O:22][CH2:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1.[CH3:30][N+:31]([O-:32])=[O:33]>Cc1ccccc1.CCN(CC)CC.CS(=O)(=O)Cl.N=C(N)N>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[C@H:16]([CH2:17][CH2:18]/[CH:19]=[CH:30]/[N+:31]([O-:32])=[O:33])[C:20](=[O:21])[O:22][CH2:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1|US09650334B2_3140
9.7.3|[Br&H1&+0&D0:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-N>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH2:1]=[CH:2][CH2:3][C@@H:4]1[CH:5]([C:6]([N:7]1[C:8](=[C:9]([CH3:10])[CH3:11])[C:12](=[O:13])[O:14][CH3:15])=[O:16])N.CCN(CC)CC.[BrH:17]>Cc1ccc(cc1)S(=O)(=O)O.CC(C)CCON=O.ClCCl.O>[CH2:1]=[CH:2][CH2:3][C@@H:4]1[CH:5]([C:6]([N:7]1[C:8](=[C:9]([CH3:10])[CH3:11])[C:12](=[O:13])[O:14][CH3:15])=[O:16])[Br:17]|US05264429A
9.5.4|[C&H3&+0&D1:4]-[C&H0&+0&D4:3](-[C:2])(-[N:1])-O>>[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C:2])-[N:1]|[CH3:1][C:2]1([C:3]2[CH2:4][CH2:5][CH2:6][CH2:7][C:8]=2[C:9]([N:10]1[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[F:17])[Cl:18])=[O:19])O>[O-]S(=O)(=O)O.ClC(Cl)Cl.[K+]>[CH2:1]=[C:2]1[C:3]2[CH2:4][CH2:5][CH2:6][CH2:7][C:8]=2[C:9]([N:10]1[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[F:17])[Cl:18])=[O:19]|US20180244616A1_0055
2.5.7|[N&H3&+0&D0:4].[N:3]-[C&H0&+0&D3:2](=[N:1])-S-C>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](-[N:3])=[N:1]|[NH3:1].[IH:2].CS[C:3]1=[N:4][CH2:5][CH:6]([N:7]1[CH2:8][CH2:9][OH:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17]>CO>[IH:2].[NH2:1][C:3]1=[N:4][CH2:5][CH:6]([N:7]1[CH2:8][CH2:9][OH:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17]|US08450308B2_1201
9.5.4|[C&H3&+0&D1:4]-[C&H0&+0&D4:3](-[C:2])(-[c:1])-O>>[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]|[CH3:1][C:2](O)([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]2-[c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][c:17]2[cH:18]1>C1COCCO1.O=S(=O)(O)O.O>[CH2:1]=[C:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]2-[c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][c:17]2[cH:18]1|US09505765B2_0412
1.2.9|[C&H3&+0&D1:4]-[O&-].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&+0&D1:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][O-].[O:2]=[c:3]1[nH:4][c:5]([n:6][o:7]1)[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>O.CO.CI>[CH3:1][n:4]1[c:5]([n:6][o:7][c:3]1=[O:2])[CH2:8][c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1|EP0217748A2_0114
1.3.11|[N&H2&+0&D1:4]-[#11].[c:3]:[c&H1&+0&D2:2]:[n:1]>>[N&H2&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][Na].[cH:2]1[cH:3][cH:4][c:5]([cH:6][n:7]1)-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>>[NH2:1][c:6]1[n:7][cH:2][cH:3][cH:4][c:5]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|EP2378582B1_0064
9.5.4|[C&H3&+0&D1:4]-[C&H0&+0&D4:3](-[C:2])(-[C:1])-O>>[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C:2])-[C:1]|[CH3:1][C:2]1([CH2:3][CH2:4][C:5]([C:6]1([CH3:7])O)([CH3:8])[CH3:9])[CH3:10]>c1ccncc1.O=S(Cl)Cl>[CH2:7]=[C:6]1[C:5]([CH2:4][CH2:3][C:2]1([CH3:1])[CH3:10])([CH3:8])[CH3:9]|EP0990634B1_0135
9.5.4|[C&H3&+0&D1:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-O>>[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH:6]1[CH2:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[C:14]([c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21)([CH3:21])O>O=S(=O)(O)O.O[K].ClCCl>[CH2:21]=[C:14]1[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[CH:6]([CH2:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]12)[CH2:5][CH2:4][N:2]([CH3:1])[CH3:3]|US20050250822A1_0721
9.7.3|[Br&H1&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-N>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[BrH:1].[CH3:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[N+:9]([O-:10])=[O:11])[O:12][CH3:13])N>O.CC(=O)O.O=NO[Na].Br[Cu]>[CH3:13][O:12][c:6]1[cH:7][c:8]([c:3]([cH:4][c:5]1[Br:1])[CH3:2])[N+:9]([O-:10])=[O:11]|EP3339303B1_0522
9.7.222|[C:4]-[S&H0&+0&D2:3]-[#19].[C:2]-[C&H2&+0&D2:1]-I>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[N:1]#[C:2][S:3][K].[O:4]=[C:5]1[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[C:12]([N:13]1[C@@H:14]1[C:15]([NH:16][C@@H:17]1[CH2:18]I)=[O:19])=[O:20]>O.CN(C)C=O>[N:1]#[C:2][S:3][CH2:18][C@H:17]1[NH:16][C:15]([C@H:14]1[N:13]1[C:12]([c:11]2[cH:10][cH:9][cH:8][cH:7][c:6]2[C:5]1=[O:4])=[O:20])=[O:19]|US20090137773A1_0103
9.7.194|[C&H3&D1:4]-[C&H0&+0&D4:3](-[C:2])(-[C:1])-C(-O)=O>>[C&H3&D1:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][C:2]1[CH2:3][C:4]([C:5]([C:6]=1[OH:7])=[O:8])([CH3:9])C(=O)O>O=S(=O)(O)O.O[Na]>[CH3:1][C:2]1[CH2:3][CH:4]([C:5]([C:6]=1[OH:7])=[O:8])[CH3:9]|US08552027B2_0169
9.1.5|[Br&H1&+0&D0:4].[C:3]-[C&H1&+0&D3:2](-[O:1])-O>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[O:1]|[BrH:1].CC(=O)O[O].[OH:2][CH2:3][C@H:4]1[O:5][C@H:6]([C@@H:7]([C@H:8]([C@H:9]1[OH:10])[OH:11])[OH:12])[O:13][C@@H:14]1[C@H:15]([O:16][CH:17]([C@@H:18]([C@H:19]1[OH:20])[OH:21])O)[CH2:22][OH:23]>O.CCOCC.ClCCl>[OH:2][CH2:3][C@H:4]1[O:5][C@H:6]([C@@H:7]([C@H:8]([C@H:9]1[OH:10])[OH:11])[OH:12])[O:13][C@@H:14]1[C@H:15]([O:16][CH:17]([C@@H:18]([C@H:19]1[OH:20])[OH:21])[Br:1])[CH2:22][OH:23]|US20190382406A1_0489
10.1.1|[Br&H0&+0&D1:3]-N1-C(=O)-C-C-C-1=O.[C&H1&+0&D1:2]#[C:1]>>[Br&H0&+0&D1:3]-[C&H0&+0&D2:2]#[C:1]|[CH:1]#[C:2][CH2:3][C@@:4]12[CH2:5][CH2:6][C:7]([CH:8]=[C:9]2[C:10]([CH2:11][C@H:12]2[C@@H:13]3[CH2:14][CH2:15][C:16]([C@:17]3([CH2:18][CH2:19][C@@H:20]21)[CH3:21])=[O:22])=[CH2:23])=[O:24].O=C1CCC(N1[Br:25])=O>O.O.CC(C)=O.[O-][N+](=O)O[Ag]>[CH2:23]=[C:10]1[CH2:11][C@H:12]2[C@@H:13]3[CH2:14][CH2:15][C:16]([C@:17]3([CH2:18][CH2:19][C@@H:20]2[C@:4]2([CH2:5][CH2:6][C:7]([CH:8]=[C:9]12)=[O:24])[CH2:3][C:2]#[C:1][Br:25])[CH3:21])=[O:22]|US20200277259A1_0694
2.6.2|[C:4]-[O&H0&+0&D2:3]-[#11].[C:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])[O:4][Na].[OH:5][CH:6]1[CH:7]([CH:8]([O:9][CH:10]([CH:11]1[OH:12])[O:13][C:14]1([O:15][CH:16]([CH:17]([CH:18]1[OH:19])[OH:20])[CH2:21][Cl:22])[CH2:23][Cl:24])[CH2:25]Cl)[Cl:26]>CN(C)C=O>[CH3:1][C:2](=[O:3])[O:4][CH2:25][CH:8]1[O:9][CH:10]([CH:11]([CH:6]([CH:7]1[Cl:26])[OH:5])[OH:12])[O:13][C:14]1([O:15][CH:16]([CH:17]([CH:18]1[OH:19])[OH:20])[CH2:21][Cl:22])[CH2:23][Cl:24]|EP3042900B1_0533
2.6.2|[C:4]-[O&H0&+0&D2:3]-[#11].[c:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|Br[CH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH2:8][P+:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[CH2:28]=[C:29]([CH3:30])[C:31](=[O:32])[O:33][Na].[Br-:34]>CCO.CC#N.O>[CH2:28]=[C:29]([CH3:30])[C:31](=[O:32])[O:33][CH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH2:8][P+:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1.[Br-:34]|EP3394059B1_0481
2.6.2|[C:4]-[O&H0&+0&D2:3]-[#19].[c:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2](=[O:3])[O:4][K].[O-:5][N+:6](=[O:7])[c:8]1[cH:9][cH:10][cH:11][c:12]([c:13]1[CH2:14]Br)[Br:15]>>[CH3:1][C:2](=[O:3])[O:4][CH2:14][c:13]1[c:12]([cH:11][cH:10][cH:9][c:8]1[N+:6]([O-:5])=[O:7])[Br:15]|EP3417851B1_0345
2.6.2|[C:4]-[O&H0&+0&D2:3]-[#11].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C@@H:2]([OH:3])[C@H:4]1[C:5]([N:6]2[C:7](=[C:8]([S:9][C@H:10]12)[C@H:11]1[CH2:12][CH2:13][CH2:14][O:15]1)[C:16](=[O:17])[O:18][Na])=[O:19].[CH3:20][c:21]1[o:22][c:23]([o:24][c:25]1[CH2:26]Cl)=[O:27]>CCCC[N+](CCCC)(CCCC)Cc1ccccc1.C1CCOC1.[Cl-]>[CH3:20][c:21]1[o:22][c:23]([o:24][c:25]1[CH2:26][O:18][C:16](=[O:17])[C:7]1=[C:8]([S:9][C@@H:10]2[C@H:4]([C:5]([N:6]12)=[O:19])[C@@H:2]([CH3:1])[OH:3])[C@H:11]1[CH2:12][CH2:13][CH2:14][O:15]1)=[O:27]|US10845703B2_0200
3.11.16|[C&H3&+0&D1:4]-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([O:7][CH2:8][C@@H:9]3[CH2:10][CH2:11][N:12]([CH2:13][C@H:14]23)[CH3:15])[c:16]([cH:17]1)Br.[CH3:18]I>O.CCOC(C)=O.CCCC[Li].C1CCOC1>[CH3:1][O:2][c:3]1[cH:17][c:16]([c:6]2[O:7][CH2:8][C@@H:9]3[CH2:10][CH2:11][N:12]([CH2:13][C@@H:14]3[c:5]2[cH:4]1)[CH3:15])[CH3:18]|US20200360379A1_1060
3.11.16|[C&H3&+0&D1:4]-I.[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C&H3&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1]I.Br[c:2]1[cH:3][cH:4][c:5]([s:6]1)[CH:7]=[CH:8][c:9]1[cH:10][s:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21>O.CCOCC.CCCC[Li]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([s:6]1)[CH:7]=[CH:8][c:9]1[cH:10][s:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]12|US08022209B2_0916
9.7.320|[C:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-[#34]-c1:c:c:c:c:c:1>>[C:3]-[C&H1&+0&D2:2]=[C&H2&+0&D1:1]|[CH3:1][C:2](=[O:3])[O:4][C@H:5]1[CH:6]2[CH2:7][CH2:8][C:9]3([O:10][CH2:11][CH2:12][O:13]3)[C@:14]2([CH2:15][CH2:16][CH:17]1[C@:18]1([CH2:19][CH2:20][C@@H:21]([CH2:22][C@@H:23]1[CH2:24][CH2:25][Se]c1ccccc1)[O:26][Si:27]([CH3:28])([CH3:29])[C:30]([CH3:31])([CH3:32])[CH3:33])[CH3:34])[CH3:35]>>[CH2:25]=[CH:24][C@H:23]1[CH2:22][C@H:21]([CH2:20][CH2:19][C@:18]1([CH3:34])[CH:17]1[CH2:16][CH2:15][C@:14]2([CH:6]([CH2:7][CH2:8][C:9]22[O:10][CH2:11][CH2:12][O:13]2)[C@@H:5]1[O:4][C:2]([CH3:1])=[O:3])[CH3:35])[O:26][Si:27]([CH3:28])([CH3:29])[C:30]([CH3:31])([CH3:32])[CH3:33]|US20090099250A1_0451
10.1.15|[Cl&H0&+0&D1:3]-N1-C(=O)-C-C-C-1=O.[S&H1&+0&D1:2]-[c:1]>>[Cl&H0&+0&D1:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[SH:8].O=C1CCC(N1[Cl:9])=O>c1ccccc1>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[S:8][Cl:9]|US20090192190A1_0642
2.6.2|[C:4]-[O&H0&+0&D2:3]-[#19].[C:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])[O:4][K].[F:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH:12]([CH2:13][CH2:14][CH2:15]Cl)[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22]>>[CH3:1][C:2](=[O:3])[O:4][CH2:15][CH2:14][CH2:13][CH:12]([c:9]1[cH:8][cH:7][c:6]([cH:11][cH:10]1)[F:5])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22]|US20200331860A1_0473
2.6.2|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[O&H0&+0&D2:1]-[#11]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[C:6](=[CH:7][C:8]([N:9]([c:10]2[cH:11]1)[C:12]([CH3:13])=[O:14])([CH3:15])[CH3:16])[CH2:17]Br.[CH3:18][C:19](=[O:20])[O:21][Na]>>[CH3:18][C:19](=[O:20])[O:21][CH2:17][C:6]1=[CH:7][C:8]([N:9]([c:10]2[cH:11][c:2]([cH:3][cH:4][c:5]12)[CH3:1])[C:12]([CH3:13])=[O:14])([CH3:15])[CH3:16]|US20030162992A1_0113
9.7.267|[Cl&H1&+0&D0:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[Cl&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][c:7]2[C:8]([c:9]3[cH:10][cH:11][cH:12][c:13]([c:14]3[CH2:15][CH2:16][c:17]2[cH:18]1)Br)=[O:19].[ClH:20]>CN1CCCC1=O.Cl[Fe](Cl)Cl.Cl[Cu].O.O.O.O.O.O.O>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][c:7]2[C:8]([c:9]3[cH:10][cH:11][cH:12][c:13]([c:14]3[CH2:15][CH2:16][c:17]2[cH:18]1)[Cl:20])=[O:19]|US20100227887A1_0153
9.7.219|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[S&H0&+0&D2:1]-[#19]>>[C:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:1]-[C:2]|[CH3:1][C:2]1([S:3][C@@H:4]2[CH:5]([C:6]([N:7]2[CH:8]1[C:9](=[O:10])[O:11][CH2:12][C:13]([Cl:14])([Cl:15])[Cl:16])=[O:17])[NH:18][C:19](=[O:20])[CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[CH2:28]Br.[N:29]#[C:30][S:31][K]>CC(C)=O.O>[CH3:1][C:2]1([S:3][C@@H:4]2[CH:5]([C:6]([N:7]2[CH:8]1[C:9](=[O:10])[O:11][CH2:12][C:13]([Cl:14])([Cl:15])[Cl:16])=[O:17])[NH:18][C:19](=[O:20])[CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[CH2:28][S:31][C:30]#[N:29]|EP0244962A1_0057
2.6.2|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[O&H0&+0&D2:1]-[#19]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH2:1]=[CH:2][C:3](=[CH2:4])[CH2:5]Br.[CH3:6][C:7](=[O:8])[O:9][K]>CN(C)C=O>[CH2:1]=[CH:2][C:3](=[CH2:4])[CH2:5][O:9][C:7]([CH3:6])=[O:8]|EP3359541B1_0678
10.1.5|[Br&H0&+0&D1:3]-N1-C(=O)-C-C-C-1=O.[C&H3&+0&D1:2]-[c:1]>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])[Br:11].O=C1CCC(N1[Br:12])=O>O=C(OOC(=O)c1ccccc1)c1ccccc1.ClC(Cl)(Cl)Cl>[O-:9][N+:8](=[O:10])[c:7]1[cH:6][cH:5][cH:4][c:3]([c:2]1[CH2:1][Br:12])[Br:11]|EP3442945B1_0301
9.7.220|[C:4]-[S&H0&+0&D2:3]-[#19].[C:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[N:1]#[C:2][S:3][K].[O:4]=[C:5]([CH2:6]Cl)[N:7]1[CH2:8][CH2:9][CH2:10][CH2:11]1>CCCCC.CCO>[N:1]#[C:2][S:3][CH2:6][C:5](=[O:4])[N:7]1[CH2:8][CH2:9][CH2:10][CH2:11]1|US20040204590A1_0118
9.7.252|[C:3]-[C&H1&+0&D3:2](-[F&H0&D1:1])-S(=O)(=O)-c1:c:c:c:c:c:1>>[C:3]-[C&H2&+0&D2:2]-[F&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([CH2:11]1)([CH:12]([F:13])S(=O)(=O)c1ccccc1)[n:14]1[cH:15][c:16]([cH:17][n:18]1)-[c:19]1[n:20][cH:21][n:22][c:23]2[c:24]1[cH:25][cH:26][n:27]2[CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:33])([CH3:34])[CH3:35]>CCOC(C)=O.[O-]P([O-])(=O)O.CO.[Na+].[Na+].[Na].[Hg]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([CH2:11]1)([CH2:12][F:13])[n:14]1[cH:15][c:16]([cH:17][n:18]1)-[c:19]1[n:20][cH:21][n:22][c:23]2[c:24]1[cH:25][cH:26][n:27]2[CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:33])([CH3:34])[CH3:35]|US20200147062A1_0302
10.1.5|[Br&H0&+0&D1:3]-N1-C(=O)-C-C-C-1=O.[C&H3&+0&D1:2]-[C:1]>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][CH:2]=[CH:3][c:4]1[n:5][c:6]2[cH:7][cH:8][c:9]([cH:10][c:11]2[c:12]([nH:13]1)=[O:14])[CH3:15].O=C1CCC(N1[Br:16])=O>O=C(OOC(=O)c1ccccc1)c1ccccc1.ClC(Cl)(Cl)Cl>[CH3:15][c:9]1[cH:8][cH:7][c:6]2[n:5][c:4]([nH:13][c:12]([c:11]2[cH:10]1)=[O:14])[CH:3]=[CH:2][CH2:1][Br:16]|EP3628672A1_0191
3.9.44|[C&H3&+0&D1:4]-C(-O)=O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1]C(=O)O.[O:2]=[C:3]([OH:4])[CH2:5][c:6]1[cH:7][cH:8][c:9]2[c:10]([cH:11]1)[CH2:12][c:13]1[cH:14][c:15]([cH:16][cH:17][c:18]1-2)[OH:19]>C=[N+]=[N-].CO.CCOCC>[CH3:1][c:11]1[c:6]([cH:7][cH:8][c:9]2[c:10]1[CH2:12][c:13]1[cH:14][c:15]([cH:16][cH:17][c:18]1-2)[OH:19])[CH2:5][C:3](=[O:2])[OH:4]|US20190382358A1_0555
9.7.70|[N&H2&+0&D1:4]-C(-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[N&H2&+0&D1:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1]C(=O)[c:2]1[cH:3][c:4]([cH:5][nH:6][c:7]1=[O:8])-[c:9]1[cH:10][cH:11][n:12][cH:13][cH:14]1>>[NH2:1][c:2]1[cH:3][c:4]([cH:5][nH:6][c:7]1=[O:8])-[c:9]1[cH:10][cH:11][n:12][cH:13][cH:14]1|US20200165256A1_0522
8.6.1|[C:4]-[C&H2&+0&D2:3]-[C:2].[O&H0&+0&D1:1]=[#34]=O>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH:3]1[CH:4]=[C:5]([CH2:6][CH:7]([CH2:8][CH:9]([CH:10]2[O:11][C:12]([C:13]([C:14]([N:15]3[CH2:16][CH2:17][CH2:18][CH2:19][CH:20]3[C:21]([O:22][CH:23]([CH:24]([CH:25]([CH2:26][C:27]1=[O:28])[OH:29])[CH3:30])[C:31]([CH3:32])=[CH:33][CH:34]1[CH2:35][CH2:36][CH:37]([CH:38]([CH2:39]1)[O:40][CH3:41])[OH:42])=[O:43])=[O:44])=[O:45])([CH:46]([CH2:47][CH:48]2[O:49][CH3:50])[CH3:51])[OH:52])[O:53][CH3:54])[CH3:55])[CH3:56].O=[Se]=[O:57]>O.CC(=O)O>[CH3:50][O:49][CH:48]1[CH2:47][CH:46]([C:12]2([O:11][CH:10]1[CH:9]([CH2:8][CH:7]([CH:6]([C:5](=[CH:4][CH:3]([C:27]([CH2:26][CH:25]([CH:24]([CH:23]([O:22][C:21]([CH:20]1[CH2:19][CH2:18][CH2:17][CH2:16][N:15]1[C:14]([C:13]2=[O:45])=[O:44])=[O:43])[C:31]([CH3:32])=[CH:33][CH:34]1[CH2:35][CH2:36][CH:37]([CH:38]([CH2:39]1)[O:40][CH3:41])[OH:42])[CH3:30])[OH:29])=[O:28])[CH2:2][CH3:1])[CH3:56])[OH:57])[CH3:55])[O:53][CH3:54])[OH:52])[CH3:51]|US20070142345A1_0283
9.7.99|[I&H0&+0&D1:4]-C-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-N>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)N.IC[I:14]>CCOCC.CC(C)CCON=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[I:14]|EP2831053B1_0587
8.8.14|[C:4]-[C&H2&+0&D2:3]-[c:2].[O&H0&+0&D1:1]=[#34]=O>>[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:1])-[c:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][s:9][c:10]([n:11]1)[NH:12][S:13]([CH3:14])(=[O:15])=[O:16].O=[Se]=[O:17]>C1COCCO1.O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:17])[c:7]1[cH:8][s:9][c:10]([n:11]1)[NH:12][S:13]([CH3:14])(=[O:15])=[O:16]|US20200188370A1_0963
10.1.1|[Br&H0&+0&D1:4]-[#11].[c:3]:[c&H1&+0&D2:2]:[c:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][n:2]1[n:3][c:4]([cH:5][c:6]1[C:7]([F:8])([F:9])[F:10])-[c:11]1[cH:12][c:13]([c:14]([cH:15][c:16]1[F:17])[Cl:18])[C:19](=[O:20])[OH:21].[Br:22][Na]>CC(=O)O.FF.ClCl.O>[CH3:1][n:2]1[n:3][c:4]([c:5]([c:6]1[C:7]([F:8])([F:9])[F:10])[Br:22])-[c:11]1[cH:12][c:13]([c:14]([cH:15][c:16]1[F:17])[Cl:18])[C:19](=[O:20])[OH:21]|US20190284192A1_1003
10.1.1|[Br&H0&+0&D1:4]-[#19].[c:3]:[c&H1&+0&D2:2]:[n:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][n:5]2[cH:6][cH:7][n:8][c:9]2[n:10]1.[Br:11][K]>[Na+].CO.CC([O-])=O.BrBr>[CH3:1][c:2]1[cH:3][cH:4][n:5]2[c:9]([n:10]1)[n:8][cH:7][c:6]2[Br:11]|EP2460805A1_0582
9.7.70|[N&H2&+0&D1:4]-C(-[c&H0&+0&D3:3](:[c:2]):[n:1])=O>>[N&H2&+0&D1:4]-[c&H0&+0&D3:3](:[c:2]):[n:1]|[NH2:1]C(=O)[c:2]1[n:3][s:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12>N.CCOC(N)=O.[N-]=[N+]=[N-].NO.OO>[NH2:1][c:2]1[n:3][s:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21|EP2727910B1_0307
10.1.1|[Br&H0&+0&D1:4]-[#19].[c:3]:[c&H1&+0&D2:2]:[c:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[n:6][c:7]3[CH2:8][CH2:9][CH2:10][n:11]3[c:12]2[cH:13]1.[Br:14][K]>O.CO.CC(=O)O.O=C(O)O[Na].ClC(Cl)Cl.BrBr>[CH3:1][c:2]1[cH:13][c:12]2[c:5]([cH:4][c:3]1[Br:14])[n:6][c:7]1[CH2:8][CH2:9][CH2:10][n:11]12|US20110207704A1_0792
9.7.99|[I&H0&+0&D1:4]-C-I.[n:3]:[c&H0&+0&D3:2](:[n:1])-N>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][C:2](=[O:3])[O:4][C@@H:5]1[C@@H:6]([C@H:7]([O:8][C@H:9]1[n:10]1[cH:11][n:12][c:13]2[c:14]([n:15][c:16]([n:17][c:18]21)N)[Cl:19])[CH2:20][O:21][C:22]([CH3:23])=[O:24])[O:25][C:26]([CH3:27])=[O:28].IC[I:29]>[Na+].[Na+].CC(C)CCON=O.[O-]S([O-])(=O)=S.II.I[Cu].C1CCOC1>[CH3:23][C:22](=[O:24])[O:21][CH2:20][C@H:7]1[O:8][C@H:9]([C@@H:5]([C@@H:6]1[O:25][C:26]([CH3:27])=[O:28])[O:4][C:2]([CH3:1])=[O:3])[n:10]1[cH:11][n:12][c:13]2[c:14]([n:15][c:16]([n:17][c:18]21)[I:29])[Cl:19]|EP1836174B2_0272
9.7.265|[C:4](-[C:3]-[N&H1&+0&D2:2]-C=O)-[O&H0&+0&D2:1]-C>>[C:4](-[C:3]-[N&H2&+0&D1:2])-[O&H1&+0&D1:1]|C[O:1][C:2](=[O:3])[CH:4]([CH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[n:12]1[cH:13][cH:14][cH:15][cH:16]1)[NH:17]C=O>[NH4+].[Na+].CO.[OH-].[OH-]>[NH2:17][CH:4]([CH2:5][c:6]1[cH:11][cH:10][c:9]([cH:8][cH:7]1)-[n:12]1[cH:16][cH:15][cH:14][cH:13]1)[C:2](=[O:3])[OH:1]|EP1471054A1_0472
8.8.14|[O&H0&+0&D1:4]=[#34]=O.[c:3]-[C&H2&+0&D2:2]-[c:1]>>[O&H0&+0&D1:4]=[C&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][c:10]1[cH:11][cH:12][cH:13][c:14]2[c:15]1[CH2:16][CH2:17][CH:18]2[C:19]#[N:20].O=[Se]=[O:21]>C1COCCO1.O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=[O:21])[c:10]1[cH:11][cH:12][cH:13][c:14]2[c:15]1[CH2:16][CH2:17][CH:18]2[C:19]#[N:20]|US07067529B2_0426
9.7.99|[I&H0&+0&D1:4]-C-I.[c:3]:[c&H0&+0&D3:2](:[n:1])-N>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[n:11]1[n:12][c:13]([c:14]2[CH:15]=[CH:16][C:17]([CH2:18][c:19]21)([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)N.IC[I:32]>CC(C)CCON=O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[n:11]1[n:12][c:13]([c:14]2[CH:15]=[CH:16][C:17]([CH2:18][c:19]21)([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[I:32]|EP3227286B1_0245
8.8.17|[O&H1&+0&D1:4]-O.[c:3]:[c&H0&+0&D3:2](:[c:1])-C=O>>[O&H1&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[OH:9])C=O.[OH:10]O>O.[Na+].[Na+].[O-]S(=O)S([O-])=O.O=S(=O)(O[Na])O[Na].O[Na]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[OH:9])[OH:10]|US20160185745A1_0179
9.1.5|[Br&H0&+0&D1:3]-N1-C(=O)-C-C-C-1=O.[c:2]-[C&H2&+0&D2:1]-O>>[Br&H0&+0&D1:3]-[C&H2&+0&D2:1]-[c:2]|O[CH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[CH:8]1[O:9][CH2:10][CH2:11][O:12]1.O=C1CCC(N1[Br:13])=O>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCN(CC)CC.ClCCl>[Br:13][CH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[CH:8]1[O:9][CH2:10][CH2:11][O:12]1|EP2542537B1_0199
10.1.2|[C&H2&+0&D1:3]=[C:2].[Cl&H0&+0&D1:1]-N1-C(=O)-C-C-C-1=O>>[C&H1&+0&D2:3](=[C:2])-[Cl&H0&+0&D1:1]|[CH2:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][cH:11][c:12]2[n:13][c:14]([n:15]([c:16]2[cH:17]1)[S:18](=[O:19])(=[O:20])[CH:21]([CH3:22])[CH3:23])[NH2:24].O=C1CCC(N1[Cl:25])=O>C1CCOC1>[CH3:22][CH:21]([CH3:23])[S:18](=[O:19])(=[O:20])[n:15]1[c:14]([n:13][c:12]2[cH:11][cH:10][c:9]([cH:17][c:16]21)[C:2](=[CH:1][Cl:25])[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[NH2:24]|US20040110787A1_0351
9.7.73|[C:4]-[C&H2&+0&D2:3]-O.[N&+:2]=[N&H0&+0&D2:1]-[#3]>>[C:4]-[C&H2&+0&D2:3]-[N&H0&+0&D2:1]=[N&+:2]|[O:1]=[c:2]1[nH:3][c:4]([n:5]([cH:6][c:7]1[CH2:8][CH2:9][Cl:10])[C@H:11]1[CH2:12][C@@H:13]([C@H:14]([O:15]1)[CH2:16]O)[OH:17])=[O:18].[N-:19]=[N+:20]=[N:21][Li]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CN(C)C=O.BrC(Br)(Br)Br.CO>[N-:19]=[N+:20]=[N:21][CH2:16][C@H:14]1[O:15][C@H:11]([CH2:12][C@@H:13]1[OH:17])[n:5]1[cH:6][c:7]([c:2]([nH:3][c:4]1=[O:18])=[O:1])[CH2:8][CH2:9][Cl:10]|US08492537B2_0188
9.7.3|[Br&H0&+0&D1:4]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-N>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|N[c:1]1[cH:2][cH:3][c:4]([cH:5][n:6]1)[S:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[Br:14]Br>O.Br.O=NO[Na].O[Na]>[Br:14][c:1]1[cH:2][cH:3][c:4]([cH:5][n:6]1)[S:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US09499514B2_1226
10.1.2|[C&H3&+0&D1:3]-[C:2].[Cl&H0&+0&D1:1]-N1-C(=O)-C-C-C-1=O>>[C&H2&+0&D2:3](-[C:2])-[Cl&H0&+0&D1:1]|[CH3:1][CH2:2][O:3][C:4]([CH3:5])([O:6][CH2:7][CH3:8])[O:9][CH2:10][CH3:11].O=C1CCC(N1[Cl:12])=O>ClC(Cl)(Cl)Cl>[CH3:1][CH2:2][O:3][C:4]([CH2:5][Cl:12])([O:6][CH2:7][CH3:8])[O:9][CH2:10][CH3:11]|US20200101068A1_0764
10.1.2|[C&H3&+0&D1:3]-[c:2].[Cl&H0&+0&D1:1]-N1-C(=O)-C-C-C-1=O>>[C&H2&+0&D2:3](-[Cl&H0&+0&D1:1])-[c:2]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]([n:8][cH:9][cH:10][c:11]21)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18].O=C1CCC(N1[Cl:19])=O>ClC(Cl)(Cl)Cl>[Cl:18][c:15]1[cH:14][cH:13][c:12]([cH:17][cH:16]1)-[c:7]1[n:8][cH:9][cH:10][c:11]2[c:6]1[cH:5][cH:4][cH:3][c:2]2[CH2:1][Cl:19]|US20080103141A1_0758
7.6.1|[C&H3&D1:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[C:1]|[CH3:1][CH:2]=[CH:3][CH:4]([OH:5])[CH:6]([O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[C:15](=[O:16])[N:17]1[C:18]([O:19][CH2:20][C@@H:21]1[CH:22]([CH3:23])[CH3:24])=[Se:25]>>[CH3:1][CH2:2][CH2:3][CH:4]([OH:5])[CH:6]([O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[C:15](=[O:16])[N:17]1[C:18]([O:19][CH2:20][C@@H:21]1[CH:22]([CH3:23])[CH3:24])=[Se:25]|US20120202287A1_0427
6.5.10|[C:4]-[C&H0&+0&D4:3](-[c:2])(-[O&H0&+0&D2:1]-C)-O-C>>[C:4]-[C&H0&+0&D3:3](-[c:2])=[O&H0&+0&D1:1]|C[O:1][C:2](OC)([C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O.Cc1ccc(cc1)S(=O)(=O)O.OCCOCCOCCO>[O:4]=[C:3]([C:2](=[O:1])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1|US20090048258A1_1446
9.7.10|[I&H0&+0&D1:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-N>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|N[c:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)-[c:7]1[cH:8][cH:9][cH:10][n:11][cH:12]1.[I:13][Na]>O.O.O.[Na+].CC(=O)O.CC([O-])=O.O=NO[Na].O=C(O)C(F)(F)F>[I:13][c:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)-[c:7]1[cH:12][n:11][cH:10][cH:9][cH:8]1|US09113629B2_0315
9.7.10|[I&H0&+0&D1:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[n:1])-N>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|N[c:1]1[n:2][cH:3][cH:4][cH:5][c:6]1[N+:7]([O-:8])=[O:9].[I:10][K]>O.[Na+].Cl.O=NO[Na].[OH-]>[O-:8][N+:7](=[O:9])[c:6]1[cH:5][cH:4][cH:3][n:2][c:1]1[I:10]|US20200048242A1_0357
7.9.8|[C&H3&D1:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[C:1]>>[C&H3&D1:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]|[CH3:1][C:2]#[C:3][CH:4]([c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[n:11][n:12][n:13]2[CH3:14])[n:15]1[cH:16][cH:17][n:18][cH:19]1>CCO.CCOC(C)=O.c1ccc2ccccc2n1.[H][H].[Pd]>[CH3:1][CH:2]=[CH:3][CH:4]([c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[n:11][n:12][n:13]2[CH3:14])[n:15]1[cH:16][cH:17][n:18][cH:19]1|US09284513B2_0040
7.6.1|[C&H3&D1:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][CH:2]=[CH:3][c:4]1[cH:5][cH:6][c:7]2[O:8][CH:9]([O:10][CH2:11][c:12]2[cH:13]1)[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>CCO.[H][H].[Pd]>[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]2[O:8][CH:9]([O:10][CH2:11][c:12]2[cH:13]1)[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]|EP2079466B1_0149
9.7.10|[I&H0&+0&D1:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[c:1])-N>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[C:13]([F:14])([F:15])[F:16])N.[I:17][K]>O=S(=O)(O)O.CC(=O)O.O=NO[Na].O>[CH3:1][CH:2]([CH3:3])[C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[C:13]([F:14])([F:15])[F:16])[I:17]|US03981932A
9.7.73|[N&+:4]=[N&H0&+0&D2:3]-[#11].[c:2]-[C&H2&+0&D2:1]-O>>[N&+:4]=[N&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][n:8]1)[CH2:9]O.[N-:10]=[N+:11]=[N:12][Na]>CCCC[N+](CCCC)(CCCC)CCCC.O=C(OC(=O)C(F)(F)F)C(F)(F)F.Cc1ccccc1.CCN(CC)CC.CS(C)=O.ClCCl.[Br-]>[N-:10]=[N+:11]=[N:12][CH2:9][c:6]1[cH:7][n:8][c:3]([cH:4][cH:5]1)[C:2]#[N:1]|US20130005721A1_0445
7.3.4|[C&H3&D1:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][N:2]=[CH:3][c:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)[CH2:18][OH:19]>[Na+].CC(C)O.[BH4-]>[CH3:1][NH:2][CH2:3][c:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)[CH2:18][OH:19]|US10781178B2_1051
7.3.4|[O&H1&D1:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[O&H1&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[OH:1][N:2]=[CH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[Cl:10]>[Na+].Cl.CO.CN(C)c1ccc(cc1)N=Nc1ccc(cc1)S(=O)(=O)O.N#C[BH3-].[BH4-]>[OH:1][NH:2][CH2:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[Cl:10]|US07745663B2_0966
3.5.2|[C:4]-[C&H2&+0&D2:3]-[#12]-Br.[c:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH2:1]=[CH:2][CH2:3][Mg]Br.Br[CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[Br:11]>O.C1CCOC1>[CH2:1]=[CH:2][CH2:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[Br:11]|US20200375949A1_0330
9.7.10|[I&H0&+0&D1:4]-[#19].[n:3]:[c&H0&+0&D3:2](:[n:1])-N>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][n:13]2[n:14][c:15]([n:16][c:17]12)N.[I:18][K]>O.Cc1ccc(cc1)S(=O)(=O)O.CC#N.CCOC(C)=O.O=NO[Na]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][n:13]2[n:14][c:15]([n:16][c:17]12)[I:18]|US20190202822A1_0285
9.7.10|[I&H0&+0&D1:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[n:1])-N>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|N[c:1]1[n:2][nH:3][c:4]2[n:5][cH:6][c:7]([cH:8][c:9]21)[F:10].[I:11][Na]>O.O.CCOCC.CC(C)=O.CC(C)CCON=O.C1CCOC1>[F:10][c:7]1[cH:6][n:5][c:4]2[nH:3][n:2][c:1]([c:9]2[cH:8]1)[I:11]|US10028942B2_0584
6.5.10|[C:4]-[C&H0&+0&D4:3](-[C:2])(-[O&H0&+0&D2:1]-C)-O-C>>[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]|C[O:1][C:2]1([CH2:3][CH2:4][C:5]([CH2:6][CH2:7]1)([OH:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[F:15])OC>c1ccccc1.CN(C)C=O.CI.[NaH]>[O:1]=[C:2]1[CH2:3][CH2:4][C:5]([CH2:6][CH2:7]1)([OH:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[F:15]|EP3169666B1_0155
3.5.2|[C:4]-[C&H2&+0&D2:3]-[#12]-Br.[C:2]-[C&H2&+0&D2:1]-Br>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]Br.[CH3:19][CH2:20][CH2:21][CH2:22][CH2:23][Mg]Br>C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:23][CH2:22][CH2:21][CH2:20][CH3:19]|EP0267439A2_0032
7.7.1|[C&H3&D1:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[c:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH3:1][C:2]#[C:3][c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[cH:13]1)-[c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[F:20])[F:21]>CCOC(C)=O.[H][H].[C].[Pd]>[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[cH:13]1)-[c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[F:20])[F:21]|EP1572686B1_0083
3.5.2|[C:4]-[C&H2&+0&D2:3]-Br.[C:2]-[C&H2&+0&D2:1]-[#12]-Cl>>[C:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH:2]([CH2:3][Cl:4])[CH2:5]Br.[CH3:6][CH2:7][CH2:8][Mg]Cl>>[CH3:6][CH2:7][CH2:8][CH2:5][CH:2]([CH3:1])[CH2:3][Cl:4]|US20190322614A1_0190
9.7.73|[C:4]-[C&H2&+0&D2:3]-O.[N&+:2]=[N&H0&+0&D2:1]-[#11]>>[C:4]-[C&H2&+0&D2:3]-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][CH2:2][N:3]([CH2:4][CH2:5]O)[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1.[N-:12]=[N+:13]=[N:14][Na]>O=S(=O)(O)O.[Na]>[CH3:1][CH2:2][N:3]([CH2:4][CH2:5][N:14]=[N+:13]=[N-:12])[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1|US09751886B2_0149
6.5.10|[c:4]-[C&H0&+0&D4:3](-[c:2])(-[O&H0&+0&D2:1]-C)-O-C>>[c:4]-[C&H0&+0&D3:3](-[c:2])=[O&H0&+0&D1:1]|[CH3:1][S:2][C:3]([CH3:4])([C:5](=[O:6])[O:7][CH3:8])[c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[C:15](OC)([O:16]C)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O.Cl.COCCOC.ClCCl>[CH3:1][S:2][C:3]([CH3:4])([C:5](=[O:6])[O:7][CH3:8])[c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[C:15](=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US07153958B2_0193
7.3.4|[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[O&H1&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[O&H1&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[n:9]1[n:10][c:11]([cH:12][c:13]1-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20])[CH2:21][CH2:22][CH:23]=[N:24][OH:25]>[Na+].Cl.CO.CN(C)c1ccc(cc1)N=Nc1ccc(cc1)S(=O)(=O)O.N#C[BH3-]>[CH3:1][O:2][c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)-[n:9]1[n:10][c:11]([cH:12][c:13]1-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20])[CH2:21][CH2:22][CH2:23][NH:24][OH:25]|EP1399416B1_0040
6.1.4|[C:4]-[C&H1&+0&D3:3](-[C:2])-[N&H1&+0&D2:1]-C(-C)=O>>[C:4]-[C@&H1&+0&D3:3](-[C:2])-[N&H2&+0&D1:1]|[CH3:1][S:2][CH2:3][CH2:4][CH:5]([NH:6]C(C)=O)[C:7](=[O:8])[OH:9]>CSCC[C@H](NC(C)=O)C(=O)O.Cl[Co]Cl.O[Na].O.O.O.O.O.O.O>[CH3:1][S:2][CH2:3][CH2:4][C@H:5]([NH2:6])[C:7](=[O:8])[OH:9]|EP0013044A1_0042
9.1.5|[Br&H0&+0&D1:4]-[#3].[C:3]-[C&H1&+0&D3:2](-[C:1])-O>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][CH:14]([CH2:15][CH2:16]1)O.[Br:17][Li]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)N=NC(=O)OCC.C1CCOC1>[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][CH:14]([CH2:15][CH2:16]1)[Br:17]|US20050245764A1_0207
1.7.3|[C&H3&D1:4]-[C&H2&+0&D2:3]-I.[C:2]-[O&H0&-&D1:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[Na+].[CH3:1][CH2:2]I.[NH2:3][c:4]1[c:5]([cH:6][cH:7][cH:8][c:9]1[C:10](=[O:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18])[CH2:19][C:20]([O-:21])=[O:22]>O.CN(C)C=O>[CH3:1][CH2:2][O:21][C:20](=[O:22])[CH2:19][c:5]1[cH:6][cH:7][cH:8][c:9]([c:4]1[NH2:3])[C:10](=[O:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18]|EP0127848A2_0070
1.7.9|[C&H3&D1:4]-[O&H0&-&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[Na+].[CH3:1][O-:2].Cl[CH2:3][CH2:4][CH2:5][CH2:6][O:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21>O.CO>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]12|EP2914574B1_0120
1.8.13|[C&H3&D1:4]-[S&H0&-&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[Na+].Cl.[CH3:1][n:2]1[cH:3][c:4]([c:5]([c:6]2[cH:7][cH:8][c:9]([cH:10][c:11]21)[C:12]([F:13])([F:14])[F:15])=[O:16])[CH2:17]Cl.[CH3:18][S-:19]>O.CO>[CH3:1][n:2]1[cH:3][c:4]([c:5]([c:6]2[cH:7][cH:8][c:9]([cH:10][c:11]21)[C:12]([F:13])([F:14])[F:15])=[O:16])[CH2:17][S:19][CH3:18]|US05206240A
1.2.2|[C&H3&D1:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[N:1]>>[C&H3&D1:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[N:1]|[CH3:1][CH:2]=O.[NH2:3][NH:4][c:5]1[cH:6][cH:7][c:8]2[O:9][CH2:10][CH2:11][O:12][c:13]2[cH:14]1>CCOCC>[CH3:1][CH:2]=[N:3][NH:4][c:5]1[cH:6][cH:7][c:8]2[O:9][CH2:10][CH2:11][O:12][c:13]2[cH:14]1|US09725426B2_0410
1.2.1|[C&H3&D1:4]-[N&H2&+0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[CH2:10][N:11]([CH2:12][c:13]2[s:14][c:15]([cH:16][c:17]21)[CH:18]=O)[CH3:19].[CH3:20][NH2:21]>C1CCOC1.[Ni]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[CH2:10][N:11]([CH2:12][c:13]2[s:14][c:15]([cH:16][c:17]21)[CH2:18][NH:21][CH3:20])[CH3:19]|EP3498707A1_0165
2.6.3|[C&H3&D1:4]-[C&H2&+0&D2:3]-O.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH2:2]O.[O:3]=[C:4]([OH:5])[CH2:6][c:7]1[c:8]([n:9][n:10]([c:11]1[Cl:12])-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25]>O.O=S(=O)(O)O>[CH3:1][CH2:2][O:5][C:4](=[O:3])[CH2:6][c:7]1[c:8]([n:9][n:10]([c:11]1[Cl:12])-[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25]|US06395748B2
1.7.9|[C&H3&D1:4]-[O&H0&-&D1:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[Na+].[CH3:1][O-:2].[O:3]=[C:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]Br)[N:10]1[CH2:11][CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21>O.CO>[CH3:1][O:2][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][C:4](=[O:3])[N:10]1[CH2:11][CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21|EP1572612B1_0099
3.9.54|[C:4]-[C&H0&+0&D3:3](-[C:2])=O.[C&H2&+0&D2:1](-Br)-Br>>[C:4]-[C&H0&+0&D3:3](-[C:2])=[C&H2&+0&D1:1]|O=[C:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1.Br[CH2:14]Br>O=CC1CCCCCCCCCCCC1.Cl[Ti](Cl)(Cl)Cl.C1CCOC1.[Zn]>[CH2:14]=[C:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1|US20070244155A1_0521
1.2.1|[C&H3&D1:4]-[N&H2&+0&D1:3].[C:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH:11]=[CH:12][CH:13]=O.[CH3:14][NH2:15]>c1ccccc1.[O-]S([O-])(=O)=O.[Mg+2]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH:11]=[CH:12][CH2:13][NH:15][CH3:14]|US20200039951A1_0415
1.8.12|[C&H3&D1:4]-[S&H0&-&D1:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[Na+].[CH3:1][C:2]1([O:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[O:10]1)[C:11](=[O:12])[CH2:13]Br)[CH3:14].[CH3:15][S-:16]>CCC(=S)c1ccccc1.CO>[CH3:1][C:2]1([O:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[O:10]1)[C:11](=[O:12])[CH2:13][S:16][CH3:15])[CH3:14]|US20150158851A1_0366
1.8.13|[C&H3&D1:4]-[S&H0&-&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[Na+].[CH3:1][S-:2].[O:3]=[C:4]([CH2:5]Cl)[c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[OH:12])[OH:13]>CO.CCC(=S)c1ccccc1>[CH3:1][S:2][CH2:5][C:4](=[O:3])[c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[OH:12])[OH:13]|US20100298343A1_0720
9.7.141|[C:4]-[C&H0&+0&D4:3](-[F&H0&D1:2])(-[F&H0&D1:1])-I>>[C:4]-[C&H1&+0&D3:3](-[F&H0&D1:2])-[F&H0&D1:1]|[F:1][C:2]([F:3])([F:4])[C:5]([F:6])([F:7])[C:8]([F:9])([F:10])[C:11]([F:12])([F:13])I>FC(F)(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)F.CO>[F:1][C:2]([F:3])([F:4])[C:5]([F:6])([F:7])[C:8]([F:9])([F:10])[CH:11]([F:12])[F:13]|US06703533B1
9.7.140|[F&H0&D1:4]-[C&H0&+0&D4:3](-[F&H0&D1:2])(-[c:1])-F>>[F&H0&D1:4]-[C&H1&+0&D3:3](-[F&H0&D1:2])-[c:1]|[F:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[CH2:8][N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[c:15]1[cH:16][cH:17][c:18]2[n:19][n:20][c:21]([n:22]2[n:23]1)[C:24]([F:25])([F:26])F)[CH:27]([F:28])[F:29]>FC(F)c1nnc2ccc(nn12)N1CCNCC1>[F:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[CH2:8][N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[c:15]1[cH:16][cH:17][c:18]2[n:19][n:20][c:21]([n:22]2[n:23]1)[CH:24]([F:25])[F:26])[CH:27]([F:28])[F:29]|US09540343B2_1287
1.7.9|[C:4]-[C&H2&+0&D2:3]-O-S(-C)(=O)=O.[C:2]-[O&H1&+0&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|CS(=O)(=O)O[CH2:1][CH2:2][NH:3][C:4](=[O:5])[CH:6]([OH:7])[CH:8]([O:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[N+:16]([O-:17])=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>O.CN(C)C=O.O=C(O[K])O[K]>[O-:17][N+:16](=[O:18])[c:15]1[cH:14][cH:13][cH:12][cH:11][c:10]1[O:9][CH:8]([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[CH:6]1[O:7][CH2:1][CH2:2][NH:3][C:4]1=[O:5]|US20200148705A1_1859
9.7.92|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C:4]/[C&H1&+0&D2:3]=[N&H0&+0&D2:2]\[O&H1&D1:1]|Cl.[NH2:1][OH:2].O=[CH:3][CH2:4][P:5](=[O:6])([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>O.Cl.CCO.O[Na]>[O:6]=[P:5]([CH2:4]/[CH:3]=[N:1]\[OH:2])([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US10538512B2_0575
1.7.9|[C&H3&D1:4]-[O&H0&-&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[Na+].[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([c:10]1[Cl:11])[CH2:12]Br)[S:13]([CH3:14])(=[O:15])=[O:16].[CH3:17][O-:18]>CO>[CH3:17][O:18][CH2:12][c:9]1[c:10]([c:5]([cH:6][cH:7][c:8]1[S:13]([CH3:14])(=[O:15])=[O:16])[C:3](=[O:4])[O:2][CH3:1])[Cl:11]|EP3215482B1_0041
9.7.92|[C:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[O&H1&D1:1]|Cl.[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5][CH2:6][CH:7]([CH3:8])[CH2:9][CH:10]=O.[NH2:11][OH:12]>O.O=C(O[Na])O[Na]>[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5][CH2:6][CH:7]([CH3:8])[CH2:9][CH:10]=[N:11][OH:12]|US20190127358A1_1390
1.6.8|[C&H3&D1:4]-[C&H2&+0&D2:3]-I.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[NH2:13].[CH3:14][CH2:15]I>CC(C)O.c1ccncc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:12][cH:11][c:10]([cH:9][cH:8]1)[NH:13][CH2:15][CH3:14]|US20180072997A1_0429
9.7.12|[C:4]-[N&H2&+0&D1:3].[S&H0&D1:2]=[C&H0&+0&D2:1]=S>>[C:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:1]=[S&H0&D1:2]|[NH2:1][CH:2]1[CH2:3][CH2:4][CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21.[S:12]=[C:13]=S>C(=NC1CCCCC1)=NC1CCCCC1.CCN(CC)CC.CCOC(C)=O>[S:12]=[C:13]=[N:1][CH:2]1[CH2:3][CH2:4][CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21|US20190345191A1_0585
1.2.9|[C&H3&D1:4]-[N&H2&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-O>>[C&H3&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|O[CH2:1][c:2]1[cH:3][c:4]2[cH:5][cH:6][cH:7][c:8]3[c:9]4=[N:10][NH:11][CH2:12][n:13]4[c:14]4[cH:15][cH:16][c:17]([cH:18][c:19]4[n:20]1[c:21]32)[Br:22].[CH3:23][NH2:24]>CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>[CH3:23][NH:24][CH2:1][c:2]1[cH:3][c:4]2[cH:5][cH:6][cH:7][c:8]3[c:9]4=[N:10][NH:11][CH2:12][n:13]4[c:14]4[cH:15][cH:16][c:17]([cH:18][c:19]4[n:20]1[c:21]32)[Br:22]|US20200172539A1_0761
1.2.2|[C&H3&D1:4]-[N&H2&+0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:4]/[N&H0&+0&D2:3]=[C&H1&+0&D2:1]/[c:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[Br:9])-[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH:16]=O.[CH3:17][NH2:18]>CCO.O=S1(O[Mg]O1)=O.ClCCl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[Br:9])-[c:10]1[cH:15][cH:14][c:13]([cH:12][cH:11]1)/[CH:16]=[N:18]/[CH3:17]|US20070172421A1_0208
9.7.60|[C&H3&D1:4]-[C&H0&+0&D4:3](-[C&H3&D1:2])(-[c:1])-O>>[C&H3&D1:4]-[C&H1&+0&D3:3](-[C&H3&D1:2])-[c:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[C:10]([CH3:11])([CH3:12])O.[O-]O>>[CH3:11][CH:10]([CH3:12])[c:8]1[cH:7][cH:6][cH:5][c:4]([cH:9]1)[CH:2]([CH3:1])[CH3:3]|US04337256A
1.7.9|[C&H3&D1:4]-[C&H2&+0&D2:3]-I.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][n:3]1[n:4][cH:5][c:6]2[n:7][c:8]([c:9]([n:10][c:11]21)[OH:12])[C:13]#[N:14].[CH3:15][CH2:16]I>CCO.[Na]>[CH3:15][CH2:16][O:12][c:9]1[n:10][c:11]2[c:6]([cH:5][n:4][n:3]2[CH2:2][CH3:1])[n:7][c:8]1[C:13]#[N:14]|EP3191449B1_0184
1.2.1|[C&H3&D1:4]-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[NH2:12])[C:13]([F:14])([F:15])[F:16].[CH3:17][CH:18]=O>CCO.[Pd]>[CH3:17][CH2:18][NH:12][c:10]1[cH:11][c:6]([cH:7][cH:8][c:9]1[C:13]([F:14])([F:15])[F:16])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20200262844A1_0340
1.7.7|[C&H3&D1:4]-[C&H2&+0&D2:3]-O.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2]O.[OH:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)-[c:10]1[cH:11][n:12]2[cH:13][cH:14][c:15]3[cH:16][cH:17][cH:18][cH:19][c:20]3[c:21]2[n:22]1>CCOS(=O)(=O)OCC.O[K]>[CH3:1][CH2:2][O:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)-[c:10]1[cH:11][n:12]2[cH:13][cH:14][c:15]3[cH:16][cH:17][cH:18][cH:19][c:20]3[c:21]2[n:22]1|US20070275962A1_1242
2.1.18|[C:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H1&+0&D2:1]-O>>[C:4]-[N&H1&+0&D2:3]-[C&H1&+0&D2:1]=[O&H0&D1:2]|[CH3:1][C:2]([CH3:3])([NH2:4])[C:5](=[O:6])[OH:7].[O:8]=[CH:9]O>O.Cl.CC(C)C(=O)N(CC)C(N)C(=O)O.CC(=O)OC(C)=O>[CH3:1][C:2]([CH3:3])([NH:4][CH:9]=[O:8])[C:5](=[O:6])[OH:7]|US05719141A
1.7.9|[C&H3&D1:4]-[C&H2&+0&D2:3]-I.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH:2]([CH2:3][OH:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[cH:16][cH:17][c:18]2[cH:19]1)=[O:20].[CH3:21][CH2:22]I>O.CCOCC.CN(C)C=O.[H][H].[NaH]>[CH3:21][CH2:22][O:4][CH2:3][CH:2]([CH3:1])[c:5]1[cH:6][cH:7][c:8]2[c:9]([c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[cH:16][cH:17][c:18]2[cH:19]1)=[O:20]|EP2692361A1_0037
1.7.9|[C&H3&D1:4]-[O&H0&-&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[Na+].Cl.[CH3:1][O-:2].Cl[CH2:3][c:4]1[cH:5][cH:6][cH:7][cH:8][n:9]1>CO>[CH3:1][O:2][CH2:3][c:4]1[cH:5][cH:6][cH:7][cH:8][n:9]1|US20110263647A1_0435
1.2.2|[C&H3&D1:4]-[N&H2&+0&D1:3].[C:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:1]-[C:2]|O=[CH:1][CH:2]1[CH2:3][CH2:4][S:5][c:6]2[c:7]1[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[n:14]2-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[CH3:21][NH2:22]>c1ccccc1.CO>[CH3:21][N:22]=[CH:1][CH:2]1[CH2:3][CH2:4][S:5][c:6]2[c:7]1[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[n:14]2-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20070172421A1_0158
9.7.140|[C:4]-[C&H0&+0&D4:3](-[F&H0&D1:2])(-[F&H0&D1:1])-F>>[C:4]-[C&H1&+0&D3:3](-[F&H0&D1:2])-[F&H0&D1:1]|[CH3:1][CH:2]([NH2:3])[c:4]1[cH:5][cH:6][c:7]([n:8][cH:9]1)[O:10][CH2:11][C:12]([F:13])([F:14])F>N#Cc1ccc(nc1)Cl.OCC(F)(F)C(F)F>[CH3:1][CH:2]([NH2:3])[c:4]1[cH:5][cH:6][c:7]([n:8][cH:9]1)[O:10][CH2:11][CH:12]([F:13])[F:14]|US20040167160A1_0144
1.2.2|[C&H3&D1:4]-[N&H2&+0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:4]-[N&H0&+0&D2:3]=[C&H1&+0&D2:1]-[c:2]|[CH3:1][NH2:2].O=[CH:3][c:4]1[cH:5][n:6][c:7]([cH:8][cH:9]1)[Cl:10]>[Na+].[Na+].Cc1ccccc1.[O-]S([O-])(=O)=O.O=S1(O[Mg]O1)=O>[CH3:1][N:2]=[CH:3][c:4]1[cH:9][cH:8][c:7]([n:6][cH:5]1)[Cl:10]|US20110251173A1_0583
1.2.9|[C&H3&D1:4]-[N&H2&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-O>>[C&H3&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|O[CH2:1][CH2:2][N:3]1[CH2:4][CH2:5][n:6]2[c:7]1[n:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]12.CCO.[CH3:15][NH2:16]>CCN(CC)CC.CS(=O)(=O)Cl.ClCCl>[CH3:15][NH:16][CH2:1][CH2:2][N:3]1[CH2:4][CH2:5][n:6]2[c:14]3[cH:13][cH:12][cH:11][cH:10][c:9]3[n:8][c:7]12|US20200291027A1_1339
1.6.8|[C&H3&D1:4]-[N&H2&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-I>>[C&H3&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[ClH:1].[CH3:2][NH2:3].[O-:4][N+:5](=[O:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[O:13][CH2:14][CH2:15][CH2:16]I>CCO>[ClH:1].[CH3:2][NH:3][CH2:16][CH2:15][CH2:14][O:13][c:10]1[cH:9][cH:8][c:7]([cH:12][cH:11]1)[N+:5]([O-:4])=[O:6]|US20130252890A1_0540
1.8.12|[C&H3&D1:4]-[S&H0&-&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][S-:2].Br[CH2:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[Br:10].[Li+]>[NH4+].[Cl-].CCO.C1CCOC1>[CH3:1][S:2][CH2:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[Br:10]|US20170114025A1_0828
1.2.9|[C&H3&D1:4]-[C&H2&+0&D2:3]-O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2]O.[CH3:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[OH:10])[NH2:11]>O.CCBr.O=C(O[Na])O[Na]>[CH3:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[OH:10])[NH:11][CH2:2][CH3:1]|EP3016951B1_0467
1.6.8|[C&H3&D1:4]-[C&H2&+0&D2:3]-I.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:1]-[C:2]|[CH3:1][CH2:2]I.[NH2:3][CH2:4][CH2:5][N:6]([CH2:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[c:16]1[cH:17][c:18]([cH:19][cH:20][c:21]1[Cl:22])[Cl:23]>CCN(CC)CCNc1cc(ccc1Cl)Cl.O=C(CCl)c1ccccc1>[CH3:1][CH2:2][NH:3][CH2:4][CH2:5][N:6]([CH2:7][C:8](=[O:9])[c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1)[c:16]1[cH:17][c:18]([cH:19][cH:20][c:21]1[Cl:22])[Cl:23]|EP1539724B1_0126
1.2.1|[C&H3&D1:4]-[C&H1&+0&D2:3]=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:1]-[C:2]|[CH3:1][NH:2][C@@H:3]1[C@H:4]([C@H:5]([O:6][CH2:7][C@:8]1([CH3:9])[OH:10])[O:11][C@@H:12]1[C@H:13]([C@@H:14]([C@H:15]([CH2:16][C@H:17]1[NH2:18])[NH2:19])[O:20][C@H:21]1[O:22][C:23](=[CH:24][CH2:25][C@H:26]1[NH2:27])[CH2:28][NH2:29])[OH:30])[OH:31].[CH3:32][CH:33]=O>Cc1ccc(cc1)S(=O)(=O)O.O=C(O)C(F)(F)F.O=S(=O)(O)O.O=P(O)(O)O.CC(=O)O.[O-][N+](=O)O.N#C[BH3-].O.[Na+].Cl>[CH3:32][CH2:33][NH:18][C@@H:17]1[CH2:16][C@@H:15]([C@H:14]([C@@H:13]([C@H:12]1[O:11][C@H:5]1[O:6][CH2:7][C@:8]([C@@H:3]([C@H:4]1[OH:31])[NH:2][CH3:1])([CH3:9])[OH:10])[OH:30])[O:20][C@H:21]1[O:22][C:23](=[CH:24][CH2:25][C@H:26]1[NH2:27])[CH2:28][NH2:29])[NH2:19]|US20200017525A1_0833
1.8.15|[C&H3&D1:4]-[C&H2&+0&D2:3]-I.[S&H1&+0&D1:2]-[c:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2]I.[NH2:3][S:4](=[O:5])(=[O:6])[c:7]1[cH:8][c:9]([cH:10][c:11]([c:12]1[CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[SH:20])[C:21](=[O:22])[OH:23]>[Na+].[Na+].[Na+].[O-]C(=O)O.[O-]S(=O)S([O-])=O>[CH3:1][CH2:2][S:20][c:11]1[cH:10][c:9]([cH:8][c:7]([c:12]1[CH2:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)[S:4]([NH2:3])(=[O:5])=[O:6])[C:21](=[O:22])[OH:23]|US20200216410A1_0372
9.7.139|[C:4]-[C&H0&+0&D4:3](-[F&H0&D1:2])(-[F&H0&D1:1])-Br>>[C:4]-[C&H1&+0&D3:3](-[F&H0&D1:2])-[F&H0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][CH2:8][C:9]([F:10])([F:11])[C:12]([F:13])([F:14])Br>[Na+].CO.C1CCOC1.[BH4-]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][CH2:8][C:9]([F:10])([F:11])[CH:12]([F:13])[F:14]|EP3670501A1_0354
9.7.59|[F&H0&D1:4]-[C&H0&+0&D4:3](-[F&H0&D1:2])(-[c:1])-Cl>>[F&H0&D1:4]-[C&H1&+0&D3:3](-[F&H0&D1:2])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([c:7]([c:8]([n:9][c:10]1[C:11]([F:12])([F:13])Cl)[C:14]([F:15])([F:16])[F:17])[C:18](=[O:19])[O:20][CH2:21][CH3:22])[O:23][CH:24]([CH3:25])[CH3:26]>CCN(CC)CC.CCO.[H][H].[Pd]>[CH3:22][CH2:21][O:20][C:18](=[O:19])[c:7]1[c:6]([c:5]([c:10]([n:9][c:8]1[C:14]([F:15])([F:16])[F:17])[CH:11]([F:12])[F:13])[C:3](=[O:4])[O:2][CH3:1])[O:23][CH:24]([CH3:25])[CH3:26]|EP3097081B1_0021
1.2.1|[C:5]-[N&H2&+&D2:4]-[C:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C@@H:2]1[CH2:3][CH2:4][C@H:5]([CH2:6][CH2:7]1)[N:8]([C:9](=[O:10])[NH:11][c:12]1[n:13][cH:14][c:15]([s:16]1)[CH:17]=O)[CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1.[CH3:24][O:25][C:26](=[O:27])[CH2:28][CH2:29][S:30](=[O:31])(=[O:32])[N:33]1[CH2:34][CH2:35][NH2+:36][CH2:37][CH2:38]1>[Cl-]>[CH3:24][O:25][C:26](=[O:27])[CH2:28][CH2:29][S:30](=[O:31])(=[O:32])[N:33]1[CH2:34][CH2:35][N:36]([CH2:37][CH2:38]1)[CH2:17][c:15]1[cH:14][n:13][c:12]([s:16]1)[NH:11][C:9](=[O:10])[N:8]([CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1)[C@H:5]1[CH2:4][CH2:3][C@@H:2]([CH2:7][CH2:6]1)[CH3:1]|US20130040978A1_0969
9.7.43|[C:4]-[C&H2&+0&D2:3]-Cl.[N&H2&+0&D1:2]-[N&H2&D1:1]>>[C:4]-[C&H2&+0&D2:3]-[N&H1&+0&D2:2]-[N&H2&D1:1]|O.Cl.[NH2:1][NH2:2].Cl[CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1>O.O=C(O[K])O[K].O[Na]>[NH2:1][NH:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1|US20100094000A1_0930
3.5.3|[C&H3&+0&D1:4]-[#30&+].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[c:2]1[cH:3][c:4]([n:5]([c:6]2[c:7]1[cH:8][c:9]([c:10]([n:11]2)Cl)[F:12])-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[NH:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[CH3:26][Zn+].[Cl-]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O.C1CCOC1.O>[CH3:26][c:10]1[n:11][c:6]2[c:7]([cH:8][c:9]1[F:12])[c:2]([cH:3][c:4]([n:5]2-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[NH:19][c:20]1[cH:25][cH:24][cH:23][cH:22][cH:21]1)=[O:1]|EP2681194B1_0812
1.7.9|[F&H0&D1:4]-[C&H2&+0&D2:3]-Br.[O&H1&+0&D1:2]-[c:1]>>[F&H0&D1:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][C@@H:10]([CH2:11][O:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[O:19][Si:20]([CH2:21][CH3:22])([CH2:23][CH3:24])[CH2:25][CH3:26])[CH:27]1[CH2:28][CH2:29][CH2:30][c:31]2[cH:32][cH:33][c:34]([cH:35][c:36]2[CH2:37]1)[OH:38].[F:39][CH2:40]Br>O=C(O[K])O[K].CN(C)C=O.O=C(O)O[Na].CC#N>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][C@@H:10]([CH2:11][O:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[O:19][Si:20]([CH2:21][CH3:22])([CH2:23][CH3:24])[CH2:25][CH3:26])[CH:27]1[CH2:28][CH2:29][CH2:30][c:31]2[cH:32][cH:33][c:34]([cH:35][c:36]2[CH2:37]1)[O:38][CH2:40][F:39]|EP1460062A1_0329
10.1.1|[Br&H0&-&D0:4].[C&H3&D1:3]-[C&H2&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[C:1]|[CH3:1][CH2:2][O:3][CH:4]([CH2:5][CH3:6])[O:7][CH2:8][CH3:9].[Br-:10]>ClC(Cl)(Cl)Cl>[CH3:1][CH2:2][O:3][CH:4]([O:7][CH2:8][CH3:9])[CH:5]([CH3:6])[Br:10]|US20170050980A1_0808
1.6.4|[C&H3&D1:4]-[N&H2&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][NH2:2].Cl[CH2:3][c:4]1[n:5][n:6][c:7]2[CH2:8][N:9]=[C:10]([c:11]3[cH:12][c:13]([cH:14][cH:15][c:16]3-[n:17]12)[Cl:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>I[Na]>[CH3:1][NH:2][CH2:3][c:4]1[n:5][n:6][c:7]2[CH2:8][N:9]=[C:10]([c:11]3[cH:12][c:13]([cH:14][cH:15][c:16]3-[n:17]21)[Cl:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|US20190194179A1_0520
3.9.24|[C&H3&+0&D1:4]-[#12&+].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[n:6][c:7]([cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14])Cl.[CH3:15][Mg+].[Br-]>Cl[Ni]1([P](CCC[P]1(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1)Cl.CCOCC.C1CCOC1>[CH3:14][O:13][c:12]1[cH:11][c:10]2[n:9][cH:8][c:7]([n:6][c:5]2[cH:4][c:3]1[O:2][CH3:1])[CH3:15]|US20090143361A1_0522
1.6.2|[C:4]-[N&H2&+0&D1:3].[N&H0&D1:2]#[C&H0&+0&D2:1]-Br>>[C:4]-[N&H1&+0&D2:3]-[C&H0&+0&D2:1]#[N&H0&D1:2]|[CH3:1][CH2:2][O:3][CH:4]([CH2:5][NH2:6])[O:7][CH2:8][CH3:9].[N:10]#[C:11]Br>O.CCOCC>[CH3:1][CH2:2][O:3][CH:4]([CH2:5][NH:6][C:11]#[N:10])[O:7][CH2:8][CH3:9]|EP3431086B1_0365
3.9.60|[C&H3&+0&D1:4]-[#30&+].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[c:3]([cH:4][c:5]([c:6]([c:7]1[CH3:8])Br)[S:9]([CH3:10])(=[O:11])=[O:12])[C:13](=[O:14])[N:15]=[C:16]([NH2:17])[NH2:18].[CH3:19][Zn+].[Cl-]>CS(=O)(=O)c1cc(c(c(c1Br)C)C)C(=O)Cl.CCN(CC)CC.C1CCOC1.N=C(N)N.I[Cu].Cl>[CH3:8][c:7]1[c:2]([c:3]([cH:4][c:5]([c:6]1[CH3:19])[S:9]([CH3:10])(=[O:11])=[O:12])[C:13](=[O:14])[N:15]=[C:16]([NH2:17])[NH2:18])[CH3:1]|US20140323300A1_0128
1.7.9|[C&H3&D1:4]-[O&H1&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][OH:2].[O:3]=[C:4]([OH:5])[c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[CH2:12]Br>[Na+].C[O-]>[CH3:1][O:2][CH2:12][c:10]1[cH:9][cH:8][cH:7][c:6]([cH:11]1)[C:4](=[O:3])[OH:5]|EP3747862A1_0077
1.6.2|[C&H3&D1:4]-[N&H2&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9]Br)[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH3:16][NH2:17]>c1ccccc1>[CH3:16][NH:17][CH2:9][c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[C:2](=[O:1])[c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US20200345009A1_0128
1.8.12|[C&H3&D1:4]-[C&H2&+0&D2:3]-Br.[S&H1&+0&D1:2]-[c:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[ClH:1].[CH3:2][CH2:3]Br.[NH2:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[SH:11]>O.CCOC(C)=O.CN(C)C=O.[O-]C([O-])=O.[K+].[K+]>[ClH:1].[CH3:2][CH2:3][S:11][c:9]1[cH:10][c:5]([cH:6][cH:7][cH:8]1)[NH2:4]|US20120095048A1_0614
1.8.13|[C&H3&D1:4]-[S&H1&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][CH2:3][N:4]([CH2:5][CH2:6][CH2:7]Cl)[CH:8]1[CH2:9][CH2:10][c:11]2[c:12]([cH:13][cH:14][cH:15][c:16]2[CH2:17]1)[O:18][CH3:19].[CH3:20][SH:21]>CCO.[Na]>[CH3:19][O:18][c:12]1[cH:13][cH:14][cH:15][c:16]2[CH2:17][CH:8]([CH2:9][CH2:10][c:11]12)[N:4]([CH2:3][CH2:2][CH3:1])[CH2:5][CH2:6][CH2:7][S:21][CH3:20]|EP0527314A1_0017
1.7.9|[C&H3&D1:4]-[O&H1&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH2:1]=[C:2]([CH2:3]Cl)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[N+:10]([O-:11])=[O:12].[CH3:13][OH:14]>CO[Na]>[CH2:1]=[C:2]([CH2:3][O:14][CH3:13])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[N+:10]([O-:11])=[O:12]|US05767131A
1.6.2|[N&H0&D1:4]#[C&H0&+0&D2:3]-Br.[N&H2&+0&D1:2]-[c:1]>>[N&H0&D1:4]#[C&H0&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[NH2:10].[N:11]#[C:12]Br>CCOCC>[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[NH:10][C:12]#[N:11]|US20100152160A1_0859
1.7.9|[C&H3&D1:4]-[C&H2&+0&D2:3]-Br.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[OH:9])[CH:10]=[O:11].[CH3:12][CH2:13]Br>O.CCO.[OH-].[K+]>[CH3:12][CH2:13][O:9][c:8]1[cH:7][c:6]([cH:5][cH:4][c:3]1[O:2][CH3:1])[CH:10]=[O:11]|EP3523301B1_0749
1.7.9|[C&H3&D1:4]-[O&H1&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][OH:2].[O:3]=[C:4]([c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11]Cl)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>O[K]>[CH3:1][O:2][CH2:11][c:8]1[cH:7][cH:6][c:5]([cH:10][cH:9]1)[C:4](=[O:3])[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|EP3750891A1_0193
1.1.7|[C:5]-[C&H2&+0&D2:4]-I.[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+&D3:2](:[c:3]):[c:1]|[NH2:1][CH:2]1[C:3]([N:4]2[C:5](=[C:6]([CH2:7][S:8][C@H:9]12)[CH2:10]I)[C:11]([O-:12])=[O:13])=[O:14].[cH:15]1[cH:16][n:17]2[cH:18][cH:19][n:20][cH:21][c:22]2[cH:23]1>O.CC#N>[NH2:1][CH:2]1[C:3]([N:4]2[C:5](=[C:6]([CH2:7][S:8][C@H:9]12)[CH2:10][n+:20]1[cH:21][c:22]2[cH:23][cH:15][cH:16][n:17]2[cH:18][cH:19]1)[C:11]([O-:12])=[O:13])=[O:14]|US05593984A
1.7.9|[C&H3&D1:4]-[C&H2&+0&D2:3]-Br.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:1]-[C:2]|[CH2:1]=[C:2]([CH3:3])[C@@H:4]1[CH2:5][CH2:6][C@@H:7]([CH2:8][CH2:9]1)[CH2:10][OH:11].[CH3:12][CH2:13]Br>CS(C)=O.[NaH]>[CH2:1]=[C:2]([CH3:3])[C@@H:4]1[CH2:5][CH2:6][C@@H:7]([CH2:8][CH2:9]1)[CH2:10][O:11][CH2:13][CH3:12]|US20200113879A1_0487
1.8.12|[C&H3&D1:4]-[S&H1&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][SH:2].Br[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][c:17]1[cH:18][cH:19][c:20]2[O:21][CH2:22][O:23][c:24]2[cH:25]1>COCCOC.O[K]>[CH3:1][S:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][c:17]1[cH:18][cH:19][c:20]2[O:21][CH2:22][O:23][c:24]2[cH:25]1|EP0166155A1_0031
1.6.4|[C&H3&D1:4]-[N&H2&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][NH2:2].Cl[CH2:3][CH:4]1[S:5][CH2:6][CH2:7][CH2:8][CH2:9][S:10]1>O[Na]>[CH3:1][NH:2][CH2:3][CH:4]1[S:5][CH2:6][CH2:7][CH2:8][CH2:9][S:10]1|US20200207759A1_0512
1.6.2|[C&H3&D1:4]-[N&H2&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:4]-[N&H1&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][NH2:2].[O:3]=[C:4]([c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH2:12][CH2:13][CH2:14][CH2:15]Br)[c:16]1[c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[o:23][c:24]1-[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>>[CH3:1][NH:2][CH2:15][CH2:14][CH2:13][CH2:12][O:11][c:8]1[cH:7][cH:6][c:5]([cH:10][cH:9]1)[C:4](=[O:3])[c:16]1[c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[o:23][c:24]1-[c:25]1[cH:30][cH:29][cH:28][cH:27][cH:26]1|US20200147234A1_0229
1.7.9|[C&H3&D1:4]-[O&H1&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][OH:2].[O:3]=[C:4]([OH:5])[CH:6]1[C:7](=[CH:8][S:9][C@@H:10]2[CH:11]([C:12]([N:13]21)=[O:14])[NH:15][C:16](=[O:17])[CH2:18][c:19]1[cH:20][cH:21][cH:22][s:23]1)[CH2:24]Br>CCOC(C)=O.O=C(O)O[Na].ClC(Cl)Cl>[CH3:1][O:2][CH2:24][C:7]1=[CH:8][S:9][C@@H:10]2[CH:11]([C:12]([N:13]2[CH:6]1[C:4](=[O:3])[OH:5])=[O:14])[NH:15][C:16](=[O:17])[CH2:18][c:19]1[cH:20][cH:21][cH:22][s:23]1|US10590067B2_0293
7.6.1|[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[C&H2&+0&D2:2]-[c:1]|[CH3:1][CH2:2][N:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH:10]=[C:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)[C:18]#[N:19]>[Na+].CCO.[B-]>[CH3:1][CH2:2][N:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH2:10][CH:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)[C:18]#[N:19]|US20080280982A1_0125
9.7.157|[C&H0&-&D1:4]#[N&H0&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C&H0&+0&D2:4](#[N&H0&D1:3])-[C&H2&+0&D2:1]-[c:2]|[Na+].[C-:1]#[N:2].[F:3][C:4]([F:5])([F:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20]Cl>O.CCO>[N:2]#[C:1][CH2:20][c:17]1[cH:16][cH:15][c:14]([cH:19][cH:18]1)[CH2:13][c:10]1[cH:9][cH:8][c:7]([cH:12][cH:11]1)[C:4]([F:3])([F:5])[F:6]|US20190284182A1_0880
1.6.8|[C:5]-[C&H2&+0&D2:4]-I.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH2:1]=[CH:2][CH2:3]I.[O-:4][N+:5](=[O:6])[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)-[n:13]1[c:14]2[n:15][cH:16][cH:17][cH:18][c:19]2[c:20]([nH:21][c:22]1=[O:23])=[O:24]>O.CN(C)C=O.[NaH]>[CH2:1]=[CH:2][CH2:3][n:21]1[c:20]([c:19]2[cH:18][cH:17][cH:16][n:15][c:14]2[n:13]([c:22]1=[O:23])-[c:11]1[cH:10][cH:9][cH:8][c:7]([cH:12]1)[N+:5]([O-:4])=[O:6])=[O:24]|EP0990653A1_0527
7.3.5|[C:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][c:6]1[n:7][n:8][c:9]2[CH2:10][N:11]=[C:12]([c:13]3[cH:14][c:15]([cH:16][cH:17][c:18]3-[n:19]12)[Cl:20])[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>Cl.C1CCOC1.B>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][c:6]1[n:7][n:8][c:9]2[CH2:10][NH:11][CH:12]([c:13]3[cH:14][c:15]([cH:16][cH:17][c:18]3-[n:19]12)[Cl:20])[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1|US04448776A
1.1.5|[c:5]-[C&H2&+0&D2:4]-Br.[c:3]:[n&H0&+0&D2:2]:[c:1]>>[c:5]-[C&H2&+0&D2:4]-[n&H0&+&D3:2](:[c:3]):[c:1]|[OH:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][n:7][cH:8]1.Br[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>CC(C)=O>[OH:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][n+:7]([cH:8]1)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|
1.6.8|[C:5]=[C&H1&+0&D2:4]-I.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:5]=[C&H1&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH:2]([CH3:3])[O:4][c:5]1[cH:6][c:7]([cH:8][c:9]([n:10]1)[C:11]([F:12])([F:13])[F:14])-[c:15]1[n:16][cH:17][nH:18][n:19]1.[CH3:20][CH:21]([CH3:22])[O:23][C:24](=[O:25])/[CH:26]=[CH:27]\I>CN(C)C=O.O[Na]>[CH3:1][CH:2]([CH3:3])[O:4][c:5]1[cH:6][c:7]([cH:8][c:9]([n:10]1)[C:11]([F:12])([F:13])[F:14])-[c:15]1[n:16][cH:17][n:18]([n:19]1)/[CH:27]=[CH:26]\[C:24](=[O:25])[O:23][CH:21]([CH3:20])[CH3:22]|US20190023693A1_0494
7.3.5|[C:5]-[C&H0&+0&D3:4](-[c:3])=[N&H0&+0&D2:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[N&H1&+0&D2:2]-[c:1]|[cH:1]1[cH:2][c:3]2[CH2:4][CH2:5][N:6]3[c:7]4[cH:8][cH:9][cH:10][cH:11][c:12]4[N:13]=[C:14]([c:15]([cH:16]1)[c:17]23)[CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1>O.[Na+].Cl.C1CCOC1.[OH-]>[cH:8]1[cH:9][cH:10][cH:11][c:12]2[NH:13][CH:14]([c:15]3[cH:16][cH:1][cH:2][c:3]4[CH2:4][CH2:5][N:6]([c:7]12)[c:17]43)[CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1|US20200347021A1_0848
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[N:2])-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[N:2])-[c:1]|[CH:1]1[CH2:2][CH2:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[C:10]=1[N:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1>Cl.CCOCC.O=C(O[K])O[K].[Li][AlH4]>[cH:7]1[cH:6][cH:5][c:4]2[CH2:3][CH2:2][CH2:1][CH:10]([c:9]2[cH:8]1)[N:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1|US20060160794A1_0158
1.1.6|[C:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4]Cl.[cH:5]1[cH:6][cH:7][n:8][cH:9][cH:10]1>>[CH3:1][CH2:2][CH2:3][CH2:4][n+:8]1[cH:7][cH:6][cH:5][cH:10][cH:9]1|EP2995630A1_0040
1.2.9|[C:5]-[C&H2&+0&D2:4]-O.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([n:7]1)[NH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.O[CH2:15][CH2:16][CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)/N=N/C(=O)OCC.ClCCl>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([n:7]1)[N:8]([CH2:15][CH2:16][CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1)[c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1|EP2240485B1_0954
3.10.2|[C:5]-[C&H2&+0&D2:4]-I.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1-[n:10]1[cH:11][cH:12][cH:13][cH:14]1.[CH3:15][CH2:16][O:17][C:18](=[O:19])[CH2:20]I>O=S1(O[Fe]O1)=O.CS(C)=O.OO.O.O.O.O.O.O.O.O>[CH3:15][CH2:16][O:17][C:18](=[O:19])[CH2:20][c:11]1[cH:12][cH:13][cH:14][n:10]1-[c:9]1[cH:8][cH:7][cH:6][cH:5][c:4]1[N+:2]([O-:1])=[O:3]|EP0665227A1_0082
7.3.5|[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[N:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[N:1]|[N:1]#[C:2][CH2:3][C:4]([C:5]#[N:6])=[N:7][NH:8][c:9]1[c:10]([cH:11][c:12]([cH:13][c:14]1[Cl:15])[C:16]([F:17])([F:18])[F:19])[Cl:20]>O=C(O)O[Na].CC(=O)O.N#C[Na].O>[N:6]#[C:5][CH:4]([CH2:3][C:2]#[N:1])[NH:7][NH:8][c:9]1[c:10]([cH:11][c:12]([cH:13][c:14]1[Cl:15])[C:16]([F:17])([F:18])[F:19])[Cl:20]|EP3442975B1_0115
3.11.34|[C:5]-[C&H1&+0&D2:4]=O.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C:5]/[C&H1&+0&D2:4]=[C&H0&+0&D3:2](\[C:3])-[c:1]|[O:1]=[C:2]1[CH2:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[NH:10]1)[Cl:11].[CH3:12][C:13]([CH3:14])([CH3:15])[CH2:16][CH:17]=O>C1CCNC1.CO>[CH3:12][C:13]([CH3:14])([CH3:15])[CH2:16]/[CH:17]=[C:3]1\[C:2]([NH:10][c:9]2[cH:8][c:7]([cH:6][cH:5][c:4]12)[Cl:11])=[O:1]|EP1996590B1_0097
1.2.9|[C:5]-[C&H2&+0&D2:4]-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][C:3](=[O:4])[C:5]1([CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[NH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.O[CH2:18][CH2:19][c:20]1[cH:21][cH:22][cH:23][s:24]1>CC(=O)CC(C)C.O=C(O[Na])O[Na]>[CH3:1][CH2:2][C:3](=[O:4])[C:5]1([CH2:6][CH2:7][N:8]([CH2:9][CH2:10]1)[CH2:18][CH2:19][c:20]1[cH:21][cH:22][cH:23][s:24]1)[NH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US07629336B2_0263
7.3.5|[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[O:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[O:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][O:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[CH2:13][CH2:14][CH2:15][C:16]([CH2:17][CH2:18][CH3:19])=[N:20][O:21][CH:22]([c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1>[Na+].Cl.CO.N#C[BH3-].O=C(O)O[Na]>[CH3:1][O:2][C:3](=[O:4])[CH2:5][O:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[CH2:13][CH2:14][CH2:15][CH:16]([CH2:17][CH2:18][CH3:19])[NH:20][O:21][CH:22]([c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1|US10472345B2_0236
1.2.9|[C:5]-[N&H1&+0&D2:4]-[C:3].[C:2]=[C&H1&+0&D2:1]-O>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H1&+0&D2:1]=[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1.[CH3:12][O:13][c:14]1[cH:15][c:16]2[NH:17][C:18]([C:19]([c:20]2[cH:21][c:22]1[O:23][CH3:24])=[CH:25]O)=[O:26]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][N:9]([CH2:10][CH2:11]1)[CH:25]=[C:19]1[C:18]([NH:17][c:16]2[cH:15][c:14]([c:22]([cH:21][c:20]12)[O:23][CH3:24])[O:13][CH3:12])=[O:26]|US07538112B2_0778
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[S:2])-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[S:2])-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[N:5]1[C:6]([CH:7]=[C:8]([S:9]1(=[O:10])=[O:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[CH2:18][OH:19])=[O:20]>C1CCOC1.[Li+].[BH4-]>[CH3:1][C:2]([CH3:3])([CH3:4])[N:5]1[C:6]([CH2:7][CH:8]([S:9]1(=[O:10])=[O:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[CH2:18][OH:19])=[O:20]|US07141596B2_1574
3.11.34|[C:5]-[C&H1&+0&D2:4]=O.[C:3]-[C&H2&+0&D2:2]-[S:1]>>[C:5]/[C&H1&+0&D2:4]=[C&H0&+0&D3:2](/[C:3])-[S:1]|[CH3:1][c:2]1[o:3][c:4]([n:5][c:6]1[CH2:7][O:8][CH:9]1[CH2:10][CH2:11][CH2:12][CH:13]([CH2:14]1)[O:15][CH2:16][CH:17]=O)-[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[F:24].[O:25]=[C:26]1[NH:27][C:28]([CH2:29][S:30]1)=[O:31]>CCCC[Li]>[CH3:1][c:2]1[o:3][c:4]([n:5][c:6]1[CH2:7][O:8][CH:9]1[CH2:10][CH2:11][CH2:12][CH:13]([CH2:14]1)[O:15][CH2:16]/[CH:17]=[C:29]1\[S:30][C:26]([NH:27][C:28]1=[O:31])=[O:25])-[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[F:24]|EP2365969B1_0233
1.1.5|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][P:22]([O-:23])(=[O:24])[O:25][CH2:26][CH2:27]Br.[cH:28]1[cH:29][cH:30][n:31][cH:32][cH:33]1>>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][P:22]([O-:23])(=[O:24])[O:25][CH2:26][CH2:27][n+:31]1[cH:30][cH:29][cH:28][cH:33][cH:32]1|EP0040039B1_0028
1.1.3|[C&H3&+0&D1:4]-I.[C&H3&D1:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C&H3&D1:3])-[c:1]|[CH3:1]I.[CH3:2][NH:3][c:4]1[n:5][c:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n:13]1[CH2:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21])=[O:22]>O.O.CN(C)C(C)=O.[NaH]>[CH3:2][N:3]([CH3:1])[c:4]1[n:5][c:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n:13]1[CH2:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21])=[O:22]|US20190159450A1_0279
7.3.5|[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[CH2:7][N:8]1[CH2:9][CH2:10][C:11]([CH2:12][CH2:13]1)=[N:14][c:15]1[cH:16][cH:17][cH:18][n:19][cH:20]1>[Na+].CCO.[BH4-]>[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[CH2:7][N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[NH:14][c:15]1[cH:20][n:19][cH:18][cH:17][cH:16]1|EP3197900B1_0227
3.11.91|[C:5]-[C&H2&+0&D2:4]-I.[C:3]-[C&H2&+0&D2:2]-[S:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[S:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][S:6](=[O:7])(=[O:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[CH3:15].I[CH2:16][CH2:17][CH2:18][CH2:19]/[CH:20]=[C:21](/[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[c:28]1[cH:29][n:30][cH:31][cH:32][cH:33]1>O.CN(C)C=O.[NaH]>[CH3:15][c:12]1[cH:13][cH:14][c:9]([cH:10][cH:11]1)[S:6](=[O:7])(=[O:8])[CH:5]([CH2:16][CH2:17][CH2:18][CH2:19]/[CH:20]=[C:21](/[c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1)[c:28]1[cH:33][cH:32][cH:31][n:30][cH:29]1)[C:3](=[O:4])[O:2][CH3:1]|US20110105544A1_0694
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[S:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[S:1]|[CH3:1][c:2]1[o:3][c:4]([n:5][c:6]1[CH2:7][O:8][C@@H:9]1[CH2:10][CH2:11][CH2:12][C@@H:13]([CH2:14]1)[O:15][CH2:16][CH:17]=[C:18]1[S:19][C:20]([NH:21][C:22]1=[O:23])=[O:24])-[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[F:31]>[H][H]>[CH3:1][c:2]1[o:3][c:4]([n:5][c:6]1[CH2:7][O:8][C@@H:9]1[CH2:10][CH2:11][CH2:12][C@@H:13]([CH2:14]1)[O:15][CH2:16][CH2:17][CH:18]1[S:19][C:20]([NH:21][C:22]1=[O:23])=[O:24])-[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[F:31]|US20200062743A1_0222
7.6.1|[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[N:1]>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[C&H2&+0&D2:2]-[N:1]|[CH3:1][N:2]1[CH:3]=[C:4]2[c:5]3[cH:6][cH:7][cH:8][cH:9][c:10]3[CH:11]3[CH2:12][C:13]2([CH2:14]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]13>CC(=O)O.[H][H].[Pd]>[CH3:1][N:2]1[CH2:3][CH:4]2[c:5]3[cH:6][cH:7][cH:8][cH:9][c:10]3[CH:11]3[CH2:12][C:13]2([CH2:14]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]13|US20090012054A1_0247
8.2.1|[C&H3&D1:4]-[S&H0&+0&D2:3]-[C:2].[O&H1&+0&D1:1]-O>>[C&H3&D1:4]-[S&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]|[CH3:1][S:2][CH2:3][c:4]1[cH:5][n+:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n+:13]1[O-:14])[O-:15].[OH:16]O>O.CC(=O)O>[CH3:1][S:2](=[O:16])[CH2:3][c:4]1[cH:5][n+:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n+:13]1[O-:14])[O-:15]|US20170275270A1_2305
7.6.1|[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:2]-[c:1]|[CH3:1][CH2:2][C:3](=[CH:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[C:11](=[O:12])[OH:13]>O[Na].[H][H].[Pd]>[CH3:1][CH2:2][CH:3]([CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[C:11](=[O:12])[OH:13]|US05142056A
7.6.1|[C:5]/[C&H0&+0&D3:4](-[N:3])=[C&H1&+0&D2:2]/[c:1]>>[C:5]-[C&H1&+0&D3:4](-[N:3])-[C&H2&+0&D2:2]-[c:1]|[CH3:1][C:2](=[O:3])[NH:4]/[C:5](=[CH:6]\[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[C:13](=[O:14])[OH:15]>[H][H]>[CH3:1][C:2](=[O:3])[NH:4][CH:5]([CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[C:13](=[O:14])[OH:15]|EP2909197B1_0426
3.11.34|[C:5]-[C&H1&+0&D2:4]=O.[C:3]-[C&H2&+0&D2:2]-[O:1]>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[O:1]|[CH3:1][c:2]1[s:3][c:4]([n:5][c:6]1-[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[CH2:13][CH2:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[CH:21]=[CH:22][CH:23]=O.[O:24]=[C:25]1[CH2:26][O:27][C:28]([NH:29]1)=[O:30]>CCO.C1CCNCC1>[CH3:1][c:2]1[s:3][c:4]([n:5][c:6]1-[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[CH2:13][CH2:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[CH:21]=[CH:22][CH:23]=[C:26]1[O:27][C:28]([NH:29][C:25]1=[O:24])=[O:30]|US08598387B2_0128
3.11.34|[C:5]-[C&H1&+0&D2:4]=O.[C:3]-[C&H2&+0&D2:2]-[S:1]>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[S:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]=O.[O:6]=[C:7]1[CH2:8][S:9][C:10]([N:11]1[N:12]=[c:13]1[s:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[s:21]1)=[S:22]>COCCOC.CC(=O)O.C1CCNCC1>[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]=[C:8]1[S:9][C:10]([N:11]([C:7]1=[O:6])[N:12]=[c:13]1[s:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[s:21]1)=[S:22]|US20140357641A1_0266
1.6.8|[C:5]-[N&H1&+0&D2:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-I>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([n:8]([n:9]1)-[c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[C:16](=[O:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[Cl:24])[CH2:25]I.[CH2:26]1[CH2:27][NH:28][CH2:29][CH2:30][O:31]1>CO>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:9][n:8]([c:7]([n:6]1)[CH2:25][N:28]1[CH2:29][CH2:30][O:31][CH2:26][CH2:27]1)-[c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[C:16](=[O:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[Cl:24]|US09546164B2_2110
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[n:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[n:1]|[CH3:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([n:7]([c:8]2[cH:9][cH:10]1)[C:11]1=[CH:12][CH2:13][N:14]([CH2:15][CH2:16]1)[CH2:17][CH2:18][N:19]1[CH2:20][CH2:21][NH:22][C:23]1=[O:24])[CH3:25])-[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[F:32]>[NH4+].CCO.[O-]C=O.[Pd]>[CH3:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([n:7]([c:8]2[cH:9][cH:10]1)[CH:11]1[CH2:12][CH2:13][N:14]([CH2:15][CH2:16]1)[CH2:17][CH2:18][N:19]1[CH2:20][CH2:21][NH:22][C:23]1=[O:24])[CH3:25])-[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[F:32]|US08883806B2_0878
1.2.9|[C:5]-[N&H1&+0&D2:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-O>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][c:6]1[n:7][n:8][c:9]([n:10]1-[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[C:17](=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[Cl:25])[Cl:26])[CH2:27]O.[O:28]=[C:29]1[NH:30][C:31]([c:32]2[c:33]1[cH:34][cH:35][cH:36][cH:37]2)=[O:38]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)N=NC(=O)OCC.COCCOC>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][c:6]1[n:7][n:8][c:9]([n:10]1-[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[C:17](=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[Cl:25])[Cl:26])[CH2:27][N:30]1[C:31]([c:32]2[cH:37][cH:36][cH:35][cH:34][c:33]2[C:29]1=[O:28])=[O:38]|US20050245575A1_0190
8.8.18|[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:2]-[C:1]>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[C:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:12]([CH2:13][CH:14]2[C:15]=1[CH2:16][CH2:17][CH:18]([CH:19]2[CH3:20])[OH:21])=[O:22]>CC1C(CCC2=C(C(CC21)=O)CCCCCCC(=O)O)O>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1=[C:15]2[CH2:16][CH2:17][CH:18]([CH:19]([C:14]2=[CH:13][C:12]1=[O:22])[CH3:20])[OH:21]|EP2384328B1_0083
1.1.3|[C&H3&+0&D1:4]-I.[C&H3&D1:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C&H3&D1:3])-[C:1]|[CH3:1]I.[CH3:2][n:3]1[c:4]([c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[c:11]1[C:12](=[O:13])[NH:14][CH3:15])[Cl:16])-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O.O.CN(C)C=O.CC(C)(C)[O-].[K+]>[CH3:15][N:14]([CH3:1])[C:12](=[O:13])[c:11]1[c:10]2[cH:9][cH:8][c:7]([cH:6][c:5]2[c:4]([n:3]1[CH3:2])-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[Cl:16]|EP2579887B1_0300
1.2.1|[C:5]-[C&H1&+0&D2:4]=O.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[NH:7][CH2:8][CH2:9][CH2:10][c:11]2[cH:12]1.[CH3:13][CH2:14][CH:15]=O>CCO.[Pd]>[CH3:13][CH2:14][CH2:15][N:7]1[CH2:8][CH2:9][CH2:10][c:11]2[cH:12][c:3]([cH:4][cH:5][c:6]21)[O:2][CH3:1]|EP1836163B1_0246
9.5.4|[C&H3&D1:4]-[C&H1&+0&D3:3](-[C&H2&+0&D2:2]-[C:1])-O>>[C&H3&D1:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]|[CH3:1][n:2]1[c:3]([n:4]([c:5]2[n:6][cH:7][n:8]([c:9]2[c:10]1=[O:11])[CH2:12][CH2:13][CH2:14][CH2:15][CH:16]([CH3:17])O)[CH3:18])=[O:19]>O.C=CCCCCn1cnc2c1c(n(c(n2C)=O)C)=O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O.CCOCC>[CH3:17][CH:16]=[CH:15][CH2:14][CH2:13][CH2:12][n:8]1[cH:7][n:6][c:5]2[c:9]1[c:10]([n:2]([c:3]([n:4]2[CH3:18])=[O:19])[CH3:1])=[O:11]|US09012391B2_0470
3.11.91|[C:5]-[C&H2&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-I>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][CH3:13].[Cl:14][c:15]1[n:16][cH:17][c:18]([c:19]([n:20]1)[Cl:21])[CH2:22]I>CCOC(C)=O.CC(C)NC1CCCCC1.CCCC[Li].C1CCOC1>[CH3:13][O:12][c:9]1[cH:10][cH:11][c:6]([cH:7][cH:8]1)[CH:5]([CH2:22][c:18]1[cH:17][n:16][c:15]([n:20][c:19]1[Cl:21])[Cl:14])[C:3](=[O:4])[O:2][CH3:1]|US07465808B2_0764
3.5.2|[C&H3&+0&D1:4]-[#12]-Br.[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Cl:1][c:2]1[n:3][c:4]([n:5][c:6]([n:7]1)Cl)-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.C1CCOC1.[CH3:14][Mg]Br>C1CCOC1.O>[CH3:14][c:6]1[n:5][c:4]([n:3][c:2]([n:7]1)[Cl:1])-[c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1|US08901141B2_2587
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[c:2])-[n:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[c:2])-[n:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]1=[CH:10][CH2:11][CH2:12][c:13]2[cH:14][n:15][cH:16][n:17]12>CCOC(C)=O.[H][H].[Pd]>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[CH2:10][CH2:11][CH2:12][c:13]2[cH:14][n:15][cH:16][n:17]21|US06855722B2_00434
1.6.8|[C:5]-[N&H1&+0&D2:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-I>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[O:1]=[c:2]1[nH:3][c:4]2[cH:5][cH:6][cH:7][c:8]([c:9]2[n:10]1[CH:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1)[Cl:17].[F:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[CH:25]([CH2:26][CH2:27][CH2:28]I)[c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[F:35]>CC(=O)CC(C)C.O=C(O[Na])O[Na]>[O:1]=[c:2]1[nH:3][c:4]2[cH:5][cH:6][cH:7][c:8]([c:9]2[n:10]1[CH:11]1[CH2:16][CH2:15][N:14]([CH2:13][CH2:12]1)[CH2:28][CH2:27][CH2:26][CH:25]([c:22]1[cH:21][cH:20][c:19]([cH:24][cH:23]1)[F:18])[c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[F:35])[Cl:17]|US06472410B1
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][c:6]1[cH:7][c:8]2[O:9][C:10]([CH:11]=[C:12]([c:13]2[c:14]([cH:15]1)[O:16][CH3:17])[c:18]1[cH:19][cH:20][n:21][cH:22][cH:23]1)([CH3:24])[CH3:25]>CCO.[Pd]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][c:6]1[cH:15][c:14]([c:13]2[c:8]([cH:7]1)[O:9][C:10]([CH2:11][CH:12]2[c:18]1[cH:19][cH:20][n:21][cH:22][cH:23]1)([CH3:24])[CH3:25])[O:16][CH3:17]|US08222416B2_0674
2.1.18|[N&H2&+0&D1:4]-[c:3].[O&H0&D1:2]=[C&H1&+0&D2:1]-O>>[N&H1&+0&D2:4](-[c:3])-[C&H1&+0&D2:1]=[O&H0&D1:2]|[CH3:1][CH2:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][c:8]([cH:9][c:10]([c:11]1[C:12](=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[NH2:20])[C:21](=[O:22])[OH:23].[O:24]=[CH:25]O>>[CH3:1][CH2:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][c:8]([cH:9][c:10]([c:11]1[C:12](=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[NH:20][CH:25]=[O:24])[C:21](=[O:22])[OH:23]|US09738596B2_0204
7.3.5|[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[n:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[n:1]|[O:1]=[c:2]1[cH:3][c:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[n:11]1/[N:12]=[C:13]1\[CH2:14][CH2:15][CH2:16]1)[OH:17]>CCN(CC)c1ccccc1.C1CCOC1.B>[O:1]=[c:2]1[cH:3][c:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[n:11]1[NH:12][CH:13]1[CH2:14][CH2:15][CH2:16]1)[OH:17]|EP2361913A1_0859
7.6.1|[C:5]/[C&H1&+0&D2:4]=[C&H0&+0&D3:3](\[C:2])-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]|[O:1]=[C:2]([OH:3])[CH2:4][O:5][c:6]1[cH:7][cH:8][cH:9][c:10]2[C:11](/[CH2:12][CH2:13][CH2:14][c:15]12)=[CH:16]/[CH2:17][C:18](=[O:19])[NH:20][CH:21]([c:22]1[cH:23][n:24][cH:25][cH:26][cH:27]1)[c:28]1[cH:29][n:30][cH:31][cH:32][cH:33]1>>[O:19]=[C:18]([CH2:17][CH2:16][CH:11]1[CH2:12][CH2:13][CH2:14][c:15]2[c:6]([cH:7][cH:8][cH:9][c:10]21)[O:5][CH2:4][C:2](=[O:1])[OH:3])[NH:20][CH:21]([c:28]1[cH:33][cH:32][cH:31][n:30][cH:29]1)[c:22]1[cH:27][cH:26][cH:25][n:24][cH:23]1|US20180230166A1_0289
8.8.18|[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]1[CH2:8][CH2:9][CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21>O=C(O)CC1CCCc2ccccc21>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]1=[CH:8][CH2:9][CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]12|US06818658B2
7.6.1|[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[C:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:2]-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]=[C:7]1[CH2:8][CH2:9][N:10]([CH2:11][CH2:12]1)[C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CCO.[Pd]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]1[CH2:8][CH2:9][N:10]([CH2:11][CH2:12]1)[C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US05776940A
3.11.34|[C:5]-[C&H2&+0&D2:4]-[S:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:5]-[C&H0&+0&D3:4](-[S:3])=[C&H1&+0&D2:1]-[c:2]|O=[CH:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[OH:10].[O:11]=[C:12]1[CH2:13][S:14][C:15]([NH:16]1)=[S:17]>O.[Na+].CC(=O)O.CC([O-])=O>[O:11]=[C:12]1[NH:16][C:15]([S:14][C:13]1=[CH:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[OH:10])=[S:17]|US08580832B2_0237
9.7.157|[C&H0&-&D1:4]#[N&H0&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H0&+0&D2:4](#[N&H0&D1:3])-[C&H2&+0&D2:1]-[C:2]|[Na+].[C-:1]#[N:2].[CH3:3][C:4](=[O:5])[O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[CH2:14][CH2:15][CH2:16]Cl>O.CCOCC.CS(C)=O>[CH3:3][C:4](=[O:5])[O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[CH2:14][CH2:15][CH2:16][C:1]#[N:2]|EP0250725A1_0253
3.11.2|[C:5]-[C&H2&+0&D2:4]-[c:3].[N:2]-[C&H1&+0&D2:1]=O>>[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:1]-[N:2]|[CH3:1][N:2]([CH3:3])[CH:4]=O.[O:5]=[C:6]([OH:7])[CH2:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][C:17](=[O:18])[C:19](=[O:20])[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>O.Cl.COC(OC)N(C)C>[CH3:1][N:2]([CH3:3])[CH:4]=[C:16]([C:17](=[O:18])[C:19](=[O:20])[c:21]1[cH:26][cH:25][cH:24][cH:23][cH:22]1)[c:13]1[cH:14][cH:15][c:10]([cH:11][cH:12]1)[CH2:9][CH2:8][C:6](=[O:5])[OH:7]|US10329298B2_1045
3.11.91|[C:5]-[C&H2&+0&D2:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-I>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][C:3](=[O:4])[CH2:5][C:6](=[O:7])[CH2:8][CH3:9].I[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][c:18]1[cH:19][cH:20][c:21]2[O:22][CH2:23][O:24][c:25]2[cH:26]1>[Li]>[CH3:1][CH2:2][C:3](=[O:4])[CH:5]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][c:18]1[cH:19][cH:20][c:21]2[O:22][CH2:23][O:24][c:25]2[cH:26]1)[C:6](=[O:7])[CH2:8][CH3:9]|US20160137639A1_3293
1.2.10|[C&H2&+0&D1:4]=O.[C&H3&D1:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&+0&D1:4]-[N&H0&+0&D3:2](-[C&H3&D1:3])-[C:1]|[CH2:1]=O.[CH3:2][NH:3][CH:4]1[CH2:5][CH2:6][CH2:7][N:8]([CH2:9]1)[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>CCO.[H][H].[O-2].[Pt+2]>[CH3:2][N:3]([CH3:1])[CH:4]1[CH2:5][CH2:6][CH2:7][N:8]([CH2:9]1)[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US20200239470A1_0299
7.6.1|[N:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[c:1]>>[N:5]-[C&H1&+0&D3:4](-[c:3])-[C&H2&+0&D2:2]-[c:1]|[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]2[S:7][c:8]3[cH:9][cH:10][c:11]([cH:12][c:13]3[CH:14]=[C:15]([c:16]2[cH:17]1)[N:18]1[CH2:19][CH2:20][N:21]([CH2:22][CH2:23]1)[CH3:24])[CH3:25]>[Na+].COCCOCCOC.O=C(O)C(=O)O.[BH4-]>[CH3:24][N:21]1[CH2:22][CH2:23][N:18]([CH2:19][CH2:20]1)[CH:15]1[CH2:14][c:13]2[cH:12][c:11]([cH:10][cH:9][c:8]2[S:7][c:6]2[cH:5][cH:4][c:3]([cH:17][c:16]21)[S:2][CH3:1])[CH3:25]|EP0066773A1_0017
3.11.34|[C:5]-[C&H2&+0&D2:4]-[C:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[O:9][CH3:10])[N+:11]([O-:12])=[O:13])[CH:14]=O.[N:15]#[C:16][CH2:17][C:18]([NH2:19])=[O:20]>CO.C1CCNCC1>[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[O:9][CH3:10])[N+:11]([O-:12])=[O:13])[CH:14]=[C:17]([C:16]#[N:15])[C:18]([NH2:19])=[O:20]|US06248743B1
1.6.8|[C:5]-[C&H2&+0&D2:4]-I.[C:3]-[N&H1&+0&D2:2]-[S:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[S:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[n:6][cH:7][n:8][c:9]([c:10]2[cH:11][c:12]1[O:13][CH3:14])[N:15]1[CH2:16][CH2:17][CH:18]([CH2:19][CH2:20]1)[CH2:21]I.[O:22]=[S:23]1([N:24]=[CH:25][CH:26]=[CH:27][NH:28]1)=[O:29]>CN(C)C=O.[NaH]>[CH3:14][O:13][c:12]1[cH:11][c:10]2[c:5]([cH:4][c:3]1[O:2][CH3:1])[n:6][cH:7][n:8][c:9]2[N:15]1[CH2:16][CH2:17][CH:18]([CH2:19][CH2:20]1)[CH2:21][N:28]1[CH:27]=[CH:26][CH:25]=[N:24][S:23]1(=[O:22])=[O:29]|EP3555068B1_0185
7.5.1|[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&D1:4]-[C&H1&+0&D3:3](-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([CH3:8])=[O:9]>O.CCCCCCC(C)=O.CC(C)PCc1ccccc1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([CH3:8])[OH:9]|US07186729B2_1161
7.6.1|[C:5]-[C&H0&+0&D3:4](-[N:3])=[C&H1&+0&D2:2]-[N:1]>>[C:5]-[C&H1&+0&D3:4](-[N:3])-[C&H2&+0&D2:2]-[N:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[CH:7][NH:8][CH2:9][CH2:10][N:11]1[C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18]>CC(=O)O.[H][H].[O-2].[O-2].[Pt+4]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:7][NH:8][CH2:9][CH2:10][N:11]1[C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18]|US08178490B2_0596
7.5.1|[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&D1:4]-[C&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1>O.CCO.CC(=O)c1ccccc1.CC(C)PCc1ccccc1>[CH3:1][CH:2]([OH:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1|EP1399441B1_0296
7.6.1|[C:5]-[C&H0&+0&D3:4](-[S:3])=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[S:3])-[C&H2&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][c:4]([o:5][n:6]1)[CH:7]=[C:8]1[S:9][C:10]([N:11]([C:12]1=[O:13])[CH2:14][C:15](=[O:16])[OH:17])=[S:18]>O.O=C(O)O[Na].[Pd]>[CH3:1][c:2]1[cH:3][c:4]([o:5][n:6]1)[CH2:7][CH:8]1[S:9][C:10]([N:11]([C:12]1=[O:13])[CH2:14][C:15](=[O:16])[OH:17])=[S:18]|US08236786B2_0224
7.6.1|[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[N:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:2]-[N:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]1=[CH:6][N:7]2[CH2:8][CH2:9][N:10]([C:11]([CH:12]2[CH2:13]1)=[O:14])[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>CCOC(C)=O.[H][H].[Pd]>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:13][CH:12]2[C:11]([N:10]([CH2:9][CH2:8][N:7]2[CH2:6]1)[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)=[O:14]|US09902693B2_0132
1.2.9|[C:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-O>>[C:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][NH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.O[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>c1ccc(cc1)OP(Oc1ccccc1)Oc1ccccc1.O>[CH3:1][CH2:2][N:3]([CH2:10][c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1)[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1|US09394263B2_0902
7.6.1|[c:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[c:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[CH:1](=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[c:15]1[n:16][c:17]([cH:18][o:19]1)[CH2:20][O:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[CH2:28][CH2:29][CH2:30][n:31]1[cH:32][n:33][cH:34][cH:35]1>>[cH:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[CH:2]([CH2:1][c:15]1[n:16][c:17]([cH:18][o:19]1)[CH2:20][O:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[CH2:28][CH2:29][CH2:30][n:31]1[cH:35][cH:34][n:33][cH:32]1)[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|US20200291016A1_0387
1.2.9|[C:5]-[C&H2&+0&D2:4]-O.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][NH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.O[CH2:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>c1ccc(cc1)OP(Oc1ccccc1)Oc1ccccc1.O>[CH3:1][CH2:2][N:3]([CH2:10][CH2:11][c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1)[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1|US20170027172A1_0195
7.3.5|[c:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[c:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]|[cH:1]1[cH:2][cH:3][cH:4][c:5]2[C:6](=[N:7][c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[O:14][c:15]12)[c:16]1[cH:17][cH:18][n:19][cH:20][cH:21]1>[Na+].[BH4-]>[cH:20]1[cH:21][c:16]([cH:17][cH:18][n:19]1)[CH:6]1[NH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[O:14][c:15]2[cH:1][cH:2][cH:3][cH:4][c:5]21|US08399452B2_0721
7.3.5|[C:5]-[C&H0&+0&D3:4](-[c:3])=[N&H0&+0&D2:2]-[N:1]>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[N&H1&+0&D2:2]-[N:1]|[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10]([F:11])([F:12])[F:13])[N:14]1[CH2:15][CH:16]([C:17](=[N:18]1)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25])[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>CC(C)C[AlH]CC(C)C.C1CCOC1>[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10]([F:11])([F:12])[F:13])[N:14]1[CH2:15][CH:16]([CH:17]([NH:18]1)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25])[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1|US20070185093A1_0154
3.11.91|[C:5]-[C&H2&+0&D2:4]-I.[C:3]-[C&H2&+0&D2:2]-[N:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[N:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][N:7]=[CH:8][c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)[O:15][CH3:16])[O:17][CH3:18].[CH3:19][O:20][c:21]1[cH:22][c:23]([cH:24][cH:25][c:26]1[O:27][CH3:28])[C:29]([C:30]#[N:31])([CH2:32][CH2:33][CH2:34]I)[CH:35]([CH3:36])[CH3:37]>>[CH3:16][O:15][c:13]1[cH:14][c:9]([cH:10][cH:11][c:12]1[O:17][CH3:18])[CH:8]=[N:7][CH:6]([CH2:34][CH2:33][CH2:32][C:29]([C:30]#[N:31])([c:23]1[cH:24][cH:25][c:26]([c:21]([cH:22]1)[O:20][CH3:19])[O:27][CH3:28])[CH:35]([CH3:36])[CH3:37])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|EP3030562B1_0332
1.2.9|[C:5]-[C&H2&+0&D2:4]-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[c:2]1[n:3][cH:4][c:5]([cH:6][nH:7]1)[Cl:8].[CH3:9][C:10]1([CH2:11][S:12][CH2:13]1)[CH2:14]O>CC(C)(C)COC(OCC(C)(C)C)N(C)C.CN(C)C=O>[CH3:9][C:10]1([CH2:11][S:12][CH2:13]1)[CH2:14][n:7]1[cH:6][c:5]([cH:4][n:3][c:2]1=[O:1])[Cl:8]|US10323000B2_0934
9.7.155|[C&H0&-&D1:4]#[N&H0&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H0&+0&D2:4](#[N&H0&D1:3])-[C&H2&+0&D2:1]-[c:2]|[C-:1]#[N:2].[O-:3][N+:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[CH2:12]Br)[S:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[Br:20]>CCO>[N:2]#[C:1][CH2:12][c:10]1[cH:11][c:6]([cH:7][cH:8][c:9]1[S:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[Br:20])[N+:4]([O-:3])=[O:5]|US20200115374A1_1007
1.6.8|[C:5]-[C&H2&+0&D2:4]-I.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3]I.[cH:4]1[cH:5][c:6]([cH:7][cH:8][n:9]1)-[c:10]1[n:11][c:12]([nH:13][n:14]1)-[c:15]1[cH:16][cH:17][n:18][cH:19][cH:20]1>CN(C)C=O.C1CCOC1.[NaH]>[CH3:1][CH2:2][CH2:3][n:13]1[n:14][c:10]([n:11][c:12]1-[c:15]1[cH:20][cH:19][n:18][cH:17][cH:16]1)-[c:6]1[cH:7][cH:8][n:9][cH:4][cH:5]1|US09434725B2_0316
1.2.1|[C:5]-[N&H1&+0&D2:4]-[C:3].[C:2]-[C&H1&+0&D2:1]=O>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]1=[CH:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[CH:8]([CH3:9])[CH2:10][CH:11]=O.[CH2:12]1[CH2:13][CH2:14][NH:15][CH2:16]1>>[CH3:1][C:2]1=[CH:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[CH:8]([CH3:9])[CH2:10][CH2:11][N:15]1[CH2:14][CH2:13][CH2:12][CH2:16]1|US06509351B1
8.8.18|[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[N:2])-[c:1]>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[N:2])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]2[CH:10]([CH2:11][CH2:12][CH:13]([n:14]2[c:15]1=[O:16])[CH3:17])[N:18]([CH3:19])[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>ClC(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]2[C:10](=[CH:11][CH2:12][CH:13]([n:14]2[c:15]1=[O:16])[CH3:17])[N:18]([CH3:19])[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US20160159795A1_0493
1.6.8|[C:5]-[C&H2&+0&D2:4]-I.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[S:9](=[O:10])(=[O:11])[NH:12][c:13]1[cH:14][cH:15][cH:16][c:17]([c:18]1/[CH:19]=[CH:20]/[c:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1)[F:27].[OH:28][CH2:29][CH2:30]I>O=C(O[K])O[K].C1CCOC1>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[S:9](=[O:10])(=[O:11])[N:12]([CH2:30][CH2:29][OH:28])[c:13]1[cH:14][cH:15][cH:16][c:17]([c:18]1/[CH:19]=[CH:20]/[c:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1)[F:27]|US20200360357A1_0568
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H2&+&D2:2]-[C:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[Cl-].[CH3:1][CH:2]1[CH2:3][O:4][CH2:5][CH:6]([NH2+:7]1)[CH3:8].[O:9]=[C:10]1[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[C:17]([N:18]1[CH2:19][CH2:20]Br)=[O:21]>>[CH3:1][CH:2]1[CH2:3][O:4][CH2:5][CH:6]([N:7]1[CH2:20][CH2:19][N:18]1[C:10]([c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[C:17]1=[O:21])=[O:9])[CH3:8]|EP3104846B1_0082
3.11.34|[C:5]-[C&H2&+0&D2:4]-[C:3].[C:2]-[C&H1&+0&D2:1]=O>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:1]-[C:2]|O=[CH:1][CH:2]=[CH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[O:10]=[C:11]1[NH:12][C:13]([CH2:14][C:15]([NH:16]1)=[O:17])=[O:18]>O>[O:18]=[C:13]1[NH:12][C:11]([NH:16][C:15]([C:14]1=[CH:1][CH:2]=[CH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)=[O:17])=[O:10]|US20200317673A1_0918
3.11.34|[C:5]-[C&H1&+0&D2:4]=O.[C:3]-[C&H2&+0&D2:2]-[N:1]>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[N:1]|O=[CH:1][CH:2]=[CH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[O:10]=[C:11]1[NH:12][C:13]([CH2:14][NH:15]1)=[O:16]>O.CC(=O)O>[O:16]=[C:13]1[NH:12][C:11]([NH:15][C:14]1=[CH:1][CH:2]=[CH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)=[O:10]|US20200031760A1_0125
7.6.1|[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C&H3&D1:2])-[C:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:3](-[C&H3&D1:2])-[C:1]|[CH2:1]=[C:2]([CH3:3])[CH:4]1[CH2:5][CH2:6][C:7](=[C:8]1[CH2:9][CH:10]([CH3:11])[CH2:12][OH:13])[CH3:14]>CO.[Ni]>[CH3:14][C:7]1[CH2:6][CH2:5][CH:4]([C:8]=1[CH2:9][CH:10]([CH3:11])[CH2:12][OH:13])[CH:2]([CH3:3])[CH3:1]|US09681664B2_0201
3.11.34|[C:5]-[C&H2&+0&D2:4]-[N:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:5]-[C&H0&+0&D3:4](-[N:3])=[C&H1&+0&D2:1]-[c:2]|O=[CH:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[OH:8])[OH:9].[O:10]=[C:11]1[NH:12][C:13]([CH2:14][NH:15]1)=[O:16]>O.NCCO>[O:16]=[C:13]1[NH:12][C:11]([NH:15][C:14]1=[CH:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[OH:8])[OH:9])=[O:10]|US09303033B2_0522
1.2.1|[C:5]-[C&H1&+0&D2:4]=O.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[NH:12][c:13]1[cH:14][cH:15][c:16]2[c:17]([cH:18]1)[C:19]([O:20][C:21]2([CH3:22])[CH3:23])([CH3:24])[CH3:25].[CH3:26][CH2:27][CH:28]=O>[Na+].CC(=O)O.N#C[BH3-].C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:11][cH:10][c:9]([cH:8][cH:7]1)[N:12]([CH2:28][CH2:27][CH3:26])[c:13]1[cH:14][cH:15][c:16]2[c:17]([cH:18]1)[C:19]([O:20][C:21]2([CH3:22])[CH3:23])([CH3:24])[CH3:25]|US20070293530A1_0406
9.7.92|[N&H2&+0&D1:4]-[O&H1&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:4](-[O&H1&D1:3])=[C&H1&+0&D2:1]-[c:2]|Cl.[CH3:1][N:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[N+:10]([O-:11])=[O:12])[CH:13]=O.[NH2:14][OH:15]>O.[Na+].CCO.CC([O-])=O>[CH3:1][N:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[N+:10]([O-:11])=[O:12])[CH:13]=[N:14][OH:15]|US08592446B2_0271
3.11.35|[C:5]-[C&H2&+0&D2:4]-[c:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:1]-[c:2]|[O:1]=[C:2]([OH:3])[CH2:4][c:5]1[cH:6][cH:7][cH:8][s:9]1.O=[CH:10][c:11]1[cH:12][cH:13][cH:14][o:15]1>CCN(CC)CC.CC(=O)OC(C)=O.O[K].O.C>[O:1]=[C:2]([OH:3])[C:4](=[CH:10][c:11]1[cH:12][cH:13][cH:14][o:15]1)[c:5]1[cH:6][cH:7][cH:8][s:9]1|US20110124634A1_0473
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[O:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[O:1]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[O:11][C:12]1=[CH:13][CH2:14][N:15]([CH2:16][CH2:17]1)[CH2:18][CH2:19][CH2:20][N:21]([c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[O:34]=[C:35]([OH:36])[C:37](=[O:38])[OH:39]>CC(=O)O.CO.[H][H].[Pd]>[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[O:11][CH:12]1[CH2:17][CH2:16][N:15]([CH2:14][CH2:13]1)[CH2:18][CH2:19][CH2:20][N:21]([c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[O:38]=[C:37]([OH:39])[C:35](=[O:34])[OH:36]|US20180125821A1_0897
3.11.91|[C:5]-[C&H2&+0&D2:4]-I.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[c:7]([cH:8][cH:9][n:10]1[CH2:11][CH2:12]I)[C:13](=[O:14])[O:15][CH3:16]>CN(C)C=O.[NaH]>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:12][CH2:11][n:10]2[cH:9][cH:8][c:7]([c:6]12)[C:13](=[O:14])[O:15][CH3:16]|EP3689864A1_0124
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[O:2])-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[O:2])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]=[C:6]1[O:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[O:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]12>CO>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH:6]1[O:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[O:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21|US20130109682A1_1049
7.6.1|[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[O:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:2]-[O:1]|[CH3:1][O:2][C:3](=[O:4])[C:5](=[CH:6][O:7][CH2:8][CH2:9][Cl:10])[CH2:11][CH3:12]>CCO.[H][H].[Ni]>[CH3:12][CH2:11][CH:5]([CH2:6][O:7][CH2:8][CH2:9][Cl:10])[C:3](=[O:4])[O:2][CH3:1]|US20120157448A1_0327
9.7.12|[N&H2&+0&D1:4]-[c:3].[S&H0&D1:2]=[C&H0&+0&D2:1]=S>>[N&H0&+0&D2:4](-[c:3])=[C&H0&+0&D2:1]=[S&H0&D1:2]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][CH2:9][CH2:10][N:11]1[CH2:12][CH2:13][CH2:14][CH2:15]1.[S:16]=[C:17]=S>N.CCO>[S:16]=[C:17]=[N:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][CH2:9][CH2:10][N:11]1[CH2:12][CH2:13][CH2:14][CH2:15]1|US20200062711A1_0344
3.11.2|[C:5]-[C&H2&+0&D2:4]-[C:3].[N:2]-[C&H1&+0&D2:1]=O>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:1]-[N:2]|[CH3:1][C:2](=[O:3])[NH:4][CH:5]1[CH2:6][CH2:7][C:8]([CH2:9][CH2:10]1)=[O:11].[CH3:12][N:13]([CH3:14])[CH:15]=O>>[CH3:1][C:2](=[O:3])[NH:4][CH:5]1[CH2:10][CH2:9][C:8]([C:7]([CH2:6]1)=[CH:15][N:13]([CH3:12])[CH3:14])=[O:11]|EP2440554B1_0205
1.2.9|[N:5]-[C&H2&+0&D2:4]-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[N:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[N:1]#[C:2][c:3]1[c:4]([c:5]([nH:6][c:7]1-[c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[Cl:14])[Cl:15])[Cl:16])[Cl:17].[CH3:18][C:19](=[O:20])[NH:21][CH2:22]O.CC(=O)O>CCOC(C)=O.C1CCOC1.ClCCl.ClCCl.O.[NaH]>[CH3:18][C:19](=[O:20])[NH:21][CH2:22][n:6]1[c:5]([c:4]([c:3]([c:7]1-[c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[Cl:14])[Cl:15])[C:2]#[N:1])[Cl:17])[Cl:16]|US07244747B2_0503
7.6.1|[C:5]/[C&H1&+0&D2:4]=[C&H0&+0&D3:3](\[C:2])-[N:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[N:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:7])[CH2:8]/[CH:9]=[C:10]1[C:11]([NH:12][C:13]([N:14]\1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21](=[O:22])[OH:23])=[O:24])=[O:25]>CCO.CCOCC.C>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:7])[CH2:8][CH2:9][CH:10]1[C:11]([NH:12][C:13]([N:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21](=[O:22])[OH:23])=[O:24])=[O:25]|US20180327367A1_1435
7.6.1|[C:5]-[C&H0&+0&D3:4](-[N:3])=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[N:3])-[C&H2&+0&D2:2]-[c:1]|[CH3:1][C:2](=[O:3])[NH:4][C:5](=[CH:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[C:13](=[O:14])[OH:15]>C1=CCCC=CCC1.CCN(CC)CC.CCO.Cl[Rh].PP.[H][H]>[CH3:1][C:2](=[O:3])[NH:4][CH:5]([CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[C:13](=[O:14])[OH:15]|US09745313B2_0997
7.6.1|[O:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[O:2])-[c:1]>>[O:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[O:2])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[NH:5][c:6]1[n:7][c:8]2[c:9]([cH:10][cH:11][c:12]([c:13]2[s:14]1)[C:15]1=[CH:16][O:17][CH2:18][CH2:19][O:20]1)[O:21][CH3:22]>CC(=O)O.C1COCCO1.[H][H].[Pd]>[CH3:1][O:2][C:3](=[O:4])[NH:5][c:6]1[n:7][c:8]2[c:9]([cH:10][cH:11][c:12]([c:13]2[s:14]1)[CH:15]1[CH2:16][O:17][CH2:18][CH2:19][O:20]1)[O:21][CH3:22]|US20050245572A1_0167
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H0&-&D2:2]-[C:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[Na+].[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[C:12](=[O:13])[CH2:14]Br.[O:15]=[CH:16][N-:17][CH:18]=[O:19]>CC#N.N#Cc1ccccc1C(=O)CN(C=O)C=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[C:12](=[O:13])[CH2:14][N:17]([CH:18]=[O:19])[CH:16]=[O:15]|US20200109148A1_0977
2.6.2|[C:4]-[O&H1&+0&D1:3].[Cl&H0&D1:2]-[C&H2&+0&D2:1]-I>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[Cl&H0&D1:2]|[O:1]=[C:2]([OH:3])[CH2:4][NH:5][C:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[Cl:25][CH2:26]I>CCN(CC)CC.CN(C)C=O.O>[O:1]=[C:2]([CH2:4][NH:5][C:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[O:3][CH2:26][Cl:25]|EP3030566B1_0238
8.1.5|[C&H3&D1:4]-[C&H1&+0&D3:3](-[C:2])-[O&H1&+0&D1:1]>>[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]|[CH3:1][CH:2]([OH:3])[CH2:4][CH2:5][CH2:6][CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[F:20]>C(=NC1CCCCC1)=NC1CCCCC1.O=C(O)C(F)(F)F.O=C(O)C(=O)O.c1ccccc1.c1ccncc1.CCOCC.CS(C)=O.CO.O.O.O>[CH3:1][C:2](=[O:3])[CH2:4][CH2:5][CH2:6][CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[F:20]|US20180297922A1_0086
1.2.1|[C:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|O=[CH:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[cH:8]1[cH:9][cH:10][c:11]2[CH2:12][CH2:13][CH2:14][NH:15][c:16]2[cH:17]1>[Na+].Cl.CO.CC(=O)O.N#C[BH3-]>[cH:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH2:1][N:15]1[CH2:14][CH2:13][CH2:12][c:11]2[cH:10][cH:9][cH:8][cH:17][c:16]21|EP2096109A1_0132
1.6.8|[O:5]-[C&H2&+0&D2:4]-I.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[O:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][cH:7][cH:8][n:9][c:10]1[NH:11][S:12](=[O:13])(=[O:14])[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[S:22][C:23]([F:24])([F:25])[F:26].[CH3:27][O:28][CH2:29]I>CCN(C(C)C)C(C)C>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][cH:7][cH:8][n:9][c:10]1[N:11]([CH2:29][O:28][CH3:27])[S:12](=[O:13])(=[O:14])[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[S:22][C:23]([F:24])([F:25])[F:26]|EP2039681A1_0178
1.2.9|[c:5]-[C&H2&+0&D2:4]-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|O[CH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[OH:8].[cH:9]1[cH:10][nH:11][cH:12][n:13]1>>[OH:8][c:5]1[cH:6][cH:7][c:2]([cH:3][cH:4]1)[CH2:1][n:11]1[cH:12][n:13][cH:9][cH:10]1|US07572809B2_1899
1.6.8|[C:5]-[C&H2&+0&D2:4]-I.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][CH2:2][CH2:3]I.[O-:4][N+:5](=[O:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[NH:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20]>CCO.CN(C)C=O.CCOC(C)=O.[O-][N+](=O)c1ccc(cc1)Nc1ccc(cc1)Cl.[O-][N+](=O)c1ccc(cc1)O.[O-][N+](=O)c1ccccc1.[OH-].[K+]>[CH3:1][CH2:2][CH2:3][N:13]([c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20])[c:10]1[cH:9][cH:8][c:7]([cH:12][cH:11]1)[N+:5]([O-:4])=[O:6]|US20190233384A1_0074
1.2.2|[N&H2&+0&D1:4]-[N&H2&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:4](-[N&H2&D1:3])=[C&H1&+0&D2:1]-[c:2]|O.[Na+:1].[NH2:2][NH2:3].[O-:4][S:5](=[O:6])(=[O:7])[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[CH:14]=O>CO.CC(C)O>[Na+:1].[NH2:3][N:2]=[CH:14][c:13]1[cH:12][cH:11][cH:10][cH:9][c:8]1[S:5]([O-:4])(=[O:6])=[O:7]|EP2128138A1_1018
3.5.2|[C&H3&+0&D1:4]-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][c:8]([c:9]([n:10][c:11]2[cH:12]1)Cl)[F:13].[CH3:14][Mg]Br>[NH4+].[Cl-].O[Na].Br[Cu].C1CCOC1>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][c:8]([c:9]([n:10][c:11]2[cH:12]1)[CH3:14])[F:13]|US20200407353A1_0347
3.11.34|[c:5]-[C&H1&+0&D2:4]=O.[c:3]-[C&H2&+0&D2:2]-[c:1]>>[c:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][C:2]([CH3:3])([c:4]1[cH:5][c:6]2[cH:7][cH:8][cH:9][n:10][c:11]2[c:12]([cH:13]1)-[c:14]1[cH:15][c:16]([cH:17][cH:18][cH:19]1)[CH:20]=O)[S:21]([CH3:22])(=[O:23])=[O:24].[CH3:25][S:26](=[O:27])(=[O:28])[c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[CH2:35][c:36]1[n:37][c:38]([n:39][o:40]1)[CH3:41]>C1CCNCC1>[CH3:25][S:26](=[O:27])(=[O:28])[c:29]1[cH:34][cH:33][c:32]([cH:31][cH:30]1)[C:35](=[CH:20][c:16]1[cH:17][cH:18][cH:19][c:14]([cH:15]1)-[c:12]1[cH:13][c:4]([cH:5][c:6]2[cH:7][cH:8][cH:9][n:10][c:11]21)[C:2]([CH3:1])([CH3:3])[S:21]([CH3:22])(=[O:23])=[O:24])[c:36]1[n:37][c:38]([n:39][o:40]1)[CH3:41]|US20190194385A1_0057
7.6.1|[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[O:1]>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[C&H2&+0&D2:2]-[O:1]|[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10]1=[CH:11][O:12][CH2:13][CH2:14][CH2:15]1>CCO.[Ni]>[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH:10]1[CH2:11][O:12][CH2:13][CH2:14][CH2:15]1|US20120225062A1_0771
1.2.1|[C:5]-[N&H1&+0&D2:4]-[C:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[CH3:8])-[c:9]1[cH:10][cH:11][c:12]([o:13]1)[CH:14]=O.[cH:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[N:21]1[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]1>[Na+].Cl.CO.CO.N#C[BH3-]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[CH3:8])-[c:9]1[cH:10][cH:11][c:12]([o:13]1)[CH2:14][N:24]1[CH2:25][CH2:26][N:21]([CH2:22][CH2:23]1)[c:18]1[cH:19][cH:20][cH:15][cH:16][cH:17]1|US07598391B2_2045
9.7.155|[C&H0&-&D1:4]#[N&H0&D1:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H0&+0&D2:4](#[N&H0&D1:3])-[C&H2&+0&D2:1]-[C:2]|[C-:1]#[N:2].[O:3]=[C:4]([CH2:5]Br)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[F:18])[F:19].[K+]>CC(=O)c1ccc(cc1)-c1ccc(cc1F)F>[N:2]#[C:1][CH2:5][C:4](=[O:3])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[F:18])[F:19]|US20180201592A1_0432
7.6.1|[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C&H3&D1:2])-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:3](-[C&H3&D1:2])-[c:1]|[CH2:1]=[C:2]([CH3:3])[c:4]1[cH:5][cH:6][n:7][cH:8][c:9]1[CH:10]1[C:11]([CH:12]=[C:13]([CH2:14][C:15]1([OH:16])[C:17]([CH3:18])=[O:19])[CH:20]([CH3:21])[CH:22]([CH3:23])[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])([OH:29])[C:30]([CH3:31])=[O:32]>CCOC(C)=O.[Pd]>[CH3:28][CH2:27][CH2:26][CH2:25][CH2:24][CH:22]([CH3:23])[CH:20]([CH3:21])[C:13]1=[CH:12][C:11]([CH:10]([C:15]([CH2:14]1)([OH:16])[C:17]([CH3:18])=[O:19])[c:9]1[cH:8][n:7][cH:6][cH:5][c:4]1[CH:2]([CH3:3])[CH3:1])([OH:29])[C:30]([CH3:31])=[O:32]|US20190374542A1_0887
7.6.1|[N:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[O:1]>>[N:5]-[C&H1&+0&D3:4](-[c:3])-[C&H2&+0&D2:2]-[O:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][O:11][CH:12]=[C:13]1[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[C:20](=[O:21])[O:22][CH3:23]>CO.[OH-].[OH-].[Pd+2]>[CH3:23][O:22][C:20](=[O:21])[c:17]1[cH:16][cH:15][c:14]([cH:19][cH:18]1)[CH:13]1[CH2:12][O:11][CH2:10][CH2:9][N:8]1[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20100280243A1_0099
3.5.2|[C&H3&+0&D1:4]-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][n:2]1[n:3][cH:4][c:5]([c:6]([c:7]1=[O:8])Br)[Br:9].[CH3:10][Mg]Br>Cl.CCOCC.Cn1ncc(c(c1=O)Br)Br>[CH3:10][c:6]1[c:5]([cH:4][n:3][n:2]([c:7]1=[O:8])[CH3:1])[Br:9]|US20190119418A1_0190
1.2.1|[N&H2&+0&D1:4]-[O&H1&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H1&+0&D2:4](-[O&H1&D1:3])-[C&H2&+0&D2:1]-[c:2]|Cl.[NH2:1][OH:2].O=[CH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[I:10]>O.CO.C1CCOC1.[OH-].[K+]>[OH:2][NH:1][CH2:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[I:10]|US20110184029A1_0278
3.5.4|[C&H3&+0&D1:4]-[#12]-Cl.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|Cl[c:1]1[n:2][c:3]([cH:4][c:5]2[c:6]1[cH:7][cH:8][cH:9][cH:10]2)[Cl:11].[CH3:12][Mg]Cl>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.BrBr.[Zn]>[CH3:12][c:1]1[n:2][c:3]([cH:4][c:5]2[c:6]1[cH:7][cH:8][cH:9][cH:10]2)[Cl:11]|US20200299242A1_0155
9.5.4|[C&H3&D1:4]-[C&H2&+0&D2:3]-[C&H1&+0&D3:2](-[c:1])-O>>[C&H3&D1:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH:3](O)[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[Br:10]>Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][CH:2]=[CH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[Br:10]|US20200283446A1_0263
7.3.5|[C:5]-[C&H0&+0&D3:4](-[c:3])=[N&H0&+0&D2:2]-[S:1]>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[N&H1&+0&D2:2]-[S:1]|[CH3:1][C:2]1([NH:3][S:4]([N:5]=[C:6]1[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[Cl:13])(=[O:14])=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22]>[Na+].CCO.[BH4-]>[CH3:1][C:2]1([NH:3][S:4]([NH:5][CH:6]1[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[Cl:13])(=[O:14])=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22]|US08063065B2_0732
3.11.2|[C:5]-[C&H1&+0&D2:4]=O.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][N:2]([CH3:3])[N:4]=[CH:5][CH:6]=O.[O:7]=[C:8]([CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>O.[Na+].Cc1ccccc1.CC[O-].CCO.CCOC(C)=O.[Na]>[CH3:1][N:2]([CH3:3])[N:4]=[CH:5][CH:6]=[C:9]([C:8](=[O:7])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US20140094465A1_0447
8.2.1|[C&H3&D1:4]-[S&H0&+0&D2:3]-[c:2].[O&H1&+0&D1:1]-O>>[C&H3&D1:4]-[S&H0&+0&D3:3](=[O&H0&+0&D1:1])-[c:2]|[CH3:1][C:2]1=[CH:3][c:4]2[cH:5][c:6]([cH:7][cH:8][c:9]2[CH:10]1[CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[S:18][CH3:19])[F:20].[OH:21]O>CC(=O)O.ClC(Cl)Cl>[CH3:1][C:2]1=[CH:3][c:4]2[cH:5][c:6]([cH:7][cH:8][c:9]2[CH:10]1[CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[S:18]([CH3:19])=[O:21])[F:20]|US04584384A
8.1.5|[C&H3&D1:4]-[C&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]>>[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]|[CH3:1][CH:2]([OH:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[Cl:10])-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>CC(C)=O.O=[Cr](=O)=O>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[Cl:10])-[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US09775841B2_0664
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][c:2]1[cH:3][s:4][c:5]([n:6]1)[C:7]1=[CH:8][CH2:9][N:10]([CH2:11][CH2:12]1)[CH2:13][CH2:14][CH2:15][CH:16]([OH:17])[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[F:24]>CCO.[Pd]>[CH3:1][c:2]1[cH:3][s:4][c:5]([n:6]1)[CH:7]1[CH2:8][CH2:9][N:10]([CH2:11][CH2:12]1)[CH2:13][CH2:14][CH2:15][CH:16]([OH:17])[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[F:24]|US06326381B1
7.3.5|[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[C:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[C:1]|[Cl:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH2:8][C:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]=1>[Pt]>[Cl:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH2:8][CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15]1|EP2632457B1_0083
7.6.1|[C:5]-[C&H0&+0&D3:4](-[O:3])=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[O:3])-[C&H2&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[C:7](=[CH:8][c:9]1[cH:10][cH:11][cH:12][n:13][cH:14]1)[O:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22]>CC(=O)O.[Zn]>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH:7]([CH2:8][c:9]1[cH:14][n:13][cH:12][cH:11][cH:10]1)[O:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22]|US06884821B1_0269
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[N:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[N:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9](=[O:10])[CH:11]=[C:12]1[CH2:13][CH2:14][CH2:15][N:16]1[CH3:17]>O.CCOCC.C1CCOC1.[Li][AlH4]>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9](=[O:10])[CH2:11][CH:12]1[CH2:13][CH2:14][CH2:15][N:16]1[CH3:17]|US07326719B2_0101
1.6.8|[C:5]-[C&H2&+0&D2:4]-I.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4]I.[CH3:5][O:6][C:7](=[O:8])[CH:9]1[CH2:10][C:11]([NH:12][c:13]2[cH:14][c:15]([cH:16][cH:17][c:18]2[C:19]1=[O:20])[Cl:21])=[O:22]>Cl.CN(C)C=O.[NaH]>[CH3:1][CH2:2][CH2:3][CH2:4][N:12]1[C:11]([CH2:10][CH:9]([C:19]([c:18]2[cH:17][cH:16][c:15]([cH:14][c:13]21)[Cl:21])=[O:20])[C:7](=[O:8])[O:6][CH3:5])=[O:22]|US09556200B2_0988
7.3.5|[C:5]-[C&H0&+0&D3:4](-[c:3])=[N&H0&+0&D2:2]-[O:1]>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[N&H1&+0&D2:2]-[O:1]|[CH2:1]=[CH:2][CH2:3][O:4][N:5]=[C:6]1[CH2:7][N:8]([NH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]12)[C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22]>CC[O+](CC)[B-](F)(F)F.N#C[BH3-].CO.[Na+]>[CH2:1]=[CH:2][CH2:3][O:4][NH:5][CH:6]1[CH2:7][N:8]([NH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)[C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22]|US08653003B2_0090
7.3.5|[C:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][n:2]1[n:3][n:4][n:5][c:6]1[S:7][CH2:8][C:9]1=[N:10][CH2:11][CH2:12][c:13]2[cH:14][c:15]([c:16]([cH:17][c:18]12)[O:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[O:27][CH2:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1>[Na+].CO.[BH4-]>[CH3:1][n:2]1[n:3][n:4][n:5][c:6]1[S:7][CH2:8][CH:9]1[NH:10][CH2:11][CH2:12][c:13]2[cH:14][c:15]([c:16]([cH:17][c:18]21)[O:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[O:27][CH2:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1|EP3027619B1_0213
1.6.4|[C:5]-[C&H2&+0&D2:4]-Cl.[C:3]-[N&H1&+0&D2:2]-[N:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[N:1]|[CH3:1][O:2][CH2:3][C:4](=[O:5])[N:6]([NH:7][C:8](=[O:9])[O:10][CH2:11][CH2:12]Cl)[c:13]1[c:14]([cH:15][cH:16][cH:17][c:18]1[CH3:19])[CH3:20]>Cc1ccccc1.[NaH]>[CH3:20][c:14]1[cH:15][cH:16][cH:17][c:18]([c:13]1[N:6]([C:4](=[O:5])[CH2:3][O:2][CH3:1])[N:7]1[CH2:12][CH2:11][O:10][C:8]1=[O:9])[CH3:19]|US20180086764A1_0350
1.6.4|[C:5]-[N&H1&+0&D2:4]-[n:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4](-[n:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][c:2]1[n:3][c:4]([cH:5][s:6]1)[CH2:7]Cl.[CH3:8][c:9]1[cH:10][cH:11][c:12]([n:13]1[NH:14][C:15](=[O:16])[CH2:17][Cl:18])[CH3:19]>CN(C)C=O.[NaH]>[CH3:1][c:2]1[n:3][c:4]([cH:5][s:6]1)[CH2:7][N:14]([C:15](=[O:16])[CH2:17][Cl:18])[n:13]1[c:12]([cH:11][cH:10][c:9]1[CH3:8])[CH3:19]|EP0416814A2_0158
1.6.4|[c:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|Cl[CH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[cH:8]1[cH:9][c:10]([cH:11][cH:12][n:13]1)-[c:14]1[n:15][c:16]([n:17][nH:18]1)-[c:19]1[cH:20][cH:21][n:22][cH:23][cH:24]1>CN(C)C=O.C1CCOC1.[NaH]>[cH:12]1[cH:11][c:10]([cH:9][cH:8][n:13]1)-[c:14]1[n:15][c:16]([n:17][n:18]1[CH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)-[c:19]1[cH:20][cH:21][n:22][cH:23][cH:24]1|US07402680B2_0873
1.6.2|[C:5]#[C&H0&+0&D2:4]-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:5]#[C&H0&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]2[c:5]3[CH2:6][CH2:7][N:8]([CH2:9][c:10]3[nH:11][c:12]2[cH:13][cH:14]1)[CH3:15].[Cl:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[C:23]#[C:24]Br>c1ccc2ccc3cccnc3c2n1.Cc1ccccc1.O=S1(O[Cu]O1)=O.[O-]P([O-])([O-])=O.O.O.O.O.O.[K+].[K+].[K+]>[CH3:15][N:8]1[CH2:7][CH2:6][c:5]2[c:4]3[cH:3][c:2]([cH:14][cH:13][c:12]3[n:11]([c:10]2[CH2:9]1)[C:24]#[C:23][c:20]1[cH:19][cH:18][c:17]([cH:22][cH:21]1)[Cl:16])[CH3:1]|US08906925B2_1162
1.6.4|[C:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][c:7]([s:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.Cl[CH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[Cl:28]>CN(C)C=O.I[Na].[NaH]>[O:1]=[C:2]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[N:3]([CH2:21][c:22]1[cH:27][cH:26][c:25]([cH:24][cH:23]1)[Cl:28])[c:4]1[cH:5][cH:6][c:7]([s:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|EP1836163B1_0274
1.6.2|[C:5]=[C&H1&+0&D2:4]-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:5]=[C&H1&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]1[CH2:3][CH2:4][c:5]2[c:6]3[cH:7][c:8]([cH:9][cH:10][c:11]3[nH:12][c:13]2[CH2:14]1)[Cl:15].[CH3:16][C:17](=[CH:18]Br)[c:19]1[cH:20][cH:21][c:22]([c:23]([cH:24]1)[Cl:25])[Cl:26]>O=C(O)[C@@H]1CCCN1.CN(C)C=O.[O-]P([O-])([O-])=O.I[Cu].[K+].[K+].[K+]>[CH3:1][N:2]1[CH2:3][CH2:4][c:5]2[c:6]3[cH:7][c:8]([cH:9][cH:10][c:11]3[n:12]([c:13]2[CH2:14]1)[CH:18]=[C:17]([CH3:16])[c:19]1[cH:20][cH:21][c:22]([c:23]([cH:24]1)[Cl:25])[Cl:26])[Cl:15]|US09458155B2_0876
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[S:3])-[c:1]|[O-:1][n+:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[S:8](=[O:9])(=[O:10])[NH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[C:18]([F:19])([F:20])[F:21].[CH2:22]=[CH:23][CH2:24]Br>CN(C)C=O.[Na+].[H-]>[CH2:22]=[CH:23][CH2:24][N:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[C:18]([F:19])([F:20])[F:21])[S:8](=[O:9])(=[O:10])[c:7]1[cH:6][cH:5][cH:4][cH:3][n+:2]1[O-:1]|EP2560976B1_0414
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]-[N&H1&+0&D2:2]-[n:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[n:1]|[CH3:1][CH2:2][CH2:3]Br.[CH3:4][c:5]1[cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n:13]1[NH:14][c:15]1[cH:16][cH:17][n:18][cH:19][c:20]1[F:21]>[Na+].[H-]>[CH3:4][c:5]1[cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n:13]1[N:14]([CH2:3][CH2:2][CH3:1])[c:15]1[cH:16][cH:17][n:18][cH:19][c:20]1[F:21]|US07745472B2_0522
3.10.2|[c:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H1&+0&D2:2]:[o:1]>>[c:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][o:9]1.[CH3:10][c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[CH2:17]Br>ClC(Cl)(Cl)Cl.[Cl-].[Cl-].[Cl-].[Fe+3]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([o:9]1)[CH2:17][c:16]1[cH:15][cH:14][cH:13][cH:12][c:11]1[CH3:10]|US07691882B2_2282
1.6.2|[c:5]-[C&H2&+0&D2:4]-Br.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][N:2]1[C:3]([c:4]2[cH:5][s:6][cH:7][c:8]2[NH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)=[O:16].Br[CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>CN(C)C=O.[NaH]>[CH3:1][N:2]1[C:3]([c:4]2[cH:5][s:6][cH:7][c:8]2[N:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)[CH2:17][c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1)=[O:16]|US07381736B2_0522
3.11.91|[C:5]-[C&H2&+0&D2:4]-[n:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[C&H1&+0&D3:4](-[n:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH2:7][n:8]1[cH:9][n:10][cH:11][n:12]1.[Cl:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20]Br>CN(C)C=O.O.[NaH]>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH:7]([CH2:20][c:17]1[cH:16][cH:15][c:14]([cH:19][cH:18]1)[Cl:13])[n:8]1[cH:9][n:10][cH:11][n:12]1|EP3197872B1_0466
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H1&+0&D2:2]-[n:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[NH:6][n:7]1[cH:8][cH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21.[CH3:16][CH2:17][CH2:18]Br>O.CC(C)(C)[O-].C1CCOC1.[K+]>[CH3:16][CH2:17][CH2:18][N:6]([C:4](=[O:5])[O:3][CH2:2][CH3:1])[n:7]1[cH:8][cH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21|US20140296068A1_0144
3.11.91|[C:5]-[C&H2&+0&D2:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2](=[O:3])[CH2:4][C:5]([CH3:6])=[O:7].[OH:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[CH2:15]Cl>O.Cl.CNC>[CH3:6][C:5](=[O:7])[CH:4]([CH2:15][c:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[OH:8])[C:2]([CH3:1])=[O:3]|US20090264650A1_3613
3.11.91|[C:5]-[C&H2&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1.Cl[CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[Cl:19])[Cl:20]>c1ccccc1.CN(C)C=O.[NaH]>[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[Cl:19])[Cl:20])[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1|EP2474530A1_0181
1.8.19|[C:5]-[S&H0&+0&D2:4]-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([o:7]1)=[O:8])[OH:9].[CH3:10][CH2:11][S:12]Cl>Cl.Cc1ccccc1>[CH3:10][CH2:11][S:12][c:5]1[c:4]([cH:3][c:2]([o:7][c:6]1=[O:8])[CH3:1])[OH:9]|US06849633B2_00191
3.11.83|[C:5]-[C&H2&+0&D2:4]-[C:3].[N:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[N:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[O:9][CH2:10][CH3:11].[CH3:12][N:13]([CH2:14]Cl)[n:15]1[cH:16][c:17]([c:18]([c:19]2[cH:20][c:21]([c:22]([c:23]([c:24]21)[F:25])[F:26])[F:27])=[O:28])[C:29](=[O:30])[O:31][CH2:32][CH3:33]>O.CCOC(C)=O.CN(C)C=O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH2:14][N:13]([CH3:12])[n:15]1[cH:16][c:17]([c:18]([c:19]2[cH:20][c:21]([c:22]([c:23]([c:24]21)[F:25])[F:26])[F:27])=[O:28])[C:29](=[O:30])[O:31][CH2:32][CH3:33])[C:7](=[O:8])[O:9][CH2:10][CH3:11]|US20190233425A1_0643
3.11.91|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[C&H2&+0&D2:2]-[N:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[N:1]|[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][C:7]1=[O:8])[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH3:16][CH:17]([CH3:18])[CH2:19]Br>CN(C)P(=O)(N(C)C)N(C)C.CC(C)NC(C)C.CCOC(C)=O.CCCC[Li].C1CCOC1>[CH3:16][CH:17]([CH3:18])[CH2:19][CH:6]1[C:7]([N:2]([CH2:3][CH2:4][N:5]1[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[CH3:1])=[O:8]|US20100311798A1_0147
1.6.4|[C:5]-[C&H2&+0&D2:4]-Cl.[C:3]-[N&H1&+0&D2:2]-[O:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[O:1]|[CH3:1][CH2:2][O:3][P:4](=[O:5])([CH2:6][CH2:7][CH2:8]Cl)[O:9][CH2:10][CH3:11].[CH3:12][CH2:13][O:14][C:15](=[O:16])[O:17][NH:18][C:19](=[O:20])[O:21][CH2:22][CH3:23]>CN(C)C=O.[K]>[CH3:12][CH2:13][O:14][C:15](=[O:16])[O:17][N:18]([CH2:8][CH2:7][CH2:6][P:4](=[O:5])([O:3][CH2:2][CH3:1])[O:9][CH2:10][CH3:11])[C:19](=[O:20])[O:21][CH2:22][CH3:23]|US20080085893A1_0419
1.6.4|[O:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[O:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|Cl[CH2:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[Cl:9].[cH:10]1[n:11][cH:12][nH:13][n:14]1>CC#N>[Cl:9][c:6]1[cH:7][cH:8][c:3]([cH:4][cH:5]1)[O:2][CH2:1][n:13]1[cH:12][n:11][cH:10][n:14]1|EP3666758A1_1256
3.11.91|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]1([C:3]([CH2:4][CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21)=[O:12])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]Br>CC12CCCCC(Cc3ccc(cc31)OC)C2=O.CN(C)C=O.[NaH]>[CH3:1][C:2]12[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:4]([CH2:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]31)[C:3]2=[O:12]|US20160137639A1_3197
3.11.91|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1([C:7]([CH2:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21)=[O:15])[CH2:16][CH2:17][CH2:18]Br>c1ccccc1.O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]12[CH2:16][CH2:17][CH2:18][CH:8]([C:7]2=[O:15])[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21|EP3030556B1_0208
3.11.91|[C:5]-[C&H2&+0&D2:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[CH2:9][CH2:10][C:11]([C:12]2([CH3:13])[CH2:14][CH2:15][CH2:16][CH2:17]Cl)=[O:18]>O=C1C2=Cc3ccccc3C1C=CC=C2>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[CH2:9][CH:10]1[CH2:17][CH2:16][CH2:15][CH2:14][C:12]2([C:11]1=[O:18])[CH3:13]|EP3331886B1_0502
1.6.4|[C:5]-[N&H1&+0&D2:4]-[C:3].[S:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[S:2]|[O:1]=[c:2]1[c:3]([cH:4][n:5]([c:6]2[cH:7][c:8]([c:9]([cH:10][c:11]12)[F:12])[N:13]1[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]1)[CH:19]1[CH2:20][CH2:21]1)[C:22](=[O:23])[OH:24].[F:25][C:26]([F:27])([F:28])[S:29][CH2:30]Cl>CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)CC.CN(C)C=O.I[K].O.[I-]>[O:23]=[C:22]([OH:24])[c:3]1[cH:4][n:5]([c:6]2[cH:7][c:8]([c:9]([cH:10][c:11]2[c:2]1=[O:1])[F:12])[N:13]1[CH2:14][CH2:15][N:16]([CH2:17][CH2:18]1)[CH2:30][S:29][C:26]([F:25])([F:27])[F:28])[CH:19]1[CH2:20][CH2:21]1|US20070004740A1_0096
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H1&+0&D2:2]-[S:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[S:1]|[CH3:1][C:2](=[O:3])[O:4][CH:5]([CH2:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[F:14])[CH2:15][CH2:16][CH2:17][NH:18][S:19]([CH3:20])(=[O:21])=[O:22].[CH3:23][O:24][C:25](=[O:26])[CH2:27][CH2:28][CH2:29][C:30]#[C:31][CH2:32]Br>c1ccccc1.CN(C)C=O.O.Cl.[H][H].[NaH]>[CH3:23][O:24][C:25](=[O:26])[CH2:27][CH2:28][CH2:29][C:30]#[C:31][CH2:32][N:18]([CH2:17][CH2:16][CH2:15][CH:5]([CH2:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[F:14])[O:4][C:2]([CH3:1])=[O:3])[S:19]([CH3:20])(=[O:21])=[O:22]|EP3138840B1_0127
1.8.19|[c:5]-[S&H0&+0&D2:4]-Cl.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[c:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][nH:7][cH:8][cH:9]1.[CH3:10][c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[S:17]Cl>CCOCC.ClCCl.ClC(Cl)Cl>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][nH:7][c:8]([cH:9]1)[S:17][c:16]1[cH:15][cH:14][cH:13][cH:12][c:11]1[CH3:10]|EP0949249B1_0047
3.10.2|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O-:1][N+:2](=[O:3])[c:4]1[n:5][cH:6][cH:7][nH:8]1.[OH:9][B:10]([OH:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[CH2:18][CH2:19]Br>CN(C)C=O.O=C(O[K])O[K]>[O-:1][N+:2](=[O:3])[c:4]1[n:5][c:6]([cH:7][nH:8]1)[CH2:19][CH2:18][c:15]1[cH:16][cH:17][c:12]([cH:13][cH:14]1)[B:10]([OH:9])[OH:11]|US20180327391A1_0825
9.7.334|[c:4]:[n&H0&+0&D2:3]:[n&H0&+0&D3:2](:[c:1])-C1-C-C-C-C-O-1>>[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[c:1]|[CH3:1][N:2]([CH2:3][C:4]1([CH2:5][c:6]2[c:7]([O:8]1)[c:9]([c:10]([c:11]([c:12]2[CH3:13])[N+:14]([O-:15])=[O:16])[CH3:17])[CH3:18])[CH3:19])[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)-[c:26]1[cH:27][cH:28][n:29]([n:30]1)C1CCCCO1>Cl>[CH3:18][c:9]1[c:10]([c:11]([c:12]([c:6]2[CH2:5][C:4]([O:8][c:7]12)([CH3:19])[CH2:3][N:2]([CH3:1])[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)-[c:26]1[cH:27][cH:28][n:29][nH:30]1)[CH3:13])[N+:14]([O-:15])=[O:16])[CH3:17]|US08536169B2_0400
1.6.4|[C:5]-[N&H1&+0&D2:4]-[S:3].[O:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4](-[S:3])-[C&H2&+0&D2:1]-[O:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([n:6][c:7]([n:8]1)[CH:9]([C:10](=[O:11])[NH:12][S:13]([CH3:14])(=[O:15])=[O:16])[CH:17]([CH3:18])[CH3:19])[O:20][CH3:21].[CH3:22][O:23][CH2:24]Cl>O.CN(C)C=O.[NaH]>[CH3:22][O:23][CH2:24][N:12]([C:10](=[O:11])[CH:9]([c:7]1[n:8][c:3]([cH:4][c:5]([n:6]1)[O:20][CH3:21])[O:2][CH3:1])[CH:17]([CH3:18])[CH3:19])[S:13]([CH3:14])(=[O:15])=[O:16]|US20190071431A1_0727
1.8.19|[c:5]-[S&H0&+0&D2:4]-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[c:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([o:7]1)=[O:8])[OH:9].Cl[S:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>c1ccccc1.Cl[Na].[Na]>[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([o:7]1)=[O:8])[S:10][c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1)[OH:9]|US20090192190A1_0494
1.6.2|[O:5]-[C&H2&+0&D2:4]-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[O:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][CH2:3]Br.[CH3:4][n:5]1[nH:6][c:7]([n:8]([c:9]1=[S:10])-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17])=[O:18]>CN(C)C=O.ClCCl.[NaH]>[CH3:1][O:2][CH2:3][n:6]1[c:7]([n:8]([c:9]([n:5]1[CH3:4])=[S:10])-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17])=[O:18]|US20120277224A1_0556
1.6.2|[S:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[S:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[S:2]1([CH2:3][O:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[NH:11]1)[F:12])=[O:13].Br[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CCCC[N+](CCCC)(CCCC)CCCC.CCOC(C)=O.CN(C)C=O.[Br-]>[O:1]=[S:2]1([CH2:3][O:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[N:11]1[CH2:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1)[F:12])=[O:13]|US20200172483A1_0377
1.6.4|[O:5]-[C&H2&+0&D2:4]-Cl.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[O:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][O:2][CH2:3]Cl.[CH3:4][O:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]2[S:12][c:13]3[n:14][cH:15][cH:16][n:17][c:18]3[NH:19][c:20]2[cH:21]1>CN(C)C=O.[NaH]>[CH3:4][O:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]2[S:12][c:13]3[n:14][cH:15][cH:16][n:17][c:18]3[N:19]([c:20]2[cH:21]1)[CH2:3][O:2][CH3:1]|US10532053B2_0496
1.6.4|[O:5]-[C&H2&+0&D2:4]-Cl.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[O:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6]Cl.[CH3:7][c:8]1[n:9][o:10][c:11]([c:12]1[CH3:13])[NH:14][S:15](=[O:16])(=[O:17])[c:18]1[cH:19][cH:20][c:21]([s:22]1)[Br:23]>C1CCOC1.[NaH]>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][N:14]([c:11]1[o:10][n:9][c:8]([c:12]1[CH3:13])[CH3:7])[S:15](=[O:16])(=[O:17])[c:18]1[cH:19][cH:20][c:21]([s:22]1)[Br:23]|EP3097101B1_0057
1.6.4|[C:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[CH2:4][CH2:5]Cl.[cH:6]1[cH:7][nH:8][cH:9][n:10]1.[Ag]>Cc1ccccc1C>[CH3:1][C:2](=[O:3])[CH2:4][CH2:5][n:8]1[cH:9][n:10][cH:6][cH:7]1|US08969349B2_0508
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H1&+0&D2:2]-[O:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[O:1]|[CH3:1][CH:2]1[NH:3][O:4][CH2:5][CH2:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21.[CH3:13][CH2:14][CH2:15][CH2:16]Br>CCOCC.O=C(O[Na])O[Na]>[CH3:13][CH2:14][CH2:15][CH2:16][N:3]1[O:4][CH2:5][CH2:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[CH:2]1[CH3:1]|US20100152188A1_0183
1.6.4|[N:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[N:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][n:3]1[n:4][cH:5][c:6]2[c:7]1[n:8][cH:9][c:10]1[c:11]([n:12]3[n:13][cH:14][cH:15][c:16]3[nH:17][c:18]21)=[O:19].Cl[CH2:20][N:21]1[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]1>>[CH3:1][CH2:2][n:3]1[n:4][cH:5][c:6]2[c:18]3[c:10]([cH:9][n:8][c:7]21)[c:11]([n:12]1[n:13][cH:14][cH:15][c:16]1[n:17]3[CH2:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)=[O:19]|US20100222326A1_0538
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH2:1]=[CH:2][CH2:3]Br.[O:4]=[c:5]1[cH:6][cH:7][s:8][c:9]2[c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[nH:16][c:17]12>>[CH2:1]=[CH:2][CH2:3][n:16]1[c:17]2[c:9]([s:8][cH:7][cH:6][c:5]2=[O:4])[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21|US20160264552A1_0284
1.7.11|[C:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][c:2]1[cH:3][s:4][c:5]2[c:6]([c:7]([c:8]3[cH:9][c:10]([c:11]([cH:12][c:13]3[n:14]21)F)[F:15])=[O:16])[C:17](=[O:18])[OH:19].[CH3:20][CH2:21][O-:22]>CCO>[CH3:1][c:2]1[cH:3][s:4][c:5]2[c:6]([c:7]([c:8]3[cH:9][c:10]([c:11]([cH:12][c:13]3[n:14]12)[O:22][CH2:21][CH3:20])[F:15])=[O:16])[C:17](=[O:18])[OH:19]|US20190127358A1_1282
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|[Cl:1][CH2:2][CH2:3][CH2:4]Br.[cH:5]1[cH:6][cH:7][c:8]2[CH2:9][CH2:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3[NH:17][c:18]2[cH:19]1>CCCCCC.Cc1ccccc1.CCOCC.CCCC[Li]>[Cl:1][CH2:2][CH2:3][CH2:4][N:17]1[c:18]2[cH:19][cH:5][cH:6][cH:7][c:8]2[CH2:9][CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21|US20200190066A1_0277
1.6.4|[C:5]-[C&H2&+0&D2:4]-Cl.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[F:9])[CH:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1.Cl[CH2:16][CH2:17][CH2:18][N:19]1[c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[CH2:26][CH2:27][c:28]2[cH:29][cH:30][cH:31][cH:32][c:33]21>O.O.CC(C)O.CN(C)C=O.O=C(O)C(=O)O.O=C(O[K])O[K]>[O:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[F:9])[CH:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[CH2:16][CH2:17][CH2:18][N:19]1[c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[CH2:26][CH2:27][c:28]2[cH:29][cH:30][cH:31][cH:32][c:33]21|US05633265A
1.2.8|[N&H4&+&D0:4].[C&H3&D1:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H2&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[c:1]|[NH4+:1].[ClH:2].[CH3:3][C:4](=O)[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[O-]C=O>O>[ClH:2].[CH3:3][CH:4]([NH2:1])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US20200325124A1_0478
1.6.4|[c:5]-[C&H2&+0&D2:4]-Cl.[n:3]:[n&H1&+0&D2:2]:[n:1]>>[c:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][c:2]1[o:3][n:4][c:5]([c:6]1[CH2:7]Cl)[CH3:8].[NH2:9][c:10]1[n:11][n:12][nH:13][n:14]1>CN(C)C=O.O=C(O[K])O[K].ClCCl>[CH3:1][c:2]1[o:3][n:4][c:5]([c:6]1[CH2:7][n:13]1[n:12][n:11][c:10]([n:14]1)[NH2:9])[CH3:8]|EP3194374B1_0095
3.10.2|[c:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[c:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[CH2:8]Cl.[cH:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>O=P(O)(O)O.FB(F)F>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[CH2:8][c:12]1[cH:13][cH:14][cH:9][cH:10][cH:11]1|US20200361849A1_0280
3.10.2|[c:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[c:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[CH2:8]Br.[cH:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>O=P(O)(O)O.FB(F)F>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[CH2:8][c:12]1[cH:13][cH:14][cH:9][cH:10][cH:11]1|US05929097A
1.6.4|[S:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[S:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[NH:12][S:13]([CH3:14])(=[O:15])=[O:16].Cl[CH2:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[Cl:24]>O.CN(C)C=O.O=C(O[K])O[K].ClCCl>[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[N:12]([CH2:17][c:18]1[cH:23][cH:22][c:21]([cH:20][cH:19]1)[Cl:24])[S:13]([CH3:14])(=[O:15])=[O:16]|US20200360384A1_0097
1.6.4|[C:5]-[N&H1&+0&D2:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[C:2]1[NH:3][CH2:4][CH2:5][NH:6]1.Cl[CH2:7][c:8]1[cH:9][cH:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[cH:17]1>O.CS(C)=O.[O-]C([O-])=O.[K+].[K+]>[O:1]=[C:2]1[NH:6][CH2:5][CH2:4][N:3]1[CH2:7][c:8]1[cH:9][cH:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[cH:17]1|US07064120B2_0247
1.6.2|[C:5]-[N&H1&+0&D2:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[C:2]1[NH:3][CH2:4][CH2:5][NH:6]1.Br[CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Br:14]>O.CS(C)=O.[O-]C([O-])=O.[K+].[K+]>[O:1]=[C:2]1[NH:6][CH2:5][CH2:4][N:3]1[CH2:7][c:8]1[cH:13][cH:12][c:11]([cH:10][cH:9]1)[Br:14]|US05556860A
1.6.4|[C:5]-[C&H2&+0&D2:4]-Cl.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][c:10]2[S:11][c:12]3[cH:13][c:14]([cH:15][cH:16][c:17]3[NH:18][c:19]2[cH:20]1)[F:21].[CH3:22][N:23]1[CH2:24][CH2:25][N:26]([CH2:27][CH2:28]1)[CH2:29][CH2:30][CH2:31]Cl>CN(C)C=O.[NaH]>[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][c:10]2[S:11][c:12]3[cH:13][c:14]([cH:15][cH:16][c:17]3[N:18]([c:19]2[cH:20]1)[CH2:31][CH2:30][CH2:29][N:26]1[CH2:27][CH2:28][N:23]([CH2:24][CH2:25]1)[CH3:22])[F:21]|EP2992053B1_0163
1.6.4|[S:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[S:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][S:2][CH2:3]Cl.[CH3:4][c:5]1[cH:6][c:7]2[nH:8][c:9]([c:10]3[cH:11][n:12][c:13]4[nH:14][n:15][cH:16][c:17]4[c:18]3[n:19]2[n:20]1)=[O:21]>CCn1ncc2c3c(cnc21)c([nH]c1cc(nn13)C)=O.CN(C)CCCCl>[CH3:1][S:2][CH2:3][n:8]1[c:9]([c:10]2[cH:11][n:12][c:13]3[nH:14][n:15][cH:16][c:17]3[c:18]2[n:19]2[n:20][c:5]([cH:6][c:7]12)[CH3:4])=[O:21]|US20190263794A1_1531
1.6.4|[c:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[c:8]1[n:9][cH:10][c:11]2[c:12]([c:13]([cH:14][nH:15][c:16]2[n:17]1)[C:18](=[O:19])[OH:20])=[O:21].Cl[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>CN(C)C=O.O=C(O[K])O[K]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[c:8]1[n:9][cH:10][c:11]2[c:12]([c:13]([cH:14][n:15]([c:16]2[n:17]1)[CH2:22][c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1)[C:18](=[O:19])[OH:20])=[O:21]|US07338973B2_0705
1.6.4|[O:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[O:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[C:5](=[O:6])[c:7]1[cH:8][cH:9][cH:10][nH:11]1.Cl[CH2:12][O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>COCCOCCOC.[NaH]>[CH3:1][O:2][C:3](=[O:4])[C:5](=[O:6])[c:7]1[cH:8][cH:9][cH:10][n:11]1[CH2:12][O:13][CH2:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|US20180099966A1_0247
1.6.4|[C:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][N:4]([CH2:5][CH2:6][CH3:7])[CH2:8][C:9](=[O:10])[N:11]1[c:12]2[n:13][cH:14][cH:15][cH:16][c:17]2-[c:18]2[n:19][nH:20][c:21]([n:22]2-[c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]21)=[O:29].[CH3:30][N:31]([CH3:32])[CH2:33][CH2:34]Cl>Cc1ccccc1C.CN(C)C=O.[NaH]>[CH3:1][CH2:2][CH2:3][N:4]([CH2:5][CH2:6][CH3:7])[CH2:8][C:9](=[O:10])[N:11]1[c:28]2[cH:27][cH:26][cH:25][cH:24][c:23]2-[n:22]2[c:18]([n:19][n:20]([c:21]2=[O:29])[CH2:34][CH2:33][N:31]([CH3:30])[CH3:32])-[c:17]2[cH:16][cH:15][cH:14][n:13][c:12]21|US08658646B2_2068
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]1([CH2:3][CH:4]([CH2:5][C:6]([NH:7]1)([CH3:8])[CH3:9])[OH:10])[CH3:11].[CH3:12][CH2:13][CH2:14][CH2:15]Br>>[CH3:1][C:2]1([CH2:3][CH:4]([CH2:5][C:6]([N:7]1[CH2:15][CH2:14][CH2:13][CH3:12])([CH3:8])[CH3:9])[OH:10])[CH3:11]|EP1994019B1_0059
3.11.91|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[C&H2&+0&D2:2]-[n:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH2:7][n:8]1[cH:9][n:10][cH:11][n:12]1.Br[CH2:13][CH2:14][CH2:15][CH2:16][O:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>CC(C)OC(C)C.CN(C)C=O.O.[NaH]>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH:7]([CH2:13][CH2:14][CH2:15][CH2:16][O:17][c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1)[n:8]1[cH:9][n:10][cH:11][n:12]1|US20180250280A1_0705
3.11.91|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[C&H2&+0&D2:2]-[O:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O:1]|[O:1]=[C:2]([OH:3])[CH2:4][O:5][c:6]1[cH:7][cH:8][cH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]12.Br[CH2:16][CH2:17][CH2:18][CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>CC(C)NC(C)C.CCCCCC.CCCC[Li].C1CCOC1.[NaH]>[O:1]=[C:2]([OH:3])[CH:4]([CH2:16][CH2:17][CH2:18][CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[O:5][c:6]1[cH:7][cH:8][cH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21|US20160002185A1_1681
3.11.91|[C:5]-[C&H2&+0&D2:4]-Cl.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][C:2](=[O:3])[CH2:4][c:5]1[cH:6][cH:7][c:8]2[O:9][c:10]3[n:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][c:17]2[cH:18]1.[CH3:19][N:20]([CH3:21])[CH2:22][CH2:23]Cl>O.CC(C)O.[Na]>[CH3:1][C:2](=[O:3])[CH:4]([CH2:23][CH2:22][N:20]([CH3:19])[CH3:21])[c:5]1[cH:6][cH:7][c:8]2[O:9][c:10]3[n:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][c:17]2[cH:18]1|EP0529973A1_0078
1.7.11|[C:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Na+].[O-:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[O:9]=[S:10](=[O:11])([c:12]1[cH:13][cH:14][cH:15][c:16]([n:17]1)F)[N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1>O.CN(C)C=O>[O:9]=[S:10](=[O:11])([c:12]1[cH:13][cH:14][cH:15][c:16]([n:17]1)[O:1][CH2:2][c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1)[N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1|US20170333406A1_0471
1.6.4|[C:5]-[N&H1&+0&D2:4]-[S:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4](-[S:3])-[C&H2&+0&D2:1]-[c:2]|Cl.[O:1]=[S:2]1([CH2:3][CH2:4][CH2:5][NH:6]1)=[O:7].Cl[CH2:8][c:9]1[cH:10][cH:11][n:12][cH:13][cH:14]1>O.O[Na]>[O:1]=[S:2]1([CH2:3][CH2:4][CH2:5][N:6]1[CH2:8][c:9]1[cH:14][cH:13][n:12][cH:11][cH:10]1)=[O:7]|US20200055874A1_2783
3.11.91|[C:5]-[C&H2&+0&D2:4]-[C:3].[O:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[O:2]|[CH3:1][O:2][C:3]([O:4][CH3:5])([O:6][CH3:7])[C:8](=[O:9])[CH2:10][CH2:11][C:12](=[O:13])[O:14][CH3:15].[CH3:16][O:17][CH2:18]Cl>CN(C)P(=O)(N(C)C)N(C)C.CC(C)NC(C)C.C1CCOC1.[NH4+].[Cl-]>[CH3:16][O:17][CH2:18][CH:11]([CH2:10][C:8](=[O:9])[C:3]([O:4][CH3:5])([O:6][CH3:7])[O:2][CH3:1])[C:12](=[O:13])[O:14][CH3:15]|US20170369444A1_0240
1.6.2|[c:5]-[C&H2&+0&D2:4]-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH2:1]=[CH:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([c:8]2[c:9]1[o:10][c:11]([cH:12][c:13]2=[O:14])-[c:15]1[n:16][n:17][n:18][nH:19]1)[O:20][CH2:21][CH2:22][CH:23]([CH3:24])[CH3:25].Br[CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>O.CCO.O[Na]>[CH2:1]=[CH:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([c:8]2[c:13]([cH:12][c:11]([o:10][c:9]12)-[c:15]1[n:16][n:17][n:18][n:19]1[CH2:26][c:27]1[cH:32][cH:31][cH:30][cH:29][cH:28]1)=[O:14])[O:20][CH2:21][CH2:22][CH:23]([CH3:24])[CH3:25]|US07259266B2_1867
1.6.2|[C:5]-[N&H1&+0&D2:4]-[O:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[N&H0&+0&D3:4](-[O:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2]1([CH2:3][O:4][NH:5][C:6]1=[O:7])[CH3:8].[F:9][c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[Cl:16])[CH2:17]Br>CCCCCC.CN(C)C=O.O=C(O[K])O[K]>[CH3:1][C:2]1([CH2:3][O:4][N:5]([C:6]1=[O:7])[CH2:17][c:13]1[cH:12][cH:11][c:10]([cH:15][c:14]1[Cl:16])[F:9])[CH3:8]|EP3362447B1_0051
1.2.9|[C:5]-[N&H1&+0&D2:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-O>>[C:5]-[N&H0&+0&D3:4]1-[C&H2&+0&D2:1]-[C:2]-[C:3]-1|O[CH2:1][CH:2]([CH2:3][OH:4])[CH2:5][NH:6][CH2:7][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCN(CC)CC.ClC(Cl)(Cl)Cl>[OH:4][CH2:3][CH:2]1[CH2:1][N:6]([CH2:5]1)[CH2:7][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1|US20190270741A1_0658
3.11.91|[C:5]-[C&H2&+0&D2:4]-[S:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[C&H1&+0&D3:4](-[S:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][S:7]([CH3:8])(=[O:9])=[O:10].Br[CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>CN(C)C=O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH2:11][c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1)[S:7]([CH3:8])(=[O:9])=[O:10]|US20110105544A1_0702
1.6.4|[C:5]-[N&H1&+0&D2:4]-[S:3].[S:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4](-[S:3])-[C&H2&+0&D2:1]-[S:2]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[C:8]([NH:9][S:10]2(=[O:11])=[O:12])=[O:13].Cl[CH2:14][S:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.CCOC(C)=O.[Br-]>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[C:8]([N:9]([S:10]2(=[O:11])=[O:12])[CH2:14][S:15][c:16]1[cH:21][cH:20][cH:19][cH:18][cH:17]1)=[O:13]|US05512576A
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H1&+0&D2:2]-[N:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[N:1]|[CH2:1]=[CH:2][CH2:3]Br.[CH3:4][S:5][C:6](=[N:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[NH:14][N:15]1[C:16]([c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[C:23]1=[O:24])=[O:25]>O.CC(C)=O.O=C(O[K])O[K]>[CH2:1]=[CH:2][CH2:3][N:14]([C:6](=[N:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[S:5][CH3:4])[N:15]1[C:23]([c:22]2[cH:21][cH:20][cH:19][cH:18][c:17]2[C:16]1=[O:25])=[O:24]|US09840471B2_0428
1.8.14|[C:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][CH2:2][S-:3].[O:4]=[C:5]1[NH:6][c:7]2[cH:8][c:9]([c:10]([cH:11][c:12]2[C:13]1=[O:14])[F:15])F>CSc1cc2[nH]ccc2cc1F>[CH3:1][CH2:2][S:3][c:9]1[cH:8][c:7]2[NH:6][C:5]([C:13]([c:12]2[cH:11][c:10]1[F:15])=[O:14])=[O:4]|US08658636B2_0380
3.10.2|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([CH2:3]Br)[N:4]1[CH2:5][CH2:6][CH2:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]21>O.Cl[Al](Cl)Cl>[O:1]=[C:2]1[CH2:3][c:12]2[cH:11][cH:10][cH:9][c:8]3[CH2:7][CH2:6][CH2:5][N:4]1[c:13]23|US07732628B2_0353
1.6.4|[C:5]-[N&H1&+0&D2:4]-[N:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4](-[N:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[C:11]1[CH2:12][S:13][C:14]([NH:15][N:16]=1)=[O:17].[O-:18][N+:19](=[O:20])[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[CH2:27]Cl>>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[C:11]1[CH2:12][S:13][C:14]([N:15]([N:16]=1)[CH2:27][c:24]1[cH:25][cH:26][c:21]([cH:22][cH:23]1)[N+:19]([O-:18])=[O:20])=[O:17]|US20180206495A1_0218
1.6.2|[C:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]2[NH:8][C:9]([N:10]3[CH2:11][CH2:12][O:13][C:14]3([c:15]2[cH:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:23].Br[CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>[NaH]>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]2[c:15]([cH:16]1)[C:14]1([O:13][CH2:12][CH2:11][N:10]1[C:9]([N:8]2[CH2:24][c:25]1[cH:30][cH:29][cH:28][cH:27][cH:26]1)=[O:23])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US10344026B2_0281
1.6.4|[P:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[P:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][P:2]([CH3:3])(=[O:4])[CH2:5]Cl.[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][n:12]1[c:13]([n:14]([c:15]2[n:16][cH:17][nH:18][c:19]2[c:20]1=[O:21])[CH3:22])=[O:23].[Na]>>[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][n:12]1[c:13]([n:14]([c:15]2[n:16][cH:17][n:18]([c:19]2[c:20]1=[O:21])[CH2:5][P:2]([CH3:1])([CH3:3])=[O:4])[CH3:22])=[O:23]|EP0771813A1_0117
1.6.2|[O:5]-[C&H2&+0&D2:4]-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[O:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][CH2:7]Br.[Br:8][c:9]1[n:10][c:11]([nH:12][c:13]1[Br:14])[Br:15]>O.CN(C)C=O.[Na].[NaH]>[Br:8][c:9]1[n:10][c:11]([n:12]([c:13]1[Br:14])[CH2:7][O:6][CH2:5][CH2:4][CH2:3][CH2:2][Br:1])[Br:15]|US20200360357A1_0443
1.6.2|[C:5]-[N&H1&+0&D2:4]-[S:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[N&H0&+0&D3:4](-[S:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[C:5]1[NH:6][S:7]([c:8]2[c:9]([cH:10][cH:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]32)[C:18]=1[OH:19])(=[O:20])=[O:21].Br[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>O.CCO.O[Na]>[CH3:1][O:2][C:3](=[O:4])[C:5]1=[C:18]([c:9]2[cH:10][cH:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[c:8]2[S:7]([N:6]1[CH2:22][c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1)(=[O:20])=[O:21])[OH:19]|US08076491B2_0708
3.11.91|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[C&H2&+0&D2:2]-[P:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[P:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][P:7](=[O:8])([O:9][CH2:10][CH3:11])[O:12][CH2:13][CH3:14].[CH3:15][O:16][c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[Cl:23])[O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]Br>Cc1ccccc1C.[K]>[CH3:11][CH2:10][O:9][P:7](=[O:8])([O:12][CH2:13][CH3:14])[CH:6]([CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][O:24][c:20]1[cH:19][cH:18][c:17]([cH:22][c:21]1[Cl:23])[O:16][CH3:15])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20090203697A1_0429
1.6.2|[C:5]-[N&H1&+0&D2:4]-[N:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[N&H0&+0&D3:4](-[N:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][N:2]([NH:3][C:4](=[O:5])[O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[C:14](=[O:15])[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[N:24]#[C:25][c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[CH2:32]Br>CN(C)C=O.[H][H].[NaH]>[CH3:1][N:2]([C:14](=[O:15])[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[N:3]([CH2:32][c:29]1[cH:28][cH:27][c:26]([cH:31][cH:30]1)[C:25]#[N:24])[C:4](=[O:5])[O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US20150031861A1_0538
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[N:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[N:3])-[c:1]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[Cl:11])[C:12](=[O:13])[NH:14][NH:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[CH2:22]=[CH:23][CH2:24]Br>CN(C)P(=O)(N(C)C)N(C)C.CCOC(C)=O.O=C(O)O[Na]>[CH2:22]=[CH:23][CH2:24][N:15]([NH:14][C:12](=[O:13])[c:7]1[cH:8][cH:9][c:10]([c:5]([cH:6]1)[S:2]([NH2:1])(=[O:3])=[O:4])[Cl:11])[c:16]1[cH:21][cH:20][cH:19][cH:18][cH:17]1|EP3640253A1_0195
3.10.2|[c:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[c:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[n:10]1[n:11][n:12][c:13]([n:14]1)-[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1-[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[CH2:27]Br.[CH3:28][CH2:29][CH2:30][CH2:31][n:32]1[cH:33][c:34]([c:35]2[c:36]1[cH:37][cH:38][cH:39][cH:40]2)[C:41](=[O:42])[OH:43]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCOC(C)=O.CCCC[Li].C1CCOC1.Cl[Zn]Cl.O[Na]>[CH3:28][CH2:29][CH2:30][CH2:31][n:32]1[c:36]2[cH:37][cH:38][cH:39][cH:40][c:35]2[c:34]([c:33]1[CH2:27][c:24]1[cH:23][cH:22][c:21]([cH:26][cH:25]1)-[c:20]1[cH:19][cH:18][cH:17][cH:16][c:15]1-[c:13]1[n:12][n:11][n:10]([n:14]1)[C:2]([CH3:1])([CH3:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[C:41](=[O:42])[OH:43]|US05338734A
1.2.5|[N&H4&+&D0:4].[C&H3&D1:3]-[C&H0&+0&D3:2](-[C:1])=O>>[N&H2&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[C:1]|[NH4+:1].[CH3:2][C:3](=O)[CH2:4][CH2:5][n:6]1[cH:7][n:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21.CC([O-])=O>[Na+].CO.N#C[BH3-]>[CH3:2][CH:3]([NH2:1])[CH2:4][CH2:5][n:6]1[cH:7][n:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21|US20200331911A1_0551
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[O:1]=[C:2]1[CH2:3][N:4]2[CH2:5][CH2:6][O:7][C:8]2([c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[NH:15]1)[Cl:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[F:23].[OH:24][CH2:25][CH2:26]Br>O.Cl.CN(C)C=O.[NaH]>[O:1]=[C:2]1[CH2:3][N:4]2[CH2:5][CH2:6][O:7][C:8]2([c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[N:15]1[CH2:26][CH2:25][OH:24])[Cl:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[F:23]|EP3066094B1_0383
1.6.4|[C:5]-[N&H1&+0&D2:4]-[C:3].[O:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[O:2]|[CH3:1][O:2][CH2:3]Cl.[O:4]=[C:5]([NH:6][C:7](=[O:8])[c:9]1[c:10]([cH:11][cH:12][cH:13][c:14]1[Cl:15])[Cl:16])[NH:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[Cl:24]>O.CI.CN(C)C=O.O[K]>[CH3:1][O:2][CH2:3][N:6]([C:5](=[O:4])[NH:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[Cl:24])[C:7](=[O:8])[c:9]1[c:14]([cH:13][cH:12][cH:11][c:10]1[Cl:16])[Cl:15]|EP3590927A1_0220
1.6.4|[C:5]-[N&H1&+0&D2:4]-[c:3].[O:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[O:2]|[CH3:1][O:2][CH2:3]Cl.[O:4]=[C:5]1[CH2:6][N:7]2[CH2:8][CH2:9][O:10][C:11]2([c:12]2[cH:13][c:14]([cH:15][cH:16][c:17]2[NH:18]1)[Cl:19])[c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1[Cl:26]>[Na+].C[O-].CN(C)C=O>[CH3:1][O:2][CH2:3][N:18]1[C:5]([CH2:6][N:7]2[CH2:8][CH2:9][O:10][C:11]2([c:12]2[cH:13][c:14]([cH:15][cH:16][c:17]21)[Cl:19])[c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1[Cl:26])=[O:4]|EP3124487A1_0271
1.6.2|[N:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[N:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[NH:9][N:10]=[C:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.Br[CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>CN(C)C=O.[O-]C([O-])=O.[K+].[K+]>[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[N:9]([CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[N:10]=[C:11]([c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|EP3640253A1_0463
3.11.91|[C:5]-[C&H2&+0&D2:4]-[O:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[C&H1&+0&D3:4](-[O:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[C:2]1[CH2:3][O:4][CH2:5][CH2:6][N:7]1[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH3:15][C:16]([CH3:17])([CH3:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[CH2:25]Br>CC(C)N(C(C)C)[Li].C1CCOC1.[NH4+].O.[Cl-]>[CH3:15][C:16]([CH3:17])([CH3:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[CH2:25][CH:3]1[O:4][CH2:5][CH2:6][N:7]([C:2]1=[O:1])[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US20160002185A1_1420
1.7.9|[C:4]-[O&H1&+0&D1:3].[Cl&H0&D1:2]-[C&H2&+0&D2:1]-Cl>>[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:1]-[Cl&H0&D1:2]|[OH:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[Cl:9][CH2:10]Cl>Cl.C=O.[O-]S([O-])(=O)=O.[Mg+2]>[Cl:9][CH2:10][O:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|US20200255403A1_0309
3.11.91|[C:5]-[C&H2&+0&D2:4]-[N:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[C&H1&+0&D3:4](-[N:3])-[C&H2&+0&D2:1]-[c:2]|Cl[CH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH3:16][C:17]([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH2:24][CH2:25][NH:26][C:27]([CH2:28]1)=[O:29]>CC(C)NC(C)C.CCCCCC.CCCC[Li].C1CCOC1>[CH3:16][C:17]([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH2:24][CH2:25][NH:26][C:27]([CH:28]1[CH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][CH2:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1)=[O:29]|US10272074B2_1829
1.8.12|[Cl&H0&D1:4]-[C&H2&+0&D2:3]-Br.[S&H1&+0&D1:2]-[c:1]>>[Cl&H0&D1:4]-[C&H2&+0&D2:3]-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[S:6](=[O:7])(=[O:8])[c:9]1[cH:10][c:11]([c:12]([c:13]([c:14]1[SH:15])[Cl:16])[Cl:17])[Cl:18].[Cl:19][CH2:20]Br>CC[N+](Cc1ccccc1)(CC)CC.O[K].[Br-]>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[S:6](=[O:7])(=[O:8])[c:9]1[cH:10][c:11]([c:12]([c:13]([c:14]1[S:15][CH2:20][Cl:19])[Cl:16])[Cl:17])[Cl:18]|US20110224186A1_0273
1.6.4|[C:5]-[C&H2&+0&D2:4]-Cl.[n:3]:[n&H1&+0&D2:2]:[n:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[C:6]([CH2:7][CH2:8][N:9]1[CH2:10][CH2:11][C:12]([CH2:13][CH2:14]1)([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[n:22][n:23][nH:24][n:25]1)([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.[NH2:38][C:39](=[O:40])[CH2:41]Cl>>[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[C:6]([CH2:7][CH2:8][N:9]1[CH2:10][CH2:11][C:12]([CH2:13][CH2:14]1)([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[n:22][n:23][n:24]([n:25]1)[CH2:41][C:39]([NH2:38])=[O:40])([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1|US20050282812A1_0355
3.11.83|[C:5]-[C&H2&+0&D2:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([c:10]1[Br:11])[CH2:12]Br.[CH3:13][CH2:14][O:15][C:16](=[O:17])[CH2:18][C:19](=[O:20])[O:21][CH2:22][CH3:23].[Na]>>[CH3:23][CH2:22][O:21][C:19](=[O:20])[CH:18]([CH2:12][c:9]1[cH:8][cH:7][cH:6][c:5]([c:10]1[Br:11])[C:2]([F:1])([F:3])[F:4])[C:16](=[O:17])[O:15][CH2:14][CH3:13]|EP1660475B1_0136
3.11.52|[C:5]-[C&H2&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[N:1]#[C:2][CH2:3][c:4]1[cH:5][cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[cH:13]1.Br[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>[Na+].COCCOC.[H-]>[N:1]#[C:2][CH:3]([CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:4]1[cH:5][cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[cH:13]1|US20190119269A1_0546
1.7.9|[Cl&H0&D1:4]-[C&H2&+0&D2:3]-Br.[O&H1&+0&D1:2]-[c:1]>>[Cl&H0&D1:4]-[C&H2&+0&D2:3]-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][cH:7][c:8]([c:9]1[OH:10])[CH:11]([CH3:12])[CH3:13].[Cl:14][CH2:15]Br>C1CCOC1.O[Na]>[CH3:12][CH:11]([CH3:13])[c:8]1[cH:7][cH:6][cH:5][c:4]([c:9]1[O:10][CH2:15][Cl:14])[CH:2]([CH3:1])[CH3:3]|US09517988B2_0728
1.6.4|[C:5]-[C&H2&+0&D2:4]-Cl.[C:3]-[N&H1&+0&D2:2]-[S:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[S:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5]Cl.[O:6]=[C:7]1[NH:8][S:9]([c:10]2[c:11]1[cH:12][cH:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]12)(=[O:20])=[O:21]>CO.[Na]>[CH3:1][O:2][C:3](=[O:4])[CH2:5][N:8]1[C:7]([c:11]2[cH:12][cH:13][c:14]3[cH:15][cH:16][cH:17][cH:18][c:19]3[c:10]2[S:9]1(=[O:20])=[O:21])=[O:6]|US07655641B2_0862
1.6.4|[C:5]-[C&H2&+0&D2:4]-Cl.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH2:1]=[C:2]([CH3:3])[CH2:4]Cl.[O:5]=[C:6]1[CH2:7][C:8]([N:9]([c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[NH:16]1)[Cl:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)=[O:24]>[Br-]>[CH2:1]=[C:2]([CH3:3])[CH2:4][N:16]1[C:6]([CH2:7][C:8]([N:9]([c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]21)[Cl:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)=[O:24])=[O:5]|US05696117A
1.6.4|[C:5]-[C&H2&+0&D2:4]-Cl.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH2:7]Cl.[CH3:8][S:9](=[O:10])(=[O:11])[NH:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[C:19](=[O:20])[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>CC#N.O=C(O[K])O[K]>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH2:7][N:12]([c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[C:19](=[O:20])[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[S:9]([CH3:8])(=[O:10])=[O:11]|US20120094964A1_0547
1.6.2|[c:5]-[C&H2&+0&D2:4]-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)-[n:10]1[c:11]2[n:12][cH:13][cH:14][cH:15][c:16]2[c:17]([nH:18][c:19]1=[O:20])=[O:21].Br[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>CN(C)C=O.[NaH]>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)-[n:10]1[c:19]([n:18]([c:17]([c:16]2[cH:15][cH:14][cH:13][n:12][c:11]21)=[O:21])[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)=[O:20]|EP0526001A1_0089
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3]Br.[CH3:4][CH2:5][CH2:6][CH2:7][NH:8][c:9]1[cH:10][cH:11][c:12]2[n:13][nH:14][c:15]([n:16]2[n:17]1)=[O:18]>>[CH3:4][CH2:5][CH2:6][CH2:7][NH:8][c:9]1[cH:10][cH:11][c:12]2[n:13][n:14]([c:15]([n:16]2[n:17]1)=[O:18])[CH2:3][CH2:2][CH3:1]|US08071581B2_0616
1.6.2|[c:5]-[C&H2&+0&D2:4]-Br.[c:3]-[N&H1&+0&D2:2]-[n:1]>>[c:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[n:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[NH:10][n:11]1[cH:12][n:13][n:14][cH:15]1.Br[CH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Br:23]>CC#N.O=C(O[K])O[K]>[O-:1][N+:2](=[O:3])[c:4]1[cH:9][cH:8][c:7]([cH:6][cH:5]1)[N:10]([CH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Br:23])[n:11]1[cH:12][n:13][n:14][cH:15]1|EP0641785A1_0158
1.6.4|[c:5]-[C&H2&+0&D2:4]-Cl.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|Cl[CH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[cH:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[NH:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O.c1ccc(cc1)OCc1ccccc1>[cH:8]1[cH:13][cH:12][c:11]([cH:10][cH:9]1)[N:14]([CH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|EP0640595A1_0080
1.6.4|[c:5]-[C&H2&+0&D2:4]-Cl.[c:3]-[N&H1&+0&D2:2]-[n:1]>>[c:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[n:1]|[CH3:1][n:2]1[n:3][n:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[CH2:11]Cl.[O-:12][N+:13](=[O:14])[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[NH:21][n:22]1[cH:23][n:24][n:25][cH:26]1>>[CH3:1][n:2]1[n:3][n:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[CH2:11][N:21]([c:18]1[cH:19][cH:20][c:15]([cH:16][cH:17]1)[N+:13]([O-:12])=[O:14])[n:22]1[cH:23][n:24][n:25][cH:26]1|EP0641785A1_0156
7.6.1|[C:5]-[C&H0&+0&D3:4]1=[C&H1&+0&D2:3]-[C:2]-[C:1]-1>>[C:5]-[C&H1&+0&D3:4]1-[C&H2&+0&D2:3]-[C:2]-[C:1]-1|[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][CH:6]1[CH:7]=[C:8]([CH2:9]1)[C:10](=[O:11])[OH:12]>>[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][CH:6]1[CH2:9][CH:8]([CH2:7]1)[C:10](=[O:11])[OH:12]|US08906889B2_0586
1.7.9|[C:5]-[C&H1&+0&D3:4](-[C:3])-Br.[C:2]-[O&H0&-&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:1]-[C:2]|[Na+].[CH3:1][CH2:2][O-:3].[CH3:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18](Br)[C:19](=[O:20])[O:21][CH2:22][CH3:23]>O.CCOCC.CCO.[Na]>[CH3:23][CH2:22][O:21][C:19](=[O:20])[CH:18]([CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH3:4])[O:3][CH2:2][CH3:1]|US20060014702A1_0094
1.2.9|[C:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-O>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][n:6][n:7]2[c:8]1[n:9][c:10]([n:11][c:12]2O)[O:13][CH:14]1[CH2:15][CH2:16][N:17]([CH2:18][CH2:19]1)[CH3:20].[CH3:21][C:22]([CH3:23])([CH3:24])[O:25][C:26](=[O:27])[N:28]1[CH2:29][CH2:30][CH:31]([CH2:32][CH2:33]1)[NH2:34]>>[CH3:21][C:22]([CH3:23])([CH3:24])[O:25][C:26](=[O:27])[N:28]1[CH2:29][CH2:30][CH:31]([CH2:32][CH2:33]1)[NH:34][c:12]1[n:11][c:10]([n:9][c:8]2[c:4]([cH:5][n:6][n:7]21)[CH:2]([CH3:1])[CH3:3])[O:13][CH:14]1[CH2:15][CH2:16][N:17]([CH2:18][CH2:19]1)[CH3:20]|US10457669B2_2335
1.3.7|[C:5]-[N&H3&+&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Cl-].[CH3:1][C@@H:2]1[O:3][CH2:4][C:5]([C@H:6]1[NH:7][C:8](=[O:9])[C@@H:10]([NH3+:11])[CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)=[O:19].[O:20]=[c:21]1[n:22][c:23]([c:24]2[cH:25][cH:26][cH:27][cH:28][c:29]2[o:30]1)Cl>CC(C)N(CC)C(C)C.CC#N>[CH3:1][C@@H:2]1[O:3][CH2:4][C:5]([C@H:6]1[NH:7][C:8](=[O:9])[C@H:10]([CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[NH:11][c:23]1[n:22][c:21]([o:30][c:29]2[cH:28][cH:27][cH:26][cH:25][c:24]12)=[O:20])=[O:19]|US09604937B2_1301
1.2.5|[N&H3&+0&D0:4].[C&H3&D1:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H2&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[c:1]|[NH3:1].[CH3:2][C:3](=O)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10](=[O:11])[OH:12]>[Ni]>[CH3:2][CH:3]([NH2:1])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10](=[O:11])[OH:12]|EP3660016A1_0600
1.8.14|[C:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)F.[SH:10][CH2:11][CH2:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>O.CN(C)C=O.O=C(O[K])O[K]>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[S:10][CH2:11][CH2:12][CH2:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|EP3753941A1_0718
2.6.9|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-O>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][c:7]1[cH:8][c:9]2[c:10]([cH:11][c:12]1[C:13](=[O:14])[OH:15])[C:16]([CH2:17][CH2:18][C:19]2([CH3:20])[CH3:21])([CH3:22])[CH3:23].[O:24]=[C:25]([O:26][CH2:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)[c:34]1[cH:35][n:36][c:37]([cH:38][cH:39]1)O>CN(C)c1ccncc1.ClCCl.C(=NC1CCCCC1)=NC1CCCCC1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][c:7]1[cH:8][c:9]2[c:10]([cH:11][c:12]1[C:13](=[O:14])[O:15][c:37]1[cH:38][cH:39][c:34]([cH:35][n:36]1)[C:25](=[O:24])[O:26][CH2:27][c:28]1[cH:33][cH:32][cH:31][cH:30][cH:29]1)[C:16]([CH2:17][CH2:18][C:19]2([CH3:20])[CH3:21])([CH3:22])[CH3:23]|US07659245B2_0657
1.3.9|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH2:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)I)[C:9]([OH:10])([CH2:11][n:12]1[cH:13][n:14][cH:15][n:16]1)[c:17]1[cH:18][cH:19][c:20]([cH:21][c:22]1[F:23])[F:24].[NH2:25][CH:26]=[O:27]>O.[Na+].[Na+].[O-]C(=O)CN(CCN(CC(=O)O)CC(=O)O)CC([O-])=O.O=C(O[K])O[K].[Cu]>[CH2:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:25][CH:26]=[O:27])[C:9]([OH:10])([CH2:11][n:12]1[cH:13][n:14][cH:15][n:16]1)[c:17]1[cH:18][cH:19][c:20]([cH:21][c:22]1[F:23])[F:24]|US09790230B2_0294
9.7.33|[N&H3&+0&D0:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][c:8]([cH:9][c:10]([c:11]1[O:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[S:19]([NH2:20])(=[O:21])=[O:22])[C:23](=[O:24])O.[NH3:25]>CCN(CC)CC.CS(=O)(=O)Cl.CC(C)=O>[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][c:8]([cH:9][c:10]([c:11]1[O:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[S:19]([NH2:20])(=[O:21])=[O:22])[C:23]([NH2:25])=[O:24]|US10428026B2_2131
1.8.14|[C:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][S:4][c:5]1[cH:6][cH:7][cH:8][n:9][c:10]1F.[SH:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>O.CN(C)C=O.[NaH]>[CH3:1][CH2:2][CH2:3][S:4][c:5]1[cH:6][cH:7][cH:8][n:9][c:10]1[S:11][CH2:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|EP3013796B9_0613
1.2.5|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[ClH:1].[CH3:2][c:3]1[cH:4][c:5]([c:6]2[CH2:7][CH2:8][C:9]([c:10]2[c:11]1[OH:12])=O)[CH3:13].[CH3:14][CH2:15][CH2:16][CH2:17][NH2:18]>O.[Na+].[Na+].CCO.CC([O-])=O.[BH4-]>[ClH:1].[CH3:14][CH2:15][CH2:16][CH2:17][NH:18][CH:9]1[CH2:8][CH2:7][c:6]2[c:5]([cH:4][c:3]([c:11]([c:10]21)[OH:12])[CH3:2])[CH3:13]|US20080207634A1_0155
7.6.1|[c:5]-[C&H0&+0&D3:4]1=[C&H1&+0&D2:3]-[C:2]-[C:1]-1>>[c:5]-[C&H1&+0&D3:4]1-[C&H2&+0&D2:3]-[C:2]-[C:1]-1|[CH3:1][CH:2]([CH3:3])[CH2:4][NH:5][C:6](=[O:7])[CH:8]1[CH:9]=[C:10]([CH2:11]1)[c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[F:18])[CH2:19][N:20]1[CH2:21][CH2:22][CH2:23][CH2:24]1>CCO.CCOC(C)=O.[H][H].[Pd]>[CH3:1][CH:2]([CH3:3])[CH2:4][NH:5][C:6](=[O:7])[CH:8]1[CH2:9][CH:10]([CH2:11]1)[c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[F:18])[CH2:19][N:20]1[CH2:21][CH2:22][CH2:23][CH2:24]1|US20190127362A1_0970
1.6.2|[c:5]-[N&H1&+0&D2:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-Br>>[c:5]-[N&H0&+0&D3:4]1-[C&H2&+0&D2:1]-[C:2]-[C:3]-1|[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[NH:12][C:13](=[O:14])[CH2:15][CH2:16]Br>CN(C)C=O.C1CCOC1.[NaH]>[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N:12]1[CH2:16][CH2:15][C:13]1=[O:14]|EP2914594B1_0434
1.2.3|[C:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C:5]/[C&H0&+0&D3:4](=[N&H0&+0&D2:2]\[c:1])-[c:3]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[C:8]([F:9])([F:10])[F:11].[O:12]=[C:13]1[NH:14][c:15]2[cH:16][cH:17][c:18]([cH:19][c:20]2[C:21]1=O)[Br:22]>CO.CC(=O)O>[O:12]=[C:13]1[NH:14][c:15]2[cH:16][cH:17][c:18]([cH:19][c:20]2/[C:21]1=[N:1]/[c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[C:8]([F:9])([F:10])[F:11])[Br:22]|US10807997B2_0344
1.7.11|[C:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][CH2:2][CH2:3][O-:4].[O:5]=[C:6]1[c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[CH2:13][CH2:14][c:15]2[c:16]1[n:17][c:18]1[c:19]([cH:20][n:21][n:22]1[CH2:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[c:30]2Br>>[CH3:1][CH2:2][CH2:3][O:4][c:30]1[c:19]2[cH:20][n:21][n:22]([c:18]2[n:17][c:16]2[C:6]([c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[CH2:13][CH2:14][c:15]21)=[O:5])[CH2:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1|US20160199372A1_0177
2.1.18|[C:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H1&+0&D2:1]-[O&-]>>[C:4]-[N&H1&+0&D2:3]-[C&H1&+0&D2:1]=[O&H0&D1:2]|[Na+].[NH2:1][CH2:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1.[O-][CH:19]=[O:20]>O=CO>[O:20]=[CH:19][NH:1][CH2:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1|EP0333174B1_0227
1.6.4|[c:5]-[N&H1&+0&D2:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-Cl>>[c:5]-[N&H0&+0&D3:4]1-[C&H2&+0&D2:1]-[C:2]-[C:3]-1|[CH2:1]=[CH:2][CH2:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[NH:10][C:11](=[O:12])[CH2:13][CH2:14]Cl>c1ccccc1.ClC(Cl)(Cl)Cl.[NaH]>[CH2:1]=[CH:2][CH2:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[N:10]1[CH2:14][CH2:13][C:11]1=[O:12]|EP2558457B1_0419
1.7.7|[C:5]-[C&H1&+0&D3:4](-[c:3])-O.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|O[CH:1]([c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[Cl:8])[C:9]([Cl:10])([Cl:11])[Cl:12].[OH:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20]>O=S(=O)(O)O>[Cl:8][c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH:1]([O:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20])[C:9]([Cl:10])([Cl:11])[Cl:12]|US08247576B2_0790
1.6.8|[C:5]=[N&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|I[c:1]1[cH:2][c:3]([cH:4][c:5]2[n:6]1[n:7][cH:8][cH:9]2)-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[NH:16]=[C:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>c1ccc(cc1)P(c1ccccc1)c1ccc2ccccc2c1-c1c2ccccc2ccc1P(c1ccccc1)c1ccccc1.Cc1ccccc1.O=C(O[Cs])O[Cs].CC([O-])=O.CC([O-])=O.[Pd+2]>[cH:13]1[cH:12][cH:11][c:10]([cH:15][cH:14]1)-[c:3]1[cH:4][c:5]2[cH:9][cH:8][n:7][n:6]2[c:1]([cH:2]1)[N:16]=[C:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:29][cH:28][cH:27][cH:26][cH:25]1|US20190062313A1_0416
1.2.3|[C:5]-[C&H0&+0&D3:4](-[N:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[c:1])-[N:3]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[C:8]([F:9])([F:10])[F:11])[Br:12].[CH3:13][NH:14][C:15](=O)[C:16]([CH3:17])([CH3:18])[O:19][C:20]([CH3:21])=[O:22]>CC[O+](CC)CC.F[B-](F)(F)F.F[B-](F)(F)F.CCO.ClCCl.Cl>[CH3:13][NH:14][C:15](=[N:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[C:8]([F:9])([F:10])[F:11])[Br:12])[C:16]([CH3:17])([CH3:18])[O:19][C:20]([CH3:21])=[O:22]|US09856253B2_1850
2.6.9|[C:5]-[N&H0&+0&D3:4](-[C:3])-O.[C:2]-[O&H1&+0&D1:1]>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[O&H0&+0&D2:1]-[C:2]|[N:1]#[C:2][C:3]([CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][C:9]([CH2:10][CH2:11]1)([C:12](=[O:13])[OH:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1.[O:33]=[C:34]1[CH2:35][CH2:36][C:37]([N:38]1O)=[O:39]>CN(C)C=O.C(=NC1CCCCC1)=NC1CCCCC1>[N:1]#[C:2][C:3]([CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][C:9]([CH2:10][CH2:11]1)([C:12](=[O:13])[O:14][N:38]1[C:37]([CH2:36][CH2:35][C:34]1=[O:33])=[O:39])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1|EP3611169A1_0183
1.2.3|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:5]/[N&H0&+0&D2:4]=[C&H0&+0&D3:2](\[C:3])-[c:1]|[NH2:1][CH2:2][CH2:3][N:4]1[CH2:5][CH2:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[CH2:13]1.[O-:14][N+:15](=[O:16])[c:17]1[cH:18][cH:19][c:20]2[CH2:21][CH2:22][CH2:23][C:24]([c:25]2[cH:26]1)=O>Cc1ccccc1.O=C(O)C(F)(F)F>[O-:14][N+:15](=[O:16])[c:17]1[cH:18][cH:19][c:20]2[CH2:21][CH2:22][CH2:23]/[C:24]([c:25]2[cH:26]1)=[N:1]\[CH2:2][CH2:3][N:4]1[CH2:5][CH2:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[CH2:13]1|US20120065195A1_0692
1.2.6|[C:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[S:1]>>[C:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[S:1])-[c:3]|[CH3:1][C@H:2]([NH:3][C:4](=[O:5])[O:6][C:7]([CH3:8])([CH3:9])[CH3:10])[C:11](=O)[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[F:18].[CH3:19][C:20]([CH3:21])([CH3:22])[S:23]([NH2:24])=[O:25]>>[CH3:8][C:7]([CH3:9])([CH3:10])[O:6][C:4](=[O:5])[NH:3][C@@H:2]([CH3:1])[C:11](=[N:24][S:23](=[O:25])[C:20]([CH3:19])([CH3:21])[CH3:22])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[F:18]|US20120065195A1_0605
1.7.11|[C:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][c:7]([cH:8][c:9]([n:10]1)[C:11]([F:12])([F:13])[F:14])[N:15]1[CH2:16][CH2:17][N:18]([CH2:19][CH2:20]1)[CH2:21][CH2:22][CH2:23][OH:24].[CH3:25][n:26]1[c:27]([n:28][n:29][c:30]1I)-[c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1>Cn1cnnc1-c1ccccc1.CN(C)C=O.OCCCCl.O.[NaH]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:10][c:9]([cH:8][c:7]([n:6]1)[N:15]1[CH2:16][CH2:17][N:18]([CH2:19][CH2:20]1)[CH2:21][CH2:22][CH2:23][O:24][c:30]1[n:29][n:28][c:27]([n:26]1[CH3:25])-[c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)[C:11]([F:12])([F:13])[F:14]|EP0994865B1_0055
2.6.2|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|I[c:1]1[cH:2][cH:3][cH:4][cH:5][cH:6]1.[CH3:7][C:8](=[O:9])[OH:10]>c1ccccc1>[CH3:7][C:8](=[O:9])[O:10][c:1]1[cH:6][cH:5][cH:4][cH:3][cH:2]1|US07994209B2_0759
1.8.13|[C:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([c:8]2[cH:9][c:10]([c:11]([c:12]([c:13]2[n:14]1)[CH2:15][CH2:16][CH3:17])[OH:18])[C:19]([CH3:20])=[O:21])Cl.[CH3:22][CH2:23][S-:24]>Cl.CCOC(C)=O.CCS.CN(C)C=O.[NaH]>[CH3:22][CH2:23][S:24][c:7]1[cH:6][c:5]([n:14][c:13]2[c:12]([c:11]([c:10]([cH:9][c:8]21)[C:19]([CH3:20])=[O:21])[OH:18])[CH2:15][CH2:16][CH3:17])[C:3](=[O:4])[O:2][CH3:1]|EP3317276B1_0150
1.7.11|[C:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O-:9].[F:10][c:11]1[cH:12][c:13]([cH:14][n:15][c:16]1Br)[Br:17].[Li+]>CCCCCC.CCCCCCCCO.CCCC[Li].C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][c:16]1[n:15][cH:14][c:13]([cH:12][c:11]1[F:10])[Br:17]|US06465467B1
1.2.6|[C:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[O:1]>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[O:1]|Cl.[CH3:1][C:2](=[O:3])[O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1=[CH:11][CH2:12][CH2:13][C:14]1=O.[CH3:15][O:16][NH2:17]>CCO.c1ccncc1>[CH3:15][O:16][N:17]=[C:14]1[CH2:13][CH2:12][CH:11]=[C:10]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][O:4][C:2]([CH3:1])=[O:3]|US10759781B2_2901
10.4.3|[O&H2&+0&D0:4].[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[C:1]>>[O&H1&+0&D1:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[C:1]|[OH2:1].[CH2:2]=[CH:3][CH2:4][CH:5]([CH2:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[F:14])[O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>[Na+].CCOCC.OO.O[Na].FB(F)F.C1CCOC1.[H-].[BH4-]>[OH:1][CH2:2][CH2:3][CH2:4][CH:5]([CH2:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[F:14])[O:15][CH2:16][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|EP3004084B1_0333
1.2.5|[C:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[c:3]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][C:8](=O)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15].[NH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH:8]([NH:16][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15]|US08436043B2_2202
1.7.11|[C:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][CH2:2][O-:3].[CH3:4][S:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1Cl>[O-][N+](=O)c1ccccc1.[Cu]>[CH3:1][CH2:2][O:3][c:11]1[cH:10][cH:9][cH:8][cH:7][c:6]1[S:5][CH3:4]|US20020137736A1_0303
1.2.3|[C:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][n:6][cH:7]1.O=[C:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[cH:5]1[cH:4][cH:3][c:2]([cH:7][n:6]1)[N:1]=[C:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20180305298A1_0220
1.8.12|[C:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[s:8][c:9]([n:10][c:11]12)[NH:12][C:13](=[O:14])[c:15]1[cH:16][cH:17][n:18][c:19]([cH:20]1)Br)[N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1.[CH3:27][CH2:28][S-:29].[Na+]>C1COCCO1.CN(C)C=O>[CH3:27][CH2:28][S:29][c:19]1[cH:20][c:15]([cH:16][cH:17][n:18]1)[C:13](=[O:14])[NH:12][c:9]1[n:10][c:11]2[c:3]([cH:4][cH:5][c:6]([c:7]2[s:8]1)[N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1)[O:2][CH3:1]|US20200181172A1_0781
1.2.6|[C:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[N:1]>>[C:5]/[C&H0&+0&D3:4](=[N&H0&+0&D2:2]\[N:1])-[c:3]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]2[C:10]([C:11]([N:12]([c:13]21)[CH2:14][CH2:15][N:16]([CH:17]([CH3:18])[CH3:19])[CH:20]([CH3:21])[CH3:22])=[O:23])=O.[NH2:24][NH:25][C:26]([NH2:27])=[O:28].Cl>>[CH3:21][CH:20]([CH3:22])[N:16]([CH2:15][CH2:14][N:12]1[C:11](/[C:10]([c:9]2[cH:8][cH:7][cH:6][c:5]([c:13]21)[C:3](=[O:4])[O:2][CH3:1])=[N:24]\[NH:25][C:26]([NH2:27])=[O:28])=[O:23])[CH:17]([CH3:18])[CH3:19]|US20170001970A1_0224
1.7.9|[C:5]-[C&H1&+0&D3:4](-[C:3])-I.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[CH2:9][CH:10]1[c:11]2[cH:12][c:13]([c:14]([cH:15][c:16]2[CH:17]=[CH:18][N:19]1[C:20](=[O:21])[O:22][CH2:23][CH3:24])[OH:25])[O:26][CH3:27].I[CH:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1>CCCCCC.CCOC(C)=O.CN(C)C=O.O=C(O[K])O[K]>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[CH2:9][CH:10]1[c:11]2[cH:12][c:13]([c:14]([cH:15][c:16]2[CH:17]=[CH:18][N:19]1[C:20](=[O:21])[O:22][CH2:23][CH3:24])[O:25][CH:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1)[O:26][CH3:27]|US20200289507A1_2168
1.6.8|[C:5]=[N&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH3:15][c:16]1[cH:17][c:18]([cH:19][c:20]([cH:21]1)I)[CH3:22]>CCCCCCCCCCCC.N[C@@H]1CCCC[C@H]1N.CC(C)(C)O[Na].C1COCCO1.I[Cu]>[CH3:15][c:16]1[cH:17][c:18]([cH:19][c:20]([cH:21]1)[N:1]=[C:2]([c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1)[CH3:22]|US10787452B2_1451
1.7.11|[C:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O-:1][N+:2](=[O:3])[c:4]1[c:5]([n:6][c:7]([n:8][c:9]1[Cl:10])[N:11]1[CH2:12][CH2:13][S:14][CH2:15][CH2:16]1)Cl.[CH3:17][CH2:18][O-:19].[Na+]>C1COCCO1.CC(C)=O.CCO.[Na]>[CH3:17][CH2:18][O:19][c:5]1[n:6][c:7]([n:8][c:9]([c:4]1[N+:2]([O-:1])=[O:3])[Cl:10])[N:11]1[CH2:12][CH2:13][S:14][CH2:15][CH2:16]1|US07960365B2_0046
9.7.33|[N&H3&+0&D0:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][CH:2]([C:3](=[O:4])O)[c:5]1[cH:6][cH:7][c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[cH:14]1)[F:15].[NH3:16]>c1ccccc1.C(C#[O+])#[O+].[Cl-].[Cl-].[NaH]>[CH3:1][CH:2]([C:3]([NH2:16])=[O:4])[c:5]1[cH:6][cH:7][c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[cH:14]1)[F:15]|US20170183318A1_0179
1.2.3|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](-[N:1])=O>>[C:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[N:1]|[CH3:1][CH:2]([NH2:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[CH3:18][N:19]1[CH2:20][CH2:21][CH2:22][C:23]1=O.Cl.[ClH:24]>c1ccccc1.O=P(Cl)(Cl)Cl>[CH3:18][N:19]1[CH2:20][CH2:21][CH2:22][C:23]1=[N:3][CH:2]([CH3:1])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[ClH:24]|US20200308152A1_0051
1.7.11|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][OH:3].[I:4][c:5]1[cH:6][n:7][cH:8][c:9]([n:10]1)I>[Na]>[CH3:1][CH2:2][O:3][c:9]1[cH:8][n:7][cH:6][c:5]([n:10]1)[I:4]|EP3270920B1_0063
1.2.3|[C:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[c:7]1[cH:8][cH:9][cH:10][n:11]1[CH3:12].[CH3:13][O:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[NH2:21]>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:13][O:14][c:15]1[cH:20][cH:19][c:18]([cH:17][cH:16]1)[N:21]=[C:6]([C:4](=[O:5])[O:3][CH2:2][CH3:1])[c:7]1[cH:8][cH:9][cH:10][n:11]1[CH3:12]|US20040092570A1_0853
1.2.9|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[C:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[C:1]|[NH2:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[O-:9][N+:10](=[O:11])[C:12]1=[C:13]([C:14]([NH:15][C:16]1=[O:17])=[CH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)O>C=[N+]=[N-].CO.CCOCC>[O-:9][N+:10](=[O:11])[C:12]1[C:16]([NH:15][C:14]([C:13]=1[NH:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)=[CH:18][c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1)=[O:17]|EP1792905A1_0126
1.8.7|[C:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[O:8][CH:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[CH2:16][CH2:17][n:18]2[c:19]1[n:20][c:21]([cH:22]2)I.[SH:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>CC1(c2cccc(c2Oc2c1cccc2P(c1ccccc1)c1ccccc1)P(c1ccccc1)c1ccccc1)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)N(CC)C(C)C.C1COCCO1.N.O.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[O:8][CH:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[CH2:16][CH2:17][n:18]2[c:19]1[n:20][c:21]([cH:22]2)[S:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1|EP3544978B1_0290
1.2.3|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][NH2:3].O=[C:4]1[CH2:5][CH2:6][CH:7]([c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]12)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>CN>[CH3:1][CH2:2][N:3]=[C:4]1[CH2:5][CH2:6][CH:7]([c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]12)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US20190389838A1_0300
1.6.4|[C:5]-[N&H1&+0&D2:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[N&H0&+0&D3:4]1-[C&H2&+0&D2:1]-[C:2]-[C:3]-1|[OH:1][CH:2]([CH2:3]Cl)[CH2:4][NH:5][CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1>O>[OH:1][CH:2]1[CH2:3][N:5]([CH2:4]1)[CH2:6][c:7]1[cH:12][cH:11][cH:10][cH:9][cH:8]1|US20170320839A1_0281
1.2.6|[C:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[O:1]>>[C:5]/[C&H0&+0&D3:4](=[N&H0&+0&D2:2]\[O:1])-[c:3]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][O:6][NH2:7].[O:8]=[C:9]([CH2:10][Cl:11])[NH:12][c:13]1[n:14][c:15]([cH:16][s:17]1)[C:18](=O)[C:19](=[O:20])[OH:21]>O.[Na+].[O-]C(=O)O.O[Na].C1CCOC1>[CH3:1][O:2][C:3](=[O:4])[CH2:5][O:6]/[N:7]=[C:18](\[C:19](=[O:20])[OH:21])[c:15]1[cH:16][s:17][c:13]([n:14]1)[NH:12][C:9](=[O:8])[CH2:10][Cl:11]|US20200297702A1_0727
1.3.8|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|F[c:1]1[cH:2][c:3]([n:4][c:5]([n:6]1)[F:7])[C:8]([F:9])([F:10])[F:11].[NH2:12][CH:13]1[CH2:14][CH2:15]1>>[F:9][C:8]([F:10])([F:11])[c:3]1[cH:2][c:1]([n:6][c:5]([n:4]1)[F:7])[NH:12][CH:13]1[CH2:14][CH2:15]1|US20110028492A1_0540
9.7.219|[C:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[n:3][s:4][c:5]([c:6]1Br)[NH2:7].[N:8]#[C:9][S-:10].[K+]>CO>[CH3:1][c:2]1[n:3][s:4][c:5]([c:6]1[S:10][C:9]#[N:8])[NH2:7]|US10457637B2_0335
1.7.11|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[OH:4].[CH3:5][CH:6]1[CH2:7][CH2:8][CH2:9][N:10]([CH2:11]1)[S:12](=[O:13])(=[O:14])[c:15]1[cH:16][cH:17][c:18]([c:19]([cH:20]1)[C:21](=[O:22])[OH:23])F>CC1CCCNC1.O=C(O)c1cc(ccc1F)S(=O)(=O)Cl.[NaH]>[CH3:5][CH:6]1[CH2:7][CH2:8][CH2:9][N:10]([CH2:11]1)[S:12](=[O:13])(=[O:14])[c:15]1[cH:16][cH:17][c:18]([c:19]([cH:20]1)[C:21](=[O:22])[OH:23])[O:4][CH:2]([CH3:1])[CH3:3]|US09738656B2_0415
1.2.6|[C:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[N:1]>>[C:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[N:1])-[c:3]|[CH3:1][O:2][C:3](=[O:4])[NH:5][NH2:6].[NH2:7][C:8](=[O:9])[NH:10][CH:11]1[CH2:12][CH2:13][C:14]([c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21)=O>Cl.CCO>[CH3:1][O:2][C:3](=[O:4])[NH:5][N:6]=[C:14]1[CH2:13][CH2:12][CH:11]([c:20]2[cH:19][cH:18][cH:17][cH:16][c:15]12)[NH:10][C:8]([NH2:7])=[O:9]|US20080004274A1_0489
9.7.165|[N&H4&+&D0:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[NH4+:1].[O:2]=[C:3]([c:4]1[cH:5][cH:6][cH:7][s:8]1)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[C:15]1([CH2:16][CH2:17]1)[C:18](=[O:19])Cl.[OH-]>>[NH2:1][C:18](=[O:19])[C:15]1([CH2:16][CH2:17]1)[c:12]1[cH:13][cH:14][c:9]([cH:10][cH:11]1)[C:3](=[O:2])[c:4]1[cH:5][cH:6][cH:7][s:8]1|US20200291027A1_1458
1.2.6|[C:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[N:1]>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[N:1]|Cl.[NH2:1][NH:2][C:3]([NH2:4])=[O:5].[O:6]=[C:7]([OH:8])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[C:16]([CH2:17][CH:18]([C:19]=1[CH:20]=[CH:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[OH:28])=O>O.CCO.c1ccncc1>[NH2:4][C:3](=[O:5])[NH:2][N:1]=[C:16]1[CH2:17][CH:18]([C:19](=[C:15]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:7](=[O:6])[OH:8])[CH:20]=[CH:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[OH:28]|EP1945222B1_1171
1.3.9|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][CH2:2][CH2:3][O:4][c:5]1[cH:6][cH:7][c:8]([n:9][c:10]1I)[I:11]>CC(C)N(CC)C(C)C>[I:11][c:8]1[cH:7][cH:6][c:5]2[O:4][CH2:3][CH2:2][NH:1][c:10]2[n:9]1|EP2751106B1_0438
1.2.5|[C:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][N:2]1[CH2:3][C:4]([CH2:5][C@@H:6]2[c:7]3[cH:8][cH:9][cH:10][c:11]4[nH:12][cH:13][c:14]([CH2:15][C@H:16]21)[c:17]43)=O.[NH2:18][c:19]1[cH:20][cH:21][cH:22][n:23][cH:24]1.O=C(O)/C=C\C(=O)O>CO.[H][H].C.[Pd]>[CH3:1][N:2]1[CH2:3][CH:4]([CH2:5][C@@H:6]2[c:7]3[cH:8][cH:9][cH:10][c:11]4[nH:12][cH:13][c:14]([CH2:15][C@H:16]21)[c:17]34)[NH:18][c:19]1[cH:24][n:23][cH:22][cH:21][cH:20]1|US09115151B2_1403
1.2.9|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-O>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][CH2:12][NH2:13].O[c:14]1[n:15][cH:16][n:17][c:18]2[cH:19][cH:20][n:21][cH:22][c:23]21>C[Si](C)(C)N[Si](C)(C)C>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][CH2:12][NH:13][c:14]1[n:15][cH:16][n:17][c:18]2[cH:19][cH:20][n:21][cH:22][c:23]12|US09604994B2_1021
1.2.20|[O:5]-[C&H2&+0&D2:4]-O-C.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[O:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[c:2]1[cH:3][c:4]([n:5][c:6]([nH:7]1)-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[C:14]([F:15])([F:16])[F:17].[CH3:18][O:19][CH2:20]OC>O=P12OP3(OP(O2)(OP(O1)(O3)=O)=O)=O.CCCCCC.CCOC(C)=O.ClC(Cl)Cl.ClCCl.O[Na]>[CH3:18][O:19][CH2:20][n:7]1[c:2]([cH:3][c:4]([n:5][c:6]1-[c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1)[C:14]([F:15])([F:16])[F:17])=[O:1]|EP0766691B1_0074
1.2.3|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][CH:3]1[CH2:4][CH2:5][CH2:6][CH:7]([C:8]1=O)[CH3:9].[CH3:10][O:11][CH2:12][CH:13]([CH3:14])[NH2:15]>Cc1ccccc1.CCOCC.Cl[Ti](Cl)(Cl)Cl>[CH3:1][CH2:2][CH:3]1[CH2:4][CH2:5][CH2:6][CH:7]([C:8]1=[N:15][CH:13]([CH3:14])[CH2:12][O:11][CH3:10])[CH3:9]|US09771372B2_0349
9.7.165|[N&H4&+&D0:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH4+:1].[O:2]=[c:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[o:10][cH:11][c:12]1[C:13](=[O:14])Cl.[OH-]>>[NH2:1][C:13](=[O:14])[c:12]1[cH:11][o:10][c:9]2[cH:8][cH:7][cH:6][cH:5][c:4]2[c:3]1=[O:2]|US20200039945A1_0666
9.7.173|[O&H2&+0&D0:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-N>>[O&H1&+0&D1:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[OH2:1].N[C:2](=[O:3])[CH2:4][c:5]1[c:6]([n:7][n:8]([c:9]1[Cl:10])-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23]>O=NO[Na].O=S(=O)(O)O>[O:3]=[C:2]([OH:1])[CH2:4][c:5]1[c:6]([n:7][n:8]([c:9]1[Cl:10])-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23]|US07371865B2_0210
1.2.9|[C:5]-[C&H1&+0&D3:4](-[O:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[O:3]|[CH3:1][n:2]1[cH:3][n:4][c:5]([cH:6]1)-[c:7]1[cH:8][c:9]2[n:10][cH:11][cH:12][c:13]([c:14]2[s:15]1)[O:16][c:17]1[cH:18][cH:19][c:20]([cH:21][c:22]1[F:23])[NH2:24].[CH3:25][CH2:26][O:27][CH:28](O)[C:29]([F:30])([F:31])[F:32]>Cc1ccc(cc1)S(=O)(=O)O.CCO.O>[CH3:1][n:2]1[cH:3][n:4][c:5]([cH:6]1)-[c:7]1[cH:8][c:9]2[n:10][cH:11][cH:12][c:13]([c:14]2[s:15]1)[O:16][c:17]1[cH:18][cH:19][c:20]([cH:21][c:22]1[F:23])[NH:24][CH:28]([O:27][CH2:26][CH3:25])[C:29]([F:30])([F:31])[F:32]|US09567362B2_0615
1.7.9|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[O:1])-F>>[C:5]-[O&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O:1]|[CH3:1][C:2](=[O:3])[O:4][CH:5]1[CH:6]([O:7][CH:8]([CH2:9][CH:10]1[N:11]([CH3:12])[CH3:13])[CH3:14])F.[OH:15][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1>CCOCC.CCOC(C)=O.O=[Si]=O.FB(F)F>[CH3:14][CH:8]1[CH2:9][CH:10]([CH:5]([CH:6]([O:7]1)[O:15][CH:16]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1)[O:4][C:2]([CH3:1])=[O:3])[N:11]([CH3:12])[CH3:13]|US20120190635A1_0148
1.2.20|[C:5]-[N&H1&+0&D2:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-O-C>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|CO[CH2:1][CH2:2][n:3]1[n:4][cH:5][c:6]([c:7]1[NH2:8])[C:9]#[N:10].[CH3:11][O:12][CH2:13][CH2:14][O:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[N:22]1[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]1>>[CH3:11][O:12][CH2:13][CH2:14][O:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[N:22]1[CH2:23][CH2:24][N:25]([CH2:26][CH2:27]1)[CH2:1][CH2:2][n:3]1[n:4][cH:5][c:6]([c:7]1[NH2:8])[C:9]#[N:10]|US06284774B1
9.7.173|[O&H2&+0&D0:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-N>>[O&H1&+0&D1:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[OH2:1].[CH3:2][O:3][c:4]1[n:5][s:6][cH:7][c:8]1[C:9](N)=[O:10]>O=NO[Na].O=S(=O)(O)O>[CH3:2][O:3][c:4]1[n:5][s:6][cH:7][c:8]1[C:9](=[O:10])[OH:1]|US07576071B2_0172
9.7.220|[C:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[N:1]#[C:2][S-:3].[F:4][CH:5]([F:6])[C:7]([F:8])([F:9])[c:10]1[n:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[c:18]([n:19]1)Cl.[K]>CC(=O)O.N#CS[K]>[N:1]#[C:2][S:3][c:18]1[n:19][c:10]([n:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]12)[C:7]([F:8])([F:9])[CH:5]([F:4])[F:6]|US20200361895A1_0635
1.2.5|[C:5]-[C&H0&+0&D3:4](-[C:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:1]-[C:2]|[CH3:1][C:2]1([CH:3]2[CH2:4][CH2:5][CH:6]([CH2:7]2)[CH:8]1[CH2:9][CH2:10][C:11](=O)[CH2:12][CH2:13][CH:14]1[CH:15]2[CH2:16][CH2:17][CH:18]([CH2:19]2)[C:20]1([CH3:21])[CH3:22])[CH3:23].[NH2:24][CH2:25][CH:26]([OH:27])[CH2:28][NH2:29]>CCO.[H][H].[O-2].[Pt+2]>[CH3:1][C:2]1([CH:3]2[CH2:7][CH:6]([CH2:5][CH2:4]2)[CH:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13][CH:14]1[CH:15]2[CH2:16][CH2:17][CH:18]([CH2:19]2)[C:20]1([CH3:21])[CH3:22])[NH:24][CH2:25][CH:26]([OH:27])[CH2:28][NH2:29])[CH3:23]|US20130109682A1_0994
1.2.6|[C:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[O:1]>>[C:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[O:1])-[c:3]|[O:1]=[C:2]([OH:3])[C:4](=O)[c:5]1[cH:6][cH:7][cH:8][s:9]1.[CH3:10][C:11]([CH3:12])([CH3:13])[O:14][NH2:15].Cl>O=C(O)O[Na].O.Cl>[CH3:10][C:11]([CH3:12])([CH3:13])[O:14][N:15]=[C:4]([C:2](=[O:1])[OH:3])[c:5]1[cH:6][cH:7][cH:8][s:9]1|US06239288B1
1.2.3|[C:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:2](-[N:3])-[c:1]|[CH3:1][CH:2]([CH3:3])[C:4]([CH3:5])([C:6]([NH2:7])=[O:8])[N:9]1[C:10]([c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[C:17]1=[O:18])=O>O.CCCCCC.Cc1ccccc1>[CH3:1][CH:2]([CH3:3])[C:4]1([C:6]([N:7]=[C:10]2[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3[C:17]([N:9]21)=[O:18])=[O:8])[CH3:5]|US20070049603A1_0541
1.7.11|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[OH:1][CH2:2][CH2:3][OH:4].[F:5][c:6]1[n:7][c:8]([c:9]([cH:10][c:11]1[Cl:12])[Cl:13])F>O.O[Na]>[OH:1][CH2:2][CH2:3][O:4][c:8]1[n:7][c:6]([c:11]([cH:10][c:9]1[Cl:13])[Cl:12])[F:5]|US20200055839A1_1238
2.6.9|[C:5]-[O&H1&+0&D1:4].[c:3]:[n&H0&+0&D3:2](:[n:1])-O>>[C:5]-[O&H0&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2]/[N:3]=[C:4](\[C:5](=[O:6])[OH:7])[c:8]1[cH:9][s:10][c:11]([n:12]1)[NH:13][C:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1.O[n:33]1[n:34][n:35][c:36]2[c:37]1[cH:38][cH:39][cH:40][cH:41]2>C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1>[CH3:1][O:2]/[N:3]=[C:4](\[C:5](=[O:6])[O:7][n:33]1[n:34][n:35][c:36]2[c:37]1[cH:38][cH:39][cH:40][cH:41]2)[c:8]1[cH:9][s:10][c:11]([n:12]1)[NH:13][C:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1|US20060009640A1_0037
1.2.9|[C:5]=[C&H0&+0&D3:4](-[c:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C:5]=[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]2[C:10](=[CH:11][CH2:12][CH:13]([n:14]2[c:15]1=[O:16])[CH3:17])O.[NH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]2[C:10](=[CH:11][CH2:12][CH:13]([n:14]2[c:15]1=[O:16])[CH3:17])[NH:18][c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1|US05350748A
1.2.9|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|O[c:1]1[cH:2][cH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[cH:10]1.[CH3:11][CH2:12][NH2:13]>c1ccc(cc1)OP(Oc1ccccc1)Oc1ccccc1.O>[CH3:11][CH2:12][NH:13][c:1]1[cH:2][cH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[cH:10]1|EP2316820A1_0050
1.2.9|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[O:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O:1]|O.[NH2:1][C:2]([NH2:3])=[O:4].[OH:5][CH2:6][C@H:7]1[O:8][C@H:9]([C@@H:10]([C@H:11]([C@H:12]1[OH:13])[OH:14])[OH:15])[O:16][C@@H:17]1[C@H:18]([O:19][CH:20]([C@@H:21]([C@H:22]1[OH:23])[OH:24])O)[CH2:25][OH:26]>O.O=S(=O)(O)O>[NH2:1][C:2](=[O:4])[NH:3][CH:20]1[O:19][C@@H:18]([C@H:17]([C@@H:22]([C@H:21]1[OH:24])[OH:23])[O:16][C@@H:9]1[O:8][C@@H:7]([C@@H:12]([C@@H:11]([C@H:10]1[OH:15])[OH:14])[OH:13])[CH2:6][OH:5])[CH2:25][OH:26]|US05354905A
1.2.6|[C:5]-[C&H0&+0&D3:4](-[N:3])=O.[N&H2&+0&D1:2]-[S:1]>>[C:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[S:1])-[N:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=O)[NH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[S:15]([NH2:16])(=[O:17])=[O:18]>O=P(Cl)(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]1=[N:16][S:15]([c:14]2[cH:13][cH:12][cH:11][cH:10][c:9]2[NH:8]1)(=[O:17])=[O:18]|US09493484B2_0799
1.2.6|[C:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[S:1]>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[S:1]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.O=[C:11]1[CH:12]2[CH2:13][CH2:14][CH:15]1[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[CH2:23]2>Cc1ccccc1>[O:3]=[S:2](=[O:4])([N:1]=[C:11]1[CH:12]2[CH2:23][c:22]3[cH:21][cH:20][cH:19][cH:18][c:17]3[CH2:16][CH:15]1[CH2:14][CH2:13]2)[c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1|US20200317689A1_0728
1.2.9|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[N:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[N:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[C:7]([C:8](=[N:9][S:10]1(=[O:11])=[O:12])O)[NH:13][c:14]1[cH:15][cH:16][cH:17][c:18]([c:19]1[OH:20])[C:21](=[O:22])[N:23]([CH3:24])[CH3:25].[CH3:26][CH2:27][C@@H:28]([NH2:29])[c:30]1[cH:31][cH:32][c:33]([o:34]1)[CH3:35]>CC(C)N(CC)C(C)C.CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[C:7]([C:8](=[N:9][S:10]1(=[O:11])=[O:12])[NH:29][C@H:28]([CH2:27][CH3:26])[c:30]1[cH:31][cH:32][c:33]([o:34]1)[CH3:35])[NH:13][c:14]1[cH:15][cH:16][cH:17][c:18]([c:19]1[OH:20])[C:21](=[O:22])[N:23]([CH3:24])[CH3:25]|EP0116444A2_0142
1.2.9|[C:5]-[C&H1&+0&D3:4](-[c:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[c:3]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[c:15]1[c:16]([c:17]([c:18]2[O:19][C:20]([CH:21]([c:22]2[c:23]1[CH3:24])O)([CH3:25])[CH3:26])[CH3:27])[CH3:28].[NH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>O.CO.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[c:15]1[c:23]([c:22]2[c:18]([O:19][C:20]([CH:21]2[NH:29][c:30]2[cH:35][cH:34][cH:33][cH:32][cH:31]2)([CH3:25])[CH3:26])[c:17]([c:16]1[CH3:28])[CH3:27])[CH3:24]|US08436043B2_1512
1.2.9|[C:5]-[C&H0&+0&D3:4](=[N:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[N:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[C:7]([C:8](=[N:9][S:10]1(=[O:11])=[O:12])O)[NH:13][C@H:14]([CH2:15][CH3:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1.[CH3:23][N:24]([CH3:25])[C:26](=[O:27])[c:28]1[cH:29][cH:30][cH:31][c:32]([c:33]1[OH:34])[NH2:35]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[C:7]([C:8](=[N:9][S:10]1(=[O:11])=[O:12])[NH:35][c:32]1[cH:31][cH:30][cH:29][c:28]([c:33]1[OH:34])[C:26](=[O:27])[N:24]([CH3:23])[CH3:25])[NH:13][C@H:14]([CH2:15][CH3:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US04297440A
1.2.9|[C:5]-[N&H2&+0&D1:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[c:3])-[c:1]|[CH3:1][N:2]([CH3:3])[NH:4][C:5]([NH2:6])=[O:7].O[CH:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[O:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21>O.O>[CH3:1][N:2]([CH3:3])[NH:4][C:5](=[O:7])[NH:6][CH:8]1[c:21]2[cH:20][cH:19][cH:18][cH:17][c:16]2[O:15][c:14]2[cH:13][cH:12][cH:11][cH:10][c:9]21|US03949076A
1.2.9|[C:5]-[C&H1&+0&D3:4](-[C:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[NH2:8].O[CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1>c1ccc(cc1)OP(Oc1ccccc1)Oc1ccccc1.O>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[NH:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1|US08828987B2_0702
1.7.7|[C:5]-[C&H1&+0&D3:4](-[O:3])-O.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[O:3]|[CH3:1][c:2]1[c:3]([cH:4][cH:5][c:6]2[c:7]([cH:8][c:9]([o:10][c:11]12)=[O:12])[O:13][CH:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[OH:27].[CH3:28][CH2:29][C@@:30]1([O:31][CH:32]([C@@H:33]([C@@H:34]([C@H:35]1[O:36][CH3:37])[OH:38])[OH:39])O)[CH3:40]>>[CH3:28][CH2:29][C@@:30]1([O:31][CH:32]([C@@H:33]([C@@H:34]([C@H:35]1[O:36][CH3:37])[OH:38])[OH:39])[O:27][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8][c:9]([o:10][c:11]2[c:2]1[CH3:1])=[O:12])[O:13][CH:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[CH3:40]|US07566699B2_0496
1.8.15|[C:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1I)[O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[Cl:17])[C:18]([F:19])([F:20])[F:21].[CH3:22][CH2:23][SH:24]>CN(C)C=O.Cl.[O-2].[NaH].[Cu+].[Cu+]>[CH3:22][CH2:23][S:24][c:9]1[cH:8][cH:7][c:6]([cH:5][c:4]1[C:2](=[O:1])[OH:3])[O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[Cl:17])[C:18]([F:19])([F:20])[F:21]|US07566786B2_0621
1.3.9|[C:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[NH2:8].[CH3:9][n:10]1[n:11][c:12]([c:13]2[CH2:14][CH2:15][c:16]3[cH:17][n:18][c:19]([n:20][c:21]3-[c:22]21)I)[C:23]([NH2:24])=[O:25]>>[CH3:9][n:10]1[n:11][c:12]([c:13]2[CH2:14][CH2:15][c:16]3[cH:17][n:18][c:19]([n:20][c:21]3-[c:22]21)[NH:8][CH:5]1[CH2:6][CH2:7][N:2]([CH2:3][CH2:4]1)[CH3:1])[C:23]([NH2:24])=[O:25]|EP1836174B1_0783
1.2.5|[C:5]-[N&H2&+0&D1:4].[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[c:3])-[c:1]|[NH2:1][C@H:2]1[CH2:3][CH2:4][N:5]([C@@H:6]([CH2:7]1)[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[C:15](=[O:16])[c:17]1[cH:18][c:19]([cH:20][c:21]([cH:22]1)[Cl:23])[Cl:24].O=[C:25]([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1>[Na+].Cc1ccccc1.CC(=O)O.N#C[BH3-]>[O:16]=[C:15]([c:17]1[cH:18][c:19]([cH:20][c:21]([cH:22]1)[Cl:23])[Cl:24])[N:5]1[CH2:4][CH2:3][C@@H:2]([CH2:7][C@H:6]1[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[NH:1][CH:25]([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:32]1[cH:37][cH:36][cH:35][cH:34][cH:33]1|US20200255379A1_0326
1.2.9|[C:5]-[C&H1&+0&D3:4](-[N:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[N:3]|[O:1]=[C:2]([NH:3][CH:4](O)[C:5]([Cl:6])([Cl:7])[Cl:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Br:15].[NH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23]>O=C(NC(Cl)C(Cl)(Cl)Cl)c1ccc(cc1)Br.ClP(Cl)(Cl)(Cl)Cl.ClC(Cl)Cl>[O:1]=[C:2]([NH:3][CH:4]([NH:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23])[C:5]([Cl:6])([Cl:7])[Cl:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Br:15]|US20200361878A1_0022
1.2.9|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[c:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|O[CH:1]1[CH2:2][CH2:3][CH2:4][c:5]2[s:6][cH:7][cH:8][c:9]21.[NH2:10][C:11]([NH2:12])=[O:13]>ClC1CCCc2sccc21.CC(C)N(CC)C(C)C.CN(C)C=O.O=S(Cl)Cl>[NH2:10][C:11](=[O:13])[NH:12][CH:1]1[CH2:2][CH2:3][CH2:4][c:5]2[s:6][cH:7][cH:8][c:9]21|US08357706B2_0380
2.6.9|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[ClH:1].[CH3:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([CH3:8])[CH:9]([CH3:10])[c:11]1[cH:12][c:13]([c:14]2[C:15]3[CH2:16][CH2:17][S:18][C:19]=3[C:20]([O:21][c:22]2[cH:23]1)([CH3:24])[CH3:25])O.[O:26]=[C:27]([OH:28])[CH2:29][CH2:30][CH2:31][N:32]1[CH2:33][CH2:34][O:35][CH2:36][CH2:37]1>ClCCl.C(=NC1CCCCC1)=NC1CCCCC1>[ClH:1].[CH3:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([CH3:8])[CH:9]([CH3:10])[c:11]1[cH:23][c:22]2[O:21][C:20]([C:19]3[S:18][CH2:17][CH2:16][C:15]=3[c:14]2[c:13]([cH:12]1)[O:28][C:27](=[O:26])[CH2:29][CH2:30][CH2:31][N:32]1[CH2:33][CH2:34][O:35][CH2:36][CH2:37]1)([CH3:24])[CH3:25]|US06407092B1
1.7.11|[C:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][OH:3].[NH2:4][c:5]1[n:6][c:7]([n:8][c:9]([n:10]1)[O:11][C:12]([F:13])([F:14])[F:15])F>[NaH]>[CH3:1][CH2:2][O:3][c:7]1[n:6][c:5]([n:10][c:9]([n:8]1)[O:11][C:12]([F:13])([F:14])[F:15])[NH2:4]|US20200181118A1_1708
1.2.6|[C:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[n:1]>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[n:1]|[CH3:1][C@H:2]1[CH2:3][CH2:4][C:5]([CH2:6]1)=O.[NH2:7][n:8]1[c:9]([c:10]([c:11]([c:12]2[s:13][cH:14][cH:15][c:16]21)[OH:17])[C:18]1=[N:19][S:20]([c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[NH:27]1)(=[O:28])=[O:29])=[O:30]>CC(=O)N(C)C>[CH3:1][C@H:2]1[CH2:3][CH2:4][C:5]([CH2:6]1)=[N:7][n:8]1[c:9]([c:10]([c:11]([c:12]2[s:13][cH:14][cH:15][c:16]21)[OH:17])[C:18]1=[N:19][S:20]([c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[NH:27]1)(=[O:28])=[O:29])=[O:30]|US20090270443A1_0857
1.2.5|[N&H3&+0&D0:4].[C&H3&D1:3]-[C&H0&+0&D3:2](-[C:1])=O>>[N&H2&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[C:1]|[NH3:1].[CH3:2][C:3](=O)[CH2:4][N:5]1[CH2:6][CH2:7][CH:8]([CH2:9][CH2:10]1)[NH:11][c:12]1[n:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]2[n:20]1[CH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28]>CO.[H][H].[Ni]>[CH3:2][CH:3]([NH2:1])[CH2:4][N:5]1[CH2:6][CH2:7][CH:8]([CH2:9][CH2:10]1)[NH:11][c:12]1[n:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]2[n:20]1[CH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28]|EP2797884B1_0204
8.4.3|[C:5]-[N&H0&+0&D3:4](-[C:3])-[C:2].[O&H1&+0&D1:1]-O>>[C:5]-[N&H0&+&D4:4](-[C:3])(-[C:2])-[O&H0&-&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[CH:5]1[CH2:6][c:7]2[c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[n:14]([c:15]2[CH2:16][CH2:17]1)[CH2:18][CH2:19][N:20]1[CH2:21][CH2:22][CH2:23][CH2:24]1.[OH:25]O>[O-][Mn](=O)(=O)=O.CO.O.O.O.[K+]>[CH3:1][C:2]([CH3:3])([CH3:4])[CH:5]1[CH2:6][c:7]2[c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[n:14]([c:15]2[CH2:16][CH2:17]1)[CH2:18][CH2:19][N+:20]1([CH2:21][CH2:22][CH2:23][CH2:24]1)[O-:25]|US20200308213A1_0086
10.4.3|[O&H2&+0&D0:4].[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[O&H1&+0&D1:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]|[CH2:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[CH2:9][CH2:10][N:11]2[C:12]([CH3:13])=[O:14].C[N+](C)(C)[O-].[OH2:15].O>C1CCO(C1)[BH3].C1CCOC1.O.Cl>[CH3:13][C:12](=[O:14])[N:11]1[CH2:10][CH2:9][c:7]2[cH:8][c:3]([cH:4][cH:5][c:6]21)[CH2:2][CH2:1][OH:15]|US20190284189A1_0432
1.7.11|[C:5]-[O&H0&-&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Na+].[CH3:1][CH2:2][O-:3].[CH3:4][CH:5]([CH3:6])[NH:7][c:8]1[n:9][c:10]([n:11][c:12]2[cH:13][s:14][cH:15][c:16]21)Cl>CCO>[CH3:4][CH:5]([CH3:6])[NH:7][c:8]1[n:9][c:10]([n:11][c:12]2[cH:13][s:14][cH:15][c:16]21)[O:3][CH2:2][CH3:1]|EP3546457A1_0158
1.2.3|[C:5]-[N&H2&+0&D1:4].[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][n:2]1[n:3][cH:4][c:5]([c:6]1-[c:7]1[cH:8][cH:9][c:10]([cH:11][c:12]1[C:13](=O)[c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[F:20])[Cl:21])[CH2:22][NH2:23].O=P(O)(O)O>O[Na].ClCCl>[CH3:1][n:2]1[n:3][cH:4][c:5]2[CH2:22][N:23]=[C:13]([c:12]3[cH:11][c:10]([cH:9][cH:8][c:7]3-[c:6]21)[Cl:21])[c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[F:20]|US20160016907A1_0425
1.8.15|[C:5]-[C&H1&+0&D3:4](-[C:3])-I.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[SH:13].I[CH:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1>CCN(CC)CC.CN(C)C=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[S:13][CH:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1|US09096584B2_0257
2.6.9|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[O:1])-O>>[C:5]-[O&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O:1]|O[CH:1]1[O:2][C@@H:3]([C@H:4]([C@@H:5]([C@H:6]1[O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[O:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[CH2:31][O:32][CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1.[O:40]=[C:41]([OH:42])[CH2:43][C:44](=[O:45])[O:46][CH2:47][C:48]([Cl:49])([Cl:50])[Cl:51]>C(=NC1CCCCC1)=NC1CCCCC1.c1ccncc1.CCOCC.ClCCl>[O:40]=[C:41]([CH2:43][C:44](=[O:45])[O:46][CH2:47][C:48]([Cl:49])([Cl:50])[Cl:51])[O:42][CH:1]1[O:2][C@@H:3]([C@H:4]([C@@H:5]([C@H:6]1[O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[O:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[CH2:31][O:32][CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1|US09427475B2_0401
1.2.9|[C:5]-[C&H0&+0&D3:4](=[C:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[C:5](/O)=[CH:6]/[C:7](=[O:8])[C:9]([CH3:10])([CH3:11])[CH3:12].[NH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Br:20]>C[OH2]>[CH3:10][C:9]([CH3:11])([CH3:12])[C:7](=[O:8])/[CH:6]=[C:5](\[NH:13][c:14]1[cH:19][cH:18][c:17]([cH:16][cH:15]1)[Br:20])[C:3](=[O:4])[O:2][CH3:1]|US09290459B1_0378
1.6.4|[C:5]-[C&H1&+0&D3:4](-[c:3])-Cl.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[c:3]|Cl.[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[O:8]=[c:9]1[cH:10][cH:11][c:12]2[CH2:13][CH2:14][CH2:15][CH:16]([c:17]2[nH:18]1)Cl>CC(C)O>[O:8]=[c:9]1[cH:10][cH:11][c:12]2[CH2:13][CH2:14][CH2:15][CH:16]([c:17]2[nH:18]1)[NH:1][c:2]1[cH:7][cH:6][cH:5][cH:4][cH:3]1|US10550123B2_1727
9.7.245|[O&H2&+0&D0:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[O&H1&+0&D1:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[OH2:1].[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[C:10](=[O:11])Cl)[Cl:12]>[Na+].Cl.CC(C)=O.[OH-]>[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[C:10](=[O:11])[OH:1])[Cl:12]|EP2608791B1_0024
2.6.2|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Cl)[C:7]([CH3:8])=[O:9].[O:10]=[C:11]([OH:12])[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19]>CN(C)C=O.O=C(O[Na])O[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([O:12][C:11](=[O:10])[c:13]1[cH:18][cH:17][c:16]([cH:15][cH:14]1)[Cl:19])[C:7]([CH3:8])=[O:9]|US20130252943A1_0547
1.6.2|[C:5]=[N&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C@@H:2]1[CH2:3][N:4]([CH2:5][C@H:6]2[CH2:7][c:8]3[cH:9][cH:10][c:11]([n:12][c:13]3[N:14]12)Br)[C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21].[NH:22]=[C:23]([c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>Cc1ccccc1.CC(C)(C)O[Na].O=C(O)O[Na]>[CH3:1][C@@H:2]1[CH2:3][N:4]([CH2:5][C@H:6]2[CH2:7][c:8]3[cH:9][cH:10][c:11]([n:12][c:13]3[N:14]12)[N:22]=[C:23]([c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[c:30]1[cH:35][cH:34][cH:33][cH:32][cH:31]1)[C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21]|US20200165259A1_0207
1.3.6|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][c:2]1[n:3][c:4]([c:5]([s:6]1)Br)[CH3:7].[CH3:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[CH2:15][CH2:16][NH2:17]>CCOC(C)=O.CS(C)=O.O=C(O[K])O[K]>[CH3:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[CH2:15][CH2:16][NH:17][c:5]1[s:6][c:2]([n:3][c:4]1[CH3:7])[CH3:1]|US20200270273A1_0256
1.8.12|[C:5]-[C&H1&+0&D3:4](-[C:3])-Br.[C:2]-[S&H1&+0&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[S&H0&+0&D2:1]-[C:2]|[CH3:1][O:2][C:3](=[O:4])[CH:5](Br)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]#[N:13].[CH3:14][CH2:15][O:16][CH:17]([CH2:18][SH:19])[O:20][CH2:21][CH3:22]>CCN(CC)CC.ClCCl>[CH3:14][CH2:15][O:16][CH:17]([CH2:18][S:19][CH:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]#[N:13])[C:3](=[O:4])[O:2][CH3:1])[O:20][CH2:21][CH3:22]|US20050171163A1_0222
1.7.11|[C:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[o:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[o:1]|[CH3:1][C:2]1([CH2:3][CH:4]([CH2:5][C:6]([NH:7]1)([CH3:8])[CH3:9])[O:10][CH2:11][CH2:12][OH:13])[CH3:14].Cl[c:15]1[n:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[o:23]1>CCC(C)=O.[O-]C([O-])=O.[K+].[K+]>[CH3:1][C:2]1([CH2:3][CH:4]([CH2:5][C:6]([NH:7]1)([CH3:8])[CH3:9])[O:10][CH2:11][CH2:12][O:13][c:15]1[n:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[o:23]1)[CH3:14]|EP0500934A1_0033
1.7.11|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7][n:8][c:9]2Cl)[s:10]1.[CH3:11][C:12]([CH3:13])([CH3:14])[NH:15][CH2:16][CH:17]([OH:18])[CH2:19][OH:20]>CC(C)(C)O.[K]>[CH3:11][C:12]([CH3:13])([CH3:14])[NH:15][CH2:16][CH:17]([OH:18])[CH2:19][O:20][c:9]1[n:8][cH:7][cH:6][c:5]2[s:10][c:2]([cH:3][c:4]21)[CH3:1]|US20190345139A1_0435
1.3.7|[C:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[N:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[N:1]|[CH3:1][O:2][CH:3]([CH2:4][NH2:5])[O:6][CH3:7].[CH3:8][N:9]1[C:10](=[N:11][c:12]2[cH:13][cH:14][c:15]([cH:16][c:17]2[CH:18]1[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[Cl:25])Cl>O.O>[CH3:1][O:2][CH:3]([CH2:4][NH:5][C:10]1=[N:11][c:12]2[cH:13][cH:14][c:15]([cH:16][c:17]2[CH:18]([N:9]1[CH3:8])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[Cl:25])[O:6][CH3:7]|EP0159533A2_0104
1.8.13|[C:5]-[S&H1&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][CH:3](Cl)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[F:16].[CH3:17][O:18][C:19](=[O:20])[CH2:21][SH:22]>O=C(CCc1ccc(cc1)-c1ccccc1F)CCc1ccc(cc1)-c1ccccc1F.CCC(O)c1ccc(cc1)-c1ccccc1F.CCOC(C)=O.c1ccccc1.CN(C)C=O.CC(C)(C)[O-].O.[Na+].Cl.[BH4-].[K].[K+]>[CH3:17][O:18][C:19](=[O:20])[CH2:21][S:22][CH:3]([CH2:2][CH3:1])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[F:16]|EP0202759B1_0066
10.1.1|[Br&H0&+0&D1:4]-Br.[C&H3&D1:3]-[C&H2&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[C:1]|[CH3:1][CH2:2][C:3](=[C:4]([C:5]#[N:6])[C:7]#[N:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[Br:15]Br>CC(=O)c1ccccc1.c1ccccc1>[CH3:1][CH:2]([Br:15])[C:3](=[C:4]([C:5]#[N:6])[C:7]#[N:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US20200369633A1_3376
1.7.11|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[OH:1][CH2:2][CH2:3][OH:4].Br[c:5]1[cH:6][cH:7][cH:8][s:9]1>[Na+].CO.C[O-].I[Na].[O-2].[Cu+2]>[OH:1][CH2:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][s:9]1|US20170349594A1_1695
1.3.6|[C:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[NH2:1][CH2:2][CH2:3][CH2:4][NH2:5].Br[c:6]1[n:7][cH:8][cH:9][cH:10][n:11]1>[Na+].CC[O-].CCO>[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[n:7][cH:8][cH:9][cH:10][n:11]1|US20180370972A1_0988
1.7.9|[C:5]-[C&H1&+0&D3:4](-[O:3])-Br.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[O:3]|[CH3:1][c:2]1[cH:3][c:4]([n:5][c:6]([n:7]1)[OH:8])[CH3:9].[CH3:10][O:11][C:12](=[O:13])[CH:14](Br)[O:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>O=c1nccc[nH]1.C1CCOC1.[NaH]>[CH3:10][O:11][C:12](=[O:13])[CH:14]([O:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[O:8][c:6]1[n:7][c:2]([cH:3][c:4]([n:5]1)[CH3:9])[CH3:1]|US20170182179A1_0613
1.7.11|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][OH:4].[CH3:5][c:6]1[cH:7][n:8][c:9]([c:10]([n:11]1)Br)[NH2:12]>CO.Clc1nccnc1Cl>[CH3:1][CH2:2][CH2:3][O:4][c:10]1[n:11][c:6]([cH:7][n:8][c:9]1[NH2:12])[CH3:5]|US08987445B2_0521
2.6.2|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH:2]([CH3:3])[CH:4]([C:5](=[O:6])[OH:7])[c:8]1[cH:9][c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[s:16]1)[Cl:17].[N:18]#[C:19][CH:20](Cl)[c:21]1[cH:22][cH:23][cH:24][c:25]([cH:26]1)[O:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>CCOCC.CS(C)=O.[O-]C([O-])=O.ClCCl.C1CCOC1.[K+].[K+]>[CH3:1][CH:2]([CH3:3])[CH:4]([C:5](=[O:6])[O:7][CH:20]([C:19]#[N:18])[c:21]1[cH:22][cH:23][cH:24][c:25]([cH:26]1)[O:27][c:28]1[cH:33][cH:32][cH:31][cH:30][cH:29]1)[c:8]1[cH:9][c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[s:16]1)[Cl:17]|US20050282819A1_0210
1.8.13|[C:5]=[C&H0&+0&D3:4](-[c:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[C:5]=[C&H0&+0&D3:4](-[S&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][C:2]1=[N:3][NH:4][C:5](/[C:6]1=[C:7]1[CH:8]=[C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[NH:16]/1)Cl)=[O:17].[SH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>CCO>[CH3:1][C:2]1=[N:3][NH:4][C:5](/[C:6]1=[C:7]1[CH:8]=[C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[NH:16]/1)[S:18][c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1)=[O:17]|US07550598B2_0667
1.7.9|[C:5]-[C&H1&+0&D3:4](-[c:3])-Br.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|[N:1]#[C:2][CH:3](Br)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10].[OH:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21]>O=C(O[K])O[K].ClCCl>[N:1]#[C:2][CH:3]([O:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10]|US08809579B2_0235
1.6.4|[C:5]=[N&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[NH:3])[NH:4][S:5](=[O:6])(=[O:7])[c:8]1[cH:9][c:10]([cH:11][c:12]([cH:13]1)[I:14])[C:15]#[N:16].Cl[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>Nc1ccccc1>[CH3:1][C:2](=[N:3][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1)[NH:4][S:5](=[O:6])(=[O:7])[c:8]1[cH:9][c:10]([cH:11][c:12]([cH:13]1)[I:14])[C:15]#[N:16]|US20190152949A1_0625
1.7.9|[C:5]-[O&H1&+0&D1:4].[N:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H1&+0&D3:2](-[N:3])-[c:1]|[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[OH:8].[O:9]=[C:10]1[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[CH:17]([N:18]1[c:19]1[cH:20][cH:21][c:22]2[cH:23][cH:24][c:25]([n:26][c:27]2[n:28]1)[Cl:29])Cl>[NaH]>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[O:8][CH:17]1[c:16]2[cH:15][cH:14][cH:13][cH:12][c:11]2[C:10]([N:18]1[c:19]1[cH:20][cH:21][c:22]2[cH:23][cH:24][c:25]([n:26][c:27]2[n:28]1)[Cl:29])=[O:9]|US05102890A
1.8.12|[C:5]-[C&H1&+0&D3:4](-[c:3])-Br.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[S&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][O:2][C:3](=[O:4])[CH:5](Br)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19].[SH:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[Cl:27]>CO>[CH3:1][O:2][C:3](=[O:4])[CH:5]([S:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[Cl:27])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19]|US20200347022A1_0651
1.3.7|[C:5]-[C&H0&+0&D3:4](=[C:3])-Cl.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[C:3])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[Br:8].[O:9]=[C:10]1[NH:11][C:12]([C:13](=[C:14]1Cl)[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[Cl:21])=[O:22]>CO>[O:22]=[C:12]1[NH:11][C:10]([C:14](=[C:13]1[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[Cl:21])[NH:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[Br:8])=[O:9]|US20100016321A1_1019
1.8.13|[C:5]-[C&H1&+0&D3:4](-[C:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][C:4](=[O:5])[CH:6](Cl)[CH2:7][CH3:8].[CH3:9][c:10]1[cH:11][c:12]([c:13]([o:14]1)[CH3:15])[SH:16]>O.[Na+].C[O-].CO>[CH3:9][c:10]1[cH:11][c:12]([c:13]([o:14]1)[CH3:15])[S:16][CH:6]([CH2:7][CH3:8])[C:4](=[O:5])[CH2:3][CH2:2][CH3:1]|US20180265467A1_0471
1.7.9|[C:5]-[C&H1&+0&D3:4](-[S:3])-Br.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[S:3]|[OH:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[cH:11]1.[O:12]=[C:13]1[NH:14][C:15]([CH:16]([S:17]1)Br)=[O:18]>C[Si](C)(C)[N-][Si](C)(C)C.C1CCOC1.ClC(Cl)Cl.CC#N.[Li+]>[O:12]=[C:13]1[NH:14][C:15]([CH:16]([S:17]1)[O:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[cH:11]1)=[O:18]|US08148407B2_0179
1.7.9|[C:5]-[C&H1&+0&D3:4](-[C:3])-Br.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:2]-[c:1]|[OH:1][CH2:2][C@:3]12[CH2:4][CH2:5][C@@H:6]3[c:7]4[cH:8][cH:9][c:10]([cH:11][c:12]4[CH2:13][CH2:14][C@H:15]3[C@@H:16]1[CH2:17][CH2:18][C@@H:19]2[OH:20])[OH:21].Br[CH:22]1[CH2:23][CH2:24][CH2:25][CH2:26]1>CCO.O=C(O[K])O[K]>[OH:1][CH2:2][C@:3]12[CH2:4][CH2:5][C@@H:6]3[c:7]4[cH:8][cH:9][c:10]([cH:11][c:12]4[CH2:13][CH2:14][C@H:15]3[C@@H:16]1[CH2:17][CH2:18][C@@H:19]2[OH:20])[O:21][CH:22]1[CH2:23][CH2:24][CH2:25][CH2:26]1|EP1852433B1_0357
1.6.2|[C:5]-[C&H1&+0&D3:4](-[c:3])-Br.[C:2]-[N&H2&+0&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])-[c:3]|[CH3:1][CH2:2][CH:3]1[CH:4]=[CH:5][C:6]2[C:7]([c:8]3[c:9]([C:10]([C:11]=2[C:12]11[O:13][CH2:14][CH2:15][O:16]1)=[O:17])[c:18]([c:19]1[CH2:20][CH:21]([CH2:22][CH:23]([c:24]1[c:25]3[OH:26])Br)[OH:27])[OH:28])=[O:29].[NH2:30][CH2:31][CH2:32][OH:33]>>[CH3:1][CH2:2][CH:3]1[CH:4]=[CH:5][C:6]2=[C:11]([C:10]([c:9]3[c:8]([C:7]2=[O:29])[c:25]([c:24]2[c:19]([CH2:20][CH:21]([CH2:22][CH:23]2[NH:30][CH2:31][CH2:32][OH:33])[OH:27])[c:18]3[OH:28])[OH:26])=[O:17])[C:12]11[O:13][CH2:14][CH2:15][O:16]1|US04545936A
1.6.4|[C:5]-[N&H2&+0&D1:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[c:3])-[c:1]|Cl[CH:1]1[c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[O:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21.[CH3:15][N:16]([CH3:17])[NH:18][C:19]([NH2:20])=[O:21]>c1ccccc1.C1COCCO1.O=C(O)O[Na].O.O.[NaH]>[CH3:15][N:16]([CH3:17])[NH:18][C:19](=[O:21])[NH:20][CH:1]1[c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[O:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21|US20190292188A1_1109
1.8.13|[C:5]-[S&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[o:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[o:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][SH:7].Cl[c:8]1[n:9][c:10]([n:11][o:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>O.[Na+].C[O-].CO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][S:7][c:8]1[n:9][c:10]([n:11][o:12]1)-[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|US20190367499A1_0193
1.6.4|[C:5]=[N&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[F:15][c:16]1[cH:17][cH:18][cH:19][n:20][c:21]1Cl>c1ccc(cc1)P(c1ccccc1)c1ccc2ccccc2c1-c1c2ccccc2ccc1P(c1ccccc1)c1ccccc1.CC(=O)O[Pd]OC(C)=O.Cc1ccccc1.[O-]C([O-])=O.[Cs+].[Cs+]>[F:15][c:16]1[cH:17][cH:18][cH:19][n:20][c:21]1[N:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US20200207738A1_0163
1.7.11|[O&H0&-&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.F[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14].[K+]>O.CN1CCCC1=O>[Cl:14][c:11]1[cH:12][cH:13][c:8]([cH:9][cH:10]1)[O:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1|EP0905123A1_0052
1.7.9|[C:5]-[C&H1&+0&D3:4](-[C:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[o:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[c:13]1[C:14](=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[OH:22].[CH3:23][C:24]([CH3:25])([CH3:26])[N:27]1[CH2:28][CH:29]([CH2:30]1)Cl>CCO.O[Na]>[CH3:23][C:24]([CH3:25])([CH3:26])[N:27]1[CH2:28][CH:29]([CH2:30]1)[O:22][c:19]1[cH:18][cH:17][c:16]([cH:21][cH:20]1)[C:14](=[O:15])[c:13]1[c:5]([o:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21)[CH2:4][CH2:3][CH2:2][CH3:1]|US20200069648A1_0418
9.7.58|[S&H1&-&D0:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[S&H0&+0&D1:4]=[C&H0&+0&D3:2](-[N&H2&+0&D1:3])-[c:1]|[Na+].[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[OH:9].[SH-:10]>O>[NH2:1][C:2](=[S:10])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[OH:9]|US20190142799A1_0474
1.7.9|[C:5]-[C&H1&+0&D3:4](-[O:3])-Br.[C:2]-[O&H1&+0&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[O:3]|[CH3:1][N:2]([CH3:3])[C:4]1[O:5][CH:6]([C:7]([C:8]=1[c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[C:15]([F:16])([F:17])[F:18])=[O:19])Br.[CH3:20][CH2:21][OH:22]>>[CH3:20][CH2:21][O:22][CH:6]1[O:5][C:4](=[C:8]([C:7]1=[O:19])[c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[C:15]([F:16])([F:17])[F:18])[N:2]([CH3:1])[CH3:3]|US20140370501A1_0334
1.1.7|[C&H3&+0&D1:5]-I.[C:4]-[N&H0&+0&D3:3](-[C:2])-[C:1]>>[C&H3&+0&D1:5]-[N&H0&+&D4:3](-[C:4])(-[C:2])-[C:1]|[CH3:1]I.[O:2]=[C:3]1[CH2:4][CH2:5][N:6]([CH2:7][CH2:8]1)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>>[CH3:1][N+:6]1([CH2:5][CH2:4][C:3]([CH2:8][CH2:7]1)=[O:2])[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|
9.7.165|[N&H3&+0&D0:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C@@:2]12[CH2:3][CH2:4][C@H:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@:14]1([C@H:15]2[CH2:16][CH2:17][C@@H:18]1[C:19](=[O:20])Cl)[CH3:21])=[O:22])[O:23][N+:24]([O-:25])=[O:26].[NH3:27]>c1ccccc1.O>[CH3:1][C@@:2]12[CH2:3][CH2:4][C@H:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@@:14]1([C@H:18]([CH2:17][CH2:16][C@@H:15]21)[C:19]([NH2:27])=[O:20])[CH3:21])=[O:22])[O:23][N+:24]([O-:25])=[O:26]|US20190322665A1_0941
1.7.11|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH2:3][CH2:4][OH:5])[CH2:6][CH2:7][OH:8].[NH2:9][c:10]1[c:11]2[C:12]([c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3[C:19]([c:20]2[c:21]([cH:22][c:23]1Cl)[OH:24])=[O:25])=[O:26]>CN1CCCC1=O.O=C(O[K])O[K].Oc1ccccc1>[CH3:1][CH:2]([CH2:3][CH2:4][OH:5])[CH2:6][CH2:7][O:8][c:23]1[cH:22][c:21]([c:20]2[C:19]([c:18]3[cH:17][cH:16][cH:15][cH:14][c:13]3[C:12]([c:11]2[c:10]1[NH2:9])=[O:26])=[O:25])[OH:24]|US05756517A
1.8.13|[C:5]-[S&H1&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][C:5](=[O:6])[CH:7]([SH:8])[CH:9]([CH3:10])[CH3:11].[CH3:12][CH2:13][CH:14](Cl)[C:15](=[O:16])[CH2:17][CH2:18][CH3:19]>O.[Na+].C[O-].CO>[CH3:1][CH:2]([CH3:3])[CH2:4][C:5](=[O:6])[CH:7]([S:8][CH:14]([CH2:13][CH3:12])[C:15](=[O:16])[CH2:17][CH2:18][CH3:19])[CH:9]([CH3:10])[CH3:11]|US10870623B2_0388
1.8.13|[C:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]1=[C:6]([N:7]([C:8](=[C:9]([CH:10]1[c:11]1[cH:12][c:13]([cH:14][cH:15][c:16]1Cl)[N+:17]([O-:18])=[O:19])[C:20](=[O:21])[O:22][CH3:23])[CH3:24])[CH3:25])[CH3:26].[CH3:27][CH2:28][O:29][C:30](=[O:31])[CH2:32][SH:33]>CCOCC.[Na]>[CH3:23][O:22][C:20](=[O:21])[C:9]1=[C:8]([N:7]([C:6](=[C:5]([CH:10]1[c:11]1[cH:12][c:13]([cH:14][cH:15][c:16]1[S:33][CH2:32][C:30](=[O:31])[O:29][CH2:28][CH3:27])[N+:17]([O-:18])=[O:19])[C:3](=[O:4])[O:2][CH3:1])[CH3:26])[CH3:25])[CH3:24]|EP3066093B1_0235
1.3.7|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]1=[C:6]([NH:7][C:8](=[C:9]([CH:10]1[c:11]1[cH:12][cH:13][c:14]([c:15]([cH:16]1)[N+:17]([O-:18])=[O:19])Cl)[C:20](=[O:21])[O:22][CH3:23])[CH3:24])[CH3:25].[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH2:32][NH2:33]>CCOCC>[CH3:23][O:22][C:20](=[O:21])[C:9]1=[C:8]([NH:7][C:6](=[C:5]([CH:10]1[c:11]1[cH:12][cH:13][c:14]([c:15]([cH:16]1)[N+:17]([O-:18])=[O:19])[NH:33][CH2:32][CH2:31][N:28]([CH2:29][CH3:30])[CH2:27][CH3:26])[C:3](=[O:4])[O:2][CH3:1])[CH3:25])[CH3:24]|US08986656B2_0100
9.7.181|[N&H4&+&D0:4].[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](-[C:3])=[N&H1&+0&D1:1]|[NH4+:1].[Cl-].[ClH:2].[N:3]#[C:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>CO.CCO.ClCCl>[ClH:2].[NH:3]=[C:4]([NH2:1])[CH2:5][CH2:6][CH2:7][O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US20140256756A1_0398
1.8.12|[C:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][SH:10].[NH2:11][C:12](=[O:13])[c:14]1[n:15][cH:16][cH:17][cH:18][c:19]1Br>O.CS(C)=O.[NaH]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][S:10][c:19]1[cH:18][cH:17][cH:16][n:15][c:14]1[C:12]([NH2:11])=[O:13]|EP3512833B1_0052
9.7.128|[N&H4&+&D0:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[NH4+:1].[CH3:2][CH2:3][O:4][N:5]=[C:6]([C:7](=[O:8])OC)[C:9](=[O:10])[O:11][CH3:12].[OH-]>Cl.CO>[CH3:2][CH2:3][O:4][N:5]=[C:6]([C:9](=[O:10])[O:11][CH3:12])[C:7]([NH2:1])=[O:8]|US05438118A
1.8.12|[C:5]-[C&H1&+0&D3:4](-[S:3])-Br.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[S&H0&+0&D2:2]-[c:1])-[S:3]|[O:1]=[C:2]1[NH:3][C:4]([CH:5]([S:6]1)Br)=[O:7].[SH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][n:14]1>C[Si](C)(C)[N-][Si](C)(C)C.C1CCOC1.[Li+]>[O:1]=[C:2]1[NH:3][C:4]([CH:5]([S:6]1)[S:8][c:9]1[cH:10][cH:11][cH:12][cH:13][n:14]1)=[O:7]|US05101048A
1.6.4|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[NH2:1][CH2:2][CH2:3][NH:4][CH:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[CH3:18][O:19][C:20](=[O:21])[CH:22](Cl)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>CCN(CC)CC.CC#N>[CH3:18][O:19][C:20](=[O:21])[CH:22]([NH:1][CH2:2][CH2:3][NH:4][CH:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|US10550123B2_1158
1.7.11|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]([CH3:3])[CH2:4][c:5]1[cH:6][c:7]([cH:8][s:9]1)Br.[OH:10][CH2:11][CH2:12][CH2:13][OH:14]>Cl.O=[Cu].I[Na].[NaH]>[CH3:1][N:2]([CH3:3])[CH2:4][c:5]1[cH:6][c:7]([cH:8][s:9]1)[O:10][CH2:11][CH2:12][CH2:13][OH:14]|US10221173B2_1107
1.8.12|[C:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([n:7]1)Br.[O:8]=[C:9]([OH:10])[CH2:11][CH2:12][CH2:13][SH:14]>CCOCCO.[NaH]>[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([n:7]1)[S:14][CH2:13][CH2:12][CH2:11][C:9](=[O:8])[OH:10]|EP3617203A1_0229
1.3.6|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][NH2:5].[CH3:6][CH:7]([CH3:8])[NH:9][c:10]1[cH:11][cH:12][c:13]([c:14]2[C:15]([c:16]3[c:17]([cH:18][cH:19][cH:20][c:21]3[C:22]([c:23]12)=[O:24])[OH:25])=[O:26])Br>CO.[O-]S([O-])(=O)=O.Cl[Cu].[Cu+2]>[CH3:6][CH:7]([CH3:8])[NH:9][c:10]1[cH:11][cH:12][c:13]([c:14]2[C:15]([c:16]3[c:17]([cH:18][cH:19][cH:20][c:21]3[C:22]([c:23]21)=[O:24])[OH:25])=[O:26])[NH:5][CH2:4][CH:2]([CH3:1])[CH3:3]|US08163773B2_0682
1.3.7|[C:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][NH:7][c:8]1[cH:9][c:10]([n:11][c:12]([n:13]1)Cl)[Cl:14].[NH2:15][CH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23]>CCO.O=C(O[Na])O[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][NH:7][c:8]1[cH:9][c:10]([n:11][c:12]([n:13]1)[NH:15][CH2:16][c:17]1[cH:22][cH:21][c:20]([cH:19][cH:18]1)[Cl:23])[Cl:14]|US10059690B2_0777
1.8.13|[C:5]-[C&H1&+0&D3:4](-[O:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[O:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][C:2]1[C:3]([O:4][CH:5]([C:6]=1[CH3:7])Cl)=[O:8].[SH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16]>CC(C)=O.O=C(O[K])O[K]>[CH3:1][C:2]1[C:3]([O:4][CH:5]([C:6]=1[CH3:7])[S:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16])=[O:8]|US20200347089A1_0425
1.7.11|[C:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][OH:7].[Cl:8][c:9]1[cH:10][c:11]([n:12][c:13]([n:14]1)Cl)[NH:15][CH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23]>[Na+].C1CCOC1.[H-]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][O:7][c:13]1[n:12][c:11]([cH:10][c:9]([n:14]1)[Cl:8])[NH:15][CH2:16][c:17]1[cH:22][cH:21][c:20]([cH:19][cH:18]1)[Cl:23]|US07262212B2_2202
1.3.7|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][S:7][c:8]1[cH:9][c:10]([n:11][cH:12][n:13]1)Cl.[NH2:14][CH2:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22]>CCO.O=C(O[Na])O[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][S:7][c:8]1[cH:9][c:10]([n:11][cH:12][n:13]1)[NH:14][CH2:15][c:16]1[cH:21][cH:20][c:19]([cH:18][cH:17]1)[Cl:22]|US06544997B1
1.8.13|[C:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][SH:7].Cl[c:8]1[cH:9][c:10]([n:11][c:12]([n:13]1)[NH:14][CH2:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22])[Cl:23]>CCO.O=C(O)O[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][S:7][c:8]1[cH:9][c:10]([n:11][c:12]([n:13]1)[NH:14][CH2:15][c:16]1[cH:21][cH:20][c:19]([cH:18][cH:17]1)[Cl:22])[Cl:23]|EP1322651B1_0060
1.7.11|[C:5]-[C&H0&+0&D3:4](=[C:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[C:3])-[O&H0&+0&D2:2]-[c:1]|[O:1]=[C:2]1[CH:3]=[C:4]([CH2:5][CH2:6][CH2:7]1)Cl.[OH:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[N:15]=[C:16]([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>CC(C)=O.O=C(O[K])O[K]>[O:1]=[C:2]1[CH:3]=[C:4]([CH2:5][CH2:6][CH2:7]1)[O:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[N:15]=[C:16]([c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|EP3029024A1_0053
1.7.11|[C:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][N:2]([CH2:3][C:4]([F:5])([F:6])[F:7])[C:8](=[O:9])[CH2:10][OH:11].Cl[c:12]1[n:13][n:14][c:15]([s:16]1)-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>CC#N.O[K]>[CH3:1][N:2]([CH2:3][C:4]([F:5])([F:6])[F:7])[C:8](=[O:9])[CH2:10][O:11][c:12]1[n:13][n:14][c:15]([s:16]1)-[c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|US10526345B2_0295
10.1.1|[Br&H0&+0&D1:4]-Br.[C&H3&D1:3]-[C&H2&+0&D2:2]-[c:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[n:7][c:8]([n:9]([c:10]([c:11]2[cH:12]1)=[O:13])-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[F:20])[CH2:21][CH3:22].[Br:23]Br>CC(=O)O.CC(=O)O[Na]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[n:7][c:8]([n:9]([c:10]([c:11]2[cH:12]1)=[O:13])-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[F:20])[CH:21]([CH3:22])[Br:23]|EP0159915A2_0067
2.3.9|[N&H3&+0&D0:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[NH3:1].[O:2]=[C:3]1[NH:4][CH2:5][CH2:6][N:7]1[C:8](=[O:9])Cl>C1CCOC1>[NH2:1][C:8](=[O:9])[N:7]1[CH2:6][CH2:5][NH:4][C:3]1=[O:2]|US20200231566A1_3522
1.7.11|[C:5]=[C&H0&+0&D3:4](-[c:3])-Br.[O&H1&+0&D1:2]-[c:1]>>[C:5]=[C&H0&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|[O:1]=[S:2]1[C:3](=[C:4]([c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)Br)[Br:19].[OH:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[O:27][CH2:28][CH2:29][N:30]1[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1>CC(C)(C)O[K].C1CCOC1>[O:1]=[S:2]1[C:3](=[C:4]([c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[O:11][CH2:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)[O:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[O:27][CH2:28][CH2:29][N:30]1[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1)[Br:19]|US10604506B2_1513
9.7.334|[c:4]:[n&H0&+0&D3:3](:[n&H0&+0&D2:2]:[n:1])-C-c1:c:c:c:c:c:1>>[c:4]:[n&H0&+0&D2:3]:[n&H1&+0&D2:2]:[n:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][O:8][c:9]1[cH:10][n:11][n:12][n:13]1Cc1ccccc1>Cl.CCO.[Pd]>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][O:8][c:9]1[cH:10][n:11][nH:12][n:13]1|US09073875B2_0257
1.7.11|[C:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][CH2:2][OH:3].[CH3:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][s:10][c:11]([n:12]1)Br>[Na]>[CH3:1][CH2:2][O:3][c:11]1[n:12][c:8]([cH:9][s:10]1)[NH:7][C:5]([CH3:4])=[O:6]|US20200131142A1_0541
2.6.2|[C:5]-[C&H1&+0&D3:4](-[C:3])-Br.[C:2]-[O&H1&+0&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])[OH:4].[CH3:5][CH2:6][O:7][C:8](=[O:9])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1=[CH:17][CH:18]([CH2:19][C:20]1=[O:21])Br>CO.CC([O-])=O.[Ag+]>[CH3:5][CH2:6][O:7][C:8](=[O:9])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1=[CH:17][CH:18]([CH2:19][C:20]1=[O:21])[O:4][C:2]([CH3:1])=[O:3]|US08796474B1_0086
1.6.2|[C:5]-[C&H1&+0&D3:4](-[C:3])-Br.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[OH:10].[O:11]=[C:12]1[O:13][CH2:14][CH2:15][CH:16]1Br>O.Cl.O=C(O[Na])O[Na]>[O:9]=[C:8]([OH:10])[c:7]1[cH:6][cH:5][cH:4][cH:3][c:2]1[NH:1][CH:16]1[CH2:15][CH2:14][O:13][C:12]1=[O:11]|US10112929B2_0847
1.7.9|[C:5]-[O&H1&+0&D1:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H1&+0&D3:2](-[c:3])-[c:1]|[F:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH:8](Cl)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[F:15].[CH3:16][C:17](=[O:18])[NH:19][CH2:20][CH2:21][OH:22]>O=C(O[K])O[K].c1ccccc1.O>[CH3:16][C:17](=[O:18])[NH:19][CH2:20][CH2:21][O:22][CH:8]([c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[F:15])[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[F:1]|US20140315881A1_1229
1.6.4|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH2:1]=[CH:2][CH2:3][NH2:4].[CH3:5][O:6][CH2:7][CH:8](Cl)[CH:9]=[O:10]>Cc1ccccc1>[CH2:1]=[CH:2][CH2:3][NH:4][CH:8]([CH:9]=[O:10])[CH2:7][O:6][CH3:5]|US08048878B2_1345
1.7.9|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[O:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O:1]|[CH3:1][CH2:2][C:3]([CH3:4])([CH3:5])[OH:6].[CH3:7][S:8](=[O:9])(=[O:10])[O:11][c:12]1[cH:13][cH:14][c:15]2[O:16][CH:17]([C:18]([c:19]2[cH:20]1)([CH3:21])[CH3:22])Cl>CCOCC>[CH3:1][CH2:2][C:3]([CH3:4])([CH3:5])[O:6][CH:17]1[O:16][c:15]2[cH:14][cH:13][c:12]([cH:20][c:19]2[C:18]1([CH3:21])[CH3:22])[O:11][S:8]([CH3:7])(=[O:9])=[O:10]|US04137401A
1.3.6|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][CH2:2][CH2:3][NH2:4].Br[c:5]1[cH:6][cH:7][cH:8][cH:9][n:10]1>c1ccncc1>[NH2:4][CH2:3][CH2:2][NH:1][c:5]1[cH:6][cH:7][cH:8][cH:9][n:10]1|EP2476677A1_0008
1.6.2|[C:5]-[C&H1&+0&D3:4](-[C:3])-Br.[C:2]-[N&H2&+0&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:1]-[C:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]1([CH2:10][CH2:11][C:12]([CH:13]([CH2:14]1)Br)=[O:15])[C:16]([NH2:17])=[O:18]>Cl.CO.CCO.COCCOC.CC(=O)O.COc1cccc(c1)C1(CCC(CC1)=O)C(N)=O.NC(=O)C1CCCCC1.O=S(=O)(O)O.BrBr.Br[Br-]Br.c1cc[nH+]cc1.C1CCOC1>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]12[CH2:10][CH2:11][C:12]([CH:13]([CH2:14]2)[NH:17][C:16]1=[O:18])=[O:15]|US04897483A
9.7.181|[N&H4&+&D0:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](=[N&H1&+0&D1:3])-[c:1]|[NH4+:1].[Cl-].[CH3:2][O:3][c:4]1[cH:5][c:6]([cH:7][c:8]([c:9]1[O:10][CH3:11])[O:12][CH3:13])[C@H:14]1[CH2:15][CH2:16][C@@H:17]([O:18]1)[c:19]1[cH:20][c:21]([c:22]([c:23]([cH:24]1)[O:25][CH3:26])[O:27][CH2:28][CH2:29][S:30][c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[C:37]#[N:38])[S:39](=[O:40])(=[O:41])[CH2:42][CH2:43][CH3:44]>[Na+].C[O-].CO>[CH3:44][CH2:43][CH2:42][S:39](=[O:40])(=[O:41])[c:21]1[cH:20][c:19]([cH:24][c:23]([c:22]1[O:27][CH2:28][CH2:29][S:30][c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[C:37](=[NH:38])[NH2:1])[O:25][CH3:26])[C@H:17]1[CH2:16][CH2:15][C@@H:14]([O:18]1)[c:6]1[cH:5][c:4]([c:9]([c:8]([cH:7]1)[O:12][CH3:13])[O:10][CH3:11])[O:3][CH3:2]|US20170355708A1_0401
1.7.11|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[o:1])-Br>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19].[O:20]=[C:21]([OH:22])[c:23]1[cH:24][o:25][c:26]([cH:27]1)Br>O.CC(=O)O.Cc1ccc(cc1)C.[NaH]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:19][c:26]1[cH:27][c:23]([cH:24][o:25]1)[C:21](=[O:20])[OH:22]|US09975867B2_0027
1.8.13|[C:5]-[C&H1&+0&D3:4](-[c:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[S&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH2:2][CH2:3][CH:4](Cl)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[O-:11][n+:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[SH:18]>O.CCO.[Na]>[CH3:1][CH2:2][CH2:3][CH:4]([S:18][c:17]1[cH:16][cH:15][cH:14][cH:13][n+:12]1[O-:11])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|US20190194166A1_10118
1.8.7|[S&H0&-&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[cH:10][c:11]([c:12]([c:13]([n:14]1)[Cl:15])[Cl:16])I.[NH2:17][c:18]1[n:19][c:20]([cH:21][n:22][c:23]1[S-:24])[Cl:25].[Na+]>CC1(c2cccc(c2Oc2c1cccc2P(c1ccccc1)c1ccccc1)P(c1ccccc1)c1ccccc1)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)N(CC)C(C)C.C1COCCO1.[Pd].[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[cH:10][c:11]([c:12]([c:13]([n:14]1)[Cl:15])[Cl:16])[S:24][c:23]1[n:22][cH:21][c:20]([n:19][c:18]1[NH2:17])[Cl:25]|US10308660B2_0531
1.3.6|[C:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[NH2:1][CH2:2][CH2:3][CH2:4][NH2:5].Br[c:6]1[n:7][n:8][cH:9][s:10]1>>[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[n:7][n:8][cH:9][s:10]1|US20200131142A1_0637
1.7.9|[C:5]-[C&H1&+0&D3:4](-[c:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|[N:1]#[C:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[OH:11].[N:12]#[C:13][CH:14](Cl)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CC(C)=O.O=C(O[K])O[K]>[N:1]#[C:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[O:11][CH:14]([C:13]#[N:12])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|EP1985297A1_0566
1.3.6|[C:5]-[C&H0&+0&D3:4](=[C:3])-Br.[C:2]-[N&H2&+0&D1:1]>>[C:5]-[C&H0&+0&D3:4](=[C:3])-[N&H1&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][CH:11]1[CH2:12][N:13]([CH2:14]1)[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[C@H:21]([CH3:22])[NH2:23].[O:24]=[C:25]1[CH:26]=[C:27]([CH2:28][O:29]1)Br>C1CCOC1>[CH3:1][CH2:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][CH:11]1[CH2:12][N:13]([CH2:14]1)[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[C@H:21]([CH3:22])[NH:23][C:27]1=[CH:26][C:25]([O:29][CH2:28]1)=[O:24]|US20180319749A1_0218
9.7.59|[Cl&H0&D1:4]-[C&H0&+0&D4:3](-[Cl&H0&D1:2])(-[c:1])-Cl>>[Cl&H0&D1:4]-[C&H1&+0&D3:3](-[Cl&H0&D1:2])-[c:1]|[Cl:1][c:2]1[cH:3][c:4]([cH:5][c:6]([n:7]1)[Cl:8])[C:9]([Cl:10])([Cl:11])Cl>O.Cl.CC(C)=O.Cl[Sn]Cl>[Cl:1][c:2]1[cH:3][c:4]([cH:5][c:6]([n:7]1)[Cl:8])[CH:9]([Cl:10])[Cl:11]|US05723613A
1.8.12|[C:5]-[S&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][c:7]([c:8]([c:9]([cH:10]1)[Cl:11])-[n:12]1[n:13][cH:14][c:15]([n:16]1)[CH2:17][SH:18])[Cl:19].[CH2:20]=[CH:21][CH2:22][n:23]1[c:24]([c:25]([n:26][c:27]1Br)[C:28]#[N:29])[C:30]#[N:31]>C1COCCO1.O[Na].O>[CH2:20]=[CH:21][CH2:22][n:23]1[c:24]([c:25]([n:26][c:27]1[S:18][CH2:17][c:15]1[cH:14][n:13][n:12]([n:16]1)-[c:8]1[c:9]([cH:10][c:5]([cH:6][c:7]1[Cl:19])[C:2]([F:1])([F:3])[F:4])[Cl:11])[C:28]#[N:29])[C:30]#[N:31]|EP3300500B1_0554
1.8.13|[C:5]-[C&H0&+0&D3:4](=[N:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[N:3])-[S&H0&+0&D2:2]-[c:1]|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[C:9]([N:10]1[CH:11]1[CH2:12][O:13][N:14]=[C:15]1Cl)=[O:16].[CH3:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[SH:24]>CCN(CC)CC.CCO>[CH3:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[S:24][C:15]1=[N:14][O:13][CH2:12][CH:11]1[N:10]1[C:9]([c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]2[C:2]1=[O:1])=[O:16]|US05670504A
1.8.12|[C:5]-[C&H0&+0&D3:4](=[C:3])-Br.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[C:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[SH:10].[O:11]=[C:12]1[O:13][C:14]([CH2:15][C:16](=[C:17]1Br)[OH:18])([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>ClCCl.C1CCNCC1>[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[S:10][C:17]1=[C:16]([CH2:15][C:14]([O:13][C:12]1=[O:11])([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[OH:18]|EP0729463B1_0200
1.8.13|[C:5]-[S&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][C:2]1([CH2:3][CH:4]([CH2:5][C:6]([NH:7]1)([CH3:8])[CH3:9])[NH:10][c:11]1[n:12][c:13]([n:14][c:15]([n:16]1)Cl)[NH:17][c:18]1[cH:19][c:20]([c:21]([c:22]([cH:23]1)[CH3:24])[OH:25])[C:26]([CH3:27])([CH3:28])[CH3:29])[CH3:30].[CH3:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][SH:39]>CO.O.[Na]>[CH3:24][c:22]1[cH:23][c:18]([cH:19][c:20]([c:21]1[OH:25])[C:26]([CH3:27])([CH3:28])[CH3:29])[NH:17][c:13]1[n:12][c:11]([n:16][c:15]([n:14]1)[S:39][CH2:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH3:31])[NH:10][CH:4]1[CH2:3][C:2]([NH:7][C:6]([CH2:5]1)([CH3:8])[CH3:9])([CH3:1])[CH3:30]|US20200102325A1_0606
1.7.9|[C:5]-[O&H1&+0&D1:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-Br>>[C:5]-[O&H0&+0&D2:4]-[C&H1&+0&D3:2](-[c:3])-[c:1]|[OH:1][CH2:2][CH:3]1[CH2:4][O:5][C:6]([O:7]1)([C:8]([F:9])([F:10])[F:11])[C:12]([F:13])([F:14])[F:15].Br[CH:16]([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>Cc1ccccc1.CO.[Na].[NaH]>[F:13][C:12]([F:14])([F:15])[C:6]1([O:5][CH2:4][CH:3]([O:7]1)[CH2:2][O:1][CH:16]([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1)[C:8]([F:9])([F:10])[F:11]|US20180339983A1_0537
1.8.12|[C:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][SH:15].[O:16]=[C:17]([OH:18])[c:19]1[cH:20][cH:21][c:22]([s:23]1)Br>[Na+].CO.C[O-].CC(=O)N(C)C>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][S:15][c:22]1[cH:21][cH:20][c:19]([s:23]1)[C:17](=[O:16])[OH:18]|US20130085157A1_0193
1.3.6|[C:5]-[C&H0&+0&D3:4](=[C:3])-Br.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])[C:4]([CH3:5])([C:6]#[N:7])[N:8]1[C:9]([CH:10]=[C:11]([C:12]1=[O:13])Br)=[O:14].[NH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[CH2:22][OH:23]>CCO>[CH3:1][CH:2]([CH3:3])[C:4]([CH3:5])([C:6]#[N:7])[N:8]1[C:9]([CH:10]=[C:11]([C:12]1=[O:13])[NH:15][c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[CH2:22][OH:23])=[O:14]|US20180319749A1_0236
2.6.2|[C:5]-[C&H1&+0&D3:4](-[c:3])-Br.[C:2]-[O&H1&+0&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[c:3]|[CH2:1]=[C:2]([CH3:3])[CH2:4][CH:5]([C:6](=[O:7])[OH:8])[CH:9]([CH3:10])[CH3:11].[N:12]#[C:13][CH:14](Br)[c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[O:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>O.CC(C)=O.O=C(O[K])O[K]>[CH2:1]=[C:2]([CH3:3])[CH2:4][CH:5]([C:6](=[O:7])[O:8][CH:14]([C:13]#[N:12])[c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[O:21][c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1)[CH:9]([CH3:10])[CH3:11]|US20040157891A1_0660
1.8.12|[C:5]-[C&H1&+0&D3:4](-[C:3])-Br.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[S&H0&+0&D2:2]-[c:1]|[SH:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.Br[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12]1>O=S(=O)(c1ccccc1)C1CCCC1>[cH:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[S:1][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12]1|US08497288B2_0196
1.6.4|[C:5]=[C&H0&+0&D3:4](-[c:3])-Cl.[N&H2&+0&D1:2]-[c:1]>>[C:5]=[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[c:3]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2/[C:9]([C:10]([NH:11][c:12]2[cH:13]1)=[O:14])=[C:15](/Cl)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[CH3:22][N:23]1[CH2:24][CH2:25][N:26]([CH2:27][CH2:28]1)[CH2:29][C:30](=[O:31])[N:32]([CH3:33])[c:34]1[cH:35][cH:36][c:37]([cH:38][cH:39]1)[NH2:40]>>[CH3:33][N:32]([C:30](=[O:31])[CH2:29][N:26]1[CH2:27][CH2:28][N:23]([CH2:24][CH2:25]1)[CH3:22])[c:34]1[cH:39][cH:38][c:37]([cH:36][cH:35]1)[NH:40]/[C:15](=[C:9]1\[C:10]([NH:11][c:12]2[cH:13][c:5]([cH:6][cH:7][c:8]12)[C:3](=[O:4])[O:2][CH3:1])=[O:14])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20200010455A1_0538
1.6.2|[C:5]=[N&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH3:15][O:16][c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)Br>c1ccc(cc1)P(c1ccccc1)c1ccccc1Oc1ccccc1P(c1ccccc1)c1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.Cc1ccccc1.CC(C)(C)O[Na].[Pd].[Pd]>[CH3:15][O:16][c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)[N:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1|EP3154976B1_0300
1.8.12|[C:5]-[S&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([SH:6])[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.Br[c:13]1[n:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[s:21]1>[Na+].CN(C)C=O.Clc1nc2ccccc2s1.[H-]>[CH3:1][O:2][C:3](=[O:4])[CH:5]([S:6][c:13]1[n:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[s:21]1)[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1|US20100120784A1_0402
1.8.13|[C:5]-[C&H0&+0&D3:4](=[C:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[C:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])/[CH:5]=[C:6](/Cl)[CH2:7][CH2:8][CH2:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[CH3:17][O:18][c:19]1[cH:20][c:21]([cH:22][cH:23][c:24]1[O:25][CH3:26])[SH:27]>CO.O=C(O[K])O[K]>[CH3:17][O:18][c:19]1[cH:20][c:21]([cH:22][cH:23][c:24]1[O:25][CH3:26])[S:27]/[C:6](=[CH:5]/[C:3](=[O:4])[O:2][CH3:1])[CH2:7][CH2:8][CH2:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US20140045689A1_0737
1.3.7|[C:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][CH2:2][CH2:3][CH2:4][NH2:5].[CH3:6][c:7]1[n:8][s:9][c:10]([n:11]1)Cl>CCO>[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][c:10]1[n:11][c:7]([n:8][s:9]1)[CH3:6]|US20190055217A1_0337
1.7.11|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[C:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[C:1]|[CH3:1][CH2:2][OH:3].[CH3:4][n:5]1[n:6][cH:7][c:8]2[C:9]([C:10](=[C:11]([C:12]([c:13]21)=[O:14])Cl)[N:15]([C:16]([CH3:17])=[O:18])[CH:19]([CH3:20])[CH3:21])=[O:22]>CC(C)N>[CH3:17][C:16](=[O:18])[N:15]([C:10]1[C:9]([c:8]2[cH:7][n:6][n:5]([c:13]2[C:12]([C:11]=1[O:3][CH2:2][CH3:1])=[O:14])[CH3:4])=[O:22])[CH:19]([CH3:20])[CH3:21]|EP2176222B1_0129
1.3.7|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[C:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[C:1]|[CH3:1][n:2]1[n:3][cH:4][c:5]2[C:6]([C:7](=[C:8]([C:9]([c:10]21)=[O:11])[Cl:12])Cl)=[O:13].[NH2:14][CH:15]1[CH2:16][CH2:17]1>CCO>[CH3:1][n:2]1[n:3][cH:4][c:5]2[C:6]([C:7](=[C:8]([C:9]([c:10]21)=[O:11])[Cl:12])[NH:14][CH:15]1[CH2:16][CH2:17]1)=[O:13]|US20120128630A1_0320
9.7.165|[N&H3&+0&D0:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH3:1].[NH2:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][c:8]([cH:9][c:10]([c:11]1[O:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[N+:19]([O-:20])=[O:21])[C:22](=[O:23])Cl>>[NH2:1][C:22](=[O:23])[c:8]1[cH:9][c:10]([c:11]([c:6]([cH:7]1)[S:3]([NH2:2])(=[O:4])=[O:5])[O:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[N+:19]([O-:20])=[O:21]|EP2043656B1_0078
1.3.7|[C:5]-[N&H2&+0&D1:4].[N:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[N:3])-[c:1]|[O:1]=[S:2]1([N:3]=[C:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21)Cl)=[O:11].[CH3:12][CH2:13][O:14][C:15](=[O:16])[CH2:17][CH2:18][CH2:19][NH2:20].Cl>CCN(CC)CC.C1COCCO1>[CH3:12][CH2:13][O:14][C:15](=[O:16])[CH2:17][CH2:18][CH2:19][NH:20][C:4]1=[N:3][S:2]([c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]12)(=[O:1])=[O:11]|US20200055875A1_0905
9.7.128|[N&H4&+&D0:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O-C>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH4+:1].CO[C:2](=[O:3])[c:4]1[cH:5][s:6][c:7]([nH:8]1)=[O:9].[OH-]>>[NH2:1][C:2](=[O:3])[c:4]1[cH:5][s:6][c:7]([nH:8]1)=[O:9]|EP3133075B1_0218
1.3.7|[C:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[o:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[o:1]|[NH2:1][CH2:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1.Cl[c:19]1[n:20][c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[o:27]1>CCN(CC)CC.CCO>[cH:9]1[cH:8][cH:7][c:6]([cH:11][c:10]1[CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[O:5][CH2:4][CH2:3][CH2:2][NH:1][c:19]1[n:20][c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[o:27]1|US07923470B2_0126
4.1.66|[C:5]-[C&H1&+0&D3:4](-[C:3]-[N&H1&+0&D2:2]-[C:1])-O>>[C:5]-[C&H1&+0&D3:4]1-[C:3]-[N&H0&+0&D3:2]-1-[C:1]|O[CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]1[NH:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)N=NC(=O)OCC.CCOCC>[cH:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[CH2:8][N:7]1[CH:6]2[CH2:5][CH2:4][CH2:3][CH2:2][CH:1]21|US08716333B2_0204
1.7.11|[C:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][OH:9].Br[c:10]1[n:11][cH:12][c:13]([cH:14][n:15]1)[Br:16]>>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][c:10]1[n:11][cH:12][c:13]([cH:14][n:15]1)[Br:16]|US09359359B2_1455
1.6.2|[C:5]-[C&H1&+0&D3:4](-[c:3])-Br.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH:2]1[CH2:3][CH2:4][CH:5]([c:6]2[n:7][cH:8][c:9]([c:10]([n:11]21)=[O:12])[C:13](=[O:14])[OH:15])Br.[NH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Br:23]>CO.CS(C)=O>[CH3:1][CH:2]1[CH2:3][CH2:4][CH:5]([c:6]2[n:7][cH:8][c:9]([c:10]([n:11]21)=[O:12])[C:13](=[O:14])[OH:15])[NH:16][c:17]1[cH:22][cH:21][c:20]([cH:19][cH:18]1)[Br:23]|US20200121647A1_0169
2.6.2|[C:5]-[O&H1&+0&D1:4].[O:3]-[C&H1&+0&D3:2](-[c:1])-Br>>[C:5]-[O&H0&+0&D2:4]-[C&H1&+0&D3:2](-[O:3])-[c:1]|[CH3:1][C:2]1([S:3][C@@H:4]2[C@@H:5]([C:6]([N:7]2[C@H:8]1[C:9](=[O:10])[OH:11])=[O:12])[NH2:13])[CH3:14].[O:15]=[C:16]1[O:17][CH:18]([c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]12)Br>CCN(CC)CC.CCOC(C)=O.CN(C)C=O>[CH3:1][C:2]1([S:3][C@@H:4]2[C@@H:5]([C:6]([N:7]2[C@H:8]1[C:9](=[O:10])[O:11][CH:18]1[O:17][C:16]([c:24]2[cH:23][cH:22][cH:21][cH:20][c:19]21)=[O:15])=[O:12])[NH2:13])[CH3:14]|EP0013617A1_0106
3.2.3|[C&H2&+0&D1:5]=[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C&H1&+0&D2:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[n:11]1[cH:12][c:13]([n:14][c:15]1[CH3:16])I.[CH2:17]=[CH:18][C:19](=[O:20])[N:21]([CH3:22])[CH3:23]>CCN(CC)CC.O=C(O[Na])O[Na].CC([O-])=O.CC([O-])=O.ClC(Cl)Cl.CC#N.[Pd+2]>[CH3:22][N:21]([CH3:23])[C:19](=[O:20])/[CH:18]=[CH:17]/[c:13]1[cH:12][n:11]([c:15]([n:14]1)[CH3:16])[S:8](=[O:9])(=[O:10])[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH3:1]|US20200029566A1_0747
1.6.4|[N&H1&-&D1:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH2:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[S:9](=[O:10])(=[O:11])[NH-:12].[CH3:13][O:14][c:15]1[cH:16][cH:17][cH:18][c:19]([c:20]1[CH2:21][c:22]1[c:23]([n:24][cH:25][n:26][c:27]1[Cl:28])Cl)[O:29][CH3:30].[K+]>Cl.CO.CN(C)C=O.CC(C)(C)[O-].[K+]>[CH2:1]=[CH:2][c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[S:9](=[O:10])(=[O:11])[NH:12][c:23]1[n:24][cH:25][n:26][c:27]([c:22]1[CH2:21][c:20]1[c:15]([cH:16][cH:17][cH:18][c:19]1[O:29][CH3:30])[O:14][CH3:13])[Cl:28]|US07585885B2_0598
3.9.12|[C:5]-[C&H1&+0&D2:4]=C.[C:3]-[C&H0&+0&D3:2](-[c:1])=C>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[c:1]|C=[CH:1][CH2:2][C@@H:3]([NH:4][C:5](=[O:6])[O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[C:15](=[O:16])[N:17]([CH2:18][C:19](=C)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[CH2:26][c:27]1[cH:28][cH:29][c:30]([cH:31][c:32]1[O:33][CH3:34])[O:35][CH3:36]>Cc1cc(c(c(c1)C)N1CCN(C1=[Ru](Cl)(Cl)(=Cc1ccccc1)[P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)c1c(cc(cc1C)C)C)C.ClCCl>[CH3:36][O:35][c:30]1[cH:29][cH:28][c:27]([c:32]([cH:31]1)[O:33][CH3:34])[CH2:26][N:17]1[CH2:18][C:19](=[CH:1][CH2:2][C@H:3]([C:15]1=[O:16])[NH:4][C:5](=[O:6])[O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US20190077809A1_0471
7.6.1|[c:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[O&H0&+0&D2:1]-C>>[c:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[O&H1&+0&D1:1]|C[O:1][CH:2]=[CH:3][c:4]1[cH:5][cH:6][cH:7][c:8]([c:9]1[F:10])[Br:11]>O.[Na+].CS(=O)(=O)O.O=C(O)O[Na].C1CCOC1.[BH4-]>[OH:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][cH:7][c:8]([c:9]1[F:10])[Br:11]|US10160762B2_0485
3.11.91|[C&H3&+0&D1:5]-I.[C:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[c:2])-[c:1]|[CH3:1]I.[O:2]=[C:3]1[NH:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[CH:11]1[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[Cl:18]>O.CC(C)=O.O=C(O[K])O[K]>[CH3:1][C:11]1([C:3]([NH:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[Cl:18])=[O:2])[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US20070105820A1_0711
1.6.8|[N&H1&+0&D1:5]=[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[N&H0&+0&D2:5](=[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][S:2]([CH3:3])(=[NH:4])=[O:5].[Br:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)I>>[CH3:1][S:2]([CH3:3])(=[O:5])=[N:4][c:11]1[cH:12][c:7]([cH:8][cH:9][cH:10]1)[Br:6]|US10053471B2_0199
10.4.3|[O&H2&+0&D0:4].[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[O&H1&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&+0&D1:3])-[c:1]|[OH2:1].[CH2:2]=[CH:3][c:4]1[cH:5][c:6]([cH:7][c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]21)[O:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[C:22](=[O:23])[O:24][CH3:25]>[Na+].Cl.OO.C1CCOC1.[OH-]>[CH3:25][O:24][C:22](=[O:23])[c:6]1[cH:7][c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[c:4]([cH:5]1)[CH:3]([CH3:2])[OH:1])[O:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20180237444A1_2397
9.7.181|[N&H3&+0&D0:4].[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](-[C:3])=[N&H1&+0&D1:1]|[NH3:1].[ClH:2].[N:3]#[C:4][CH2:5][c:6]1[n:7][o:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]12>Cl[Al](Cl)Cl>[ClH:2].[NH:3]=[C:4]([NH2:1])[CH2:5][c:6]1[n:7][o:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21|US10202360B2_0438
3.3.4|[C&H1&+0&D1:5]#[C:4].[C:3]-[C&H0&+0&D3:2](=[C:1])-I>>[C&H0&+0&D2:5](#[C:4])-[C&H0&+0&D3:2](-[C:3])=[C:1]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][n:8]1)[C:9]#[C:10]/[C:11]([CH2:12][CH2:13][CH3:14])=[C:15](/[C:16]#[C:17][c:18]1[cH:19][cH:20][c:21]([cH:22][n:23]1)[C:24]#[C:25]/[C:26]([CH2:27][CH2:28][CH3:29])=[C:30](/[C:31]#[C:32][c:33]1[cH:34][cH:35][c:36]([cH:37][n:38]1)[C:39]#[C:40][C:41]([CH3:42])([CH3:43])[OH:44])[CH2:45][CH2:46][CH2:47][CH3:48])[CH2:49][CH2:50][CH2:51][CH3:52].[CH3:53][CH:54]([CH3:55])[Si:56]([C:57]#[C:58][c:59]1[cH:60][cH:61][c:62]([cH:63][n:64]1)[C:65]#[C:66]/[C:67]([CH2:68][CH2:69][CH3:70])=[C:71](/I)[CH2:72][CH2:73][CH2:74][CH3:75])([CH:76]([CH3:77])[CH3:78])[CH:79]([CH3:80])[CH3:81]>>[CH3:48][CH2:47][CH2:46][CH2:45]/[C:30]([C:31]#[C:32][c:33]1[cH:34][cH:35][c:36]([cH:37][n:38]1)[C:39]#[C:40][C:41]([CH3:42])([CH3:43])[OH:44])=[C:26](\[C:25]#[C:24][c:21]1[cH:20][cH:19][c:18]([n:23][cH:22]1)[C:17]#[C:16]/[C:15]([CH2:49][CH2:50][CH2:51][CH3:52])=[C:11](/[C:10]#[C:9][c:6]1[cH:5][cH:4][c:3]([n:8][cH:7]1)[C:2]#[C:1]/[C:71]([CH2:72][CH2:73][CH2:74][CH3:75])=[C:67](/[C:66]#[C:65][c:62]1[cH:61][cH:60][c:59]([n:64][cH:63]1)[C:58]#[C:57][Si:56]([CH:76]([CH3:77])[CH3:78])([CH:79]([CH3:80])[CH3:81])[CH:54]([CH3:53])[CH3:55])[CH2:68][CH2:69][CH3:70])[CH2:12][CH2:13][CH3:14])[CH2:27][CH2:28][CH3:29]|US20100105700A1_0807
8.4.1|[N&H2&+0&D1:4]-[c:3].[O&H1&+0&D1:2]-[O&H1&+0&D1:1]>>[N&H0&+&D3:4](=[O&H0&+0&D1:2])(-[O&H0&-&D1:1])-[c:3]|[NH2:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16])[Cl:17].[OH:18][OH:19]>O=C(OC(=O)C(F)(F)F)C(F)(F)F.ClCCl>[O-:19][N+:1](=[O:18])[c:2]1[c:7]([cH:6][cH:5][cH:4][c:3]1[Cl:17])[C:8](=[O:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16]|US20200024309A1_2011
8.4.2|[C:5]-[P&H0&+0&D3:4](-[C:3])-[c:2].[O&H1&+0&D1:1]-O>>[C:5]-[P&H0&+0&D4:4](-[C:3])(=[O&H0&+0&D1:1])-[c:2]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[P:8]([C:9](=[O:10])[c:11]1[c:12]([cH:13][cH:14][cH:15][c:16]1[Cl:17])[Cl:18])[C:19](=[O:20])[c:21]1[c:22]([cH:23][cH:24][cH:25][c:26]1[Cl:27])[Cl:28])[CH3:29].[OH:30]O>CC#N.O=[PH3]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[P:8](=[O:30])([C:9](=[O:10])[c:11]1[c:12]([cH:13][cH:14][cH:15][c:16]1[Cl:17])[Cl:18])[C:19](=[O:20])[c:21]1[c:22]([cH:23][cH:24][cH:25][c:26]1[Cl:27])[Cl:28])[CH3:29]|US20200354389A1_0240
1.7.8|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][N:2]([CH2:3][c:4]1[cH:5][c:6]([cH:7][c:8]([cH:9]1)[C:10]([F:11])([F:12])[F:13])[C:14]([F:15])([F:16])[F:17])[C:18](=[O:19])[c:20]1[cH:21][n:22][c:23]([cH:24][c:25]1-[c:26]1[cH:27][cH:28][cH:29][cH:30][c:31]1[CH3:32])I.[N:33]#[C:34][c:35]1[cH:36][cH:37][cH:38][c:39]([cH:40]1)[OH:41]>COC(C)(C)C.O=C(O[K])O[K].c1ccncc1.[O-2].[Cu+].[Cu+]>[CH3:32][c:31]1[cH:30][cH:29][cH:28][cH:27][c:26]1-[c:25]1[cH:24][c:23]([n:22][cH:21][c:20]1[C:18](=[O:19])[N:2]([CH3:1])[CH2:3][c:4]1[cH:9][c:8]([cH:7][c:6]([cH:5]1)[C:14]([F:15])([F:16])[F:17])[C:10]([F:11])([F:12])[F:13])[O:41][c:39]1[cH:38][cH:37][cH:36][c:35]([cH:40]1)[C:34]#[N:33]|US08044049B2_1621
3.3.4|[C&H1&+0&D1:5]#[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][c:11]([cH:12][cH:13][c:14]1I)[Cl:15].[CH:16]#[C:17][CH2:18][N:19]1[C:20]([c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[C:27]1=[O:28])=[O:29]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCNCC.ClCCl.I[Cu].[Cl-].[Cl-].[Pd+2]>[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][c:11]([cH:12][cH:13][c:14]1[C:16]#[C:17][CH2:18][N:19]1[C:20]([c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[C:27]1=[O:28])=[O:29])[Cl:15]|EP3327000B1_0126
9.7.181|[N&H3&+0&D0:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](=[N&H1&+0&D1:3])-[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]=[CH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[NH3:17].[ClH:18]>CCOC(=N)c1ccc(cc1)C=Cc1ccccc1.N=C([O-])c1ccccc1.c1ccccc1.CCO.CO.Cl>[NH:1]=[C:2]([NH2:17])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]=[CH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[ClH:18]|US20200377508A1_0131
3.11.91|[C&H3&+0&D1:5]-I.[C:4]-[C&H1&+0&D3:3](-[N:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[N:2])-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[CH:16]1[C:17](=[O:18])[O:19][CH3:20].[CH3:21]I>CC(C)[N-]C(C)C.C1CCOC1.[Li+]>[CH3:20][O:19][C:17](=[O:18])[C:16]1([c:15]2[cH:14][cH:13][cH:12][cH:11][c:10]2[CH2:9][N:8]1[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[CH3:21]|US20170002025A1_0810
3.11.91|[C&H3&+0&D1:5]-I.[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH:7]([C:8]([c:9]2[c:10]([c:11]1[Cl:12])[Cl:13])=[O:14])[CH:15]([CH3:16])[CH3:17].[CH3:18]I>COCCOC.[NaH]>[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][C:7]([C:8]([c:9]2[c:10]([c:11]1[Cl:12])[Cl:13])=[O:14])([CH3:18])[CH:15]([CH3:16])[CH3:17]|US09765054B2_0544
3.11.16|[C:5]-[C&H2&+0&D2:4]-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[C:9]([N:10]1[CH2:11][CH2:12][CH2:13]I)=[O:14].[O-:15][N+:16](=[O:17])[c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)I>Cc1ccccc1P(c1ccccc1C)c1ccccc1C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CN(C)C=O.C[Si](C)(C)Cl.BrCCBr.[Zn].[Pd].[Pd]>[O-:15][N+:16](=[O:17])[c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[CH2:13][CH2:12][CH2:11][N:10]1[C:9]([c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]2[C:2]1=[O:1])=[O:14]|US10000432B2_0320
1.3.9|[N&H2&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-I>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][O:5][C:6](=[O:7])[NH:8][c:9]1[n:10][c:11]([c:12]([s:13]1)-[c:14]1[cH:15][cH:16][n:17][c:18]([n:19]1)I)-[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[NH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>Cc1ccc(cc1)S(=O)(=O)O.C1COCCO1>[CH3:1][CH:2]([CH3:3])[CH2:4][O:5][C:6](=[O:7])[NH:8][c:9]1[n:10][c:11]([c:12]([s:13]1)-[c:14]1[cH:15][cH:16][n:17][c:18]([n:19]1)[NH:26][c:27]1[cH:32][cH:31][cH:30][cH:29][cH:28]1)-[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US08541429B2_0718
9.7.225|[c:4]:[c&H0&+0&D3:3](:[c:2])-F.[S&H0&+0&D2:1](-[#11])-[#11]>>[c:4]:[c&H0&+0&D3:3](:[c:2])-[S&H1&+0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][c:10]([c:11]1F)[F:12].[S:13]([Na])[Na]>O.CCOC(C)=O.CN(C)C=O.O=C(O)CC(O)(CC(=O)O)C(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][c:10]([c:11]1[SH:13])[F:12]|US20190225638A1_0518
3.11.52|[C&H3&+0&D1:5]-I.[C:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[c:1]|[CH3:1][C:2](=[O:3])[CH:4]([C:5]#[N:6])[c:7]1[cH:8][cH:9][c:10]2[O:11][c:12]3[n:13][cH:14][cH:15][cH:16][c:17]3[CH2:18][c:19]2[cH:20]1.[CH3:21]I>CN(C)C=O.[Na]>[CH3:1][C:2](=[O:3])[C:4]([CH3:21])([C:5]#[N:6])[c:7]1[cH:8][cH:9][c:10]2[O:11][c:12]3[n:13][cH:14][cH:15][cH:16][c:17]3[CH2:18][c:19]2[cH:20]1|US03997574A
1.3.8|[N&H2&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-F>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[NH2:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[OH:8])[N:9]=[N:10][C:11](=[N:12][NH:13][c:14]1[cH:15][c:16]([cH:17][cH:18][c:19]1[C:20](=[O:21])[OH:22])[S:23](=[O:24])(=[O:25])[OH:26])[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[S:33](=[O:34])(=[O:35])[OH:36].[F:37][c:38]1[n:39][c:40]([n:41][c:42]([n:43]1)F)[F:44]>O[Na].O.Cl>[O:21]=[C:20]([OH:22])[c:19]1[cH:18][cH:17][c:16]([cH:15][c:14]1[NH:13][N:12]=[C:11]([N:10]=[N:9][c:6]1[cH:5][c:4]([cH:3][c:2]([c:7]1[OH:8])[NH:1][c:42]1[n:43][c:38]([n:39][c:40]([n:41]1)[F:44])[F:37])[S:33](=[O:34])(=[O:35])[OH:36])[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[S:23](=[O:24])(=[O:25])[OH:26]|US20070293484A1_0198
3.11.83|[C&H3&+0&D1:5]-I.[C:4]-[C&H1&+0&D3:3](-[C:2])-[O:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([O:7][CH3:8])[C:9](=[O:10])[O:11][CH2:12][CH3:13].[CH3:14]I>C1COCCOCCOCCOCCO1.CN(C)C=O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:14])([O:7][CH3:8])[C:9](=[O:10])[O:11][CH2:12][CH3:13]|US10118916B2_0832
9.5.4|[C:5]-[C&H1&+0&D3:4](-[c:3])-[C&H1&+0&D3:2](-[O:1])-O>>[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[O:1]|[CH3:1][CH2:2][O:3][c:4]1[cH:5][cH:6][c:7]([c:8]([c:9]1[F:10])[F:11])[CH:12]1[CH2:13][CH2:14][CH:15]([O:16][CH:17]1O)[CH:18]1[CH2:19][CH2:20][CH:21]([CH2:22][CH2:23]1)[CH2:24][CH2:25][CH3:26]>Cc1ccc(cc1)S(=O)(=O)O>[CH3:26][CH2:25][CH2:24][CH:21]1[CH2:22][CH2:23][CH:18]([CH2:19][CH2:20]1)[CH:15]1[CH2:14][CH2:13][C:12](=[CH:17][O:16]1)[c:7]1[cH:6][cH:5][c:4]([c:9]([c:8]1[F:11])[F:10])[O:3][CH2:2][CH3:1]|US06291721B1
9.7.110|[O&H0&+0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[O&H0&-&D1:4]-[S&H0&+0&D3:3](=[O&H0&D1:2])-[c:1]|[Na+].[Na+:1].[O-]C([O-])=O.[O:2]=[S:3](=[O:4])(Cl)[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11]>O.[Zn]>[Na+:1].[O-:2][S:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11]|US20090156642A1_0432
1.3.7|[N&H3&+&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Cl-].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[C:9]([NH2:10])=[O:11])[NH3+:12].[CH3:13][CH2:14][O:15][c:16]1[cH:17][c:18]([cH:19][cH:20][c:21]1-[c:22]1[cH:23][c:24]([n:25][cH:26][n:27]1)Cl)[F:28]>>[CH3:13][CH2:14][O:15][c:16]1[cH:17][c:18]([cH:19][cH:20][c:21]1-[c:22]1[cH:23][c:24]([n:25][cH:26][n:27]1)[NH:12][c:6]1[cH:5][cH:4][c:3]([c:8]([cH:7]1)[C:9]([NH2:10])=[O:11])[O:2][CH3:1])[F:28]|
8.4.2|[O&H1&+0&D1:5]-O.[c:4]-[P&H0&+0&D3:3](-[c:2])-[c:1]>>[O&H0&+0&D1:5]=[P&H0&+0&D4:3](-[c:4])(-[c:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[P:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[OH:24]O>O.[Na+].[Na+].Cl.CO.[O-]S([O-])=O>[CH3:10][O:9][c:8]1[cH:7][cH:6][c:5]([cH:4][c:3]1[O:2][CH3:1])[P:11](=[O:24])([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20200354389A1_0357
1.8.13|[S&H0&-&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][NH:2][c:3]1[c:4]([c:5]([cH:6][cH:7][c:8]1[N+:9]([O-:10])=[O:11])Cl)[Cl:12].[S-:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>CC#N>[CH3:1][NH:2][c:3]1[c:8]([cH:7][cH:6][c:5]([c:4]1[Cl:12])[S:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)[N+:9]([O-:10])=[O:11]|US10287266B2_0314
3.9.12|[C:5]-[C&H0&+0&D3:4](-[C:3])=C.[C:2]-[C&H1&+0&D2:1]=C>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:1]-[C:2]|C=[CH:1][CH2:2][N:3]([CH2:4][CH:5]([NH:6][C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[C:14](=C)[CH2:15][CH3:16])[C:17](=[O:18])[C:19]([F:20])([F:21])[F:22]>ClCCl.[Ru]>[CH3:16][CH2:15][C:14]1=[CH:1][CH2:2][N:3]([CH2:4][CH:5]1[NH:6][C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[C:17](=[O:18])[C:19]([F:20])([F:21])[F:22]|US20170313669A1_0359
9.7.161|[C:4]-[C&H2&+0&D2:3]-I.[N&H0&D1:2]#[C&H0&+0&D2:1]-[#11]>>[C:4]-[C&H2&+0&D2:3]-[C&H0&+0&D2:1]#[N&H0&D1:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[O:9][CH3:10])[CH2:11][N:12]1[C:13]([CH2:14][CH:15]1[CH2:16]I)=[O:17].[N:18]#[C:19][Na]>NC=O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[O:9][CH3:10])[CH2:11][N:12]1[C:13]([CH2:14][CH:15]1[CH2:16][C:19]#[N:18])=[O:17]|US06166216A
1.3.8|[N&H2&+0&D1:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[N&H1&+0&D2:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[S:4]([NH2:5])(=[O:6])=[O:7].[O-:8][N+:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1F)[C:17](=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>Cl.CS(C)=O.[NaH]>[CH3:1][CH:2]([CH3:3])[S:4](=[O:6])(=[O:7])[NH:5][c:16]1[cH:15][c:14]([cH:13][cH:12][c:11]1[N+:9]([O-:8])=[O:10])[C:17](=[O:18])[c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1|US20200407344A1_0897
1.7.11|[O&H0&-&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][N:2]1[C:3]([c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[C:10]1=[O:11])Cl)=[O:12].[O-:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[CH3:1][N:2]1[C:3]([c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[C:10]1=[O:11])[O:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)=[O:12]|EP0007482B1_0049
1.2.3|[N&H2&+0&D1:5]-[c:4].[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H0&+0&D2:5](-[c:4])=[C&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH2:6][N:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[C:14](=O)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[n:22][cH:23][cH:24][cH:25][c:26]1[NH2:27]>CC(=O)O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH2:6][N:7]1[c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[C:14](=[N:27][c:26]2[cH:25][cH:24][cH:23][n:22][c:21]21)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|EP0157656A2_0084
3.11.91|[C&H3&+0&D1:5]-I.[C:4]-[C&H1&+0&D3:3](-[C:2])-[S:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[S:1]|[CH3:1]I.[O:2]=[C:3]([OH:4])[CH:5]1[CH2:6][c:7]2[cH:8][cH:9][s:10][c:11]2[S:12]1(=[O:13])=[O:14]>CN(C)C=O.[NaH]>[CH3:1][C:5]1([CH2:6][c:7]2[cH:8][cH:9][s:10][c:11]2[S:12]1(=[O:13])=[O:14])[C:3](=[O:2])[OH:4]|US20200062743A1_0228
9.5.4|[C:5]-[C&H1&+0&D3:4](-[C&H1&+0&D3:3](-[C:2])-[C:1])-O>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[C:1]|[N:1]#[C:2][CH:3](O)[CH:4]1[CH2:5][CH2:6][CH:7]2[CH2:8][CH:9]21>O.O=S(Cl)Cl.c1ccncc1>[N:1]#[C:2][CH:3]=[C:4]1[CH2:5][CH2:6][CH:7]2[CH2:8][CH:9]12|US20110124634A1_0720
1.2.6|[N&H2&+0&D1:5]-[N:4].[c:3]:[c&H0&+0&D3:2](:[c:1])=O>>[N&H0&+0&D2:5](-[N:4])=[c&H0&+0&D3:2](:[c:3]):[c:1]|O.Cl.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([c:8]([c:9]([c:10]2[cH:11]1)=[O:12])=O)=[O:13].[NH2:14][NH:15][C:16](=[O:17])[NH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:10]([cH:11]1)[c:9]([c:8]([c:7]2=[O:13])=[N:14][NH:15][C:16](=[O:17])[NH:18][c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1)=[O:12]|US05648381A
3.3.4|[C&H1&+0&D1:5]#[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][S:7][c:8]1[n:9][n:10]2[c:11]([s:12]1)[n:13][c:14]([cH:15][c:16]2=[O:17])I.[CH:18]#[C:19][CH3:20]>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccccc1.CCN(CC)CC.C1CCOC1.I[Cu].O>[CH3:20][C:19]#[C:18][c:14]1[cH:15][c:16]([n:10]2[n:9][c:8]([s:12][c:11]2[n:13]1)[S:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH3:1])=[O:17]|EP2675793B1_0179
9.5.4|[C:5]-[C&H0&+0&D4:4](-[c:3])(-[C&H2&+0&D2:2]-[c:1])-O>>[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[c:1]|[CH3:1][N:2]([CH3:3])[CH2:4][C:5]#[C:6][C:7]1([CH2:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[S:15][c:16]2[cH:17][cH:18][c:19]([cH:20][c:21]21)[Cl:22])O>Cc1ccccc1C.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][N:2]([CH3:3])[CH2:4][C:5]#[C:6][C:7]1=[CH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[S:15][c:16]2[cH:17][cH:18][c:19]([cH:20][c:21]12)[Cl:22]|US20200392073A1_0425
9.5.4|[C:5]-[C&H1&+0&D3:4](-[C&H1&+0&D3:3](-[C:2])-[N:1])-O>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[N:1]|[CH3:1][O:2][N:3]=[C:4]([C:5](=[O:6])[NH:7][CH:8]1[C:9]([N:10]2[C@@H:11]1[S:12][CH2:13][CH:14]([CH:15]2[C:16](=[O:17])[OH:18])O)=[O:19])[C:20]([CH3:21])=[O:22]>O=C(OC(=O)C(F)(F)F)C(F)(F)F.CCN(CC)CC.CCOC(C)=O.C1CCOC1.O.Cl>[CH3:1][O:2][N:3]=[C:4]([C:20]([CH3:21])=[O:22])[C:5](=[O:6])[NH:7][CH:8]1[C:9]([N:10]2[C:15](=[CH:14][CH2:13][S:12][C@H:11]12)[C:16](=[O:17])[OH:18])=[O:19]|US06664412B2
3.11.37|[C&H1&+0&D1:4]#[C:3].[C&H2&+0&D1:2]=[O&H0&+0&D1:1]>>[C&H0&+0&D2:4](-[C&H2&+0&D2:2]-[O&H1&+0&D1:1])#[C:3]|[CH:1]#[C:2][C:3]1=[CH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[S:11][c:12]2[cH:13][cH:14][c:15]([cH:16][c:17]12)[Cl:18].[CH2:19]=[O:20]>[NH4+].[Cl-].CC[Mg]Br.C1CCOC1>[OH:20][CH2:19][C:1]#[C:2][C:3]1=[CH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[S:11][c:12]2[cH:13][cH:14][c:15]([cH:16][c:17]12)[Cl:18]|US20190300521A1_1238
10.1.9|[Cl&H1&+0&D0:4].[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[C:1]>>[Cl&H0&+0&D1:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[C:1]|[ClH:1].[CH2:2]=[CH:3][C:4](=[O:5])[C@H:6]1[CH2:7][CH2:8][C@H:9]2[C@@H:10]3[CH2:11][CH2:12][C@H:13]4[CH2:14][C@@H:15]([CH2:16][CH2:17][C@@:18]4([C@H:19]3[C:20]([CH2:21][C@@:22]21[CH3:23])=[O:24])[CH3:25])[OH:26]>O.C1COCCO1>[CH3:25][C@@:18]12[CH2:17][CH2:16][C@H:15]([CH2:14][C@@H:13]2[CH2:12][CH2:11][C@@H:10]2[C@@H:19]1[C:20]([CH2:21][C@@:22]1([C@H:6]([CH2:7][CH2:8][C@@H:9]21)[C:4](=[O:5])[CH2:3][CH2:2][Cl:1])[CH3:23])=[O:24])[OH:26]|US20180353480A1_0602
9.5.4|[C:5]-[C&H0&+0&D4:4](-[c:3])(-[C&H2&+0&D2:2]-[n:1])-O>>[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](O)([CH2:8][n:9]1[cH:10][n:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>Cl.ClC(Cl)Cl>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](=[CH:8][n:9]1[cH:13][cH:12][n:11][cH:10]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US20200377460A1_0689
9.5.4|[C:5]-[C&H2&+0&D2:4]-[C&H0&+0&D4:3](-[C:2])(-[c:1])-O>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]|[O:1]=[C:2]1[CH2:3][CH2:4][C:5]([CH2:6][CH2:7]1)(O)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[F:14]>O=C(O)O[Na].O=C(O)C(F)(F)F>[O:1]=[C:2]1[CH2:7][CH2:6][C:5](=[CH:4][CH2:3]1)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[F:14]|US20100298368A1_0480
1.8.14|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[N+:10]([O-:11])=[O:12])F.[CH3:13][C:14](=[O:15])[NH:16][CH2:17][CH2:18][n:19]1[n:20][n:21][n:22][c:23]1[SH:24]>CCN(CC)CC.CC(C)=O>[CH3:13][C:14](=[O:15])[NH:16][CH2:17][CH2:18][n:19]1[n:20][n:21][n:22][c:23]1[S:24][c:7]1[cH:6][cH:5][c:4]([cH:9][c:8]1[N+:10]([O-:11])=[O:12])[N+:2]([O-:1])=[O:3]|US10047051B2_1498
1.7.7|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-O>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7][c:8]([c:9]2[F:10])[OH:11])[nH:12]1.[CH3:13][c:14]1[c:15]2[c:16]([n:17][cH:18][n:19][n:20]2[cH:21][c:22]1[O:23][CH2:24][CH2:25][CH2:26][S:27]([CH3:28])(=[O:29])=[O:30])O>[Na+].CN(C)C=O.O=P(Cl)(Cl)Cl.ClCCl.[H-]>[CH3:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7][c:8]([c:9]2[F:10])[O:11][c:16]2[n:17][cH:18][n:19][n:20]3[cH:21][c:22]([c:14]([c:15]23)[CH3:13])[O:23][CH2:24][CH2:25][CH2:26][S:27]([CH3:28])(=[O:29])=[O:30])[nH:12]1|US20050065188A1_1176
1.7.11|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH:2]([O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[OH:10])[C:11](=[O:12])[OH:13].F[c:14]1[n:15][cH:16][c:17]([cH:18][c:19]1[F:20])[C:21]([F:22])([F:23])[F:24]>O=S(Cl)Cl.O[Na]>[CH3:1][CH:2]([O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][c:14]1[n:15][cH:16][c:17]([cH:18][c:19]1[F:20])[C:21]([F:22])([F:23])[F:24])[C:11](=[O:12])[OH:13]|US08232284B2_0758
9.7.11|[C:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-Cl)-Cl>>[C:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:1]=[O&H0&D1:2]|[CH3:1][O:2][CH:3]1[CH2:4][CH2:5][CH:6]([c:7]2[cH:8][cH:9][s:10][c:11]21)[NH2:12].[O:13]=[C:14](Cl)Cl>>[CH3:1][O:2][CH:3]1[CH2:4][CH2:5][CH:6]([c:7]2[cH:8][cH:9][s:10][c:11]21)[N:12]=[C:14]=[O:13]|US20140073589A1_0244
1.2.14|[N&H4&+&D0:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[N&H2&+0&D1:4]-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[NH4+:1].[CH2:2]([CH:3]1[CH2:4][O:5]1)[N:6]1[CH2:7][CH2:8][O:9][CH2:10][CH2:11]1.[OH-]>>[NH2:1][CH2:4][CH:3]([OH:5])[CH2:2][N:6]1[CH2:7][CH2:8][O:9][CH2:10][CH2:11]1|US20050101644A1_0756
9.5.4|[C:5]-[C&H1&+0&D3:4](-[C&H1&+0&D3:3](-[C:2])-[c:1])-O>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]|[CH3:1][NH:2][C:3](=[S:4])[CH:5]1[c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[O:12][C:13]([CH:14]1O)([CH3:15])[CH3:16])[C:17]#[N:18]>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][NH:2][C:3](=[S:4])[C:5]1=[CH:14][C:13]([O:12][c:11]2[cH:10][cH:9][c:8]([cH:7][c:6]12)[C:17]#[N:18])([CH3:15])[CH3:16]|EP0398665A1_0145
9.7.161|[C:4]-[C&H2&+0&D2:3]-I.[N&H0&D1:2]#[C&H0&+0&D2:1]-[#19]>>[C:4]-[C&H2&+0&D2:3]-[C&H0&+0&D2:1]#[N&H0&D1:2]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH2:6][CH2:7]I)[N:8]=[N+:9]=[N-:10].[N:11]#[C:12][K]>O.CS(C)=O>[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH2:6][CH2:7][C:12]#[N:11])[N:8]=[N+:9]=[N-:10]|US20070191353A1_0370
3.3.4|[C&H1&+0&D1:5]#[C:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-I>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[Cl:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)-[c:16]1[n:17][cH:18][c:19]([s:20]1)I>[NH4+].[Cl-].CCN(CC)CC.CC#N.I[Cu].[Pd+2]>[Cl:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)-[c:16]1[n:17][cH:18][c:19]([s:20]1)[C:1]#[C:2][c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1|US20200245624A1_0323
9.5.4|[c:5]-[C&H0&+0&D4:4](-[c:3])(-[C&H2&+0&D2:2]-[c:1])-O>>[c:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[c:1]|O[C:1]1([CH2:2][c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[O:9][c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]21)[Br:16])[c:17]1[cH:18][cH:19][n:20][cH:21][cH:22]1>O=C(O)C(F)(F)F>[Br:16][c:13]1[cH:12][cH:11][c:10]2[O:9][c:8]3[cH:7][cH:6][cH:5][cH:4][c:3]3[CH:2]=[C:1]([c:15]2[cH:14]1)[c:17]1[cH:18][cH:19][n:20][cH:21][cH:22]1|US20150202167A1_0034
9.5.4|[C&H3&+0&D1:4]-[C&H0&+0&D4:3](-[C&H3&D1:2])(-[C:1])-O>>[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C&H3&D1:2])-[C:1]|[CH3:1][C:2]([CH3:3])(O)[CH2:4][CH2:5][C:6]([Cl:7])([Cl:8])[Cl:9]>Cc1ccc(cc1)S(=O)(=O)O>[CH2:3]=[C:2]([CH3:1])[CH2:4][CH2:5][C:6]([Cl:7])([Cl:8])[Cl:9]|US09725400B2_0159
9.1.5|[Br&H1&+0&D0:4].[C&H3&D1:3]-[C&H1&+0&D3:2](-[c:1])-O>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[c:1]|[BrH:1].[CH3:2][CH:3](O)[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[CH2:10][OH:11]>CCC(=O)c1ccccc1C(=O)O.CCC(O)c1ccccc1CO.CC(C(=O)O)C(=O)O.O=C1OC(c2ccccc12)=O.ClCCl>[CH3:2][CH:3]([Br:1])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[CH2:10][OH:11]|US20110021471A1_0088
1.3.3|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|I[c:1]1[n:2][n:3][c:4]([c:5]2[c:6]1[cH:7][cH:8][cH:9][cH:10]2)[CH2:11][c:12]1[cH:13][cH:14][n:15][cH:16][cH:17]1.[CH3:18][c:19]1[cH:20][c:21]([n:22][c:23]([n:24]1)[CH3:25])[NH2:26]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccccc1.[O-]C([O-])=O.[K+].[K+]>[CH3:18][c:19]1[cH:20][c:21]([n:22][c:23]([n:24]1)[CH3:25])[NH:26][c:1]1[n:2][n:3][c:4]([c:5]2[c:6]1[cH:7][cH:8][cH:9][cH:10]2)[CH2:11][c:12]1[cH:13][cH:14][n:15][cH:16][cH:17]1|US20200010468A1_0851
1.3.9|[N&H2&+0&D1:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[N&H1&+0&D2:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[n:11]1)I)[N:12]1[CH2:13][CH2:14][CH2:15][CH2:16]1.[CH3:17][S:18]([NH2:19])(=[O:20])=[O:21]>O=C(O[Cs])O[Cs].C1COCCO1.ClCCl.I[Cu]>[CH3:1][c:2]1[cH:3][c:4]([c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[n:11]1)[NH:19][S:18]([CH3:17])(=[O:20])=[O:21])[N:12]1[CH2:13][CH2:14][CH2:15][CH2:16]1|US20200239441A1_0332
3.2.3|[C&H2&+0&D1:5]=[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C&H1&+0&D2:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[F:9])[c:10]1[cH:11][c:12]([cH:13][cH:14][c:15]1I)[Cl:16].[CH2:17]=[CH:18][C:19]#[N:20]>CC(=O)O[Pd]OC(C)=O.CCN(CC)CC.Cl>[N:20]#[C:19][CH:18]=[CH:17][c:15]1[cH:14][cH:13][c:12]([cH:11][c:10]1[C:2](=[O:1])[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[F:9])[Cl:16]|EP3484885B1_0096
3.9.50|[C:4]-[C&H1&+0&D2:3]=O.[I&H0&D1:2]-[C&H1&+0&D3:1](-I)-I>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:1]-[I&H0&D1:2]|O=[CH:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11].I[CH:12](I)[I:13]>O.[Cl-].[Cl-].C1CCOC1.[Cr+2]>[F:3][C:2]([F:4])([CH:1]=[CH:12][I:13])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11]|US04944795A
9.5.4|[C:5]-[C&H2&+0&D2:4]-[C&H0&+0&D4:3](-[C:2])(-[C:1])-O>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]([CH2:10][N:11]([CH3:12])[CH3:13])[C:14]1([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1)O>Cl.O[Na]>[CH3:1][O:2][c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[CH:9]([CH2:10][N:11]([CH3:12])[CH3:13])[C:14]1=[CH:19][CH2:18][CH2:17][CH2:16][CH2:15]1|US20020137664A1_0319
9.7.12|[C:4]-[N&H2&+0&D1:3].[S&H0&D1:2]=[C&H0&+0&D3:1](-Cl)-Cl>>[C:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:1]=[S&H0&D1:2]|[NH2:1][CH:2]1[CH:3]2[CH2:4][CH:5]3[CH:6]([CH2:7]2)[CH:8]31.[S:9]=[C:10](Cl)Cl>ClC(Cl)Cl>[S:9]=[C:10]=[N:1][CH:2]1[CH:3]2[CH2:4][CH:5]3[CH:6]([CH2:7]2)[CH:8]31|EP3419973B1_0419
1.2.5|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C:5]-[N&H1&+0&D2:4]-[C@@&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7][CH2:8][CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1.[CH3:15][C:16]([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[CH2:22][N:23]1[C:24]([C@H:25]([CH2:26][O:27][c:28]2[cH:29][cH:30][cH:31][cH:32][c:33]21)[NH2:34])=[O:35]>>[CH3:15][C:16]([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[CH2:22][N:23]1[C:24]([C@H:25]([CH2:26][O:27][c:28]2[cH:29][cH:30][cH:31][cH:32][c:33]21)[NH:34][C@H:6]([CH2:7][CH2:8][CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1])=[O:35]|US20130109682A1_0901
1.2.9|[N&H2&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-O>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][C@@H:2]([OH:3])[CH2:4][N:5]1[CH2:6][CH2:7][c:8]2[cH:9][c:10]([c:11]([cH:12][c:13]2[CH2:14][CH2:15]1)[NH2:16])[O:17][CH3:18].[O:19]=[S:20](=[O:21])([NH:22][CH:23]1[CH2:24][CH2:25]1)[c:26]1[cH:27][cH:28][cH:29][c:30]([cH:31]1)-[c:32]1[cH:33][cH:34][c:35]2[cH:36][n:37][c:38]([n:39][n:40]21)O>>[CH3:18][O:17][c:10]1[cH:9][c:8]2[CH2:7][CH2:6][N:5]([CH2:15][CH2:14][c:13]2[cH:12][c:11]1[NH:16][c:38]1[n:39][n:40]2[c:35]([cH:36][n:37]1)[cH:34][cH:33][c:32]2-[c:30]1[cH:29][cH:28][cH:27][c:26]([cH:31]1)[S:20](=[O:19])(=[O:21])[NH:22][CH:23]1[CH2:24][CH2:25]1)[CH2:4][C@@H:2]([CH3:1])[OH:3]|US08471005B2_1847
1.7.7|[O&H1&+0&D1:5]-[c:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-O>>[O&H0&+0&D2:5](-[c:4])-[C&H1&+0&D3:2](-[c:3])-[c:1]|O[CH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][s:10][c:11]([cH:12]1)-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[C:19]([F:20])([F:21])[F:22].[CH3:23][CH2:24][O:25][C:26](=[O:27])[C:28]([CH3:29])([CH3:30])[O:31][c:32]1[cH:33][cH:34][c:35]([cH:36][c:37]1[CH3:38])[OH:39]>CCOC(=O)COc1ccc(cc1C)SCc1cc(oc1)-c1ccc(cc1)C(F)(F)F>[CH3:23][CH2:24][O:25][C:26](=[O:27])[C:28]([CH3:29])([CH3:30])[O:31][c:32]1[cH:33][cH:34][c:35]([cH:36][c:37]1[CH3:38])[O:39][CH:1]([c:2]1[cH:7][cH:6][cH:5][cH:4][cH:3]1)[c:8]1[cH:9][s:10][c:11]([cH:12]1)-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[C:19]([F:20])([F:21])[F:22]|US20070111988A1_0184
1.8.15|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[SH:9].[CH3:10][O:11][c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)I)[C:18](=[O:19])[OH:20]>O.O[K].[Cu]>[CH3:10][O:11][c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[S:9][c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[S:2][CH3:1])[C:18](=[O:19])[OH:20]|US05883106A
2.5.7|[C:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-S-C>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|CS[c:1]1[n:2][c:3]([c:4]([c:5]([nH:6]1)=[O:7])[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[CH3:15].[CH3:16][c:17]1[n:18][cH:19][nH:20][c:21]1[CH2:22][S:23][CH2:24][CH2:25][NH2:26]>>[CH3:16][c:17]1[n:18][cH:19][nH:20][c:21]1[CH2:22][S:23][CH2:24][CH2:25][NH:26][c:1]1[n:2][c:3]([c:4]([c:5]([nH:6]1)=[O:7])[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[CH3:15]|EP0107914B1_0058
2.5.7|[C:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[N:1])-S-C>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[N:1]|CS[C:1]1=[N:2][CH2:3][CH2:4][S:5]([NH:6]1)(=[O:7])=[O:8].[CH3:9][c:10]1[n:11][cH:12][nH:13][c:14]1[CH2:15][S:16][CH2:17][CH2:18][NH2:19]>>[CH3:9][c:10]1[n:11][cH:12][nH:13][c:14]1[CH2:15][S:16][CH2:17][CH2:18][NH:19][C:1]1=[N:2][CH2:3][CH2:4][S:5]([NH:6]1)(=[O:7])=[O:8]|US20020119969A1_0156
9.7.242|[O&H0&-&D1:4]-Cl.[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-C>>[O&H1&+0&D1:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|C[C:1](=[O:2])[c:3]1[cH:4][n:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[c:12]1[OH:13])[CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1.[O-:20]Cl>C1COCCO1>[O:2]=[C:1]([OH:20])[c:3]1[cH:4][n:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[c:12]1[OH:13])[CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1|US10526337B2_0625
1.2.9|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-O>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][S:2][c:3]1[n:4][cH:5][c:6]2[n:7][cH:8][n:9][c:10]([c:11]2[n:12]1)O.[NH2:13][c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[Cl:20])[F:21]>Cc1ccc(cc1)S(=O)(=O)O.C[Si](C)(C)N[Si](C)(C)C.CO.O>[CH3:1][S:2][c:3]1[n:4][cH:5][c:6]2[n:7][cH:8][n:9][c:10]([c:11]2[n:12]1)[NH:13][c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[Cl:20])[F:21]|EP2586781A1_0153
3.11.31|[C:5]-[C&H2&+0&D2:4]-[N&+:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:5]-[C&H0&+0&D3:4](-[N&+:3])=[C&H1&+0&D2:1]-[c:2]|[CH3:1][CH2:2][CH2:3][N+:4]([O-:5])=[O:6].[CH3:7][N:8]([CH3:9])[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[Cl:16])[CH:17]=O>[NH4+].O.CC([O-])=O.CCCO>[CH3:7][N:8]([CH3:9])[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[Cl:16])[CH:17]=[C:3]([CH2:2][CH3:1])[N+:4]([O-:5])=[O:6]|US07915404B2_0274
1.7.7|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[CH2:9][c:10]1[cH:11][cH:12][c:13]([nH:14][n:15]1)=[O:16])[OH:17].[O-:18][N+:19](=[O:20])[c:21]1[cH:22][c:23]([cH:24][c:25]([c:26]1O)[Br:27])[CH:28]=[O:29]>CS(=O)(=O)Cl.c1ccncc1>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[CH2:9][c:10]1[cH:11][cH:12][c:13]([nH:14][n:15]1)=[O:16])[O:17][c:26]1[c:25]([cH:24][c:23]([cH:22][c:21]1[N+:19]([O-:18])=[O:20])[CH:28]=[O:29])[Br:27]|US09469634B2_1251
1.2.20|[C:5]=[C&H1&+0&D2:4]-O-C-C.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]=[C&H1&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|CCO[CH:1]=[C:2]([C:3](=[O:4])[O:5][CH2:6][CH3:7])[C:8](=[O:9])[O:10][CH2:11][CH3:12].[CH3:13][CH:14]([CH3:15])[NH:16][c:17]1[cH:18][cH:19][c:20]([c:21]([c:22]1[F:23])[F:24])[F:25]>CCCCCC>[CH3:7][CH2:6][O:5][C:3](=[O:4])[C:2](=[CH:1][N:16]([c:17]1[cH:18][cH:19][c:20]([c:21]([c:22]1[F:23])[F:24])[F:25])[CH:14]([CH3:13])[CH3:15])[C:8](=[O:9])[O:10][CH2:11][CH3:12]|EP2360160A1_0320
3.11.91|[C&H3&+0&D1:5]-I.[C:4]-[C&H1&+0&D3:3](-[C:2])-[N:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[N:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][NH:11][C:12]([CH:13]1[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)=[O:22].[CH3:23]I>ClCc1ccc(cc1)OCc1ccccc1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][NH:11][C:12]([C:13]1([CH3:23])[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)=[O:22]|US06756378B2
3.9.12|[C:5]-[C&H1&+0&D2:4]=C.[C:3]-[C&H0&+0&D3:2](-[O:1])=C>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[O:1]|C=[CH:1][CH2:2][C@@H:3]1[c:4]2[cH:5][c:6]([cH:7][cH:8][c:9]2[O:10][C:11]([C@H:12]1[CH2:13][C:14](=C)[O:15][CH2:16][O:17][CH3:18])=[O:19])[O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>Cc1cc(c(c(c1)C)N1CCN(C1[Ru](Cl)(Cl)(=Cc1ccccc1)[P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)c1c(cc(cc1C)C)C)C.ClCCl>[CH3:18][O:17][CH2:16][O:15][C:14]1=[CH:1][CH2:2][C@@H:3]2[c:4]3[cH:5][c:6]([cH:7][cH:8][c:9]3[O:10][C:11]([C@H:12]2[CH2:13]1)=[O:19])[O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|US09499482B2_0451
1.2.9|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|O[c:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[OH:7].[NH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>c1ccc(cc1)OP(Oc1ccccc1)Oc1ccccc1.O>[OH:7][c:4]1[cH:3][cH:2][c:1]([cH:6][cH:5]1)[NH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|EP2316820A1_0052
9.5.4|[C:5]-[C&H2&+0&D2:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-O>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH2:6][C:7]1([c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[C:14](=[CH:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21)[Br:22])O>O=C(OC(=O)C(F)(F)F)C(F)(F)F.O=C(O)C(F)(F)F>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH:6]=[C:7]1[c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[C:14](=[CH:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]12)[Br:22]|US03952017A
7.6.1|[C:5]-[C&H0&+0&D3:4](-[N&+:3])=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4](-[N&+:3])-[C&H2&+0&D2:2]-[c:1]|[NH2:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]2[O:9][CH2:10][C:11](=[CH:12][c:13]12)[N+:14]([O-:15])=[O:16])[F:17]>[Na+].CC(C)O.ClC(Cl)Cl.[BH4-]>[NH2:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]2[O:9][CH2:10][CH:11]([CH2:12][c:13]21)[N+:14]([O-:15])=[O:16])[F:17]|US20180222899A1_0281
9.7.58|[S&H0&-2&D0:4].[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[S&H0&+0&D1:4]=[C&H0&+0&D3:2](-[C:3])-[N&H2&+0&D1:1]|[NH4+].[NH4+].[CH3:1][c:2]1[n:3][c:4]([n:5][o:6]1)-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[NH:13][CH:14]([C:15]#[N:16])[c:17]1[cH:18][c:19]([c:20]([cH:21][c:22]1[F:23])[O:24][CH3:25])[O:26][CH3:27].[S-2:28]>O.CO.CC(=O)OCC.C1CCOC1>[CH3:27][O:26][c:19]1[cH:18][c:17]([c:22]([cH:21][c:20]1[O:24][CH3:25])[F:23])[CH:14]([NH:13][c:10]1[cH:11][cH:12][c:7]([cH:8][cH:9]1)-[c:4]1[n:5][o:6][c:2]([n:3]1)[CH3:1])[C:15]([NH2:16])=[S:28]|US20160214974A1_0589
1.3.8|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]2[O:6][CH2:7][O:8][c:9]2[cH:10]1.[O-:11][N+:12](=[O:13])[c:14]1[cH:15][cH:16][c:17]([n:18][c:19]1F)[F:20]>O.CCO.O=C(O)O[Na]>[O-:11][N+:12](=[O:13])[c:14]1[cH:15][cH:16][c:17]([n:18][c:19]1[NH:1][c:2]1[cH:3][cH:4][c:5]2[O:6][CH2:7][O:8][c:9]2[cH:10]1)[F:20]|US08362241B2_1839
3.11.2|[C&H3&+0&D1:5]-[C:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C&H1&+0&D2:5](-[C:4])=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][C:2](=[O:3])[CH2:4][CH2:5][CH2:6][C:7](=O)[c:8]1[cH:9][cH:10][c:11]([n:12][cH:13]1)[CH3:14]>O.CO.O[Na]>[CH3:14][c:11]1[cH:10][cH:9][c:8]([cH:13][n:12]1)[C:7]1=[CH:1][C:2]([CH2:4][CH2:5][CH2:6]1)=[O:3]|US20200360531A1_1195
1.7.11|[O&H0&-&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1Br)[N+:8]([O-:9])=[O:10])[N+:11]([O-:12])=[O:13].[O-:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[K+]>O.CN(C)C=O>[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[O:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1)[N+:8]([O-:9])=[O:10])[N+:11]([O-:12])=[O:13]|US06956042B2_0167
1.7.11|[O&H0&-&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Na+].[O-:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[Cl:8][c:9]1[n:10][cH:11][cH:12][n:13][c:14]1Cl>>[Cl:8][c:9]1[n:10][cH:11][cH:12][n:13][c:14]1[O:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1|US20180250303A1_0247
1.7.8|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)I.[OH:12][c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[F:19])[F:20]>O.O[K].[Cu]>[CH3:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[F:19])[F:20]|US20040186151A1_0979
1.2.6|[N&H2&+0&D1:5]-[S:4].[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H0&+0&D2:5](-[S:4])=[C&H0&+0&D3:2](-[c:3])-[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[C:9](=O)[c:10]1[cH:11][cH:12][cH:13][c:14]([cH:15]1)[Br:16].[CH3:17][C:18]([CH3:19])([CH3:20])[S:21]([NH2:22])=[O:23]>CCOC(C)=O.O=C(O)O[Na].C1CCOC1.CC[O-].CC[O-].CC[O-].CC[O-].CO.[Ti+4]>[CH3:17][C:18]([CH3:19])([CH3:20])[S:21](=[O:23])[N:22]=[C:9]([c:10]1[cH:11][cH:12][cH:13][c:14]([cH:15]1)[Br:16])[c:8]1[cH:7][cH:6][cH:5][cH:4][c:3]1[C:2]#[N:1]|US07629356B2_0257
9.7.58|[S&H0&-2&D0:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[S&H0&+0&D1:4]=[C&H0&+0&D3:2](-[N&H2&+0&D1:3])-[c:1]|[N:1]#[C:2][c:3]1[c:4]([cH:5][cH:6][cH:7][c:8]1[F:9])[F:10].O.[Na+].[Na+].[S-2:11]>CCN(CC)CC.c1ccncc1.Cl>[NH2:1][C:2](=[S:11])[c:3]1[c:4]([cH:5][cH:6][cH:7][c:8]1[F:9])[F:10]|US20100137313A1_0510
3.11.91|[C&H3&+0&D1:5]-I.[C:4]-[C&H1&+0&D3:3](-[S:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[S:2])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([S:6][CH3:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[CH2:14][CH:15]([CH3:16])[CH3:17].[CH3:18]I>[NH4+].[Cl-].CN(C)C=O.[H][H].[NaH]>[CH3:16][CH:15]([CH3:17])[CH2:14][c:11]1[cH:12][cH:13][c:8]([cH:9][cH:10]1)[C:5]([CH3:18])([S:6][CH3:7])[C:3](=[O:4])[O:2][CH3:1]|EP0549892A1_0028
1.8.15|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][c:3]1[n:4][c:5]([nH:6][c:7]1I)[CH3:8].[SH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>CN(C)C=O.[NaH]>[CH3:1][CH2:2][c:3]1[n:4][c:5]([nH:6][c:7]1[S:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1)[CH3:8]|US20200172546A1_1582
9.5.4|[C:5]-[C&H1&+0&D3:4](-[O:3])-[C&H1&+0&D3:2](-[c:1])-O>>[C:5]-[C&H0&+0&D3:4](-[O:3])=[C&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([O:6][CH3:7])[CH:8](O)[c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>CCOCC.CN(C)c1ccncc1.CS(=O)(=O)Cl.ClCCl>[CH3:7][O:6][C:5](=[CH:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[C:3](=[O:4])[O:2][CH3:1]|US07262303B2_0060
2.3.11|[C:5]-[N&H2&+0&D1:4].[N:3]=[C&H0&+0&D3:2](-[O:1])-O-C>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[N:3])-[O:1]|[NH:1]=[C:2]([NH2:3])[NH:4][c:5]1[n:6][c:7]([cH:8][s:9]1)[CH2:10][S:11][CH2:12][CH2:13][NH2:14].[CH3:15][O:16][C:17](=[N:18][C:19]#[N:20])OC.Cl.Cl>CCN(CC)CC.CO>[CH3:15][O:16][C:17](=[N:18][C:19]#[N:20])[NH:14][CH2:13][CH2:12][S:11][CH2:10][c:7]1[cH:8][s:9][c:5]([n:6]1)[NH:4][C:2](=[NH:1])[NH2:3]|EP2683703B1_0427
9.5.4|[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H1&+0&D3:2](-[c:1])-O>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[CH2:15][CH:16]1[CH2:17][CH2:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[CH:25]1O>O.CCOCC.CC(=O)O.O=S(=O)(O)O.O=C(O)O[Na]>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[CH2:15][C:16]1=[CH:25][c:24]2[cH:23][cH:22][cH:21][cH:20][c:19]2[CH2:18][CH2:17]1|US07932281B2_0374
9.5.4|[C&H3&+0&D1:4]-[C&H0&+0&D4:3](-[C&H3&D1:2])(-[c:1])-O>>[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C&H3&D1:2])-[c:1]|[CH3:1][C:2]([CH3:3])(O)[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1>>[CH2:3]=[C:2]([CH3:1])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1|EP3089971B1_0257
1.3.8|[N&H2&+0&D1:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[N&H1&+0&D2:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|F[c:1]1[n:2][c:3]([n:4][c:5]([c:6]1[F:7])[F:8])[F:9].[NH2:10][S:11](=[O:12])(=[O:13])[C:14]([F:15])([F:16])[F:17].[Na:18]>C1CCOC1>[O:12]=[S:11](=[O:13])([NH:10][c:1]1[n:2][c:3]([n:4][c:5]([c:6]1[F:7])[F:8])[F:9])[C:14]([F:15])([F:16])[F:17].[Na:18]|US20200002317A1_0231
1.2.9|[N&H2&+0&D1:5]-[c:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-O>>[N&H1&+0&D2:5](-[c:4])-[C&H1&+0&D3:2](-[c:3])-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[I:8])[Cl:9].O[CH:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O.CC#N.O=S(=O)(O)c1ccccc1>[Cl:9][c:5]1[cH:4][cH:3][c:2]([c:7]([cH:6]1)[I:8])[NH:1][CH:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US08815926B2_1386
3.11.91|[C&H3&+0&D1:5]-I.[C:4]-[C&H1&+0&D3:3](-[O:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[O:2])-[c:1]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[Cl:8])[O:9][CH:10]([C:11](=[O:12])[O:13][CH3:14])[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[O:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[Cl:28].[CH3:29]I>COC(=O)C(C)(Oc1ccc(cc1)Cl)c1ccc(cc1)Oc1ccc(cc1)Cl.CN(C)P(=O)(N(C)C)N(C)C.C1CCOC1.O>[CH3:14][O:13][C:11](=[O:12])[C:10]([CH3:29])([O:9][c:4]1[cH:5][cH:6][c:7]([c:2]([cH:3]1)[CH3:1])[Cl:8])[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[O:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[Cl:28]|US08729104B2_0223
3.3.4|[C&H1&+0&D1:5]#[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH:1]#[C:2][C:3]([CH3:4])([CH3:5])[O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[C:13]#[N:14].I[c:15]1[n:16][cH:17][cH:18][cH:19][n:20]1>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCN(CC)CC.I[Cu].[Cl-].[Cl-].[Pd+2]>[CH3:4][C:3]([CH3:5])([C:2]#[C:1][c:15]1[n:20][cH:19][cH:18][cH:17][n:16]1)[O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[C:13]#[N:14]|EP2855455B1_0260
2.1.18|[N&H2&+0&D1:4]-[c:3].[O&H0&D1:2]=[C&H1&+0&D2:1]-[O&-]>>[N&H1&+0&D2:4](-[c:3])-[C&H1&+0&D2:1]=[O&H0&D1:2]|[Na+].[CH3:1][CH:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH2:9])[n:10]1[cH:11][cH:12][n:13][cH:14]1.[O-][CH:15]=[O:16]>CC(=O)OC(C)=O.O=CO>[CH3:1][CH:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:9][CH:15]=[O:16])[n:10]1[cH:11][cH:12][n:13][cH:14]1|US10377759B2_0318
1.2.3|[N&H2&+0&D1:5]-[c:4].[N:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H0&+0&D2:5](-[c:4])=[C&H0&+0&D3:2](-[N:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[NH:12][C:13](=O)[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[Cl:20].[CH3:21][CH2:22][O:23][C:24](=[O:25])[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[NH2:32]>ClP(Cl)(Cl)(Cl)Cl>[CH3:21][CH2:22][O:23][C:24](=[O:25])[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[N:32]=[C:13]([NH:12][c:9]1[cH:8][cH:7][c:6]([cH:11][cH:10]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1])[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[Cl:20]|US09642363B2_0554
3.11.31|[C:5]-[C&H1&+0&D2:4]=O.[C:3]-[C&H2&+0&D2:2]-[N&+:1]>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[N&+:1]|[CH3:1][N:2]([CH3:3])[CH:4]=[C:5]([CH:6]=O)[c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[N+:13]([O-:14])=[O:15].[CH3:16][O:17][C:18](=[O:19])[CH2:20][N+:21]([O-:22])=[O:23]>CC(=O)OC(C)=O>[CH3:1][N:2]([CH3:3])[CH:4]=[C:5]([CH:6]=[C:20]([C:18](=[O:19])[O:17][CH3:16])[N+:21]([O-:22])=[O:23])[c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[N+:13]([O-:14])=[O:15]|US08680335B2_0243
1.3.8|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][c:3]1[cH:4][c:5]([c:6]([s:7]1)[NH2:8])[C:9](=[O:10])[O:11][CH2:12][CH3:13].[O-:14][N+:15](=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1F>O.CCCC[Li].C1CCOC1>[CH3:13][CH2:12][O:11][C:9](=[O:10])[c:5]1[cH:4][c:3]([s:7][c:6]1[NH:8][c:22]1[cH:21][cH:20][cH:19][cH:18][c:17]1[N+:15]([O-:14])=[O:16])[CH2:2][CH3:1]|US20100240669A1_1540
1.7.11|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)F.[O:9]=[C:10]([OH:11])[CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[OH:19]>[Na+].CC(=O)N(C)C.[O-]C(=O)O.O=C(O[K])O[K]>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:19][c:16]1[cH:17][cH:18][c:13]([cH:14][cH:15]1)[CH2:12][C:10](=[O:9])[OH:11]|EP0295233A2_0087
9.5.4|[C:5]-[C&H1&+0&D3:4](-[c:3])-[C&H1&+0&D3:2](-[c:1])-O>>[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[O:7][CH:8]([CH:9]([CH:10]([c:11]2[cH:12]1)O)[c:13]1[n:14][cH:15][cH:16][n:17]1[CH3:18])[CH2:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>O=P12OP3(OP(O2)(OP(O1)(O3)=O)=O)=O.c1ccccc1>[CH3:18][n:17]1[cH:16][cH:15][n:14][c:13]1[C:9]1=[CH:10][c:11]2[cH:12][c:3]([cH:4][cH:5][c:6]2[O:7][CH:8]1[CH2:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[O:2][CH3:1]|EP2361910A1_0246
1.3.9|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([n:5]([n:6]1)[CH3:7])[NH2:8].[O:9]=[C:10]([OH:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1I>O.O=C(O[K])O[K].[Cu]>[CH3:1][c:2]1[cH:3][c:4]([n:5]([n:6]1)[CH3:7])[NH:8][c:17]1[cH:16][cH:15][cH:14][cH:13][c:12]1[C:10](=[O:9])[OH:11]|US20110082173A1_0281
1.2.6|[N&H2&+0&D1:5]-[N:4].[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H0&+0&D2:5](-[N:4])=[C&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][N:2]([NH2:3])[C:4](=[S:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([cH:11][c:12]1[C:13](=O)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[Cl:20]>CCCO>[CH3:1][N:2]1[N:3]=[C:13]([c:12]2[cH:11][c:10]([cH:9][cH:8][c:7]2[NH:6][C:4]1=[S:5])[Cl:20])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|EP3640253A1_0358
8.4.2|[O&H1&+0&D1:5]-O.[O:4]-[P&H0&+0&D3:3](-[O:2])-[O:1]>>[O&H0&+0&D1:5]=[P&H0&+0&D4:3](-[O:4])(-[O:2])-[O:1]|[CH3:1][C:2](=[O:3])[O:4][C@H:5]1[C@@H:6]([C@@H:7]([CH:8]([O:9][C@@H:10]1[O:11][P:12]([O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[O:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[CH3:29])[O:30][C:31]([CH3:32])=[O:33])[O:34][C:35]([CH3:36])=[O:37].[OH:38]O>C1CCOC1>[CH3:32][C:31](=[O:33])[O:30][C@@H:7]1[CH:8]([O:9][C@@H:10]([C@H:5]([C@@H:6]1[O:34][C:35]([CH3:36])=[O:37])[O:4][C:2]([CH3:1])=[O:3])[O:11][P:12](=[O:38])([O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[O:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[CH3:29]|EP1083175A2_0178
9.7.241|[C:4]-[C&H0&+0&D3:3](=[O&H0&D1:2])-C.[O&H0&-&D1:1]-Br>>[C:4]-[C&H0&+0&D3:3](-[O&H1&+0&D1:1])=[O&H0&D1:2]|C[C:1](=[O:2])[C:3]12[CH2:4][CH:5]3[CH2:6][CH:7]1[CH2:8][C:9]([CH2:10]3)([CH2:11]2)[CH2:12][O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[O-:21]Br>C1COCCO1.CC(=O)O.BrBr.O.[Na+].[OH-]>[O:2]=[C:1]([OH:21])[C:3]12[CH2:4][CH:5]3[CH2:6][CH:7]1[CH2:8][C:9]([CH2:10]3)([CH2:11]2)[CH2:12][O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20100160302A1_0288
1.8.14|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[SH:8].[F:9][c:10]1[cH:11][cH:12][cH:13][c:14]([n:15]1)F>COCCOC.O[K]>[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8][c:14]1[cH:13][cH:12][cH:11][c:10]([n:15]1)[F:9]|EP3368544B1_0606
10.1.8|[Br&H1&+0&D0:4].[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[C:1]|[CH2:1]=[CH:2][CH2:3][CH2:4][Si:5]([CH3:6])([CH3:7])[CH3:8].[BrH:9]>C=CCCBr.C[Si](C)(C)Cl>[CH3:6][Si:5]([CH3:7])([CH3:8])[CH2:4][CH2:3][CH2:2][CH2:1][Br:9]|US20090137773A1_0343
1.7.17|[O&H2&+0&D0:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[O&H1&+0&D1:4]-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[OH2:1].[CH2:2]=[C:3]([CH3:4])[C:5](=[O:6])[O:7][CH2:8][CH:9]1[CH2:10][O:11]1>>[CH2:2]=[C:3]([CH3:4])[C:5](=[O:6])[O:7][CH2:8][CH:9]([OH:11])[CH2:10][OH:1]|EP2894151B1_0230
1.8.13|[S&H1&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[OH:1][c:2]1[n:3][n:4]([c:5]([n:6]1)Cl)-[c:7]1[cH:8][cH:9][cH:10][cH:11][n:12]1.[SH:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>CO.[Na]>[OH:1][c:2]1[n:3][n:4]([c:5]([n:6]1)[S:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)-[c:7]1[cH:8][cH:9][cH:10][cH:11][n:12]1|US20130303533A1_1070
1.7.11|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[o:1])-Br>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][C:2]1([O:3][CH2:4][c:5]2[cH:6][c:7]([c:8]([cH:9][c:10]21)[OH:11])[CH3:12])[CH3:13].[CH3:14][O:15][C:16](=[O:17])[c:18]1[cH:19][cH:20][c:21]([o:22]1)Br>CN(C)C=O.O=C(O[Cs])O[Cs]>[CH3:14][O:15][C:16](=[O:17])[c:18]1[cH:19][cH:20][c:21]([o:22]1)[O:11][c:8]1[cH:9][c:10]2[c:5]([cH:6][c:7]1[CH3:12])[CH2:4][O:3][C:2]2([CH3:1])[CH3:13]|US20090291915A1_0115
9.7.157|[C:4]-[C&H2&+0&D2:3]-Cl.[N&H0&D1:2]#[C&H0&+0&D2:1]-[#19]>>[C:4]-[C&H2&+0&D2:3]-[C&H0&+0&D2:1]#[N&H0&D1:2]|[N:1]#[C:2][K].[OH:3][CH:4]([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[CH2:17][CH:18]([OH:19])[CH2:20]Cl>O.CCO>[N:1]#[C:2][CH2:20][CH:18]([OH:19])[CH2:17][c:15]1[cH:14][cH:13][cH:12][c:11]([cH:16]1)[CH:4]([OH:3])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|EP2397141A1_0080
2.6.9|[C:5]-[C@&H1&+0&D3:4](-[c:3])-O.[C:2]-[O&H1&+0&D1:1]>>[C:5]-[C@@&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[c:3]|[CH3:1][CH:2]([CH3:3])[C@@H:4]([NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1[Cl:12])[C:13]([F:14])([F:15])[F:16])[C:17](=[O:18])[OH:19].[N:20]#[C:21][C@@H:22](O)[c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[O:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1ccncc1.ClC(Cl)Cl.ClCCl>[CH3:1][CH:2]([CH3:3])[C@@H:4]([NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1[Cl:12])[C:13]([F:14])([F:15])[F:16])[C:17](=[O:18])[O:19][C@H:22]([C:21]#[N:20])[c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[O:29][c:30]1[cH:35][cH:34][cH:33][cH:32][cH:31]1|US20200361945A1_0608
1.8.12|[S&H1&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][c:2]1[n:3][n:4]([n:5][c:6]1[SH:7])-[c:8]1[c:9]([cH:10][c:11]([cH:12][c:13]1[Cl:14])[C:15]([F:16])([F:17])[F:18])[Cl:19].[CH3:20][Si:21]([CH3:22])([CH3:23])[CH2:24][CH2:25][O:26][CH2:27][n:28]1[c:29]([c:30]([n:31][c:32]1Br)[C:33]#[N:34])[C:35]#[N:36]>C1CCOC1.O.[NaH]>[CH3:20][Si:21]([CH3:22])([CH3:23])[CH2:24][CH2:25][O:26][CH2:27][n:28]1[c:29]([c:30]([n:31][c:32]1[S:7][c:6]1[n:5][n:4]([n:3][c:2]1[CH3:1])-[c:8]1[c:9]([cH:10][c:11]([cH:12][c:13]1[Cl:14])[C:15]([F:16])([F:17])[F:18])[Cl:19])[C:33]#[N:34])[C:35]#[N:36]|US20140275528A1_0677
9.7.106|[N&+:5]=[N&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[N&+:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][nH:6][c:7]1[CH:8]=[C:9]1[C:10]([NH:11][c:12]2[cH:13][cH:14][c:15]([c:16]([c:17]12)F)[N+:18]([O-:19])=[O:20])=[O:21].[N-:22]=[N+:23]=[N-:24]>CC(C)N(CC)C(C)C.C1CCOC1.CCO>[CH3:1][O:2][c:3]1[cH:4][cH:5][nH:6][c:7]1[CH:8]=[C:9]1[C:10]([NH:11][c:12]2[cH:13][cH:14][c:15]([c:16]([c:17]12)[N:24]=[N+:23]=[N-:22])[N+:18]([O-:19])=[O:20])=[O:21]|EP3423446B1_0149
3.3.2|[C&H1&+0&D1:5]#[C:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[O:9]=[CH:10][c:11]1[cH:12][cH:13][c:14]([s:15]1)Br>CCN(CC)CC>[CH3:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]#[C:1][c:14]1[cH:13][cH:12][c:11]([s:15]1)[CH:10]=[O:9]|US20200392097A1_0121
3.3.2|[C&H1&+0&D1:5]#[C:4].[c:3]:[c&H0&+0&D3:2](:[o:1])-Br>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[O:9]=[CH:10][c:11]1[cH:12][cH:13][c:14]([o:15]1)Br>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCCCCC.CCCC[Li].C1CCOC1.Cl[Zn]Cl.Cl>[CH3:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]#[C:1][c:14]1[cH:13][cH:12][c:11]([o:15]1)[CH:10]=[O:9]|US20200392096A1_0268
1.3.6|[N&H2&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[F:14])[NH2:15].Br[c:16]1[n:17][cH:18][cH:19][s:20]1>ClCCl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[F:14])[NH:15][c:16]1[n:17][cH:18][cH:19][s:20]1|US20100113520A1_0284
1.7.9|[O&H1&+0&D1:5]-[c:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-Br>>[O&H0&+0&D2:5](-[c:4])-[C&H1&+0&D3:2](-[c:3])-[c:1]|[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][CH2:6][n:7]1[cH:8][c:9]([c:10]2[c:11]1[cH:12][cH:13][cH:14][cH:15]2)[C:16](=[O:17])[c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[OH:24].[CH3:25][CH:26]([CH3:27])[CH2:28][c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[CH:35](Br)[c:36]1[cH:37][cH:38][c:39]([cH:40][cH:41]1)[CH2:42][CH:43]([CH3:44])[CH3:45]>CCOC(C)=O.CN(C)C=O.C1CCOC1.Cl.[NaH]>[CH3:25][CH:26]([CH3:27])[CH2:28][c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[CH:35]([O:24][c:22]1[cH:21][cH:20][cH:19][c:18]([cH:23]1)[C:16](=[O:17])[c:9]1[cH:8][n:7]([c:11]2[c:10]1[cH:15][cH:14][cH:13][cH:12]2)[CH2:6][CH2:5][CH2:4][C:2](=[O:1])[OH:3])[c:36]1[cH:37][cH:38][c:39]([cH:40][cH:41]1)[CH2:42][CH:43]([CH3:44])[CH3:45]|US20200360521A1_0325
3.2.1|[C&H2&+0&D1:5]=[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H1&+0&D2:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][c:7]([n:8]1)Br)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[C:15]([F:16])([F:17])[F:18].[CH2:19]=[CH:20][C:21](=[O:22])[O:23][CH2:24][CH3:25]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.N#Cc1ccc(cc1)C(F)(F)F.CC(=O)O[Pd]OC(C)=O.Brc1cccc(n1)Br.CCN(CC)CC.CCOCC.CCCC[Li]>[CH3:25][CH2:24][O:23][C:21](=[O:22])/[CH:20]=[CH:19]/[c:7]1[cH:6][cH:5][cH:4][c:3]([n:8]1)[C:2](=[O:1])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[C:15]([F:16])([F:17])[F:18]|US20200360387A1_0189
1.8.13|[S&H1&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([s:8][c:9]1-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)Cl.[SH:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O.CN(C)C=O.[O-]C([O-])=O.[K+].[K+]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([s:8][c:9]1-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[S:16][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|US20200016140A1_0157
1.3.7|[N&H2&+0&D1:5]-[O:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[O:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][NH2:3].[NH2:4][c:5]1[n:6][c:7]([n:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21)Cl>>[CH3:1][O:2][NH:3][c:7]1[n:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[c:5]([n:6]1)[NH2:4]|US20190161473A1_0215
3.3.2|[C&H1&+0&D1:5]#[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH:1]#[C:2][C@H:3]1[CH2:4][CH2:5][C@@H:6]([CH2:7][CH2:8]1)[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[CH3:14][CH2:15][CH2:16][c:17]1[cH:18][cH:19][c:20]([n:21][n:22]1)Br>CCN(CC)CC.I[Cu]>[CH3:14][CH2:15][CH2:16][c:17]1[cH:18][cH:19][c:20]([n:21][n:22]1)[C:1]#[C:2][C@@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:5][CH2:4]1)[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]|EP3555085B1_0134
1.2.9|[C:5]-[C@@&H1&+0&D3:4](-[C:3])-O.[C:2]-[N&H2&+0&D1:1]>>[C:5]-[C@&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:1]-[C:2]|[NH2:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[O:9]=[C:10]1[CH2:11][C@@H:12]([CH2:13][O:14]1)O>CCN(CC)CC.O=C(O[Cs])O[Cs].CN(C)C=O.CS(=O)(=O)Cl.ClCCl>[O:9]=[C:10]1[CH2:11][C@H:12]([CH2:13][O:14]1)[NH:1][CH2:2][c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1|US09540391B2_0668
1.3.7|[N&H2&+0&D1:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[n:4][s:5][n:6][c:7]1Cl.[NH2:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[S:15]([NH2:16])(=[O:17])=[O:18]>O.Cl.CS(C)=O.O=C(O[K])O[K]>[CH3:1][O:2][c:3]1[n:4][s:5][n:6][c:7]1[NH:16][S:15](=[O:17])(=[O:18])[c:12]1[cH:13][cH:14][c:9]([cH:10][cH:11]1)[NH2:8]|US08269002B2_0206
3.11.86|[C&H3&+0&D1:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H2&+0&D2:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[F:10].Cl[c:11]1[cH:12][cH:13][c:14]([cH:15][n:16]1)[Cl:17]>C1CCOC1.[NaH]>[O:3]=[C:2]([CH2:1][c:11]1[cH:12][cH:13][c:14]([cH:15][n:16]1)[Cl:17])[c:4]1[cH:9][cH:8][c:7]([cH:6][cH:5]1)[F:10]|EP1694649B1_0069
1.3.7|[N&H2&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[Br:8].[O-:9][N+:10](=[O:11])[c:12]1[s:13][c:14]([n:15][c:16]1[Cl:17])Cl>O.O.CN(C)C=O>[O-:9][N+:10](=[O:11])[c:12]1[s:13][c:14]([n:15][c:16]1[Cl:17])[NH:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[Br:8]|US07115597B2_0446
1.3.7|[N&H2&+0&D1:5]-[S:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[S:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][n:2]1[c:3]2[c:4]([n:5][c:6]([n:7][c:8]2[n:9][c:10]1Cl)[Cl:11])[Cl:12].[NH2:13][S:14](=[O:15])(=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O.O.Cl.CN(C)C=O.[Na]>[CH3:1][n:2]1[c:3]2[c:4]([n:5][c:6]([n:7][c:8]2[n:9][c:10]1[NH:13][S:14](=[O:15])(=[O:16])[c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1)[Cl:11])[Cl:12]|EP3543232A1_0194
2.8.5|[C:5]-[C@&H1&+0&D3:4](-[C:3])-O.[C:2]-[S&H1&+0&D1:1]>>[C:5]-[C@@&H1&+0&D3:4](-[C:3])-[S&H0&+0&D2:1]-[C:2]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10][O:11][C:12](=[O:13])[N:14]1[CH2:15][C@@H:16]([CH2:17][C@H:18]1[CH2:19][S:20][CH:21]([F:22])[F:23])O.[O:24]=[C:25]([SH:26])[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)N=NC(=O)OCC.C1CCOC1>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10][O:11][C:12](=[O:13])[N:14]1[CH2:15][C@H:16]([CH2:17][C@H:18]1[CH2:19][S:20][CH:21]([F:22])[F:23])[S:26][C:25](=[O:24])[c:27]1[cH:32][cH:31][cH:30][cH:29][cH:28]1|US20100056565A1_0650
1.2.14|[N&H3&+0&D0:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[N&H2&+0&D1:4]-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[NH3:1].[cH:2]1[s:3][n:4][n:5][c:6]1-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[O:13][CH2:14][CH:15]1[CH2:16][O:17]1>CCO>[NH2:1][CH2:16][CH:15]([OH:17])[CH2:14][O:13][c:10]1[cH:9][cH:8][c:7]([cH:12][cH:11]1)-[c:6]1[cH:2][s:3][n:4][n:5]1|US20200316065A1_1331
1.3.7|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH2:9].[CH3:10][c:11]1[cH:12][c:13]([n:14][c:15]([n:16]1)[S:17][CH2:18][C:19]#[N:20])Cl>CCO.O=C(O[Na])O[Na]>[CH3:1][O:2][c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[NH:9][c:13]1[cH:12][c:11]([n:16][c:15]([n:14]1)[S:17][CH2:18][C:19]#[N:20])[CH3:10]|US07576090B2_0274
1.3.7|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH2:8])[C:9](=[O:10])[OH:11].Cl[c:12]1[cH:13][cH:14][n:15][c:16]2[cH:17][c:18]([cH:19][cH:20][c:21]12)[Cl:22]>Cl>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH:8][c:12]1[cH:13][cH:14][n:15][c:16]2[cH:17][c:18]([cH:19][cH:20][c:21]21)[Cl:22])[C:9](=[O:10])[OH:11]|US20110269758A1_0419
1.6.4|[#14:5]-[C&H2&+0&D2:4]-Cl.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[#14:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]([CH3:3])[NH:4][CH2:5][CH2:6][NH:7][C:8](=[O:9])[CH2:10][N:11]1[CH2:12][CH2:13][CH2:14][C:15]1=[O:16].[CH3:17][Si:18]([CH3:19])([CH3:20])[CH2:21]Cl>CCN(CC)CC>[CH3:1][CH:2]([CH3:3])[N:4]([CH2:5][CH2:6][NH:7][C:8](=[O:9])[CH2:10][N:11]1[CH2:12][CH2:13][CH2:14][C:15]1=[O:16])[CH2:21][Si:18]([CH3:17])([CH3:19])[CH3:20]|US20100022475A1_0134
3.3.3|[C&H1&+0&D1:5]#[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[S:7][C:8]([CH2:9][C:10]([c:11]2[cH:12]1)([CH3:13])[CH3:14])([CH3:15])[CH3:16].[CH3:17][CH2:18][O:19][C:20](=[O:21])[c:22]1[cH:23][n:24][c:25]([cH:26][cH:27]1)Cl>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCN(CC)CC.Cl[Pd]Cl.I[Cu]>[CH3:17][CH2:18][O:19][C:20](=[O:21])[c:22]1[cH:23][n:24][c:25]([cH:26][cH:27]1)[C:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[S:7][C:8]([CH2:9][C:10]([c:11]2[cH:12]1)([CH3:13])[CH3:14])([CH3:15])[CH3:16]|EP3233829B1_0225
1.7.8|[O&H1&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]([CH3:10])[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[OH:17].Br[c:18]1[n:19][cH:20][cH:21][cH:22][n:23]1>CCOC(C)=O.O=C(O[K])O[K].c1ccncc1.ClCCl.[I-].[I-].[Cu+2]>[CH3:10][C@H:9]([NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[O:17][c:18]1[n:23][cH:22][cH:21][cH:20][n:19]1|US09359359B2_1472
1.3.7|[N&H2&+0&D1:5]-[c:4].[N:3]-[C&H0&+0&D3:2](=[N:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](-[N:3])=[N:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.Cl[C:8]1=[N:9][CH:10]2[CH2:11][CH2:12][CH2:13][c:14]3[cH:15][cH:16][cH:17][c:18]([NH:19]1)[c:20]32>O>[cH:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[NH:1][C:8]1=[N:9][CH:10]2[CH2:11][CH2:12][CH2:13][c:14]3[cH:15][cH:16][cH:17][c:18]([NH:19]1)[c:20]32|US06417186B1
1.7.8|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[OH:9].[CH3:10][c:11]1[cH:12][cH:13][c:14]([c:15]([cH:16]1)[CH3:17])Br>CN(C)C(=O)N(C)C.CN1CCCC1=O.O.[O-2].[Cu+].[Cu+]>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[O:9][c:14]1[cH:13][cH:12][c:11]([cH:16][c:15]1[CH3:17])[CH3:10]|US08916551B2_0916
9.7.155|[C:4]-[C&H2&+0&D2:3]-Br.[N&H0&D1:2]#[C&H0&+0&D2:1]-[#11]>>[C:4]-[C&H2&+0&D2:3]-[C&H0&+0&D2:1]#[N&H0&D1:2]|[CH3:1][C@H:2]([CH2:3]Br)[CH2:4][O:5][C:6]([CH3:7])([CH3:8])[CH3:9].[N:10]#[C:11][Na].BrOBr>O>[CH3:1][C@H:2]([CH2:3][C:11]#[N:10])[CH2:4][O:5][C:6]([CH3:7])([CH3:8])[CH3:9]|EP3307729B1_0367
1.3.6|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.Br[c:16]1[cH:17][cH:18][cH:19][cH:20][n:21]1>>[cH:13]1[cH:14][cH:15][c:10]([cH:11][cH:12]1)[CH2:9][O:8][c:5]1[cH:6][cH:7][c:2]([cH:3][cH:4]1)[NH:1][c:16]1[cH:17][cH:18][cH:19][cH:20][n:21]1|US09598405B2_0427
10.1.4|[I&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[o:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[o:1]|[O:1]=[c:2]1[nH:3][cH:4][n:5][c:6]2[o:7][cH:8][c:9]([c:10]21)-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.O=C1CCC(N1[I:17])=O>ClC(Cl)(Cl)Cl.CC#N>[O:1]=[c:2]1[nH:3][cH:4][n:5][c:6]2[o:7][c:8]([c:9]([c:10]12)-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[I:17]|EP2274305B1_0108
3.11.86|[C&H3&+0&D1:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H2&+0&D2:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][C:2](=[O:3])[N:4]1[CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[CH2:10][c:11]1[cH:12][cH:13][c:14]2[O:15][CH2:16][O:17][c:18]2[cH:19]1.Cl[c:20]1[n:21][c:22]([n:23][c:24]([n:25]1)[N:26]1[CH2:27][CH2:28][O:29][CH2:30][CH2:31]1)[Cl:32]>C[Si](C)(C)[N-][Si](C)(C)C.[Li+]>[O:3]=[C:2]([CH2:1][c:20]1[n:21][c:22]([n:23][c:24]([n:25]1)[N:26]1[CH2:27][CH2:28][O:29][CH2:30][CH2:31]1)[Cl:32])[N:4]1[CH2:9][CH2:8][N:7]([CH2:6][CH2:5]1)[CH2:10][c:11]1[cH:12][cH:13][c:14]2[O:15][CH2:16][O:17][c:18]2[cH:19]1|US09133168B2_2323
1.3.7|[N&H2&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[o:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[o:1]|[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[F:8])[C:9]([F:10])([F:11])[F:12].Cl[c:13]1[n:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[o:21]1>C1CCOC1>[F:10][C:9]([F:11])([F:12])[c:4]1[cH:5][cH:6][c:7]([c:2]([cH:3]1)[NH:1][c:13]1[n:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[o:21]1)[F:8]|US05000775A
1.8.12|[C&H3&D1:4]-[S&H0&+0&D2:3]-[#11].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[CH2:11]Br.[CH3:12][S:13][Na]>C1CCOC1>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[CH2:11][S:13][CH3:12]|US10815225B2_1062
10.1.4|[I&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[C:6](=[O:7])[NH:8][C@H:9]1[CH2:10][C@@H:11]2[c:12]3[cH:13][cH:14][cH:15][c:16]4[nH:17][cH:18][c:19]([CH2:20][C@H:21]2[N:22]([CH2:23]1)[CH3:24])[c:25]43.O=C1CCC(N1[I:26])=O>C1COCCO1.[O-]C(=O)O>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[C:6](=[O:7])[NH:8][C@H:9]1[CH2:10][C@@H:11]2[c:12]3[cH:13][cH:14][cH:15][c:16]4[nH:17][c:18]([c:19]([CH2:20][C@H:21]2[N:22]([CH2:23]1)[CH3:24])[c:25]43)[I:26]|EP3400221B1_0434
1.3.7|[N&H2&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH2:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH2:9].Cl[c:10]1[n:11][c:12]([n:13][c:14]([n:15]1)[Cl:16])[Cl:17]>CC(C)N(CC)C(C)C.CC(C)=O.O>[CH2:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:9][c:10]1[n:11][c:12]([n:13][c:14]([n:15]1)[Cl:16])[Cl:17]|US07115740B2_0380
1.3.7|[N&H2&+0&D1:5]-[N:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&H1&+0&D2:5](-[N:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH2:1][NH:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[OH:11].Cl[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>O=C(O)c1ccccc1.O=S(Cl)Cl.c1ccncc1>[O:4]=[C:3]([NH:2][NH:1][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[OH:11]|EP2576546B1_0314
1.8.12|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([n:7]1)Br.[SH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>CN(C)P(=O)(N(C)C)N(C)C.C1CCOC1.O>[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([n:7]1)[S:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US20200002330A1_0312
1.7.9|[C:5]-[C@@&H1&+0&D3:4](-[O:3])-Cl.[C:2]-[O&H1&+0&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[O:3]|[CH3:1][C:2](=[O:3])[O:4][C@H:5]1[C@H:6]([O:7][C@H:8]([C@@H:9]([C@H:10]1[OH:11])[O:12][C:13]([CH3:14])=[O:15])[O:16][C@@H:17]1[C@H:18]([O:19][C@H:20]([C@@H:21]([C@H:22]1[O:23][C:24]([CH3:25])=[O:26])[NH:27][C:28]([CH3:29])=[O:30])[O:31][CH2:32][CH2:33][CH2:34][NH:35][C:36](=[O:37])[C:38]([F:39])([F:40])[F:41])[CH2:42][O:43][CH2:44][c:45]1[cH:46][cH:47][cH:48][cH:49][cH:50]1)[CH2:51][O:52][CH2:53][c:54]1[cH:55][cH:56][cH:57][cH:58][cH:59]1.[CH3:60][C:61](=[O:62])[O:63][CH:64]1[C@H:65]([C@H:66]([O:67][C@H:68]([C@@H:69]1[N:70]=[N+:71]=[N-:72])Cl)[CH2:73][O:74][C:75]([CH3:76])=[O:77])[O:78][C:79]([CH3:80])=[O:81]>>[CH3:76][C:75](=[O:77])[O:74][CH2:73][C@H:66]1[O:67][CH:68]([C@@H:69]([CH:64]([C@H:65]1[O:78][C:79]([CH3:80])=[O:81])[O:63][C:61]([CH3:60])=[O:62])[N:70]=[N+:71]=[N-:72])[O:11][C@H:10]1[C@H:5]([C@H:6]([O:7][C@H:8]([C@@H:9]1[O:12][C:13]([CH3:14])=[O:15])[O:16][C@@H:17]1[C@H:18]([O:19][C@H:20]([C@@H:21]([C@H:22]1[O:23][C:24]([CH3:25])=[O:26])[NH:27][C:28]([CH3:29])=[O:30])[O:31][CH2:32][CH2:33][CH2:34][NH:35][C:36](=[O:37])[C:38]([F:39])([F:40])[F:41])[CH2:42][O:43][CH2:44][c:45]1[cH:46][cH:47][cH:48][cH:49][cH:50]1)[CH2:51][O:52][CH2:53][c:54]1[cH:55][cH:56][cH:57][cH:58][cH:59]1)[O:4][C:2]([CH3:1])=[O:3]|US05157116A
1.3.7|[N&H2&+0&D1:5]-[N:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[N:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[O:9][CH3:10])-[c:11]1[cH:12][c:13]([n:14]([c:15]([n:16]1)Cl)[CH3:17])=[N:18][c:19]1[c:20]([cH:21][c:22]([cH:23][c:24]1[CH3:25])[CH3:26])[CH3:27].[NH2:28][NH:29][CH:30]=[O:31]>ClC(Cl)Cl>[CH3:26][c:22]1[cH:21][c:20]([c:19]([c:24]([cH:23]1)[CH3:25])[N:18]=[c:13]1[cH:12][c:11]([n:16][c:15]([n:14]1[CH3:17])[NH:28][NH:29][CH:30]=[O:31])-[c:6]1[cH:5][cH:4][c:3]([c:8]([cH:7]1)[O:9][CH3:10])[O:2][CH3:1])[CH3:27]|US09012462B2_0877
9.7.155|[N&H0&D1:4]#[C&H0&+0&D2:3]-[#11].[c:2]-[C&H2&+0&D2:1]-Br>>[N&H0&D1:4]#[C&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[N:1]#[C:2][Na].Br[CH2:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[Br:10]>O.CCO>[N:1]#[C:2][CH2:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[Br:10]|US20200383988A1_1979
3.2.2|[C&H2&+0&D1:5]=[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H1&+0&D2:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][n:9][c:10]1Cl.[CH2:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CC(=O)O[Pd]OC(C)=O.CN(C)C=O.CC([O-])=O.[Na+]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][n:9][c:10]1[CH:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US20150299188A1_1065
9.7.73|[C:5]-[C&H1&+0&D3:4](-[C:3])-O.[N&+:2]=[N&H0&-&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H0&+0&D2:1]=[N&+:2]|[Na+].[N-:1]=[N+:2]=[N-:3].[N:4]#[C:5][CH2:6][C:7]1([CH2:8][CH2:9][CH:10]([CH2:11][CH2:12]1)O)[n:13]1[cH:14][c:15]([c:16]([n:17]1)[NH:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25])[C:26]([NH2:27])=[O:28]>O.[Na+].CN(C)C=O.CS(=O)(=O)Cl.[O-]C(=O)O.ClCCl>[N-:3]=[N+:2]=[N:1][CH:10]1[CH2:11][CH2:12][C:7]([CH2:8][CH2:9]1)([CH2:6][C:5]#[N:4])[n:13]1[cH:14][c:15]([c:16]([n:17]1)[NH:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25])[C:26]([NH2:27])=[O:28]|US20100297079A1_0378
1.7.8|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[F:8].Br[c:9]1[cH:10][cH:11][cH:12][s:13]1>O=C(O[K])O[K].c1ccncc1.[Cu]>[F:8][c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[O:1][c:9]1[cH:10][cH:11][cH:12][s:13]1|US20160221994A1_0940
3.3.3|[C&H1&+0&D1:5]#[C:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|Cl[c:1]1[n:2][c:3]([cH:4][s:5]1)[Cl:6].[CH:7]#[C:8][C:9]([CH3:10])([CH3:11])[NH2:12]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCN(CC)CC.I[Cu].[Cl-].[Cl-].[Pd+2]>[CH3:10][C:9]([CH3:11])([NH2:12])[C:8]#[C:7][c:1]1[n:2][c:3]([cH:4][s:5]1)[Cl:6]|US20200347089A1_0436
1.7.11|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[OH:11].[NH2:12][S:13](=[O:14])(=[O:15])[c:16]1[cH:17][c:18]([cH:19][c:20]([c:21]1Cl)[N+:22]([O-:23])=[O:24])[C:25](=[O:26])[OH:27]>Cl.O=C(O)O[Na]>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][c:21]1[c:20]([cH:19][c:18]([cH:17][c:16]1[S:13]([NH2:12])(=[O:14])=[O:15])[C:25](=[O:26])[OH:27])[N+:22]([O-:23])=[O:24]|US06869962B2_00331
10.1.4|[I&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[C:8](=[N:9][CH2:10][c:11]1[n:12][n:13][cH:14][n:15]1-2)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.O=C1CCC(N1[I:22])=O>c1ccccc1.O=C(O)O[Na].Cl[Na].O>[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[C:8](=[N:9][CH2:10][c:11]1[n:12][n:13][c:14]([n:15]1-2)[I:22])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20190276429A1_0032
1.6.4|[N&H2&+0&D1:5]-[c:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[C&H1&+0&D3:2](-[c:3])-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[C:8](=[O:9])[c:10]1[cH:11][n:12]([c:13]2[c:14]1[cH:15][cH:16][cH:17][cH:18]2)[CH2:19][CH2:20][CH2:21][C:22](=[O:23])[OH:24].[CH3:25][CH:26]([CH3:27])[CH2:28][c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[CH:35](Cl)[c:36]1[cH:37][cH:38][c:39]([cH:40][cH:41]1)[CH2:42][CH:43]([CH3:44])[CH3:45]>CC(C)N(CC)C(C)C.ClCCl.Cl>[CH3:25][CH:26]([CH3:27])[CH2:28][c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[CH:35]([NH:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[C:8](=[O:9])[c:10]1[cH:11][n:12]([c:13]2[c:14]1[cH:15][cH:16][cH:17][cH:18]2)[CH2:19][CH2:20][CH2:21][C:22](=[O:23])[OH:24])[c:36]1[cH:37][cH:38][c:39]([cH:40][cH:41]1)[CH2:42][CH:43]([CH3:44])[CH3:45]|US04933355A
1.7.11|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[OH:10].[O:11]=[C:12]([OH:13])[c:14]1[cH:15][cH:16][cH:17][n:18][c:19]1Cl>CO.[Na]>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][c:19]1[n:18][cH:17][cH:16][cH:15][c:14]1[C:12](=[O:11])[OH:13]|US08551999B2_0415
3.2.2|[C&H2&+0&D1:5]=[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H1&+0&D2:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)Cl.[CH2:8]=[CH:9][C:10](=[O:11])[O:12][CH2:13][CH3:14]>CCCCN(CCCC)CCCC.CC(=O)O[Pd]OC(C)=O.Cc1ccc(cc1)C>[CH3:14][CH2:13][O:12][C:10](=[O:11])[CH:9]=[CH:8][c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH3:1]|EP3604281A1_0198
3.11.16|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)I.[CH3:10][C:11]([CH3:12])([CH3:13])[O:14][C:15](=[O:16])[CH2:17]Br>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CN(C)P(=O)(N(C)C)N(C)C.C[Si](C)(C)Cl.C1CCOC1.O.[Zn]>[CH3:10][C:11]([CH3:12])([CH3:13])[O:14][C:15](=[O:16])[CH2:17][c:7]1[cH:6][cH:5][c:4]([cH:9][cH:8]1)[C:2](=[O:1])[OH:3]|EP2162454B1_0441
3.11.16|[C:5]-[C&H2&+0&D2:4]-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C@@H:6]1[CH2:7][CH2:8][C@H:9]([CH2:10][CH2:11]1)[CH2:12][CH2:13]I.[F:14][C:15]([F:16])([F:17])[O:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)Br>[CH]1[CH][CH][C]([CH]1)P(c1ccccc1)c1ccccc1.[CH]1[CH][CH][C]([CH]1)P(c1ccccc1)c1ccccc1.Cc1ccccc1.C1CCOC1.Cl[Pd]Cl.Br[Zn]Br.[NH4+].[Cl-].[Li].[Fe]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C@@H:6]1[CH2:7][CH2:8][C@H:9]([CH2:10][CH2:11]1)[CH2:12][CH2:13][c:22]1[cH:21][cH:20][c:19]([cH:24][cH:23]1)[O:18][C:15]([F:14])([F:16])[F:17]|US08357711B2_0975
1.3.6|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]1Br.[NH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[C:19](=[O:20])[OH:21]>[O-][N+](=O)c1ccccc1.O=C(O[K])O[K].[Cu]>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[c:11]1[NH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[C:19](=[O:20])[OH:21]|US07345050B2_0137
1.3.6|[N&H2&+0&D1:5]-[N:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[N&H1&+0&D2:5](-[N:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|Cl.[NH2:1][N:2]1[CH2:3][CH2:4][CH2:5][C:6]1=[O:7].Br[c:8]1[cH:9][cH:10][n:11][cH:12][cH:13]1>Oc1ccccc1>[O:7]=[C:6]1[CH2:5][CH2:4][CH2:3][N:2]1[NH:1][c:8]1[cH:13][cH:12][n:11][cH:10][cH:9]1|US07282501B2_0930
3.11.16|[C:5]-[C&H2&+0&D2:4]-I.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][P:3](=[O:4])([CH2:5][c:6]1[cH:7][c:8]2[cH:9][c:10]([c:11]([cH:12][c:13]2[n:14][c:15]1Br)[Cl:16])[Cl:17])[O:18][CH3:19].[CH3:20][C:21]([CH3:22])([CH3:23])[O:24][C:25](=[O:26])[NH:27][C@H:28]([CH2:29]I)[C:30](=[O:31])[O:32][CH3:33]>Cc1ccccc1P(c1ccccc1C)c1ccccc1C.CC(=O)N(C)C.c1ccccc1.O.[Cl-].[Cl-].[Cu].[Zn].[Pd+2]>[CH3:33][O:32][C:30](=[O:31])[C@@H:28]([CH2:29][c:15]1[n:14][c:13]2[cH:12][c:11]([c:10]([cH:9][c:8]2[cH:7][c:6]1[CH2:5][P:3](=[O:4])([O:18][CH3:19])[O:2][CH3:1])[Cl:17])[Cl:16])[NH:27][C:25](=[O:26])[O:24][C:21]([CH3:20])([CH3:22])[CH3:23]|US20200108075A1_1604
9.7.157|[N&H0&D1:4]#[C&H0&+0&D2:3]-[#11].[c:2]-[C&H2&+0&D2:1]-Cl>>[N&H0&D1:4]#[C&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[N:1]#[C:2][Na].Cl[CH2:3][c:4]1[n:5][cH:6][cH:7][cH:8][n:9]1>CS(C)=O>[N:1]#[C:2][CH2:3][c:4]1[n:5][cH:6][cH:7][cH:8][n:9]1|EP3319962B1_0605
1.3.7|[N&H2&+0&D1:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&H1&+0&D2:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][S:9]([NH2:10])(=[O:11])=[O:12].[O:13]=[C:14]1[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[C:21]([c:22]2[c:23]1[cH:24][cH:25][cH:26][c:27]2Cl)=[O:28]>CC([O-])=O.CC([O-])=O.O=C(O[K])O[K].Clc1ccccc1Cl.[Cu+2]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][S:9](=[O:11])(=[O:12])[NH:10][c:27]1[cH:26][cH:25][cH:24][c:23]2[C:14]([c:15]3[cH:16][cH:17][cH:18][cH:19][c:20]3[C:21]([c:22]21)=[O:28])=[O:13]|US20200392149A1_0819
1.7.11|[O&H1&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[o:1])-Cl>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[o:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([OH:6])[C:7](=[O:8])[CH:9]([CH3:10])[O:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[OH:18].Cl[c:19]1[n:20][c:21]2[cH:22][c:23]([cH:24][cH:25][c:26]2[o:27]1)[Cl:28]>CC#N.O=C(O[K])O[K]>[CH3:1][O:2][C:3](=[O:4])[CH:5]([OH:6])[C:7](=[O:8])[CH:9]([CH3:10])[O:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[O:18][c:19]1[n:20][c:21]2[cH:22][c:23]([cH:24][cH:25][c:26]2[o:27]1)[Cl:28]|US06677364B2
3.2.1|[C&H2&+0&D1:5]=[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H1&+0&D2:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|Br[c:1]1[cH:2][cH:3][cH:4][cH:5][cH:6]1.[CH2:7]=[CH:8][C:9]([CH3:10])([CH3:11])[OH:12]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CC(C)N(CC)C(C)C.CN(C)C=O.O=C(O)O[Na].[Pd]>[CH3:10][C:9]([CH3:11])([OH:12])[CH:8]=[CH:7][c:1]1[cH:6][cH:5][cH:4][cH:3][cH:2]1|EP3204360B1_0575
9.7.111|[O&H0&+0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[O&H1&+0&D1:4]-[S&H0&+0&D3:3](=[O&H0&D1:2])-[c:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([c:7]([cH:8][c:9]1[Cl:10])[Cl:11])[S:12](=[O:13])(=[O:14])Cl>O.Cl.O=S(O[Na])O[Na].O[Na]>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([c:7]([cH:8][c:9]1[Cl:10])[Cl:11])[S:12](=[O:14])[OH:13]|US20140256756A1_0425
3.11.86|[C&H3&+0&D1:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H2&+0&D2:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[CH3:10][CH2:11][N:12]1[CH2:13][CH2:14][N:15]([CH2:16][CH2:17]1)[c:18]1[n:19][c:20]([cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]21)Br>O.CS(C)=O.CC(C)(C)O[K].[Hg]>[CH3:10][CH2:11][N:12]1[CH2:13][CH2:14][N:15]([CH2:16][CH2:17]1)[c:18]1[n:19][c:20]([cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]21)[CH2:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1|US20100286152A1_0674
1.8.12|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([s:9]1)Br.[O:10]=[C:11]([OH:12])[CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[SH:20]>O.CN(C)C=O.O[K]>[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([s:9]1)[S:20][c:17]1[cH:18][cH:19][c:14]([cH:15][cH:16]1)[CH2:13][C:11](=[O:10])[OH:12]|US08148400B2_0478
1.3.1|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[O:1]=[C:2]([NH:3][C@H:4]1[CH2:5][N:6]2[CH2:7][CH2:8][CH:9]1[CH2:10][CH2:11]2)[c:12]1[cH:13][cH:14][c:15]([s:16]1)Br.[NH2:17][c:18]1[cH:19][cH:20][cH:21][n:22][cH:23]1>c1ccc(cc1)P(c1ccccc1)c1ccc2ccccc2c1-c1c2ccccc2ccc1P(c1ccccc1)c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)(C)[O-].C1CCOC1.[Na+].Cl.[Pd].[Pd]>[O:1]=[C:2]([NH:3][C@H:4]1[CH2:5][N:6]2[CH2:11][CH2:10][CH:9]1[CH2:8][CH2:7]2)[c:12]1[cH:13][cH:14][c:15]([s:16]1)[NH:17][c:18]1[cH:23][n:22][cH:21][cH:20][cH:19]1|US08134000B2_0214
9.7.155|[C:4]-[C&H2&+0&D2:3]-Br.[N&H0&D1:2]#[C&H0&+0&D2:1]-[#19]>>[C:4]-[C&H2&+0&D2:3]-[C&H0&+0&D2:1]#[N&H0&D1:2]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]#[C:7][CH2:8]Br.[N:9]#[C:10][K]>O.CS(C)=O>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]#[C:7][CH2:8][C:10]#[N:9]|US20200299304A1_0677
9.7.265|[C&H3&D1:4]-[C&H1&+0&D3:3](-[C:2])-[N&H1&+0&D2:1]-C=O>>[C&H3&D1:4]-[C@&H1&+0&D3:3](-[C:2])-[N&H2&+0&D1:1]|[CH3:1][CH:2]([CH2:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[NH:11]C=O>>[CH3:1][C@H:2]([NH2:11])[CH2:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|US04786646A
3.3.2|[C&H1&+0&D1:5]#[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([cH:10]1)Br)[C:11]([F:12])([F:13])[F:14].[CH:15]#[C:16][CH2:17][N:18]1[CH2:19][CH2:20][CH:21]([CH2:22][CH2:23]1)[C:24]([CH3:25])([CH3:26])[CH3:27].[ClH:28]>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOCC.CCNCC.I[Cu]>[CH3:25][C:24]([CH3:26])([CH3:27])[CH:21]1[CH2:20][CH2:19][N:18]([CH2:23][CH2:22]1)[CH2:17][C:16]#[C:15][c:9]1[cH:10][c:5]([cH:6][c:7]([cH:8]1)[C:11]([F:12])([F:13])[F:14])[C:2]([F:1])([F:3])[F:4].[ClH:28]|EP3197879B1_0169
3.2.5|[C&H2&+0&D1:5]=[C:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C&H1&+0&D2:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH2:1]=[CH:2][C:3](=[O:4])[N:5]([CH:6]([CH3:7])[CH3:8])[CH:9]([CH3:10])[CH3:11].Br[c:12]1[cH:13][cH:14][cH:15][s:16]1>Cc1ccccc1P(c1ccccc1C)c1ccccc1C.CCCCN(CCCC)CCCC.CN(C)C=O.CCOCC.O>[CH3:10][CH:9]([CH3:11])[N:5]([C:3](=[O:4])[CH:2]=[CH:1][c:12]1[cH:13][cH:14][cH:15][s:16]1)[CH:6]([CH3:7])[CH3:8]|EP2243778B1_0051
3.3.3|[C&H1&+0&D1:5]#[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][c:3]1[cH:4][n:5][c:6]([n:7][cH:8]1)Cl.[CH:9]#[C:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.I[Cu].[I-]>[CH3:1][CH2:2][c:3]1[cH:4][n:5][c:6]([n:7][cH:8]1)[C:9]#[C:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US20180044343A1_0866
1.3.7|[N&H2&+0&D1:5]-[O:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[CH:2][NH:3][c:4]1[n:5][c:6]([c:7]([c:8]([n:9]1)[Cl:10])[NH:11][CH:12]=[O:13])Cl.[NH2:14][O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>CCN(CC)CC.C1COCCO1>[O:1]=[CH:2][NH:3][c:4]1[n:9][c:8]([c:7]([c:6]([n:5]1)[NH:14][O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[NH:11][CH:12]=[O:13])[Cl:10]|US20190389812A1_0655
1.3.6|[N&H2&+0&D1:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[N&H1&+0&D2:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH2:1][c:2]1[c:3]([cH:4][c:5]([c:6]2[c:7]1[C:8]([c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[C:15]2=[O:16])=[O:17])Br)[S:18]([O-:19])(=[O:20])=[O:21].[CH3:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[S:29]([NH2:30])(=[O:31])=[O:32].[Na+:33]>O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O[Na])O[Na].[O-]S([O-])(=O)=O.O=C(O)O[Na].O.O.O.O.O.O.O.[Cu+2]>[CH3:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[S:29](=[O:31])(=[O:32])[NH:30][c:5]1[cH:4][c:3]([c:2]([c:7]2[c:6]1[C:15]([c:14]1[cH:13][cH:12][cH:11][cH:10][c:9]1[C:8]2=[O:17])=[O:16])[NH2:1])[S:18]([O-:19])(=[O:20])=[O:21].[Na+:33]|US08575158B2_1140
1.6.2|[B&-:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[B&-:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][NH:11][C@@H:12]([CH2:13]1)[CH3:14].[F:15][B-:16]([F:17])([F:18])[CH2:19]Br.[O-]C([O-])=O.[K+].[K+].[K+:20]>C1CCOC1>[CH3:14][C@@H:12]1[CH2:13][N:8]([CH2:9][CH2:10][N:11]1[CH2:19][B-:16]([F:15])([F:17])[F:18])[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4].[K+:20]|US09828379B2_0871
1.8.12|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[o:1])-Br>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[SH:8].[O:9]=[C:10]([OH:11])[c:12]1[cH:13][o:14][c:15]([cH:16]1)Br>CN(C)C=O.[O-2].[Cu+].[Cu+]>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[S:8][c:15]1[cH:16][c:12]([cH:13][o:14]1)[C:10](=[O:9])[OH:11]|US09073879B2_0489
1.3.6|[N&H2&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[NH2:11].[O:12]=[c:13]1[nH:14][c:15]([n:16][c:17]2[n:18][cH:19][nH:20][c:21]21)Br>O.COCCO>[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[NH:11][c:15]1[n:16][c:17]2[n:18][cH:19][nH:20][c:21]2[c:13]([nH:14]1)=[O:12]|US10118904B2_0771
1.3.7|[N&H2&+0&D1:5]-[n:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&H1&+0&D2:5](-[n:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[ClH:1].[NH2:2][n:3]1[cH:4][cH:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]21)[N+:12]([O-:13])=[O:14].Cl[c:15]1[cH:16][cH:17][n:18][cH:19][cH:20]1>O.CC(C)O.O=C(O[Na])O[Na]>[ClH:1].[O-:13][N+:12](=[O:14])[c:8]1[cH:9][cH:10][c:11]2[c:6]([cH:5][cH:4][n:3]2[NH:2][c:15]2[cH:16][cH:17][n:18][cH:19][cH:20]2)[cH:7]1|EP0468401A2_0078
1.8.12|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])[SH:11].Br[c:12]1[cH:13][cH:14][s:15][cH:16]1>O.CN(C)C=O.[O-2].[NaH].[Cu+].[Cu+]>[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])[S:11][c:12]1[cH:13][cH:14][s:15][cH:16]1|US07544702B2_0506
9.7.157|[C:4]-[C&H2&+0&D2:3]-Cl.[N&H0&D1:2]#[C&H0&+0&D2:1]-[#11]>>[C:4]-[C&H2&+0&D2:3]-[C&H0&+0&D2:1]#[N&H0&D1:2]|[CH3:1][C:2](=[O:3])[CH2:4][CH2:5][C:6]#[C:7][CH2:8][CH2:9][CH2:10]Cl.[N:11]#[C:12][Na]>O.CCO.CCOCC.O[Na]>[CH3:1][C:2](=[O:3])[CH2:4][CH2:5][C:6]#[C:7][CH2:8][CH2:9][CH2:10][C:12]#[N:11]|US07531683B2_0059
1.2.9|[C:5]-[C@&H1&+0&D3:4](-[C:3])-O.[C:2]-[N&H2&+0&D1:1]>>[C:5]-[C@@&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C@H:6](O)[CH2:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH3:15][CH:16]([CH3:17])[CH2:18][C@H:19]([NH2:20])[C:21](=[O:22])[O:23][CH3:24]>O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.Cc1cccc(n1)C.ClCCl>[CH3:24][O:23][C:21](=[O:22])[C@H:19]([CH2:18][CH:16]([CH3:15])[CH3:17])[NH:20][C@@H:6]([CH2:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1]|EP1836163B1_0216
1.8.13|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])Cl.[SH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>CN(C)C=O.[NaH]>[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])[S:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US20090069408A1_0630
3.8.2|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13](=O)[c:14]1[cH:15][o:16][c:17]([cH:18]1)[Si:19]([CH3:20])([CH3:21])[CH3:22].[CH3:23][CH2:24][O:25][C:26](=[O:27])[CH2:28]Br>CC(=O)OC(C)=O.c1ccccc1.[Zn]>[CH3:20][Si:19]([CH3:21])([CH3:22])[c:17]1[cH:18][c:14]([cH:15][o:16]1)[C:13](=[CH:28][C:26](=[O:27])[O:25][CH2:24][CH3:23])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH3:1]|US07605171B2_0396
1.3.7|[N&H2&+0&D1:5]-[N:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[N:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][c:9]([c:10]([c:11]1[Cl:12])[N+:13]([O-:14])=[O:15])Cl)[CH3:16].[CH3:17][CH2:18][NH:19][NH2:20]>O.CCN(CC)CC.CO>[CH3:17][CH2:18][NH:19][NH:20][c:9]1[n:8][c:7]([c:6]([c:11]([c:10]1[N+:13]([O-:14])=[O:15])[Cl:12])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[CH3:16]|US20190185479A1_1932
1.8.13|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[SH:11].Cl[c:12]1[cH:13][cH:14][cH:15][c:16]([n:17]1)[Cl:18]>[Na+].CC(=O)Nc1ccc(cc1)S.C[O-].CS(C)=O.[Na]>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[S:11][c:12]1[cH:13][cH:14][cH:15][c:16]([n:17]1)[Cl:18]|US07196202B2_0246
9.7.157|[N&H0&D1:4]#[C&H0&+0&D2:3]-[#19].[c:2]-[C&H2&+0&D2:1]-Cl>>[N&H0&D1:4]#[C&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[N:1]#[C:2][K].Cl[CH2:3][c:4]1[cH:5][cH:6][c:7]2[O:8][c:9]3[n:10][cH:11][cH:12][cH:13][c:14]3[CH2:15][c:16]2[cH:17]1>O.CN(C)C=O>[N:1]#[C:2][CH2:3][c:4]1[cH:5][cH:6][c:7]2[O:8][c:9]3[n:10][cH:11][cH:12][cH:13][c:14]3[CH2:15][c:16]2[cH:17]1|US20200331917A1_0350
1.3.6|[N&H2&+0&D1:5]-[S:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[N&H1&+0&D2:5](-[S:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Br:1][c:2]1[cH:3][cH:4][n:5][c:6]([n:7]1)Br.[CH3:8][N:9]([CH3:10])[S:11]([NH2:12])(=[O:13])=[O:14]>CC1(c2cccc(c2Oc2c1cccc2P(c1ccccc1)c1ccccc1)P(c1ccccc1)c1ccccc1)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(O[Cs])O[Cs].C1COCCO1.[Pd].[Pd]>[CH3:8][N:9]([CH3:10])[S:11](=[O:13])(=[O:14])[NH:12][c:6]1[n:5][cH:4][cH:3][c:2]([n:7]1)[Br:1]|US10736883B2_1365
10.1.4|[I&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][O:2]/[N:3]=[C:4](\[C:5](=[O:6])[OH:7])[c:8]1[cH:9][s:10][c:11]([n:12]1)[NH:13][C:14](=[O:15])[CH2:16][Cl:17].O=C1CCC(N1[I:18])=O>CC(=O)N(C)C>[CH3:1][O:2]/[N:3]=[C:4](\[C:5](=[O:6])[OH:7])[c:8]1[n:12][c:11]([s:10][c:9]1[I:18])[NH:13][C:14](=[O:15])[CH2:16][Cl:17]|US20200323819A1_0302
1.7.11|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH:2]([O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[OH:10])[C:11](=[O:12])[OH:13].[F:14][C:15]([F:16])([F:17])[c:18]1[cH:19][n:20][c:21]([c:22]([cH:23]1)[F:24])Br>CS(C)=O.O[Na].O.Cl>[CH3:1][CH:2]([O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][c:21]1[n:20][cH:19][c:18]([cH:23][c:22]1[F:24])[C:15]([F:14])([F:16])[F:17])[C:11](=[O:12])[OH:13]|US07282501B2_1006
3.3.3|[C&H1&+0&D1:5]#[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[N+:11]([O-:12])=[O:13])Cl.[CH:14]#[C:15][CH2:16][CH2:17][CH3:18]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCN(CC)CC.Cl[Pd]Cl>[CH3:18][CH2:17][CH2:16][C:15]#[C:14][c:8]1[cH:7][cH:6][c:5]([cH:10][c:9]1[N+:11]([O-:12])=[O:13])[C:3](=[O:4])[O:2][CH3:1]|EP3109234A1_0302
1.8.12|[S&H1&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[s:7][c:8]([n:9][c:10]1[CH3:11])Br.[SH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>CN(C)C=O.O=C(O[K])O[K]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[s:7][c:8]([n:9][c:10]1[CH3:11])[S:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|US20200016140A1_0228
9.7.155|[N&H0&D1:4]#[C&H0&+0&D2:3]-[#19].[c:2]-[C&H2&+0&D2:1]-Br>>[N&H0&D1:4]#[C&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[N:1]#[C:2][K].[F:3][C:4]([F:5])([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[C:12]([F:13])([F:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[CH2:21]Br>O.CC(C)=O>[N:1]#[C:2][CH2:21][c:20]1[cH:19][cH:18][cH:17][cH:16][c:15]1[C:12]([F:13])([F:14])[C:4]([F:3])([F:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1|US20200331917A1_1243
3.3.2|[C&H1&+0&D1:5]#[C:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH:1]#[C:2][CH2:3][OH:4].Br[c:5]1[n:6][cH:7][cH:8][s:9]1>CC#N.I[Cu]>[OH:4][CH2:3][C:2]#[C:1][c:5]1[n:6][cH:7][cH:8][s:9]1|US20190225638A1_0569
1.7.11|[O&H1&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([s:10]1)Br.[OH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>CN(C)C=O.O=C(O[K])O[K]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([s:10]1)[O:11][c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US20200347020A1_0440
1.7.11|[O&H1&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[OH:14].Cl[c:15]1[n:16][cH:17][cH:18][s:19]1>CN(C)C=O.O=C(O[K])O[K]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[O:14][c:15]1[n:16][cH:17][cH:18][s:19]1|US07935725B2_0239
3.9.12|[C:4]-[C&H1&+0&D2:3]=C.[Cl&H0&D1:2]/[C&H1&+0&D2:1]=C\Cl>>[C:4]/[C&H1&+0&D2:3]=[C&H1&+0&D2:1]\[Cl&H0&D1:2]|C=[CH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][Br:8].Cl/C=[CH:9]\[Cl:10]>c1ccccc1>[Cl:10]/[CH:9]=[CH:1]\[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][Br:8]|US20190314799A1_0291
10.1.4|[I&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[I&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][n:2]1[c:3]([n:4][c:5]([cH:6][c:7]1=[O:8])-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[NH2:15].O=C1CCC(N1[I:16])=O>CC(=O)O>[CH3:1][n:2]1[c:3]([n:4][c:5]([c:6]([c:7]1=[O:8])[I:16])-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[NH2:15]|US09273058B2_0538
1.6.4|[N&H1&+0&D1:5]=[S:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H0&+0&D2:5](=[S:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C@@H:2]1[CH2:3][O:4][CH2:5][CH2:6][N:7]1[c:8]1[cH:9][c:10]([n:11][c:12]([n:13]1)[Cl:14])Cl.[CH3:15][S:16](=[NH:17])(=[O:18])[CH:19]1[CH2:20][CH2:21]1>CC1(c2cccc(c2Oc2c1cccc2P(c1ccccc1)c1ccccc1)P(c1ccccc1)c1ccccc1)C.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(O[Cs])O[Cs].C1COCCO1.[Pd].[Pd]>[CH3:1][C@@H:2]1[CH2:3][O:4][CH2:5][CH2:6][N:7]1[c:8]1[cH:9][c:10]([n:11][c:12]([n:13]1)[Cl:14])[N:17]=[S:16]([CH3:15])(=[O:18])[CH:19]1[CH2:20][CH2:21]1|US20190233425A1_3067
1.7.11|[O&H1&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Cl:1][c:2]1[n:3][c:4]([n:5][c:6]([n:7]1)Cl)[Cl:8].[OH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>ClC(Cl)Cl.O[Na]>[Cl:1][c:2]1[n:3][c:4]([n:5][c:6]([n:7]1)[O:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[Cl:8]|US09643965B2_0388
1.3.7|[N&H2&+0&D1:5]-[c:4].[N:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[N:3])-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[Br:8].[O:9]=[S:10]1([N:11]=[C:12]([c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]21)Cl)=[O:19]>CC(C)=O>[O:9]=[S:10]1([N:11]=[C:12]([c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]21)[NH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[Br:8])=[O:19]|US20190292160A1_0292
3.3.2|[C&H1&+0&D1:5]#[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H0&+0&D2:5](#[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH:1]#[C:2][CH2:3][CH2:4][OH:5].Br[c:6]1[n:7][cH:8][cH:9][cH:10][n:11]1>CCOCC.CC#N.C1CCC(CC1)NC1CCCCC1.[Cu]>[OH:5][CH2:4][CH2:3][C:2]#[C:1][c:6]1[n:7][cH:8][cH:9][cH:10][n:11]1|US20200283446A1_0411
1.7.8|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([s:7][c:8]1Cl)[Cl:9].[OH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O.[Na+].CN(C)C=O.I[Cu].[H-]>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([s:7][c:8]1[O:10][c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1)[Cl:9]|US09481688B2_0043
1.8.13|[S&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[S&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[n:6][cH:7][c:8]([s:9]1)Cl.[O-:10][N+:11](=[O:12])[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[SH:19]>O.O.CN(C)C=O.O=C(O[K])O[K]>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[n:6][cH:7][c:8]([s:9]1)[S:19][c:16]1[cH:17][cH:18][c:13]([cH:14][cH:15]1)[N+:11]([O-:10])=[O:12]|US09382254B2_1481
9.7.40|[N&+:5]=[N&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&+:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]1)[n:8][cH:9][c:10]([c:11]2Cl)[C:12](=[O:13])[O:14][CH2:15][CH3:16].[N-:17]=[N+:18]=[N-:19]>O>[CH3:16][CH2:15][O:14][C:12](=[O:13])[c:10]1[cH:9][n:8][c:6]2[n:7][c:2]([cH:3][cH:4][c:5]2[c:11]1[N:19]=[N+:18]=[N-:17])[CH3:1]|US20190345161A1_0398
9.7.40|[N&+:5]=[N&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&+:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Na+].[CH3:1][CH2:2][CH2:3][c:4]1[c:5]([n:6][cH:7][n:8][c:9]1Cl)[CH2:10][n:11]1[cH:12][cH:13][n:14][c:15]1-[c:16]1[cH:17][cH:18][cH:19][c:20]([n:21]1)[F:22].[N-:23]=[N+:24]=[N-:25]>CN(C)C=O>[CH3:1][CH2:2][CH2:3][c:4]1[c:5]([n:6][cH:7][n:8][c:9]1[N:25]=[N+:24]=[N-:23])[CH2:10][n:11]1[cH:12][cH:13][n:14][c:15]1-[c:16]1[cH:17][cH:18][cH:19][c:20]([n:21]1)[F:22]|US20080312192A1_0485
3.11.91|[C:5]-[C&H1&+0&D3:4](-[O:3])-[C:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[C&H0&+0&D4:4]1(-[O:3])-[C&H2&+0&D2:1]-[C:2]-1|[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH2:6][CH2:7]Br)[O:8][c:9]1[cH:10][c:11]([c:12]([cH:13][c:14]1[Cl:15])[F:16])-[n:17]1[c:18]([cH:19][c:20]([n:21]([c:22]1=[O:23])[CH3:24])[C:25]([F:26])([F:27])[F:28])=[O:29]>CC(C)(C)[O-].C1CCOC1.[K+]>[CH3:24][n:21]1[c:20]([cH:19][c:18]([n:17]([c:22]1=[O:23])-[c:11]1[cH:10][c:9]([c:14]([cH:13][c:12]1[F:16])[Cl:15])[O:8][C:5]1([CH2:6][CH2:7]1)[C:3](=[O:4])[O:2][CH3:1])=[O:29])[C:25]([F:26])([F:27])[F:28]|US10689331B2_0576
9.7.12|[N&H2&+0&D1:4]-[c:3].[S&H0&D1:2]=[C&H0&+0&D3:1](-Cl)-Cl>>[N&H0&+0&D2:4](-[c:3])=[C&H0&+0&D2:1]=[S&H0&D1:2]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][n:7]1)[Cl:8].[S:9]=[C:10](Cl)Cl>O.CCOCC.[O-]C([O-])=O.[Ca+2]>[S:9]=[C:10]=[N:1][c:2]1[cH:3][cH:4][c:5]([cH:6][n:7]1)[Cl:8]|EP3529331B1_0212
3.11.16|[c:5]:[c&H0&+0&D3:4](:[c:3])-Br.[c:2]-[C&H2&+0&D2:1]-Cl>>[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][C:8](=[O:9])[NH:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[CH2:17]Cl.[CH3:18][CH:19]([CH3:20])[O:21][CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)Br>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCCC[Sn](Cl)(CCCC)CCCC.CN(C)P(=O)(N(C)C)N(C)C.CCCCC.CC(C)(C)[Li].C1CCOC1>[CH3:18][CH:19]([CH3:20])[O:21][CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[CH2:17][c:14]1[cH:13][cH:12][c:11]([cH:16][cH:15]1)[NH:10][C:8](=[O:9])[O:7][CH2:6][CH2:5][Si:2]([CH3:1])([CH3:3])[CH3:4]|US20200297703A1_0201
3.11.16|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][n:8][c:9]([c:10]2[cH:11][c:12]([s:13][c:14]12)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[Cl:21])Cl.[CH3:22][C:23]([CH3:24])([CH3:25])[O:26][C:27](=[O:28])[N:29]1[CH2:30][CH2:31][CH:32]([CH2:33]1)[CH2:34]Br>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][n:8][c:9]([c:10]2[cH:11][c:12]([s:13][c:14]12)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[Cl:21])[CH2:34][CH:32]1[CH2:31][CH2:30][N:29]([CH2:33]1)[C:27](=[O:28])[O:26][C:23]([CH3:22])([CH3:24])[CH3:25]|US20110046127A1_0732
2.5.7|[N&H2&+0&D1:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-S-C>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|CS[c:1]1[n:2][n:3][cH:4][c:5]2[cH:6][n:7][cH:8][n:9]21.[NH2:10][c:11]1[cH:12][cH:13][nH:14][n:15]1>Cc1ccccc1>[cH:8]1[n:7][cH:6][c:5]2[cH:4][n:3][n:2][c:1]([n:9]12)[NH:10][c:11]1[cH:12][cH:13][nH:14][n:15]1|US08710065B2_0782
3.9.5|[C&H3&+0&D1:4]-I.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][N:2]1[CH2:3][CH2:4][CH2:5][CH2:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]21)[CH:13]=[O:14].[CH3:15]I>[NH4+].[Cl-].CCOCC.[Mg]>[CH3:1][N:2]1[CH2:3][CH2:4][CH2:5][CH2:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]21)[CH:13]([CH3:15])[OH:14]|EP3050876A2_0359
3.11.16|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5]Br.[CH3:6][C:7]1([O:8][CH2:9][CH2:10][O:11]1)[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)Br>[NH4+].O.[Cl-].BrCCBr.II.C1CCOC1.[Mg]>[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5][c:15]1[cH:14][cH:13][c:12]([cH:17][cH:16]1)[C:7]1([O:8][CH2:9][CH2:10][O:11]1)[CH3:6]|EP3371291B1_0032
2.5.7|[N&H2&+0&D1:5]-[c:4].[N:3]-[C&H0&+0&D3:2](=[N:1])-S-C>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](-[N:3])=[N:1]|[CH3:1][C:2](=[O:3])[NH:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[NH2:14])[O:15][S:16](=[O:17])(=[O:18])[c:19]1[cH:20][cH:21][cH:22][c:23]([cH:24]1)[C:25]([F:26])([F:27])[F:28].[CH3:29][O:30][C:31](=[O:32])[N:33]=[C:34]([NH:35][C:36](=[O:37])[O:38][CH3:39])SC>Cc1ccc(cc1)S(=O)(=O)O>[CH3:29][O:30][C:31](=[O:32])[N:33]=[C:34]([NH:35][C:36](=[O:37])[O:38][CH3:39])[NH:14][c:13]1[cH:12][c:11]([cH:10][cH:9][c:8]1[NH:7][C:5](=[O:6])[NH:4][C:2]([CH3:1])=[O:3])[O:15][S:16](=[O:17])(=[O:18])[c:19]1[cH:24][c:23]([cH:22][cH:21][cH:20]1)[C:25]([F:26])([F:27])[F:28]|US20050234081A1_1045
8.7.2|[C&H2&+0&D1:4]=[C&H1&+0&D2:3]-[C:2].[O&H0&+0&D1:1]=O>>[C&H3&+0&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]|[CH2:1]=[CH:2][CH2:3][C@@H:4]1[CH2:5][C:6]([N@@:7]([CH2:8]1)[CH:9]([CH2:10][CH3:11])[C:12]([NH2:13])=[O:14])=[O:15].O=[O:16]>O.CN1CCCC1=O.Cl[Cu]Cl.Cl[Pd]Cl>[CH3:11][CH2:10][CH:9]([C:12]([NH2:13])=[O:14])[N@@:7]1[CH2:8][C@@H:4]([CH2:5][C:6]1=[O:15])[CH2:3][C:2]([CH3:1])=[O:16]|US20190270741A1_0637
9.7.11|[N&H2&+0&D1:4]-[c:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-Cl)-Cl>>[N&H0&+0&D2:4](-[c:3])=[C&H0&+0&D2:1]=[O&H0&D1:2]|[CH3:1][c:2]1[n:3][n:4][c:5]([s:6]1)[NH2:7].[O:8]=[C:9](Cl)Cl>CCOC(C)=O>[CH3:1][c:2]1[n:3][n:4][c:5]([s:6]1)[N:7]=[C:9]=[O:8]|US20200190075A1_0199
9.7.23|[C:5]-[C&H1&+0&D3:4](-[C:3])-Br.[N&+:2]=[N&H0&-&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11](Br)[C:12](=[O:13])[O:14][CH3:15].[N-:16]=[N+:17]=[N-:18]>CC#N>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]([N:18]=[N+:17]=[N-:16])[C:12](=[O:13])[O:14][CH3:15]|US08497288B2_0236
3.11.16|[c:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[c:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[n:6][c:7]2[cH:8][cH:9][cH:10][cH:11][n:12]2[c:13]1Br.[N:14]#[C:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[CH2:22]Br.[Zn]>O.C1CCOC1.[Pd]>[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[n:6][c:7]2[cH:8][cH:9][cH:10][cH:11][n:12]2[c:13]1[CH2:22][c:19]1[cH:18][cH:17][c:16]([cH:21][cH:20]1)[C:15]#[N:14]|US20200031800A1_0191
9.5.4|[C:5]-[C@@&H0&+0&D4:4](-[c:3])(-[C&H2&+0&D2:2]-[C:1])-O>>[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[C:1]|[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[CH2:11][CH2:12][C@H:13]1[C@@H:14]3[CH2:15][CH2:16][C:17]([C@:18]3([CH2:19][CH2:20][C@:21]21O)[CH3:22])=[O:23]>CC(=O)O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+](=O)O.[O-][N+](=O)O.N.N.O.[Ce+4]>[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]2[C:21]3=[CH:20][CH2:19][C@@:18]4([C:17]([CH2:16][CH2:15][C@H:14]4[C@@H:13]3[CH2:12][CH2:11][c:9]2[cH:10]1)=[O:23])[CH3:22]|US20150065705A1_0635
3.11.16|[c:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|Cl[c:1]1[cH:2][cH:3][n:4][c:5]([n:6]1)[Cl:7].Br[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>>[Cl:7][c:5]1[n:4][cH:3][cH:2][c:1]([n:6]1)[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US20020035092A1_0343
3.11.16|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|Br[c:1]1[n:2][cH:3][cH:4][cH:5][c:6]1[O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH3:15][CH2:16][CH2:17]Br>c1ccc(cc1)P(CCP(c1ccccc1)c1ccccc1)c1ccccc1.CCOCC.CCCBr.Cl[Ni]Cl.II.O.[Mg]>[CH3:15][CH2:16][CH2:17][c:1]1[n:2][cH:3][cH:4][cH:5][c:6]1[O:7][CH2:8][c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1|EP3016960B1_0256
3.11.16|[c:5]:[c&H0&+0&D3:4](:[c:3])-Br.[c:2]-[C&H2&+0&D2:1]-Br>>[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[c:4]([c:5]([c:6]([c:7]([c:8]1[CH3:9])[CH2:10]Br)[O:11][CH3:12])[CH3:13])[CH3:14].Br[c:15]1[cH:16][n:17][cH:18][cH:19][cH:20]1>O.CCOCC.CCCC[Li]>[CH3:1][O:2][c:3]1[c:4]([c:5]([c:6]([c:7]([c:8]1[CH3:9])[CH2:10][c:15]1[cH:20][cH:19][cH:18][n:17][cH:16]1)[O:11][CH3:12])[CH3:13])[CH3:14]|EP2593427B1_0355
3.11.16|[C:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5]Cl.[Cl:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)Br>[NH4+].[Cl-].CCBr.II.C1CCOC1.[Mg]>[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5][c:10]1[cH:11][cH:12][c:7]([cH:8][cH:9]1)[Cl:6]|EP3091024B1_0172
9.7.33|[N&H3&+0&D0:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[O&-]>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[NH3:1].[O-][C:2](=[O:3])[CH2:4][N:5]1[CH2:6][CH:7]([CH2:8][C:9]1=[O:10])[OH:11]>>[NH2:1][C:2](=[O:3])[CH2:4][N:5]1[CH2:6][CH:7]([CH2:8][C:9]1=[O:10])[OH:11]|US20200055848A1_0355
9.5.4|[c:5]-[C&H0&+0&D4:4]1(-[C&H2&+0&D2:3]-[C:2]-[C:1]-1)-O>>[c:5]-[C&H0&+0&D3:4]1=[C&H1&+0&D2:3]-[C:2]-[C:1]-1|[CH3:1][CH2:2][CH2:3][C@@H:4]1[CH2:5][CH2:6][C@H:7]([CH2:8][CH2:9]1)[CH:10]1[CH2:11][C:12]2([CH2:13]1)[CH2:14][C:15]([CH2:16]2)(O)[c:17]1[cH:18][c:19]([c:20]([c:21]([cH:22]1)[F:23])[F:24])[F:25]>Cc1ccc(cc1)S(=O)(=O)O.Cc1ccccc1.O>[CH3:1][CH2:2][CH2:3][C@@H:4]1[CH2:5][CH2:6][C@H:7]([CH2:8][CH2:9]1)[CH:10]1[CH2:11][C:12]2([CH:14]=[C:15]([CH2:16]2)[c:17]2[cH:18][c:19]([c:20]([c:21]([cH:22]2)[F:23])[F:24])[F:25])[CH2:13]1|US20190127362A1_0930
9.7.23|[N&+:5]=[N&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[N&+:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C:9]1[CH2:10][O:11][CH2:12][C:13]([N:14]=1)([CH2:15][F:16])[c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)Br.[N-:23]=[N+:24]=[N-:25].[Na+]>[O-]C1=C(C(O[C@@H]1[C@@H](O)CO)=O)O.CNC1CCCCC1NC.CCO.I[Cu].O.[Na+]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C:9]1[CH2:10][O:11][CH2:12][C:13]([N:14]=1)([CH2:15][F:16])[c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)[N:25]=[N+:24]=[N-:23]|US20090099207A1_0269
3.9.44|[C:5]=[C&H1&+0&D2:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-C(=O)-O>>[C:5]=[C&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[O:1]=[C:2]1[C:3](=[CH:4][C:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12)=[O:12])[OH:13].[CH3:14][C:15]([CH3:16])([CH3:17])[CH2:18]C(=O)O>[O-]OS([O-])(=O)=O.[O-][N+](=O)O[Ag].CC#N.[NH4+].[NH4+].O>[CH3:14][C:15]([CH3:16])([CH3:17])[CH2:18][C:4]1=[C:3]([C:2]([c:11]2[cH:10][cH:9][cH:8][cH:7][c:6]2[C:5]1=[O:12])=[O:1])[OH:13]|EP1933821B1_0125
9.7.33|[N&H3&+0&D0:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[N&H2&+0&D1:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH3:1].[CH3:2][CH2:3][CH:4]1[CH2:5][n:6]2[c:7]([n:8][cH:9][c:10]([c:11]2=[O:12])[C:13]([O-])=[O:14])-[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21>>[CH3:2][CH2:3][CH:4]1[CH2:5][n:6]2[c:11]([c:10]([cH:9][n:8][c:7]2-[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21)[C:13]([NH2:1])=[O:14])=[O:12]|US20150057260A1_1252
10.1.2|[C:4]-[C&H1&+0&D2:3]=[N:2].[Cl&H0&+0&D1:1]-N1-C(=O)-C-C-C-1=O>>[C:4]-[C&H0&+0&D3:3](-[Cl&H0&+0&D1:1])=[N:2]|[CH3:1][CH:2]([CH3:3])[C@@H:4]([CH:5]=[N:6][OH:7])[NH:8][C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15].O=C1CCC(N1[Cl:16])=O>CN(C)C=O.O>[CH3:1][CH:2]([CH3:3])[C@H:4]([NH:8][C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[C:5]([Cl:16])=[N:6][OH:7]|US20190322665A1_1430
10.1.1|[Br&H0&+0&D1:5]-Br.[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[Br&H0&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:12]([CH2:13][CH2:14][CH2:15][CH:16]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[O:22][C:23]([CH3:24])=[O:25])[C:26]([CH3:27])=[O:28].[Br:29]Br>ClC(Cl)(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([Br:29])([CH2:13][CH2:14][CH2:15][CH:16]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[O:22][C:23]([CH3:24])=[O:25])[C:26]([CH3:27])=[O:28]|US20200338209A1_1122
10.1.5|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[C:3]-[C&H2&+0&D2:2]-[O:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[O:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH2:7][O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][n:14]1)[Cl:15].O=C1CCC(N1[Br:16])=O>ClC(Cl)(Cl)Cl>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH:7]([Br:16])[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][n:14]1)[Cl:15]|US20100113513A1_0295
1.3.7|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n&+:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n&+:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][n+:7]1[c:8]([cH:9][c:10]([c:11]([c:12]1Cl)[C:13]#[N:14])[NH:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[NH2:22].[CH3:23][CH2:24][CH2:25][CH2:26][NH2:27].[Cl-:28]>CCN(CC)CC.CO>[CH3:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][NH:15][c:10]1[cH:9][c:8]([n+:7]([c:12]([c:11]1[C:13]#[N:14])[NH:27][CH2:26][CH2:25][CH2:24][CH3:23])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH3:1])[NH2:22].[Cl-:28]|US20170369492A1_0585
1.7.9|[O&H1&+0&D1:5]-[c:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-Br>>[O&H0&+0&D2:5](-[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[OH:10].Br[CH:11]1[CH2:12][CH2:13]1>>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[O:10][CH:11]1[CH2:12][CH2:13]1|US10851072B2_0142
10.1.2|[Cl&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[N:3]=[C&H1&+0&D2:2]-[c:1]>>[Cl&H0&+0&D1:4]-[C&H0&+0&D3:2](=[N:3])-[c:1]|O=C1CCC(N1[Cl:1])=O.[OH:2][N:3]=[CH:4][c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[Cl:11])[Cl:12]>O.CN(C)C=O>[OH:2][N:3]=[C:4]([Cl:1])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[Cl:11])[Cl:12]|US20200131129A1_0602
10.1.2|[C:4]-[C&H2&+0&D2:3]-[C:2].[Cl&H0&+0&D1:1]-N1-C(=O)-C-C-C-1=O>>[C:4]-[C&H1&+0&D3:3](-[C:2])-[Cl&H0&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18](=[O:19])[OH:20].O=C1CCC(N1[Cl:21])=O>N#CC(C#N)=c1ccc(cc1)=C(C#N)C#N.O=S(=O)(O)Cl.ClC(Cl)Cl>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([Cl:21])[C:18](=[O:19])[OH:20]|EP1764098A1_0110
10.1.1|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[n:3][cH:4][c:5]2[CH2:6][N:7]=[C:8]([c:9]3[cH:10][c:11]([cH:12][cH:13][c:14]3-[n:15]12)[Cl:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[F:23].O=C1CCC(N1[Br:24])=O>CC(=O)O.ClC(Cl)Cl>[CH3:1][c:2]1[n:3][c:4]([c:5]2[CH2:6][N:7]=[C:8]([c:9]3[cH:10][c:11]([cH:12][cH:13][c:14]3-[n:15]12)[Cl:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[F:23])[Br:24]|EP3240546B1_0245
1.7.11|[C:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n&+:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n&+:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([n+:7]1[O-:8])Cl.[OH:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O.Cl.CS(C)=O.ClC(Cl)Cl.[NaH]>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([n+:7]1[O-:8])[O:9][CH2:10][c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US09221843B2_1837
9.7.59|[C:4]-[#14&H0&+0&D4:3](-[Cl&H0&D1:2])(-[Cl&H0&D1:1])-Cl>>[C:4]-[#14&H1&+0&D3:3](-[Cl&H0&D1:2])-[Cl&H0&D1:1]|[F:1][C:2]([F:3])([F:4])[CH2:5][CH2:6][Si:7]([Cl:8])([Cl:9])Cl>CCCC[N+](CCCC)(CCCC)CCCC.FC(F)(F)CC[Si](Cl)(Cl)Cl.C[SiH](C)Cl.[Cl-]>[F:1][C:2]([F:3])([F:4])[CH2:5][CH2:6][SiH:7]([Cl:8])[Cl:9]|US20120114544A1_0108
10.1.1|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[N:7][O:8][CH3:9])[c:10]1[cH:11][s:12][c:13]([n:14]1)[NH:15][CH:16]=[O:17].O=C1CCC(N1[Br:18])=O>O=C(OOC(=O)c1ccccc1)c1ccccc1.c1ccccc1>[CH3:9][O:8][N:7]=[C:6]([C:4](=[O:5])[O:3][CH2:2][CH3:1])[c:10]1[n:14][c:13]([s:12][c:11]1[Br:18])[NH:15][CH:16]=[O:17]|EP3660023A1_0124
10.1.5|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[O:3]-[C&H2&+0&D2:2]-[c:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[O:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[C:6]([O:7][CH2:8][c:9]2[cH:10][c:11]1[O:12][CH3:13])=[O:14].O=C1CCC(N1[Br:15])=O>ClC(Cl)(Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][c:5]2[C:6]([O:7][CH:8]([c:9]2[cH:10][c:11]1[O:12][CH3:13])[Br:15])=[O:14]|US20200399261A1_0199
10.1.1|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[F:8].O=C1CCC(N1[Br:9])=O>ClCCl>[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[F:8])[Br:9]|EP3515912B1_0590
10.1.1|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[C:10](=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)-[n:18]1[cH:19][n:20][n:21][c:22]1[CH2:23][N:24]1[C:25]([c:26]2[cH:27][cH:28][cH:29][cH:30][c:31]2[C:32]1=[O:33])=[O:34].O=C1CCC(N1[Br:35])=O>>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[C:10](=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)-[n:18]1[c:19]([n:20][n:21][c:22]1[CH2:23][N:24]1[C:32]([c:31]2[cH:30][cH:29][cH:28][cH:27][c:26]2[C:25]1=[O:34])=[O:33])[Br:35]|US20200163970A1_0631
10.1.2|[C:4]-[C&H1&+0&D2:3]=[C:2].[Cl&H0&+0&D1:1]-N1-C(=O)-C-C-C-1=O>>[C:4]-[C&H0&+0&D3:3](=[C:2])-[Cl&H0&+0&D1:1]|[CH3:1][C:2]1([O:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[C@H:10]([C@@H:11]1[OH:12])[NH:13][C:14]1=[CH:15][C:16]([CH2:17][CH2:18]1)=[O:19])[C:20]#[N:21])[CH3:22].O=C1CCC(N1[Cl:23])=O>C1COCCO1.ClCCl>[CH3:1][C:2]1([O:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[C@H:10]([C@@H:11]1[OH:12])[NH:13][C:14]1[CH2:18][CH2:17][C:16]([C:15]=1[Cl:23])=[O:19])[C:20]#[N:21])[CH3:22]|US20200196600A1_1025
10.1.2|[Cl&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[Cl&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][c:11]([cH:12][cH:13][c:14]1-[n:15]1[cH:16][n:17][n:18][c:19]1[CH2:20][N:21]1[C:22]([c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[C:29]1=[O:30])=[O:31])[Br:32].O=C1CCC(N1[Cl:33])=O>c1ccccc1>[O:30]=[C:29]1[c:28]2[cH:27][cH:26][cH:25][cH:24][c:23]2[C:22]([N:21]1[CH2:20][c:19]1[n:18][n:17][c:16]([n:15]1-[c:14]1[cH:13][cH:12][c:11]([cH:10][c:9]1[C:2](=[O:1])[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[Br:32])[Cl:33])=[O:31]|US20200323209A1_0393
10.1.1|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[C:3]-[C&H1&+0&D2:2]=[C:1]>>[Br&H0&+0&D1:4]-[C&H0&+0&D3:2](-[C:3])=[C:1]|[CH3:1][CH2:2][S:3][C:4]1=[CH:5][CH2:6][C@H:7]2[C@@H:8]3[CH2:9][CH2:10][C:11]4=[CH:12][C:13]([CH:14]=[CH:15][C@@:16]4([C@:17]3([C@H:18]([CH2:19][C@:20]12[CH3:21])[OH:22])[F:23])[CH3:24])=[O:25].O=C1CCC(N1[Br:26])=O>ClCCl>[CH3:1][CH2:2][S:3][C:4]1=[C:5]([CH2:6][C@H:7]2[C@@H:8]3[CH2:9][CH2:10][C:11]4=[CH:12][C:13]([CH:14]=[CH:15][C@@:16]4([C@:17]3([C@H:18]([CH2:19][C@:20]12[CH3:21])[OH:22])[F:23])[CH3:24])=[O:25])[Br:26]|US20200196600A1_1007
4.2.8|[C&H2&+0&D1:4]=[C&H1&+0&D2:3]-[c:2].[O&H1&+0&D1:1]-O>>[C&H2&+0&D2:4]1-[O&H0&+0&D2:1]-[C&H1&+0&D3:3]-1-[c:2]|[CH2:1]=[CH:2][c:3]1[c:4]([c:5]([n:6][c:7]([c:8]1[C:9](=[O:10])[O:11][CH3:12])[CH:13]([F:14])[F:15])[C:16]([F:17])([F:18])[F:19])[C:20](=[O:21])[O:22][CH2:23][CH3:24].O[OH:25]>O=C(O)O[Na].CCO>[CH3:24][CH2:23][O:22][C:20](=[O:21])[c:4]1[c:5]([n:6][c:7]([c:8]([c:3]1[CH:2]1[CH2:1][O:25]1)[C:9](=[O:10])[O:11][CH3:12])[CH:13]([F:14])[F:15])[C:16]([F:17])([F:18])[F:19]|US07220870B2_0463
10.1.2|[Cl&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[Cl&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)-[c:11]1[cH:12][cH:13][n:14][c:15]2[cH:16][n:17][cH:18][n:19]21.O=C1CCC(N1[Cl:20])=O>ClC(Cl)Cl.O[Na].O>[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)-[c:11]1[cH:12][cH:13][n:14][c:15]2[c:16]([n:17][cH:18][n:19]21)[Cl:20]|EP2882710B1_0223
4.2.8|[C&H2&+0&D1:4]=[C&H1&+0&D2:3]-[C:2].[O&H1&+0&D1:1]-O>>[C&H2&+0&D2:4]1-[O&H0&+0&D2:1]-[C&H1&+0&D3:3]-1-[C:2]|[CH2:1]=[CH:2][CH2:3][P:4](=[O:5])([O:6][CH3:7])[O:8][CH3:9].O[OH:10]>CC(=O)C=C(C)[O-].CC(=O)C=C(C)[O-].CC(=O)C=C(C)[O-].CC(C)=O.[V+3]>[CH3:9][O:8][P:4](=[O:5])([CH2:3][CH:2]1[CH2:1][O:10]1)[O:6][CH3:7]|US10874679B2_0459
10.1.2|[Cl&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[Cl&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][s:12][c:13]1-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[O:20][CH3:21].O=C1CCC(N1[Cl:22])=O>CC(=O)O.ClCCl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][c:11]([s:12][c:13]1-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[O:20][CH3:21])[Cl:22]|EP3643713A1_0469
10.1.5|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][O:7][c:8]1[cH:9][c:10]2[CH2:11][C:12]([C:13]([c:14]2[c:15]([c:16]1[Cl:17])[Cl:18])=[O:19])([CH3:20])[CH:21]([CH3:22])[CH3:23].O=C1CCC(N1[Br:24])=O>O=C(OOC(=O)c1ccccc1)c1ccccc1.ClC(Cl)(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][O:7][c:8]1[cH:9][c:10]2[c:14]([C:13]([C:12]([CH:11]2[Br:24])([CH3:20])[CH:21]([CH3:22])[CH3:23])=[O:19])[c:15]([c:16]1[Cl:17])[Cl:18]|US10098878B2_0431
9.7.320|[C:4]-[C&H2&+0&D2:3]-[C&H1&+0&D3:2](-[C:1])-[#34]-c1:c:c:c:c:c:1>>[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]|[CH3:1][n:2]1[n:3][c:4]2[c:5]([CH2:6][CH2:7][C@H:8]3[N:9]([C:10]([CH:11]([CH2:12][C@:13]23[CH3:14])[Se]c2ccccc2)=[O:15])[CH3:16])[c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>>[CH3:16][N:9]1[C:10]([CH:11]=[CH:12][C@@:13]2([c:4]3[n:3][n:2]([c:17]([c:5]3[CH2:6][CH2:7][C@@H:8]12)-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH3:1])[CH3:14])=[O:15]|US06103910A
10.1.1|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[o:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)-[c:8]1[cH:9][cH:10][cH:11][o:12]1.O=C1CCC(N1[Br:13])=O>O=C(OOC(=O)c1ccccc1)c1ccccc1.ClC(Cl)(Cl)Cl>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)-[c:8]1[cH:9][cH:10][c:11]([o:12]1)[Br:13]|EP3188270A1_0144
10.1.5|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]-[C&H2&+0&D2:2]-[c:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[c:3])-[c:1]|[cH:1]1[cH:2][cH:3][c:4]2[CH2:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3-[c:12]2[cH:13]1.O=C1CCC(N1[Br:14])=O>O=C(OOC(=O)c1ccccc1)c1ccccc1.ClC(Cl)(Cl)Cl>[Br:14][CH:5]1[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2-[c:12]2[cH:13][cH:1][cH:2][cH:3][c:4]21|EP2895490B1_0347
1.8.12|[S&H1&+0&D1:5]-[c:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-Br>>[S&H0&+0&D2:5](-[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[SH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[Br:8].Br[CH:9]1[CH2:10][CH2:11]1>O.CS(C)=O.CC(C)(C)O[K]>[Br:8][c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[S:1][CH:9]1[CH2:10][CH2:11]1|US20080132479A1_0424
10.1.1|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[n:3]:[c&H1&+0&D2:2]:[s:1]>>[Br&H0&+0&D1:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[N-:1]=[N+:2]=[N:3][CH2:4][CH2:5][CH2:6][C:7]1([S:8][C:9](=[N:10][N:11]1[c:12]1[n:13][n:14][cH:15][s:16]1)[c:17]1[cH:18][c:19]([cH:20][cH:21][c:22]1[F:23])[F:24])[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1.O=C1CCC(N1[Br:31])=O>CC#N>[N-:1]=[N+:2]=[N:3][CH2:4][CH2:5][CH2:6][C:7]1([S:8][C:9](=[N:10][N:11]1[c:12]1[n:13][n:14][c:15]([s:16]1)[Br:31])[c:17]1[cH:18][c:19]([cH:20][cH:21][c:22]1[F:23])[F:24])[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1|EP3683222A1_3206
10.1.2|[Cl&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[o:1]>>[Cl&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)-[c:11]1[cH:12][o:13][cH:14][cH:15]1.O=C1CCC(N1[Cl:16])=O>CC(=O)O>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)-[c:11]1[cH:15][cH:14][o:13][c:12]1[Cl:16]|US20100227859A1_0564
10.1.2|[Cl&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[Cl&H0&+0&D1:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][CH2:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[C:14]12[CH2:15][CH:16]3[CH2:17][CH:18]([CH2:19][CH:20]([CH2:21]3)[CH2:22]1)[CH2:23]2.O=C1CCC(N1[Cl:24])=O>CN(C)C=O>[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][CH2:6][O:7][c:8]1[cH:13][cH:12][c:11]([cH:10][c:9]1[Cl:24])[C:14]12[CH2:15][CH:16]3[CH2:17][CH:18]([CH2:19][CH:20]([CH2:21]3)[CH2:22]1)[CH2:23]2|US10385040B2_0162
10.1.5|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1=[CH:11][CH2:12][CH2:13][C:14]1=[O:15].O=C1CCC(N1[Br:16])=O>ClC(Cl)(Cl)Cl>[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1=[CH:11][CH:12]([CH2:13][C:14]1=[O:15])[Br:16]|US04808578A
9.7.39|[N&H3&+0&D0:5].[c:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-Cl>>[N&H2&+0&D1:5]-[C&H0&+0&D4:3](-[c:4])(-[c:2])-[c:1]|[NH3:1].[CH3:2][N:3]1[C:4]([CH2:5][S:6][CH:7]([c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]21)[C:14](Cl)([c:15]1[cH:16][n:17][cH:18][n:19]1[CH3:20])[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[Cl:27])[c:28]1[cH:29][c:30]([cH:31][cH:32][cH:33]1)[Cl:34])=[O:35].CC(C)O>O.C1CCOC1>[CH3:2][N:3]1[C:4]([CH2:5][S:6][CH:7]([c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]21)[C:14]([NH2:1])([c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[Cl:27])[c:15]1[cH:16][n:17][cH:18][n:19]1[CH3:20])[c:28]1[cH:33][cH:32][cH:31][c:30]([cH:29]1)[Cl:34])=[O:35]|US20080027086A1_0172
6.5.10|[C&H3&D1:4]-[C&H0&+0&D4:3](-[C:2])(-[O&H0&+0&D2:1]-C)-O-C>>[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]|C[O:1][C:2]([CH3:3])(OC)[C:4]([CH3:5])([CH3:6])[O:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15]>O.Cc1ccccc1>[CH3:6][C:4]([CH3:5])([O:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15])[C:2]([CH3:3])=[O:1]|US08008298B2_0980
9.7.334|[c:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D3:1]:1-C-O-C>>[c:5]1:[n&H1&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D2:1]:1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[n:8][c:9]([n:10]([c:11]21)COC)[C:12]([F:13])([F:14])[F:15])[C:16]1=[N:17][NH:18][C:19]([C:20]1([CH3:21])[CH3:22])=[O:23]>C1CCOC1.[O-]C(=O)O.[Na+].Cl>[CH3:21][C:20]1([C:19]([NH:18][N:17]=[C:16]1[c:6]1[cH:5][cH:4][c:3]([c:11]2[n:10][c:9]([nH:8][c:7]12)[C:12]([F:13])([F:14])[F:15])[O:2][CH3:1])=[O:23])[CH3:22]|US07790724B2_0322
1.8.14|[C:5]-[S&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)F.[CH3:12][CH:13]([CH3:14])[S:15][Na]>CCOC(C)=O.CN(C)C=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:15][CH:13]([CH3:12])[CH3:14]|US08598164B2_0487
6.5.10|[C&H3&D1:4]-[C&H0&+0&D4:3](-[c:2])(-[O&H0&+0&D2:1]-C)-O-C>>[C&H3&D1:4]-[C&H0&+0&D3:3](-[c:2])=[O&H0&+0&D1:1]|C[O:1][C:2]([CH3:3])(OC)[c:4]1[cH:5][c:6]2[c:7]([cH:8][n:9][c:10]([c:11]2[o:12]1)[O:13][CH3:14])[C:15](=[O:16])[O:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[N+:24]([O-:25])=[O:26]>Cl.CCN=C=NCCCN(C)C.CN(C)c1ccncc1.COC(C)(OC)c1cc2c(cnc(c2o1)OC)C(=O)O.[O-][N+](=O)c1ccc(cc1)O.ClCCl>[CH3:14][O:13][c:10]1[n:9][cH:8][c:7]([c:6]2[c:11]1[o:12][c:4]([cH:5]2)[C:2]([CH3:3])=[O:1])[C:15](=[O:16])[O:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[N+:24]([O-:25])=[O:26]|US20100009977A1_0005
9.7.79|[#30&H0&+0&D0:4].[C:3]-[C&H2&+0&D2:2]-[I&H0&+0&D1:1]>>[#30&H0&+0&D2:4](-[I&H0&+0&D1:1])-[C&H2&+0&D2:2]-[C:3]|[F:1][C:2]([F:3])([CH2:4][CH2:5][I:6])[C:7]([F:8])([F:9])[F:10].[Zn:11]>C[Si](C)(C)Cl.C1CCOC1.BrCCBr.O.O>[F:8][C:7]([F:9])([F:10])[C:2]([F:3])([F:1])[CH2:4][CH2:5][Zn:11][I:6]|US09611267B2_0709
1.7.11|[C:5]-[O&H0&+0&D2:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][n:2]1[c:3]([c:4]([c:5]([n:6]([c:7]1=[O:8])-[c:9]1[cH:10][c:11]([c:12]([cH:13][c:14]1[F:15])[C:16]#[N:17])F)=[O:18])[Cl:19])[CH:20]([F:21])[F:22].[CH3:23][CH2:24][O:25][K]>F[K]>[CH3:23][CH2:24][O:25][c:11]1[cH:10][c:9]([c:14]([cH:13][c:12]1[C:16]#[N:17])[F:15])-[n:6]1[c:5]([c:4]([c:3]([n:2]([c:7]1=[O:8])[CH3:1])[CH:20]([F:21])[F:22])[Cl:19])=[O:18]|EP2508526A1_0233
1.3.5|[C:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-B(-O)-O>>[C:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[CH2:13][O:14][CH2:15][C@H:16]([C:17]#[N:18])[NH:19][C:20](=[O:21])[C@@H:22]([NH2:23])[CH2:24][c:25]1[cH:26][cH:27][cH:28][c:29]([cH:30]1)[CH3:31].OB(O)[c:32]1[cH:33][cH:34][c:35]([cH:36][cH:37]1)[F:38]>CC([O-])=O.CC([O-])=O.ClCCl.c1ccncc1.[Cu+2]>[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[CH2:13][O:14][CH2:15][C@H:16]([C:17]#[N:18])[NH:19][C:20](=[O:21])[C@H:22]([CH2:24][c:25]1[cH:26][cH:27][cH:28][c:29]([cH:30]1)[CH3:31])[NH:23][c:32]1[cH:33][cH:34][c:35]([cH:36][cH:37]1)[F:38]|US09849139B2_2426
1.7.11|[C:5]-[O&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1F)[C:10]([F:11])([F:12])[F:13].[O:14]([C:15]([2H:16])([2H:17])[2H:18])[Na]>>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[O:14][C:15]([2H:16])([2H:17])[2H:18])[C:10]([F:11])([F:12])[F:13]|US10556906B2_0181
1.7.11|[C:5]-[O&H0&+0&D2:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][K].[Cl:6][c:7]1[cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[c:15]([n:16]1)Cl>Cc1ccccc1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][c:15]1[n:16][c:7]([cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]12)[Cl:6]|EP3416957B1_0161
1.8.12|[c:5]:[c&H0&+0&D3:4](:[c:3])-Br.[c:2]-[S&H0&+0&D2:1]-[#19]>>[c:5]:[c&H0&+0&D3:4](:[c:3])-[S&H0&+0&D2:1]-[c:2]|[CH3:1][C@@H:2]1[O:3][CH2:4][C:5]2([C@@H:6]1[NH2:7])[CH2:8][CH2:9][N:10]([CH2:11][CH2:12]2)[c:13]1[n:14][cH:15][c:16]([c:17]2[c:18]1[cH:19][n:20][cH:21][n:22]2)Br.[NH2:23][c:24]1[n:25][cH:26][cH:27][c:28]([c:29]1[Cl:30])[S:31][K]>CC1(c2cccc(c2Oc2c1cccc2P(c1ccccc1)c1ccccc1)P(c1ccccc1)c1ccccc1)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)N(CC)C(C)C.N#N.[Pd].[Pd]>[CH3:1][C@@H:2]1[O:3][CH2:4][C:5]2([C@@H:6]1[NH2:7])[CH2:8][CH2:9][N:10]([CH2:11][CH2:12]2)[c:13]1[n:14][cH:15][c:16]([c:17]2[c:18]1[cH:19][n:20][cH:21][n:22]2)[S:31][c:28]1[cH:27][cH:26][n:25][c:24]([c:29]1[Cl:30])[NH2:23]|US20200017511A1_1498
1.7.11|[c:5]:[c&H0&+0&D3:4](:[n:3])-Cl.[c:2]-[O&H0&+0&D2:1]-[#11]>>[c:5]:[c&H0&+0&D3:4](:[n:3])-[O&H0&+0&D2:1]-[c:2]|[CH3:1][O:2][CH:3]([O:4][CH3:5])[CH:6]([C:7](=[O:8])[O:9][CH3:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[O:17][Na].[Cl:18][c:19]1[cH:20][c:21]([n:22][cH:23][n:24]1)Cl>C1CN2CCN1CC2>[CH3:10][O:9][C:7](=[O:8])[CH:6]([c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[O:17][c:21]1[cH:20][c:19]([n:24][cH:23][n:22]1)[Cl:18])[CH:3]([O:4][CH3:5])[O:2][CH3:1]|
9.7.220|[C:5]-[S&H0&+0&D2:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[N:1]#[C:2][S:3][K].[F:4][C:5]([F:6])([F:7])[c:8]1[n:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[c:16]([n:17]1)Cl>CC(=O)O>[N:1]#[C:2][S:3][c:16]1[n:17][c:8]([n:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]12)[C:5]([F:4])([F:6])[F:7]|EP1257555B1_0060
3.9.83|[C&H3&+0&D1:4]-[#3].[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][C:2]1=[CH:3][CH2:4][CH:5]([C:6]1([CH3:7])[CH3:8])[CH2:9][CH2:10][CH:11]([CH3:12])[CH:13]=[O:14].[CH3:15][Li]>O.CCOCC.O=S(=O)(O[Na])O[Na]>[CH3:1][C:2]1=[CH:3][CH2:4][CH:5]([C:6]1([CH3:7])[CH3:8])[CH2:9][CH2:10][CH:11]([CH3:12])[CH:13]([CH3:15])[OH:14]|EP1673352B1_0268
3.9.83|[C&H3&+0&D1:4]-[#3].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][CH2:2][O:3][CH:4]([O:5][CH2:6][CH3:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[CH:14]=[O:15].[CH3:16][Li]>O.CCOCC>[CH3:1][CH2:2][O:3][CH:4]([O:5][CH2:6][CH3:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[CH:14]([CH3:16])[OH:15]|EP3747863A1_0135
1.7.11|[C:5]-[O&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][Na].[N:10]#[C:11][c:12]1[cH:13][cH:14][n:15][c:16]([cH:17]1)Cl>CN(C)C=O>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][c:16]1[cH:17][c:12]([cH:13][cH:14][n:15]1)[C:11]#[N:10]|EP3191467B1_0200
1.8.12|[c:5]:[c&H0&+0&D3:4](:[n:3])-Br.[c:2]-[S&H0&+0&D2:1]-[#19]>>[c:5]:[c&H0&+0&D3:4](:[n:3])-[S&H0&+0&D2:1]-[c:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C:9]1([CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[c:15]1[n:16][cH:17][c:18]([n:19]2[c:20]1[cH:21][cH:22][n:23]2)Br)[CH3:24].[NH2:25][c:26]1[n:27][cH:28][cH:29][c:30]([c:31]1[Cl:32])[S:33][K]>CC1(c2cccc(c2Oc2c1cccc2P(c1ccccc1)c1ccccc1)P(c1ccccc1)c1ccccc1)C.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.O=C(C=Cc1ccccc1)C=Cc1ccccc1.CC(C)N(CC)C(C)C.C1COCCO1.[Pd].[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C:9]1([CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[c:15]1[n:16][cH:17][c:18]([n:19]2[c:20]1[cH:21][cH:22][n:23]2)[S:33][c:30]1[cH:29][cH:28][n:27][c:26]([c:31]1[Cl:32])[NH2:25])[CH3:24]|US20200339552A1_0881
3.9.64|[C&H2&+0&D1:5]=[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[N&+]#N>>[C&H1&+0&D2:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[N+]#N.[CH2:8]=[CH:9][CH2:10][C:11]#[N:12].F[B-](F)(F)F>CC(=O)O[Pd]OC(C)=O.Cc1ccc(cc1)N.F[B-](F)(F)F.O=NO[Na].CCO.O.[H+]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH:8]=[CH:9][CH2:10][C:11]#[N:12]|US09238660B1_0097
8.8.5|[O&H0&-&D1:4]-[Cl&+]-[O&-].[O&H0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[O&H1&+0&D1:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][n:2]1[c:3]([c:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21)[CH:11]=[O:12])[Br:13].[O-:14][Cl]=O>O=P(O)(O)O[Na].C1COCCO1.CC=C(C)C.[O-]P([O-])([O-])=O.CC(C)O.O=[Cl]O[Na].O.O>[CH3:1][n:2]1[c:3]([c:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21)[C:11](=[O:12])[OH:14])[Br:13]|US20200190020A1_0218
4.2.35|[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[C&H2&+0&D2:1]-Br>>[O&H0&+0&D2:4]1-[C&H2&+0&D2:1]-[C&H1&+0&D3:3]-1-[c:2]|[CH3:1][S:2](=[O:3])(=[O:4])[N:5]([CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[C:19](=[O:20])[CH2:21]Br>[Na+].CCO.[BH4-]>[CH3:1][S:2](=[O:3])(=[O:4])[N:5]([CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[CH:19]1[CH2:21][O:20]1|US08673920B2_0200
4.2.35|[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:4]1-[C&H2&+0&D2:1]-[C&H1&+0&D3:3]-1-[c:2]|[O:1]=[C:2]([CH2:3]Cl)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[F:10]>CB1OC([C@@H]2CCCN12)(c1ccccc1)c1ccccc1.O[Na].C1CCOC1>[F:10][c:7]1[cH:6][cH:5][c:4]([cH:9][cH:8]1)[CH:2]1[CH2:3][O:1]1|US20200010446A1_0384
1.3.5|[N&H2&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-B(-O)-O>>[N&H1&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[S:4])[c:5]1[cH:6][c:7]([c:8]([s:9]1)[CH3:10])[NH2:11].OB(O)[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>COC(=O)c1cc(c(s1)SC)Nc1ccc(cc1)-c1ccccc1>[CH3:1][O:2][C:3](=[S:4])[c:5]1[cH:6][c:7]([c:8]([s:9]1)[CH3:10])[NH:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US07332521B2_0124
1.7.1|[O&H1&+0&D1:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-B(-O)-O>>[O&H0&+0&D2:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[OH:9])[O:10][c:11]1[c:12]([cH:13][c:14]([cH:15][c:16]1[CH3:17])[N+:18]([O-:19])=[O:20])[CH3:21].OB(O)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>CCOC(C)=O.CC([O-])=O.CC([O-])=O.ClCCl.[Cu+2]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[O:9][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[O:10][c:11]1[c:12]([cH:13][c:14]([cH:15][c:16]1[CH3:17])[N+:18]([O-:19])=[O:20])[CH3:21]|US20080249091A1_0356
8.8.5|[C:4]-[C&H1&+0&D2:3]=[O&H0&D1:2].[O&H0&-&D1:1]-[Cl&+]-[O&-]>>[C:4]-[C&H0&+0&D3:3](-[O&H1&+0&D1:1])=[O&H0&D1:2]|[Na+].[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][C:8]([CH:9]=[O:10])=[C:11]([Cl:12])[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[O-:25][Cl]=O>O.CC(C)(C)O.O=P(O)(O)O[Na]>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][C:8]([C:9](=[O:10])[OH:25])=[C:11]([Cl:12])[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|EP3514138A1_0201
3.5.3|[C:5]-[C&H2&+0&D2:4]-[#30&+].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)I.[CH3:14][O:15][C:16](=[O:17])[CH2:18][CH2:19][CH2:20][Zn+].[I-]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1CCOC1>[CH3:14][O:15][C:16](=[O:17])[CH2:18][CH2:19][CH2:20][c:12]1[cH:11][cH:10][cH:9][c:8]([cH:13]1)[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20100160369A1_0727
3.5.3|[c:5]:[c&H0&+0&D3:4](:[c:3])-I.[c:2]-[C&H2&+0&D2:1]-[#30&+]>>[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H2&+0&D2:1]-[c:2]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)I.[Cl:10][c:11]1[cH:12][cH:13][cH:14][c:15]([c:16]1[Cl:17])[CH2:18][Zn+].[Cl-]>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.c1ccc(o1)P(c1ccco1)c1ccco1.C1CCOC1.[NH4+].[Cl-].[Pd]>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:18][c:15]1[cH:14][cH:13][cH:12][c:11]([c:16]1[Cl:17])[Cl:10]|US20160002248A1_0345
9.7.70|[C:5]-[C&H0&+0&D4:4](-[C:3])(-[c:2])-C(-[N&H2&+0&D1:1])=O>>[C:5]-[C&H0&+0&D4:4](-[C:3])(-[N&H2&+0&D1:1])-[c:2]|[CH3:1][CH2:2][C:3]([CH2:4][CH3:5])(C([NH2:6])=O)[c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O=C(O[I](OC(=O)C(F)(F)F)c1ccccc1)C(F)(F)F.CC#N.O>[CH3:1][CH2:2][C:3]([NH2:6])([CH2:4][CH3:5])[c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|EP3169666B1_0166
3.5.3|[C:5]-[C&H2&+0&D2:4]-[#30&+].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([c:10]([cH:11]1)[C:12]#[N:13])Cl.[CH3:14][CH:15]([CH3:16])[CH2:17][Zn+].[Br-]>CC(C)(C)[P](C(C)(C)C)(C(C)(C)C)[Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C.CN1CCCC1=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([c:10]([cH:11]1)[C:12]#[N:13])[CH2:17][CH:15]([CH3:14])[CH3:16]|US20190389899A1_0989
3.5.3|[c:5]:[c&H0&+0&D3:4](:[n:3])-Br.[c:2]-[C&H2&+0&D2:1]-[#30&+]>>[c:5]:[c&H0&+0&D3:4](:[n:3])-[C&H2&+0&D2:1]-[c:2]|[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[CH2:8][Zn+])[F:9].[Br:10][c:11]1[cH:12][n:13][c:14]([cH:15][cH:16]1)Br.[Br-]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1CCOC1>[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[CH2:8][c:14]1[cH:15][cH:16][c:11]([cH:12][n:13]1)[Br:10])[F:9]|EP2344494B1_0469
3.5.3|[c:5]:[c&H0&+0&D3:4](:[c:3])-Cl.[c:2]-[C&H2&+0&D2:1]-[#30&+]>>[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2](=[O:3])[N:4]1[CH2:5][C:6]2([CH2:7]1)[CH2:8][N:9]([c:10]1[cH:11][c:12]([cH:13][cH:14][c:15]12)Cl)[C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22].[cH:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[CH2:29][Zn+].[Br-]>CC(C)n1ccn(c1=[Pd-3](Cl)(Cl)c1ncccc1Cl)C(C)C.CN1CCCC1=O.Br[Li]>[CH3:1][C:2](=[O:3])[N:4]1[CH2:5][C:6]2([CH2:7]1)[CH2:8][N:9]([c:10]1[cH:11][c:12]([cH:13][cH:14][c:15]12)[CH2:29][c:26]1[cH:27][cH:28][cH:23][cH:24][cH:25]1)[C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22]|US20190343812A1_0650
3.5.3|[C:5]-[C&H2&+0&D2:4]-[#30&+].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|Br[c:1]1[cH:2][cH:3][cH:4][cH:5][n:6]1.[CH3:7][C:8]([CH3:9])([CH3:10])[CH2:11][Zn+].[Cl-]>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.ClCCl.Cl[Pd]Cl.[NH4+].[Cl-].[Fe+2]>[CH3:7][C:8]([CH3:9])([CH3:10])[CH2:11][c:1]1[cH:2][cH:3][cH:4][cH:5][n:6]1|US08785445B2_0792
3.9.60|[C:5]-[C&H2&+0&D2:4]-[#30&+].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[OH:1][CH2:2][c:3]1[cH:4][cH:5][c:6]2[n:7][c:8]([o:9][c:10]2[cH:11]1)-[c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21])Cl.[CH3:22][CH:23]([CH3:24])[CH2:25][Zn+].[Br-]>C1CCOC1.Cl>[CH3:22][CH:23]([CH3:24])[CH2:25][c:15]1[cH:14][cH:13][c:12]([cH:17][c:16]1[C:18]([F:19])([F:20])[F:21])-[c:8]1[n:7][c:6]2[cH:5][cH:4][c:3]([cH:11][c:10]2[o:9]1)[CH2:2][OH:1]|US08580841B2_0512
3.5.3|[c:5]:[c&H0&+0&D3:4](:[n:3])-Cl.[c:2]-[C&H2&+0&D2:1]-[#30&+]>>[c:5]:[c&H0&+0&D3:4](:[n:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][n:9][c:10]1Cl)[Cl:11].[F:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[CH2:19][Zn+].[Cl-]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1CCOC1.O>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][n:9][c:10]1[CH2:19][c:16]1[cH:15][cH:14][c:13]([cH:18][cH:17]1)[F:12])[Cl:11]|US20140155389A1_0676
3.5.3|[C:5]-[C&H2&+0&D2:4]-[#30&+].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][S:2](=[O:3])(=[O:4])[NH:5][c:6]1[cH:7][cH:8][c:9]2-[c:10]3[c:11]([cH:12][cH:13][cH:14][c:15]3[O:16][CH:17]([c:18]2[cH:19]1)[c:20]1[cH:21][cH:22][cH:23][c:24]([cH:25]1)Br)[O:26][CH:27]([F:28])[F:29].[CH3:30][CH2:31][O:32][C:33](=[O:34])[CH2:35][CH2:36][Zn+].[Br-]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.C1CCOC1.O.[Pd]>[CH3:30][CH2:31][O:32][C:33](=[O:34])[CH2:35][CH2:36][c:24]1[cH:23][cH:22][cH:21][c:20]([cH:25]1)[CH:17]1[O:16][c:15]2[cH:14][cH:13][cH:12][c:11]([c:10]2-[c:9]2[c:18]1[cH:19][c:6]([cH:7][cH:8]2)[NH:5][S:2]([CH3:1])(=[O:3])=[O:4])[O:26][CH:27]([F:28])[F:29]|US07109339B2_0830
3.5.3|[c:5]:[c&H0&+0&D3:4](:[c:3])-Br.[c:2]-[C&H2&+0&D2:1]-[#30&+]>>[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[C:11](=[O:12])[O:13][CH3:14])Br.[F:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[CH2:22][Zn+].[Br-]>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.C1CCOC1.Cl.[Pd]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[C:11](=[O:12])[O:13][CH3:14])[CH2:22][c:19]1[cH:20][cH:21][c:16]([cH:17][cH:18]1)[F:15]|US09334263B2_0287
3.5.2|[C:5]-[C&H2&+0&D2:4]-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][Mg]Br.Br[c:13]1[cH:14][cH:15][s:16][cH:17]1>[NH4+].[Cl-].CCOCC>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][c:13]1[cH:14][cH:15][s:16][cH:17]1|EP3371291B1_0036
2.1.18|[C:5]-[N&H1&+0&D2:4]-[C:3].[O&H0&D1:2]=[C&H1&+0&D2:1]-O>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H1&+0&D2:1]=[O&H0&D1:2]|[CH3:1][CH:2]([NH:3][CH2:4][C:5]#[N:6])[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.[O:13]=[CH:14]O>O.Cc1cccc(c1)C>[CH3:1][CH:2]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[N:3]([CH:14]=[O:13])[CH2:4][C:5]#[N:6]|US08389526B2_0332
9.7.73|[C:5]-[C&H1&+0&D3:4](-[C:3])-O.[N&+:2]=[N&H0&+0&D2:1]-[#11]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][CH2:2][CH:3](O)[CH2:4][CH2:5][c:6]1[c:7]([cH:8][cH:9][cH:10][c:11]1[Br:12])[Br:13].[N-:14]=[N+:15]=[N:16][Na]>CN(C)C=O.CS(=O)(=O)Cl.ClCCl>[CH3:1][CH2:2][CH:3]([CH2:4][CH2:5][c:6]1[c:7]([cH:8][cH:9][cH:10][c:11]1[Br:12])[Br:13])[N:16]=[N+:15]=[N-:14]|US10472364B2_0674
3.11.2|[C&H3&D1:5]-[C&H2&+0&D2:4]-[C:3].[C:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])[CH2:4][CH3:5].O=[CH:6][CH:7]1[CH2:8][CH:9]2[CH:10]=[CH:11][CH:12]1[CH2:13]2>O.Cc1ccc(cc1)S(=O)(=O)O.O[Na]>[CH3:5][C:4](=[CH:6][CH:7]1[CH2:8][CH:9]2[CH:10]=[CH:11][CH:12]1[CH2:13]2)[C:2]([CH3:1])=[O:3]|EP0010347B1_0147
1.6.8|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[C:3]-[N&H1&+0&D2:2]-[S:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[S:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]1[NH:6][S:7]([c:8]2[c:9]([cH:10][cH:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]32)[C:18]=1[OH:19])(=[O:20])=[O:21].[CH3:22][CH2:23]I>CCO.O[Na]>[CH3:22][CH2:23][N:6]1[C:5](=[C:18]([c:9]2[cH:10][cH:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[c:8]2[S:7]1(=[O:20])=[O:21])[OH:19])[C:3](=[O:4])[O:2][CH3:1]|EP3653618A1_0367
1.2.1|[C&H3&D1:5]-[C&H1&+0&D2:4]=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]=O.[CH3:3][CH2:4][NH:5][CH:6]1[CH2:7][CH2:8][CH2:9][N:10]([CH2:11]1)[CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>CCN.O=C1CCCN(C1)Cc1ccccc1>[CH3:1][CH2:2][N:5]([CH2:4][CH3:3])[CH:6]1[CH2:7][CH2:8][CH2:9][N:10]([CH2:11]1)[CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|EP3286193B1_0090
7.3.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=[N&H0&+0&D2:2]-[S:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-[N&H1&+0&D2:2]-[S:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[S:5](=[O:6])[N:7]=[C:8]([CH3:9])[c:10]1[cH:11][c:12]([c:13]([c:14]([cH:15]1)[F:16])[NH:17][S:18]([CH3:19])(=[O:20])=[O:21])[F:22]>C1CCOC1.CO.[Na+].[BH4-]>[CH3:19][S:18](=[O:20])(=[O:21])[NH:17][c:13]1[c:14]([cH:15][c:10]([cH:11][c:12]1[F:22])[CH:8]([CH3:9])[NH:7][S:5](=[O:6])[C:2]([CH3:1])([CH3:3])[CH3:4])[F:16]|US10752626B2_0327
8.4.2|[C:4]-[N&H0&+0&D2:3]=[C:2].[O&H1&+0&D1:1]-O-C(=O)-c1:c:c:c:c(-Cl):c:1>>[C:4]-[N&H0&+&D3:3](=[C:2])-[O&H0&-&D1:1]|[CH2:1]=[CH:2][CH2:3][N:4]1[C:5]([CH2:6][N:7]=[C:8]([c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]21)[Cl:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22])=[O:23].O=C(O[OH:24])c1cccc(c1)Cl>ClC(Cl)Cl>[CH2:1]=[CH:2][CH2:3][N:4]1[C:5]([CH2:6][N+:7](=[C:8]([c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]21)[Cl:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22])[O-:24])=[O:23]|EP0491441A1_0055
9.7.2|[N&+:5]=[N&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-N>>[N&+:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[N-:1]=[N+:2]=[N:3][Na].N[c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[C:10](=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[Cl:18]>O.O.O.O.[Na+].Cl.CC([O-])=O.CC(=O)O.O=NO[Na]>[N-:1]=[N+:2]=[N:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[C:10](=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[Cl:18]|US20180339977A1_0356
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[F&H0&D1:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[F&H0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH:7]2[C:8]([C:9](=[CH:10][CH:11]12)[F:12])=[O:13]>CCO.[Pd]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH:7]2[C:8]([CH:9]([CH2:10][CH:11]12)[F:12])=[O:13]|US20130116445A1_0074
1.2.9|[C&H3&D1:5]-[C&H2&+0&D2:4]-O.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[ClH:1].[CH3:2][CH2:3]O.[CH3:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[OH:11])[NH:12][CH2:13][CH3:14]>CCBr>[ClH:1].[CH3:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[OH:11])[N:12]([CH2:3][CH3:2])[CH2:13][CH3:14]|US06900244B2_0116
7.3.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=[N&H0&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[N:8]=[C:9]([CH3:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[NH:8][CH:9]([CH3:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US08541522B2_0250
7.3.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=[N&H0&+0&D2:2]-[N:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-[N&H1&+0&D2:2]-[N:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][N:9]=[C:10]([CH3:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[C:18](=[O:19])[O:20][CH2:21][CH3:22]>Cc1ccc(cc1)S(=O)(=O)O.CCOC(C)=O.C1CCOC1.N#C[BH3-].ClCCl.O.[Na+].[Na+].[OH-]>[CH3:22][CH2:21][O:20][C:18](=[O:19])[c:15]1[cH:14][cH:13][c:12]([cH:17][cH:16]1)[CH:10]([CH3:11])[NH:9][NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20200317659A1_0653
7.6.1|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:2]-[c:1]|[CH3:1][C:2](=[CH:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[F:10])[C:11](=[O:12])[OH:13]>CO.[H][H].[O-2].[Pt+2]>[CH3:1][CH:2]([CH2:3][c:4]1[cH:9][c:8]([cH:7][cH:6][cH:5]1)[F:10])[C:11](=[O:12])[OH:13]|US05430191A
1.2.9|[C&H3&D1:5]-[C&H2&+0&D2:4]-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[O:1]=[S:2](=[O:3])([c:4]1[cH:5][cH:6][cH:7][c:8]2[cH:9][n:10][cH:11][cH:12][c:13]21)[N:14]1[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]1.[CH3:20][CH2:21]O>O=C(O[K])O[K].ClC(Cl)Cl.ClC(Cl)Cl.CCBr.CO>[CH3:20][CH2:21][N:17]1[CH2:18][CH2:19][N:14]([CH2:15][CH2:16]1)[S:2](=[O:1])(=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]2[cH:9][n:10][cH:11][cH:12][c:13]21|US04009166A
3.11.2|[C&H3&D1:5]-[C&H1&+0&D2:4]=O.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]=O.[CH3:3][O:4][C@H:5]1[CH2:6][CH2:7][C@H:8]2[C@@H:9]3[CH2:10][CH2:11][C@H:12]4[CH2:13][C:14]([CH2:15][CH2:16][C@@:17]4([C@H:18]3[CH2:19][CH2:20][C@:21]12[CH3:22])[CH3:23])=[O:24]>CCO.CC(=O)O.O[K]>[CH3:3][O:4][C@H:5]1[CH2:6][CH2:7][C@H:8]2[C@@H:9]3[CH2:10][CH2:11][C@H:12]4[CH2:13][C:14]([C:15]([CH2:16][C@@:17]4([C@H:18]3[CH2:19][CH2:20][C@:21]12[CH3:22])[CH3:23])=[CH:2][CH3:1])=[O:24]|US20090111860A1_0275
1.6.8|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2]I.[CH3:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][c:9]([cH:10][c:11]([cH:12]1)[N+:13]([O-:14])=[O:15])[N+:16]([O-:17])=[O:18]>O.CN(C)C=O.[NaH]>[CH3:1][CH2:2][N:6]([C:4]([CH3:3])=[O:5])[c:7]1[cH:12][c:11]([cH:10][c:9]([cH:8]1)[N+:16]([O-:17])=[O:18])[N+:13]([O-:14])=[O:15]|EP3555063B1_0229
3.9.60|[C:5]-[C&H2&+0&D2:4]-[#30]-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][Zn]Cl.[O:6]=[C:7]1[CH2:8][CH2:9][N:10]([c:11]2[cH:12][cH:13][c:14]([cH:15][c:16]12)Br)[C:17](=[O:18])[O:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>>[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][c:14]1[cH:13][cH:12][c:11]2[c:16]([cH:15]1)[C:7]([CH2:8][CH2:9][N:10]2[C:17](=[O:18])[O:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)=[O:6]|US09056859B2_0266
3.7.2|[C&H3&+0&D1:4]-[#12&+].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[Br-].[CH3:1][Mg+].[O:2]=[CH:3][c:4]1[cH:5][c:6]([cH:7][c:8]([c:9]1[F:10])[Br:11])[F:12]>CCOCC.C1CCOC1>[CH3:1][CH:3]([OH:2])[c:4]1[cH:5][c:6]([cH:7][c:8]([c:9]1[F:10])[Br:11])[F:12]|US20200172512A1_0658
1.6.8|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[c:2]1[nH:3][c:4]([c:5]2[cH:6][cH:7][cH:8][c:9]3[S:10][c:11]4[cH:12][cH:13][c:14]([cH:15][c:16]4-[n:17]1[c:18]32)[C:19]([F:20])([F:21])[F:22])=[O:23].[CH3:24][CH2:25]I>CN(C)C=O.[NaH]>[CH3:24][CH2:25][n:3]1[c:4]([c:5]2[cH:6][cH:7][cH:8][c:9]3[S:10][c:11]4[cH:12][cH:13][c:14]([cH:15][c:16]4-[n:17]([c:18]32)[c:2]1=[O:1])[C:19]([F:20])([F:21])[F:22])=[O:23]|EP3204360B1_0195
7.6.1|[C&H3&D1:5]-[C&H0&+0&D3:4](-[N:3])=[C&H1&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[N:3])-[C&H2&+0&D2:2]-[C:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[NH:11][C:12]([CH3:13])=[CH:14][C:15](=[O:16])[O:17][CH2:18][CH3:19]>CC(=O)O.ClC(Cl)Cl.[O-2].[Pt+2]>[CH3:19][CH2:18][O:17][C:15](=[O:16])[CH2:14][CH:12]([CH3:13])[NH:11][c:5]1[cH:6][cH:7][c:8]([c:3]([cH:4]1)[O:2][CH3:1])[O:9][CH3:10]|US20090299089A1_0105
3.5.3|[C:5]-[C&H2&+0&D2:4]-[#30]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[C:2]1[O:3][CH2:4][C:5]([N:6]1[CH2:7][CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[c:15]1[cH:16][cH:17][cH:18][c:19]([n:20]1)Br)=[O:21].[CH3:22][CH:23]([CH3:24])[CH2:25][Zn]Br>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCOC(C)=O.C1CCOC1.O>[CH3:22][CH:23]([CH3:24])[CH2:25][c:19]1[cH:18][cH:17][cH:16][c:15]([n:20]1)[N:12]1[CH2:13][CH2:14][CH:9]([CH2:10][CH2:11]1)[CH2:8][CH2:7][N:6]1[C:5]([CH2:4][O:3][C:2]1=[O:1])=[O:21]|US20120101134A1_0236
3.7.5|[C&H3&+0&D1:4]-[#12]-I.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][C:10]([F:11])([F:12])[F:13].[CH3:14][Mg]I>CCOCC.[NH4+].O.[Cl-]>[CH3:14][CH:2]([OH:1])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][C:10]([F:11])([F:12])[F:13]|US20200157070A1_1001
10.4.15|[O&H0&D1:5]=[N&H0&+0&D2:4]-O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&D1:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[N:2]O.[OH:3][c:4]1[cH:5][cH:6][cH:7][c:8]2[cH:9][cH:10][n:11][cH:12][c:13]12>>[O:1]=[N:2][c:7]1[cH:6][cH:5][c:4]([c:13]2[cH:12][n:11][cH:10][cH:9][c:8]12)[OH:3]|US20200354357A1_0415
7.6.1|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-[C&H2&+0&D2:2]-[C:1]|[CH3:1][C:2](=[CH:3][CH2:4][C:5](=[O:6])[OH:7])[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>>[CH3:1][CH:2]([CH2:3][CH2:4][C:5](=[O:6])[OH:7])[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US08506655B1_0122
1.2.1|[C&H3&D1:5]-[N&H1&+0&D2:4]-[c:3].[C:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][c:9]1[c:10]([c:11]2[cH:12][c:13]([cH:14][cH:15][c:16]2[n:17]1[CH:18]([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[Cl:31])[CH2:32][CH:33]=O)([c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)[c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1.[CH3:46][O:47][C:48](=[O:49])[c:50]1[cH:51][cH:52][c:53]([cH:54][cH:55]1)[NH:56][CH3:57]>>[CH3:46][O:47][C:48](=[O:49])[c:50]1[cH:51][cH:52][c:53]([cH:54][cH:55]1)[N:56]([CH3:57])[CH2:33][CH2:32][c:10]1[c:9]([n:17]([c:16]2[c:11]1[cH:12][c:13]([cH:14][cH:15]2)[Cl:31])[CH:18]([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[CH2:8][CH2:7][O:6][Si:5]([c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)([c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1)[C:2]([CH3:1])([CH3:3])[CH3:4]|US20100120669A1_0541
1.2.1|[C&H3&D1:5]-[C&H1&+0&D2:4]=O.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[NH:12][c:13]1[cH:14][c:15]2[C:16](=[CH:17][CH2:18][C:19]([c:20]2[cH:21][c:22]1[CH3:23])([CH3:24])[CH3:25])[CH2:26][CH3:27].[CH3:28][CH:29]=O>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N:12]([CH2:29][CH3:28])[c:13]1[cH:14][c:15]2[C:16](=[CH:17][CH2:18][C:19]([c:20]2[cH:21][c:22]1[CH3:23])([CH3:24])[CH3:25])[CH2:26][CH3:27]|US08399452B2_0854
3.7.5|[C&H3&+0&D1:4]-[#12]-I.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]([CH:6]=[O:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[Cl:14])[Cl:15].[CH3:16][Mg]I>O.Cl.CCOCC>[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]([c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[Cl:14])[Cl:15])[CH:6]([CH3:16])[OH:7]|EP0211598A2_0089
1.2.9|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[CH2:9]O)[NH2:10].[CH3:11][NH:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1>O=S(Cl)Cl.ClCCl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[CH2:9][N:12]([CH3:11])[CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[NH2:10]|EP1121372B1_0440
3.7.2|[C&H3&+0&D1:4]-[#12&+].[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[N:8]1[C:9]([CH2:10][CH:11]1[CH2:12][CH:13]=[O:14])=[O:15].[CH3:16][Mg+].[Br-]>O=S1(O[Mg]O1)=O.CCOCC>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[N:8]1[C:9]([CH2:10][CH:11]1[CH2:12][CH:13]([CH3:16])[OH:14])=[O:15]|US10160762B2_0370
3.11.91|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]1([O:3][CH2:4][CH2:5][CH:6]2[CH2:7][C:8]([N:9]21)=[O:10])[CH3:11].[CH3:12][CH2:13]I>CC1(OCCC2C(C(N21)=O)C(C)C)C>[CH3:12][CH2:13][CH:7]1[C:8]([N:9]2[CH:6]1[CH2:5][CH2:4][O:3][C:2]2([CH3:1])[CH3:11])=[O:10]|US20200369669A1_0533
3.9.60|[C:5]-[C&H2&+0&D2:4]-[#30]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][Zn]Br.[NH2:5][C:6](=[O:7])[c:8]1[cH:9][c:10]([cH:11][cH:12][c:13]1[OH:14])Br>C1CCOC1>[CH3:1][CH:2]([CH3:3])[CH2:4][c:10]1[cH:11][cH:12][c:13]([c:8]([cH:9]1)[C:6]([NH2:5])=[O:7])[OH:14]|US20190119241A1_2092
7.3.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[C:1]|[CH3:1][CH:2]([CH3:3])[N:4]=[C:5]([CH3:6])[CH2:7][C:8]1=[C:9]2[c:10]3[cH:11][cH:12][c:13]([cH:14][c:15]3[CH2:16][CH2:17][CH:18]2[CH2:19][CH2:20][NH:21][C:22]1=[O:23])[O:24][CH3:25]>CCO.[O-2].[O-2].[Pt+4]>[CH3:25][O:24][c:13]1[cH:12][cH:11][c:10]2[C:9]3=[C:8]([C:22]([NH:21][CH2:20][CH2:19][CH:18]3[CH2:17][CH2:16][c:15]2[cH:14]1)=[O:23])[CH2:7][CH:5]([CH3:6])[NH:4][CH:2]([CH3:1])[CH3:3]|EP1758976B1_0033
7.6.1|[C&H3&D1:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][CH2:2][C:3](=[CH:4][CH3:5])[CH:6]1[NH:7][C:8]([CH2:9][CH:10]([C:11]11[C:12]([NH:13][c:14]2[cH:15][c:16]([cH:17][cH:18][c:19]21)[Cl:20])=[O:21])[c:22]1[cH:23][c:24]([cH:25][cH:26][cH:27]1)[Cl:28])=[O:29]>CCOC(C)=O.[O-2].[Pt+2]>[CH3:1][CH2:2][CH:3]([CH2:4][CH3:5])[CH:6]1[NH:7][C:8]([CH2:9][CH:10]([C:11]11[C:12]([NH:13][c:14]2[cH:15][c:16]([cH:17][cH:18][c:19]21)[Cl:20])=[O:21])[c:22]1[cH:27][cH:26][cH:25][c:24]([cH:23]1)[Cl:28])=[O:29]|EP3287467A1_0091
3.5.3|[C:5]-[C&H2&+0&D2:4]-[#30]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Cl:1][c:2]1[cH:3][n:4]2[n:5][c:6]([cH:7][cH:8][c:9]2[n:10]1)Cl.[CH3:11][CH2:12][CH2:13][Zn]Br>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccccc1>[CH3:11][CH2:12][CH2:13][c:6]1[cH:7][cH:8][c:9]2[n:10][c:2]([cH:3][n:4]2[n:5]1)[Cl:1]|US09782408B2_2377
1.6.8|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18]([CH3:19])=[O:20].[CH3:21][CH2:22]I>[Na+].C[O-].CN(C)C=O>[CH3:21][CH2:22][N:11]([c:12]1[cH:17][c:16]([cH:15][cH:14][cH:13]1)[C:18]([CH3:19])=[O:20])[S:8](=[O:9])(=[O:10])[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH3:1]|US20200360357A1_0566
7.6.1|[C&H3&D1:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[N:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[N:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][CH3:8])[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[C:21]([F:22])([F:23])[F:24]>CCO.[Ni]>[CH3:8][CH2:7][CH:6]([C:4](=[O:5])[O:3][CH2:2][CH3:1])[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[C:21]([F:22])([F:23])[F:24]|US07122682B2_0266
3.9.24|[C:5]-[C&H2&+0&D2:4]-[#12]-Cl.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][n:4]2[n:5][c:6]([cH:7][cH:8][c:9]2[n:10]1)Cl.[CH3:11][CH2:12][CH2:13][Mg]Cl>Cl[Ni]1([P](CCC[P]1(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1)Cl.C1CCOC1>[CH3:11][CH2:12][CH2:13][c:6]1[cH:7][cH:8][c:9]2[n:10][c:2]([cH:3][n:4]2[n:5]1)[CH3:1]|US20160031866A1_0111
1.6.8|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[C:3]-[N&H1&+0&D2:2]-[N:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[N:1]|[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10]([F:11])([F:12])[F:13])[N:14]1[CH2:15][CH:16]([CH:17]([NH:18]1)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25])[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1.[CH3:32][CH2:33]I>CCN(C(C)C)C(C)C.CN(C)C=O>[CH3:32][CH2:33][N:18]1[CH:17]([CH:16]([CH2:15][N:14]1[C:2](=[O:1])[NH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10]([F:11])([F:12])[F:13])[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25]|US20190106427A1_0290
3.11.91|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][c:9]2[c:10]([cH:11][cH:12][c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3[c:19]2=[O:20])[cH:21]1.[CH3:22][CH2:23]I>CN(C)P(=O)(N(C)C)N(C)C.CC(C)NC(C)C.CCCCCC.CCOCC.CCCC[Li].C1CCOC1.CO.O>[CH3:22][CH2:23][CH:5]([C:3](=[O:4])[O:2][CH3:1])[c:6]1[cH:7][cH:8][c:9]2[c:19]([c:18]3[cH:17][cH:16][cH:15][cH:14][c:13]3[cH:12][cH:11][c:10]2[cH:21]1)=[O:20]|US20190031599A1_0533
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[O&H1&D1:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[O&H1&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][CH2:9][CH:10]1[CH2:11][C:12](=[CH:13][C:14]([O:15]1)=[O:16])[OH:17]>CCO>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][CH2:9][CH:10]1[CH2:11][CH:12]([CH2:13][C:14]([O:15]1)=[O:16])[OH:17]|US07649001B2_0645
3.5.2|[C:5]-[C&H2&+0&D2:4]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Br>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH2:1]=[C:2]([Br:3])[CH2:4]Br.Br[Mg][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1>O.Cl.CC(C)=O.CCOCC.O=C=O.Brc1ccccc1.[Mg]>[CH2:1]=[C:2]([Br:3])[CH2:4][c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1|US09643946B2_1864
7.6.1|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:2]-[C:1]|[CH3:1][C:2](=[CH:3][CH:4]=[O:5])[CH2:6][CH2:7][CH:8]=[C:9]([CH3:10])[CH3:11]>>[CH3:10][C:9]([CH3:11])=[CH:8][CH2:7][CH2:6][CH:2]([CH3:1])[CH2:3][CH:4]=[O:5]|US08946481B2_0209
1.6.8|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2]I.[O:3]=[C:4]1[NH:5][CH2:6][CH:7]2[CH2:8][CH2:9][CH2:10][CH:11]12>O.Cc1ccccc1C.[NaH]>[CH3:1][CH2:2][N:5]1[CH2:6][CH:7]2[CH2:8][CH2:9][CH2:10][CH:11]2[C:4]1=[O:3]|EP3394061B1_0338
1.6.8|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-I>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C@@H:9]1[S:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[N:17]([C:18]([C@@H:19]1[OH:20])=[O:21])[CH2:22][CH2:23][NH:24][CH3:25].[CH3:26][CH2:27][CH2:28]I>O.O.CN(C)C=O.O=C(O[K])O[K]>[CH3:26][CH2:27][CH2:28][N:24]([CH3:25])[CH2:23][CH2:22][N:17]1[C:18]([C@@H:19]([C@@H:9]([S:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21)[c:6]1[cH:7][cH:8][c:3]([cH:4][cH:5]1)[O:2][CH3:1])[OH:20])=[O:21]|US20200044154A1_0193
7.6.1|[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[N&H2&D1:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[N&H2&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]=[C:7]([NH2:8])[C:9]1([CH2:10][CH2:11][CH2:12]1)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19]>[NH4+].[Na+].CCO.CC(=O)O.CC([O-])=O.N#C[BH3-]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]([NH2:8])[C:9]1([CH2:10][CH2:11][CH2:12]1)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19]|US10450315B2_0085
8.8.14|[C&H3&+0&D1:4]-[c:3].[O&H0&+0&D1:2]=[#34]=[O&H0&+0&D1:1]>>[C&H0&+0&D3:4](=[O&H0&+0&D1:2])(-[O&H1&+0&D1:1])-[c:3]|[CH3:1][c:2]1[cH:3][c:4]([c:5]2[cH:6][c:7]([cH:8][c:9]([c:10]2[o:11]1)[C:12]([CH3:13])([CH3:14])[CH3:15])[C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20].[O:21]=[Se]=[O:22]>C1COCCO1.ClC(Cl)Cl.O>[CH3:13][C:12]([CH3:14])([CH3:15])[c:9]1[cH:8][c:7]([cH:6][c:5]2[c:4]([cH:3][c:2]([o:11][c:10]12)[C:1](=[O:22])[OH:21])=[O:20])[C:16]([CH3:17])([CH3:18])[CH3:19]|US20200331900A1_0738
7.3.5|[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[O&H1&D1:1]>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[O&H1&D1:1]|[OH:1][N:2]=[C:3]1[CH2:4][CH:5]([CH2:6]1)[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[O:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[F:20]>[Na+].Cl.CCO.c1ccncc1.B.[OH-]>[OH:1][NH:2][CH:3]1[CH2:4][CH:5]([CH2:6]1)[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[O:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[F:20]|US07138400B2_0240
1.3.7|[c:5]:[c&H0&+0&D3:4](:[n:3])-Cl.[c:2]-[N&H0&+&D3:1](-[O&-])=O>>[c:5]:[c&H0&+0&D3:4](:[n:3])-[N&H1&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[C:9](=[O:10])[O:11][CH3:12])[N+:13]([O-])=O)[S:14][c:15]1[n:16][cH:17][cH:18][n:19][c:20]1Cl>N.C1CCOC1.[Na]>[CH3:12][O:11][C:9](=[O:10])[c:8]1[cH:7][c:6]2[NH:13][c:20]3[n:19][cH:18][cH:17][n:16][c:15]3[S:14][c:5]2[cH:4][c:3]1[O:2][CH3:1]|US20130225614A1_0529
1.6.8|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[NH:15][c:16]1[cH:17][c:18]2[cH:19][cH:20][c:21]([cH:22][c:23]2[c:24]([n:25]1)[Cl:26])[Cl:27].[CH3:28][CH2:29]I>CCOC(C)=O.CN(C)C=O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[N:15]([CH2:29][CH3:28])[c:16]1[cH:17][c:18]2[cH:19][cH:20][c:21]([cH:22][c:23]2[c:24]([n:25]1)[Cl:26])[Cl:27]|US20180265484A1_0123
1.2.1|[C&H3&D1:5]-[C&H1&+0&D2:4]=O.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[NH:8][CH2:9][CH2:10][OH:11].[CH3:12][CH:13]=O>>[CH3:1][c:2]1[cH:7][cH:6][c:5]([cH:4][cH:3]1)[N:8]([CH2:9][CH2:10][OH:11])[CH2:13][CH3:12]|EP3725314A1_0764
7.3.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[N:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[N:1]|[CH3:1][CH2:2][CH:3]1[C:4](=[N:5][N:6]=[C:7]([c:8]2[cH:9][c:10]([c:11]([cH:12][c:13]21)[O:14][CH3:15])[O:16][CH3:17])[c:18]1[cH:19][cH:20][c:21]([c:22]([cH:23]1)[O:24][CH3:25])[O:26][CH3:27])[CH3:28]>O=C(O[Na])O[Na].c1ccccc1.O[Na]>[CH3:25][O:24][c:22]1[cH:23][c:18]([cH:19][cH:20][c:21]1[O:26][CH3:27])[C:7]1=[N:6][NH:5][CH:4]([CH:3]([c:13]2[cH:12][c:11]([c:10]([cH:9][c:8]12)[O:16][CH3:17])[O:14][CH3:15])[CH2:2][CH3:1])[CH3:28]|US20190106427A1_0716
3.9.24|[c:5]-[C&H2&+0&D2:4]-[#12]-Cl.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[c:5]([n:6][c:7]([n:8][c:9]1[Cl:10])[Cl:11])Cl.Cl[Mg][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>[NH4+].[Cl-].Cl.Cc1ccccc1.CCN(CC)CCOc1ccc(cc1)Cc1ccccc1.C1CCOC1.[Ni]>[CH3:1][CH:2]([CH3:3])[c:4]1[c:5]([n:6][c:7]([n:8][c:9]1[Cl:10])[Cl:11])[CH2:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|US20030114668A1_0971
1.3.7|[c:5]-[N&H0&+&D3:4](-[O&-])=O.[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][n:8]1)[N+:9]([O-])=O.[O-:10][N+:11](=[O:12])[c:13]1[cH:14][n:15][c:16]([n:17][c:18]1[OH:19])Cl>O.O.CCO.[Na].[Ni]>[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][n:8]1)[NH:9][c:16]1[n:15][cH:14][c:13]([c:18]([n:17]1)[OH:19])[N+:11]([O-:10])=[O:12]|US08461170B2_0646
1.2.9|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[Br-].[CH3:1][NH:2][C:3]([CH3:4])([CH3:5])[CH2:6][NH:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.O[CH2:16][CH:17]1[CH2:18][CH2:19]1>CCC(C)=O.O=C(O[Na])O[Na].I[Na]>[CH3:4][C:3]([CH3:5])([CH2:6][NH:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[N:2]([CH3:1])[CH2:16][CH:17]1[CH2:18][CH2:19]1|US20190336515A1_0834
7.3.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[O:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[O:1]|[CH3:1][CH2:2][CH:3]([CH3:4])[O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH2:12][CH2:13][C:14]([CH3:15])=[N:16][O:17][CH2:18][CH3:19]>[Na+].Cl.CCO.N#C[BH3-]>[CH3:1][CH2:2][CH:3]([CH3:4])[O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH2:12][CH2:13][CH:14]([CH3:15])[NH:16][O:17][CH2:18][CH3:19]|EP2364293B1_0114
1.2.9|[C&H3&D1:5]-[C&H2&+0&D2:4]-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2]O.[CH3:3][c:4]1[cH:5][c:6]([nH:7][c:8]([cH:9]1)[CH3:10])=[O:11]>CCI.O[K]>[CH3:3][c:4]1[cH:9][c:8]([n:7]([c:6]([cH:5]1)=[O:11])[CH2:2][CH3:1])[CH3:10]|US07084152B2_0131
2.1.18|[C:5]-[N&H1&+0&D2:4]-[c:3].[O&H0&D1:2]=[C&H1&+0&D2:1]-O>>[C:5]-[N&H0&+0&D3:4](-[c:3])-[C&H1&+0&D2:1]=[O&H0&D1:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[NH:12][CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20].[O:21]=[CH:22]O>O.CC(=O)OC(C)=O.O=C(O)O[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N:12]([CH:22]=[O:21])[CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20]|US07576215B2_0414
7.3.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=[N&H0&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-[N&H1&+0&D2:2]-[C:1]|[CH3:1][C:2]1=[N:3][CH2:4][CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12>CCO.ClCCc1ccccc1.[Pd]>[CH3:1][CH:2]1[NH:3][CH2:4][CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21|US07985753B2_0619
1.6.8|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2]I.[O:3]=[c:4]1[c:5]([n:6][nH:7][cH:8][c:9]1-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>[Na+].CN(C)C=O.[H-]>[CH3:1][CH2:2][n:7]1[cH:8][c:9]([c:4]([c:5]([n:6]1)-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)=[O:3])-[c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|EP3484889B1_0060
1.3.7|[c:5]:[c&H0&+0&D3:4](:[c:3])-Cl.[c:2]-[N&H0&+&D3:1](-[O&-])=O>>[c:5]:[c&H0&+0&D3:4](:[c:3])-[N&H1&+0&D2:1]-[c:2]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7][cH:8][cH:9][c:10]2Cl)[n:11]1.[CH3:12][CH2:13][O:14][C:15](=[O:16])[c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[N+:23]([O-])=O)[S:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>>[CH3:12][CH2:13][O:14][C:15](=[O:16])[c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[NH:23][c:10]1[cH:9][cH:8][n:7][c:6]2[n:11][c:2]([cH:3][cH:4][c:5]21)[CH3:1])[S:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1|US04140775A
1.2.1|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[C:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]1=[CH:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[CH:8]([CH3:9])[CH2:10][CH:11]=O.[CH3:12][NH:13][CH2:14][CH2:15][OH:16]>>[CH3:1][C:2]1=[CH:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[CH:8]([CH3:9])[CH2:10][CH2:11][N:13]([CH3:12])[CH2:14][CH2:15][OH:16]|EP3239154A1_0646
3.5.2|[c:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[c&H0&+0&D3:2](:[n:1])-[#12]-Cl>>[c:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[n:3][c:4]2[n:5][o:6][n:7][c:8]2[c:9]([c:10]1[CH2:11]Cl)[NH2:12].[CH3:13][O:14][c:15]1[cH:16][cH:17][c:18]([n:19][cH:20]1)[Mg]Cl>CO.C1CCOC1>[CH3:13][O:14][c:15]1[cH:16][cH:17][c:18]([n:19][cH:20]1)[CH2:11][c:10]1[c:2]([n:3][c:4]2[n:5][o:6][n:7][c:8]2[c:9]1[NH2:12])[CH3:1]|US09994591B2_0779
3.5.4|[C:5]-[C&H2&+0&D2:4]-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][c:11]([n:12][n:13][c:14]1-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[O:21][CH3:22])Cl.[CH2:23]=[CH:24][CH2:25][Mg]Br>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCOC(C)=O.CCOCC.C1CCOC1.O.O>[CH2:23]=[CH:24][CH2:25][c:11]1[cH:10][c:9]([c:14]([n:13][n:12]1)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[O:21][CH3:22])-[c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[O:2][CH3:1]|EP3239143A2_0491
9.7.73|[C:5]-[C&H1&+0&D3:4](-[c:3])-O.[N&+:2]=[N&H0&+0&D2:1]-[#11]>>[C:5]-[C&H1&+0&D3:4](-[c:3])-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][CH2:9][CH2:10][C@@H:11]([OH:12])[CH:13](O)[c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[Cl:20])[Cl:21].[N-:22]=[N+:23]=[N:24][Na]>CN(C)c1ccncc1.CCCCCC.CCOC(C)=O.c1ccncc1.CS(=O)(=O)Cl.Cl[Na].O.Cl>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][CH2:9][CH2:10][C@@H:11]([OH:12])[CH:13]([N:24]=[N+:23]=[N-:22])[c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[Cl:20])[Cl:21]|US08778950B2_0837
1.2.1|[C&H3&D1:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH:11]=O.[CH3:12][NH:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>OCc1ccc(cc1)OCCc1ccccc1.CC(=O)O[BH-](OC(C)=O)OC(C)=O.ClCCCl.[Na+]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][N:13]([CH3:12])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US09206128B2_0467
7.6.1|[C&H3&D1:5]/[C&H1&+0&D2:4]=[C&H0&+0&D3:3](\[C:2])-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1]/[CH:2]=[C:3](\[CH2:4][CH3:5])[c:6]1[cH:7][cH:8][cH:9][c:10]2[nH:11][c:12]([nH:13][c:14]21)=[O:15]>[NH4+].C/C=C(/CC)c1cccc2[nH]c([nH]c21)=O.CCO.[O-]C=O.[Pd]>[CH3:1][CH2:2][CH:3]([CH2:4][CH3:5])[c:6]1[cH:7][cH:8][cH:9][c:10]2[nH:11][c:12]([nH:13][c:14]21)=[O:15]|EP1961745A1_0155
7.3.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][C:2]1([C:3](=[N:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21)[CH3:11])[CH3:12]>CC(=O)O.[O-2].[Pt+2]>[CH3:1][C:2]1([c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]2[NH:4][CH:3]1[CH3:11])[CH3:12]|US07288677B2_0113
7.6.1|[C&H3&D1:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])[C:9](=[CH:10][CH3:11])[c:12]1[cH:13][cH:14][c:15]2[cH:16][c:17]([cH:18][cH:19][c:20]2[cH:21]1)[O:22][CH3:23]>[H][H]>[CH3:23][O:22][c:17]1[cH:18][cH:19][c:20]2[cH:21][c:12]([cH:13][cH:14][c:15]2[cH:16]1)[CH:9]([CH2:10][CH3:11])[C:6]([CH3:7])([CH3:8])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US08877974B2_0101
1.2.1|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[c:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][NH:2][CH:3]=[O:4].[CH3:5][O:6][c:7]1[cH:8][cH:9][c:10]2[s:11][c:12]3[c:13]([cH:14][cH:15][c:16]([c:17]3[c:18]([c:19]2[cH:20]1)=[O:21])[NH:22][CH2:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29])[CH:30]=O>O.O.[Na+].O=CO.[OH-]>[CH3:29][CH2:28][N:25]([CH2:26][CH3:27])[CH2:24][CH2:23][NH:22][c:16]1[cH:15][cH:14][c:13]([c:12]2[s:11][c:10]3[cH:9][cH:8][c:7]([cH:20][c:19]3[c:18]([c:17]12)=[O:21])[O:6][CH3:5])[CH2:30][N:2]([CH3:1])[CH:3]=[O:4]|US20200230123A1_1069
3.9.23|[C&H2&+0&D1:4]=[C&H1&+0&D2:3]-[C:2].[C&H2&+0&D2:1](-I)-I>>[C&H2&+0&D2:4]1-[C&H1&+0&D3:3](-[C:2])-[C&H2&+0&D2:1]-1|[CH2:1]=[CH:2][C:3]12[CH2:4][CH2:5][C:6]([CH:7]=[C:8]1[c:9]1[c:10]([cH:11][c:12]([c:13]([c:14]1[Cl:15])[Cl:16])[O:17][CH2:18][C:19](=[O:20])[O:21][CH2:22][CH3:23])[CH2:24]2)=[O:25].I[CH2:26]I>Cc1ccccc1.C1CCOC1.[Cu].[Zn]>[CH3:23][CH2:22][O:21][C:19](=[O:20])[CH2:18][O:17][c:12]1[cH:11][c:10]2[CH2:24][C:3]3([CH2:4][CH2:5][C:6]([CH:7]=[C:8]3[c:9]2[c:14]([c:13]1[Cl:16])[Cl:15])=[O:25])[CH:2]1[CH2:1][CH2:26]1|EP3419969B1_0239
1.6.4|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][NH:2][CH2:3][CH:4]1[CH2:5][CH2:6]1.Cl[CH2:7][c:8]1[n:9][n:10][c:11]2[CH2:12][N:13]=[C:14]([c:15]3[cH:16][c:17]([cH:18][cH:19][c:20]3-[n:21]12)[Cl:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][c:28]1[Cl:29]>I[K].C1CCOC1>[CH3:1][N:2]([CH2:3][CH:4]1[CH2:5][CH2:6]1)[CH2:7][c:8]1[n:9][n:10][c:11]2[CH2:12][N:13]=[C:14]([c:15]3[cH:16][c:17]([cH:18][cH:19][c:20]3-[n:21]21)[Cl:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][c:28]1[Cl:29]|US20050049245A1_0442
2.1.2|[C:5]-[N&H3&+&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[Cl-].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=[O:10])[CH2:11][NH3+:12].[O:13]=[C:14](O)[c:15]1[cH:16][cH:17][n:18][cH:19][cH:20]1>O.O.O=S(Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=[O:10])[CH2:11][NH:12][C:14](=[O:13])[c:15]1[cH:20][cH:19][n:18][cH:17][cH:16]1|US08957093B2_1023
3.7.3|[C&H3&+0&D1:4]-[#12]-Cl.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][c:2]1[n:3][c:4]([cH:5][n:6]1[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[CH:14]=[O:15].[CH3:16][Mg]Cl>[NH4+].[Cl-].C1CCOC1>[CH3:1][c:2]1[n:3][c:4]([cH:5][n:6]1[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[CH:14]([CH3:16])[OH:15]|EP3548463B1_0073
1.7.11|[C&H3&D1:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][O-:2].[O:3]=[C:4]1[NH:5][C:6]([CH:7]([O:8]1)[c:9]1[c:10]([cH:11][cH:12][cH:13][c:14]1F)[Cl:15])=[O:16]>CO.CS(C)=O>[CH3:1][O:2][c:14]1[cH:13][cH:12][cH:11][c:10]([c:9]1[CH:7]1[O:8][C:4]([NH:5][C:6]1=[O:16])=[O:3])[Cl:15]|US20200039945A1_0891
1.7.11|[C&H3&D1:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Na+].[CH3:1][O-:2].[OH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[S:10][c:11]1[cH:12][cH:13][cH:14][c:15]([n:16]1)F>O.Cl.CO>[CH3:1][O:2][c:15]1[cH:14][cH:13][cH:12][c:11]([n:16]1)[S:10][c:7]1[cH:8][cH:9][c:4]([cH:5][cH:6]1)[OH:3]|EP2459535B1_0161
1.6.2|[C&H3&D1:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2]Br.[cH:3]1[cH:4][cH:5][c:6]2[CH2:7][CH:8]3[CH2:9][NH:10][CH2:11][CH2:12][CH2:13][N:14]3[c:15]2[cH:16]1>O.CN(C)C=O.CC(C)(C)[O-]>[CH3:1][CH2:2][N:10]1[CH2:9][CH:8]2[CH2:7][c:6]3[cH:5][cH:4][cH:3][cH:16][c:15]3[N:14]2[CH2:13][CH2:12][CH2:11]1|EP3150607A1_0263
1.8.15|[C&H3&D1:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C@@:2]([OH:3])([C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([c:11]([c:12]1[Cl:13])[Cl:14])I)[C:15]([F:16])([F:17])[F:18].[CH3:19][S-:20].[Na+]>CC(=O)N(C)C.Cl[Cu]>[CH3:1][C@@:2]([OH:3])([C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([c:11]([c:12]1[Cl:13])[Cl:14])[S:20][CH3:19])[C:15]([F:16])([F:17])[F:18]|EP2986592B1_0129
1.6.4|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[ClH:1].[CH3:2][NH:3][CH:4]1[CH2:5][CH2:6][C:7]2([CH2:8][CH2:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16]2)[CH2:17][CH2:18]1.[O:19]=[C:20]([CH2:21][CH2:22][CH2:23]Cl)[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30]>CN(C)C=O.O=C(O[K])O[K].I[K]>[ClH:1].[CH3:2][N:3]([CH2:23][CH2:22][CH2:21][C:20](=[O:19])[c:24]1[cH:29][cH:28][c:27]([cH:26][cH:25]1)[F:30])[CH:4]1[CH2:5][CH2:6][C:7]2([CH2:17][CH2:18]1)[CH2:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[CH2:16]2|EP3239154A1_0631
9.7.241|[O&H0&D1:4]=[C&H0&+0&D3:3](-[c:2])-C.[O&H0&+0&D2:1](-[#11])-Br>>[O&H0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[O&H1&+0&D1:1]|C[C:1](=[O:2])[c:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[o:10][c:11]1-[c:12]1[cH:13][cH:14][c:15]([c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21)[O:22][CH2:23][CH2:24][Br:25].Br[O:26][Na]>C1COCCO1.O=S(O)O[Na].BrBr.O.[Na]>[O:2]=[C:1]([OH:26])[c:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[o:10][c:11]1-[c:12]1[cH:13][cH:14][c:15]([c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21)[O:22][CH2:23][CH2:24][Br:25]|US06187952B1
3.7.3|[C&H3&+0&D1:4]-[#12]-Cl.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][Mg]Cl.[O:2]=[CH:3][CH2:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1>O.Cl.C1CCOC1.[Mg]>[CH3:1][CH:3]([OH:2])[CH2:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1|US08569341B2_2285
1.6.2|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5]Br.[CH3:6][NH:7][C:8]([CH3:9])([CH3:10])[CH2:11][NH:12][C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CCC(C)=O.O=C(O[Na])O[Na].I[Na]>[CH3:3][C:2]([CH3:1])=[CH:4][CH2:5][N:7]([CH3:6])[C:8]([CH3:9])([CH3:10])[CH2:11][NH:12][C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|EP3725314A1_0674
3.11.91|[C&H3&D1:5]-[C&H2&+0&D2:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[CH2:9][CH3:10].Br[CH2:11][c:12]1[cH:13][cH:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[cH:21]1>CCO.CCO.C1CCOC1.[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[CH:9]([CH3:10])[CH2:11][c:12]1[cH:13][cH:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[cH:21]1|US08309600B2_0650
2.1.2|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H3&+&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][n:7]1)-[c:8]1[nH:9][c:10]2[cH:11][c:12]([cH:13][c:14]3[c:15]2[c:16]1[CH:17]=[N:18][NH:19][C:20]3=[O:21])[NH3+:22].[CH3:23][C:24]([CH3:25])([CH3:26])[O:27][C:28](=[O:29])[NH:30][C@H:31]([CH2:32][CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)[C:40](=[O:41])O.[Cl-]>CN(C)C(On1nnc2c1nccc2)=[N+](C)C.CCN(CC)CC.F[P-](F)(F)(F)(F)F.CN(C)C=O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][n:7]1)-[c:8]1[nH:9][c:10]2[cH:11][c:12]([cH:13][c:14]3[c:15]2[c:16]1[CH:17]=[N:18][NH:19][C:20]3=[O:21])[NH:22][C:40](=[O:41])[C@@H:31]([CH2:32][CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)[NH:30][C:28](=[O:29])[O:27][C:24]([CH3:23])([CH3:25])[CH3:26]|US05604242A
3.9.23|[C&H2&+0&D1:4]=[C&H1&+0&D2:3]-[c:2].[C&H2&+0&D2:1](-I)-I>>[C&H2&+0&D2:4]1-[C&H1&+0&D3:3](-[c:2])-[C&H2&+0&D2:1]-1|[CH2:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[cH:12]1.I[CH2:13]I>CCOCC.[Cu].[Zn]>[cH:7]1[cH:8][cH:9][cH:10][c:11]2[cH:12][c:3]([cH:4][cH:5][c:6]12)[CH:2]1[CH2:1][CH2:13]1|US20090192203A1_0250
1.6.2|[N&H2&D1:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[N&H2&D1:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[NH2:1][NH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[Br:9].Br[CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Br:17].Cl>CCCC[N+](CCCC)(CCCC)CCCC.ClCCl.[Br-]>[NH2:1][N:2]([CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Br:17])[c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[Br:9]|US09063126B2_0831
3.11.52|[C&H3&D1:5]-[C&H2&+0&D2:4]-Br.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2]Br.[N:3]#[C:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1>>[CH3:1][CH2:2][CH:5]([C:4]#[N:3])[c:6]1[cH:11][cH:10][cH:9][cH:8][cH:7]1|US20200046697A1_0190
1.6.2|[C&H3&D1:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[NH:13][CH3:14].[CH3:15][CH2:16][O:17][C:18](=[O:19])[c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1[CH2:26]Br>O.O=C(O)O[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[N:13]([CH3:14])[CH2:26][c:25]1[cH:24][cH:23][cH:22][cH:21][c:20]1[C:18](=[O:19])[O:17][CH2:16][CH3:15]|US20110082133A1_0337
2.1.2|[C:5]-[N&H3&+&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[Cl-].[CH3:1][CH2:2][NH3+:3].[CH3:4][C@H:5]([NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[N:19]1[CH2:20][CH2:21][CH2:22][C@H:23]1[C:24](=[O:25])O>CCN1CCOCC1.CC(C)COC(=O)Cl.CN(C)C=O.C1CCOC1>[CH3:4][C@H:5]([NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[N:19]1[CH2:20][CH2:21][CH2:22][C@H:23]1[C:24](=[O:25])[NH:3][CH2:2][CH3:1]|US07745489B2_0184
1.6.2|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][c:7]([c:8]([cH:9][c:10]1[CH2:11]Br)[Cl:12])[C:13]([CH3:14])([CH3:15])[CH3:16].[CH3:17][NH:18][CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1>ClC(Cl)(Cl)Cl>[CH3:14][C:13]([CH3:15])([CH3:16])[c:7]1[cH:6][c:5]([c:10]([cH:9][c:8]1[Cl:12])[CH2:11][N:18]([CH3:17])[CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1)[NH:4][C:2]([CH3:1])=[O:3]|US20200044154A1_0181
3.9.23|[C&H2&+0&D1:4]=[C&H1&+0&D2:3]-[O:2].[C&H2&+0&D2:1](-I)-I>>[C&H2&+0&D2:4]1-[C&H1&+0&D3:3](-[O:2])-[C&H2&+0&D2:1]-1|[CH2:1]=[CH:2][O:3][CH2:4][CH2:5][CH2:6][C:7]([CH3:8])=[CH:9][CH2:10][CH2:11][C:12]([CH3:13])=[CH:14][CH2:15][CH2:16][CH:17]=[C:18]([CH3:19])[CH2:20][CH2:21][CH:22]=[C:23]([CH3:24])[CH2:25][CH2:26][CH:27]=[C:28]([CH3:29])[CH3:30].I[CH2:31]I>CCOCC.CC[Zn]CC>[CH3:29][C:28]([CH3:30])=[CH:27][CH2:26][CH2:25][C:23]([CH3:24])=[CH:22][CH2:21][CH2:20][C:18]([CH3:19])=[CH:17][CH2:16][CH2:15][CH:14]=[C:12]([CH3:13])[CH2:11][CH2:10][CH:9]=[C:7]([CH3:8])[CH2:6][CH2:5][CH2:4][O:3][CH:2]1[CH2:1][CH2:31]1|EP3333169B1_0408
3.7.2|[C&H3&+0&D1:4]-[#12]-Br.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][CH:2]([CH2:3][CH:4]=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[F:18].[CH3:19][Mg]Br>[NH4+].O.[Cl-].CCOCC>[CH3:1][CH:2]([CH2:3][CH:4]([CH3:19])[OH:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[F:18]|US10500213B2_0858
1.6.2|[C:5]-[N&H1&+0&D2:4]-[c:3].[N&H0&D1:2]#[C&H0&+0&D2:1]-Br>>[C:5]-[N&H0&+0&D3:4](-[c:3])-[C&H0&+0&D2:1]#[N&H0&D1:2]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][NH:6][c:7]1[cH:8][n:9][cH:10][cH:11][n:12]1.[N:13]#[C:14]Br>CCN(CC)CC.C1CCOC1.O[Na]>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][N:6]([C:14]#[N:13])[c:7]1[cH:8][n:9][cH:10][cH:11][n:12]1|US20170101409A1_0351
9.7.242|[O&H0&D1:4]=[C&H0&+0&D3:3](-[c:2])-C.[O&H0&+0&D2:1](-[#11])-Cl>>[O&H0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[O&H1&+0&D1:1]|C[C:1](=[O:2])[c:3]1[cH:4][cH:5][c:6]2[s:7][c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[c:14]2[cH:15]1.Cl[O:16][Na]>Cl.O[Na].C1COCCO1>[O:2]=[C:1]([OH:16])[c:3]1[cH:4][cH:5][c:6]2[s:7][c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[c:14]2[cH:15]1|EP3344604B1_0311
1.6.2|[C&H3&D1:5]-[C&H2&+0&D2:4]-Br.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2]Br.[CH3:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]2[NH:10][C:11]([CH2:12][N:13]=[C:14]([c:15]2[cH:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[F:23])=[O:24]>CC(C)=O.O=C(O[K])O[K]>[CH3:1][CH2:2][N:10]1[C:11]([CH2:12][N:13]=[C:14]([c:15]2[cH:16][c:6]([cH:7][cH:8][c:9]21)[C:4]([CH3:3])=[O:5])[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[F:23])=[O:24]|US20180186753A1_0070
1.6.2|[C:5]-[C&H2&+0&D2:4]-Br.[N&H2&D1:3]-[N&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[N&H0&+0&D3:2](-[N&H2&D1:3])-[c:1]|Cl.[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[NH:8][NH2:9].[CH3:10][c:11]1[cH:12][cH:13][c:14]([cH:15][n:16]1)[CH2:17][CH2:18]Br>CCN(CC)CC>[CH3:10][c:11]1[cH:12][cH:13][c:14]([cH:15][n:16]1)[CH2:17][CH2:18][N:8]([NH2:9])[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH3:1]|US08338408B2_0738
1.6.2|[C&H3&D1:5]-[C&H2&+0&D2:4]-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2]Br.[O:3]=[c:4]1[cH:5][c:6]2[CH2:7][CH2:8][S:9][c:10]3[s:11][c:12]([cH:13][c:14]3-[c:15]2[n:16][nH:17]1)[Br:18]>>[CH3:1][CH2:2][n:17]1[n:16][c:15]2-[c:14]3[cH:13][c:12]([s:11][c:10]3[S:9][CH2:8][CH2:7][c:6]2[cH:5][c:4]1=[O:3])[Br:18]|US20060063785A1_0805
1.8.14|[C&H3&D1:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][S-:2].[O:3]=[C:4]1[c:5]2[cH:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[cH:13][c:14]2[C:15]([c:16]2[cH:17][c:18]([c:19]([cH:20][c:21]12)[F:22])F)=[O:23]>Cl.O=C(O[K])O[K].C1CCOC1>[CH3:1][S:2][c:18]1[cH:17][c:16]2[C:15]([c:14]3[cH:13][c:12]4[cH:11][cH:10][cH:9][cH:8][c:7]4[cH:6][c:5]3[C:4]([c:21]2[cH:20][c:19]1[F:22])=[O:3])=[O:23]|EP3750885A1_0327
3.7.2|[C&H3&+0&D1:4]-[#12]-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][Mg]Br.[O:2]=[CH:3][c:4]1[cH:5][nH:6][c:7]([n:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>C1CCOC1>[CH3:1][CH:3]([OH:2])[c:4]1[cH:5][nH:6][c:7]([n:8]1)-[c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1|EP3356361B1_0164
2.6.2|[C&H3&D1:5]-[C&H1&+0&D3:4](-[O:3])-I.[C:2]-[O&H0&-&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[O:3]|[Na+].[CH3:1][CH2:2][O:3][C:4](=[O:5])[O:6][CH:7]([CH3:8])I.[NH:9]=[c:10]1[nH:11][c:12]([cH:13][s:14]1)[C:15](=[N:16][OH:17])[C:18](=[O:19])[NH:20][CH:21]1[C:22]([N:23]2[C:24](=[C:25]([CH2:26][S:27][C@H:28]12)[CH2:29][O:30][C:31]([NH2:32])=[O:33])[C:34]([O-:35])=[O:36])=[O:37]>O.CCOC(C)=O.CN(C)C=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[O:6][CH:7]([CH3:8])[O:35][C:34](=[O:36])[C:24]1=[C:25]([CH2:26][S:27][C@@H:28]2[CH:21]([C:22]([N:23]12)=[O:37])[NH:20][C:18](=[O:19])[C:15](=[N:16][OH:17])[c:12]1[cH:13][s:14][c:10]([nH:11]1)=[NH:9])[CH2:29][O:30][C:31]([NH2:32])=[O:33]|EP0061162A2_0065
1.6.4|[C&H3&D1:5]-[N&H1&+0&D2:4]-[S:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[S:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][NH:2][S:3](=[O:4])(=[O:5])[CH:6]1[CH2:7][CH2:8][C:9]2[CH2:10][S:11][CH:12]=[CH:13][C:14]=2[O:15]1.Cl[CH2:16][C:17]1([CH2:18][O:19]1)[c:20]1[cH:21][cH:22][cH:23][c:24]([n:25]1)[Cl:26]>CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.O[Na].[Br-]>[CH3:1][N:2]([CH2:16][C:17]1([CH2:18][O:19]1)[c:20]1[cH:21][cH:22][cH:23][c:24]([n:25]1)[Cl:26])[S:3](=[O:4])(=[O:5])[CH:6]1[CH2:7][CH2:8][C:9]2[CH2:10][S:11][CH:12]=[CH:13][C:14]=2[O:15]1|EP0326170A1_0067
1.6.2|[C&H3&D1:5]-[N&H1&+0&D2:4]-[S:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[S:3])-[C&H2&+0&D2:1]-[C:2]|[CH2:1]=[CH:2][CH2:3]Br.[CH3:4][C:5]([NH2:6])=[CH:7][C:8](=[O:9])[CH2:10][S:11](=[O:12])(=[O:13])[NH:14][CH3:15]>CN(C)C=O.O=C(O[K])O[K]>[CH2:1]=[CH:2][CH2:3][N:14]([CH3:15])[S:11](=[O:12])(=[O:13])[CH2:10][C:8](=[O:9])[CH:7]=[C:5]([CH3:4])[NH2:6]|EP2275404A1_0277
1.6.4|[N&H2&D1:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[N&H2&D1:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[NH:10][NH2:11].Cl[CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19].[ClH:20]>CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.CCCCCC.CCOCC.CCOCC.[Na+].[Br-].[OH-]>[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[N:10]([NH2:11])[CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19].[ClH:20]|US09625475B2_0995
1.6.2|[C&H3&D1:5]-[N&H1&+0&D2:4]-[c:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][C:10]12[CH2:11][CH:12]3[CH2:13][CH:14]([CH2:15][CH:16]([CH2:17]3)[CH2:18]1)[CH2:19]2.[CH3:20][C:21]#[C:22][CH2:23]Br>c1ccccc1.CN(C)C=O.[O-]C([O-])=O.[K+].[K+]>[CH3:20][C:21]#[C:22][CH2:23][N:2]([CH3:1])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][C:10]12[CH2:11][CH:12]3[CH2:13][CH:14]([CH2:15][CH:16]([CH2:17]3)[CH2:18]1)[CH2:19]2|US20200362174A1_0101
1.6.4|[C&H3&D1:5]-[N&H1&+0&D2:4]-[c:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]1([O:3][CH2:4][CH2:5][O:6]1)[CH2:7][CH2:8][CH2:9]Cl.[CH3:10][NH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>CN(C)C=O.O=C(O[K])O[K].I[K]>[CH3:10][N:11]([CH2:9][CH2:8][CH2:7][C:2]1([O:3][CH2:4][CH2:5][O:6]1)[CH3:1])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US20060094764A1_0044
1.6.2|[C&H3&D1:5]-[C&H2&+0&D2:4]-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2]Br.[O:3]=[c:4]1[cH:5][cH:6][s:7][c:8]2[c:9]3[cH:10][cH:11][cH:12][cH:13][c:14]3[nH:15][c:16]12>>[CH3:1][CH2:2][n:15]1[c:16]2[c:8]([s:7][cH:6][cH:5][c:4]2=[O:3])[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21|US20200347045A1_0558
1.6.4|[C&H3&D1:5]-[N&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[F:9].Cl[CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]>[Na+].CC([O-])=O.II>[CH3:1][N:2]([CH2:10][c:11]1[cH:16][cH:15][c:14]([cH:13][cH:12]1)[Cl:17])[c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[F:9]|US20190389867A1_0480
1.6.2|[C:5]-[N&H1&+0&D2:4]-[C:3].[N&H0&D1:2]#[C&H0&+0&D2:1]-Br>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H0&+0&D2:1]#[N&H0&D1:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([n:7][c:8]([n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14])[N:15]1[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1)[NH2:21].[N:22]#[C:23]Br>CN(C)C=O>[CH3:14][O:13][c:12]1[cH:11][c:10]2[n:9][c:8]([n:7][c:6]([c:5]2[cH:4][c:3]1[O:2][CH3:1])[NH2:21])[N:15]1[CH2:16][CH2:17][N:18]([CH2:19][CH2:20]1)[C:23]#[N:22]|EP3237391B1_0386
3.11.91|[C&H3&D1:5]-[C&H2&+0&D2:4]-[C:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][C:3](=[O:4])[OH:5].[CH3:6][C:7]#[C:8][CH2:9]Br>CN(C)P(=O)(N(C)C)N(C)C.CC(C)NC(C)C.CCCCCC.CCCC[Li].C1CCOC1>[CH3:6][C:7]#[C:8][CH2:9][CH:2]([CH3:1])[C:3](=[O:4])[OH:5]|US08158790B2_0921
1.7.7|[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-O.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH:2](O)[c:3]1[cH:4][cH:5][n:6][c:7]2[n:8][cH:9][n:10][n:11]21.[OH:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)N=NC(=O)OCC.C1CCOC1>[CH3:1][CH:2]([O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19])[c:3]1[cH:4][cH:5][n:6][c:7]2[n:8][cH:9][n:10][n:11]21|US08022206B2_0184
2.1.1|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-F.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[CH3:1][CH:2]([CH3:3])[CH:4]([NH:5][C:6](=[O:7])[O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[C:16](=[O:17])F.[CH3:18][O:19][C:20](=[O:21])[c:22]1[cH:23][n:24][cH:25][cH:26][c:27]1[NH2:28]>CC(C)N(CC)C(C)C.ClCCl>[CH3:18][O:19][C:20](=[O:21])[c:22]1[cH:23][n:24][cH:25][cH:26][c:27]1[NH:28][C:16](=[O:17])[CH:4]([NH:5][C:6](=[O:7])[O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[CH:2]([CH3:1])[CH3:3]|EP0201193A2_0208
1.7.11|[C&H3&D1:5]-[O&H0&-&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[Na+].[CH3:1][O-:2].[O:3]=[C:4]([NH:5][S:6](=[O:7])(=[O:8])[c:9]1[c:10]([cH:11][cH:12][cH:13][c:14]1[Cl:15])[Cl:16])[c:17]1[cH:18][s:19][c:20]([n:21]1)Br>CO>[CH3:1][O:2][c:20]1[n:21][c:17]([cH:18][s:19]1)[C:4](=[O:3])[NH:5][S:6](=[O:7])(=[O:8])[c:9]1[c:14]([cH:13][cH:12][cH:11][c:10]1[Cl:16])[Cl:15]|US20160237071A1_0416
1.8.12|[C&H3&D1:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][S-:2].[NH2:3][c:4]1[cH:5][cH:6][cH:7][c:8]2[cH:9][n:10][cH:11][c:12]([c:13]12)Br>>[CH3:1][S:2][c:12]1[cH:11][n:10][cH:9][c:8]2[cH:7][cH:6][cH:5][c:4]([c:13]21)[NH2:3]|EP2925743B1_0318
1.8.13|[C&H3&D1:5]-[S&H0&-&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Cl:1][c:2]1[n:3][c:4]([n:5][c:6]([n:7]1)[Cl:8])Cl.[CH3:9][S-:10].[Na+]>Cc1ccccc1>[CH3:9][S:10][c:4]1[n:5][c:6]([n:7][c:2]([n:3]1)[Cl:1])[Cl:8]|US20200115363A1_0326
2.1.37|[C:5]=[N&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:5]=[N&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][C:10](=[O:11])O.[CH3:12][N:13]1[CH2:14][CH2:15][S:16][C:17]1=[NH:18].I>CCN(CC)CC.CCOC(=O)Cl.ClCCl>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][C:10](=[O:11])[N:18]=[C:17]1[S:16][CH2:15][CH2:14][N:13]1[CH3:12]|US08541448B2_0693
2.1.2|[C:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][CH:2]1[CH2:3][c:4]2[cH:5][c:6]3[O:7][CH2:8][O:9][c:10]3[cH:11][c:12]2[C:13](=[N:14][N:15]1[C:16](=[O:17])O)[c:18]1[cH:19][cH:20][c:21]([c:22]([cH:23]1)[CH3:24])[N+:25]([O-:26])=[O:27].[NH2:28][CH:29]1[CH2:30][CH2:31]1.c1cnc[n-]1>>[CH3:24][c:22]1[cH:23][c:18]([cH:19][cH:20][c:21]1[N+:25]([O-:26])=[O:27])[C:13]1=[N:14][N:15]([CH:2]([CH2:3][c:4]2[cH:5][c:6]3[O:7][CH2:8][O:9][c:10]3[cH:11][c:12]12)[CH3:1])[C:16](=[O:17])[NH:28][CH:29]1[CH2:30][CH2:31]1|US20100048543A1_0861
1.2.5|[C&H3&D1:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][NH2:2].O=[C:3]1[CH2:4][CH2:5][CH2:6][N:7]([CH2:8]1)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>CCO.[H][H].[O-2].[Pt+2]>[CH3:1][NH:2][CH:3]1[CH2:8][N:7]([CH2:6][CH2:5][CH2:4]1)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US20040121965A1_0833
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[S:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[S:1])-[c:3]|[CH3:1][C:2](=O)[c:3]1[cH:4][c:5]([c:6]([c:7]([cH:8]1)[F:9])[NH:10][S:11]([CH3:12])(=[O:13])=[O:14])[F:15].[CH3:16][C:17]([CH3:18])([CH3:19])[S:20]([NH2:21])=[O:22]>CCO[Ti](OCC)(OCC)OCC.C1CCOC1.O.[Na+].[Cl-]>[CH3:12][S:11](=[O:13])(=[O:14])[NH:10][c:6]1[c:7]([cH:8][c:3]([cH:4][c:5]1[F:15])[C:2]([CH3:1])=[N:21][S:20](=[O:22])[C:17]([CH3:16])([CH3:18])[CH3:19])[F:9]|US20190315715A1_0600
2.1.2|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[NH2:1][c:2]1[c:3]([cH:4][c:5]([cH:6][c:7]1[N+:8]([O-:9])=[O:10])[C:11]([F:12])([F:13])[F:14])[N+:15]([O-:16])=[O:17].[O:18]=[C:19](O)[C:20]([F:21])([F:22])[F:23]>O=C(Cl)C(F)(F)F.c1ccncc1.CCO>[O-:16][N+:15](=[O:17])[c:3]1[cH:4][c:5]([cH:6][c:7]([c:2]1[NH:1][C:19](=[O:18])[C:20]([F:21])([F:22])[F:23])[N+:8]([O-:9])=[O:10])[C:11]([F:12])([F:13])[F:14]|US20160137639A1_3357
1.7.11|[C&H3&D1:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Na+].[CH3:1][O-:2].[O:3]=[S:4]([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][n:13][c:14]([cH:15][cH:16]1)Br>CO>[CH3:1][O:2][c:14]1[cH:15][cH:16][c:11]([cH:12][n:13]1)[S:4](=[O:3])[c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1|EP2903977B1_0631
1.2.9|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[O&H1&D1:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&D1:1]|[NH:1]=[C:2]([NH2:3])[NH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH:12][C:13]([NH2:14])=[O:15].[NH2:16][CH2:17][CH2:18][CH2:19][NH:20][CH2:21][CH2:22][CH2:23][CH2:24][NH:25][C:26](=[O:27])[CH:28]([OH:29])O.Cl.Cl.Cl>N=C(N)NCCCCCCC=CC(=O)NC(O)C(N)=O.O=C(O)CCCC(=O)O.O.Cl.Cl.Cl>[NH:1]=[C:2]([NH2:3])[NH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH:12][C:13](=[O:15])[NH:14][CH:28]([OH:29])[C:26](=[O:27])[NH:25][CH2:24][CH2:23][CH2:22][CH2:21][NH:20][CH2:19][CH2:18][CH2:17][NH2:16]|US06320059B1
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[N:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[N:1])-[c:3]|[CH3:1][O:2][C:3](=[O:4])[NH:5][NH2:6].[CH3:7][C:8](=O)[c:9]1[n:10][c:11]([nH:12][c:13]1[CH3:14])-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>Cc1ccccc1>[CH3:1][O:2][C:3](=[O:4])[NH:5][N:6]=[C:8]([CH3:7])[c:9]1[n:10][c:11]([nH:12][c:13]1[CH3:14])-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|EP3628669A1_0398
1.2.3|[C:5]-[N&H2&+0&D1:4].[N&H2&D1:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:2](-[N&H2&D1:3])-[c:1]|[NH2:1][CH:2]=[O:3].[NH2:4][C:5](=O)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH:12]([F:13])[F:14]>>[NH2:4][C:5](=[N:1][CH:2]=[O:3])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH:12]([F:13])[F:14]|US09716235B2_0245
2.1.1|[C:5]-[N&H3&+&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][CH2:2][C@:3]1([C:4]([O:5][CH2:6][c:7]2[c:8]([n:9]3[CH2:10][c:11]4[c:12]([n:13][c:14]5[cH:15][cH:16][cH:17][cH:18][c:19]5[c:20]4[CH2:21][CH2:22][Si:23]([CH3:24])([CH3:25])[CH2:26][NH3+:27])-[c:28]3[cH:29][c:30]21)=[O:31])=[O:32])[O:33][C:34]([CH3:35])=[O:36].[CH3:37][N:38]([CH3:39])[C:40](=[O:41])Cl.[O-]C(=O)C(F)(F)F>O=C(O[K])O[K]>[CH3:1][CH2:2][C@:3]1([C:4]([O:5][CH2:6][c:7]2[c:30]1[cH:29][c:28]1-[c:12]3[n:13][c:14]4[cH:15][cH:16][cH:17][cH:18][c:19]4[c:20]([c:11]3[CH2:10][n:9]1[c:8]2=[O:31])[CH2:21][CH2:22][Si:23]([CH3:24])([CH3:25])[CH2:26][NH:27][C:40](=[O:41])[N:38]([CH3:37])[CH3:39])=[O:32])[O:33][C:34]([CH3:35])=[O:36]|EP0273239A1_0101
1.3.8|[C&H3&D1:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][NH2:2].[N:3]#[C:4][c:5]1[c:6]([cH:7][cH:8][cH:9][c:10]1F)[NH2:11]>CCO>[CH3:1][NH:2][c:10]1[cH:9][cH:8][cH:7][c:6]([c:5]1[C:4]#[N:3])[NH2:11]|EP3597653A1_0425
9.7.92|[C:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[O&H1&D1:1]|Cl.[NH2:1][OH:2].[O:3]=[C:4]([OH:5])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[C:13]([CH2:14][CH:15]([C:16]=1[CH:17]=[CH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[OH:25])=O>[Na+].CO.CC([O-])=O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O[Na]>[O:3]=[C:4]([OH:5])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1=[C:16]([CH:15]([CH2:14][C:13]1=[N:1][OH:2])[OH:25])[CH:17]=[CH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|US07601722B2_1354
1.8.12|[C&H3&D1:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[s:8][c:9]([n:10][c:11]12)[NH:12][C:13](=[O:14])[c:15]1[cH:16][cH:17][n:18][c:19]([cH:20]1)Br)[N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1.[CH3:27][S-:28].[Na+]>C1COCCO1.CN(C)C=O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[s:8][c:9]([n:10][c:11]12)[NH:12][C:13](=[O:14])[c:15]1[cH:16][cH:17][n:18][c:19]([cH:20]1)[S:28][CH3:27])[N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1|US20200115384A1_0258
1.2.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH2:8])[CH3:9].[CH3:10][C:11](=[O:12])[CH:13]([CH3:14])O>c1ccccc1>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH:8][CH:13]([CH3:14])[C:11]([CH3:10])=[O:12])[CH3:9]|US10398689B2_0418
1.2.9|[C&H3&D1:5]-[N&H2&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-O>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][NH2:2].O[CH:3]1[CH2:4][N:5]([CH2:6]1)[CH:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>CN(C)C=O.CS(=O)(=O)Cl.c1ccncc1>[CH3:1][NH:2][CH:3]1[CH2:6][N:5]([CH2:4]1)[CH:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US07408065B2_0604
2.1.5|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[S:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[S:1])=[O&H0&D1:3]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[O:11]=[S:12](=[O:13])([NH:14][C@H:15]1[CH2:16][N:17]([C@@H:18]([CH2:19]1)/[CH:20]=[CH:21]\[CH2:22][CH2:23][CH2:24][C:25](=[O:26])O)[S:27](=[O:28])(=[O:29])[c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[Cl:36])[c:37]1[cH:38][cH:39][c:40]([cH:41][cH:42]1)[Cl:43]>CN(C)c1ccncc1.ClCCl.C(=NC1CCCCC1)=NC1CCCCC1>[O:26]=[C:25]([CH2:24][CH2:23][CH2:22]/[CH:21]=[CH:20]\[C@@H:18]1[CH2:19][C@H:15]([CH2:16][N:17]1[S:27](=[O:28])(=[O:29])[c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[Cl:36])[NH:14][S:12](=[O:11])(=[O:13])[c:37]1[cH:38][cH:39][c:40]([cH:41][cH:42]1)[Cl:43])[NH:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1|EP2305640A2_0313
2.6.2|[C&H3&D1:5]-[C&H1&+0&D3:4](-[O:3])-I.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[O:3]|[CH3:1]/[CH:2]=[CH:3]\[C:4]1[CH2:5][S:6][C@@H:7]2[CH:8]([C:9]([N:10]2[C:11]=1[C:12](=[O:13])[OH:14])=[O:15])[NH:16][C:17](=[O:18])/[C:19](=[N:20]\[OH:21])[c:22]1[cH:23][s:24][c:25]([n:26]1)[NH2:27].[CH3:28][CH:29](I)[O:30][C:31](=[O:32])[O:33][CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]1>C1COCCOCCOCCOCCOCCO1.CC(=O)OCC.CN(C)C=O.[O-]C([O-])=O.[K+].[K+]>[CH3:28][CH:29]([O:30][C:31](=[O:32])[O:33][CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]1)[O:14][C:12](=[O:13])[C:11]1=[C:4]([CH2:5][S:6][C@H:7]2[N:10]1[C:9]([CH:8]2[NH:16][C:17](=[O:18])/[C:19](=[N:20]\[OH:21])[c:22]1[cH:23][s:24][c:25]([n:26]1)[NH2:27])=[O:15])/[CH:3]=[CH:2]\[CH3:1]|EP0667868B1_0150
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][OH:2].[O:3]=[C:4]1[NH:5][C:6]([CH:7]([O:8]1)[c:9]1[c:10]([cH:11][cH:12][cH:13][c:14]1F)[F:15])=[O:16]>CS(C)=O.CC(C)(C)O[K]>[CH3:1][O:2][c:14]1[cH:13][cH:12][cH:11][c:10]([c:9]1[CH:7]1[O:8][C:4]([NH:5][C:6]1=[O:16])=[O:3])[F:15]|EP2970186B1_0179
2.6.2|[N:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](O)[c:3]1[cH:4][nH:5][c:6]2[n:7][c:8]([n:9][cH:10][c:11]2[c:12]1=[O:13])[N:14]1[CH2:15][CH2:16][N:17]([CH2:18][CH2:19]1)[CH:20]=[O:21].[O:22]=[C:23]1[CH2:24][CH2:25][C:26]([N:27]1[OH:28])=[O:29]>CCN(CC)CC.CC(C)OC(=O)Cl.CN(C)C=O.ClCCl>[O:1]=[C:2]([O:28][N:27]1[C:26]([CH2:25][CH2:24][C:23]1=[O:22])=[O:29])[c:3]1[cH:4][nH:5][c:6]2[n:7][c:8]([n:9][cH:10][c:11]2[c:12]1=[O:13])[N:14]1[CH2:19][CH2:18][N:17]([CH2:16][CH2:15]1)[CH:20]=[O:21]|US20180362485A1_0847
1.2.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:1]-[C:2]|[ClH:1].[CH3:2][C:3](=O)[CH2:4][CH2:5][c:6]1[cH:7][cH:8][c:9]2[O:10][CH2:11][O:12][c:13]2[cH:14]1.[NH2:15][CH2:16][CH2:17][c:18]1[cH:19][cH:20][c:21]([c:22]([cH:23]1)[OH:24])[OH:25]>CCO.O=C(O)O[Na].[O-2].[Pt+2]>[ClH:1].[CH3:2][CH:3]([CH2:4][CH2:5][c:6]1[cH:7][cH:8][c:9]2[O:10][CH2:11][O:12][c:13]2[cH:14]1)[NH:15][CH2:16][CH2:17][c:18]1[cH:19][cH:20][c:21]([c:22]([cH:23]1)[OH:24])[OH:25]|US20200030260A1_0202
1.2.3|[C&H3&D1:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C&H3&D1:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[c:1]|O=[C:1]1[CH2:2][CH2:3][CH:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[CH3:17][NH2:18]>O=C(c1ccccc1)c1ccccc1.c1ccccc1.Cl[Ti](Cl)(Cl)Cl>[CH3:17][N:18]=[C:1]1[CH2:2][CH2:3][CH:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US09073894B2_0415
1.2.9|[C&H3&D1:5]-[N&H2&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[c:1])-O>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|O[CH:1]1[CH2:2][CH:3]([c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]21)[c:10]1[cH:11][cH:12][cH:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21.[CH3:20][NH2:21]>CCN(CC)CC.Cc1ccccc1.C1CCOC1>[CH3:20][NH:21][CH:1]1[CH2:2][CH:3]([c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]21)[c:10]1[cH:11][cH:12][cH:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21|US08791132B2_1559
1.2.6|[C:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[N&H2&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[N&H2&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]12[CH2:10][CH2:11][C:12]([CH:13]([CH2:14]2)[NH:15][C:16]1=[O:17])=O.[NH2:18][NH2:19].O>c1ccccc1.CCO>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]12[CH2:10][CH2:11][C:12]([CH:13]([CH2:14]2)[NH:15][C:16]1=[O:17])=[N:18][NH2:19]|EP2958928B1_0112
1.2.3|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH:2]([CH3:3])[n:4]1[c:5]([n:6][c:7]2[cH:8][c:9]([cH:10][c:11]([c:12]21)[NH2:13])[C:14]([F:15])([F:16])[F:17])[CH3:18].[CH3:19][C:20](=O)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>Cc1ccccc1C>[CH3:19][C:20](=[N:13][c:11]1[cH:10][c:9]([cH:8][c:7]2[n:6][c:5]([n:4]([c:12]21)[CH:2]([CH3:1])[CH3:3])[CH3:18])[C:14]([F:15])([F:16])[F:17])[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1|US10633370B2_0196
1.8.14|[C&H3&D1:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[nH:3][c:4]([s:5][c:6]1[C:7](=[O:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)F)=[O:15].[CH3:16][SH:17]>CCO>[CH3:1][c:2]1[nH:3][c:4]([s:5][c:6]1[C:7](=[O:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[S:17][CH3:16])=[O:15]|US08742112B2_0371
1.8.13|[C&H3&D1:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][S-:2].[O-:3][N+:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][n:11]1)Cl>CCO>[CH3:1][S:2][c:9]1[cH:8][cH:7][c:6]([n:11][cH:10]1)[N+:4]([O-:3])=[O:5]|EP3334711B1_0330
2.6.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-O.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[c:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])/[CH:8]=[CH:9]\[C@H:10]1[C@H:11]([C:12]1([CH3:13])[CH3:14])[C:15](=[O:16])[OH:17].[CH3:18][CH:19](O)[c:20]1[cH:21][cH:22][cH:23][c:24]([n:25]1)[O:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1ccncc1.ClCCl>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])/[CH:8]=[CH:9]\[C@H:10]1[C@H:11]([C:12]1([CH3:13])[CH3:14])[C:15](=[O:16])[O:17][CH:19]([CH3:18])[c:20]1[cH:21][cH:22][cH:23][c:24]([n:25]1)[O:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1|US07217731B2_0129
2.1.37|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H1&+0&D1:2]=[c:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H0&+0&D2:2]=[c:1])=[O&H0&D1:3]|[CH3:1][c:2]1[cH:3][n:4]([c:5]([s:6]1)=[NH:7])-[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[C:14]([F:15])([F:16])[F:17].[O:18]=[C:19](O)[CH:20]([F:21])[F:22].Cl>CN(C)CCCN=C=NCC.CCN(CC)CC.ClC(Cl)Cl.Cl>[CH3:1][c:2]1[cH:3][n:4]([c:5]([s:6]1)=[N:7][C:19](=[O:18])[CH:20]([F:21])[F:22])-[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[C:14]([F:15])([F:16])[F:17]|US20200087323A1_0324
8.4.3|[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C:2].[O&H1&+0&D1:1]-O>>[C&H3&D1:5]-[N&H0&+&D4:4](-[C:3])(-[C:2])-[O&H0&-&D1:1]|[CH3:1][N:2]1[CH2:3][CH2:4][C:5]([CH2:6][CH2:7]1)=[C:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[CH:15]=[CH:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]12.[OH:23]O>CO.[Pt]>[CH3:1][N+:2]1([CH2:3][CH2:4][C:5]([CH2:6][CH2:7]1)=[C:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[CH:15]=[CH:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]12)[O-:23]|US09951048B1_0834
1.2.6|[C:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[N&H2&D1:1]>>[C:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[N&H2&D1:1])-[c:3]|O.[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=[O:9])[C:10](=O)[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[CH3:17].[NH2:18][NH2:19]>CCO>[CH3:17][c:14]1[cH:13][cH:12][c:11]([cH:16][cH:15]1)[C:10](=[N:18][NH2:19])[C:8](=[O:9])[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH3:1]|US20180155296A1_1769
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[N:1]>>[C&H3&D1:5]/[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]/[N:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])=O.[CH3:8][CH2:9][O:10][c:11]1[cH:12][cH:13][cH:14][c:15]([c:16]1[CH2:17][NH:18][NH2:19])[Cl:20]>[O-]S([O-])(=O)=O.ClC(Cl)(Cl)[2H].[Mg+2]>[CH3:8][CH2:9][O:10][c:11]1[cH:12][cH:13][cH:14][c:15]([c:16]1[CH2:17][NH:18]/[N:19]=[C:6](/[CH3:7])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[Cl:20]|EP1370561B1_0202
1.2.9|[C&H3&D1:5]-[C&H0&+0&D3:4](=[C:3])-O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[C:3])-[N&H1&+0&D2:1]-[C:2]|Cl.[CH2:1]=[CH:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[O:11][CH2:12][CH:13]([OH:14])[CH2:15][NH2:16].[CH3:17][C:18](O)=[CH:19][C:20](=[O:21])[c:22]1[cH:23][n:24][cH:25][cH:26][cH:27]1>CCO.[K]>[CH2:1]=[CH:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[O:11][CH2:12][CH:13]([OH:14])[CH2:15][NH:16][C:18]([CH3:17])=[CH:19][C:20](=[O:21])[c:22]1[cH:27][cH:26][cH:25][n:24][cH:23]1|EP1764367A1_0190
2.6.1|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-F>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][NH:2][CH:3]([CH2:4][N:5]1[CH2:6][CH:7]([CH2:8]1)[OH:9])[C:10]([F:11])([F:12])[F:13].[O:14]=[C:15](F)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>[O-]C(=O)O.ClCCl.O.[Na+]>[CH3:1][NH:2][CH:3]([CH2:4][N:5]1[CH2:6][CH:7]([CH2:8]1)[O:9][C:15](=[O:14])[c:16]1[cH:21][cH:20][cH:19][cH:18][cH:17]1)[C:10]([F:11])([F:12])[F:13]|US09045427B2_0128
2.1.3|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[N:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N:1])=[O&H0&D1:3]|[O:1]=[C:2](O)[CH2:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[C:10]([F:11])([F:12])[F:13].[NH2:14][NH:15][C:16]([NH2:17])=[S:18]>CN(C)C=O.O=S(Cl)Cl>[NH2:17][C:16](=[S:18])[NH:15][NH:14][C:2](=[O:1])[CH2:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[C:10]([F:11])([F:12])[F:13]|US08629167B2_0689
1.2.3|[C&H3&D1:5]-[C&H0&+0&D3:4](-[N:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[c:1])-[N:3]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[CH3:8][C:9](=O)[N:10]([CH3:11])[CH3:12]>NC(=O)c1ccccc1.c1ccccc1.CC(N)=O>[CH3:11][N:10]([CH3:12])[C:9]([CH3:8])=[N:1][c:2]1[cH:7][cH:6][cH:5][cH:4][cH:3]1|US09549932B2_0703
1.7.7|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-O.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH:2](O)[CH2:3][c:4]1[c:5]([n:6]([c:7]2[n:8][cH:9][cH:10][cH:11][c:12]2[c:13]1[OH:14])-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)=[O:21]>O.[Na+].Br.CC([O-])=O>[CH3:1][CH:2]1[CH2:3][c:4]2[c:5]([n:6]([c:7]3[n:8][cH:9][cH:10][cH:11][c:12]3[c:13]2[O:14]1)-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)=[O:21]|US20060257987A1_1831
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Na+].C[O-].[CH3:1][OH:2].F[c:3]1[cH:4][c:5]2[n:6][cH:7][n:8][c:9]([c:10]2[cH:11][n:12]1)[NH:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[Br:20]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[n:6][cH:7][n:8][c:9]([c:10]2[cH:11][n:12]1)[NH:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[Br:20]|EP3240537B1_0736
1.2.9|[C&H3&D1:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-O>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|O[c:1]1[n:2][c:3]([n:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[I:11])-[c:12]1[cH:13][n:14][cH:15][cH:16][n:17]1.[CH3:18][NH2:19]>CN(C)[P+](On1nnc2ccccc21)(N(C)C)N(C)C.C1CN=C2CCCCCN2C1.F[P-](F)(F)(F)(F)F.C1CCOC1>[CH3:18][NH:19][c:1]1[n:2][c:3]([n:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[I:11])-[c:12]1[cH:13][n:14][cH:15][cH:16][n:17]1|US20120309739A1_0435
7.6.1|[N:6]-[C&H0&+0&D3:5]1-[C:4]-[C:3]-[C&H0&+0&D3:2]=1-[c:1]>>[N:6]-[C&H1&+0&D3:5]1-[C:4]-[C:3]-[C&H1&+0&D3:2]-1-[c:1]|[O:1]=[C:2]([NH:3][C:4]1[CH2:5][CH2:6][C:7]=1[c:8]1[cH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[s:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[C:23]([F:24])([F:25])[F:26]>CO>[O:1]=[C:2]([NH:3][CH:4]1[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[s:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[C:23]([F:24])([F:25])[F:26]|US10207985B2_0700
1.7.11|[C&H3&D1:5]-[O&H0&-&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Na+].[CH3:1][O-:2].[NH2:3][c:4]1[n:5][cH:6][n:7][c:8]2[c:9]1[n:10][c:11]([n:12]2[C@H:13]1[CH2:14][C@@H:15]([C@H:16]([O:17]1)[CH2:18][OH:19])[OH:20])Br>CO>[CH3:1][O:2][c:11]1[n:10][c:9]2[c:4]([n:5][cH:6][n:7][c:8]2[n:12]1[C@H:13]1[CH2:14][C@@H:15]([C@H:16]([O:17]1)[CH2:18][OH:19])[OH:20])[NH2:3]|US20060052382A1_0429
1.2.3|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:1]-[C:2])-[c:3]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[NH:9][C:10](=[O:11])[C:12]([Cl:13])([Cl:14])[Cl:15].[NH2:16][CH2:17][CH2:18][OH:19]>CCO>[CH3:1][C:2](=[N:16][CH2:17][CH2:18][OH:19])[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[NH:9][C:10](=[O:11])[C:12]([Cl:13])([Cl:14])[Cl:15]|US20200317659A1_0675
1.2.3|[C&H3&D1:5]-[C&H0&+0&D3:4](-[N:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:1]-[C:2])-[N:3]|[CH3:1][C:2](=O)[N:3]1[CH2:4][C@@H:5]([CH2:6][CH2:7][C@H:8]([CH:9]1[CH2:10][NH2:11])[NH:12][C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[c:20]1[cH:21][cH:22][cH:23][c:24]([c:25]1[F:26])[F:27]>CC(=O)O.O=C(O)O[Na]>[CH3:17][C:16]([CH3:18])([CH3:19])[O:15][C:13](=[O:14])[NH:12][C@@H:8]1[CH2:7][CH2:6][C@H:5]([CH2:4][N:3]2[C:2](=[N:11][CH2:10][CH:9]12)[CH3:1])[c:20]1[cH:21][cH:22][cH:23][c:24]([c:25]1[F:26])[F:27]|US10392389B2_1716
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][OH:2].[OH:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1I>[O-]C([O-])=O.I[Cu].c1ccc2ccc3cccnc3c2n1.[Cs+].[Cs+]>[CH3:1][O:2][c:10]1[cH:9][cH:8][cH:7][cH:6][c:5]1[CH2:4][OH:3]|US20200071302A1_0187
2.1.1|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-F>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[O:1]=[C:2](F)[C:3]([F:4])([O:5][C:6]([F:7])([F:8])[C:9]([F:10])([O:11][C:12]([F:13])([F:14])[C:15]([F:16])([O:17][C:18]([F:19])([F:20])[C:21]([F:22])([F:23])[C:24]([F:25])([F:26])[F:27])[C:28]([F:29])([F:30])[F:31])[C:32]([F:33])([F:34])[F:35])[C:36]([F:37])([F:38])[F:39].[CH2:40]=[CH:41][CH2:42][NH2:43]>Cl>[CH2:40]=[CH:41][CH2:42][NH:43][C:2](=[O:1])[C:3]([F:4])([O:5][C:6]([F:7])([F:8])[C:9]([F:10])([O:11][C:12]([F:13])([F:14])[C:15]([F:16])([O:17][C:18]([F:19])([F:20])[C:21]([F:22])([F:23])[C:24]([F:25])([F:26])[F:27])[C:28]([F:29])([F:30])[F:31])[C:32]([F:34])([F:35])[F:33])[C:36]([F:38])([F:39])[F:37]|US08022107B2_0108
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[N:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[N:1]|[CH3:1][CH2:2][CH2:3][CH2:4][O:5][C:6](=[O:7])[CH2:8][CH2:9][C:10]([CH3:11])=O.[CH3:12][CH2:13][C:14]([CH3:15])([CH3:16])[NH:17][NH2:18]>>[CH3:12][CH2:13][C:14]([CH3:15])([CH3:16])[NH:17][N:18]=[C:10]([CH3:11])[CH2:9][CH2:8][C:6](=[O:7])[O:5][CH2:4][CH2:3][CH2:2][CH3:1]|US20200255427A1_0467
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][OH:2].[I:3][c:4]1[cH:5][n:6][cH:7][c:8]([n:9]1)I>O.[Na]>[CH3:1][O:2][c:8]1[cH:7][n:6][cH:5][c:4]([n:9]1)[I:3]|EP3270920B1_0073
1.7.11|[C&H3&D1:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)Cl)[CH2:16][CH2:17][CH2:18][C:19](=[O:20])[OH:21].[CH3:22][O-:23].[K+]>CO>[CH3:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[O:23][CH3:22])[CH2:16][CH2:17][CH2:18][C:19](=[O:20])[OH:21]|US20200024264A1_1184
2.1.2|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[O:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[O:1])=[O&H0&D1:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][C:10](=[O:11])O.[NH2:12][O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.Cl>CC(C)COC(=O)Cl.CCN(CC)CC.C1CCOC1.CCO.O=C=O.CO.O[K]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][C:10](=[O:11])[NH:12][O:13][CH2:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|US20110105474A1_0226
2.6.2|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[OH:10].[O:11]=[C:12]([NH:13][CH2:14][C:15](=[O:16])O)[O:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>OP(Oc1ccccc1)Oc1ccccc1.Cl[Hg]Cl.c1ccncc1>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][C:15](=[O:16])[CH2:14][NH:13][C:12](=[O:11])[O:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|US07714161B2_0255
1.7.3|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH2:2][OH:3].[CH3:4][CH2:5][n:6]1[n:7][cH:8][c:9]2[n:10][c:11]([c:12]([n:13][c:14]21)[CH3:15])[C:16](=[O:17])O>CCI.[Na]>[CH3:1][CH2:2][O:3][C:16](=[O:17])[c:11]1[n:10][c:9]2[cH:8][n:7][n:6]([c:14]2[n:13][c:12]1[CH3:15])[CH2:5][CH3:4]|US10336775B2_0537
1.2.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:1]-[C:2]|[CH3:1][CH:2](O)[CH2:3][c:4]1[cH:5][cH:6][cH:7][s:8]1.[NH2:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17]>Cc1ccc(cc1)S(=O)(=O)Cl.Cc1ccccc1.CCN(CC)CC.O>[CH3:1][CH:2]([CH2:3][c:4]1[cH:5][cH:6][cH:7][s:8]1)[NH:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17]|US20180222899A1_0238
1.8.13|[C&H3&D1:5]-[S&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Na+].[CH3:1][c:2]1[cH:3][c:4]2[n:5]([n:6]1)[c:7]([c:8]1[cH:9][n:10][c:11]([cH:12][c:13]1[n:14]2[CH3:15])Cl)=[O:16].[CH3:17][S-:18]>CN(C)C=O>[CH3:1][c:2]1[cH:3][c:4]2[n:5]([n:6]1)[c:7]([c:8]1[cH:9][n:10][c:11]([cH:12][c:13]1[n:14]2[CH3:15])[S:18][CH3:17])=[O:16]|US09951043B2_1326
9.7.92|[C:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[O&H1&D1:1])-[c:3]|Cl.[CH3:1][C:2]1([CH2:3][c:4]2[cH:5][c:6]([c:7]([c:8]([c:9]2[C:10]1=O)[Cl:11])[Cl:12])[O:13][CH2:14][C:15](=[O:16])[OH:17])[CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1.[NH2:23][OH:24]>Cl.c1ccncc1>[CH3:1][C:2]1([CH2:3][c:4]2[cH:5][c:6]([c:7]([c:8]([c:9]2[C:10]1=[N:23][OH:24])[Cl:11])[Cl:12])[O:13][CH2:14][C:15](=[O:16])[OH:17])[CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1|EP0149242B1_0059
1.2.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[c:3]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[F:15])[F:16].[CH3:17][C:18](=O)[c:19]1[cH:20][n:21][cH:22][cH:23][cH:24]1>CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(=O)O.ClCCl.[Na+]>[CH3:17][CH:18]([NH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[F:15])[F:16])[c:19]1[cH:24][cH:23][cH:22][n:21][cH:20]1|US20170217850A1_1079
2.6.2|[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3])-O.[O&H1&+0&D1:2]-[c:1]>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|[O:1]=[C:2](O)[c:3]1[cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[cH:11][c:12]1[OH:13].[OH:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O=P(Cl)(Cl)Cl>[O:1]=[C:2]([O:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:3]1[cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[cH:11][c:12]1[OH:13]|US09278910B2_0342
2.6.2|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][OH:5].[CH3:6][CH:7]([CH3:8])[C:9](=[O:10])O>>[CH3:1][CH2:2][CH2:3][CH2:4][O:5][C:9](=[O:10])[CH:7]([CH3:6])[CH3:8]|US07449475B2_0848
1.7.11|[C&H3&D1:5]-[O&H0&-&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Na+].[CH3:1][O-:2].[CH3:3][CH2:4][CH:5]([CH3:6])[NH:7][c:8]1[n:9][c:10]([n:11][c:12]([c:13]1[N+:14]([O-:15])=[O:16])[CH3:17])Cl>CO>[CH3:3][CH2:4][CH:5]([CH3:6])[NH:7][c:8]1[n:9][c:10]([n:11][c:12]([c:13]1[N+:14]([O-:15])=[O:16])[CH3:17])[O:2][CH3:1]|US20190106437A1_0919
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[O:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[O:1]|Cl.[CH3:1][C:2](=O)[C:3](=[N:4][OH:5])[C:6](=[O:7])[N:8]([CH3:9])[CH3:10].[CH3:11][O:12][NH2:13]>CCO.c1ccncc1>[CH3:11][O:12][N:13]=[C:2]([CH3:1])[C:3](=[N:4][OH:5])[C:6](=[O:7])[N:8]([CH3:9])[CH3:10]|EP1914229B1_0609
1.3.3|[C&H3&D1:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][NH2:2].[Br:3][c:4]1[cH:5][cH:6][c:7]2[n:8][c:9]([n:10][cH:11][c:12]2[cH:13]1)-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)I>[Pd]>[CH3:1][NH:2][c:17]1[cH:18][cH:19][c:14]([cH:15][cH:16]1)-[c:9]1[n:10][cH:11][c:12]2[cH:13][c:4]([cH:5][cH:6][c:7]2[n:8]1)[Br:3]|US20200377464A1_0341
2.8.4|[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3])-O.[S&H1&+0&D1:2]-[c:1]>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[S&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]2[c:10]([cH:11][cH:12][cH:13][n:14]2[c:15]1=[O:16])[SH:17].[CH3:18][CH2:19][O:20][C:21](=[O:22])[c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[C:29](=[O:30])O>c1ccccc1.CN(C)C=O.O=S(Cl)Cl>[CH3:18][CH2:19][O:20][C:21](=[O:22])[c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[C:29](=[O:30])[S:17][c:10]1[cH:11][cH:12][cH:13][n:14]2[c:15]([c:6]([cH:7][n:8][c:9]12)[C:4](=[O:5])[O:3][CH2:2][CH3:1])=[O:16]|EP2399925B1_0060
1.7.11|[C&H3&D1:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Na+].[CH3:1][O-:2].[CH3:3][n:4]1[c:5]([cH:6][n:7][c:8]1-[c:9]1[n:10][n:11][c:12]2[cH:13][cH:14][c:15]([n:16][n:17]12)Cl)[N+:18]([O-:19])=[O:20]>CO.C1COCCO1>[CH3:3][n:4]1[c:5]([cH:6][n:7][c:8]1-[c:9]1[n:10][n:11][c:12]2[cH:13][cH:14][c:15]([n:16][n:17]12)[O:2][CH3:1])[N+:18]([O-:19])=[O:20]|EP1221444A1_0288
1.7.11|[C&H3&D1:5]-[O&H0&-&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][O-:2].[N:3]#[C:4][c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1Br)[C:11]([F:12])([F:13])[F:14]>>[CH3:1][O:2][c:10]1[cH:9][cH:8][c:7]([cH:6][c:5]1[C:4]#[N:3])[C:11]([F:12])([F:13])[F:14]|EP3166927B1_0049
1.2.3|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[c:1]|[CH3:1][C:2](=O)[C:3](=[N:4][OH:5])[C:6](=[O:7])[N:8]([CH3:9])[CH3:10].[CH3:11][O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[NH2:19]>Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:11][O:12][c:13]1[cH:18][cH:17][c:16]([cH:15][cH:14]1)[N:19]=[C:2]([CH3:1])[C:3](=[N:4][OH:5])[C:6](=[O:7])[N:8]([CH3:9])[CH3:10]|US10662268B2_0082
2.8.4|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[S&H0&+0&D2:2]-[c:1]|[O:1]=[C:2]1[CH:3]([C@@H:4]2[N:5]1[CH:6]([C:7](=[CH:8][S:9]2)[C:10](=[O:11])O)[C:12](=[O:13])[O:14][CH:15]([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[NH:28][C:29](=[O:30])[CH2:31][c:32]1[cH:33][cH:34][cH:35][s:36]1.[SH:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1>CCOC(=O)Cl.CCOC(C)=O.CN1CCOCC1.ClCCl>[O:13]=[C:12]([O:14][CH:15]([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[CH:6]1[C:7](=[CH:8][S:9][C@H:4]2[N:5]1[C:2]([CH:3]2[NH:28][C:29](=[O:30])[CH2:31][c:32]1[cH:33][cH:34][cH:35][s:36]1)=[O:1])[C:10](=[O:11])[S:37][c:38]1[cH:43][cH:42][cH:41][cH:40][cH:39]1|EP0188816A1_0085
2.6.2|[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3])-O.[O&H1&+0&D1:2]-[n:1]>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[O&H0&+0&D2:2]-[n:1])-[c:3]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[n:14][cH:15][c:16]([s:17]1)-[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[C:24](=[O:25])O.[OH:26][n:27]1[n:28][n:29][c:30]2[cH:31][cH:32][cH:33][cH:34][c:35]21>Cl.CCN=C=NCCCN(C)C.ClCCl>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[n:14][cH:15][c:16]([s:17]1)-[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[C:24](=[O:25])[O:26][n:27]1[n:28][n:29][c:30]2[cH:31][cH:32][cH:33][cH:34][c:35]21|US20090054413A1_0282
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[O:1]>>[C&H3&D1:5]/[C&H0&+0&D3:4](=[N&H0&+0&D2:2]\[O:1])-[c:3]|[CH3:1][O:2][NH2:3].[CH3:4][C:5](=O)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[NH:18][C:19](=[O:20])[c:21]1[c:22]([n:23][n:24]([c:25]1[F:26])[CH3:27])[CH3:28])[F:29]>>[CH3:27][n:24]1[n:23][c:22]([c:21]([c:25]1[F:26])[C:19](=[O:20])[NH:18][c:17]1[cH:16][cH:15][c:14]([cH:13][c:12]1-[c:9]1[cH:10][cH:11][c:6]([cH:7][cH:8]1)[C:5](/[CH3:4])=[N:3]/[O:2][CH3:1])[F:29])[CH3:28]|US20140309244A1_0601
2.6.1|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-F>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH2:1]=[CH:2][CH2:3][C:4]([F:5])([F:6])[C:7](=[O:8])F.[CH3:9][CH2:10][OH:11]>C=CCOC(F)=C(F)F.CCN(CC)CC>[CH2:1]=[CH:2][CH2:3][C:4]([F:5])([F:6])[C:7](=[O:8])[O:11][CH2:10][CH3:9]|EP3731329A1_0670
2.1.2|[C:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH:2]1[CH2:3][N:4]([CH2:5][CH:6]1[NH2:7])[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH3:15][C:16]([CH3:17])([CH3:18])[O:19][C:20](=[O:21])O>CO>[CH3:15][C:16]([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[NH:7][CH:6]1[CH2:5][N:4]([CH2:3][CH:2]1[CH3:1])[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US09045443B2_0601
2.6.1|[N:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-F.[O&H1&+0&D1:2]-[c:1]>>[N:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][N:2]([S:3][S:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11]([CH3:12])([CH3:13])[CH3:14])[C:15](=[O:16])F.[CH3:17][C:18]1([CH2:19][c:20]2[cH:21][cH:22][cH:23][c:24]([c:25]2[O:26]1)[OH:27])[CH3:28]>CCN(CC)CC.C1COCCO1.O>[CH3:12][C:11]([CH3:13])([CH3:14])[c:8]1[cH:7][cH:6][c:5]([cH:10][cH:9]1)[S:4][S:3][N:2]([CH3:1])[C:15](=[O:16])[O:27][c:24]1[cH:23][cH:22][cH:21][c:20]2[CH2:19][C:18]([O:26][c:25]21)([CH3:17])[CH3:28]|EP0067503A1_0088
1.7.9|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[C:2]-[O&H0&-&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])=[O&H0&D1:3]|[CH3:1][CH:2]([CH2:3][C:4](=[O:5])Cl)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[F:18])[F:19].[CH3:20][C:21]([CH3:22])([CH3:23])[O-:24].[K+]>C1CCOC1>[CH3:1][CH:2]([CH2:3][C:4](=[O:5])[O:24][C:21]([CH3:20])([CH3:22])[CH3:23])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[F:18])[F:19]|US07511162B2_0054
2.1.1|[C:5]-[N&H3&+&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C@@:6]12[CH2:7][C@H:8]1[CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@@H:16]([C:17]([N:18]1[CH2:19][C@@H:20]([CH2:21][C@H:22]1[C:23]([NH:24]2)=[O:25])[O:26][c:27]1[n:28][c:29]2[cH:30][cH:31][cH:32][cH:33][c:34]2[n:35][c:36]1-[c:37]1[cH:38][cH:39][cH:40][s:41]1)=[O:42])[NH3+:43].[O:44]=[C:45](Cl)[O:46][CH:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1.[Cl-]>CC(C)N(CC)C(C)C.ClCCl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C@@:6]12[CH2:7][C@H:8]1[CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@@H:16]([C:17]([N:18]1[CH2:19][C@@H:20]([CH2:21][C@H:22]1[C:23]([NH:24]2)=[O:25])[O:26][c:27]1[n:28][c:29]2[cH:30][cH:31][cH:32][cH:33][c:34]2[n:35][c:36]1-[c:37]1[cH:38][cH:39][cH:40][s:41]1)=[O:42])[NH:43][C:45](=[O:44])[O:46][CH:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1|US20200024309A1_2347
2.1.2|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[C@@H:7]([C:8]([N:9]2[C:10]=1[C:11](=[O:12])[O:13][CH:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)=[O:27])[NH2:28].[CH3:29][C:30]([CH3:31])([CH3:32])[O:33][C:34](=[O:35])[NH:36][C@@H:37]([C:38](=[O:39])O)[c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1>C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C=O.ClCCl>[CH3:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[C@@H:7]([C:8]([N:9]2[C:10]=1[C:11](=[O:12])[O:13][CH:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)=[O:27])[NH:28][C:38](=[O:39])[C@H:37]([NH:36][C:34](=[O:35])[O:33][C:30]([CH3:29])([CH3:31])[CH3:32])[c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1|US07405228B2_0879
2.1.1|[C:5]-[N&H3&+&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:7])Cl.[CH3:8][CH2:9][O:10][C:11]1([CH2:12][CH2:13]1)[NH3+:14].[Cl-]>CCN(CC)CC.C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:7])[NH:14][C:11]1([CH2:12][CH2:13]1)[O:10][CH2:9][CH3:8]|US09908848B2_0345
2.6.2|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N:2]-[O&H1&+0&D1:1]>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:1]-[N:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:16][CH2:17][C:18](=[O:19])O.[OH:20][N:21]([CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[CH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>CCN(CC)CC.C(C#[O+])#[O+].[Cl-].[Cl-]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:16][CH2:17][C:18](=[O:19])[O:20][N:21]([CH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)[CH2:22][c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1|EP0458561A1_0026
1.2.3|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]/[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:1]\[C:2]|[CH3:1][C:2](=[O:3])[O:4][C@H:5]1[C@@H:6]([O:7][CH2:8][C@H:9]([C@@H:10]1[O:11][C:12]([CH3:13])=[O:14])[O:15][C:16]([CH3:17])=[O:18])[CH2:19][C:20]([CH3:21])=O.[NH2:22][CH2:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>CO>[CH3:1][C:2](=[O:3])[O:4][C@@H:5]1[C@H:10]([C@@H:9]([CH2:8][O:7][C@H:6]1[CH2:19]/[C:20]([CH3:21])=[N:22]/[CH2:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[O:15][C:16]([CH3:17])=[O:18])[O:11][C:12]([CH3:13])=[O:14]|EP1914229A1_0510
1.2.9|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[S&H0&D1:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[S&H0&D1:1]|[CH3:1][CH2:2][C:3]1[CH2:4][S:5][C@@H:6]2[C@@H:7]([C:8]([N:9]2[C:10]=1[C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[NH2:19].O[C:20](=[S:21])[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>C(=NC1CCCCC1)=NC1CCCCC1.N=C=N.ClCCl>[CH3:15][C:14]([CH3:16])([CH3:17])[O:13][C:11](=[O:12])[C:10]1=[C:3]([CH2:4][S:5][C@@H:6]2[C@@H:7]([C:8]([N:9]12)=[O:18])[NH:19][C:20](=[S:21])[CH2:22][c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1)[CH2:2][CH3:1]|EP1350790A1_0052
2.1.1|[C:5]-[N&H3&+&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[NH3+:9][C:10]1([CH2:11][CH2:12]1)[OH:13].[Cl-]>CCN(CC)CC.C1CCOC1>[O:1]=[C:2]([NH:9][C:10]1([CH2:11][CH2:12]1)[OH:13])[c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1|US20110046147A1_0123
1.2.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][C:5]([CH3:6])=O.[NH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[NH:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>[O-][Cr]([O-])=O.[H][H].[Cu+2]>[CH3:6][CH:5]([CH2:4][CH:2]([CH3:1])[CH3:3])[NH:7][c:8]1[cH:13][cH:12][c:11]([cH:10][cH:9]1)[NH:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|EP2220073B1_0333
1.3.8|[C&H3&D1:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][NH2:2].[NH2:3][S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][cH:10][c:11]([n:12]1)F>>[CH3:1][NH:2][c:11]1[cH:10][cH:9][cH:8][c:7]([n:12]1)[S:4]([NH2:3])(=[O:5])=[O:6]|US20200317665A1_0297
1.2.9|[C&H3&D1:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|O[c:1]1[cH:2][cH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[cH:10]1.[CH3:11][NH2:12]>c1ccc(cc1)OP(Oc1ccccc1)Oc1ccccc1.O>[CH3:11][NH:12][c:1]1[cH:2][cH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[cH:10]1|US20130131018A1_1422
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[S:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[S:1]|[CH3:1][C:2](=O)[C@H:3]1[O:4][C@@H:5]2[S:6][C:7](=[N:8][C@@H:9]2[C@H:10]([C@@H:11]1[O:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[N:28]([CH3:29])[CH3:30].[CH3:31][C:32]([CH3:33])([CH3:34])[S:35]([NH2:36])=[O:37]>CCO[Ti](OCC)(OCC)OCC.C1CCOC1>[CH3:29][N:28]([CH3:30])[C:7]1=[N:8][C@H:9]2[C@H:5]([O:4][C@@H:3]([C@H:11]([C@@H:10]2[O:20][CH2:21][c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[O:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[C:2]([CH3:1])=[N:36][S:35](=[O:37])[C:32]([CH3:31])([CH3:33])[CH3:34])[S:6]1|US20190365718A1_1235
2.1.37|[C:5]=[N&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:5]=[N&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH:1]=[C:2]1[NH:3][SH:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12)(=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[CH3:18][C:19](=[O:20])[O:21][c:22]1[cH:23][cH:24][cH:25][cH:26][c:27]1[C:28](=[O:29])O>CCN(CC)CC.ClC(Cl)Cl>[CH3:18][C:19](=[O:20])[O:21][c:22]1[cH:23][cH:24][cH:25][cH:26][c:27]1[C:28](=[O:29])[N:1]=[C:2]1[NH:3][SH:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12)(=[O:11])[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US04165377A
2.8.4|[C:5]-[S&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:5]-[S&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][CH:2]([CH2:3][SH:4])[C:5](=[O:6])[N:7]1[c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[CH2:14][CH:15]1[C:16](=[O:17])O>CN(C)c1ccncc1.ClCCl.C(=NC1CCCCC1)=NC1CCCCC1>[CH3:1][CH:2]1[CH2:3][S:4][C:16]([CH:15]2[CH2:14][c:13]3[cH:12][cH:11][cH:10][cH:9][c:8]3[N:7]2[C:5]1=[O:6])=[O:17]|US09834512B2_0108
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[O:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[O:1])-[c:3]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[Cl:9])[Cl:10].[NH2:11][O:12][CH2:13][C:14](=[O:15])[OH:16]>[Na+].CCO.CC([O-])=O>[CH3:1][C:2](=[N:11][O:12][CH2:13][C:14](=[O:15])[OH:16])[c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[Cl:9])[Cl:10]|US20200347071A1_1366
1.2.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])-[c:3]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][n:6][cH:7][cH:8]1.[NH2:9][CH2:10][CH2:11][CH2:12][NH2:13]>O.Cc1ccccc1>[CH3:1][CH:2]([NH:13][CH2:12][CH2:11][CH2:10][NH2:9])[c:3]1[cH:4][cH:5][n:6][cH:7][cH:8]1|EP1281702B1_0259
1.2.5|[C&H3&D1:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][N:3]1[CH2:4][CH2:5][C:6]([c:7]2[cH:8][cH:9][cH:10][c:11]([c:12]21)[CH2:13][S:14][c:15]1[n:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[nH:23]1)=O.[CH3:24][NH2:25]>[Na+].CO.[BH4-]>[CH3:24][NH:25][CH:6]1[CH2:5][CH2:4][N:3]([c:12]2[c:11]([cH:10][cH:9][cH:8][c:7]21)[CH2:13][S:14][c:15]1[n:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[nH:23]1)[CH2:2][CH3:1]|EP3040331A1_0438
2.1.2|[C:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](O)[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH3:16][C:17]([CH3:18])([CH3:19])[NH2:20]>c1ccncc1.CCOCC.O=S(Cl)Cl>[CH3:16][C:17]([CH3:18])([CH3:19])[NH:20][C:2](=[O:1])[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[CH2:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US08828987B2_0894
2.6.2|[C&H3&D1:5]-[C&H1&+0&D3:4](-[O:3])-Cl.[C:2]-[O&H0&-&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[O:3]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[C:24]([O-:25])=[O:26].[CH3:27][CH2:28][O:29][CH:30]([CH3:31])Cl.[Na+]>CN(C)P(=O)(N(C)C)N(C)C.O>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[C:24](=[O:26])[O:25][CH:30]([CH3:31])[O:29][CH2:28][CH3:27]|EP3008062B1_0368
1.2.3|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:1]-[C:2]|[CH3:1][C:2](=O)[C:3]#[N:4].[N:5]#[C:6]/[C:7]([NH2:8])=[C:9](/[NH2:10])[C:11]#[N:12]>>[CH3:1][C:2]([C:3]#[N:4])=[N:8][C:7](/[C:6]#[N:5])=[C:9](\[NH2:10])[C:11]#[N:12]|US07781438B2_0203
2.1.3|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[n:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[n:1])=[O&H0&D1:3]|[NH2:1][n:2]1[cH:3][cH:4][cH:5][c:6]1[C:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[O:15]=[C:16]([NH:17][CH2:18][C:19](=[O:20])O)[O:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>ClCCl.C(=NC1CCCCC1)=NC1CCCCC1>[O:15]=[C:16]([NH:17][CH2:18][C:19](=[O:20])[NH:1][n:2]1[cH:3][cH:4][cH:5][c:6]1[C:7](=[O:8])[c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1)[O:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|US20110269783A1_0204
2.8.4|[C:5]-[S&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:5]-[S&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][C@H:2]([CH2:3][SH:4])[C:5](=[O:6])[N:7]1[CH2:8][S:9][CH2:10][C@H:11]1[C:12](=[O:13])[OH:14].[CH3:15][C:16](=[O:17])[NH:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[C:25](=[O:26])O>CC(C)COC(=O)Cl.CCN(CC)CC.C1CCOC1.O>[CH3:15][C:16](=[O:17])[NH:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[C:25](=[O:26])[S:4][CH2:3][C@@H:2]([CH3:1])[C:5](=[O:6])[N:7]1[CH2:8][S:9][CH2:10][C@H:11]1[C:12](=[O:13])[OH:14]|US20200165255A1_0518
1.7.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-Br.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])Br.[OH:8][CH2:9][CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23]>CN(C)C=O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[O:8][CH2:9][CH2:10][c:11]1[cH:16][cH:15][c:14]([cH:13][cH:12]1)-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23]|US20200289514A1_0334
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][OH:2].Cl[c:3]1[n:4][cH:5][cH:6][n:7][c:8]1[Cl:9]>O.[Na]>[CH3:1][O:2][c:3]1[n:4][cH:5][cH:6][n:7][c:8]1[Cl:9]|EP3064491B1_0128
2.4.5|[C:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[NH2:1][CH2:2][CH2:3][C@H:4]([OH:5])[C:6](=[O:7])[OH:8].[O:9]=[C:10](Cl)[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>O.CO.O[Na].Br[K]>[O:7]=[C:6]([OH:8])[C@@H:4]([OH:5])[CH2:3][CH2:2][NH:1][C:10](=[O:9])[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US07220727B2_0183
2.1.1|[C:5]=[N&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:5]=[N&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][O:2][C:3](=[O:4])Cl.[CH3:5][S:6][C:7](=[NH:8])[NH2:9].O=S(=O)(O)O>O.O[K]>[CH3:5][S:6][C:7]([NH2:9])=[N:8][C:3](=[O:4])[O:2][CH3:1]|US07101902B2_0101
1.3.7|[C&H3&D1:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|O.[CH3:1][n:2]1[cH:3][c:4]([c:5]([nH:6][c:7]1=[O:8])=[O:9])[CH:10]1[c:11]2[n:12][c:13]([s:14][c:15]2[CH:16]=[CH:17][c:18]2[cH:19][c:20]([cH:21][cH:22][c:23]21)[Cl:24])Cl.[CH3:25][NH2:26]>CCO>[CH3:1][n:2]1[cH:3][c:4]([c:5]([nH:6][c:7]1=[O:8])=[O:9])[CH:10]1[c:23]2[cH:22][cH:21][c:20]([cH:19][c:18]2[CH:17]=[CH:16][c:15]2[s:14][c:13]([n:12][c:11]21)[NH:26][CH3:25])[Cl:24]|US20040235916A1_0366
2.6.1|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][C@:2]12[CH2:3][CH2:4][C@@H:5]3[c:6]4[cH:7][cH:8][c:9]([cH:10][c:11]4[CH2:12][CH2:13][C@H:14]3[C@@H:15]1[CH2:16][CH2:17][C:18]2=[O:19])[OH:20].[O:21]=[C:22](Cl)[CH2:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>O.c1ccncc1>[CH3:1][C@:2]12[CH2:3][CH2:4][C@@H:5]3[c:6]4[cH:7][cH:8][c:9]([cH:10][c:11]4[CH2:12][CH2:13][C@H:14]3[C@@H:15]1[CH2:16][CH2:17][C:18]2=[O:19])[O:20][C:22](=[O:21])[CH2:23][c:24]1[cH:29][cH:28][cH:27][cH:26][cH:25]1|US10781275B2_0461
9.7.163|[C&H0&-&D1:5]#[N&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[CH2:14][CH2:15][C:16](=[O:17])[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)F.[C-:24]#[N:25].[K+]>CC(C)(C)OC(=O)OC(=O)OC(C)(C)C.CCOC(C)=O.CS(C)=O.[O-]C([O-])=O.I[Li].[K+].[K+]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[CH2:14][CH2:15][C:16](=[O:17])[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[C:24]#[N:25]|US20200197391A1_0624
2.1.1|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Br.[C:2]-[N&H2&+0&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[CH2:8][NH2:9])[Cl:10].[CH3:11][CH:12]([Br:13])[C:14](=[O:15])Br>CCN(CC)CC.ClCCCl>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[CH2:8][NH:9][C:14](=[O:15])[CH:12]([CH3:11])[Br:13])[Cl:10]|EP3696269A1_0243
2.1.11|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[n:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[n:1])=[O&H0&D1:3]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[n:8][n:9][n:10]2[NH2:11].[O:12]=[C:13](Cl)[CH2:14][CH2:15][Br:16]>CCN(CC)CC.c1ccccc1>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[n:8][n:9][n:10]2[NH:11][C:13](=[O:12])[CH2:14][CH2:15][Br:16]|US20110269740A1_0907
1.6.4|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-Cl.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH:2](Cl)[CH2:3][N:4]1[CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[NH2:16][C:17](=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[NH2:25].Cl.Cl.[ClH:26]>CC([O-])=O.ClC(Cl)Cl.CCO.O.[Na+]>[CH3:1][CH:2]([CH2:3][N:4]1[CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[NH:25][c:24]1[cH:23][cH:22][cH:21][cH:20][c:19]1[C:17]([NH2:16])=[O:18].[ClH:26]|US05965614A
1.8.13|[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[S&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=[O:12])Cl.[CH3:13][O:14][C:15](=[O:16])[c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[SH:23])[CH3:24]>CCN(CC)CC.C1CCOC1.O>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=[O:12])[S:23][c:21]1[cH:22][c:17]([cH:18][cH:19][c:20]1[CH3:24])[C:15](=[O:16])[O:14][CH3:13]|US20130273183A1_0058
9.7.82|[C&H0&-&D1:5]#[N&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[C-:1]#[N:2].[CH3:3][c:4]1[n:5][c:6]([cH:7][n:8]1-[c:9]1[cH:10][c:11]2[cH:12][cH:13][c:14]([nH:15][c:16]2[c:17]([cH:18]1)[CH3:19])=[O:20])I.[Cu+]>N.CC(=O)O[Pd]OC(C)=O.CN1CCCC1=O>[CH3:19][c:17]1[cH:18][c:9]([cH:10][c:11]2[cH:12][cH:13][c:14]([nH:15][c:16]12)=[O:20])-[n:8]1[cH:7][c:6]([n:5][c:4]1[CH3:3])[C:1]#[N:2]|US20190284179A1_0320
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][OH:2].[CH3:3][CH2:4][NH:5][c:6]1[cH:7][c:8]([c:9]([cH:10][c:11]1[N+:12]([O-:13])=[O:14])[C:15]([F:16])([F:17])[F:18])Cl>CCOc1cccc(c1)N>[CH3:3][CH2:4][NH:5][c:6]1[cH:7][c:8]([c:9]([cH:10][c:11]1[N+:12]([O-:13])=[O:14])[C:15]([F:16])([F:17])[F:18])[O:2][CH3:1]|EP3057950B1_0313
2.1.1|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H1&+0&D1:2]=[c:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H0&+0&D2:2]=[c:1])=[O&H0&D1:3]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[s:7][c:8]([n:9]([c:10]21)[NH2:11])=[NH:12].[CH3:13][CH2:14][C:15](=[O:16])Cl>CCN(CC)CC.C1CCOC1.O>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[s:7][c:8]([n:9]([c:10]12)[NH2:11])=[N:12][C:15](=[O:16])[CH2:14][CH3:13]|US20070197577A1_0544
1.8.12|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-Br.[S&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3]([CH3:4])([CH3:5])[CH2:6][CH2:7][CH2:8][CH:9]([CH3:10])Br.[CH3:11][CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[SH:19]>O.CCO.[Na]>[CH3:11][CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[S:19][CH:9]([CH3:10])[CH2:8][CH2:7][CH2:6][C:3]([CH3:4])([CH3:5])[O:2][CH3:1]|EP3013796B9_0505
1.3.7|[C&H3&D1:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[c:2]1[nH:3][n:4][c:5]2[cH:6][cH:7][c:8]([n:9][n:10]12)Cl.[CH3:11][NH2:12]>c1ccccc1>[CH3:11][NH:12][c:8]1[cH:7][cH:6][c:5]2[n:4][nH:3][c:2]([n:10]2[n:9]1)=[O:1]|US20130150325A1_1194
2.6.1|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:12]([CH2:13][CH:14]([C:15]=1[CH:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[OH:24])=[O:25].[O:26]=[C:27](Cl)[CH2:28][Cl:29]>c1ccncc1.C1COCCO1.O>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:12]([CH2:13][CH:14]([C:15]=1[CH:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[O:24][C:27](=[O:26])[CH2:28][Cl:29])=[O:25]|US20150250169A1_0277
2.6.2|[C&H3&D1:5]-[C&H1&+0&D3:4](-[O:3])-Cl.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[O:3]|[CH3:1][C:2]1([C@@H:3]([N:4]2[C:5]([CH2:6][C@H:7]2[S:8]1(=[O:9])=[O:10])=[O:11])[C:12](=[O:13])[OH:14])[CH3:15].[CH3:16][CH2:17][O:18][C:19](=[O:20])[O:21][CH:22]([CH3:23])Cl>CCN(CC)CC.CCOC(C)=O.CN(C)C=O.Br[Na].O>[CH3:16][CH2:17][O:18][C:19](=[O:20])[O:21][CH:22]([CH3:23])[O:14][C:12](=[O:13])[C@@H:3]1[N:4]2[C:5]([CH2:6][C@H:7]2[S:8]([C:2]1([CH3:1])[CH3:15])(=[O:9])=[O:10])=[O:11]|EP2825528B1_0105
1.7.9|[N:5]-[C&H0&+0&D3:4](=[S&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[N:5]-[C&H0&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])=[S&H0&D1:3]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[OH:9])[O:10][CH3:11].[CH3:12][N:13]([CH3:14])[C:15](=[S:16])Cl>CN(C)C=O.[NaH]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[O:9][C:15](=[S:16])[N:13]([CH3:12])[CH3:14])[O:10][CH3:11]|EP2563122B1_0117
1.3.7|[C&H3&D1:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([c:8]([c:9]([cH:10]1)[N+:11]([O-:12])=[O:13])Cl)[N+:14]([O-:15])=[O:16].[CH3:17][NH2:18]>CCO.O>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([c:8]([c:9]([cH:10]1)[N+:11]([O-:12])=[O:13])[NH:18][CH3:17])[N+:14]([O-:15])=[O:16]|EP3490989B1_0136
2.6.1|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[CH2:11][CH2:12][C@@H:13]1[C@@H:14]2[CH2:15][CH2:16][C@:17]2([C@H:18]1[CH2:19][CH2:20][C@@H:21]2[OH:22])[CH3:23].[O:24]=[C:25](Cl)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>O.CO.c1ccncc1>[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[CH2:11][CH2:12][C@@H:13]1[C@@H:14]2[CH2:15][CH2:16][C@:17]2([C@H:18]1[CH2:19][CH2:20][C@@H:21]2[O:22][C:25](=[O:24])[c:26]1[cH:31][cH:30][cH:29][cH:28][cH:27]1)[CH3:23]|US20190389838A1_0307
1.7.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-Br.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[OH:15].[CH3:16][CH2:17][O:18][c:19]1[n:20][n:21][c:22]([s:23]1)[CH:24]([CH3:25])Br>CC(C)=O.O=C(O[K])O[K]>[CH3:16][CH2:17][O:18][c:19]1[n:20][n:21][c:22]([s:23]1)[CH:24]([CH3:25])[O:15][c:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[O:8][c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH3:1]|EP0723546B1_0146
1.8.13|[C:5]-[S&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:16][SH:17].[CH2:18]=[C:19]([CH3:20])[C:21](=[O:22])Cl>CCN(CC)CC.C1CCOC1.O>[CH2:18]=[C:19]([CH3:20])[C:21](=[O:22])[S:17][CH2:16][c:7]1[cH:6][c:5]([c:10]([c:9]([cH:8]1)[C:12]([CH3:13])([CH3:14])[CH3:15])[OH:11])[C:2]([CH3:1])([CH3:3])[CH3:4]|EP0046595A1_0025
2.1.1|[C:5]=[N&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:5]=[N&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][O:2][C:3](=[NH:4])[NH:5][N:6]1[CH2:7][CH2:8][O:9][CH2:10][CH2:11]1.[O:12]=[C:13](Cl)[CH2:14][Cl:15]>CCN(CC)CC.C1CCOC1>[CH3:1][O:2][C:3](=[N:4][C:13](=[O:12])[CH2:14][Cl:15])[NH:5][N:6]1[CH2:7][CH2:8][O:9][CH2:10][CH2:11]1|US20190374542A1_0696
2.1.1|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]1=[C:6]([CH2:7][S:8][C@@H:9]2[CH:10]([C:11]([N:12]12)=[O:13])[NH2:14])[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[O:22]=[C:23](Cl)[CH2:24][O:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>CCN(CC)CC.ClCCl>[CH3:1][O:2][C:3](=[O:4])[C:5]1=[C:6]([CH2:7][S:8][C@@H:9]2[CH:10]([C:11]([N:12]12)=[O:13])[NH:14][C:23](=[O:22])[CH2:24][O:25][c:26]1[cH:31][cH:30][cH:29][cH:28][cH:27]1)[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|EP1781661B1_0293
1.8.13|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][CH:8]([CH3:9])Cl.[SH:10][c:11]1[n:12][n:13][c:14]([s:15]1)[SH:16]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][CH:8]([CH3:9])[S:10][c:11]1[n:12][n:13][c:14]([s:15]1)[SH:16]|US20200039979A1_0310
1.8.13|[C:5]-[S&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])Cl.[O:6]=[C:7]([OH:8])[CH:9]([SH:10])[CH2:11][CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)-[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[Cl:25]>Cl.CCOCC.O=C(O)O[Na].c1ccncc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[S:10][CH:9]([CH2:11][CH2:12][c:13]1[cH:18][cH:17][c:16]([cH:15][cH:14]1)-[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[Cl:25])[C:7](=[O:6])[OH:8]|EP0004320B1_0025
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][OH:2].[NH2:3][c:4]1[n:5][cH:6][c:7]([n:8][c:9]1Br)[Br:10]>[Na]>[CH3:1][O:2][c:9]1[n:8][c:7]([cH:6][n:5][c:4]1[NH2:3])[Br:10]|US20130005707A1_1027
1.8.13|[C&H3&D1:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[OH:1][n:2]1[c:3]([n:4][c:5]2[n:6][c:7]([cH:8][cH:9][c:10]21)Cl)[C:11]([F:12])([F:13])[C:14]([F:15])([F:16])[F:17].[CH3:18][SH:19]>>[CH3:18][S:19][c:7]1[cH:8][cH:9][c:10]2[c:5]([n:4][c:3]([n:2]2[OH:1])[C:11]([F:13])([F:12])[C:14]([F:15])([F:16])[F:17])[n:6]1|US20200347075A1_0313
2.1.1|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[NH2:1][c:2]1[n:3][cH:4][c:5]([cH:6][c:7]1[N+:8]([O-:9])=[O:10])[C:11]([F:12])([F:13])[F:14].[O:15]=[C:16](Cl)[C:17]([F:18])([F:19])[C:20]([F:21])([F:22])[C:23]([F:24])([F:25])[F:26]>>[O-:9][N+:8](=[O:10])[c:7]1[cH:6][c:5]([cH:4][n:3][c:2]1[NH:1][C:16](=[O:15])[C:17]([F:18])([F:19])[C:20]([F:21])([F:22])[C:23]([F:24])([F:25])[F:26])[C:11]([F:12])([F:13])[F:14]|US10202412B2_1104
2.1.2|[N&H3&+&D1:5]-[O:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H1&+0&D2:5](-[O:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[Cl-].[NH3+:1][O:2][CH2:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[F:10].[O:11]=[C:12](O)[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[NH:19][CH2:20][c:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1>>[O:11]=[C:12]([NH:1][O:2][CH2:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[F:10])[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[NH:19][CH2:20][c:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1|US08034811B2_1955
1.6.2|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-Br.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])[O:4][CH2:5][CH2:6][CH2:7][NH:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[NH2:15].[CH3:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH:22]([CH3:23])Br>O.CCO.O=C(O[Na])O[Na]>[CH3:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH:22]([CH3:23])[NH:15][c:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[NH:8][CH2:7][CH2:6][CH2:5][O:4][CH:2]([CH3:1])[CH3:3]|US20060025589A1_0188
1.3.7|[C&H3&D1:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][NH2:2].[F:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[C:10]1=[N:11][CH2:12][c:13]2[cH:14][n:15][c:16]([n:17][c:18]2-[c:19]2[cH:20][cH:21][c:22]([cH:23][c:24]12)[Cl:25])Cl>O.CN(C)C=O>[CH3:1][NH:2][c:16]1[n:15][cH:14][c:13]2[CH2:12][N:11]=[C:10]([c:24]3[cH:23][c:22]([cH:21][cH:20][c:19]3-[c:18]2[n:17]1)[Cl:25])[c:9]1[cH:8][cH:7][cH:6][cH:5][c:4]1[F:3]|US20200181118A1_0946
2.3.9|[C:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][CH2:2][S:3](=[O:4])(=[O:5])[N:6]1[CH2:7][CH2:8][N:9]([C:10]1=[O:11])[C:12](=[O:13])Cl.[NH2:14][CH:15]([C:16](=[O:17])[OH:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25]>C1COCCO1.O[Na].Cl>[CH3:1][CH2:2][S:3](=[O:4])(=[O:5])[N:6]1[CH2:7][CH2:8][N:9]([C:10]1=[O:11])[C:12](=[O:13])[NH:14][CH:15]([C:16](=[O:17])[OH:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25]|US07205292B2_0565
2.1.1|[C:5]=[N&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:5]=[N&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][N:2]1[C:3]([C:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21)([CH3:11])[CH3:12])=[NH:13].[O:14]=[C:15](Cl)[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22]>Cl.c1ccncc1>[CH3:1][N:2]1[C:3]([C:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21)([CH3:11])[CH3:12])=[N:13][C:15](=[O:14])[c:16]1[cH:21][cH:20][c:19]([cH:18][cH:17]1)[Cl:22]|US20140306203A1_0255
1.7.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH:2](Cl)[C:3]#[N:4].[OH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1>O.CC(=O)CC.O=C(O[K])O[K].I[K]>[CH3:1][CH:2]([C:3]#[N:4])[O:5][c:6]1[cH:11][cH:10][cH:9][cH:8][cH:7]1|US20080153850A1_0666
2.1.1|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[S:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[S:1])=[O&H0&D1:3]|[CH3:1][S:2]([NH2:3])(=[O:4])=[O:5].[O:6]=[C:7](Cl)[CH2:8][CH2:9][CH2:10][CH2:11][Br:12]>CCOC(C)=O>[CH3:1][S:2](=[O:4])(=[O:5])[NH:3][C:7](=[O:6])[CH2:8][CH2:9][CH2:10][CH2:11][Br:12]|US20200399243A1_0624
2.6.1|[C:5]-[O&H1&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[O:1]=[C:2](Cl)[N:3]1[CH2:4][CH2:5][NH:6][C:7]1=[O:8].[CH3:9][CH:10]([CH3:11])[OH:12]>C1COCCO1>[CH3:9][CH:10]([CH3:11])[O:12][C:2](=[O:1])[N:3]1[CH2:4][CH2:5][NH:6][C:7]1=[O:8]|US07022707B2_0619
2.2.1|[C:5]-[N&H2&+0&D1:4].[C:3]-[S&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[S&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[NH2:1][C@@H:2]([CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[C:16](=[O:17])[OH:18])[C:19](=[O:20])[OH:21].[O:22]=[S:23](Cl)[C:24]12[CH2:25][CH:26]3[CH2:27][CH:28]([CH2:29][CH:30]([CH2:31]3)[CH2:32]1)[CH2:33]2>CCN1CCOCC1.CN(C)C=O>[O:9]=[C:8]([NH:7][CH2:6][CH2:5][CH2:4][CH2:3][C@H:2]([NH:1][S:23](=[O:22])[C:24]12[CH2:25][CH:26]3[CH2:27][CH:28]([CH2:29][CH:30]([CH2:31]3)[CH2:32]1)[CH2:33]2)[C:19](=[O:20])[OH:21])[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[C:16](=[O:17])[OH:18]|US20170081338A1_0642
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][OH:2].[N:3]#[C:4][c:5]1[c:6]([n:7][c:8]([n:9][c:10]1[Cl:11])Cl)[Cl:12]>>[CH3:1][O:2][c:8]1[n:7][c:6]([c:5]([c:10]([n:9]1)[Cl:11])[C:4]#[N:3])[Cl:12]|EP3193851B1_0410
1.8.13|[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[S&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH:2](Cl)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[Cl:9].[O-:10][n+:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[SH:17].[Na]>>[CH3:1][CH:2]([S:17][c:16]1[cH:15][cH:14][cH:13][cH:12][n+:11]1[O-:10])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[Cl:9]|US08158785B2_0242
2.1.2|[N&H2&+0&D1:5]-[C:4]-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[N&H1&+0&D2:5]1-[C:4]-[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[CH:8]([NH2:9])[CH:10]([C:11](=[O:12])O)[CH:13]([CH3:14])[OH:15]>CC#N.C(=NC1CCCCC1)=NC1CCCCC1>[CH3:14][CH:13]([OH:15])[CH:10]1[C:11]([NH:9][CH:8]1[CH:6]([CH3:7])[C:4](=[O:5])[O:3][CH2:2][CH3:1])=[O:12]|US20070161640A1_0275
3.10.2|[Cl&H0&D1:5]-[C&H2&+0&D2:4]-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[Cl&H0&D1:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[cH:1]1[cH:2][cH:3][c:4]2[CH2:5][CH2:6][c:7]2[cH:8]1.[Cl:9][CH2:10]Cl>Cl[Sn](Cl)(Cl)Cl.COCCl.O>[Cl:9][CH2:10][c:8]1[cH:1][cH:2][cH:3][c:4]2[CH2:5][CH2:6][c:7]12|US08933437B2_0076
1.8.12|[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-Br.[S&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[S&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH:2](Br)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][C:10]([F:11])([F:12])[CH:13]([F:14])[O:15][C:16]([F:17])([F:18])[F:19].[CH3:20][C:21]([CH3:22])([CH3:23])[n:24]1[n:25][cH:26][c:27]([c:28]([c:29]1=[O:30])[Cl:31])[SH:32]>O=C(O[K])O[K].CCOCC.CN(C)C=O>[CH3:20][C:21]([CH3:22])([CH3:23])[n:24]1[n:25][cH:26][c:27]([c:28]([c:29]1=[O:30])[Cl:31])[S:32][CH:2]([CH3:1])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][C:10]([F:11])([F:12])[CH:13]([F:14])[O:15][C:16]([F:18])([F:19])[F:17]|EP3083617B1_0458
2.6.1|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Br.[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[O:8][CH3:9])[OH:10])[O:11][CH3:12].[CH3:13][CH2:14][CH:15]([Br:16])[C:17](=[O:18])Br>CCN(CC)CC.ClCCl>[CH3:9][O:8][c:6]1[cH:7][c:2]([cH:3][c:4]([c:5]1[O:10][C:17](=[O:18])[CH:15]([Br:16])[CH2:14][CH3:13])[O:11][CH3:12])[CH3:1]|US20170362184A1_0197
2.1.8|[C:5]-[N&H2&+0&D1:4].[S&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[S&H0&D1:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[S:9])Cl.[CH3:10][O:11][c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[O:18][CH3:19])[CH2:20][CH2:21][NH2:22]>ClCCl>[CH3:19][O:18][c:17]1[cH:16][cH:15][c:14]([cH:13][c:12]1[O:11][CH3:10])[CH2:20][CH2:21][NH:22][C:8](=[S:9])[c:7]1[cH:6][cH:5][cH:4][cH:3][c:2]1[CH3:1]|EP3088384A1_0220
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[n:6][c:7]([s:8][c:9]1[CH3:10])Br.[CH3:11][OH:12]>[Na]>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[n:6][c:7]([s:8][c:9]1[CH3:10])[O:12][CH3:11]|EP1257555B1_0063
2.6.1|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Br.[C:2]-[O&H1&+0&D1:1]>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[OH:1][CH:2]1[CH2:3][CH2:4][O:5][CH2:6]1.[O:7]=[C:8](Br)[CH2:9][Br:10]>c1ccccc1.c1ccncc1.ClCC1CO1>[O:7]=[C:8]([CH2:9][Br:10])[O:1][CH:2]1[CH2:3][CH2:4][O:5][CH2:6]1|EP3235880A1_0017
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][OH:2].[OH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1Br>O[Na].Cl[Cu]>[CH3:1][O:2][c:9]1[cH:8][cH:7][cH:6][cH:5][c:4]1[OH:3]|EP3221317B1_0656
1.8.13|[O&H0&D1:5]=[C&H0&+0&D3:4](-[O:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[O:3])-[S&H0&+0&D2:2]-[c:1]|[SH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[n:9][c:10]2[CH2:11][CH2:12][CH2:13][n:14]2[c:15]1-[c:16]1[cH:17][cH:18][n:19][cH:20][cH:21]1.[CH3:22][CH2:23][O:24][C:25](=[O:26])Cl>CCN(CC)CC.ClCCl>[CH3:22][CH2:23][O:24][C:25](=[O:26])[S:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[n:9][c:10]2[CH2:11][CH2:12][CH2:13][n:14]2[c:15]1-[c:16]1[cH:17][cH:18][n:19][cH:20][cH:21]1|US06051592A
1.3.6|[C&H3&D1:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][NH2:2].[O:3]=[C:4]([OH:5])[c:6]1[cH:7][n:8][cH:9][c:10]([cH:11]1)Br>O.CCO>[CH3:1][NH:2][c:10]1[cH:9][n:8][cH:7][c:6]([cH:11]1)[C:4](=[O:3])[OH:5]|EP3750897A1_0188
2.6.1|[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[C:13](=[O:14])Cl.[N:15]#[C:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[OH:23]>c1ccccc1.c1ccncc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[C:13](=[O:14])[O:23][c:20]1[cH:19][cH:18][c:17]([cH:22][cH:21]1)[C:16]#[N:15]|US04801603A
2.4.7|[O&H0&D1:5]=[C&H0&+0&D3:4](-[O:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[O:3]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[OH:15].[CH3:16][CH2:17][CH2:18][O:19][C:20](=[O:21])Cl>c1ccccc1.c1ccncc1>[CH3:16][CH2:17][CH2:18][O:19][C:20](=[O:21])[O:15][c:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)-[c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[C:2]#[N:1]|EP2326652B1_0214
1.8.18|[C:5]-[C&H2&+0&D2:4]-[C:3].[c:2]-[S&H0&+0&D2:1]-S-c1:c:c:c:c:c:1>>[C:5]-[C&H1&+0&D3:4](-[C:3])-[S&H0&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[C:10](\[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:18][n:19][cH:20][cH:21][cH:22]1.[cH:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[S:29]Sc1ccccc1>CN(C)P(=O)(N(C)C)N(C)C.CC(C)NC(C)C.CCCCCC.CCCC[Li].O=C(O)O[Na].C1CCOC1.Cl>[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH2:6][CH2:7][CH2:8]/[CH:9]=[C:10](\[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:22][cH:21][cH:20][n:19][cH:18]1)[S:29][c:26]1[cH:27][cH:28][cH:23][cH:24][cH:25]1|US20200165233A1_0371
1.8.13|[N:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[N:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][N:2]([CH3:3])[C:4](=[O:5])Cl.[SH:6][c:7]1[n:8][c:9]([cH:10][nH:11]1)-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>c1ccncc1>[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[S:6][c:7]1[n:8][c:9]([cH:10][nH:11]1)-[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US09000186B2_0566
1.6.2|[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-Br.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[c:3]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[NH2:10].[CH3:11][CH:12](Br)[c:13]1[c:14]([cH:15][cH:16][cH:17][c:18]1[Cl:19])[Cl:20]>>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[NH:10][CH:12]([CH3:11])[c:13]1[c:14]([cH:15][cH:16][cH:17][c:18]1[Cl:19])[Cl:20]|EP3613743A1_0469
1.3.6|[C&H3&D1:5]-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][NH2:2].[NH2:3][c:4]1[n:5][cH:6][c:7]([n:8][c:9]1Br)[Br:10]>CCO>[CH3:1][NH:2][c:9]1[n:8][c:7]([cH:6][n:5][c:4]1[NH2:3])[Br:10]|US20200330458A1_0338
1.7.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-Cl.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH:2](Cl)[C:3](=[O:4])[OH:5].[OH:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>CCOCC.[Na]>[CH3:1][CH:2]([O:6][CH2:7][c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1)[C:3](=[O:4])[OH:5]|US10821115B2_1012
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|O.[CH3:1][OH:2].[Cl:3][c:4]1[cH:5][cH:6][cH:7][c:8]2[s:9][c:10]([n:11][c:12]12)Cl>O.O[Na]>[CH3:1][O:2][c:10]1[n:11][c:12]2[c:4]([cH:5][cH:6][cH:7][c:8]2[s:9]1)[Cl:3]|US10183936B2_0473
1.8.12|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-Br.[C:2]-[S&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[S&H0&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])Br.[SH:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16]>CC(C)=O.O=C(O[K])O[K].I[K]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[S:8][CH2:9][c:10]1[cH:15][cH:14][c:13]([cH:12][cH:11]1)[Cl:16]|US10722481B2_0106
1.8.13|[C&H3&D1:5]-[S&H1&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][SH:2].[O-:3][N+:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1[C:12]([F:13])([F:14])[F:15])Cl>CCO.O[Na]>[CH3:1][S:2][c:9]1[cH:8][cH:7][c:6]([c:11]([cH:10]1)[C:12]([F:13])([F:14])[F:15])[N+:4]([O-:3])=[O:5]|EP0526951A1_0066
2.6.2|[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C:2]-[O&H1&+0&D1:1])-O>>[O&H0&D1:5]=[C&H0&+0&D3:4]1-[O&H0&+0&D2:1]-[C:2]-[C:3]-1|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]([CH2:10][OH:11])[C:12](=[O:13])O>c1ccc(cc1)P(c1ccccc1)c1ccccc1.C1CCOC1.O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@H:9]1[CH2:10][O:11][C:12]1=[O:13]|US05175186A
1.8.13|[C:5]-[S&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:5]-[S&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[N:1]#[C:2][CH2:3][SH:4].[O:5]=[C:6](Cl)[c:7]1[cH:8][cH:9][cH:10][o:11]1>O.CCOCC.c1ccncc1>[N:1]#[C:2][CH2:3][S:4][C:6](=[O:5])[c:7]1[cH:8][cH:9][cH:10][o:11]1|US20180362448A1_0061
1.7.11|[C&H3&D1:5]-[O&H1&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Na+].[CH3:1][OH:2].C[O-].Br[c:3]1[n:4][n:5][c:6]2[CH2:7][c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[CH:14]=[CH:15][n:16]21>CO>[CH3:1][O:2][c:3]1[n:4][n:5][c:6]2[CH2:7][c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[CH:14]=[CH:15][n:16]21|US20130072506A1_0130
1.6.2|[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-Br.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])-[c:3]|[ClH:1].[CH3:2][O:3][c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[O:10][CH3:11])[CH:12]([CH3:13])Br.[NH2:14][CH2:15][CH2:16][CH:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>[Na+].CCCCO.[O-]C(=O)O>[ClH:1].[CH3:11][O:10][c:9]1[cH:8][cH:7][c:6]([cH:5][c:4]1[O:3][CH3:2])[CH:12]([CH3:13])[NH:14][CH2:15][CH2:16][CH:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:29][cH:28][cH:27][cH:26][cH:25]1|US10428051B2_0703
1.7.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-Br.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[OH:11].[CH3:12][CH:13]([CH3:14])[CH:15]([CH3:16])[CH2:17][CH2:18][CH:19]([CH3:20])Br>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:10][cH:9][c:8]([cH:7][cH:6]1)[O:11][CH:19]([CH3:20])[CH2:18][CH2:17][CH:15]([CH3:16])[CH:13]([CH3:14])[CH3:12]|US20050043180A1_0046
1.8.13|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[S&H0&+0&D2:2]-[c:1]|[O:1]=[C:2](Cl)[CH2:3][n:4]1[c:5]([s:6][c:7]2[cH:8][cH:9][c:10]([cH:11][c:12]21)[Cl:13])=[O:14].[SH:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>CC(C)=O.O[K]>[O:14]=[c:5]1[s:6][c:7]2[cH:8][cH:9][c:10]([cH:11][c:12]2[n:4]1[CH2:3][C:2](=[O:1])[S:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[Cl:13]|US09624247B2_0254
1.6.2|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-Br.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:1]-[C:2]|[CH3:1][CH2:2][CH:3]([CH3:4])[NH2:5].[CH3:6][CH2:7][CH2:8][CH:9]([CH3:10])Br>[Na+].CCO.O=S(=O)(O)O.[OH-]>[CH3:6][CH2:7][CH2:8][CH:9]([CH3:10])[NH:5][CH:3]([CH3:4])[CH2:2][CH3:1]|US07368580B2_0037
1.1.7|[C&H3&+0&D1:5]-I.[C&H3&D1:4]-[N&H0&+0&D3:3](-[C:2])-[C:1]>>[C&H3&+0&D1:5]-[N&H0&+&D4:3](-[C&H3&D1:4])(-[C:2])-[C:1]|[CH3:1][NH:2][C:3](=[O:4])[C@@H:5]([NH:6][C:7](=[O:8])[c:9]1[n:10][c:11]([n:12]2[CH2:13][CH2:14][N:15]([CH2:16][c:17]12)[CH3:18])-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[C:25]([CH3:26])([CH3:27])[CH3:28].[CH3:29]I>>[CH3:1][NH:2][C:3](=[O:4])[C@@H:5]([NH:6][C:7](=[O:8])[c:9]1[n:10][c:11]([n:12]2[CH2:13][CH2:14][N+:15]([CH2:16][c:17]12)([CH3:29])[CH3:18])-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[C:25]([CH3:26])([CH3:27])[CH3:28]|EP0284132A2_0082
6.1.3|[C:4]-[C&H1&+0&D3:3](-[C:2])-[N&H1&+0&D2:1]-C(=O)-O-C-c1:c:c:c:c:c:1>>[C:4]-[C@@&H1&+0&D3:3](-[C:2])-[N&H2&+0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[O:7][CH2:8][O:9][C:10](=[O:11])[C@@H:12]1[N:13]2[C:14]([CH:15]([C@H:16]2[S:17]([C:18]1([CH3:19])[CH3:20])(=[O:21])=[O:22])[NH:23]C(=O)OCc1ccccc1)=[O:24]>CCOC(C)=O.[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[O:7][CH2:8][O:9][C:10](=[O:11])[C@@H:12]1[N:13]2[C:14]([C@H:15]([C@H:16]2[S:17]([C:18]1([CH3:19])[CH3:20])(=[O:21])=[O:22])[NH2:23])=[O:24]|US20190307745A1_0172
1.7.9|[C:5]-[O&H1&+0&D1:4].[O:3]-[C&H0&+0&D3:2](=[S&H0&D1:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[O:3])=[S&H0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]([OH:8])[c:9]1[cH:10][cH:11][n:12]([c:13]([cH:14]1)=[O:15])[C:16]1=[CH:17][C:18]([O:19][c:20]2[cH:21][cH:22][c:23]([cH:24][c:25]12)[C:26]#[N:27])([CH3:28])[CH3:29].[S:30]=[C:31](Cl)[O:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1>[Na+].CC#N.CN(C)c1ccncc1.[O-]C(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]([O:8][C:31](=[S:30])[O:32][c:33]1[cH:38][cH:37][cH:36][cH:35][cH:34]1)[c:9]1[cH:10][cH:11][n:12]([c:13]([cH:14]1)=[O:15])[C:16]1=[CH:17][C:18]([O:19][c:20]2[cH:21][cH:22][c:23]([cH:24][c:25]12)[C:26]#[N:27])([CH3:28])[CH3:29]|US20170355712A1_1204
2.1.1|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Br.[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[CH3:1][CH2:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][c:8]([c:9]([c:10]([cH:11]1)[CH3:12])[NH2:13])[CH3:14].[CH3:15][CH:16]([Br:17])[C:18](=[O:19])Br>CC([O-])=O.CC(=O)O.O.O.O.O.[Na+]>[CH3:1][CH2:2][CH2:3][CH2:4][O:5][c:6]1[cH:11][c:10]([c:9]([c:8]([cH:7]1)[CH3:14])[NH:13][C:18](=[O:19])[CH:16]([CH3:15])[Br:17])[CH3:12]|EP3750885A1_0106
2.1.1|[C:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH2:1][CH:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[OH:8].[O:9]=[C:10](Cl)[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[O:17][CH:18]([F:19])[F:20]>>[O:9]=[C:10]([NH:1][CH:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[OH:8])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[O:17][CH:18]([F:19])[F:20]|EP2193125B1_0743
9.7.82|[C&H0&-&D1:5]#[N&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[C-:1]#[N:2].[O:3]=[C:4]1[c:5]2[cH:6][cH:7][cH:8][n:9]2[CH2:10][CH2:11][c:12]2[cH:13][cH:14][c:15]([cH:16][c:17]12)I.[Cu+]>Cl.CN(C)C=O.Cl[Fe](Cl)Cl>[N:2]#[C:1][c:15]1[cH:14][cH:13][c:12]2[CH2:11][CH2:10][n:9]3[cH:8][cH:7][cH:6][c:5]3[C:4]([c:17]2[cH:16]1)=[O:3]|EP3623369A1_0070
1.7.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[n:5]1[n:6][cH:7][c:8]([c:9]([c:10]1=[O:11])[Cl:12])[OH:13].[CH3:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[CH:21]([CH3:22])Cl>O=C(O[K])O[K].CN(C)C=O.O>[CH3:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[CH:21]([CH3:22])[O:13][c:8]1[cH:7][n:6][n:5]([c:10]([c:9]1[Cl:12])=[O:11])[C:2]([CH3:1])([CH3:3])[CH3:4]|US20090281086A1_0227
2.1.11|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[N:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N:1])=[O&H0&D1:3]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8](=[O:9])Cl.[NH2:10][NH:11][C:12](=[O:13])[N:14]1[CH2:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[O:22][c:23]2[cH:24][cH:25][c:26]([cH:27][c:28]21)[Cl:29]>O=C(O)O[Na]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8](=[O:9])[NH:10][NH:11][C:12](=[O:13])[N:14]1[CH2:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[O:22][c:23]2[cH:24][cH:25][c:26]([cH:27][c:28]21)[Cl:29]|US06887863B2_0146
2.1.41|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[O:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[O:1])=[O&H0&D1:3]|[CH3:1][O:2][NH2:3].[O:4]=[C:5]([O:6][CH:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[CH:20]1[C:21](=[CH:22][S:23][C@@H:24]2[CH:25]([C:26]([N:27]21)=[O:28])[NH:29][C:30](=[O:31])[CH2:32][c:33]1[cH:34][cH:35][cH:36][s:37]1)[C:38](=[O:39])Cl>C1CCOC1>[CH3:1][O:2][NH:3][C:38](=[O:39])[C:21]1=[CH:22][S:23][C@@H:24]2[CH:25]([C:26]([N:27]2[CH:20]1[C:5](=[O:4])[O:6][CH:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)=[O:28])[NH:29][C:30](=[O:31])[CH2:32][c:33]1[cH:34][cH:35][cH:36][s:37]1|EP1458394B1_0088
2.6.1|[N:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[N:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][N:2]([CH3:3])[C:4](=[O:5])Cl.[OH:6][c:7]1[cH:8][cH:9][cH:10][c:11]2[n:12][s:13][cH:14][c:15]21>O.CN(C)C=O.[H][H].[NaH]>[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[O:6][c:7]1[cH:8][cH:9][cH:10][c:11]2[n:12][s:13][cH:14][c:15]21|US07067517B2_1944
2.1.8|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[S&H0&D1:1])-Cl>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[S&H0&D1:1]|[N:1]#[C:2][CH2:3][CH2:4][C:5](=[S:6])Cl.[NH2:7][CH:8]1[C:9]([N:10]2[C:11](=[C:12]([CH2:13][S:14][C@H:15]12)[OH:16])[C:17](=[O:18])[O:19][CH2:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[N+:27]([O-:28])=[O:29])=[O:30]>>[N:1]#[C:2][CH2:3][CH2:4][C:5](=[S:6])[NH:7][CH:8]1[C:9]([N:10]2[C:11](=[C:12]([CH2:13][S:14][C@H:15]12)[OH:16])[C:17](=[O:18])[O:19][CH2:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[N+:27]([O-:28])=[O:29])=[O:30]|US05817599A
2.6.2|[C&H3&D1:5]-[C&H1&+0&D3:4](-[O:3])-Br.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[O:3]|[CH3:1][O:2]/[N:3]=[C:4](\[C:5](=[O:6])[NH:7][C@@H:8]1[C:9]([N:10]2[C:11](=[C:12]([CH2:13][S:14][C@H:15]12)[CH2:16][O:17][C:18]([NH2:19])=[O:20])[C:21](=[O:22])[OH:23])=[O:24])[c:25]1[cH:26][cH:27][cH:28][o:29]1.[CH3:30][C:31](=[O:32])[O:33][CH:34]([CH3:35])Br>Cl.CCOC(C)=O.CN(C)C=O.O=C(O[K])O[K]>[CH3:1][O:2]/[N:3]=[C:4](\[C:5](=[O:6])[NH:7][C@@H:8]1[C:9]([N:10]2[C:11](=[C:12]([CH2:13][S:14][C@H:15]12)[CH2:16][O:17][C:18]([NH2:19])=[O:20])[C:21](=[O:22])[O:23][CH:34]([CH3:35])[O:33][C:31]([CH3:30])=[O:32])=[O:24])[c:25]1[cH:26][cH:27][cH:28][o:29]1|US20180291039A1_1167
2.4.7|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][O:2][C:3](=[O:4])Cl.[O:5]=[C:6]([OH:7])[CH:8]([OH:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>CN(C)c1ccccc1.C1CCOC1>[CH3:1][O:2][C:3](=[O:4])[O:9][CH:8]([C:6](=[O:5])[OH:7])[c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|EP3590927A1_0218
1.3.9|[C:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]([CH3:3])[CH:4]=[C:5]1[C:6]([NH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]12)=[O:14].[CH3:15][O:16][c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)I>O.CCCCCC.CCOCC.CN(C)C=O.[NaH]>[CH3:15][O:16][c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)[N:7]1[C:6]([C:5]([c:13]2[cH:12][cH:11][cH:10][cH:9][c:8]21)=[CH:4][N:2]([CH3:1])[CH3:3])=[O:14]|EP3030565B1_0097
1.3.6|[C:6]-[N&H2&+&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-]C(=O)C([O-])=O.[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)Br.[CH2:10]1[O:11][CH2:12][C:13]11[CH2:14][NH2+:15][CH2:16]1>>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[N:15]1[CH2:14][C:13]2([CH2:10][O:11][CH2:12]2)[CH2:16]1|US10414775B2_0459
1.3.9|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-I>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][NH:6]1.I[c:7]1[cH:8][cH:9][cH:10][s:11]1>CCCCCCCCCCCC.N[C@@H]1CCCC[C@H]1N.C1COCCO1.[O-]P([O-])([O-])=O.I[Cu].[K+].[K+].[K+]>[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][N:6]1[c:7]1[cH:8][cH:9][cH:10][s:11]1|US20190276465A1_0270
1.2.9|[C:6]-[C&H1&+0&D3:5](-[C:4])-O.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[c:6]1[cH:7][cH:8][cH:9][c:10]2[n:11][c:12]([n:13]([c:14]12)[CH2:15][CH:16](O)[CH2:17][C:18](=[O:19])[O:20][CH3:21])[NH:22][c:23]1[cH:24][cH:25][c:26]([cH:27][c:28]1[Cl:29])[Cl:30]>[Na+].CCOC(C)=O.CS(=O)(=O)Cl.[O-]C(=O)O.O=C(O[K])O[K].c1ccncc1>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[c:6]1[cH:7][cH:8][cH:9][c:10]2[n:11][c:12]3[N:22]([CH:16]([CH2:15][n:13]3[c:14]12)[CH2:17][C:18](=[O:19])[O:20][CH3:21])[c:23]1[cH:24][cH:25][c:26]([cH:27][c:28]1[Cl:29])[Cl:30]|US10759790B2_0443
1.7.12|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[S:3].[C:2]-[O&H1&+0&D1:1]>>[C&H2&+0&D2:5](-[O&H0&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[S:3]|[CH2:1]=[CH:2][S:3]([CH3:4])(=[O:5])=[O:6].[CH3:7][CH2:8][O:9][CH2:10][c:11]1[n:12][c:13]2[cH:14][n:15][c:16]3[cH:17][c:18]([cH:19][cH:20][c:21]3[c:22]2[n:23]1[CH2:24][C:25]([CH3:26])([CH3:27])[OH:28])[Br:29]>O.C1CCOC1.[NaH]>[CH3:7][CH2:8][O:9][CH2:10][c:11]1[n:12][c:13]2[cH:14][n:15][c:16]3[cH:17][c:18]([cH:19][cH:20][c:21]3[c:22]2[n:23]1[CH2:24][C:25]([CH3:26])([CH3:27])[O:28][CH2:1][CH2:2][S:3]([CH3:4])(=[O:5])=[O:6])[Br:29]|US20160339117A1_1385
1.3.8|[C:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[CH:9]([C:10]#[N:11])[NH:12][C:13](=[O:14])[C@H:15]([CH2:16][CH:17]([CH3:18])[CH3:19])[NH:20][c:21]1[cH:22][cH:23][n:24][c:25]([n:26]1)F.[CH2:27]1[CH2:28][NH:29][CH2:30][CH2:31][O:32]1>CC(C)N(CC)C(C)C.CCOC(C)=O.CCCC(C)C.C1CCOC1>[CH3:18][CH:17]([CH3:19])[CH2:16][C@H:15]([NH:20][c:21]1[cH:22][cH:23][n:24][c:25]([n:26]1)[N:29]1[CH2:30][CH2:31][O:32][CH2:27][CH2:28]1)[C:13](=[O:14])[NH:12][CH:9]([C:10]#[N:11])[c:8]1[cH:7][cH:6][cH:5][cH:4][c:3]1[O:2][CH3:1]|EP2467142B1_0342
2.1.2|[N&H2&+0&D1:5]-[O:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H1&+0&D2:5](-[O:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](O)[c:3]1[cH:4][n:5][n:6]([c:7]1[Br:8])-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH3:15][O:16][NH2:17].Cl>O=C(n1cncc1)n1cncc1.CCN(CC)CC.CN(C)C=O.O>[CH3:15][O:16][NH:17][C:2](=[O:1])[c:3]1[cH:4][n:5][n:6]([c:7]1[Br:8])-[c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1|EP2130536B1_0246
3.11.86|[C:6]-[C&H2&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[O:9][CH2:10][CH3:11].[Br:12][c:13]1[cH:14][cH:15][c:16]([n:17][cH:18]1)I>O=C(O)C(CCCCl)c1ccc(cn1)Br.[Cu]>[CH3:11][CH2:10][O:9][C:7](=[O:8])[CH:6]([C:4](=[O:5])[O:3][CH2:2][CH3:1])[c:16]1[cH:15][cH:14][c:13]([cH:18][n:17]1)[Br:12]|US10494376B2_0641
1.3.8|[C:6]-[N&H1&+0&D2:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:6]-[N&H0&+0&D3:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]1[CH2:3][CH2:4][NH:5][S:6]1(=[O:7])=[O:8].[O-:9][N+:10](=[O:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)F>O.CN(C)C=O.[NaH]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([S:6]1(=[O:7])=[O:8])[c:15]1[cH:16][cH:17][c:12]([cH:13][cH:14]1)[N+:10]([O-:9])=[O:11]|US10174024B2_0494
2.4.8|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O-C>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][O:2][C:3](=[O:4])OC.[CH3:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][OH:12]>[Na+].C[O-]>[CH3:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][O:12][C:3](=[O:4])[O:2][CH3:1]|US09062028B2_0770
1.2.9|[C:6]-[C&H1&+0&D3:5](-[c:4])-O.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[C:11](=[O:12])[N:13]1[CH2:14][CH2:15][CH:16]([c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]21)O.[cH:23]1[cH:24][cH:25][c:26]2[CH2:27][CH2:28][NH:29][c:30]2[cH:31]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[C:11](=[O:12])[N:13]1[CH2:14][CH2:15][CH:16]([c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]21)[N:29]1[CH2:28][CH2:27][c:26]2[cH:25][cH:24][cH:23][cH:31][c:30]21|US07687529B2_0422
1.3.8|[c:6]:[c&H0&+0&D3:5](:[n:4])-F.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|F[c:1]1[cH:2][cH:3][cH:4][c:5]([n:6]1)[O:7][c:8]1[cH:9][s:10][c:11]([cH:12]1)[C:13]([F:14])([F:15])[F:16].[F:17][C:18]([F:19])([F:20])[c:21]1[cH:22][n:23][nH:24][cH:25]1>CC(=O)N(C)C.O.[Na+].[H-]>[F:14][C:13]([F:15])([F:16])[c:11]1[cH:12][c:8]([cH:9][s:10]1)[O:7][c:5]1[cH:4][cH:3][cH:2][c:1]([n:6]1)-[n:24]1[cH:25][c:21]([cH:22][n:23]1)[C:18]([F:17])([F:19])[F:20]|US20110076230A1_0084
2.5.5|[C:5]-[N&H2&+0&D1:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[N&H1&+0&D1:3])-[c:1]|[ClH:1].[CH3:2][CH2:3][NH2:4].[N:5]#[C:6][c:7]1[cH:8][cH:9][c:10]([cH:11][n:12]1)[C:13](=[O:14])[OH:15]>CO.[Na]>[ClH:1].[CH3:2][CH2:3][NH:4][C:6](=[NH:5])[c:7]1[cH:8][cH:9][c:10]([cH:11][n:12]1)[C:13](=[O:14])[OH:15]|US20200308156A1_0290
7.6.1|[C:6]-[C&H0&+0&D3:5](-[S:4])=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[C:6]-[C&H1&+0&D3:5](-[S:4])-[C&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][CH2:2][CH2:3][C:4]([C:5](=[O:6])[OH:7])=[C:8]1[S:9][CH2:10][C@H:11]2[C@@H:12]1[N:13]([C:14]([N:15]2[C@H:16]([CH3:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)=[O:24])[CH2:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>CC(C)O.[Pd]>[CH3:1][CH2:2][CH2:3][CH:4]([C:5](=[O:6])[OH:7])[CH:8]1[S:9][CH2:10][C@H:11]2[C@@H:12]1[N:13]([C:14]([N:15]2[C@H:16]([CH3:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)=[O:24])[CH2:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1|US07094905B2_0036
1.3.9|[c:6]:[c&H0&+0&D3:5](:[c:4])-I.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[n:3][nH:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]12)[N+:11]([O-:12])=[O:13].[O:14]=[C:15]([OH:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1I>O=C(O[K])O[K].[O-2].[Cu+2]>[CH3:1][c:2]1[n:3][n:4]([c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]12)[N+:11]([O-:12])=[O:13])-[c:22]1[cH:21][cH:20][cH:19][cH:18][c:17]1[C:15](=[O:14])[OH:16]|US08314094B2_0857
2.1.3|[N&H2&+0&D1:5]-[n:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H1&+0&D2:5](-[n:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[n:6][cH:7][n:8]([c:9]2[cH:10][c:11]1[O:12][CH3:13])-[c:14]1[n:15][c:16]([c:17]([s:18]1)[C:19](=[O:20])O)-[c:21]1[cH:22][cH:23][cH:24][c:25]([cH:26]1)[Cl:27].[NH2:28][n:29]1[cH:30][n:31][n:32][cH:33]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[n:6][cH:7][n:8]([c:9]2[cH:10][c:11]1[O:12][CH3:13])-[c:14]1[n:15][c:16]([c:17]([s:18]1)[C:19](=[O:20])[NH:28][n:29]1[cH:30][n:31][n:32][cH:33]1)-[c:21]1[cH:22][cH:23][cH:24][c:25]([cH:26]1)[Cl:27]|EP2142516B1_0553
1.7.12|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[C:2]-[O&H1&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:1]-[C:2]|[CH2:1]=[CH:2][CH2:3][CH3:4].CCCC.[CH3:5][CH2:6][CH:7]([CH3:8])[OH:9]>O>[CH3:5][CH2:6][CH:7]([CH3:8])[O:9][CH:2]([CH3:1])[CH2:3][CH3:4]|US08722944B2_0073
1.3.9|[c:6]:[c&H0&+0&D3:5](:[n:4])-I.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[c:3]([c:4]([n:5][n:6]1[CH2:7][C:8](=[O:9])[N:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[c:16]1[cH:17][cH:18][c:19]([c:20]([cH:21]1)[O:22][CH3:23])[Cl:24])I)[Cl:25].[cH:26]1[cH:27][nH:28][n:29][n:30]1>CO.CCOC(C)=O.CS(C)=O.[O-]C([O-])=O.Oc1cccc2cccnc21.I[Cu].[K+].[K+]>[CH3:23][O:22][c:20]1[cH:21][c:16]([cH:17][cH:18][c:19]1[Cl:24])[N:13]1[CH2:14][CH2:15][N:10]([CH2:11][CH2:12]1)[C:8](=[O:9])[CH2:7][n:6]1[n:5][c:4]([c:3]([c:2]1[CH3:1])[Cl:25])-[n:28]1[cH:27][cH:26][n:30][n:29]1|EP2751106B1_0404
2.1.37|[N&H1&+0&D1:5]=[S:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H0&+0&D2:5](=[S:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](O)[c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[Cl:9])[O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[Cl:17])[C:18]([F:19])([F:20])[F:21].[CH3:22][S:23]([CH3:24])(=[NH:25])=[O:26]>C(=NC1CCCCC1)=NC1CCCCC1.ClCCl>[CH3:22][S:23]([CH3:24])(=[O:26])=[N:25][C:2](=[O:1])[c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[Cl:9])[O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[Cl:17])[C:18]([F:19])([F:20])[F:21]|US20200354326A1_0260
1.2.9|[C:6]-[C&H1&+0&D3:5](-[C:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]2[nH:7][cH:8][c:9]([c:10]12)[I:11].[CH3:12][N:13]1[CH2:14][CH:15]2[CH2:16][CH:17]([CH2:18][CH:19]2[CH2:20]1)O>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)N=NC(=O)OCC.C1CCOC1>[CH3:12][N:13]1[CH2:20][CH:19]2[CH2:18][CH:17]([CH2:16][CH:15]2[CH2:14]1)[n:7]1[cH:8][c:9]([c:10]2[c:2]([n:3][cH:4][n:5][c:6]21)[Cl:1])[I:11]|US20200317686A1_0393
3.11.34|[C:6]-[C&H2&+0&D2:5]-[c:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=O)[CH2:12][O:13][C:14](=[O:15])[CH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23]>Cc1ccc(cc1)S(=O)(=O)O.CCN(CC)CC.CC#N>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11]1[CH2:12][O:13][C:14]([C:16]=1[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23])=[O:15]|US07105562B2_0312
2.1.37|[N&H1&+0&D1:5]=[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H0&+0&D2:5](=[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH:1]=[c:2]1[s:3][cH:4][n:5][n:6]1[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[O:14]=[C:15](O)[c:16]1[cH:17][n:18][cH:19][cH:20][c:21]1[C:22]([F:23])([F:24])[F:25].Br>CN(C)C=O.C(C#[O+])#[O+].ClCCl.[Cl-].[Cl-]>[O:14]=[C:15]([N:1]=[c:2]1[s:3][cH:4][n:5][n:6]1[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:16]1[cH:17][n:18][cH:19][cH:20][c:21]1[C:22]([F:23])([F:24])[F:25]|US20150011528A1_0878
2.1.2|[N&H2&+0&D1:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[N+:8]([O-:9])=[O:10])[NH2:11].[CH3:12][C:13]([CH3:14])([CH3:15])[O:16][C:17](=[O:18])O>C1CCOC1>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[N+:8]([O-:9])=[O:10])[NH:11][C:17](=[O:18])[O:16][C:13]([CH3:12])([CH3:14])[CH3:15]|US09173883B2_0375
10.4.3|[O&H2&+0&D0:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[O:1]>>[O&H1&+0&D1:5]-[C&H1&+0&D3:3](-[C:4])-[C&H2&+0&D2:2]-[O:1]|[CH3:1][O:2][CH:3]1[CH2:4][CH2:5][CH:6]=[CH:7][O:8]1.[OH2:9]>C1CCOC1.C1CCOC1.B>[CH3:1][O:2][CH:3]1[CH2:4][CH2:5][CH:6]([CH2:7][O:8]1)[OH:9]|US20120022045A1_0744
1.3.8|[C:6]-[N&H1&+0&D2:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C:6]-[N&H0&+0&D3:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[S:11](=[O:12])(=[O:13])[NH:14][CH2:15][c:16]1[cH:17][cH:18][c:19]2[o:20][cH:21][cH:22][c:23]2[cH:24]1.F[c:25]1[n:26][cH:27][c:28]([cH:29][c:30]1[Cl:31])[Cl:32]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[S:11](=[O:12])(=[O:13])[N:14]([CH2:15][c:16]1[cH:17][cH:18][c:19]2[o:20][cH:21][cH:22][c:23]2[cH:24]1)[c:25]1[n:26][cH:27][c:28]([cH:29][c:30]1[Cl:31])[Cl:32]|US08829026B2_0544
2.5.7|[C:5]-[N&H2&+0&D1:4].[N&H2&D1:3]-[C&H0&+0&D3:2](=[N:1])-S-C>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N&H2&D1:3])=[N:1]|I.[CH3:1][CH2:2][CH2:3][CH2:4][NH2:5].[CH3:6][C:7](=[O:8])[NH:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][c:15]([n:16]1)-[c:17]1[cH:18][s:19][c:20]([n:21]1)[N:22]=[C:23]([NH2:24])SC>CCO>[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][C:23]([NH2:24])=[N:22][c:20]1[n:21][c:17]([cH:18][s:19]1)-[c:15]1[cH:14][cH:13][cH:12][c:11]([n:16]1)[CH2:10][NH:9][C:7]([CH3:6])=[O:8]|US05364871A
1.3.9|[C:6]-[N&H1&+0&D2:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]-[N&H0&+0&D3:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][NH:3][S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH3:13].I[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>CN[C@@H]1CCCC[C@H]1NC.Cc1ccccc1.[O-]C([O-])=O.I[Cu].[K+].[K+]>[CH3:13][c:10]1[cH:11][cH:12][c:7]([cH:8][cH:9]1)[S:4](=[O:5])(=[O:6])[N:3]([CH2:2][CH3:1])[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|EP3383179B1_0228
1.2.9|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|O.[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)[OH:8])O.[CH3:9][CH2:10][CH2:11][CH2:12][NH:13][CH2:14][CH2:15][CH2:16][CH3:17]>>[CH3:9][CH2:10][CH2:11][CH2:12][N:13]([CH2:14][CH2:15][CH2:16][CH3:17])[c:4]1[cH:5][c:6]([cH:7][c:2]([cH:3]1)[CH3:1])[OH:8]|US20200113879A1_1078
1.6.8|[C:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-I>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][C@H:5]1[CH2:6][S:7][C:8]([NH:9]1)=[N:10][c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[CH3:17])[N+:18]([O-:19])=[O:20].[CH3:21][CH2:22][CH2:23][CH2:24][CH:25](I)[CH2:26][CH3:27]>>[CH3:21][CH2:22][CH2:23][CH2:24][CH:25]([CH2:26][CH3:27])[N:9]1[C:8]([S:7][CH2:6][C@@H:5]1[CH2:4][CH:2]([CH3:1])[CH3:3])=[N:10][c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[CH3:17])[N+:18]([O-:19])=[O:20]|EP2491022B1_0186
1.2.5|[C:6]-[N&H1&+0&D2:5]-[c:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[C:11]1([CH2:12][CH2:13][C:14]([CH2:15][CH2:16]1)=O)[C:17]#[N:18].[CH3:19][O:20][c:21]1[cH:22][c:23]2[CH2:24][CH2:25][CH2:26][NH:27][c:28]2[cH:29][c:30]1[O:31][CH3:32].[ClH:33]>CCN(CC)CC.CC(C)O.N#C[BH3-].[Na+]>[CH3:10][O:9][c:8]1[cH:7][cH:6][c:5]([cH:4][c:3]1[O:2][CH3:1])[C:11]1([CH2:12][CH2:13][CH:14]([CH2:15][CH2:16]1)[N:27]1[CH2:26][CH2:25][CH2:24][c:23]2[cH:22][c:21]([c:30]([cH:29][c:28]21)[O:31][CH3:32])[O:20][CH3:19])[C:17]#[N:18].[ClH:33]|US10118926B2_0886
1.3.9|[c:6]:[c&H0&+0&D3:5](:[c:4])-I.[n:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[n:3]):[n:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1I.[cH:10]1[cH:11][n:12][nH:13][n:14]1>CN[C@H]1CCCC[C@@H]1NC.CN(C)C=O.I[Cu]>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1-[n:13]1[n:14][cH:10][cH:11][n:12]1|US20200102311A1_0608
1.3.8|[C:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][NH:3][c:4]1[n:5][cH:6][cH:7][cH:8][c:9]1-[c:10]1[cH:11][s:12][cH:13][c:14]1-[c:15]1[cH:16][cH:17][cH:18][n:19][c:20]1F>C[Si](C)(C)[N-][Si](C)(C)C.CCOC(C)=O.C1CCOC1.CCO.[K+]>[CH3:1][CH2:2][N:3]1[c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2-[c:10]2[cH:11][s:12][cH:13][c:14]2-[c:15]2[cH:16][cH:17][cH:18][n:19][c:20]21|US20060161001A1_0319
1.1.5|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[N&H0&+0&D3:3](-[C:2])-[C:1]>>[C:6]-[C&H2&+0&D2:5]-[N&H0&+&D4:3](-[C:4])(-[C:2])-[C:1]|[O:1]=[C:2]([O:3][C@H:4]1[CH2:5][N:6]2[CH2:7][CH2:8][CH:9]1[CH2:10][CH2:11]2)[C@H:12]([NH:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[O:26]=[C:27]([CH2:28]Br)[c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[O:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1>CCOC(C)=O>[O:1]=[C:2]([O:3][C@H:4]1[CH2:5][N+:6]2([CH2:7][CH2:8][CH:9]1[CH2:10][CH2:11]2)[CH2:28][C:27](=[O:26])[c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[O:35][c:36]1[cH:41][cH:40][cH:39][cH:38][cH:37]1)[C@H:12]([NH:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|
7.6.1|[C:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][CH2:2][C:3](=[C:4]([c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH2:12][CH3:13])[C:14]([F:15])([F:16])[F:17])[c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[O:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>CCOc1ccc(cc1)C(CCCc1cccc(c1)Oc1ccccc1)C(F)(F)F.CCO.[Pd]>[CH3:1][CH2:2][CH:3]([c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[O:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[CH:4]([c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH2:12][CH3:13])[C:14]([F:15])([F:16])[F:17]|US20090099250A1_0391
3.11.91|[C&H3&+0&D1:5]-I.[C&H3&D1:4]-[C&H1&+0&D3:3](-[C:2])-[O:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[O:8][c:9]1[cH:10][c:11]([cH:12][c:13]2[c:14]1[O:15][CH:16]1[CH2:17][CH:18]=[CH:19][CH:20]21)[Br:21].[CH3:22]I>CN(C)P(=O)(N(C)C)N(C)C.CC(C)NC(C)C.CCCC[Li].C1CCOC1.[NH4+].[Cl-]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:22])([CH3:7])[O:8][c:9]1[cH:10][c:11]([cH:12][c:13]2[c:14]1[O:15][CH:16]1[CH2:17][CH:18]=[CH:19][CH:20]21)[Br:21]|US08188079B2_0657
3.11.86|[C:6]-[C&H2&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][c:9]([c:10]([n:11]1[CH3:12])[C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[CH3:21].[O-:22][N+:23](=[O:24])[c:25]1[cH:26][cH:27][c:28]([c:29]([cH:30]1)[F:31])F>O.Cl.CN(C)C=O.[NaH]>[CH3:21][c:9]1[cH:8][c:7]([n:11]([c:10]1[C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[CH3:12])[CH:6]([C:4](=[O:5])[O:3][CH2:2][CH3:1])[c:28]1[cH:27][cH:26][c:25]([cH:30][c:29]1[F:31])[N+:23]([O-:22])=[O:24]|US08263606B2_1496
1.2.9|[c:6]:[c&H0&+0&D3:5](:[c:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][C:6]([CH3:7])([CH3:8])[c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)O)[O:15][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][O:21]1.[CH3:22][C:23]([CH3:24])([CH3:25])[c:26]1[cH:27][cH:28][c:29]2[nH:30][c:31]3[cH:32][cH:33][c:34]([cH:35][c:36]3[c:37]2[cH:38]1)[C:39]([CH3:40])([CH3:41])[CH3:42]>O=P(O[K])(O[K])O[K].CNCCNC>[CH3:40][C:39]([CH3:41])([CH3:42])[c:34]1[cH:33][cH:32][c:31]2[c:36]([cH:35]1)[c:37]1[cH:38][c:26]([cH:27][cH:28][c:29]1[n:30]2-[c:13]1[cH:14][c:9]([cH:10][cH:11][c:12]1[O:15][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][O:21]1)[C:6]([CH3:7])([CH3:8])[CH2:5][C:2]([CH3:1])([CH3:3])[CH3:4])[C:23]([CH3:22])([CH3:24])[CH3:25]|US08258134B2_1055
9.5.4|[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H0&+0&D4:3](-[C:2])(-[c:1])-O>>[C&H3&D1:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]|[CH3:1][CH2:2][C:3](O)([CH2:4][CH3:5])[c:6]1[n:7][c:8]([n:9][c:10]2[c:11]1[c:12]([c:13]([n:14]2-[c:15]1[c:16]([cH:17][c:18]([cH:19][c:20]1[CH3:21])[CH3:22])[CH3:23])[CH3:24])[CH3:25])[CH3:26]>O.[Na+].CC(=O)O.Cc1ccc(cc1)COC(=O)NNC(=O)c1cnccn1.O=S(=O)(O)O.[OH-]>[CH3:5][CH2:4][C:3](=[CH:2][CH3:1])[c:6]1[n:7][c:8]([n:9][c:10]2[c:11]1[c:12]([c:13]([n:14]2-[c:15]1[c:16]([cH:17][c:18]([cH:19][c:20]1[CH3:21])[CH3:22])[CH3:23])[CH3:24])[CH3:25])[CH3:26]|US20060004195A1_0916
3.11.31|[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&+:3].[c:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:5]/[C&H0&+0&D3:4](-[N&+:3])=[C&H1&+0&D2:1]\[c:2]|[CH3:1][O:2][CH2:3][O:4][CH2:5][CH2:6][c:7]1[cH:8][c:9]([c:10]([cH:11][c:12]1[O:13][CH3:14])[CH:15]=O)[O:16][CH3:17].[CH3:18][CH2:19][N+:20]([O-:21])=[O:22]>[NH4+].CC([O-])=O>[CH3:1][O:2][CH2:3][O:4][CH2:5][CH2:6][c:7]1[cH:8][c:9]([c:10]([cH:11][c:12]1[O:13][CH3:14])/[CH:15]=[C:19](\[CH3:18])[N+:20]([O-:21])=[O:22])[O:16][CH3:17]|US20200216394A1_0421
3.11.86|[C:6]-[C&H2&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][C:6]#[N:7].[O-:8][N+:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1F>O.[Na+].[Cl-].CN(C)C=O.[NaH]>[CH3:1][O:2][C:3](=[O:4])[CH:5]([C:6]#[N:7])[c:16]1[cH:15][cH:14][cH:13][cH:12][c:11]1[N+:9]([O-:8])=[O:10]|EP3738960A1_1710
1.3.8|[c:6]:[c&H0&+0&D3:5](:[c:4])-F.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:9][c:10]1[cH:11][n:12][cH:13][n:14][cH:15]1.[N:16]#[C:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)F>>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[N:9]([c:21]1[cH:22][cH:23][c:18]([cH:19][cH:20]1)[C:17]#[N:16])[c:10]1[cH:11][n:12][cH:13][n:14][cH:15]1|EP1817806B1_0219
3.11.86|[C:6]-[C&H2&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][c:6]1[n:7][c:8]([c:9]([cH:10][c:11]1[F:12])[C:13]#[N:14])F.[CH3:15][O:16][C:17](=[O:18])[CH2:19][C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26].[Na]>C1COCCO1.CCOCC>[CH3:24][C:23]([CH3:25])([CH3:26])[O:22][C:20](=[O:21])[CH:19]([C:17](=[O:18])[O:16][CH3:15])[c:8]1[n:7][c:6]([c:11]([cH:10][c:9]1[C:13]#[N:14])[F:12])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20130035326A1_1495
2.5.5|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[C:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:2](-[C:3])-[N&H2&+0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH2:7][CH2:8][C:9]#[N:10])=[C:11]([NH2:12])[NH2:13]>O.C1CCOC1.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1[CH2:7][CH2:8][C:9](=[N:13][C:11]=1[NH2:12])[NH2:10]|EP3204391B1_0188
1.3.8|[c:6]:[c&H0&+0&D3:5](:[n:4])-F.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][s:9][c:10]([n:11]1)[NH:12][C:13](=[O:14])[CH2:15][N:16]([CH3:17])[c:18]1[n:19][cH:20][cH:21][c:22]([n:23]1)F.[CH3:24][S:25][c:26]1[n:27][c:28]([nH:29][cH:30][c:31]1[CH:32]1[c:33]2[cH:34][cH:35][c:36]([cH:37][c:38]2[CH:39]=[CH:40][c:41]2[c:42]1[cH:43][cH:44][c:45]([cH:46]2)[CH3:47])[CH2:48][CH3:49])=[O:50]>CN1CCCC1=O.O=C(O[Cs])O[Cs]>[CH3:49][CH2:48][c:36]1[cH:35][cH:34][c:33]2[c:38]([cH:37]1)[CH:39]=[CH:40][c:41]1[cH:46][c:45]([cH:44][cH:43][c:42]1[CH:32]2[c:31]1[cH:30][n:29]([c:28]([n:27][c:26]1[S:25][CH3:24])=[O:50])-[c:22]1[cH:21][cH:20][n:19][c:18]([n:23]1)[N:16]([CH3:17])[CH2:15][C:13](=[O:14])[NH:12][c:10]1[n:11][c:7]([cH:8][s:9]1)[CH2:6][C:4](=[O:5])[O:3][CH2:2][CH3:1])[CH3:47]|US20200262784A1_0413
2.4.10|[C:5]-[O&H1&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][CH:2]([CH3:3])[C@H:4]([CH2:5][OH:6])[NH:7][C:8](=[O:9])OC>Cc1ccccc1>[CH3:1][CH:2]([CH3:3])[C@@H:4]1[CH2:5][O:6][C:8]([NH:7]1)=[O:9]|US09481682B2_0861
1.2.17|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[N&H2&+0&D1:2]-[c:1]>>[C&H3&+0&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[C:8]([F:9])([F:10])[F:11].[CH2:12]=[CH:13][C:14]#[N:15].Cl>CCNCC.O[Na]>[CH3:12][CH:13]([C:14]#[N:15])[NH:1][c:2]1[cH:7][c:6]([cH:5][cH:4][cH:3]1)[C:8]([F:9])([F:10])[F:11]|US05231184A
1.2.9|[C:6]-[C&H1&+0&D3:5](-[C:4])-O.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[O:1]=[C:2]1[NH:3][c:4]2[n:5][c:6]([n:7][cH:8][c:9]2[CH2:10][N:11]1[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18])[S:19](=[O:20])(=[O:21])[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[CH3:29][N:30]1[CH2:31][CH2:32][CH:33]([CH2:34][CH2:35]1)O>c1ccc(cc1)P(c1ccccc1)c1ccccn1.CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.C1CCOC1>[CH3:29][N:30]1[CH2:31][CH2:32][CH:33]([CH2:34][CH2:35]1)[N:3]1[C:2]([N:11]([CH2:10][c:9]2[c:4]1[n:5][c:6]([n:7][cH:8]2)[S:19](=[O:20])(=[O:21])[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18])=[O:1]|US07223859B2_0181
1.3.9|[C:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][CH2:8][n:9]1[cH:10][c:11]([n:12][c:13]1I)-[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[C:20]([F:21])([F:22])[F:23].[CH2:24]1[CH2:25][NH:26][CH2:27][CH2:28][NH:29]1>ClC(Cl)(Cl)C(Cl)(Cl)Cl.CCCC[Li].[O-]S([O-])(=O)=O.[Cu+2]>[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][CH2:8][n:9]1[cH:10][c:11]([n:12][c:13]1[N:26]1[CH2:25][CH2:24][NH:29][CH2:28][CH2:27]1)-[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[C:20]([F:21])([F:22])[F:23]|EP3259254B1_0167
7.9.4|[c:6]1:[c:5]:[n&H1&+0&D2:4]:[c:3]:[c:2]:[c&H0&+0&D3:1]:1=O>>[c:6]1:[c:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[C&H2&+0&D2:1]-1|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]2[c:9]([c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[nH:16][c:17]21)=O>Cl.Cl[Al](Cl)Cl.C1CCOC1.[Li][AlH4]>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]2[CH2:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[NH:16][c:17]21|US20100061928A1_0351
9.5.4|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H1&+0&D3:3](-[C:2])-[C:1])-O>>[C&H3&D1:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[C:1]|[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5][CH2:6][CH:7]([C:8](=[O:9])[O:10][CH2:11][CH3:12])[CH:13]([CH3:14])O>CC(=O)OC(C)=O.Cc1ccccc1.CN(C)c1ccncc1.C1CN=C2CCCCCN2C1>[CH3:14][CH:13]=[C:7]([CH2:6][CH2:5][CH:4]=[C:2]([CH3:1])[CH3:3])[C:8](=[O:9])[O:10][CH2:11][CH3:12]|EP0005348A1_0175
2.5.5|[C:5]-[C&H0&+0&D2:4]#[N&H0&+0&D1:3].[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[N&H1&+0&D1:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][C:3]#[N:4].[NH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[N:12]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1>Cl[Al](Cl)Cl>[CH3:1][CH2:2][C:3](=[NH:4])[NH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[N:12]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1|US20200031835A1_1269
9.7.92|[N&H2&+0&D1:5]-[O&H1&D1:4].[N:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H0&+0&D2:5](-[O&H1&D1:4])=[C&H0&+0&D3:2](-[N:3])-[c:1]|[CH3:1][NH:2][c:3]1[n:4][c:5]([cH:6][s:7]1)-[c:8]1[cH:9][c:10]([n:11][o:12]1)[C:13](=O)[NH:14][c:15]1[cH:16][cH:17][c:18]([c:19]([cH:20]1)[Cl:21])[F:22].[NH2:23][OH:24]>ClP(Cl)(Cl)(Cl)Cl.c1ccccc1>[CH3:1][NH:2][c:3]1[n:4][c:5]([cH:6][s:7]1)-[c:8]1[cH:9][c:10]([n:11][o:12]1)[C:13](=[N:23][OH:24])[NH:14][c:15]1[cH:16][cH:17][c:18]([c:19]([cH:20]1)[Cl:21])[F:22]|US09951065B2_1651
1.3.9|[c:6]:[c&H0&+0&D3:5](:[n:4])-I.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][S:2][c:3]1[n:4][cH:5][cH:6][c:7]([n:8]1)I.[CH3:9][C:10]([CH3:11])([CH3:12])[O:13][C:14](=[O:15])[N:16]1[CH2:17][CH2:18][N:19]([CH2:20][CH2:21]1)[c:22]1[cH:23][cH:24][c:25]2[nH:26][c:27]([n:28][c:29]2[n:30]1)-[c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[F:37]>>[CH3:9][C:10]([CH3:11])([CH3:12])[O:13][C:14](=[O:15])[N:16]1[CH2:17][CH2:18][N:19]([CH2:20][CH2:21]1)[c:22]1[cH:23][cH:24][c:25]2[c:29]([n:30]1)[n:28][c:27]([n:26]2-[c:7]1[cH:6][cH:5][n:4][c:3]([n:8]1)[S:2][CH3:1])-[c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[F:37]|US20200031801A1_0493
7.6.1|[C:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[C&H1&+0&D3:3](-[c:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[C:7](=[C:8]([CH2:9][CH2:10][c:11]2[cH:12]1)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[OH:25]>CCO.[H][H].[OH-].[OH-].[Pd+2]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:11]([cH:12]1)[CH2:10][CH2:9][CH:8]([CH:7]2[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[OH:25])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US10647698B2_2006
4.1.107|[O&H0&-&D1:5]-[n&H0&+&D3:4](:[c:3]):[c&H1&+0&D2:2]:[c:1]>>[O&H0&+0&D1:5]=[c&H0&+0&D3:2](:[c:1]):[n&H1&+0&D2:4]:[c:3]|[O-:1][n+:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]([c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[cH:14][cH:15][c:16]21)=[O:17]>O.Cc1ccc(cc1)S(=O)(=O)Cl.O=C(O[K])O[K].ClC(Cl)Cl>[O:17]=[c:7]1[c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[cH:14][cH:15][c:16]2[nH:2][c:3]([cH:4][cH:5][c:6]12)=[O:1]|US20120129875A1_0235
3.11.34|[C:6]-[C&H2&+0&D2:5]-[c:4].[O:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:2](-[O:3])-[c:1]|[O:1]=[C:2]1[CH2:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[NH:10]1.O=[C:11]1[O:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]12>O.Cl.CN(C)C=O.[NaH]>[O:1]=[C:2]1[NH:10][c:9]2[cH:8][cH:7][cH:6][cH:5][c:4]2[C:3]1=[C:11]1[O:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]12|US20080045526A1_0106
4.1.107|[O&H0&-&D1:5]-[n&H0&+&D3:4](:[c:3]):[c&H1&+0&D2:2]:[c:1]>>[O&H1&+0&D1:5]-[c&H0&+0&D3:2](:[c:1]):[n&H0&+0&D2:4]:[c:3]|[CH3:1][c:2]1[n:3][c:4]2[cH:5][n+:6]([c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[c:13]2[n:14]1[CH3:15])[O-:16]>CC(=O)OC(C)=O>[CH3:1][c:2]1[n:3][c:4]2[c:13]([c:12]3[cH:11][cH:10][cH:9][cH:8][c:7]3[n:6][c:5]2[OH:16])[n:14]1[CH3:15]|US20200140412A1_0215
1.3.7|[C:6]-[N&H2&+&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[nH:3][c:4]([c:5]([c:6]1[Cl:7])[Cl:8])[C:9](=[O:10])[NH:11][CH:12]1[CH2:13][CH2:14][NH2+:15][CH2:16][CH2:17]1.[CH3:18][CH2:19][O:20][C:21](=[O:22])[c:23]1[cH:24][c:25]2[cH:26][cH:27][n:28][cH:29][c:30]2[c:31]([n:32]1)Cl.[O-]C(=O)C(F)(F)F>CC(C)(C)O.[O-]C([O-])=O.[K+].[K+]>[CH3:1][c:2]1[nH:3][c:4]([c:5]([c:6]1[Cl:7])[Cl:8])[C:9](=[O:10])[NH:11][CH:12]1[CH2:13][CH2:14][N:15]([CH2:16][CH2:17]1)[c:31]1[n:32][c:23]([cH:24][c:25]2[cH:26][cH:27][n:28][cH:29][c:30]21)[C:21](=[O:22])[O:20][CH2:19][CH3:18]|US20200172546A1_0459
3.11.34|[C:6]-[C&H2&+0&D2:5]-[S:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:6]-[C&H0&+0&D3:5](-[S:4])=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[c:7]1[cH:8][s:9][c:10]([n:11]1)[NH:12][C:13](=[O:14])[NH:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[O:22]=[C:23]([OH:24])[CH2:25][N:26]1[C:27]([S:28][CH2:29][C:30]1=[O:31])=[S:32]>N.[NH4+].[Cl-].Cl.CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[C:29]1[S:28][C:27]([N:26]([C:30]1=[O:31])[CH2:25][C:23](=[O:22])[OH:24])=[S:32])[c:7]1[cH:8][s:9][c:10]([n:11]1)[NH:12][C:13](=[O:14])[NH:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20040167192A1_0212
1.6.8|[C:6]-[C&H1&+0&D3:5](-[C:4])-I.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[c:2]1[cH:3][cH:4][c:5]([n:6][nH:7]1)-[c:8]1[c:9]([n:10][n:11]2[c:12]1[cH:13][cH:14][cH:15][cH:16]2)-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1.[CH3:23][C:24]([CH3:25])([CH3:26])[Si:27]([CH3:28])([CH3:29])[O:30][CH:31]1[CH2:32][CH2:33][CH2:34][CH:35]([CH2:36]1)I>C1COCCOCCOCCOCCOCCO1.CCCCCC.CCOC(C)=O.CC(C)(C)O[K].CN(C)C=O>[CH3:23][C:24]([CH3:25])([CH3:26])[Si:27]([CH3:28])([CH3:29])[O:30][CH:31]1[CH2:32][CH2:33][CH2:34][CH:35]([CH2:36]1)[n:7]1[n:6][c:5]([cH:4][cH:3][c:2]1=[O:1])-[c:8]1[c:9]([n:10][n:11]2[c:12]1[cH:13][cH:14][cH:15][cH:16]2)-[c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|US20130116231A1_0394
1.6.8|[C:6]-[C&H1&+0&D3:5](-[C:4])-I.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[NH2:1][C:2](=[O:3])[c:4]1[cH:5][c:6]2[c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[nH:13][c:14]2[n:15][c:16]1[NH2:17].[CH3:18][C:19]([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH2:26][CH:27]([CH2:28]1)I>O=C(O[Cs])O[Cs].CN(C)C=O>[CH3:18][C:19]([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH2:26][CH:27]([CH2:28]1)[n:13]1[c:14]2[n:15][c:16]([c:4]([cH:5][c:6]2[c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21)[C:2]([NH2:1])=[O:3])[NH2:17]|US20200399268A1_1164
3.11.91|[C:6]-[C&H1&+0&D3:5](-[C:4])-[N:3].[C:2]-[C&H2&+0&D2:1]-I>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[N:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:7][c:8]2[cH:9][c:10]([c:11]([cH:12][c:13]2[CH2:14][N:15]1[CH3:16])[O:17][CH3:18])[O:19][CH3:20].[CH3:21][O:22][c:23]1[cH:24][cH:25][c:26]([cH:27][c:28]1[O:29][CH3:30])[C:31]([C:32]#[N:33])([CH2:34][CH2:35][CH2:36]I)[CH:37]([CH3:38])[CH3:39]>>[CH3:30][O:29][c:28]1[cH:27][c:26]([cH:25][cH:24][c:23]1[O:22][CH3:21])[C:31]([C:32]#[N:33])([CH2:34][CH2:35][CH2:36][C:6]1([CH2:7][c:8]2[cH:9][c:10]([c:11]([cH:12][c:13]2[CH2:14][N:15]1[CH3:16])[O:17][CH3:18])[O:19][CH3:20])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[CH:37]([CH3:38])[CH3:39]|US07745637B2_0043
1.3.9|[C:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][C:3]1([C:4]([NH:5][c:6]2[c:7]1[cH:8][c:9]1[nH:10][c:11]3-[c:12]4[n:13][n:14]([cH:15][c:16]4[CH2:17][CH2:18][CH2:19][c:20]3[c:21]1[cH:22]2)[CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:28])([CH3:29])[CH3:30])=[O:31])[CH2:32][CH3:33].I[c:34]1[cH:35][cH:36][cH:37][cH:38][n:39]1>NC1CCCCC1N.O=P(O[K])(O[K])O[K].C1COCCO1.I[Cu]>[CH3:1][CH2:2][C:3]1([C:4]([N:5]([c:6]2[c:7]1[cH:8][c:9]1[nH:10][c:11]3-[c:12]4[n:13][n:14]([cH:15][c:16]4[CH2:17][CH2:18][CH2:19][c:20]3[c:21]1[cH:22]2)[CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:28])([CH3:29])[CH3:30])[c:34]1[cH:35][cH:36][cH:37][cH:38][n:39]1)=[O:31])[CH2:32][CH3:33]|US20200172546A1_1148
1.2.17|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[S:3].[N&H2&+0&D1:2]-[c:1]>>[C&H2&+0&D2:5](-[N&H1&+0&D2:2]-[c:1])-[C&H2&+0&D2:4]-[S:3]|[CH2:1]=[CH:2][S:3](=[O:4])(=[O:5])[F:6].[NH2:7][c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[Cl:14])[Cl:15]>O.CN(C)C=O>[O:4]=[S:3](=[O:5])([F:6])[CH2:2][CH2:1][NH:7][c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[Cl:14])[Cl:15]|EP0948486B1_0046
9.7.92|[N&H2&+0&D1:5]-[O&H1&D1:4].[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H0&+0&D2:5](\[O&H1&D1:4])=[C&H0&+0&D3:2](/[c:3])-[c:1]|Cl.[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=O)[c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)[CH2:15][N:16]([CH2:17][C:18](=[O:19])[OH:20])[CH2:21][CH3:22])[N+:23]([O-:24])=[O:25].[NH2:26][OH:27]>CCO.F[K]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)/[C:8](=[N:26]\[OH:27])[c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)[CH2:15][N:16]([CH2:21][CH3:22])[CH2:17][C:18](=[O:19])[OH:20])[N+:23]([O-:24])=[O:25]|US20200206225A1_0363
9.5.4|[C&H3&D1:5]-[C&H0&+0&D4:4](-[c:3])(-[C&H2&+0&D2:2]-[n:1])-O>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[n:1]|[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][c:8]2[c:9]3[cH:10][c:11]([cH:12][cH:13][c:14]3[n:15]([c:16]2[CH2:17][CH2:18]1)[CH2:19][C:20]([CH3:21])(O)[c:22]1[cH:23][cH:24][n:25][cH:26][cH:27]1)[CH3:28]>O=S(Cl)Cl.O=C(O)O[Na]>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][c:8]2[c:9]3[cH:10][c:11]([cH:12][cH:13][c:14]3[n:15]([c:16]2[CH2:17][CH2:18]1)[CH:19]=[C:20]([CH3:21])[c:22]1[cH:23][cH:24][n:25][cH:26][cH:27]1)[CH3:28]|US08907097B2_0979
1.3.8|[S:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[S:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][NH:2][C:3](=[O:4])[c:5]1[c:6]([o:7][c:8]2[cH:9][c:10]([c:11]([cH:12][c:13]12)[CH:14]1[CH2:15][CH2:16]1)[NH:17][S:18]([CH3:19])(=[O:20])=[O:21])-[c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28].[O-:29][N+:30](=[O:31])[c:32]1[cH:33][cH:34][c:35]([cH:36][c:37]1[Cl:38])F>O.COCCOC.O=C(O[K])O[K]>[CH3:1][NH:2][C:3](=[O:4])[c:5]1[c:6]([o:7][c:8]2[cH:9][c:10]([c:11]([cH:12][c:13]21)[CH:14]1[CH2:15][CH2:16]1)[N:17]([c:35]1[cH:34][cH:33][c:32]([c:37]([cH:36]1)[Cl:38])[N+:30]([O-:29])=[O:31])[S:18]([CH3:19])(=[O:20])=[O:21])-[c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28]|US09119868B2_0500
1.3.9|[C:6]-[N&H1&+0&D2:5]-[N:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]-[N&H0&+0&D3:5](-[N:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][cH:8][cH:9][c:10]2[N:11]2[CH2:12][CH2:13][N:14]([CH2:15][CH2:16]2)[CH2:17][CH2:18][c:19]2[cH:20][cH:21][cH:22][c:23]([cH:24]2)I)[n:25]1.[CH3:26][C:27]1[CH2:28][C:29]([NH:30][N:31]=1)=[O:32]>>[CH3:26][C:27]1[CH2:28][C:29]([N:30]([N:31]=1)[c:23]1[cH:22][cH:21][cH:20][c:19]([cH:24]1)[CH2:18][CH2:17][N:14]1[CH2:13][CH2:12][N:11]([CH2:16][CH2:15]1)[c:10]1[cH:9][cH:8][cH:7][c:6]2[n:25][c:2]([cH:3][cH:4][c:5]21)[CH3:1])=[O:32]|US20180079745A1_0233
9.7.41|[C&H0&-&D1:5]#[N&H0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|Cl[c:1]1[n:2][c:3]2[c:4]([n:5][cH:6][n:7]2[CH:8]2[CH2:9][CH2:10][CH2:11][CH2:12][O:13]2)[c:14]([n:15]1)[NH:16][CH2:17][CH:18]([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1.[C-:31]#[N:32].[C-]#N.[Zn+2]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCN(CC)CC.CN(C)C=O.[Pd]>[N:32]#[C:31][c:1]1[n:2][c:3]2[c:4]([n:5][cH:6][n:7]2[CH:8]2[CH2:9][CH2:10][CH2:11][CH2:12][O:13]2)[c:14]([n:15]1)[NH:16][CH2:17][CH:18]([c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1|EP3546457A1_0168
1.2.9|[C:6]-[C&H0&+0&D3:5](=[C:4])-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[O:1]=[C:2]1[CH:3]=[C:4]([CH2:5][O:6]1)O.[F:7][c:8]1[cH:9][c:10]([cH:11][n:12][c:13]1[Cl:14])[CH2:15][NH:16][CH2:17][CH:18]([F:19])[F:20]>[H+].[OH2-]>[O:1]=[C:2]1[CH:3]=[C:4]([CH2:5][O:6]1)[N:16]([CH2:15][c:10]1[cH:11][n:12][c:13]([c:8]([cH:9]1)[F:7])[Cl:14])[CH2:17][CH:18]([F:19])[F:20]|US20170275283A1_0265
1.3.9|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[N:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1.[I:17][c:18]1[cH:19][cH:20][c:21]([n:22][n:23]1)I>CC(=O)N(C)C.O=C(O[Na])O[Na]>[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[N:11]1[CH2:12][CH2:13][N:14]([CH2:15][CH2:16]1)[c:21]1[cH:20][cH:19][c:18]([n:23][n:22]1)[I:17]|EP3368539B1_0315
1.2.9|[C:6]-[C&H1&+0&D3:5](-[O:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H1&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|O[CH:1]1[O:2][CH:3]([CH:4]([CH:5]([CH:6]1[O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[O:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[CH2:31][O:32][CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1.[O:40]=[C:41]1[C:42](=[C:43]([C:44]([N:45]1[CH2:46][O:47][CH2:48][c:49]1[cH:50][cH:51][cH:52][cH:53][cH:54]1)=[O:55])[c:56]1[cH:57][nH:58][c:59]2[c:60]1[cH:61][c:62]([cH:63][cH:64]2)[O:65][CH2:66][c:67]1[cH:68][cH:69][cH:70][cH:71][cH:72]1)[Br:73]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CC(C)OC(=O)N=NC(=O)OC(C)C>[O:40]=[C:41]1[C:42](=[C:43]([C:44]([N:45]1[CH2:46][O:47][CH2:48][c:49]1[cH:54][cH:53][cH:52][cH:51][cH:50]1)=[O:55])[c:56]1[cH:57][n:58]([c:59]2[c:60]1[cH:61][c:62]([cH:63][cH:64]2)[O:65][CH2:66][c:67]1[cH:68][cH:69][cH:70][cH:71][cH:72]1)[CH:1]1[O:2][CH:3]([CH:4]([CH:5]([CH:6]1[O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[O:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[CH2:31][O:32][CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)[Br:73]|US09243025B2_0777
10.4.15|[C:5]-[N&H1&+0&D2:4]-[C:3].[O&H0&D1:2]=[N&H0&+0&D2:1]-[O&-]>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[N&H0&+0&D2:1]=[O&H0&D1:2]|[Na+].[CH3:1][CH2:2][N:3]1[CH2:4][CH2:5][NH:6][C:7]1=[S:8].[O-][N:9]=[O:10]>O.Cl.ClCCl>[CH3:1][CH2:2][N:3]1[CH2:4][CH2:5][N:6]([C:7]1=[S:8])[N:9]=[O:10]|US20190270739A1_0750
1.2.9|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][n:9][c:10]([n:11][c:12]1O)[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1.[CH3:19][CH2:20][NH:21][CH2:22][CH3:23]>O.CCO.O=P(Cl)(Cl)Cl>[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[c:12]1[n:11][c:10]([n:9][cH:8][c:7]1[CH2:6][C:4](=[O:5])[O:3][CH2:2][CH3:1])[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1|US20200061068A1_0144
3.11.93|[C&H3&+0&D1:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H2&+0&D2:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4]([CH3:5])=[O:6].[O:7]=[C:8](O)[c:9]1[cH:10][c:11]([c:12]([n:13][c:14]1[NH:15][c:16]1[cH:17][cH:18][c:19]([cH:20][c:21]1[F:22])[F:23])[Cl:24])[F:25]>O.Cl.CCOC(=O)CC([O-])=O.CCOC(=O)CC([O-])=O.O=C(n1ccnc1)n1ccnc1.C1CCOC1.[Mg+2]>[CH3:1][CH2:2][O:3][C:4](=[O:6])[CH2:5][C:8](=[O:7])[c:9]1[cH:10][c:11]([c:12]([n:13][c:14]1[NH:15][c:16]1[cH:17][cH:18][c:19]([cH:20][c:21]1[F:22])[F:23])[Cl:24])[F:25]|US20200055842A1_1938
9.7.65|[N&H2&+0&D1:5]-[N&H2&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|O.[CH2:1]=[CH:2][CH2:3][c:4]1[c:5]([c:6]([c:7]([c:8]([c:9]1[F:10])[F:11])F)[F:12])[F:13].[NH2:14][NH2:15]>CCO>[CH2:1]=[CH:2][CH2:3][c:4]1[c:5]([c:6]([c:7]([c:8]([c:9]1[F:10])[F:11])[NH:15][NH2:14])[F:12])[F:13]|EP2699562B1_0582
1.2.9|[C:6]-[C&H1&+0&D3:5](-[c:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH:4](O)[c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[O:11][CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[Cl:19])[Cl:20])[C:21]#[N:22].[cH:23]1[cH:24][nH:25][cH:26][n:27]1>CCCC(Cl)c1ccc(cc1OCc1ccc(cc1Cl)Cl)C#N.N#Cc1ccccc1.C1COCCO1.CN(C)C=O.O=S(Cl)Cl.[Na+].[BH4-].[Na]>[CH3:1][CH2:2][CH2:3][CH:4]([c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[O:11][CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[Cl:19])[Cl:20])[C:21]#[N:22])[n:25]1[cH:26][n:27][cH:23][cH:24]1|US10683290B2_0444
1.3.8|[c:6]:[c&H0&+0&D3:5](:[c:4])-F.[n:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1F)[C:8]#[N:9].[cH:10]1[cH:11][n:12][nH:13][n:14]1>O.CN(C)C=O.O=C(O[K])O[K]>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1-[n:13]1[n:14][cH:10][cH:11][n:12]1)[C:8]#[N:9]|US20200039945A1_0584
1.2.17|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[S:3].[C:2]-[N&H2&+0&D1:1]>>[C&H2&+0&D2:5](-[N&H1&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[S:3]|[CH2:1]=[CH:2][S:3](=[O:4])(=[O:5])[N:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[O:12][c:13]1[cH:14][cH:15][c:16]([c:17]([cH:18]1)[O:19][CH3:20])[CH2:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][N:27]([CH2:28][CH:29]1[C:30]([NH2:31])=[O:32])[c:33]1[cH:34][cH:35][cH:36][cH:37][c:38]1[CH3:39].[NH2:40][CH:41]1[CH2:42][CH2:43]1>CO>[CH3:20][O:19][c:17]1[cH:18][c:13]([cH:14][cH:15][c:16]1[CH2:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][N:27]([CH2:28][CH:29]1[C:30]([NH2:31])=[O:32])[c:33]1[cH:34][cH:35][cH:36][cH:37][c:38]1[CH3:39])[O:12][CH:9]1[CH2:10][CH2:11][N:6]([CH2:7][CH2:8]1)[S:3](=[O:4])(=[O:5])[CH2:2][CH2:1][NH:40][CH:41]1[CH2:42][CH2:43]1|US20110166161A1_0367
3.9.12|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=C.[C:2]-[C&H1&+0&D2:1]=C>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:1]-[C:2]|C=[CH:1][CH2:2][CH2:3][C:4]1([CH2:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[C:12]1([OH:13])[C:14](=C)[CH3:15])[O:16][CH3:17])[CH2:18][CH2:19][CH:20]=[CH2:21]>>[CH2:21]=[CH:20][CH2:19][CH2:18][C:4]12[CH2:3][CH2:2][CH:1]=[C:14]([C:12]1([c:11]1[cH:10][cH:9][c:8]([cH:7][c:6]1[CH2:5]2)[O:16][CH3:17])[OH:13])[CH3:15]|US20110092591A1_0023
2.4.8|[O&H0&D1:5]=[C&H0&+0&D3:4](-[O:3])-O-C.[O&H1&+0&D1:2]-[c:1]>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[O:3]|CO[C:1](=[O:2])[O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[OH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>COC(=O)OC>[O:2]=[C:1]([O:3][c:4]1[cH:9][cH:8][cH:7][cH:6][cH:5]1)[O:10][c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|EP2995604A1_0382
1.3.3|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][n:2]1[cH:3][cH:4][c:5]2[c:6]1[cH:7][c:8]([cH:9][cH:10]2)I.[CH2:11]1[CH2:12][NH:13][CH2:14][CH2:15][O:16]1>c1ccc(cc1)P(c1ccccc1)c1ccc2ccccc2c1-c1c2ccccc2ccc1P(c1ccccc1)c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.C1COCCOCCOCCOCCOCCO1.CC(C)(C)[O-].[Na+].[Pd].[Pd]>[CH3:1][n:2]1[cH:3][cH:4][c:5]2[c:6]1[cH:7][c:8]([cH:9][cH:10]2)[N:13]1[CH2:12][CH2:11][O:16][CH2:15][CH2:14]1|US08383638B2_0260
2.5.5|[C:5]-[N&H2&+0&D1:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[N:1]>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[N&H1&+0&D1:3])-[N:1]|[N:1]#[C:2][NH:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1.[NH2:12][CH:13]1[CH2:14][CH2:15][N:16]([CH2:17][CH2:18]1)[CH2:19][c:20]1[cH:21][cH:22][c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[cH:29]1>Cc1ccccc1>[NH:1]=[C:2]([NH:3][C:4](=[O:5])[c:6]1[cH:11][cH:10][cH:9][cH:8][cH:7]1)[NH:12][CH:13]1[CH2:14][CH2:15][N:16]([CH2:17][CH2:18]1)[CH2:19][c:20]1[cH:21][cH:22][c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[cH:29]1|US09988390B2_0247
9.7.65|[N&H2&+0&D1:5]-[N&H2&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|O.[NH2:1][NH2:2].[OH:3][CH2:4][c:5]1[c:6]([c:7]([n:8][c:9]([c:10]1[F:11])F)[F:12])[F:13]>CCO>[NH2:1][NH:2][c:9]1[n:8][c:7]([c:6]([c:5]([c:10]1[F:11])[CH2:4][OH:3])[F:13])[F:12]|US20190381019A1_1381
10.4.3|[O&H2&+0&D0:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[O&H1&+0&D1:5]-[C&H1&+0&D3:2](-[C:1])-[C&H2&+0&D2:3]-[C:4]|[OH2:1].[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]2[c:8]([cH:9]1)[CH2:10][CH2:11][C@@H:12]1[C@@H:13]2[CH2:14][CH2:15][C@:16]2([C@H:17]1[CH2:18][CH2:19][C:20]21[CH:21]=[CH:22][CH2:23][O:24]1)[CH3:25]>Cl.OO.O[Na].C1CCOC1.B>[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]2[c:8]([cH:9]1)[CH2:10][CH2:11][C@@H:12]1[C@@H:13]2[CH2:14][CH2:15][C@:16]2([C@H:17]1[CH2:18][CH2:19][C:20]21[CH2:21][CH:22]([CH2:23][O:24]1)[OH:1])[CH3:25]|US20200002330A1_0292
1.2.17|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[c:3].[C:2]-[N&H2&+0&D1:1]>>[C&H2&+0&D2:5](-[N&H1&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[c:3]|[CH2:1]=[CH:2][c:3]1[cH:4][n:5][cH:6][cH:7][n:8]1.[CH3:9][CH2:10][NH2:11]>O.CO.CC(=O)O.O[Na]>[CH3:9][CH2:10][NH:11][CH2:1][CH2:2][c:3]1[cH:4][n:5][cH:6][cH:7][n:8]1|US20200190045A1_0539
1.2.16|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[N&H2&+0&D1:2]-[c:1]>>[C&H2&+0&D2:5](-[N&H1&+0&D2:2]-[c:1])-[C&H2&+0&D2:4]-[C:3]|[CH2:1]=[CH:2][C:3]([CH3:4])=[O:5].[NH2:6][c:7]1[cH:8][c:9]([cH:10][c:11]([c:12]1[O:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[S:20]([NH2:21])(=[O:22])=[O:23])[C:24](=[O:25])[OH:26]>CCO.CC(C)=O>[CH3:4][C:3](=[O:5])[CH2:2][CH2:1][NH:6][c:7]1[cH:8][c:9]([cH:10][c:11]([c:12]1[O:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)[S:20]([NH2:21])(=[O:22])=[O:23])[C:24](=[O:25])[OH:26]|US20200190066A1_0316
2.5.7|[C&H3&D1:5]-[N&H2&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-S-C>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][NH2:2].[CH3:3][CH2:4][CH:5]([CH3:6])[c:7]1[n:8][n:9][c:10]([n:11]([c:12]1=[O:13])[NH2:14])SC>Cc1ccc(cc1)S(=O)(=O)O.CC(=O)O>[CH3:3][CH2:4][CH:5]([CH3:6])[c:7]1[n:8][n:9][c:10]([n:11]([c:12]1=[O:13])[NH2:14])[NH:2][CH3:1]|US08673905B2_0321
1.3.9|[C:6]-[C&H0&+0&D3:5](=[C:4])-I.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H0&+0&D3:5](=[C:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH2:1]=[CH:2][CH2:3][O:4][N:5]1[C:6]([N:7]2[CH2:8][C:9](=[CH:10][CH:11]1[CH2:12]2)I)=[O:13].[cH:14]1[cH:15][cH:16][nH:17][n:18]1>CS(C)=O.O=C(O[K])O[K].I[Cu]>[CH2:1]=[CH:2][CH2:3][O:4][N:5]1[C:6]([N:7]2[CH2:12][CH:11]1[CH:10]=[C:9]([CH2:8]2)[n:17]1[cH:16][cH:15][cH:14][n:18]1)=[O:13]|EP3301094A1_0123
9.5.4|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[C&H1&+0&D3:2](-[c:1])-O>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[CH:8](O)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[O:15][CH3:16]>c1ccccc1.[O-]S(=O)(=O)O.[K+]>[CH3:16][O:15][c:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[CH:8]=[C:6]([CH3:7])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20200131284A1_0298
1.3.8|[c:6]:[c&H0&+0&D3:5](:[c:4])-F.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1F.[O:10]=[c:11]1[cH:12][cH:13][s:14][c:15]2[c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[nH:22][c:23]12>>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1-[n:22]1[c:23]2[c:15]([s:14][cH:13][cH:12][c:11]2=[O:10])[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21|US10112938B2_0773
2.1.5|[N&H2&+0&D1:5]-[S:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H1&+0&D2:5](-[S:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[Cl-:1].[NH2:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][s:9][c:10]1[C:11](=[O:12])O>O=S(Cl)Cl>[Cl-:1].[O:12]=[C:11]1[NH:2][S:3]([c:6]2[cH:7][cH:8][s:9][c:10]12)(=[O:4])=[O:5]|US10093640B2_1584
3.11.93|[C&H3&+0&D1:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H2&+0&D2:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C:2](=[O:3])[CH2:4][C:5]([CH3:6])([CH3:7])[CH2:8][C:9](=[O:10])O>O=S(=O)(O)O.ClC(Cl)Cl>[CH3:6][C:5]1([CH2:4][C:2]([CH2:1][C:9]([CH2:8]1)=[O:10])=[O:3])[CH3:7]|EP2714030B1_0135
1.2.9|[C:6]-[C&H1&+0&D3:5](-[c:4])-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]([NH:3][C:4]1=[N:5][CH2:6][CH2:7][NH:8]1)[CH:9](O)[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>O=S(=O)(O)O.O[Na]>[CH3:1][CH:2]1[NH:3][C:4]2=[N:5][CH2:6][CH2:7][N:8]2[CH:9]1[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US20120214798A1_1075
1.2.16|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[C:2]-[N&H2&+0&D1:1]>>[C&H2&+0&D2:5](-[N&H1&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[C:3]|Cl.[CH2:1]=[CH:2][C:3](=[O:4])[O:5][CH2:6][CH3:7].[NH2:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[N+:16]([O-:17])=[O:18]>O.Cl.CCO.CC(N)C(=O)O.O[Na]>[CH3:7][CH2:6][O:5][C:3](=[O:4])[CH2:2][CH2:1][NH:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[N+:16]([O-:17])=[O:18]|EP3008068B1_0277
1.2.5|[C:6]-[C&H0&+0&D3:5](-[c:4])=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|O=[C:1]1[CH2:2][CH2:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]12.[CH2:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[cH:7]1[cH:6][cH:5][c:4]2[CH2:3][CH2:2][CH:1]([c:9]2[cH:8]1)[N:13]1[CH2:14][CH2:15][CH2:10][CH2:11][CH2:12]1|EP3307729B1_0175
7.6.1|[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:3](-[c:2])-[c:1]|[Cl:1][c:2]1[cH:3][cH:4][c:5]2[CH2:6][CH:7]3[CH2:8][N:9]([CH2:10][C:11]3=[C:12]([c:13]2[cH:14]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>[Na+].I.CC(=O)O.[OH-].[P]>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[CH2:6][CH:7]3[CH2:8][N:9]([CH2:10][CH:11]3[CH:12]([c:13]2[cH:14]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|US20200392125A1_0855
9.7.25|[C&H0&-&D1:5]#[N&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[C-:1]#[N:2].[CH3:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]2[c:10]([cH:11]1)[CH2:12][c:13]1[cH:14][c:15]([cH:16][cH:17][c:18]-21)Br.[Cu+]>ClCCl.c1cc2ccccc2nc1>[CH3:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]2[c:10]([cH:11]1)[CH2:12][c:13]1[cH:14][c:15]([cH:16][cH:17][c:18]-21)[C:1]#[N:2]|EP2912032B1_0123
2.5.5|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[N:3].[N&H2&+0&D1:2]-[c:1]>>[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[N:3]|[ClH:1].[CH3:2][NH:3][C:4]#[N:5].[NH2:6][c:7]1[c:8]([cH:9][cH:10][cH:11][c:12]1[Cl:13])[Cl:14]>CCOCC.Cc1cccc(c1)O.O[Na]>[ClH:1].[CH3:2][NH:3][C:4](=[NH:5])[NH:6][c:7]1[c:12]([cH:11][cH:10][cH:9][c:8]1[Cl:14])[Cl:13]|EP0693053B1_0078
1.2.9|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[c:3])-[c:1]|O[CH:1]1[c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[S:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21.[CH:15](=[CH:16][CH2:17][N:18]1[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>O.Cc1ccccc1.CC(=O)O.C>[CH:16](=[CH:15][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[CH2:17][N:18]1[CH2:23][CH2:22][N:21]([CH2:20][CH2:19]1)[CH:1]1[c:14]2[cH:13][cH:12][cH:11][cH:10][c:9]2[S:8][c:7]2[cH:6][cH:5][cH:4][cH:3][c:2]21|US10669272B2_0850
7.6.1|[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:3](-[C:2])-[c:1]|[O:1]=[C:2]1[CH2:3][CH2:4][C:5]2=[C:6]1[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]21>CCO.[H][H].[Pd]>[O:1]=[C:2]1[CH2:3][CH2:4][CH:5]2[c:13]3[cH:12][cH:11][cH:10][cH:9][c:8]3[CH2:7][CH:6]12|EP2998292A1_0161
3.11.85|[C:6]-[C&H2&+0&D2:5]-I.[C:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([C:7]#[N:8])[c:9]1[cH:10][cH:11][cH:12][c:13]([c:14]1[O:15][CH3:16])[O:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[CH3:24].[CH3:25][CH2:26][CH2:27][CH2:28]I>CN(C)C=O.[NaH]>[CH3:25][CH2:26][CH2:27][CH2:28][C:6]([C:7]#[N:8])([C:4](=[O:5])[O:3][CH2:2][CH3:1])[c:9]1[cH:10][cH:11][cH:12][c:13]([c:14]1[O:15][CH3:16])[O:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[CH3:24]|US20200407353A1_0305
9.7.25|[C&H0&-&D1:5]#[N&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[C-]#N.[C-:1]#[N:2].[CH3:3][C:4](=[O:5])[O:6][CH2:7][c:8]1[n:9][c:10]([c:11]([n:12]1[CH3:13])Br)[N+:14]([O-:15])=[O:16].[Cu+2]>CN(C)C=O>[CH3:3][C:4](=[O:5])[O:6][CH2:7][c:8]1[n:9][c:10]([c:11]([n:12]1[CH3:13])[C:1]#[N:2])[N+:14]([O-:15])=[O:16]|EP3070077B1_0418
3.11.34|[C:6]-[C&H2&+0&D2:5]-[C:4].[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][CH2:6][O:7][C:8](=[O:9])[CH2:10][C:11]#[N:12].O=[C:13]([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>[NH4+].O.Cc1ccccc1.CC([O-])=O.CC(=O)O>[CH3:1][C:2](=[O:3])[O:4][CH2:5][CH2:6][O:7][C:8](=[O:9])[C:10]([C:11]#[N:12])=[C:13]([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|US20090062253A1_0502
2.1.3|[N&H2&+0&D1:5]-[N:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H1&+0&D2:5](-[N:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=[O:10])O.[NH2:11][NH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>O=S(Cl)Cl.c1ccncc1>[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=[O:10])[NH:11][NH:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|US20080293711A1_7092
9.7.92|[N&H2&+0&D1:5]-[O&H1&D1:4].[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H0&+0&D2:5](-[O&H1&D1:4])=[C&H0&+0&D3:2](-[c:3])-[c:1]|Cl.[NH2:1][OH:2].O=[C:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH:10]2[CH2:11][CH:12]2[c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]12>c1ccncc1>[OH:2][N:1]=[C:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH:10]2[CH2:11][CH:12]2[c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]12|EP3345906A1_0054
1.3.9|[c:6]:[c&H0&+0&D3:5](:[c:4])-I.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)I.[cH:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[NH:15][c:16]1[cH:17][cH:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[cH:25]1>[O-][N+](=O)c1ccccc1.O=C(O[K])O[K].[Cu]>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[N:15]([c:12]1[cH:11][cH:10][cH:9][cH:14][cH:13]1)[c:16]1[cH:17][cH:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[cH:25]1|US09705092B2_0058
1.7.12|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[O:3].[C:2]-[O&H1&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[O:3]|[CH2:1]=[CH:2][O:3][CH2:4][CH3:5].[CH2:6]=[CH:7][C:8]([CH3:9])([OH:10])[CH2:11][CH2:12][CH:13]=[C:14]([CH3:15])[CH3:16]>O=S(=O)(O)O>[CH2:6]=[CH:7][C:8]([CH3:9])([CH2:11][CH2:12][CH:13]=[C:14]([CH3:15])[CH3:16])[O:10][CH:2]([CH3:1])[O:3][CH2:4][CH3:5]|US20180307140A1_0222
1.2.5|[C:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][N:2]([CH3:3])[C:4]1([CH2:5][CH2:6][C:7]([CH2:8][CH2:9]1)=O)[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16].[CH2:17]1[CH2:18][NH:19][CH2:20][CH2:21][O:22]1>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1.CCOCC.C1CCOC1.CCO.O.[Na+].[BH4-]>[CH3:1][N:2]([CH3:3])[C:4]1([CH2:5][CH2:6][CH:7]([CH2:8][CH2:9]1)[N:19]1[CH2:20][CH2:21][O:22][CH2:17][CH2:18]1)[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16]|EP2475661B1_0318
1.7.12|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[O:3].[O&H1&+0&D1:2]-[c:1]>>[C&H3&+0&D1:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[O:3]|[CH2:1]=[CH:2][O:3][CH2:4][CH2:5][Cl:6].[OH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[O:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>Cl.CCOCC>[CH3:1][CH:2]([O:3][CH2:4][CH2:5][Cl:6])[O:7][c:8]1[cH:13][cH:12][c:11]([cH:10][cH:9]1)[O:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|US20200399560A1_0069
1.2.9|[C:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|O[c:1]1[n:2][c:3]2[n:4][cH:5][c:6]([cH:7][c:8]2[c:9]2[cH:10][cH:11][cH:12][n:13]21)[Br:14].[CH3:15][N:16]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH:24]1[CH2:25][NH:26][CH2:27]1.Cl>CC(C)N(CC)C(C)C.O=P(Cl)(Cl)Cl>[CH3:21][C:20]([CH3:22])([CH3:23])[O:19][C:17](=[O:18])[N:16]([CH3:15])[CH:24]1[CH2:25][N:26]([CH2:27]1)[c:1]1[n:2][c:3]2[n:4][cH:5][c:6]([cH:7][c:8]2[c:9]2[cH:10][cH:11][cH:12][n:13]21)[Br:14]|EP0023559A1_0193
1.2.20|[C&H3&D1:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[N:1])-O-C>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[N:1]|[CH3:1][NH2:2].[CH3:3][c:4]1[nH:5][cH:6][n:7][c:8]1[CH2:9][S:10][CH2:11][CH2:12][NH:13][C:14]1=[N:15][S:16]([N:17]=[C:18]1OC)=[O:19]>Cc1[nH]cnc1CSCCN>[CH3:1][NH:2][C:18]1=[N:17][S:16]([N:15]=[C:14]1[NH:13][CH2:12][CH2:11][S:10][CH2:9][c:8]1[n:7][cH:6][nH:5][c:4]1[CH3:3])=[O:19]|EP0040696A2_0071
2.5.5|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3].[N&H2&+0&D1:2]-[c:1]>>[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[c:3]|[CH3:1][CH2:2][CH2:3][CH2:4][n:5]1[c:6]2[cH:7][cH:8][c:9]([cH:10][c:11]2[c:12]2[cH:13][c:14]([cH:15][cH:16][c:17]21)[C:18]#[N:19])[C:20]#[N:21].[NH2:22][c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[C:29]([F:30])([F:31])[F:32]>CS(C)=O.O.[NaH]>[CH3:1][CH2:2][CH2:3][CH2:4][n:5]1[c:6]2[cH:7][cH:8][c:9]([cH:10][c:11]2[c:12]2[cH:13][c:14]([cH:15][cH:16][c:17]21)[C:18](=[NH:19])[NH:22][c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[C:29]([F:30])([F:31])[F:32])[C:20]#[N:21]|US20200274076A1_0125
3.11.91|[C&H3&+0&D1:5]-I.[C&H3&D1:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH:7]([C:8]([c:9]2[c:10]([c:11]1[Cl:12])[Cl:13])=[O:14])[CH3:15].[CH3:16]I>COCCOC.[NaH]>[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][C:7]([C:8]([c:9]2[c:10]([c:11]1[Cl:12])[Cl:13])=[O:14])([CH3:16])[CH3:15]|US20200247754A1_0441
3.11.91|[C:6]-[C&H2&+0&D2:5]-I.[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH:7]([C:8]([c:9]2[c:10]([c:11]1[Cl:12])[Cl:13])=[O:14])[CH2:15][CH3:16].[CH3:17][CH2:18][CH2:19]I>COCCOC.[NaH]>[CH3:17][CH2:18][CH2:19][C:7]1([CH2:6][c:5]2[cH:4][c:3]([c:11]([c:10]([c:9]2[C:8]1=[O:14])[Cl:13])[Cl:12])[O:2][CH3:1])[CH2:15][CH3:16]|US20200061068A1_0105
2.5.7|[C:5]-[N&H2&+0&D1:4].[N&H1&D1:3]=[C&H0&+0&D3:2](-[N:1])-S-C>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[N&H1&D1:3])-[N:1]|CS[C:1](=[NH:2])[NH:3][N+:4]([O-:5])=[O:6].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][n:17]1>CO>[NH:2]=[C:1]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][n:17]1)[NH:3][N+:4]([O-:5])=[O:6]|US20050228182A1_0299
3.11.31|[C&H3&D1:5]-[C&H2&+0&D2:4]-[N&+:3].[c:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&+:3])=[C&H1&+0&D2:1]-[c:2]|[CH3:1][CH2:2][N+:3]([O-:4])=[O:5].O=[CH:6][c:7]1[cH:8][nH:9][c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]12)[Cl:16]>[NH4+].CC([O-])=O>[CH3:1][C:2](=[CH:6][c:7]1[cH:8][nH:9][c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]21)[Cl:16])[N+:3]([O-:4])=[O:5]|US20070072920A1_0077
1.7.12|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[O&H1&+0&D1:2]-[c:1]>>[C&H3&+0&D1:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:2]-[c:1]|[CH2:1]=[CH:2][CH2:3][c:4]1[cH:5][c:6]2[c:7]([cH:8][c:9]([o:10][c:11]2[c:12]([c:13]1[OH:14])[O:15][CH3:16])=[O:17])[CH3:18]>O.O=S(=O)(O)O>[CH3:16][O:15][c:12]1[c:11]2[o:10][c:9]([cH:8][c:7]([c:6]2[cH:5][c:4]2[CH2:3][CH:2]([O:14][c:13]12)[CH3:1])[CH3:18])=[O:17]|US20170107207A1_0325
2.1.2|[N&H2&+0&D1:5]-[c:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][N:2]1[CH2:3][C:4]([NH:5][C:6]1=[N:7][C:8](=[O:9])O)=[O:10].[NH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][n:17]1>>[CH3:1][N:2]1[CH2:3][C:4]([NH:5][C:6]1=[N:7][C:8](=[O:9])[NH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][n:17]1)=[O:10]|US07253286B2_2734
9.7.25|[C&H0&-&D1:5]#[N&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[C-:1]#[N:2].[O:3]=[C:4]([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][cH:13][c:14]([s:15]1)Br.[Cu+]>c1cc2ccccc2nc1>[N:2]#[C:1][c:14]1[cH:13][cH:12][c:11]([s:15]1)[C:4](=[O:3])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|US20190322682A1_0283
2.5.5|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3].[N&H2&+0&D1:2]-[c:1]>>[N&H2&+0&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[c:1])-[c:3]|[ClH:1].[CH3:2][n:3]1[cH:4][c:5]([c:6]([n:7]1)[NH:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[NH2:15])[N+:16]([O-:17])=[O:18])[C:19]#[N:20]>CC(C)O>[ClH:1].[CH3:2][n:3]1[cH:4][c:5]2[C:19](=[N:15][c:14]3[cH:13][c:12]([cH:11][cH:10][c:9]3[NH:8][c:6]2[n:7]1)[N+:16]([O-:17])=[O:18])[NH2:20]|US08871361B2_0452
9.7.260|[C&H3&+0&D1:5]-[c:4]:[n&H0&+&D3:3](-[O&H0&-&D1:2]):[c:1]>>[C&H2&+0&D2:5](-[O&H1&+0&D1:2])-[c:4]:[n&H0&+0&D2:3]:[c:1]|[CH3:1][c:2]1[cH:3][cH:4][n+:5]([c:6]([c:7]1[Br:8])[CH3:9])[O-:10]>O.Cl.CCO.CC(=O)OC(C)=O>[CH3:1][c:2]1[cH:3][cH:4][n:5][c:6]([c:7]1[Br:8])[CH2:9][OH:10]|US20200016136A1_0070
1.2.9|[c:6]:[c&H0&+0&D3:5](:[c:4])-O.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|O[c:1]1[cH:2][cH:3][cH:4][c:5]2[c:6]1-[c:7]1[cH:8][cH:9][c:10]([cH:11][c:12]1[C:13]2([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[N:26]([c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)-[c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1)[c:39]1[cH:40][cH:41][cH:42][cH:43][c:44]1-[c:45]1[cH:46][cH:47][cH:48][cH:49][cH:50]1.[cH:51]1[cH:52][cH:53][c:54]([cH:55][cH:56]1)-[c:57]1[cH:58][cH:59][c:60]([cH:61][cH:62]1)[NH:63][c:64]1[cH:65][cH:66][c:67]([cH:68][cH:69]1)-[c:70]1[cH:71][cH:72][cH:73][cH:74][cH:75]1>O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F>[cH:36]1[cH:37][cH:38][c:33]([cH:34][cH:35]1)-[c:30]1[cH:29][cH:28][c:27]([cH:32][cH:31]1)[N:26]([c:39]1[cH:40][cH:41][cH:42][cH:43][c:44]1-[c:45]1[cH:46][cH:47][cH:48][cH:49][cH:50]1)[c:10]1[cH:9][cH:8][c:7]2-[c:6]3[c:1]([cH:2][cH:3][cH:4][c:5]3[C:13]([c:12]2[cH:11]1)([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[N:63]([c:64]1[cH:69][cH:68][c:67]([cH:66][cH:65]1)-[c:70]1[cH:71][cH:72][cH:73][cH:74][cH:75]1)[c:60]1[cH:59][cH:58][c:57]([cH:62][cH:61]1)-[c:54]1[cH:55][cH:56][cH:51][cH:52][cH:53]1|US20160211456A1_0172
1.7.12|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[O&H1&+0&D1:2]-[c:1]>>[C&H2&+0&D2:5](-[O&H0&+0&D2:2]-[c:1])-[C&H2&+0&D2:4]-[C:3]|[CH2:1]=[CH:2][C:3]#[N:4].[CH3:5][N:6]([CH3:7])[c:8]1[cH:9][c:10]([cH:11][cH:12][cH:13]1)[OH:14]>CC(=O)O.[Na]>[CH3:5][N:6]([CH3:7])[c:8]1[cH:13][cH:12][cH:11][c:10]([cH:9]1)[O:14][CH2:1][CH2:2][C:3]#[N:4]|US20200247768A1_0564
1.2.9|[C:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[nH:8][c:9]1[c:10]2[CH2:11][CH:12]([CH2:13][CH2:14]1)O.[CH2:15]1[CH2:16][CH2:17][NH:18][CH2:19]1>COc1ccc2[nH]c3CCC(Cc3c2c1)O.Cc1cccc2c1[nH]c1c2CCCC1.Cc1cccc2c1[nH]c1c2CC(CC1)OS(=O)(=O)c1ccc(cc1)C.Cc1ccc(cc1)S(=O)(=O)OC1CCc2[nH]c3ccccc3c2C1>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[nH:8][c:9]1[c:10]2[CH2:11][CH:12]([CH2:13][CH2:14]1)[N:18]1[CH2:17][CH2:16][CH2:15][CH2:19]1|US20200131669A1_0838
2.5.7|[C&H3&D1:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[N:1])-S-C>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[N:1]|CS[C:1](=[N:2][CH2:3][CH2:4][S:5][CH2:6][c:7]1[n:8][cH:9][nH:10][c:11]1[CH3:12])[NH:13][C:14]#[N:15].[CH3:16][NH2:17]>CCO>[CH3:16][NH:17][C:1](=[N:2][CH2:3][CH2:4][S:5][CH2:6][c:7]1[n:8][cH:9][nH:10][c:11]1[CH3:12])[NH:13][C:14]#[N:15]|EP0169969A2_0045
9.5.3|[C&H3&D1:5]-[C&H0&+0&D4:4](-[C:3])(-[C&H2&+0&D2:2]-[C:1])-O>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[C:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[C:9]([CH3:10])([CH3:11])[C:12]([CH3:13])(O)[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[O:19][CH3:20]>CCOCC.CI.S=C=S.[K]>[CH3:20][O:19][c:5]1[cH:4][c:3]([cH:8][c:7]([cH:6]1)[C:9]([CH3:10])([CH3:11])[C:12]([CH3:13])=[CH:14][CH2:15][CH2:16][CH2:17][CH3:18])[O:2][CH3:1]|US10100056B2_0648
1.3.8|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][NH:14][CH:15]([CH2:16]1)[C:17](=[O:18])[OH:19].[O-:20][N+:21](=[O:22])[c:23]1[cH:24][cH:25][c:26]([n:27][c:28]1F)[F:29].Cl>CCN(CC)CC.CS(C)=O>[O-:20][N+:21](=[O:22])[c:23]1[cH:24][cH:25][c:26]([n:27][c:28]1[N:14]1[CH2:13][CH2:12][N:11]([CH2:16][CH:15]1[C:17](=[O:18])[OH:19])[C:2](=[O:1])[O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[F:29]|US20200140411A1_1118
7.9.4|[c:6]1:[c:5]:[o&H0&+0&D2:4]:[c:3]:[c:2]:[c&H0&+0&D3:1]:1=O>>[c:6]1:[c:5]-[O&H0&+0&D2:4]-[c:3]:[c:2]-[C&H2&+0&D2:1]-1|[CH3:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:15])[c:16]1[cH:17][cH:18][c:19]2[o:20][c:21]3[cH:22][cH:23][c:24]([cH:25][c:26]3[c:27]([c:28]2[cH:29]1)=O)[C:30](=[O:31])[NH:32][CH2:33][CH2:34][CH2:35][N:36]([CH2:37][CH2:38][CH2:39][CH3:40])[CH2:41][CH2:42][CH2:43][CH3:44]>[Pd]>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:15])[c:16]1[cH:17][cH:18][c:19]2[O:20][c:21]3[cH:22][cH:23][c:24]([cH:25][c:26]3[CH2:27][c:28]2[cH:29]1)[C:30](=[O:31])[NH:32][CH2:33][CH2:34][CH2:35][N:36]([CH2:37][CH2:38][CH2:39][CH3:40])[CH2:41][CH2:42][CH2:43][CH3:44]|US09657043B2_0562
3.11.86|[C:6]-[C&H2&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][C:6](=[O:7])[O:8][CH3:9].I[c:10]1[cH:11][cH:12][s:13][cH:14]1>O.[Na+].Cl.Br[Cu].c1cc2ccccc2nc1.[H-]>[CH3:1][O:2][C:3](=[O:4])[CH:5]([C:6](=[O:7])[O:8][CH3:9])[c:10]1[cH:11][cH:12][s:13][cH:14]1|US05180741A
1.2.6|[N&H2&+0&D1:5]-[N&H2&D1:4].[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[N&H0&+0&D2:5](-[N&H2&D1:4])=[C&H0&+0&D3:2](-[c:3])-[c:1]|O.[NH2:1][NH2:2].[NH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[C:10](=O)[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[Cl:17])[N+:18]([O-:19])=[O:20]>OCCOCCO>[NH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[C:10](=[N:2][NH2:1])[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[Cl:17])[N+:18]([O-:19])=[O:20]|US20180156811A1_0241
1.7.18|[C:5]-[O&H1&+0&D1:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[N&H1&+0&D1:3])-[c:1]|[ClH:1].[CH3:2][O:3][CH2:4][CH2:5][OH:6].[N:7]#[C:8][c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)[N+:15]([O-:16])=[O:17])[NH2:18]>>[ClH:1].[CH3:2][O:3][CH2:4][CH2:5][O:6][C:8](=[NH:7])[c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)[N+:15]([O-:16])=[O:17])[NH2:18]|US20200108083A1_0772
7.9.4|[c:6]1:[c:5]:[s&H0&+0&D2:4]:[c:3]:[c:2]:[c&H0&+0&D3:1]:1=O>>[c:6]1:[c:5]-[S&H0&+0&D2:4]-[c:3]:[c:2]-[C&H2&+0&D2:1]-1|[CH3:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][c:8]2[c:9]([c:10]3[cH:11][cH:12][cH:13][n:14][c:15]3[s:16][c:17]2[cH:18][cH:19]1)=O>Cl.C1COCCO1>[CH3:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:19][cH:18][c:17]2[S:16][c:15]3[n:14][cH:13][cH:12][cH:11][c:10]3[CH2:9][c:8]2[cH:7]1|US07049313B2_0362
9.7.41|[C&H0&-&D1:5]#[N&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[C-:1]#[N:2].Cl[c:3]1[cH:4][cH:5][c:6]2[n:7][c:8]([o:9][c:10]2[n:11]1)-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[Cu+]>CN1CCCC1=O>[N:2]#[C:1][c:3]1[cH:4][cH:5][c:6]2[n:7][c:8]([o:9][c:10]2[n:11]1)-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|EP2875003B1_0141
1.2.9|[c:6]-[C&H1&+0&D3:5](-[c:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|O[CH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[cH:20]1[cH:21][nH:22][cH:23][n:24]1>CC#N.O=S(c1ncc[nH]1)c1ncc[nH]1.O=S(Cl)Cl>[cH:20]1[cH:21][n:22]([cH:23][n:24]1)[CH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US20070249639A1_0348
7.6.1|[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][CH2:2][CH2:3][C:4]1=[C:5]([CH2:6][CH2:7][C:8]1=[O:9])[CH2:10][C:11](=[O:12])[O:13][CH3:14]>[H][H]>[CH3:1][CH2:2][CH2:3][CH:4]1[C:8]([CH2:7][CH2:6][CH:5]1[CH2:10][C:11](=[O:12])[O:13][CH3:14])=[O:9]|US08309511B1_0037
1.3.9|[c:6]:[c&H0&+0&D3:5](:[c:4])-I.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)I.[CH3:8][c:9]1[cH:10][cH:11][c:12]([nH:13][cH:14]1)=[O:15]>>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[n:13]1[cH:14][c:9]([cH:10][cH:11][c:12]1=[O:15])[CH3:8]|US10217946B2_0463
2.1.2|[N&H2&+0&D1:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=[O:12])O.[NH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[OH:20]>CC(C)COC(=O)Cl.CCN(CC)CC.c1ccncc1.C1CCOC1.O>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=[O:12])[NH:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[OH:20]|US08378108B2_1089
9.5.4|[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-O>>[C&H3&D1:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]|[CH3:1][CH2:2][C:3]1([c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH:10]=[CH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)O>CC(=O)Cl>[CH3:1][CH:2]=[C:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH:10]=[CH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]12|US09604978B2_0353
9.7.41|[C&H0&-&D1:5]#[N&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[C-:1]#[N:2].[O-:3][N+:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][c:10]([c:11]1Cl)[N+:12]([O-:13])=[O:14].[Cu+]>O.CN(C)C=O>[N:2]#[C:1][c:11]1[c:10]([cH:9][cH:8][cH:7][c:6]1[N+:4]([O-:3])=[O:5])[N+:12]([O-:13])=[O:14]|EP2709997B1_0231
1.3.8|[C:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1F.[cH:10]1[cH:11][cH:12][c:13]2[CH2:14][CH2:15][NH:16][c:17]2[cH:18]1>>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[N:16]1[CH2:15][CH2:14][c:13]2[cH:12][cH:11][cH:10][cH:18][c:17]21|US20200308163A1_0716
1.7.18|[C:5]-[O&H1&+0&D1:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[N:1]>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[N&H1&+0&D1:3])-[N:1]|[CH3:1][CH2:2][OH:3].[CH3:4][O:5][c:6]1[cH:7][c:8]2[c:9]([n:10][c:11]([n:12][c:13]2[cH:14][c:15]1[O:16][CH3:17])[N:18]1[CH2:19][CH2:20][N:21]([CH2:22][CH2:23]1)[C:24]#[N:25])[NH2:26]>CC(=O)O.[Na]>[CH3:1][CH2:2][O:3][C:24](=[NH:25])[N:21]1[CH2:20][CH2:19][N:18]([CH2:23][CH2:22]1)[c:11]1[n:12][c:13]2[cH:14][c:15]([c:6]([cH:7][c:8]2[c:9]([n:10]1)[NH2:26])[O:5][CH3:4])[O:16][CH3:17]|EP0159666B1_0042
9.5.4|[C&H3&D1:5]-[C&H0&+0&D4:4](-[c:3])(-[C&H2&+0&D2:2]-[C:1])-O>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[C:1]|[CH3:1][C:2](O)([CH2:3][C:4](=[O:5])[OH:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[F:19]>Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][C:2](=[CH:3][C:4](=[O:5])[OH:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[F:19]|US20120238549A1_0768
1.3.8|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1.[CH3:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1F>O.O[Na]>[CH3:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[N:5]1[CH2:4][CH2:3][N:2]([CH2:7][CH2:6]1)[CH3:1]|US07649001B2_1042
1.7.18|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[N&H1&+0&D1:1]|[ClH:1].[CH3:2][CH2:3][OH:4].[CH3:5][C:6]([CH3:7])([OH:8])[C:9]#[N:10]>CCOCC>[ClH:1].[CH3:2][CH2:3][O:4][C:9](=[NH:10])[C:6]([CH3:5])([CH3:7])[OH:8]|US20200131669A1_0469
1.7.12|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[C:2]-[O&H1&+0&D1:1]>>[C&H2&+0&D2:5](-[O&H0&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[C:3]|[CH2:1]=[CH:2][C:3]#[N:4].[OH:5][CH2:6][CH2:7][S:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>CCOC(C)=O.O=S(=O)(O)O.[Na]>[N:4]#[C:3][CH2:2][CH2:1][O:5][CH2:6][CH2:7][S:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|EP2655451B1_0112
1.3.8|[c:6]:[c&H0&+0&D3:5](:[c:4])-F.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[c:2]1[nH:3][n:4][c:5]2-[c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[O:12][c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3-[n:19]21.F[c:20]1[cH:21][cH:22][cH:23][c:24]([cH:25]1)[Cl:26]>O.CN(C)C=O.[H][H].[NaH]>[O:1]=[c:2]1[n:3]([n:4][c:5]2-[c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[O:12][c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3-[n:19]21)-[c:20]1[cH:25][c:24]([cH:23][cH:22][cH:21]1)[Cl:26]|EP1000059B1_0124
1.8.17|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[C:2]-[S&H1&+0&D1:1]>>[C&H2&+0&D2:5](-[S&H0&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[C:3]|[CH2:1]=[CH:2][C:3]#[N:4].[CH3:5][CH2:6][CH2:7][CH2:8][SH:9]>[Na+].C[O-]>[CH3:5][CH2:6][CH2:7][CH2:8][S:9][CH2:1][CH2:2][C:3]#[N:4]|US20180186752A1_0027
7.6.1|[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:3](-[C:2])-[N:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:3](-[C:2])-[N:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]1[C:6]([CH2:7][CH2:8][N:9]2[CH2:10][CH:11]([CH2:12][CH2:13][C:14]=12)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)=[O:21]>CCOCC.ClC(Cl)Cl.C1CCOC1.[Li+].[AlH4-]>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[C:6]([CH2:7][CH2:8][N:9]2[CH2:10][CH:11]([CH2:12][CH2:13][CH:14]12)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)=[O:21]|EP3325475B1_0454
1.2.17|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[c:3].[N&H2&+0&D1:2]-[c:1]>>[C&H2&+0&D2:5](-[N&H1&+0&D2:2]-[c:1])-[C&H2&+0&D2:4]-[c:3]|[CH2:1]=[CH:2][c:3]1[cH:4][cH:5][n:6][cH:7][cH:8]1.[NH2:9][c:10]1[cH:11][c:12]([cH:13][c:14]([c:15]1-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[S:22]([NH2:23])(=[O:24])=[O:25])[C:26](=[O:27])[OH:28]>O.CO.CC(=O)O>[NH2:23][S:22](=[O:24])(=[O:25])[c:14]1[cH:13][c:12]([cH:11][c:10]([c:15]1-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[NH:9][CH2:1][CH2:2][c:3]1[cH:4][cH:5][n:6][cH:7][cH:8]1)[C:26](=[O:27])[OH:28]|US20050038035A1_2194
10.4.15|[O&H0&D1:5]=[N&H0&+0&D2:4]-[O&-].[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&D1:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[O-][N:1]=[O:2].[OH:3][CH2:4][CH2:5][N:6]([CH2:7][CH2:8][OH:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>O.Cl>[O:2]=[N:1][c:13]1[cH:14][cH:15][c:10]([cH:11][cH:12]1)[N:6]([CH2:5][CH2:4][OH:3])[CH2:7][CH2:8][OH:9]|US20090286813A1_0140
3.11.91|[C&H3&+0&D1:5]-I.[C&H3&D1:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH3:6])[c:7]1[cH:8][cH:9][n:10][c:11]([cH:12]1)[O:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20].[CH3:21]I>C1CCOC1.[NaH]>[CH3:1][O:2][C:3](=[O:4])[C:5]([CH3:21])([CH3:6])[c:7]1[cH:8][cH:9][n:10][c:11]([cH:12]1)[O:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20]|US20070254917A1_0609
1.8.17|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[S&H1&+0&D1:2]-[c:1]>>[C&H2&+0&D2:5](-[S&H0&+0&D2:2]-[c:1])-[C&H2&+0&D2:4]-[C:3]|[CH2:1]=[CH:2][C:3]#[N:4].[SH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1>[Na+].C[O-]>[N:4]#[C:3][CH2:2][CH2:1][S:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1|US20120095048A1_0647
3.11.2|[C:6]-[C&H2&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:2](-[C:3])-[C:1]|[O:1]=[C:2]([OH:3])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](=[O:12])[CH2:13][CH:14]([OH:15])[C:16](=O)[CH:17]=[CH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[OH:25][K:26]>COC(=O)CC(=O)CCCCCCCC(=O)OC.CC(=O)C=Cc1ccccc1.O=CC(=O)C=Cc1ccccc1.O=C(O)CC(=O)CCCCCCCC(=O)O.O=[Se](O)O>[O:12]=[C:11]1[CH2:13][CH:14]([C:16](=[C:10]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:2](=[O:1])[OH:3])[CH:17]=[CH:18][c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1)[OH:15].[OH:25][K:26]|EP3187496A1_0283
1.8.17|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[c:3].[C:2]-[S&H1&+0&D1:1]>>[C&H2&+0&D2:5](-[S&H0&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[c:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[C:16](=[S:17])[SH:18].[CH2:19]=[CH:20][c:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1>Cc1ccccc1>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[C:16](=[S:17])[S:18][CH2:19][CH2:20][c:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1|US20200109112A1_0142
9.7.43|[N&H2&+0&D1:5]-[N&H2&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][n:3]1[c:4]([cH:5][n:6][c:7]1-[c:8]1[n:9][n:10][c:11]2[cH:12][cH:13][c:14]([n:15][n:16]12)Cl)[N+:17]([O-:18])=[O:19].[NH2:20][NH2:21].O>C1COCCO1.CO>[CH3:1][CH2:2][n:3]1[c:4]([cH:5][n:6][c:7]1-[c:8]1[n:9][n:10][c:11]2[cH:12][cH:13][c:14]([n:15][n:16]12)[NH:21][NH2:20])[N+:17]([O-:18])=[O:19]|US08889704B2_0859
2.1.1|[N&H2&+0&D1:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[O:9][CH3:10])[O:11][CH3:12])[C:13](=[O:14])Cl.[NH2:15][c:16]1[cH:17][c:18]([cH:19][cH:20][c:21]1[N:22]1[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1)[C:28](=[O:29])[c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>O.[Na+].CC(C)=O.[O-]C(=O)O>[CH3:10][O:9][c:8]1[c:7]([cH:6][c:5]([cH:4][c:3]1[O:2][CH3:1])[C:13](=[O:14])[NH:15][c:16]1[cH:17][c:18]([cH:19][cH:20][c:21]1[N:22]1[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1)[C:28](=[O:29])[c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)[O:11][CH3:12]|US06897231B2_0171
1.3.6|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[n:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[CH2:16][NH:17][CH3:18])Br.[cH:19]1[cH:20][n:21][nH:22][n:23]1>O=C(O[K])O[K].[Cu]>[CH3:18][NH:17][CH2:16][c:15]1[cH:14][c:13]([cH:12][cH:11][c:10]1[O:9][c:6]1[cH:7][cH:8][c:3]([cH:4][cH:5]1)[S:2][CH3:1])-[n:22]1[n:23][cH:19][cH:20][n:21]1|US10611760B2_0904
1.6.2|[C:6]-[C&H1&+0&D3:5](-[O:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H1&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH:7](Br)[O:8][c:9]1[cH:10][cH:11][cH:12][c:13]([n:14]1)[F:15].[cH:16]1[cH:17][nH:18][cH:19][n:20]1>C1CN=C2CCCCCN2C1.CC(C)=O>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH:7]([O:8][c:9]1[cH:10][cH:11][cH:12][c:13]([n:14]1)[F:15])[n:18]1[cH:17][cH:16][n:20][cH:19]1|US20200347090A1_1376
1.3.1|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1([c:12]2[cH:13][c:14]([cH:15][cH:16][c:17]2-[c:18]2[c:19]1[cH:20][c:21]([cH:22][cH:23]2)Br)[Br:24])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34].[cH:35]1[cH:36][cH:37][c:38]([cH:39][cH:40]1)[NH:41][c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1>Cc1ccccc1P(c1ccccc1C)c1ccccc1C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.Cc1ccccc1.CCCC[Li].[Pd]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1([c:12]2[cH:13][c:14]([cH:15][cH:16][c:17]2-[c:18]2[c:19]1[cH:20][c:21]([cH:22][cH:23]2)[N:41]([c:42]1[cH:47][cH:46][cH:45][cH:44][cH:43]1)[c:38]1[cH:37][cH:36][cH:35][cH:40][cH:39]1)[Br:24])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]|US20190378992A1_0730
2.1.11|[N&H2&+0&D1:5]-[n:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H1&+0&D2:5](-[n:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])Cl.[NH2:10][n:11]1[cH:12][c:13]([n:14][c:15]1[SH:16])-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>c1ccc(cc1)-c1cn2nc(sc2n1)SCc1ccccc1>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[NH:10][n:11]1[cH:12][c:13]([n:14][c:15]1[SH:16])-[c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|US08258130B2_0870
9.7.334|[c:5]1:[n&H0&+0&D2:4]:[c:3]:[n:2]:[n&H0&+0&D3:1]:1-C1-C-C-C-C-O-1>>[c:5]1:[n&H1&+0&D2:4]:[c:3]:[n:2]:[n&H0&+0&D2:1]:1|[Cl:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH2:8][c:9]1[n:10][c:11]([s:12][c:13]1-[c:14]1[n:15][cH:16][n:17]([n:18]1)C1CCCCO1)-[c:19]1[cH:20][cH:21][n:22][cH:23][cH:24]1>C1COCCO1.C1CCOC1.CO.Cl>[Cl:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH2:8][c:9]1[n:10][c:11]([s:12][c:13]1-[c:14]1[n:18][n:17][cH:16][nH:15]1)-[c:19]1[cH:20][cH:21][n:22][cH:23][cH:24]1|US09090601B2_0737
2.1.11|[N&H2&+0&D1:5]-[N:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[N&H1&+0&D2:5](-[N:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][N:2]([C:3](=[O:4])Cl)[CH:5]1[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[O:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]21.[CH3:19][N:20]([CH3:21])[NH2:22]>O.CCOCC.Cc1ccccc1>[CH3:1][N:2]([C:3](=[O:4])[NH:22][N:20]([CH3:19])[CH3:21])[CH:5]1[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[O:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]21|US20190185479A1_1698
3.11.91|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[O:1]=[C:2]([OH:3])[CH:4]1[CH2:5][CH2:6][CH2:7]1.[CH3:8][CH2:9][CH2:10][CH2:11]Br>CC(C)NC(C)C.CCCCCC.CCCC[Li].C1CCOC1.Cl>[CH3:8][CH2:9][CH2:10][CH2:11][C:4]1([CH2:5][CH2:6][CH2:7]1)[C:2](=[O:1])[OH:3]|US20200079784A1_0396
1.3.7|[c:6]:[c&H0&+0&D3:5](:[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH2:8])Cl.[CH3:9][c:10]1[n:11][cH:12][cH:13][nH:14]1>Cl.O=C(O[K])O[K].[Cu]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH2:8])-[n:14]1[cH:13][cH:12][n:11][c:10]1[CH3:9]|US20200140438A1_1555
3.11.91|[C:6]-[C&H1&+0&D3:5](-[O:4])-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:6]-[C&H0&+0&D4:5](-[O:4])(-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[CH2:9]Br)[O:10][CH3:11].[CH3:12][c:13]1[cH:14][cH:15][c:16]2[c:17]([cH:18]1)[CH:19]([C:20]([N:21]2[CH2:22][CH3:23])=[O:24])[O:25][C:26](=[O:27])[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>CCN1C(C(c2c1ccc(c2)C)(Cc1cc(c(c(c1)OC)OC)OC)OC(=O)c1ccccc1)=O>[CH3:23][CH2:22][N:21]1[C:20]([C:19]([c:17]2[c:16]1[cH:15][cH:14][c:13]([cH:18]2)[CH3:12])([CH2:9][c:7]1[cH:6][c:5]([cH:4][c:3]([cH:8]1)[O:2][CH3:1])[O:10][CH3:11])[O:25][C:26](=[O:27])[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)=[O:24]|US20190389899A1_1090
2.1.1|[N&H1&+0&D1:5]=[S:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[N&H0&+0&D2:5](=[S:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH2:7][S:8](=[NH:9])(=[O:10])[c:11]1[n:12][s:13][n:14][c:15]1-[n:16]1[cH:17][n:18][cH:19][cH:20]1.[O:21]=[C:22](Cl)[O:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>O=C(O[K])O[K].ClCCl>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH2:7][S:8](=[O:10])(=[N:9][C:22](=[O:21])[O:23][CH2:24][c:25]1[cH:30][cH:29][cH:28][cH:27][cH:26]1)[c:11]1[n:12][s:13][n:14][c:15]1-[n:16]1[cH:20][cH:19][n:18][cH:17]1|EP3016945B1_0382
1.3.7|[C:6]-[N&H1&+0&D2:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[c:15]1Cl)[C:16]([F:17])([F:18])[F:19].[CH3:20][O:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[S:28](=[O:29])(=[O:30])[NH:31][CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1>CN(C)C=O.O.Cl.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[c:15]1[N:31]([CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1)[S:28](=[O:29])(=[O:30])[c:25]1[cH:24][cH:23][c:22]([cH:27][cH:26]1)[O:21][CH3:20])[C:16]([F:17])([F:18])[F:19]|US08816079B2_3378
3.11.57|[C&H2&+0&D1:4]=[N&+]=[N&-].[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H2&+0&D2:4]1-[C&H2&+0&D2:3]-[C&H1&+0&D3:2]-1-[c:1]|[CH2:1]=[CH:2][c:3]1[c:4]([c:5]([c:6]([c:7]([c:8]1[F:9])[F:10])[C:11](=[O:12])[O:13][CH3:14])[F:15])[F:16].CCOCC.[CH2:17]=[N+]=[N-]>Cc1ccccc1C.CN(N=O)C(N)=O.CCOCC>[CH3:14][O:13][C:11](=[O:12])[c:6]1[c:7]([c:8]([c:3]([c:4]([c:5]1[F:15])[F:16])[CH:2]1[CH2:1][CH2:17]1)[F:9])[F:10]|US09073929B2_0235
1.3.6|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([C:3]1=[N:4][CH2:5][CH2:6][CH2:7][CH2:8][NH:9]1)[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1Br>O=C(O[K])O[K].c1ccccc1.CN(C)C=O.[O-2].[Cu+2]>[O:1]=[C:2]1[C:3]2=[N:4][CH2:5][CH2:6][CH2:7][CH2:8][N:9]2[c:15]2[cH:14][cH:13][cH:12][cH:11][c:10]12|EP2364975A1_0753
2.1.1|[N&H1&+0&D1:5]=[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H0&+0&D2:5](=[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([cH:7][c:8]1[O:9][CH3:10])[CH2:11][CH2:12][n:13]1[c:14]-2[c:15]([s:16][c:17]1=[NH:18])[C:19]#[N:20].[O:21]=[C:22](Cl)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>O.c1ccncc1>[CH3:10][O:9][c:8]1[cH:7][c:6]2[CH2:11][CH2:12][n:13]3[c:14]([c:15]([s:16][c:17]3=[N:18][C:22](=[O:21])[c:23]3[cH:28][cH:27][cH:26][cH:25][cH:24]3)[C:19]#[N:20])-[c:5]2[cH:4][c:3]1[O:2][CH3:1]|EP1820504A1_0126
1.6.4|[C:6]-[C&H1&+0&D3:5](-[O:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H1&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[F:1][CH:2]([F:3])[C:4]([F:5])([F:6])[S:7][c:8]1[n:9][c:10]([c:11]([nH:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.Cl[CH:25]1[CH2:26][CH2:27][CH2:28][O:29]1>CCN(CC)CC.O=S(=O)(Cl)Cl.C1CCOC1.O>[F:1][CH:2]([F:3])[C:4]([F:5])([F:6])[S:7][c:8]1[n:9][c:10]([c:11]([n:12]1[CH:25]1[CH2:26][CH2:27][CH2:28][O:29]1)-[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|US20180002366A1_0240
3.11.91|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H1&+0&D3:3](-[N:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[N:2])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6]Br.[O:7]=[C:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[C:15]([N:16]1[CH:17]1[C:18]([N:19]([c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]21)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)=[O:32])=[O:33]>CC(C)=O.O=C(O[K])O[K]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:17]1([C:18]([N:19]([c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]21)[c:26]1[cH:31][cH:30][cH:29][cH:28][cH:27]1)=[O:32])[N:16]1[C:15]([c:14]2[cH:13][cH:12][cH:11][cH:10][c:9]2[C:8]1=[O:7])=[O:33]|US08168667B2_0873
3.11.91|[C:6]-[C&H2&+0&D2:5]-Cl.[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[O:1]=[C:2]([F:3])[CH:4]([C:5](=[O:6])[F:7])[C:8]([F:9])([F:10])[F:11].[CH3:12][C:13]([CH3:14])=[CH:15][CH2:16]Cl>CCN(CC)CC.CCOCC>[CH3:12][C:13]([CH3:14])=[CH:15][CH2:16][C:4]([C:5](=[O:6])[F:7])([C:2](=[O:1])[F:3])[C:8]([F:9])([F:10])[F:11]|US20200199114A1_0782
1.3.2|[c:6]-[N&H1&+0&D2:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[cH:1]1[cH:2][cH:3][c:4]2[S:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[NH:12][c:13]2[cH:14]1.[Cl:15][c:16]1[n:17][c:18]([n:19][c:20]([n:21]1)[Cl:22])Cl>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.Cc1ccccc1.[Pd].[Pd]>[Cl:15][c:16]1[n:21][c:20]([n:19][c:18]([n:17]1)[N:12]1[c:13]2[cH:14][cH:1][cH:2][cH:3][c:4]2[S:5][c:6]2[c:11]1[cH:10][cH:9][cH:8][cH:7]2)[Cl:22]|EP2780325B1_0110
1.3.6|[C:6]-[N&H1&+0&D2:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([c:8]2[cH:9][cH:10][cH:11][n:12][c:13]2[c:14]1[O:15][S:16](=[O:17])(=[O:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[CH3:25])Br.[O:26]=[S:27]1([CH2:28][CH2:29][CH2:30][CH2:31][NH:32]1)=[O:33]>CN(C)C=O.c1cccc(n1)-c1ccccn1.O([Cu])[Cu]>[CH3:25][c:22]1[cH:23][cH:24][c:19]([cH:20][cH:21]1)[S:16](=[O:17])(=[O:18])[O:15][c:14]1[c:5]([n:6][c:7]([c:8]2[cH:9][cH:10][cH:11][n:12][c:13]12)[N:32]1[CH2:31][CH2:30][CH2:29][CH2:28][S:27]1(=[O:26])=[O:33])[C:3](=[O:4])[O:2][CH3:1]|EP3434671A1_0169
1.8.10|[C:5]-[S&H1&+0&D1:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C:5]-[S&H0&+0&D2:4]-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[F:1][C:2]([F:3])([C:4]([F:5])([F:6])[C:7]([F:8])([F:9])[CH2:10][CH2:11][SH:12])[C:13]([F:14])([F:15])[C:16]([F:17])([F:18])[C:19]([F:20])([F:21])[C:22]([F:23])([C:24]([F:25])([F:26])[F:27])[C:28]([F:29])([F:30])[F:31].[OH:32][CH2:33][CH:34]1[CH2:35][O:36]1>CO.C[O-].O.[Na+].Cl>[OH:32][CH2:33][CH:34]([OH:36])[CH2:35][S:12][CH2:11][CH2:10][C:7]([F:8])([F:9])[C:4]([F:5])([F:6])[C:2]([F:1])([F:3])[C:13]([F:14])([F:15])[C:16]([F:17])([F:18])[C:19]([F:20])([F:21])[C:22]([F:23])([C:24]([F:25])([F:26])[F:27])[C:28]([F:29])([F:30])[F:31]|US06762198B2
1.3.6|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[o:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[o:1]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([o:7]1)Br.[CH3:8][CH2:9][NH:10][CH2:11][CH3:12]>CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.CS(C)=O.[Cl-]>[CH3:8][CH2:9][N:10]([CH2:11][CH3:12])[c:6]1[cH:5][cH:4][c:3]([o:7]1)[CH:2]=[O:1]|US20180057505A1_0957
3.11.83|[C:6]-[C&H1&+0&D3:5](-[C:4])-[N:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[N:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]Cl.[CH3:19][C:20](=[O:21])[NH:22][CH:23]([C:24](=[O:25])[O:26][CH2:27][CH3:28])[C:29](=[O:30])[O:31][CH2:32][CH3:33]>[Na+].CC[O-].CCO>[CH3:33][CH2:32][O:31][C:29](=[O:30])[C:23]([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH:10]=[CH:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH3:1])([NH:22][C:20]([CH3:19])=[O:21])[C:24](=[O:25])[O:26][CH2:27][CH3:28]|US04435322A
1.3.7|[C:6]-[N&H1&+0&D2:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|Cl[c:1]1[n:2][c:3]([n:4][c:5]([n:6]1)[Cl:7])[Cl:8].[cH:9]1[cH:10][cH:11][c:12]2[CH2:13][CH2:14][NH:15][c:16]2[cH:17]1>O=P(O)(O)O.CC(C)=O.O[Na].O.Cl.[Na]>[Cl:8][c:3]1[n:4][c:5]([n:6][c:1]([n:2]1)[N:15]1[CH2:14][CH2:13][c:12]2[cH:11][cH:10][cH:9][cH:17][c:16]21)[Cl:7]|EP2571872B1_0151
1.3.6|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][cH:8][n:9][c:10]2Br)[nH:11]1.[cH:12]1[n:13][cH:14][nH:15][n:16]1>CN(C)C=O>[O:1]=[c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][cH:8][n:9][c:10]2-[n:15]2[cH:14][n:13][cH:12][n:16]2)[nH:11]1|US09434725B2_0460
3.11.83|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H1&+0&D3:3](-[C:2])-[N:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[N:1]|[CH3:1][C:2](=[O:3])[NH:4][CH:5]([C:6](=[O:7])[O:8][CH2:9][CH3:10])[C:11](=[O:12])[O:13][CH2:14][CH3:15].[CH3:16][CH2:17][O:18][C:19](=[O:20])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]Br>O.[Na+].CC[O-].I[Na].[Na]>[CH3:15][CH2:14][O:13][C:11](=[O:12])[C:5]([CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][C:19](=[O:20])[O:18][CH2:17][CH3:16])([NH:4][C:2]([CH3:1])=[O:3])[C:6](=[O:7])[O:8][CH2:9][CH3:10]|US07144906B2_0276
1.6.2|[C:6]-[C&H1&+0&D3:5](-[C:4])-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[F:9])[CH:10](Br)[CH2:11][CH2:12][Cl:13].[CH2:14]1[CH2:15][NH:16][CH2:17][CH2:18][O:19]1>c1ccccc1.I[K]>[O:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[F:9])[CH:10]([CH2:11][CH2:12][Cl:13])[N:16]1[CH2:17][CH2:18][O:19][CH2:14][CH2:15]1|US10604542B2_0667
1.3.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][N:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1.[CH3:8][C:9](=[O:10])[O:11][CH2:12][CH2:13][n:14]1[c:15]([cH:16][n:17][c:18]1-[c:19]1[n:20][n:21][c:22]2[cH:23][cH:24][c:25]([n:26][n:27]12)Cl)[N+:28]([O-:29])=[O:30]>C1COCCO1>[CH3:8][C:9](=[O:10])[O:11][CH2:12][CH2:13][n:14]1[c:18]([n:17][cH:16][c:15]1[N+:28]([O-:29])=[O:30])-[c:19]1[n:20][n:21][c:22]2[cH:23][cH:24][c:25]([n:26][n:27]21)[N:5]1[CH2:4][CH2:3][N:2]([CH2:7][CH2:6]1)[CH3:1]|US04661485A
1.3.6|[c:6]:[c&H0&+0&D3:5](:[s:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|Br.[NH2:1][c:2]1[n:3][cH:4][c:5]([s:6]1)Br.[cH:7]1[cH:8][nH:9][cH:10][n:11]1>CN(C)C=O.O=C(O[K])O[K]>[NH2:1][c:2]1[n:3][cH:4][c:5]([s:6]1)-[n:9]1[cH:8][cH:7][n:11][cH:10]1|US09388180B2_0380
3.11.91|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[C:7]([CH2:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21)=[O:15].[Br:16][CH2:17][CH2:18][CH2:19]Br>O.CCO.O[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1([C:7]([CH2:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21)=[O:15])[CH2:19][CH2:18][CH2:17][Br:16]|US20200230097A1_0339
3.11.91|[C:6]-[C&H1&+0&D3:5](-[C:4])-Br.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH2:7][CH2:8][C:9]([c:10]2[c:11]([c:12]1[CH3:13])[CH3:14])=[O:15].Br[CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20]1>COc1cc2CCC(C(c2c(c1Cl)Cl)=O)C1CCCC1.CI>[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH2:7][CH:8]([C:9]([c:10]2[c:11]([c:12]1[CH3:13])[CH3:14])=[O:15])[CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20]1|US10752586B1_0067
2.5.8|[C:5]-[N&H2&+0&D1:4].[N:3]=[C&H0&+0&D3:2](-[N:1])-O-c1:c:c:c:c:c:1>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[N:3])-[N:1]|[CH3:1][N:2]([CH2:3][c:4]1[cH:5][cH:6][c:7]([o:8]1)[CH2:9][S:10][CH2:11][CH2:12][N:13]=[C:14]([NH:15][S:16]([CH3:17])(=[O:18])=[O:19])Oc1ccccc1)[C:20](=[O:21])[C:22]([Cl:23])([Cl:24])[Cl:25].[NH2:26][CH2:27][CH:28]([OH:29])[c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[OH:36]>CCN(CC)CC.CCOC(C)=O.CC([O-])=O.CC#N.O.Cl.[K+]>[CH3:1][N:2]([CH2:3][c:4]1[cH:5][cH:6][c:7]([o:8]1)[CH2:9][S:10][CH2:11][CH2:12][N:13]=[C:14]([NH:26][CH2:27][CH:28]([OH:29])[c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[OH:36])[NH:15][S:16]([CH3:17])(=[O:18])=[O:19])[C:20](=[O:21])[C:22]([Cl:23])([Cl:24])[Cl:25]|US20190388421A1_1129
3.11.91|[C:6]-[C&H1&+0&D3:5](-[C:4])-[C:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][N:2]1[C:3]([CH2:4][CH:5]([CH2:6][C:7]1([CH3:8])[CH3:9])[N:10]([C:11](=[O:12])[CH:13]([CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[C:21](=[O:22])[OH:23])[CH:24]1[CH2:25][C:26]([N:27]([C:28]([CH2:29]1)([CH3:30])[CH3:31])[CH3:32])([CH3:33])[CH3:34])([CH3:35])[CH3:36].Br[CH2:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1>Cc1ccccc1.CN(C)C=O.[NaH]>[CH3:1][N:2]1[C:3]([CH2:4][CH:5]([CH2:6][C:7]1([CH3:8])[CH3:9])[N:10]([C:11](=[O:12])[C:13]([CH2:37][c:38]1[cH:43][cH:42][cH:41][cH:40][cH:39]1)([CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[C:21](=[O:22])[OH:23])[CH:24]1[CH2:25][C:26]([N:27]([C:28]([CH2:29]1)([CH3:30])[CH3:31])[CH3:32])([CH3:33])[CH3:34])([CH3:35])[CH3:36]|US06462074B1
1.6.2|[C:6]-[C&H1&+0&D3:5](-[C:4])-Br.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH:8][c:9]1[n:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[nH:17]1)[Cl:18].Br[CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23]1>CN(C)C=O.[NaH]>[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[N:8]([c:9]1[n:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[nH:17]1)[CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23]1)[Cl:18]|EP1592671B1_0071
1.3.6|[C:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][NH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[O-:10][N+:11](=[O:12])[c:13]1[cH:14][c:15]([cH:16][cH:17][c:18]1Br)[C:19](=[O:20])[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>>[CH3:1][CH2:2][N:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[c:18]1[cH:17][cH:16][c:15]([cH:14][c:13]1[N+:11]([O-:10])=[O:12])[C:19](=[O:20])[c:21]1[cH:26][cH:25][cH:24][cH:23][cH:22]1|EP3204360B1_0702
1.3.6|[C:6]-[C&H0&+0&D3:5](=[C:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H0&+0&D3:5](=[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]1[NH:3][C:4]([C:5](=[C:6]1[c:7]1[cH:8][nH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)Br)=[O:16].[cH:17]1[n:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[nH:25]1>CN(C)C=O.[NaH]>[O:1]=[C:2]1[NH:3][C:4]([C:5](=[C:6]1[c:7]1[cH:8][nH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)[n:25]1[cH:17][n:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]21)=[O:16]|US20160211456A1_0077
1.3.7|[C:6]-[N&H1&+0&D2:5]-[O:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][CH2:3][NH:4][c:5]1[n:6][c:7]([n:8][c:9]([n:10]1)Cl)[NH:11][CH2:12][CH2:13][CH3:14].[CH2:15]1[CH2:16][CH2:17][O:18][NH:19][CH2:20]1>CC(C)N(CC)C(C)C.C1CCOC1>[CH3:1][CH2:2][CH2:3][NH:4][c:5]1[n:6][c:7]([n:8][c:9]([n:10]1)[N:19]1[CH2:20][CH2:15][CH2:16][CH2:17][O:18]1)[NH:11][CH2:12][CH2:13][CH3:14]|EP3287454B1_0583
3.11.91|[C:6]-[C&H2&+0&D2:5]-Cl.[C:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[c:2])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]1[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[N:12]([c:13]2[cH:14][cH:15][c:16]([cH:17][c:18]21)[Cl:19])[CH3:20].[CH3:21][N:22]([CH3:23])[CH2:24][CH2:25]Cl>O.CC(C)(C)[O-].C1CCOC1.[K+]>[CH3:20][N:12]1[c:11]2[cH:10][cH:9][cH:8][cH:7][c:6]2[C:5]([c:18]2[cH:17][c:16]([cH:15][cH:14][c:13]21)[Cl:19])([CH2:25][CH2:24][N:22]([CH3:21])[CH3:23])[C:3](=[O:4])[O:2][CH3:1]|EP0018076A1_0049
3.11.91|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H1&+0&D3:3](-[C:2])-[O:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]1[O:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[CH2:13][CH2:14][C:15]1=[O:16].[Cl:17][CH2:18][CH2:19][CH2:20]Br>CC#N.O=C(O[K])O[K].I[K]>[CH3:1][O:2][C:3](=[O:4])[C:5]1([O:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[CH2:13][CH2:14][C:15]1=[O:16])[CH2:20][CH2:19][CH2:18][Cl:17]|US08569341B2_2489
2.4.5|[N&H2&+0&D1:5]-[S:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[N&H1&+0&D2:5](-[S:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])Cl.[NH2:6][S:7](=[O:8])(=[O:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16]>[Na+].[OH-]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[NH:6][S:7](=[O:8])(=[O:9])[c:10]1[cH:15][cH:14][c:13]([cH:12][cH:11]1)[Cl:16]|US07956054B2_0253
2.4.5|[N&H2&+0&D1:5]-[O:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[N&H1&+0&D2:5](-[O:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[NH2:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[Cl:9])[Cl:10].[O:11]=[C:12](Cl)[O:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>ClCCl.c1ccncc1>[O:11]=[C:12]([NH:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[Cl:9])[Cl:10])[O:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US20200297702A1_0678
1.3.6|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)Br.[cH:9]1[n:10][cH:11][nH:12][n:13]1>CN(C)C=O.O=C(O[K])O[K].Cl[Cu]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[n:12]1[cH:11][n:10][cH:9][n:13]1|EP3753938A1_0321
1.6.2|[C:6]-[C&H1&+0&D3:5](-[C:4])-Br.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH:4](Br)[C:5](=[O:6])[O:7][CH3:8].[O:9]=[C:10]1[CH2:11][N:12]=[C:13]([c:14]2[cH:15][c:16]([cH:17][cH:18][c:19]2[NH:20]1)[Br:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][n:27]1>O.[Na+].Cc1ccccc1.C[O-].CN(C)C=O>[CH3:1][CH2:2][CH2:3][CH:4]([C:5](=[O:6])[O:7][CH3:8])[N:20]1[C:10]([CH2:11][N:12]=[C:13]([c:14]2[cH:15][c:16]([cH:17][cH:18][c:19]21)[Br:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][n:27]1)=[O:9]|US20200377469A1_0439
9.7.26|[N&H2&+0&D1:5]-[N&H2&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][NH2:2].Br[c:3]1[n:4][cH:5][cH:6][cH:7][c:8]1-[c:9]1[cH:10][cH:11][cH:12][n:13][cH:14]1>c1ccncc1>[NH2:1][NH:2][c:3]1[n:4][cH:5][cH:6][cH:7][c:8]1-[c:9]1[cH:10][cH:11][cH:12][n:13][cH:14]1|US20190119251A1_0384
3.11.86|[C:6]-[C&H2&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([c:7]([c:8]2[nH:9][c:10]([n:11][c:12]12)[C:13]([F:14])([F:15])[F:16])Cl)[C:17]([F:18])([F:19])[F:20].[CH3:21][CH2:22][O:23][C:24](=[O:25])[CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31].[K]>>[CH3:31][CH2:30][O:29][C:27](=[O:28])[CH:26]([C:24](=[O:25])[O:23][CH2:22][CH3:21])[c:7]1[c:8]2[nH:9][c:10]([n:11][c:12]2[c:4]([cH:5][c:6]1[C:17]([F:18])([F:19])[F:20])[N+:2]([O-:1])=[O:3])[C:13]([F:14])([F:15])[F:16]|US05985909A
1.3.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[N:1]#[C:2][c:3]1[cH:4][c:5]([c:6]2[n:7][c:8]([nH:9][c:10]2[c:11]1Cl)[C:12]([F:13])([F:14])[F:15])[N+:16]([O-:17])=[O:18].[CH2:19]1[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1>>[N:1]#[C:2][c:3]1[cH:4][c:5]([c:6]2[n:7][c:8]([nH:9][c:10]2[c:11]1[N:22]1[CH2:23][CH2:24][CH2:19][CH2:20][CH2:21]1)[C:12]([F:13])([F:14])[F:15])[N+:16]([O-:17])=[O:18]|US10399957B2_0338
1.7.17|[C:5]-[O&H1&+0&D1:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C:5]-[O&H0&+0&D2:4]-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][OH:5].[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[CH2:15][O:16]1>[Na]>[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]([OH:16])[CH2:15][O:5][CH2:4][CH2:3][CH2:2][CH3:1]|US04020177A
3.11.93|[C&H3&+0&D1:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H2&+0&D2:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4]([CH3:5])=[O:6].[O:7]=[C:8](Cl)[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[I:15]>O.Cl.CCCCCC.CC(C)NC1CCCCC1.CCCC[Li].C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:6])[CH2:5][C:8](=[O:7])[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[I:15]|EP3212189B1_0534
3.11.91|[C:6]-[C&H1&+0&D3:5](-[C:4])-Br.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][CH2:13][c:14]1[cH:15][cH:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[n:23]1.Br[CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1>>[CH3:1][O:2][C:3](=[O:4])[CH:5]([c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][CH2:13][c:14]1[cH:15][cH:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[n:23]1)[CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1|EP2649045B1_0275
1.7.17|[N:5]-[O&H1&+0&D1:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[N:5]-[O&H0&+0&D2:4]-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[CH3:1][C:2](=[N:3][OH:4])[C@H:5]1[CH2:6][CH2:7][C@H:8]2[C:9]3=[CH:10][CH:11]=[C:12]4[CH2:13][C@H:14]([CH2:15][CH2:16][C@@:17]4([C@H:18]3[CH2:19][CH2:20][C@:21]12[CH3:22])[CH3:23])[O:24][CH:25]1[CH2:26][CH2:27][CH2:28][CH2:29][O:30]1.[CH3:31][C:32]1([CH2:33][O:34]1)[CH3:35]>CCOCC.CN(C)C=O.[NaH]>[CH3:23][C@@:17]12[CH2:16][CH2:15][C@@H:14]([CH2:13][C:12]2=[CH:11][CH:10]=[C:9]2[C@@H:18]1[CH2:19][CH2:20][C@:21]1([C@H:8]2[CH2:7][CH2:6][C@@H:5]1[C:2]([CH3:1])=[N:3][O:4][CH2:33][C:32]([CH3:31])([CH3:35])[OH:34])[CH3:22])[O:24][CH:25]1[CH2:26][CH2:27][CH2:28][CH2:29][O:30]1|US20050096360A1_0201
1.3.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][CH2:2][NH:3][CH2:4][CH3:5].[O-:6][N+:7](=[O:8])[c:9]1[cH:10][c:11]([c:12]([s:13]1)Cl)[N+:14]([O-:15])=[O:16]>CO>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[c:12]1[s:13][c:9]([cH:10][c:11]1[N+:14]([O-:15])=[O:16])[N+:7]([O-:6])=[O:8]|EP2913333A1_0144
9.7.307|[C:5]-[N&H0&+0&D3:4](-[C:3])-C.[N&H0&D1:2]#[C&H0&+0&D2:1]-Br>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[C&H0&+0&D2:1]#[N&H0&D1:2]|C[N:1]1[CH2:2][CH2:3][CH2:4][CH:5]([CH2:6]1)[CH2:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[F:16].[N:17]#[C:18]Br>c1ccccc1>[N:17]#[C:18][N:1]1[CH2:6][CH:5]([CH2:4][CH2:3][CH2:2]1)[CH2:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[F:16]|EP0536512A1_0028
1.6.4|[C:6]-[C&H1&+0&D3:5](-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[N:4]([C:5](=[O:6])[CH:7](Cl)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14])[CH:15]([CH3:16])[CH3:17].[cH:18]1[cH:19][nH:20][cH:21][n:22]1>CN(C)C=O.[NaH]>[CH3:1][CH:2]([CH3:3])[N:4]([C:5](=[O:6])[CH:7]([c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14])[n:20]1[cH:21][n:22][cH:18][cH:19]1)[CH:15]([CH3:16])[CH3:17]|US20150274665A1_0435
1.3.6|[C:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[o:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[o:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][n:8][c:9]([o:10]1)Br.[F:11][c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[O:18][C@H:19]1[CH2:20][CH2:21][NH:22][CH2:23]1)[Br:24]>C1CCOC1.C1CN=C2CCCCCN2C1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][n:8][c:9]([o:10]1)[N:22]1[CH2:21][CH2:20][C@@H:19]([CH2:23]1)[O:18][c:16]1[cH:17][c:12]([cH:13][cH:14][c:15]1[Br:24])[F:11]|EP3699173A1_0429
3.11.93|[C&H3&+0&D1:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H2&+0&D2:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C:2](=[O:3])[C:4](=[CH:5][N:6]([CH3:7])[CH3:8])[c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[C:15]([F:16])([F:17])[F:18].[CH3:19][C:20]([CH3:21])([CH3:22])[C:23](=[O:24])Cl>CC(C)NC(C)C.CCCCCC.CCCC[Li].C1CCOC1>[CH3:7][N:6]([CH3:8])[CH:5]=[C:4]([C:2](=[O:3])[CH2:1][C:23](=[O:24])[C:20]([CH3:19])([CH3:21])[CH3:22])[c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[C:15]([F:16])([F:17])[F:18]|US20190308973A1_0647
1.3.6|[c:6]:[n&H1&+0&D2:5]:[c:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[c:6]:[n&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH2:8][n:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[nH:16][c:17]1=[O:18].Br[c:19]1[n:20][c:21]([cH:22][s:23]1)[Br:24]>>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH2:8][n:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[n:16]([c:17]1=[O:18])-[c:19]1[n:20][c:21]([cH:22][s:23]1)[Br:24]|US20200165208A1_1146
1.3.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[o:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[o:1]|Br.Br.[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.Cl[c:14]1[n:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[o:22]1>CN(C)C=O.[O-]C([O-])=O.[K+].[K+]>[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[N:8]1[CH2:13][CH2:12][N:11]([CH2:10][CH2:9]1)[c:14]1[n:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[o:22]1|US07183290B2_0382
1.3.7|[c:6]:[n&H1&+0&D2:5]:[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[n&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|Cl[c:1]1[n:2][c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[nH:9]1)[CH2:10][n:11]1[cH:12][cH:13][n:14][cH:15]1.[cH:16]1[cH:17][nH:18][cH:19][n:20]1>CCO.O=C(O[K])O[K]>[cH:16]1[cH:17][n:18]([cH:19][n:20]1)-[c:1]1[n:2][c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[nH:9]1)[CH2:10][n:11]1[cH:12][cH:13][n:14][cH:15]1|US08541418B2_1092
2.3.11|[C:5]-[N&H2&+0&D1:4].[N:3]=[C&H0&+0&D3:2](-[O:1])-O-c1:c:c:c:c:c:1>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[N:3])-[O:1]|[CH3:1][C:2]1([O:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[C@H:10]([C@@H:11]1[OH:12])[NH2:13])[C:14]#[N:15])[CH3:16].[N:17]#[C:18][N:19]=[C:20]([O:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)Oc1ccccc1>CC(C)O>[CH3:1][C:2]1([O:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[C@H:10]([C@@H:11]1[OH:12])[NH:13][C:20](=[N:19][C:18]#[N:17])[O:21][c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1)[C:14]#[N:15])[CH3:16]|US08710050B2_0414
1.3.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][c:3]1[c:4]2[n:5][c:6]([n:7][c:8]([c:9]2[cH:10][c:11]([c:12]1[O:13][CH3:14])[O:15][CH3:16])[NH2:17])Cl.[CH3:18][O:19][c:20]1[cH:21][cH:22][c:23]2[CH2:24][CH2:25][NH:26][CH2:27][c:28]2[cH:29]1>>[CH3:18][O:19][c:20]1[cH:21][cH:22][c:23]2[CH2:24][CH2:25][N:26]([CH2:27][c:28]2[cH:29]1)[c:6]1[n:7][c:8]([c:9]2[cH:10][c:11]([c:12]([c:3]([c:4]2[n:5]1)[O:2][CH3:1])[O:13][CH3:14])[O:15][CH3:16])[NH2:17]|US20200407372A1_0705
3.3.3|[C&H1&+0&D1:5]#[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H0&+0&D2:5](#[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[Br:9].[CH:10]#[C:11][CH2:12][CH2:13][CH2:14][CH3:15]>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCN(CC)CC.I[Cu]>[CH3:15][CH2:14][CH2:13][CH2:12][C:11]#[C:10][C:2](=[O:1])[c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[Br:9]|EP2556073B1_0222
1.6.2|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[c:3])-[c:1]|[CH3:1][C:2]1([CH2:3][NH:4][CH2:5][CH2:6][NH:7]1)[CH2:8][c:9]1[cH:10][cH:11][c:12]2[O:13][CH2:14][CH2:15][O:16][c:17]2[cH:18]1.Br[CH:19]([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>CC(C)=O.O=C(O[K])O[K]>[CH3:1][C:2]1([CH2:3][N:4]([CH2:5][CH2:6][NH:7]1)[CH:19]([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:26]1[cH:31][cH:30][cH:29][cH:28][cH:27]1)[CH2:8][c:9]1[cH:10][cH:11][c:12]2[O:13][CH2:14][CH2:15][O:16][c:17]2[cH:18]1|US06355631B1
1.3.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|Cl[c:1]1[n:2][cH:3][cH:4][s:5]1.[cH:6]1[cH:7][cH:8][c:9]2[cH:10][cH:11][c:12]([cH:13][c:14]2[cH:15]1)[CH2:16][N:17]1[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]1>CN(C)C=O>[cH:3]1[cH:4][s:5][c:1]([n:2]1)[N:20]1[CH2:19][CH2:18][N:17]([CH2:22][CH2:21]1)[CH2:16][c:12]1[cH:11][cH:10][c:9]2[cH:8][cH:7][cH:6][cH:15][c:14]2[cH:13]1|US20090221604A1_0219
1.3.7|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|Cl[c:1]1[n:2][c:3]([c:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12)-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[Cl:17].[cH:18]1[cH:19][nH:20][cH:21][n:22]1>COCCOC.[NaH]>[Cl:17][c:3]1[n:2][c:1]([c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]2[c:4]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)-[n:20]1[cH:19][cH:18][n:22][cH:21]1|US09796712B2_1095
1.3.6|[c:6]:[c&H0&+0&D3:5](:[s:4])-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[cH:12][n:13][nH:14][c:15]([c:16]1-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23])=[O:24].[Cl:25][c:26]1[cH:27][cH:28][c:29]([s:30]1)Br>N>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[cH:12][n:13][n:14]([c:15]([c:16]1-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23])=[O:24])-[c:29]1[cH:28][cH:27][c:26]([s:30]1)[Cl:25]|US09562033B2_1120
3.11.91|[C:6]-[C&H1&+0&D3:5](-[C:4])-[O:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[O:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[C:9]([CH:10]([CH2:11][CH:12]1[CH2:13][O:14][Si:15]([CH3:16])([CH3:17])[C:18]([CH3:19])([CH3:20])[CH3:21])[O:22][C:23](=[O:24])[O:25][CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)=[O:33].[CH3:34][C:35]([CH3:36])([CH3:37])[O:38][C:39](=[O:40])[n:41]1[cH:42][c:43]([c:44]2[c:45]1[cH:46][cH:47][cH:48][cH:49]2)[CH2:50]Br>>[CH3:34][C:35]([CH3:36])([CH3:37])[O:38][C:39](=[O:40])[n:41]1[cH:42][c:43]([c:44]2[c:45]1[cH:46][cH:47][cH:48][cH:49]2)[CH2:50][C:10]1([CH2:11][CH:12]([N:8]([C:9]1=[O:33])[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[CH2:13][O:14][Si:15]([CH3:16])([CH3:17])[C:18]([CH3:19])([CH3:20])[CH3:21])[O:22][C:23](=[O:24])[O:25][CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1|US20190389899A1_0947
1.6.2|[c:6]-[C&H1&+0&D3:5](-[c:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|Br.[CH3:1][O:2][C:3](=[O:4])[NH:5][c:6]1[n:7][c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[nH:14]1)[CH:15](Br)[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22].[CH3:23][c:24]1[n:25][cH:26][cH:27][nH:28]1>O.CN(C)C=O>[CH3:1][O:2][C:3](=[O:4])[NH:5][c:6]1[n:7][c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[nH:14]1)[CH:15]([c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22])[n:28]1[cH:27][cH:26][n:25][c:24]1[CH3:23]|US20080188528A1_0482
1.6.4|[C:6]-[C&H1&+0&D3:5](-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][CH2:3][C:4]1([CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[CH2:10][CH:11](Cl)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[N:18]([C:19](=[O:20])[CH2:21][CH3:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[CH3:29][CH2:30][n:31]1[n:32][n:33][nH:34][c:35]1=[O:36]>O.CN(C)C=O.O=C(O[Na])O[Na].I[K]>[CH3:22][CH2:21][C:19](=[O:20])[N:18]([c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:4]1([CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[CH2:10][CH:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[n:34]1[n:33][n:32][n:31]([c:35]1=[O:36])[CH2:30][CH3:29])[CH2:3][O:2][CH3:1]|US20110201603A1_0452
1.3.7|[C:6]-[N&H1&+0&D2:5]-[N:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[N:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[N:16]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[c:24]1[n:25][c:26]([n:27][c:28]([c:29]1[F:30])Cl)[Cl:31].[CH3:32][N:33]1[CH2:34][CH2:35][N:36]([CH2:37][CH2:38]1)[NH:39][CH2:40][c:41]1[n:42][cH:43][cH:44][s:45]1>CCN(CC)CC.C1CCOC1.CS(C)=O>[CH3:32][N:33]1[CH2:34][CH2:35][N:36]([CH2:37][CH2:38]1)[N:39]([CH2:40][c:41]1[n:42][cH:43][cH:44][s:45]1)[c:28]1[n:27][c:26]([n:25][c:24]([c:29]1[F:30])[N:16]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[N:8]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[Cl:31]|US20130005707A1_1251
3.11.52|[C:6]-[C&H1&+0&D3:5](-[C:4])-[C:3].[n:2]-[C&H2&+0&D2:1]-Cl>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-[C&H2&+0&D2:1]-[n:2]|[N:1]#[C:2][CH:3]([C:4]#[N:5])[CH2:6][CH2:7][C:8]([F:9])([F:10])[F:11].Cl[CH2:12][n:13]1[cH:14][cH:15][cH:16][n:17]1.Cl>O=C(O[K])O[K].CN(C)C=O.O>[N:1]#[C:2][C:3]([C:4]#[N:5])([CH2:6][CH2:7][C:8]([F:9])([F:10])[F:11])[CH2:12][n:13]1[cH:14][cH:15][cH:16][n:17]1|US07541374B2_0587
3.11.91|[C:6]-[C&H1&+0&D3:5](-[C:4])-[C:3].[O:2]-[C&H2&+0&D2:1]-Cl>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-[C&H2&+0&D2:1]-[O:2]|[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]1[C:6]([N:7]([N:8]([C:9]1=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:23].[CH3:24][C:25]([CH3:26])([CH3:27])[C:28](=[O:29])[O:30][CH2:31]Cl>O=C(O[K])O[K].CC(C)=O>[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1([C:9]([N:8]([N:7]([C:6]1=[O:23])[c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1)[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1)=[O:10])[CH2:31][O:30][C:28](=[O:29])[C:25]([CH3:24])([CH3:26])[CH3:27]|US20200061068A1_0096
1.2.5|[C:6]-[C&H0&+0&D3:5](-[C:4])=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C@&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[C:8]1([CH2:9][N:10]2[C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]1.O=[C:23]1[CH2:24][C@H:25]2[CH2:26][CH2:27][C@@H:28]1[CH2:29]2>CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(=O)O.[Na+].Cl>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[C:8]1([CH2:22][CH2:21][N:20]([CH2:19][CH2:18]1)[C@H:23]1[CH2:24][C@H:25]3[CH2:26][CH2:27][C@@H:28]1[CH2:29]3)[CH2:9][N:10]2[C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17]|US20200121688A1_0242
2.1.11|[N&H2&+0&D1:5]-[N:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Br>>[N&H1&+0&D2:5](-[N:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH2:1][NH:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([cH:10]1)[O:11][CH2:12][c:13]1[cH:14][cH:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[cH:22]1)[N+:23]([O-:24])=[O:25].[O:26]=[C:27](Br)[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>CCN(CC)CC.CC(=O)N(C)C>[O-:24][N+:23](=[O:25])[c:7]1[cH:6][c:5]([cH:10][c:9]([cH:8]1)[O:11][CH2:12][c:13]1[cH:14][cH:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[cH:22]1)[C:3](=[O:4])[NH:2][NH:1][C:27](=[O:26])[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1|EP2030621A1_0238
2.4.5|[N&H2&+0&D1:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([n:6][c:7]1[C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[Cl:16].[CH3:17][CH2:18][O:19][C:20](=[O:21])Cl>c1ccncc1.C1COCCO1.O>[CH3:17][CH2:18][O:19][C:20](=[O:21])[NH:1][c:2]1[cH:3][cH:4][c:5]([n:6][c:7]1[C:8](=[O:9])[c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1)[Cl:16]|US07220727B2_0196
1.6.4|[C:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[S:6][c:7]3[cH:8][cH:9][c:10]([cH:11][c:12]3[CH:13]([CH2:14][c:15]2[cH:16]1)Cl)[F:17].[CH3:18][N:19]1[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1>c1ccccc1.O[Na].Cl>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[S:6][c:7]3[cH:8][cH:9][c:10]([cH:11][c:12]3[CH:13]([CH2:14][c:15]2[cH:16]1)[N:22]1[CH2:21][CH2:20][N:19]([CH2:24][CH2:23]1)[CH3:18])[F:17]|US20090099199A1_0420
1.3.1|[c:6]:[c&H0&+0&D3:5](:[s:4])-Br.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[CH3:8])[B:9]([c:10]1[c:11]([cH:12][c:13]([cH:14][c:15]1[CH3:16])[CH3:17])[CH3:18])[c:19]1[s:20][c:21]([c:22]2[c:23]1[cH:24][cH:25][cH:26][cH:27]2)Br)[CH3:28].[cH:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[NH:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.[Pd]>[CH3:18][c:11]1[cH:12][c:13]([cH:14][c:15]([c:10]1[B:9]([c:5]1[c:6]([cH:7][c:2]([cH:3][c:4]1[CH3:28])[CH3:1])[CH3:8])[c:19]1[s:20][c:21]([c:22]2[c:23]1[cH:24][cH:25][cH:26][cH:27]2)[N:35]([c:36]1[cH:41][cH:40][cH:39][cH:38][cH:37]1)[c:32]1[cH:31][cH:30][cH:29][cH:34][cH:33]1)[CH3:16])[CH3:17]|
3.11.91|[C:6]-[C&H2&+0&D2:5]-Cl.[C:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[c:1]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5]Cl.[CH3:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[CH:14]1[CH2:15][CH2:16][CH2:17][C:18]1=[O:19]>CCOCC.COCCOC.CC(C)(C)[O-].[K+]>[CH3:6][O:7][c:8]1[cH:13][cH:12][c:11]([cH:10][cH:9]1)[C:14]1([CH2:15][CH2:16][CH2:17][C:18]1=[O:19])[CH2:5][CH2:4][N:2]([CH3:1])[CH3:3]|US07923450B2_0329
1.3.1|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[cH:1]1[cH:2][cH:3][c:4]2[CH2:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[NH:12][c:13]2[cH:14]1.Br[c:15]1[cH:16][cH:17][cH:18][cH:19][n:20]1>CC(C)(C)P(C(C)(C)C)C(C)(C)C.Cc1ccccc1.CC(C)(C)[O-].CC([O-])=O.CC([O-])=O.ClCCl.[Na+].[Pd+2]>[cH:1]1[cH:2][cH:3][c:4]2[CH2:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[N:12]([c:13]2[cH:14]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][n:20]1|US09941479B2_0260
3.9.69|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H1&+0&D3:3](-[S:2])-[S:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[S:2])-[S:1]|Br[CH2:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[cH:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][CH2:17][CH2:18][CH:19]1[S:20][CH2:21][CH2:22][CH2:23][S:24]1>CCC(C)[Li].C1CCOC1>[cH:7]1[cH:8][cH:9][c:4]([cH:5][cH:6]1)[CH2:3][CH2:2][CH2:1][C:19]1([S:20][CH2:21][CH2:22][CH2:23][S:24]1)[CH2:18][CH2:17][CH2:16][c:13]1[cH:12][cH:11][cH:10][cH:15][cH:14]1|EP3134408B1_0302
3.11.86|[C:6]-[C&H2&+0&D2:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][S:6](=[O:7])(=[O:8])[CH2:9][CH2:10][C:11]([F:12])([F:13])[F:14].[F:15][C:16]([F:17])([F:18])[c:19]1[cH:20][n:21][c:22]([cH:23][cH:24]1)Cl>O=C(O[Cs])O[Cs].CS(C)=O.Cl>[CH3:1][O:2][C:3](=[O:4])[CH:5]([c:22]1[cH:23][cH:24][c:19]([cH:20][n:21]1)[C:16]([F:15])([F:17])[F:18])[S:6](=[O:7])(=[O:8])[CH2:9][CH2:10][C:11]([F:12])([F:13])[F:14]|US10059713B2_1095
1.3.6|[c:6]:[n&H1&+0&D2:5]:[n:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[c:6]:[n&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][c:2]1[c:3]([n:4][nH:5][c:6]1-[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[CH3:19][CH2:20][c:21]1[s:22][c:23]([n:24][c:25]1[C:26](=[O:27])[OH:28])Br>CN(C)[C@H]1CCCC[C@@H]1N.Cc1cc(cc(c1)C)C.O=P(O[K])(O[K])O[K].O.[I-].[I-].[Cu+2]>[CH3:1][c:2]1[c:3]([n:4][n:5]([c:6]1-[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)-[c:23]1[n:24][c:25]([c:21]([s:22]1)[CH2:20][CH3:19])[C:26](=[O:27])[OH:28])-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|EP3656770A2_0252
2.1.8|[N&H2&+0&D1:5]-[c:4].[O:3]-[C&H0&+0&D3:2](=[S&H0&D1:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](-[O:3])=[S&H0&D1:1]|[CH3:1][O:2][C:3](=[O:4])[NH:5][C:6](=[S:7])[NH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[NH2:15].[CH3:16][CH2:17][O:18][C:19](=[S:20])Cl>O.c1ccncc1>[CH3:16][CH2:17][O:18][C:19](=[S:20])[NH:15][c:14]1[cH:13][cH:12][cH:11][cH:10][c:9]1[NH:8][C:6](=[S:7])[NH:5][C:3](=[O:4])[O:2][CH3:1]|US20080058328A1_0550
3.11.86|[C:6]-[C&H2&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[c:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[c:9]2[n:10][c:11]3[cH:12][cH:13][cH:14][cH:15][n:16]3[c:17]2[n:18]1-[c:19]1[cH:20][cH:21][c:22]([n:23][cH:24]1)Br.[CH3:25][C:26]([CH3:27])([CH3:28])[O:29][C:30](=[O:31])[CH2:32][C:33]#[N:34]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.Cl[Pd]Cl.[NaH]>[CH3:25][C:26]([CH3:27])([CH3:28])[O:29][C:30](=[O:31])[CH:32]([C:33]#[N:34])[c:22]1[cH:21][cH:20][c:19]([cH:24][n:23]1)-[n:18]1[c:17]2[c:9]([n:10][c:11]3[cH:12][cH:13][cH:14][cH:15][n:16]32)[c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]2[c:2]1=[O:1]|US20200247784A1_0383
1.3.2|[c:6]:[c&H0&+0&D3:5](:[c:4])-Cl.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[NH:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[N:14]#[C:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)Cl>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.Cc1ccccc1.[Pd]>[N:14]#[C:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[N:7]([c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1)[c:4]1[cH:3][cH:2][cH:1][cH:6][cH:5]1|US20200212301A1_0161
3.3.3|[C&H1&+0&D1:5]#[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C&H0&+0&D2:5](#[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]12[O:10][CH2:11][C:12]([CH2:13][O:14]1)([CH2:15][O:16]2)[CH2:17][CH3:18].[CH3:19][CH2:20][O:21][C:22](=[O:23])Cl>CCCC[Li].C1CCOC1>[CH3:19][CH2:20][O:21][C:22](=[O:23])[C:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]12[O:16][CH2:15][C:12]([CH2:13][O:14]1)([CH2:11][O:10]2)[CH2:17][CH3:18]|EP2137193B1_0528
1.6.2|[C:6]-[C&H1&+0&D3:5](-[C:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Br)[CH:7]([CH3:8])[CH3:9].[cH:10]1[cH:11][nH:12][cH:13][n:14]1>CC#N>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH:7]([CH3:8])[CH3:9])[n:12]1[cH:11][cH:10][n:14][cH:13]1|US20200330458A1_0405
1.3.7|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][n:8][c:9]1Cl.[cH:10]1[n:11][cH:12][nH:13][n:14]1.[Na]>O.O.CN(C)C=O>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][n:8][c:9]1-[n:13]1[cH:12][n:11][cH:10][n:14]1|US20060148858A1_0637
1.3.7|[C:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]1[C:3]([CH2:4][C:5]([NH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]21)[C:13]([F:14])([F:15])[F:16])=[O:17])=[O:18].[O-:19][N+:20](=[O:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][c:27]1Cl>[O-]S([O-])(=O)=O.CC([O-])=O.ClCCl.[K+].[Cu+2]>[CH3:1][N:2]1[C:3]([CH2:4][C:5]([N:6]([c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]21)[C:13]([F:14])([F:15])[F:16])[c:27]1[cH:26][cH:25][cH:24][cH:23][c:22]1[N+:20]([O-:19])=[O:21])=[O:17])=[O:18]|EP3164397B1_0182
1.3.6|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][c:8]2[c:9]3[cH:10][c:11]([cH:12][cH:13][c:14]3[nH:15][c:16]2[CH2:17]1)[F:18].[F:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)Br>O.NCCN.O=C(O[Na])O[Na].Br[Cu]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][c:8]2[c:9]3[cH:10][c:11]([cH:12][cH:13][c:14]3[n:15]([c:16]2[CH2:17]1)-[c:23]1[cH:24][cH:25][c:20]([cH:21][cH:22]1)[F:19])[F:18]|US20100152160A1_0890
1.3.7|[C:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]1[CH2:8][NH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21.Cl[c:16]1[n:17][cH:18][n:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]21>COCCOC>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]1[CH2:8][N:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)[c:16]1[n:17][cH:18][n:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]21|US20200247822A1_0512
1.3.7|[C:6]=[C&H0&+0&D3:5](-[C:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]=[C&H0&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[O:4][C@@H:5]1[CH2:6][C:7]2=[CH:8][CH2:9][C@@H:10]3[C@H:11]([CH2:12][CH2:13][C@@:14]4([C:15](=[C:16]([CH2:17][C@@H:18]34)[CH:19]=[O:20])Cl)[CH3:21])[C@:22]2([CH2:23][CH2:24]1)[CH3:25].[cH:26]1[cH:27][nH:28][cH:29][n:30]1>CCCCCC.CCOC(C)=O.CN(C)C=O.[O-]C([O-])=O.[K+].[K+]>[CH3:1][C:2](=[O:3])[O:4][C@H:5]1[CH2:24][CH2:23][C@:22]2([C:7](=[CH:8][CH2:9][C@@H:10]3[C@@H:11]2[CH2:12][CH2:13][C@@:14]2([C:15](=[C:16]([CH2:17][C@@H:18]32)[CH:19]=[O:20])[n:28]2[cH:27][cH:26][n:30][cH:29]2)[CH3:21])[CH2:6]1)[CH3:25]|US20170008920A1_0203
1.3.6|[c:6]:[n&H1&+0&D2:5]:[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[c:6]:[n&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][c:2]1[n:3][n:4][c:5]([n:6]1-[c:7]1[c:8]([c:9]([cH:10][c:11]2[n:12][c:13]([c:14]([n:15][c:16]21)[O:17][CH3:18])[O:19][CH3:20])[Cl:21])[Cl:22])Br.[cH:23]1[cH:24][nH:25][cH:26][n:27]1>>[CH3:20][O:19][c:13]1[n:12][c:11]2[cH:10][c:9]([c:8]([c:7]([c:16]2[n:15][c:14]1[O:17][CH3:18])-[n:6]1[c:2]([n:3][n:4][c:5]1-[n:25]1[cH:24][cH:23][n:27][cH:26]1)[CH3:1])[Cl:22])[Cl:21]|US20200339550A1_0768
1.6.4|[c:6]-[C&H1&+0&D3:5](-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[Cl:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[CH:8](Cl)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[cH:21]1[cH:22][nH:23][cH:24][n:25]1>[Na+].C[O-].CC#N>[Cl:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[CH:8]([c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[n:23]1[cH:24][n:25][cH:21][cH:22]1|US20040067968A1_0264
1.3.1|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[OH:1][CH2:2][C@@H:3]([O:4][C@H:5]1[O:6][CH2:7][CH2:8][NH:9][C@H:10]1[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[F:17])[c:18]1[cH:19][c:20]([cH:21][c:22]([cH:23]1)[C:24]([F:25])([F:26])[F:27])[C:28]([F:29])([F:30])[F:31].[NH2:32][c:33]1[n:34][cH:35][c:36]([s:37]1)Br>Cc1ccccc1P(c1ccccc1C)c1ccccc1C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)(C)O[Na].C1COCCO1.[Pd].[Pd]>[NH2:32][c:33]1[n:34][cH:35][c:36]([s:37]1)[N:9]1[CH2:8][CH2:7][O:6][C@@H:5]([C@@H:10]1[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[F:17])[O:4][C@H:3]([CH2:2][OH:1])[c:18]1[cH:19][c:20]([cH:21][c:22]([cH:23]1)[C:24]([F:25])([F:26])[F:27])[C:28]([F:29])([F:30])[F:31]|US20200385375A1_0327
1.3.6|[C:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[NH2:1][c:2]1[n:3][n:4][c:5]([s:6]1)Br.[CH2:7]1[CH2:8][NH:9][CH2:10][CH2:11][O:12]1>CCO>[NH2:1][c:2]1[n:3][n:4][c:5]([s:6]1)[N:9]1[CH2:10][CH2:11][O:12][CH2:7][CH2:8]1|US20200283430A1_0435
1.3.6|[C:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][N:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1.Br[c:8]1[n:9][n:10][c:11]2[CH2:12][N:13]=[C:14]([c:15]3[cH:16][c:17]([cH:18][cH:19][c:20]3-[n:21]12)[Br:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][n:28]1>O.O=C(O)O[Na]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[c:8]1[n:9][n:10][c:11]2[CH2:12][N:13]=[C:14]([c:15]3[cH:16][c:17]([cH:18][cH:19][c:20]3-[n:21]21)[Br:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][n:28]1|EP2356123B1_0214
9.7.334|[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H0&+0&D3:1]:1-C1-C-C-C-C-O-1>>[c:5]1:[c:4]:[n&H1&+0&D2:3]:[c:2]:[n&H0&+0&D2:1]:1|[CH3:1][CH:2]([CH3:3])[CH2:4][N:5]([CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[n:14][cH:15][n:16][c:17]2[c:18]1[n:19][cH:20][n:21]2C1CCCCO1>N.O>[CH3:1][CH:2]([CH3:3])[CH2:4][N:5]([CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[n:14][cH:15][n:16][c:17]2[n:21][cH:20][nH:19][c:18]12|US09550781B2_0281
1.3.7|[C:6]-[N&H1&+0&D2:5]-[N:4].[N:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[N:4])-[C&H0&+0&D3:2](=[N:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[OH:9])/[CH:10]=[N:11]/[NH:12][CH2:13][CH2:14][OH:15].[O:16]=[S:17]1([N:18]=[C:19]([c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]21)Cl)=[O:26]>>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[OH:9])/[CH:10]=[N:11]/[N:12]([CH2:13][CH2:14][OH:15])[C:19]1=[N:18][S:17]([c:25]2[cH:24][cH:23][cH:22][cH:21][c:20]12)(=[O:16])=[O:26]|EP3632908A1_0237
2.3.9|[N&H2&+0&D1:5]-[c:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[O:1]=[C:2](Cl)[N:3]1[CH2:4][CH2:5][NH:6][C:7]1=[O:8].[NH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>CCN(CC)CC.C1CCOC1.O>[O:8]=[C:7]1[NH:6][CH2:5][CH2:4][N:3]1[C:2](=[O:1])[NH:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US05286736A
1.6.2|[C:6]-[C&H1&+0&D3:5](-[O:4])-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H1&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3]([CH3:4])([CH3:5])[C:6](=[O:7])[CH:8](Br)[O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[Cl:16])[Cl:17].[cH:18]1[n:19][cH:20][nH:21][n:22]1>CC(C)=O.C1=NCCCN2CCCCC12>[CH3:1][O:2][C:3]([CH3:4])([CH3:5])[C:6](=[O:7])[CH:8]([O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[Cl:16])[Cl:17])[n:21]1[cH:20][n:19][cH:18][n:22]1|US10570167B2_0955
9.7.43|[N&H2&+0&D1:5]-[N&H2&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|O.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[n:7][c:8]([n:9][c:10]([c:11]2[cH:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)Cl.[NH2:19][NH2:20]>CCO.CC(=O)O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[n:7][c:8]([n:9][c:10]([c:11]2[cH:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[NH:20][NH2:19]|US20200095261A1_0399
1.3.6|[C:6]-[N&H1&+0&D2:5]-[N:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[N:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|Cl.[CH3:1][CH2:2][CH2:3][NH:4][N:5]1[C:6]([CH2:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]21)=[O:14].Br[c:15]1[cH:16][cH:17][n:18][cH:19][cH:20]1>Oc1ccccc1.O[Na]>[CH3:1][CH2:2][CH2:3][N:4]([c:15]1[cH:20][cH:19][n:18][cH:17][cH:16]1)[N:5]1[C:6]([CH2:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]21)=[O:14]|EP2948439B1_0209
1.3.6|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][n:2]1[c:3]2[cH:4][cH:5][c:6]([n:7][c:8]2[nH:9][c:10]1=[O:11])[Cl:12].Br[c:13]1[cH:14][cH:15][cH:16][cH:17][n:18]1>CN(C)C=O.Cl[Cu].[NaH]>[CH3:1][n:2]1[c:3]2[cH:4][cH:5][c:6]([n:7][c:8]2[n:9]([c:10]1=[O:11])-[c:13]1[cH:14][cH:15][cH:16][cH:17][n:18]1)[Cl:12]|US08993765B2_0326
3.11.83|[C:6]-[C&H1&+0&D3:5](-[C:4])-[N:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[N:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2](=[O:3])[NH:4][CH:5]([C:6](=[O:7])[O:8][CH2:9][CH3:10])[C:11](=[O:12])[O:13][CH2:14][CH3:15].[O-:16][N+:17](=[O:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)-[c:25]1[cH:26][cH:27][c:28]([o:29]1)[CH2:30]Cl>CCO.[Na]>[CH3:15][CH2:14][O:13][C:11](=[O:12])[C:5]([CH2:30][c:28]1[cH:27][cH:26][c:25]([o:29]1)-[c:22]1[cH:21][cH:20][c:19]([cH:24][cH:23]1)[N+:17]([O-:16])=[O:18])([NH:4][C:2]([CH3:1])=[O:3])[C:6](=[O:7])[O:8][CH2:9][CH3:10]|US20060063707A1_0191
3.11.83|[C:6]-[C&H1&+0&D3:5](-[C:4])-[C:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH2:7][C:8](=[O:9])[O:10][CH2:11][CH3:12])[C:13](=[O:14])[O:15][CH2:16][CH3:17].[O-:18][N+:19](=[O:20])[c:21]1[cH:22][cH:23][cH:24][cH:25][c:26]1[CH2:27]Cl>c1ccccc1.CN(C)C=O.CC#N.[Na+].[H-]>[CH3:12][CH2:11][O:10][C:8](=[O:9])[CH2:7][C:6]([CH2:27][c:26]1[cH:25][cH:24][cH:23][cH:22][c:21]1[N+:19]([O-:18])=[O:20])([C:13](=[O:14])[O:15][CH2:16][CH3:17])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20200317667A1_1279
1.2.14|[C:5]-[N&H2&+0&D1:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C:5]-[N&H1&+0&D2:4]-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[CH2:1]=[CH:2][CH2:3][O:4][CH2:5][CH:6]1[CH2:7][O:8]1.[CH3:9][CH2:10][CH2:11][NH2:12]>CCO>[CH2:1]=[CH:2][CH2:3][O:4][CH2:5][CH:6]([OH:8])[CH2:7][NH:12][CH2:11][CH2:10][CH3:9]|EP0400519A1_0129
1.3.6|[C:6]-[N&H1&+0&D2:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][c:9]([n:10]1[CH2:11][C:12](=[O:13])[NH:14][c:15]1[c:16]([cH:17][c:18]([cH:19][c:20]1[CH3:21])[CH3:22])[CH3:23])Br)[CH3:24]>[O-]C([O-])=O.O=S1(CCCC1)=O.[Ag+].[Ag+]>[CH3:22][c:18]1[cH:19][c:20]([c:15]([c:16]([cH:17]1)[CH3:23])[N:14]1[C:12]([CH2:11][n:10]2[c:6]([c:7]([n:8][c:9]12)[CH3:24])[C:4](=[O:5])[O:3][CH2:2][CH3:1])=[O:13])[CH3:21]|US20170101409A1_0416
3.11.16|[C&H3&D1:5]-[C&H2&+0&D2:4]-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[c:4]([cH:5][cH:6][c:7]([c:8]1[C:9](=[O:10])[OH:11])Br)[O:12][CH3:13].[CH3:14][CH2:15]I>Cl.CCCC[Li].C1CCOC1>[CH3:14][CH2:15][c:7]1[cH:6][cH:5][c:4]([c:3]([c:8]1[C:9](=[O:10])[OH:11])[O:2][CH3:1])[O:12][CH3:13]|US20060257987A1_0550
3.11.83|[C:6]-[C&H1&+0&D3:5](-[C:4])-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[O:18][CH3:19].Br[CH2:20][c:21]1[cH:22][c:23]2[cH:24][c:25]([cH:26][cH:27][c:28]2[s:29]1)[Br:30]>[NH4+].[Cl-].C1CCOC1.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH2:20][c:21]1[cH:22][c:23]2[cH:24][c:25]([cH:26][cH:27][c:28]2[s:29]1)[Br:30])([C:7](=[O:8])[O:9][CH2:10][CH3:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[O:18][CH3:19]|EP2257545B1_0141
2.1.11|[N&H2&+0&D1:5]-[N:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H1&+0&D2:5](-[N:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C:6]([NH:7][C:8]2([CH2:9][C:10]([N:11]([C:12]([CH2:13]2)([CH3:14])[CH3:15])[NH2:16])([CH3:17])[CH3:18])[C:19]1=[O:20])=[O:21].[O:22]=[C:23](Cl)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>CCN(CC)CC.c1ccccc1>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C:6]([NH:7][C:8]2([CH2:9][C:10]([N:11]([C:12]([CH2:13]2)([CH3:14])[CH3:15])[NH:16][C:23](=[O:22])[c:24]2[cH:29][cH:28][cH:27][cH:26][cH:25]2)([CH3:17])[CH3:18])[C:19]1=[O:20])=[O:21]|EP3118200A1_0486
1.6.4|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[c:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH2:11][C:12]1([CH2:13][NH:14][CH2:15][CH2:16][NH:17]1)[CH3:18].[Cl:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[CH:26](Cl)[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>CCC(C)=O>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH2:11][C:12]1([CH2:13][N:14]([CH2:15][CH2:16][NH:17]1)[CH:26]([c:27]1[cH:32][cH:31][cH:30][cH:29][cH:28]1)[c:23]1[cH:24][cH:25][c:20]([cH:21][cH:22]1)[Cl:19])[CH3:18]|US20180312482A1_0280
1.3.6|[C:6]-[C&H0&+0&D3:5](=[C:4])-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][N:2]1[C:3]([C:4](=[C:5]([C:6]1=[O:7])Br)[Br:8])=[O:9].[CH2:10]1[CH2:11][NH:12][CH2:13][CH2:14][O:15]1>CN(C)C=O.[O-]C([O-])=O.[Cs+].[Cs+]>[CH3:1][N:2]1[C:3]([C:4](=[C:5]([C:6]1=[O:7])[N:12]1[CH2:13][CH2:14][O:15][CH2:10][CH2:11]1)[Br:8])=[O:9]|US20150306069A1_0196
3.11.91|[C:6]-[C&H1&+0&D3:5](-[c:4])-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:6]-[C&H0&+0&D4:5](-[c:4])(-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][N:2]1[C:3]([CH:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21)[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[O:17][CH3:18])=[O:19].Br[CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>CC(C)(C)[O-].C1CCOC1.[K+]>[CH3:18][O:17][c:16]1[cH:15][cH:14][cH:13][cH:12][c:11]1[C:4]1([C:3]([N:2]([c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]21)[CH3:1])=[O:19])[CH2:20][c:21]1[cH:26][cH:25][cH:24][cH:23][cH:22]1|EP1954668B1_0551
1.6.2|[C:6]-[C&H1&+0&D3:5](-[c:4])-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5](Br)[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1.[cH:12]1[n:13][cH:14][nH:15][n:16]1>O=C(O[K])O[K]>[CH3:1][O:2][C:3](=[O:4])[CH:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[n:15]1[cH:14][n:13][cH:12][n:16]1|EP3510026B1_0336
1.3.7|[C:6]-[N&H1&+0&D2:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH:3]([CH3:4])[NH:5][c:6]1[cH:7][c:8]([cH:9][c:10]([n:11]1)Cl)[C:12](=[O:13])[O:14][CH3:15].[O:16]=[S:17]1([CH2:18][CH2:19][CH2:20][CH2:21][NH:22]1)=[O:23]>CC(C)(C)P(c1ccccc1-c1ccccc1)C(C)(C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.Cc1ccccc1.[Na].[Pd].[Pd]>[CH3:15][O:14][C:12](=[O:13])[c:8]1[cH:7][c:6]([n:11][c:10]([cH:9]1)[N:22]1[CH2:21][CH2:20][CH2:19][CH2:18][S:17]1(=[O:16])=[O:23])[NH:5][CH:3]([CH3:4])[CH2:2][CH3:1]|EP3293184B1_0309
1.3.7|[c:6]:[c&H0&+0&D3:5](:[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([n:7][c:8]([c:9]([c:10]1Cl)[C:11](=[O:12])[O:13][CH2:14][CH3:15])[C:16]([F:17])([F:18])[F:19])[CH:20]([F:21])[F:22].[cH:23]1[cH:24][cH:25][nH:26][n:27]1>CCCC[Li].c1cc[nH]n1.C1CCOC1.O.[Li]>[CH3:15][CH2:14][O:13][C:11](=[O:12])[c:9]1[c:8]([n:7][c:6]([c:5]([c:10]1-[n:26]1[cH:25][cH:24][cH:23][n:27]1)[C:3](=[O:4])[O:2][CH3:1])[CH:20]([F:21])[F:22])[C:16]([F:17])([F:18])[F:19]|US10844016B2_1042
1.3.7|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[n:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[n&H0&+0&D3:2](:[n:3]):[n:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][c:8]([c:9]1[O:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[O:18][CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)-[c:26]1[n:27][n:28][nH:29][n:30]1.[F:31][C:32]([F:33])([F:34])[c:35]1[cH:36][n:37][c:38]([cH:39][cH:40]1)Cl>O=C(O[K])O[K].CC#N.ClCCl>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][c:8]([c:9]1[O:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[O:18][CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)-[c:26]1[n:27][n:28][n:29]([n:30]1)-[c:38]1[cH:39][cH:40][c:35]([cH:36][n:37]1)[C:32]([F:31])([F:33])[F:34]|US20200270247A1_0931
1.6.2|[C:6]-[C&H1&+0&D3:5](-[c:4])-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]([CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1.[CH3:17][C:18](=[O:19])[CH:20](Br)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>CCC(C)=O.O=C(O[K])O[K]>[CH3:17][C:18](=[O:19])[CH:20]([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[N:14]1[CH2:15][CH2:16][N:11]([CH2:12][CH2:13]1)[CH:2]([CH3:1])[CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|US08691836B2_0248
1.3.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[o:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[o:1]|[OH:1][CH2:2][CH2:3][N:4]1[CH2:5][CH2:6][NH:7][CH2:8][CH2:9]1.Cl[c:10]1[o:11][n:12][c:13]2[c:14]1[CH2:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1-2>CO.CCOC(C)=O.CN1CCCC1=O.O=[K]O[K]=O.ClCCl.ClC(Cl)Cl>[OH:1][CH2:2][CH2:3][N:4]1[CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[c:10]1[o:11][n:12][c:13]2-[c:22]3[cH:21][cH:20][cH:19][cH:18][c:17]3[CH2:16][CH2:15][c:14]21|US20190330198A1_1081
3.11.86|[C:6]-[C&H2&+0&D2:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][c:8]([cH:9][cH:10][c:11]1[Cl:12])[C@@H:13]1[O:14][C@@H:15]([C@H:16]([C@@H:17]([C@H:18]1[O:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[O:27][CH2:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)[O:35][CH2:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[CH2:43][O:44][CH2:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1.[CH3:52][c:53]1[cH:54][cH:55][c:56]2[n:57][c:58]([n:59][n+:60]([c:61]2[cH:62]1)[O-:63])Cl>CN(C)C=O.[NaH]>[CH3:52][c:53]1[cH:54][cH:55][c:56]2[n:57][c:58]([n:59][n+:60]([c:61]2[cH:62]1)[O-:63])[CH:5]([C:3](=[O:4])[O:2][CH3:1])[c:6]1[cH:7][c:8]([cH:9][cH:10][c:11]1[Cl:12])[C@@H:13]1[O:14][C@@H:15]([C@H:16]([C@@H:17]([C@H:18]1[O:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[O:27][CH2:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)[O:35][CH2:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[CH2:43][O:44][CH2:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1|US20150126737A1_0268
3.2.6|[C&H2&+0&D1:5]=[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H1&+0&D2:5](=[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH2:1]=[C:2]([Cl:3])[Cl:4].[CH3:5][CH:6]([CH3:7])[C:8](=[O:9])Cl>O.[Cl-].[Cl-].[Cl-].ClCCl.[Fe+3]>[CH3:5][CH:6]([CH3:7])[C:8](=[O:9])[CH:1]=[C:2]([Cl:3])[Cl:4]|US09102623B2_0594
3.11.57|[C&H2&+0&D1:4]=[C&H1&+0&D2:3]-[C:2].[C&H2&+0&D1:1]=[N&+]=[N&-]>>[C&H2&+0&D2:4]1-[C&H2&+0&D2:1]-[C&H1&+0&D3:3]-1-[C:2]|[CH2:1]=[CH:2][CH2:3][c:4]1[c:5]([cH:6][cH:7][c:8]2[c:9]([n:10][o:11][c:12]21)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[OH:19].[CH2:20]=[N+]=[N-]>CCOCC.CC(=O)O[Pd]OC(C)=O>[OH:19][c:5]1[cH:6][cH:7][c:8]2[c:9]([n:10][o:11][c:12]2[c:4]1[CH2:3][CH:2]1[CH2:1][CH2:20]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US20070249670A1_1435
1.6.2|[C:6]-[C&H1&+0&D3:5](-[c:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5](Br)[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1.[cH:12]1[cH:13][nH:14][cH:15][n:16]1>CC(C)=O.O=C(O[K])O[K]>[CH3:1][O:2][C:3](=[O:4])[CH:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[n:14]1[cH:15][n:16][cH:12][cH:13]1|EP3510022B1_0171
1.3.6|[c:6]:[n&H1&+0&D2:5]:[n:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[c:6]:[n&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][n:2]1[c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[c:9]2[c:10]([n:11][nH:12][c:13]([c:14]21)=[O:15])[C:16](=[O:17])[N:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1)[F:23].Br[c:24]1[n:25][cH:26][cH:27][cH:28][n:29]1>CN(C)C=O.O=C(O[K])O[K].I[Cu]>[CH3:1][n:2]1[c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[c:9]2[c:10]([n:11][n:12]([c:13]([c:14]21)=[O:15])-[c:24]1[n:29][cH:28][cH:27][cH:26][n:25]1)[C:16](=[O:17])[N:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1)[F:23]|US20200283446A1_0370
3.2.5|[C&H2&+0&D1:5]=[C&H2&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H1&+0&D2:5](=[C&H2&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1Br)[C:8]([F:9])([F:10])[F:11].[CH2:12]=[CH2:13]>Cc1ccccc1P(c1ccccc1C)c1ccccc1C.CCN(CC)CC.CCOCC.CC([O-])=O.CC#N>[CH2:13]=[CH:12][c:7]1[cH:6][cH:5][cH:4][c:3]([c:2]1[CH3:1])[C:8]([F:9])([F:10])[F:11]|EP1390356B1_0087
1.6.4|[C:6]-[C&H1&+0&D3:5](-[C:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])-[c:16]1[n:17][nH:18][c:19]2[n:20][cH:21][cH:22][cH:23][c:24]12.[O:25]=[C:26]1[O:27][CH2:28][CH:29]([CH2:30][O:31]1)Cl>>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])-[c:16]1[n:17][n:18]([c:19]2[n:20][cH:21][cH:22][cH:23][c:24]12)[CH:29]1[CH2:30][O:31][C:26]([O:27][CH2:28]1)=[O:25]|US07402680B2_0877
1.3.7|[C:6]-[N&H1&+0&D2:5]-[O:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][c:7]2[c:8]([n:9][n:10][n:11]2[CH2:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[Cl:19])[c:20]([n:21]1)Cl.[CH2:22]1[CH2:23][CH2:24][O:25][NH:26][CH2:27]1>CC(C)(C)c1nc2c(nnn2Cc2ccccc2Cl)c(n1)N1CCOCC1>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][c:7]2[c:8]([n:9][n:10][n:11]2[CH2:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[Cl:19])[c:20]([n:21]1)[N:26]1[CH2:27][CH2:22][CH2:23][CH2:24][O:25]1|EP3287454B1_0587
1.6.2|[C:6]-[N&H1&+0&D2:5]-[c:4].[c:3]-[C&H1&+0&D3:2](-[c:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[C&H1&+0&D3:2](-[c:3])-[c:1]|Br[CH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[cH:14]1[cH:15][cH:16][c:17]2[CH2:18][CH2:19][NH:20][c:21]2[cH:22]1>Cc1ccccc1.O=C(O[K])O[K].ClC(c1ccccc1)c1ccccc1>[cH:11]1[cH:12][cH:13][c:8]([cH:9][cH:10]1)[CH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:20]1[CH2:19][CH2:18][c:17]2[cH:16][cH:15][cH:14][cH:22][c:21]21|US08263606B2_1555
1.3.1|[C:6]-[N&H1&+0&D2:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C@@H:11]([CH2:12]1)[NH:13][c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[Cl:20])[Cl:21].Br[c:22]1[n:23][cH:24][cH:25][s:26]1>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.Cc1ccccc1.CC(C)(C)O[Na].F[B-](F)(F)F.[Pd].[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C@@H:11]([CH2:12]1)[N:13]([c:22]1[n:23][cH:24][cH:25][s:26]1)[c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[Cl:20])[Cl:21]|US08987250B2_1271
1.3.6|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][c:2]1[n:3][cH:4][c:5]([n:6][c:7]1Br)[Br:8].[CH2:9]1[CH2:10][NH:11][CH2:12][CH2:13][O:14]1>>[NH2:1][c:2]1[n:3][cH:4][c:5]([n:6][c:7]1[N:11]1[CH2:12][CH2:13][O:14][CH2:9][CH2:10]1)[Br:8]|US20200399268A1_0991
1.3.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[N:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[N:1]|[CH3:1][C:2]1([C:3](=[N:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[C:11]1([OH:12])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)Cl)[CH3:19].[CH3:20][N:21]1[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]1>CCN(CC)CC.C1COCCO1>[CH3:20][N:21]1[CH2:22][CH2:23][N:24]([CH2:25][CH2:26]1)[C:3]1=[N:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[C:11]([C:2]1([CH3:1])[CH3:19])([OH:12])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|EP2099748B1_0204
1.3.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[C:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[C:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10][O:11][C:12](=[O:13])[C:14]1=[C:15]([CH2:16][S:17][C@@H:18]2[CH:19]([C:20]([N:21]12)=[O:22])[NH:23][C:24](=[O:25])[CH2:26][c:27]1[cH:28][cH:29][cH:30][s:31]1)Cl.[CH2:32]1[CH2:33][CH2:34][NH:35][CH2:36]1>O.[Na+].[Cl-].CCOC(C)=O.CN(C)C=O>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10][O:11][C:12](=[O:13])[C:14]1=[C:15]([CH2:16][S:17][C@@H:18]2[CH:19]([C:20]([N:21]12)=[O:22])[NH:23][C:24](=[O:25])[CH2:26][c:27]1[cH:28][cH:29][cH:30][s:31]1)[N:35]1[CH2:34][CH2:33][CH2:32][CH2:36]1|US20150306069A1_0189
2.1.11|[N&H2&+0&D1:5]-[n:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[N&H1&+0&D2:5](-[n:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])Cl.[NH2:6][n:7]1[cH:8][cH:9][cH:10][c:11]1[C:12](=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>O=C(O)O[Na].ClCCl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[NH:6][n:7]1[cH:8][cH:9][cH:10][c:11]1[C:12](=[O:13])[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|US10227344B2_0487
3.11.83|[C:6]-[C&H1&+0&D3:5](-[C:4])-[N:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[N:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([NH:7][C:8]([CH3:9])=[O:10])[C:11](=[O:12])[O:13][CH2:14][CH3:15].[N:16]#[C:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[CH2:24]Br>CC(C)(C)O[K].CC(C)(C)O[K].CN(C)C=O.O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH2:24][c:21]1[cH:20][cH:19][c:18]([cH:23][cH:22]1)[C:17]#[N:16])([NH:7][C:8]([CH3:9])=[O:10])[C:11](=[O:12])[O:13][CH2:14][CH3:15]|US20200199114A1_0693
1.6.2|[C:6]-[C&H0&+0&D3:5](=[N:4])-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[N:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][NH:2][C:3](=[O:4])[CH:5]([C:6](Br)=[N:7][OH:8])[C:9]([CH3:10])([CH3:11])[CH3:12].[CH2:13]1[CH2:14][CH2:15][NH:16][CH2:17]1>CCOCC>[CH3:1][NH:2][C:3](=[O:4])[CH:5]([C:6](=[N:7][OH:8])[N:16]1[CH2:15][CH2:14][CH2:13][CH2:17]1)[C:9]([CH3:10])([CH3:11])[CH3:12]|US20200129627A1_1921
1.3.7|[c:6]:[n&H1&+0&D2:5]:[n:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[n&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][n:5][nH:6][cH:7]1.[O-:8][n+:9]1[n:10][c:11]([n:12][c:13]2[cH:14][cH:15][c:16]([cH:17][c:18]21)[Cl:19])Cl>CN(C)C=O.[NaH]>[CH3:1][O:2][c:3]1[cH:4][n:5][n:6]([cH:7]1)-[c:11]1[n:12][c:13]2[cH:14][cH:15][c:16]([cH:17][c:18]2[n+:9]([n:10]1)[O-:8])[Cl:19]|US20060148858A1_0935
3.3.3|[C&H1&+0&D1:5]#[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H0&+0&D2:5](#[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH:1]#[C:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:11][C:12]([CH3:13])([CH3:14])[C:15](=[O:16])Cl>Cc1ccccc1.CCN(CC)CC.Br[Cu]>[CH3:11][C:12]([CH3:13])([CH3:14])[C:15](=[O:16])[C:1]#[C:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|US20200131129A1_0619
9.7.43|[N&H2&+0&D1:5]-[N&H2&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|O.[NH2:1][NH2:2].Cl[c:3]1[n:4][n:5][c:6]([s:7]1)-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>CC(C)O>[NH2:1][NH:2][c:3]1[n:4][n:5][c:6]([s:7]1)-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US20190345152A1_0632
1.3.7|[c:6]:[n&H1&+0&D2:5]:[c:4].[n:3]:[c&H0&+0&D3:2](:[o:1])-Cl>>[c:6]:[n&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[o:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:7])[c:8]1[o:9][c:10]([n:11][c:12]1-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19])Cl.[CH3:20][c:21]1[n:22][cH:23][cH:24][nH:25]1>O.CN(C)C=O.[NaH]>[CH3:20][c:21]1[n:22][cH:23][cH:24][n:25]1-[c:10]1[n:11][c:12]([c:8]([o:9]1)[C:6](=[O:7])[C:4](=[O:5])[O:3][CH2:2][CH3:1])-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19]|US07183276B2_1136
3.11.86|[C:6]-[C&H2&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][C:6](=[O:7])[O:8][CH3:9].[O-:10][N+:11](=[O:12])[c:13]1[cH:14][c:15]([cH:16][cH:17][c:18]1Br)[Br:19]>[NH4+].[Cl-].CS(C)=O.[NaH]>[CH3:1][O:2][C:3](=[O:4])[CH:5]([C:6](=[O:7])[O:8][CH3:9])[c:18]1[cH:17][cH:16][c:15]([cH:14][c:13]1[N+:11]([O-:10])=[O:12])[Br:19]|US06323369B1
4.2.9|[C&H3&+0&D1:4]-[S&+](-C)-C.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H2&+0&D2:4]1-[O&H0&+0&D2:3]-[C&H1&+0&D3:2]-1-[c:1]|[I-].C[S+](C)[CH3:1].[O:2]=[CH:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[Cl:10]>O.CS(C)=O.C1CCOC1.[NaH]>[Cl:10][c:8]1[cH:7][cH:6][cH:5][c:4]([cH:9]1)[CH:3]1[CH2:1][O:2]1|US08835426B2_0214
4.1.42|[C&H1&+0&D1:5]#[C&H0&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[c&H1&+0&D2:5]1:[n&H1&+0&D2:1]:[c:2]:[c:3]:[c&H1&+0&D2:4]:1|[CH:1]#[C:2][c:3]1[n:4][c:5]([c:6]([n:7][c:8]1[NH2:9])-[c:10]1[cH:11][cH:12][cH:13][o:14]1)-[c:15]1[cH:16][cH:17][n:18][cH:19][cH:20]1>CN1CCCC1=O.CC(C)(C)[O-].[K+]>[cH:13]1[cH:12][cH:11][c:10]([o:14]1)-[c:6]1[n:7][c:8]2[nH:9][cH:1][cH:2][c:3]2[n:4][c:5]1-[c:15]1[cH:16][cH:17][n:18][cH:19][cH:20]1|US20200085822A1_1030
2.1.1|[N&H2&+0&D1:5]-[S:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H1&+0&D2:5](-[S:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[C:11](=[O:12])Cl.[NH2:13][S:14](=[O:15])(=[O:16])[CH:17]=[CH:18][c:19]1[cH:20][cH:21][c:22]([c:23]([cH:24]1)[Cl:25])[Cl:26]>O=P(Cl)(Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[C:11](=[O:12])[NH:13][S:14](=[O:15])(=[O:16])[CH:17]=[CH:18][c:19]1[cH:20][cH:21][c:22]([c:23]([cH:24]1)[Cl:25])[Cl:26]|US08754068B2_0274
9.7.26|[N&H2&+0&D1:5]-[N&H2&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][CH2:8][n:9]1[cH:10][cH:11][c:12]2[c:13]1[n:14][cH:15][cH:16][c:17]2Br.[NH2:18][NH2:19]>CO>[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][CH2:8][n:9]1[cH:10][cH:11][c:12]2[c:13]1[n:14][cH:15][cH:16][c:17]2[NH:19][NH2:18]|US20190381019A1_0837
1.3.6|[C:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1.Br[c:12]1[cH:13][cH:14][cH:15][cH:16][n:17]1>O.O.Cc1ccccc1.[NaH]>[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([c:12]1[cH:13][cH:14][cH:15][cH:16][n:17]1)[c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1|EP3632915A1_1101
1.3.6|[C:6]-[N&H1&+0&D2:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[N&H0&+0&D3:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][S:7](=[O:8])(=[O:9])[NH:10][CH2:11][CH2:12][CH2:13][c:14]1[c:15]([cH:16][n:17][cH:18][c:19]1[Br:20])Br>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccccc1.O=C(O[K])O[K]>[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][S:7](=[O:8])(=[O:9])[N:10]1[CH2:11][CH2:12][CH2:13][c:14]2[c:15]1[cH:16][n:17][cH:18][c:19]2[Br:20]|EP3138840B1_0562
1.3.7|[c:6]:[n&H1&+0&D2:5]:[c:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[c:6]:[n&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[NH2:1][c:2]1[n:3][c:4]([n:5][c:6]2[cH:7][cH:8][c:9]3[nH:10][cH:11][cH:12][c:13]3[c:14]12)[NH2:15].Cl[c:16]1[n:17][c:18]2[cH:19][cH:20][cH:21][cH:22][c:23]2[s:24]1>CN(C)C=O.[NaH]>[NH2:15][c:4]1[n:5][c:6]2[cH:7][cH:8][c:9]3[c:13]([cH:12][cH:11][n:10]3-[c:16]3[n:17][c:18]4[cH:19][cH:20][cH:21][cH:22][c:23]4[s:24]3)[c:14]2[c:2]([n:3]1)[NH2:1]|US06605629B1
1.3.7|[N&H2&+0&D1:5]-[O&H1&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:5](-[O&H1&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][n:2]1[n:3][c:4]([c:5]2[c:6]1[n:7][cH:8][n:9][c:10]2Cl)-[c:11]1[cH:12][cH:13][c:14]([o:15]1)[N+:16]([O-:17])=[O:18].[NH2:19][OH:20]>CO.CCO>[CH3:1][n:2]1[n:3][c:4]([c:5]2[c:6]1[n:7][cH:8][n:9][c:10]2[NH:19][OH:20])-[c:11]1[cH:12][cH:13][c:14]([o:15]1)[N+:16]([O-:17])=[O:18]|US20190389812A1_0683
1.6.2|[C:6]-[C&H1&+0&D3:5](-[C:4])-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Br)[CH2:7][CH2:8][CH2:9][CH3:10].[Br:11][c:12]1[n:13][nH:14][c:15]([c:16]1[Br:17])[Br:18]>CC(C)=O.O=C(O[K])O[K]>[CH3:10][CH2:9][CH2:8][CH2:7][CH:6]([C:4](=[O:5])[O:3][CH2:2][CH3:1])[n:14]1[n:13][c:12]([c:16]([c:15]1[Br:18])[Br:17])[Br:11]|EP3313844B1_0134
2.1.1|[N&H2&+0&D1:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Br>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH2:2][O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[NH2:10].[CH3:11][c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[C:18](=[O:19])Br>CC(C)=O.O=C(O)O[Na]>[CH3:11][c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[C:18](=[O:19])[NH:10][c:9]1[cH:8][cH:7][cH:6][cH:5][c:4]1[O:3][CH2:2][CH3:1]|US08748426B2_1929
1.3.7|[c:6]:[n&H1&+0&D2:5]:[n:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[c:6]:[n&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][c:2]1[cH:3][cH:4][nH:5][n:6]1.[O-:7][N+:8](=[O:9])[c:10]1[s:11][c:12]([n:13][c:14]1[Cl:15])Cl>O.O.CN1CCCC1=O>[CH3:1][c:2]1[cH:3][cH:4][n:5]([n:6]1)-[c:12]1[n:13][c:14]([c:10]([s:11]1)[N+:8]([O-:7])=[O:9])[Cl:15]|US20050277665A1_0326
2.1.41|[N&H2&+0&D1:5]-[O:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H1&+0&D2:5](-[O:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[NH2:9][O:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][O:16]1>CCN(CC)CC.CCOC(C)=O.ClCCl>[O:1]=[C:2]([NH:9][O:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][O:16]1)[c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1|US20200165243A1_0339
4.2.9|[C&H3&+0&D1:4]-[S&+](-C)-C.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H2&+0&D2:4]1-[O&H0&+0&D2:1]-[C&H1&+0&D3:2]-1-[C:3]|[CH2:1]=[C:2]1[CH2:3][CH2:4][CH2:5][C@@H:6]2[CH2:7][CH2:8][C@H:9]3[C@@H:10]4[C@H:11]([C:12]56[O:13][CH2:14][CH2:15][O:16][C:17]5([O:18][CH2:19][CH2:20][O:21]6)[C@:22]4([CH2:23][CH2:24][C@@H:25]3[C@@:26]12[CH3:27])[CH3:28])[CH:29]=[O:30].C[S+](C)[CH3:31].[I-]>CN(C)C=O.CC(C)(C)[O-].ClCCl.O.O.[K+]>[CH2:1]=[C:2]1[CH2:3][CH2:4][CH2:5][C@@H:6]2[CH2:7][CH2:8][C@H:9]3[C@@H:10]4[C@H:11]([C:12]56[O:21][CH2:20][CH2:19][O:18][C:17]5([O:16][CH2:15][CH2:14][O:13]6)[C@:22]4([CH2:23][CH2:24][C@@H:25]3[C@@:26]12[CH3:27])[CH3:28])[CH:29]1[CH2:31][O:30]1|US09840513B2_1231
9.7.43|[N&H2&+0&D1:5]-[N&H2&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH2:1][NH2:2].[O:3]=[C:4]([OH:5])[c:6]1[n:7][c:8]([c:9]([c:10]([c:11]1[Cl:12])Cl)[Cl:13])[Cl:14]>O.Cl.O[Na]>[NH2:1][NH:2][c:10]1[c:11]([c:6]([n:7][c:8]([c:9]1[Cl:13])[Cl:14])[C:4](=[O:3])[OH:5])[Cl:12]|US07511145B2_1041
1.7.9|[O&H1&+0&D1:5]-[c:4].[O:3]-[C&H0&+0&D3:2](=[S&H0&D1:1])-Cl>>[O&H0&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](-[O:3])=[S&H0&D1:1]|[CH3:1][O:2][C:3](=[S:4])Cl.[CH3:5][c:6]1[cH:7][c:8]([c:9]([c:10]([cH:11]1)[Cl:12])-[c:13]1[c:14]([o:15][c:16]([cH:17][c:18]1[OH:19])-[c:20]1[cH:21][cH:22][cH:23][n:24][cH:25]1)=[O:26])[Cl:27]>>[CH3:1][O:2][C:3](=[S:4])[O:19][c:18]1[cH:17][c:16]([o:15][c:14]([c:13]1-[c:9]1[c:10]([cH:11][c:6]([cH:7][c:8]1[Cl:27])[CH3:5])[Cl:12])=[O:26])-[c:20]1[cH:25][n:24][cH:23][cH:22][cH:21]1|
2.1.11|[N&H2&+0&D1:5]-[N:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[N&H1&+0&D2:5](-[N:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH2:2][CH2:3][CH2:4][O:5][C:6](=[O:7])Cl.[NH2:8][NH:9][c:10]1[n:11][nH:12][c:13]2[cH:14][c:15]([cH:16][cH:17][c:18]21)[Cl:19]>O.c1ccncc1>[CH3:1][CH2:2][CH2:3][CH2:4][O:5][C:6](=[O:7])[NH:8][NH:9][c:10]1[n:11][nH:12][c:13]2[cH:14][c:15]([cH:16][cH:17][c:18]21)[Cl:19]|EP0534344A1_0043
3.11.91|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H1&+0&D3:3](-[C:2])-[S:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[S:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[O:7][CH2:8][C:9]([CH:10]([S:11][c:12]2[cH:13]1)[C:14](=[O:15])[O:16][CH3:17])=[O:18].[Cl:19][CH2:20][CH2:21][CH2:22]Br>CCCC[N+](CCCC)(CCCC)CCCC.O=C(O[K])O[K].CC#N.I[K].[I-]>[CH3:17][O:16][C:14](=[O:15])[C:10]1([S:11][c:12]2[cH:13][c:3]([cH:4][cH:5][c:6]2[O:7][CH2:8][C:9]1=[O:18])[O:2][CH3:1])[CH2:22][CH2:21][CH2:20][Cl:19]|EP1368014B1_0029
1.6.4|[C:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][CH:3]([O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[C:11]([CH3:12])([CH3:13])[CH2:14][CH3:15])[C:16]([CH3:17])([CH3:18])[CH2:19][CH3:20])[C:21](=[O:22])[NH:23][c:24]1[cH:25][cH:26][c:27]([c:28]([cH:29]1)[NH:30][C:31](=[O:32])[CH:33](Cl)[C:34](=[O:35])[C:36]([CH3:37])([CH3:38])[CH3:39])[Cl:40].[CH3:41][CH2:42][C:43]([Br:44])=[C:45]1[NH:46][C:47]([NH:48][C:49]1=[O:50])=[O:51]>CN(C)C=O.CO.O[K].O>[CH3:41][CH2:42][C:43]([Br:44])=[C:45]1[NH:46][C:47]([N:48]([C:49]1=[O:50])[CH:33]([C:31](=[O:32])[NH:30][c:28]1[cH:29][c:24]([cH:25][cH:26][c:27]1[Cl:40])[NH:23][C:21](=[O:22])[CH:3]([CH2:2][CH3:1])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[C:11]([CH3:12])([CH3:13])[CH2:14][CH3:15])[C:16]([CH3:17])([CH3:18])[CH2:19][CH3:20])[C:34](=[O:35])[C:36]([CH3:37])([CH3:38])[CH3:39])=[O:51]|EP2313403B1_0125
3.11.52|[C:6]-[C&H1&+0&D3:5](-[C:4])-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH:2]([CH3:3])[N:4]([CH2:5][CH2:6][CH:7]([C:8]#[N:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[CH:16]([CH3:17])[CH3:18].Cl[CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][n:25]1.Cl>ClCc1ccccn1.Cc1ccccc1.O=C(O[K])O[K].O.[KH]>[CH3:1][CH:2]([CH3:3])[N:4]([CH2:5][CH2:6][C:7]([C:8]#[N:9])([CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][n:25]1)[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[CH:16]([CH3:17])[CH3:18]|EP3680240A1_0061
3.11.86|[C:6]-[C&H2&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[Cl:9])Br.[O:10]=[C:11]1[CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]2[CH2:20]1>Cl.CC(=O)O[Pd]OC(C)=O.CC(=O)OCC.CN(C)C=O.[NaH]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[Cl:9])[CH:20]1[C:11]([CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21)=[O:10]|EP1736467A1_0520
2.5.7|[c:6]:[n&H1&+0&D2:5]:[n:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-S-C>>[c:6]:[n&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][n:8][nH:9][cH:10]1.CS[c:11]1[n:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[c:19]([nH:20]1)=[O:21]>O.Cl.CN(C)C=O>[CH3:1][O:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][n:8][n:9]([cH:10]1)-[c:11]1[n:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[c:19]([nH:20]1)=[O:21]|US20190218200A1_2597
2.1.15|[N&H2&+0&D1:5]-[N:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O-C>>[N&H1&+0&D2:5](-[N:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][O:2][C:3](=[O:4])OC.[CH3:5][CH:6]([CH3:7])[C:8](=[O:9])[NH:10][NH2:11]>>[CH3:1][O:2][C:3](=[O:4])[NH:11][NH:10][C:8](=[O:9])[CH:6]([CH3:5])[CH3:7]|US20190330142A1_0192
2.6.9|[C:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-O.[C:2]-[O&H1&+0&D1:1]>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C@@H:2]([NH:3][C:4](=[O:5])[O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[C:14](=[O:15])[OH:16].O[C:17]12[CH2:18][CH:19]3[CH2:20][CH:21]([CH2:22][CH:23]([CH2:24]3)[CH2:25]1)[CH2:26]2>C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1ccncc1.CCOC(C)=O.C1CCOC1.CC(=O)O>[CH3:1][C@@H:2]([NH:3][C:4](=[O:5])[O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[C:14](=[O:15])[O:16][C:17]12[CH2:26][CH:21]3[CH2:20][CH:19]([CH2:24][CH:23]([CH2:22]3)[CH2:25]1)[CH2:18]2|US20100130712A1_0454
9.5.4|[Br&H0&D1:5]-[C&H1&+0&D3:4](-[C:3])-[C&H1&+0&D3:2](-[c:1])-O>>[Br&H0&D1:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[c:1]|O[CH:1]1[c:2]2[cH:3][c:4]([cH:5][cH:6][c:7]2[CH2:8][CH:9]1[Br:10])-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>CCOCC.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[Br:10][C:9]1=[CH:1][c:2]2[cH:3][c:4]([cH:5][cH:6][c:7]2[CH2:8]1)-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US06528646B2
1.2.9|[C:6]-[C&H1&+0&D3:5](-[C:4])-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C@@&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]([CH3:10])[CH:11](O)[CH:12]([CH3:13])[CH3:14].[O:15]=[C:16]1[NH:17][C:18]([c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]12)=[O:25]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CC(C)OC(=O)/N=N/C(=O)OC(C)C.C1CCOC1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]([CH3:10])[C@@H:11]([CH:12]([CH3:14])[CH3:13])[N:17]1[C:18]([c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[C:16]1=[O:15])=[O:25]|US10106515B2_0365
10.4.3|[O&H2&+0&D0:5].[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[O&H1&+0&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH2:1]=[C:2]1[CH2:3][CH2:4][N:5]([c:6]2[c:7]([cH:8][cH:9][cH:10][c:11]12)[CH2:12][O:13][Si:14]([CH3:15])([CH3:16])[C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:21][CH3:22].[OH2:23]>C1CCOC1.OO.O[Na]>[CH3:18][C:17]([CH3:19])([CH3:20])[Si:14]([CH3:15])([CH3:16])[O:13][CH2:12][c:7]1[cH:8][cH:9][cH:10][c:11]2[c:6]1[N:5]([CH2:4][CH2:3][CH:2]2[CH2:1][OH:23])[CH2:21][CH3:22]|EP3226688B1_0361
7.6.1|[C:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:3](-[C:2])-[N:1]>>[C:6]-[C@&H1&+0&D3:5](-[c:4])-[C@&H1&+0&D3:3](-[C:2])-[N:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[C:8]3[CH2:9][C:10]([NH:11][C:12]=3[CH2:13][CH2:14][c:15]12)=[O:16]>CC[SiH](CC)CC.O=C(O)C(F)(F)F.ClCCl.O[Na].O>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[c:15]1[CH2:14][CH2:13][C@@H:12]1[NH:11][C:10]([CH2:9][C@H:8]21)=[O:16]|US20190290632A1_0500
2.1.2|[C:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[O&-]>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH2:6][NH2:7].[O-][C:8](=[O:9])[N:10]1[C:11]([CH2:12][c:13]2[cH:14][c:15]([cH:16][cH:17][c:18]21)[Cl:19])=[O:20]>>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:9])[N:10]1[C:11]([CH2:12][c:13]2[cH:14][c:15]([cH:16][cH:17][c:18]21)[Cl:19])=[O:20]|US09029560B2_1009
2.6.2|[C:5]-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[O&-]>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][C:6]1[CH2:7][S:8][CH:9]2[CH:10]([C:11]([N:12]2[C:13]=1[C:14]([O-])=[O:15])=[O:16])[NH2:17].[CH3:18][C:19]([CH3:20])([CH3:21])[C:22](=[O:23])[O:24][c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[CH2:31][OH:32].[Na+]>C(=NC1CCCCC1)=NC1CCCCC1.CN(C)C=O>[CH3:1][C:2](=[O:3])[O:4][CH2:5][C:6]1[CH2:7][S:8][CH:9]2[CH:10]([C:11]([N:12]2[C:13]=1[C:14](=[O:15])[O:32][CH2:31][c:28]1[cH:27][cH:26][c:25]([cH:30][cH:29]1)[O:24][C:22](=[O:23])[C:19]([CH3:18])([CH3:20])[CH3:21])=[O:16])[NH2:17]|EP2588461B1_0037
2.6.2|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O-][C:1](=[O:2])[c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[C:9](=[O:10])[OH:11])[F:12].[K+]>[O-][Mn](=O)(=O)=O.[K+]>[O:10]=[C:9]1[O:11][C:1]([c:3]2[cH:4][cH:5][c:6]([cH:7][c:8]12)[F:12])=[O:2]|EP1443041A1_0099
3.11.14|[C:5]-[C&H1&+0&D2:4]=[C:3].[O&H0&D1:2]=[C&H1&+0&D2:1]-N(-C)-C>>[C:5]-[C&H0&+0&D3:4](=[C:3])-[C&H1&+0&D2:1]=[O&H0&D1:2]|CN(C)[CH:1]=[O:2].[CH3:3][N:4]([CH3:5])[CH:6]=[CH:7][C:8]#[N:9]>O=P(Cl)(Cl)Cl.O[Na].ClCCCl>[CH3:3][N:4]([CH3:5])[CH:6]=[C:7]([C:8]#[N:9])[CH:1]=[O:2]|US20150148349A1_0629
3.9.10|[C:5]=[C&H1&+0&D2:4]-I.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C:5]=[C&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH2:1]=[C:2]1[CH2:3][C@@H:4]([O:5][C@H:6]1[CH2:7][CH2:8][C@H:9]1[CH2:10][C@H:11]([C:12]([C@H:13]([O:14]1)[CH2:15][C@@H:16]1[O:17][C@@H:18]([C@@H:19]([C@H:20]1[CH2:21][C:22](=[O:23])[CH2:24][C@H:25]1[CH2:26][CH2:27][C@@H:28]2[O:29][C@H:30]([C@H:31]([C@H:32]([C@H:33]2[O:34]1)[O:35][Si:36]([CH3:37])([CH3:38])[C:39]([CH3:40])([CH3:41])[CH3:42])[O:43][Si:44]([CH3:45])([CH3:46])[C:47]([CH3:48])([CH3:49])[CH3:50])[C@H:51]([CH:52]=[CH:53]I)[O:54][Si:55]([CH3:56])([CH3:57])[C:58]([CH3:59])([CH3:60])[CH3:61])[O:62][CH3:63])[CH2:64][C@@H:65]([CH2:66][O:67][Si:68]([CH3:69])([CH3:70])[C:71]([CH3:72])([CH3:73])[CH3:74])[O:75][Si:76]([CH3:77])([CH3:78])[C:79]([CH3:80])([CH3:81])[CH3:82])=[CH2:83])[CH3:84])[CH2:85][CH2:86][CH:87]=[O:88]>Cl[Cr]Cl.Cl[Ni]Cl>[CH2:83]=[C:12]1[C@@H:11]([CH2:10][C@@H:9]2[CH2:8][CH2:7][C@@H:6]3[O:5][C@H:4]([CH2:3][C:2]3=[CH2:1])[CH2:85][CH2:86][CH:87]([CH:53]=[CH:52][C@@H:51]([C@@H:30]3[O:29][C@H:28]4[CH2:27][CH2:26][C@H:25]([CH2:24][C:22]([CH2:21][C@@H:20]5[C@H:19]([C@H:18]([O:17][C@H:16]5[CH2:15][C@H:13]1[O:14]2)[CH2:64][C@@H:65]([CH2:66][O:67][Si:68]([CH3:69])([CH3:70])[C:71]([CH3:72])([CH3:73])[CH3:74])[O:75][Si:76]([CH3:77])([CH3:78])[C:79]([CH3:80])([CH3:81])[CH3:82])[O:62][CH3:63])=[O:23])[O:34][C@@H:33]4[C@@H:32]([C@@H:31]3[O:43][Si:44]([CH3:45])([CH3:46])[C:47]([CH3:48])([CH3:49])[CH3:50])[O:35][Si:36]([CH3:37])([CH3:38])[C:39]([CH3:40])([CH3:41])[CH3:42])[O:54][Si:55]([CH3:56])([CH3:57])[C:58]([CH3:59])([CH3:60])[CH3:61])[OH:88])[CH3:84]|US20190161495A1_0692
1.1.3|[C&H3&+0&D1:5]-I.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[C&H3&+0&D1:5]-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1]I.[O:2]=[C:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[S:10]([c:11]2[cH:12][c:13]([cH:14][cH:15][c:16]12)-[c:17]1[n:18][n:19][n:20][nH:21]1)(=[O:22])=[O:23]>[Na+].CC[O-].CCO>[CH3:1][n:20]1[n:19][n:18][c:17]([n:21]1)-[c:13]1[cH:14][cH:15][c:16]2[C:3]([c:4]3[cH:5][cH:6][cH:7][cH:8][c:9]3[S:10]([c:11]2[cH:12]1)(=[O:22])=[O:23])=[O:2]|US20190270754A1_0631
3.11.1|[C&H2&+0&D1:5]=[O&H0&+0&D1:4].[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H2&+0&D2:5](-[O&H1&+0&D1:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH2:1]=[O:2].[O:3]=[C:4]1[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1>>[O:3]=[C:4]1[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]1[CH2:1][OH:2]|US08569341B2_2978
3.11.14|[O&H0&D1:5]=[C&H1&+0&D2:4]-N(-C)-C.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[O&H0&D1:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][O:2][CH:3]([O:4][CH3:5])[c:6]1[cH:7][cH:8][s:9][cH:10]1.CN(C)[CH:11]=[O:12]>O.CCOCC.CCCC[Li]>[CH3:1][O:2][CH:3]([O:4][CH3:5])[c:6]1[cH:7][cH:8][s:9][c:10]1[CH:11]=[O:12]|US08148373B2_0702
10.4.3|[O&H2&+0&D0:5].[C&H2&+0&D1:4]=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[O&H1&+0&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]|[OH2:1].[CH2:2]=[C:3]1[CH2:4][CH2:5][CH2:6][CH:7]([CH2:8]1)[c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[OH:15])[C:16]([CH3:17])([CH3:18])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]>O.O.[Na+].CC([O-])=O.OO.C1CCOC1>[CH3:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][C:16]([CH3:17])([CH3:18])[c:12]1[cH:11][cH:10][c:9]([c:14]([cH:13]1)[OH:15])[CH:7]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:8]1)[CH2:2][OH:1]|EP3750909A1_0236
3.11.14|[O&H0&D1:5]=[C&H1&+0&D2:4]-N(-C)-C.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[O&H0&D1:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][n:2]1[cH:3][n:4][cH:5][c:6]1-[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.CN(C)[CH:13]=[O:14]>CCCC[Li]>[CH3:1][n:2]1[c:3]([n:4][cH:5][c:6]1-[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[CH:13]=[O:14]|EP3511002B1_0245
3.11.38|[C&H1&+0&D1:5]#[C:4].[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H0&+0&D2:5](#[C:4])-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH:1]#[C:2][CH2:3][CH2:4][CH3:5].[O:6]=[CH:7][CH2:8][CH2:9][Cl:10]>[NH4+].[Cl-].CCCCCC.CCCC[Li]>[CH3:5][CH2:4][CH2:3][C:2]#[C:1][CH:7]([OH:6])[CH2:8][CH2:9][Cl:10]|US06784167B2
1.3.3|[c:6]:[c&H0&+0&D3:5](:[se:4])-I.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:6]:[c&H0&+0&D3:5](:[se:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[NH:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[c:13]1[cH:14][cH:15][cH:16][cH:17]2.I[c:18]1[cH:19][cH:20][cH:21][se:22]1>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.Cc1ccccc1.CC(C)(C)[O-].[Na+].[Pd]>[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[N:7]([c:18]1[cH:19][cH:20][cH:21][se:22]1)[c:8]1[cH:9][cH:10][cH:11][c:12]2[c:13]1[cH:14][cH:15][cH:16][cH:17]2|US20200308167A1_0419
1.2.5|[C:6]-[C&H0&+0&D3:5](-[C:4])=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C@@&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([C:4](=[O:5])[NH:6][C@:7]1([CH2:8][C@@H:9]([C:10]([CH2:11][CH2:12]1)=O)[F:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][c:22]([cH:23][c:24]([cH:25]1)[C:26]([F:27])([F:28])[F:29])[C:30]([F:31])([F:32])[F:33].[CH2:34]1[CH2:35][C:36]2([CH2:37][O:38]1)[CH2:39][CH2:40][NH:41][CH2:42][CH2:43]2.Cl>CC(=O)O[BH-](OC(C)=O)OC(C)=O.CCN(CC)CC.ClCCCl.O[Na].[Na+]>[CH3:1][C:2]([CH3:3])([C:4](=[O:5])[NH:6][C@@:7]1([CH2:12][CH2:11][C@H:10]([C@H:9]([CH2:8]1)[F:13])[N:41]1[CH2:40][CH2:39][C:36]2([CH2:35][CH2:34][O:38][CH2:37]2)[CH2:43][CH2:42]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][c:22]([cH:23][c:24]([cH:25]1)[C:26]([F:27])([F:28])[F:29])[C:30]([F:31])([F:32])[F:33]|US20200277259A1_0798
3.11.1|[C&H3&+0&D1:5]-[C:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H2&+0&D2:5](-[C:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][C:2](=[O:3])[CH:4]([O:5][Si:6]([CH3:7])([CH3:8])[C:9]([CH3:10])([CH3:11])[CH3:12])[CH:13]([CH3:14])[O:15][Si:16]([CH3:17])([CH3:18])[C:19]([CH3:20])([CH3:21])[CH3:22].[O:23]=[CH:24][c:25]1[cH:26][o:27][cH:28][n:29]1>CC(C)[N-]C(C)C.C1CCOC1.Cl.[Li].[Li+]>[CH3:10][C:9]([CH3:11])([CH3:12])[Si:6]([CH3:7])([CH3:8])[O:5][CH:4]([C:2](=[O:3])[CH2:1][CH:24]([OH:23])[c:25]1[cH:26][o:27][cH:28][n:29]1)[CH:13]([CH3:14])[O:15][Si:16]([CH3:17])([CH3:18])[C:19]([CH3:20])([CH3:21])[CH3:22]|US09714238B2_0135
1.3.3|[c:6]:[c&H0&+0&D3:5](:[te:4])-I.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[c:6]:[c&H0&+0&D3:5](:[te:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[cH:1]1[cH:2][cH:3][c:4]2[Se:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[NH:12][c:13]2[cH:14]1.I[c:15]1[cH:16][cH:17][cH:18][te:19]1>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.Cc1ccccc1.CCCCCC.CC(C)(C)[O-].[Na+].[Pd]>[cH:1]1[cH:2][cH:3][c:4]2[Se:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[N:12]([c:13]2[cH:14]1)[c:15]1[cH:16][cH:17][cH:18][te:19]1|EP3473622B1_0191
3.11.14|[O&H0&D1:5]=[C&H1&+0&D2:4]-N(-C)-C.[c:3]:[c&H1&+0&D2:2]:[o:1]>>[O&H0&D1:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][o:16]1.CN(C)[CH:17]=[O:18]>O.O=C(O[Na])O[Na].O=P(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([o:16]1)[CH:17]=[O:18]|US09683003B2_0621
10.4.15|[C:5]-[N&H1&+0&D2:4]-[c:3].[O&H0&D1:2]=[N&H0&+0&D2:1]-O-[#11]>>[C:5]-[N&H0&+0&D3:4](-[c:3])-[N&H0&+0&D2:1]=[O&H0&D1:2]|[O:1]=[N:2]O[Na].[Cl:3][c:4]1[cH:5][cH:6][c:7]2[NH:8][CH2:9][CH2:10][c:11]2[cH:12]1>O.Cl>[O:1]=[N:2][N:8]1[CH2:9][CH2:10][c:11]2[cH:12][c:4]([cH:5][cH:6][c:7]21)[Cl:3]|US20200347043A1_1080
2.1.3|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&-].[N&H2&+0&D1:2]-[N:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N:1])=[O&H0&D1:3]|[O-][C:1](=[O:2])[CH:3]1[CH2:4][CH2:5][C:6]2([CH2:7][CH2:8]1)[O:9][CH2:10][CH2:11][O:12]2.[CH3:13][CH2:14][O:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[NH:22][NH2:23].[Na+].Cl>CC(C)COC(=O)Cl.CCN(CC)CC.C1CCOC1.O>[CH3:13][CH2:14][O:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[NH:22][NH:23][C:1](=[O:2])[CH:3]1[CH2:4][CH2:5][C:6]2([CH2:7][CH2:8]1)[O:9][CH2:10][CH2:11][O:12]2|US20180282331A1_0574
7.6.1|[C:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[C:6]-[C@@&H1&+0&D3:5](-[c:4])-[C&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][O:2][C:3](=[O:4])[C:5](=[C:6]1[CH2:7][N:8]([CH2:9]1)[C@@H:10]([c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17])[c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[C:24]#[N:25])[c:26]1[cH:27][c:28]([cH:29][c:30]([cH:31]1)[F:32])[Br:33]>[Na+].CO.C1CCOC1.[BH4-]>[CH3:1][O:2][C:3](=[O:4])[C@H:5]([c:26]1[cH:27][c:28]([cH:29][c:30]([cH:31]1)[F:32])[Br:33])[CH:6]1[CH2:7][N:8]([CH2:9]1)[C@@H:10]([c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17])[c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[C:24]#[N:25]|US20080275085A1_0877
2.1.17|[N&H2&+0&D1:5]-[S:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[N&H1&+0&D2:5](-[S:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|CO[C:1](=[O:2])[NH:3][c:4]1[n:5][c:6]([n:7][c:8]([n:9]1)[O:10][CH3:11])[O:12][CH3:13].[NH2:14][S:15](=[O:16])(=[O:17])[c:18]1[c:19]([cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][n:26][c:27]21)[Cl:28]>Cc1ccccc1.C[Al](C)C.ClCCl>[CH3:11][O:10][c:8]1[n:7][c:6]([n:5][c:4]([n:9]1)[NH:3][C:1](=[O:2])[NH:14][S:15](=[O:16])(=[O:17])[c:18]1[c:19]([cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][n:26][c:27]21)[Cl:28])[O:12][CH3:13]|US04521241A
2.1.2|[C:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[O&-]>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[Na+].[CH3:1][O:2][N:3]=[C:4]([C:5]([O-])=[O:6])[c:7]1[cH:8][cH:9][cH:10][s:11]1.[NH2:12][C:13](=[O:14])[O:15][CH2:16][C:17]1[CH2:18][S:19][C@@H:20]2[C@@H:21]([C:22]([N:23]2[C:24]=1[C:25](=[O:26])[OH:27])=[O:28])[NH2:29]>O=C1CCN1.C1COCCO1>[CH3:1][O:2][N:3]=[C:4]([C:5](=[O:6])[NH:29][C@@H:21]1[C:22]([N:23]2[C:24](=[C:17]([CH2:18][S:19][C@H:20]12)[CH2:16][O:15][C:13]([NH2:12])=[O:14])[C:25](=[O:26])[OH:27])=[O:28])[c:7]1[cH:8][cH:9][cH:10][s:11]1|US05637613A
2.5.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[N:3]=[C&H0&+0&D3:2](-[N:1])-S-C>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[N:3])-[N:1]|[CH3:1][N:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1.CS[C:8]1=[N:9][c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]2[S:16]([NH:17]1)(=[O:18])=[O:19])[Cl:20]>>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[C:8]1=[N:9][c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]2[S:16]([NH:17]1)(=[O:18])=[O:19])[Cl:20]|US20190241554A1_2781
3.11.38|[C&H1&+0&D1:5]#[C:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H0&+0&D2:5](#[C:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH:1]#[C:2][CH2:3][N:4]([CH2:5][CH3:6])[CH2:7][CH3:8].[O:9]=[CH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O.CCBr.CCOCC.CCOC(C)=O.CC[Mg]Br.C1CCOC1.[Mg]>[CH3:8][CH2:7][N:4]([CH2:5][CH3:6])[CH2:3][C:2]#[C:1][CH:10]([OH:9])[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US20110251390A1_0111
10.4.17|[O:6]-[B&H0&+0&D3:5](-[O:4])-O-C.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[O:6]-[B&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][n:5]([n:6]1)[CH:7]1[CH2:8][CH2:9][CH2:10][CH2:11][O:12]1.[CH3:13][C:14]1([O:15][B:16]([O:17][C:18]1([CH3:19])[CH3:20])OC)[CH3:21]>CCCCCC.CCCC[Li].C1CCOC1>[CH3:1][c:2]1[cH:3][c:4]([n:5]([n:6]1)[CH:7]1[CH2:8][CH2:9][CH2:10][CH2:11][O:12]1)[B:16]1[O:15][C:14]([C:18]([O:17]1)([CH3:19])[CH3:20])([CH3:13])[CH3:21]|US20200308172A1_0595
3.11.14|[O&H0&D1:5]=[C&H1&+0&D2:4]-N(-C)-C.[n:3]:[c&H1&+0&D2:2]:[s:1]>>[O&H0&D1:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|CN(C)[CH:1]=[O:2].[cH:3]1[n:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[s:11]1>O.CCCC[Li].C1CCOC1>[O:2]=[CH:1][c:3]1[n:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[s:11]1|EP3604315A1_0073
2.1.2|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&-].[N&H2&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[NH2:1][c:2]1[n:3][cH:4][cH:5][s:6]1.[O-][C:7](=[O:8])[CH:9]1[CH2:10][CH2:11][S:12]([c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[C:19]1=[O:20])(=[O:21])=[O:22]>>[O:21]=[S:12]1([CH2:11][CH2:10][CH:9]([C:19]([c:18]2[cH:17][cH:16][cH:15][cH:14][c:13]21)=[O:20])[C:7](=[O:8])[NH:1][c:2]1[n:3][cH:4][cH:5][s:6]1)=[O:22]|EP3543232A1_0223
3.11.17|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[c:2]-[C&H2&+0&D2:1]-Br>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[C:2](Cl)[CH:3]1[CH2:4][CH2:5][CH2:6]1.[F:7][c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[CH2:14]Br>O.CCCCCC.Cc1ccccc1.CCOCC.C1CCOC1.[Mg]>[O:1]=[C:2]([CH2:14][c:13]1[cH:12][cH:11][cH:10][cH:9][c:8]1[F:7])[CH:3]1[CH2:4][CH2:5][CH2:6]1|US20070027199A1_0277
2.6.2|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&-].[O&H1&+0&D1:2]-[c:1]>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][n:2]1[c:3]([cH:4][c:5]([n:6]([c:7]1=[O:8])-[c:9]1[cH:10][c:11]([c:12]([cH:13][c:14]1[F:15])[Cl:16])[OH:17])=[O:18])[C:19]([F:20])([F:21])[F:22].[O-][C:23](=[O:24])[CH2:25][CH2:26][C:27](=[O:28])[O:29][CH2:30][CH2:31][Cl:32]>C(=NC1CCCCC1)=NC1CCCCC1.CN(C)c1ccncc1.ClCCl>[CH3:1][n:2]1[c:7]([n:6]([c:5]([cH:4][c:3]1[C:19]([F:20])([F:21])[F:22])=[O:18])-[c:9]1[cH:10][c:11]([c:12]([cH:13][c:14]1[F:15])[Cl:16])[O:17][C:23](=[O:24])[CH2:25][CH2:26][C:27](=[O:28])[O:29][CH2:30][CH2:31][Cl:32])=[O:8]|US20160214948A1_0096
3.11.14|[O&H0&D1:5]=[C&H1&+0&D2:4]-N(-C)-C.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&D1:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][n:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[cH:9][c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.CN(C)[CH:17]=[O:18]>O.[Na+].CC([O-])=O.O=P(Cl)(Cl)Cl>[CH3:1][n:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[c:9]([c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[CH:17]=[O:18]|US08148373B2_0973
3.11.14|[O&H0&D1:5]=[C&H1&+0&D2:4]-N(-C)-C.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[O&H0&D1:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][s:8][c:9]2[cH:10][c:11]([cH:12][n:13]12)-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.CN(C)[CH:20]=[O:21]>CCN(CC)CC.O=P(Cl)(Cl)Cl.O[Na].O>[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][s:8][c:9]2[cH:10][c:11]([c:12]([n:13]12)[CH:20]=[O:21])-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US06395734B1
7.6.1|[C:6]-[C&H0&+0&D3:5](-[N:4])=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[C:6]-[C@@&H1&+0&D3:5](-[N:4])-[C&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][O:2][C:3](=[O:4])[C:5](/[NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)=[C:17]1/[CH2:18][CH2:19][N:20]([CH2:21][CH2:22]1)[C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29]>C[C@@H]1CC[C@H]([P+]11CC[P]2([C@@H](CC[C@H]2C)C)[Rh]11C2=CCCC=C1CC2)C.[O-]S(=O)(=O)C(F)(F)F.[H][H]>[CH3:27][C:26]([CH3:28])([CH3:29])[O:25][C:23](=[O:24])[N:20]1[CH2:19][CH2:18][CH:17]([CH2:22][CH2:21]1)[C@@H:5]([NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:3](=[O:4])[O:2][CH3:1]|US20200331968A1_0747
1.7.7|[C:6]-[C&H0&+0&D4:5](-[C:4])(-[c:3])-O.[O&H1&+0&D1:2]-[c:1]>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[O&H0&+0&D2:2]-[c:1])-[c:3]|Cl.[ClH:1].[CH3:2][N:3]([CH3:4])[CH2:5][CH2:6][CH2:7][C:8](O)([CH2:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[OH:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>>[ClH:1].[CH3:2][N:3]([CH3:4])[CH2:5][CH2:6][CH2:7][C:8]1([CH2:9][CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[O:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US08710245B2_0493
2.1.2|[C:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][c:9]2[n:10][cH:11][c:12]([c:13]([c:14]2[CH2:15]1)[OH:16])[C:17]([O-])=[O:18].[CH3:19][CH2:20][CH2:21][NH2:22]>>[CH3:19][CH2:20][CH2:21][NH:22][C:17](=[O:18])[c:12]1[cH:11][n:10][c:9]2[CH2:8][CH2:7][N:6]([CH2:15][c:14]2[c:13]1[OH:16])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US09695118B2_1432
1.1.3|[C&H3&+0&D1:5]-I.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[c:1]>>[C&H3&+0&D1:5]-[n&H0&+0&D3:2](:[c:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1]I.[cH:2]1[cH:3][c:4]([n:5][cH:6][n:7]1)-[c:8]1[n:9][c:10]([nH:11][n:12]1)-[c:13]1[cH:14][cH:15][n:16][cH:17][cH:18]1>C1CCOC1.[NaH]>[CH3:1][n:12]1[n:11][c:10]([n:9][c:8]1-[c:4]1[cH:3][cH:2][n:7][cH:6][n:5]1)-[c:13]1[cH:18][cH:17][n:16][cH:15][cH:14]1|EP3322706B1_1152
10.4.15|[C:5]-[N&H1&+0&D2:4]-[C:3].[O&H0&D1:2]=[N&H0&+0&D2:1]-O-[#11]>>[C:5]-[N&H0&+0&D3:4](-[C:3])-[N&H0&+0&D2:1]=[O&H0&D1:2]|Cl.[ClH:1].[CH3:2][c:3]1[n:4][cH:5][c:6]([c:7]([c:8]1[OH:9])[CH2:10][NH:11][C:12](=[O:13])[NH:14][CH2:15][CH2:16][Cl:17])[CH2:18][OH:19].[O:20]=[N:21]O[Na]>>[ClH:1].[CH3:2][c:3]1[n:4][cH:5][c:6]([c:7]([c:8]1[OH:9])[CH2:10][NH:11][C:12](=[O:13])[N:14]([CH2:15][CH2:16][Cl:17])[N:21]=[O:20])[CH2:18][OH:19]|EP2944638A1_0931
3.11.17|[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3])-Cl.[c:2]-[C&H2&+0&D2:1]-Br>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][CH:3]=[C:4]([C:5](=[O:6])[O:7][CH3:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[CH2:15]Br.[O:16]=[C:17](Cl)[c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[Cl:24]>[C-]#N.[C-]#N.C[Si](C)(C)Cl.Cl[Li].BrCCBr.C1CCOC1.[Cu+2].[Zn]>[CH3:1][O:2][CH:3]=[C:4]([C:5](=[O:6])[O:7][CH3:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[CH2:15][C:17](=[O:16])[c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[Cl:24]|US08450313B2_0765
1.8.10|[S&H1&+0&D1:5]-[c:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[S&H0&+0&D2:5](-[c:4])-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[SH:8].[cH:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[CH:15]1[CH2:16][O:17]1>O.Cl.[OH-].[K+]>[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8][CH2:16][CH:15]([OH:17])[c:12]1[cH:11][cH:10][cH:9][cH:14][cH:13]1|EP0288662A1_0020
8.8.5|[O&H0&D1:4]=[C&H1&+0&D2:3]-[c:2].[O&H0&+0&D2:1](-[#11])-[Cl&+]-[O&-]>>[O&H0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[O:6][c:7]1[cH:8][c:9]2[o:10][cH:11][c:12]([c:13]([c:14]2[cH:15][c:16]1[O:17][C:18](=[O:19])[O:20][CH2:21][CH3:22])=[O:23])[CH:24]=[O:25].O=[Cl][O:26][Na]>O.NS(=O)(=O)O.ClCCl>[CH3:22][CH2:21][O:20][C:18](=[O:19])[O:17][c:16]1[cH:15][c:14]2[c:9]([cH:8][c:7]1[O:6][C:4](=[O:5])[O:3][CH2:2][CH3:1])[o:10][cH:11][c:12]([c:13]2=[O:23])[C:24](=[O:25])[OH:26]|EP3230276B1_0958
3.9.3|[C:5]-[C&H2&+0&D2:4]-Cl.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[O:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.Cl[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][O:35][CH2:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1>Cl.CCI.CCOCC.II.C1CCOC1.[Mg]>[OH:1][CH:2]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][O:35][CH2:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[O:17][CH2:18][c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1|EP1414802B1_0218
1.6.4|[C:6]-[N&H2&+0&D1:5].[c:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-Cl>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D4:3](-[c:4])(-[c:2])-[c:1]|Cl[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[CH3:20][C:21]1([S:22][C@@H:23]2[CH:24]([C:25]([N:26]2[CH:27]1[C:28]#[N:29])=[O:30])[NH2:31])[CH3:32].Cl>CCN(CC)CC.ClCCl>[CH3:20][C:21]1([S:22][C@@H:23]2[CH:24]([C:25]([N:26]2[CH:27]1[C:28]#[N:29])=[O:30])[NH:31][C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)[CH3:32]|US05684143A
3.9.1|[C:5]-[C&H2&+0&D2:4]-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][CH:2]1[CH2:3][C:4]([N:5]=[C:6]([O:7]1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]Br)([CH3:14])[CH3:15].[O:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][o:22]1>[NH4+].O.[Cl-].CCOCC.BrBr.[Mg]>[CH3:14][C:4]1([CH2:3][CH:2]([O:7][C:6](=[N:5]1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:17]([OH:16])[c:18]1[cH:19][cH:20][cH:21][o:22]1)[CH3:1])[CH3:15]|US06924386B2_0130
10.1.5|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[C&H3&D1:3]-[C&H2&+0&D2:2]-[c:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[c:1]|[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8][cH:9][c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[c:16]2=[O:17])[cH:18]1.O=C1CCC(N1[Br:19])=O>O=c1c2ccccc2ccc2cc(ccc21)CBr.Cc1ccc2c(ccc3ccccc3c2=O)c1.ClC(Cl)(Cl)Cl>[CH3:1][CH:2]([Br:19])[c:3]1[cH:4][cH:5][c:6]2[c:16]([c:15]3[cH:14][cH:13][cH:12][cH:11][c:10]3[cH:9][cH:8][c:7]2[cH:18]1)=[O:17]|EP3169672B1_0158
3.9.3|[C:5]-[C&H1&+0&D2:4]=[O&H0&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C:5]-[C&H1&+0&D3:4](-[O&H1&+0&D1:3])-[C&H2&+0&D2:1]-[C:2]|[CH2:1]=[CH:2][CH2:3]Cl.[CH3:4][C:5]1[CH2:6][CH2:7][CH2:8][C:9]([C:10]=1[CH:11]=[O:12])([CH3:13])[CH3:14]>CCOCC.[Mg]>[CH2:1]=[CH:2][CH2:3][CH:11]([OH:12])[C:10]1=[C:5]([CH2:6][CH2:7][CH2:8][C:9]1([CH3:13])[CH3:14])[CH3:4]|US20120190635A1_0183
4.2.8|[C:5]-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[c:2].[O&H1&+0&D1:1]-O>>[C:5]-[C&H1&+0&D3:4]1-[O&H0&+0&D2:1]-[C&H1&+0&D3:3]-1-[c:2]|[O:1]=[C:2]([CH:3]=[CH:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.O[OH:17]>CO.O[Na]>[O:1]=[C:2]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[CH:3]1[O:17][CH:4]1[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|US20080153873A1_0347
1.7.17|[O&H1&+0&D1:5]-[c:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[O&H0&+0&D2:5](-[c:4])-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:13][CH2:14][CH2:15][CH:16]1[CH2:17][O:18]1)[S:19]([CH3:20])(=[O:21])=[O:22].[OH:23][c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30]>c1ccccc1.CN(C)C=O.O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:13][CH2:14][CH2:15][CH:16]([OH:18])[CH2:17][O:23][c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30])[S:19]([CH3:20])(=[O:21])=[O:22]|US20190016735A1_1327
7.6.1|[C:6]-[C&H0&+0&D3:5](-[N:4])=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[C:6]-[C@&H1&+0&D3:5](-[N:4])-[C@@&H1&+0&D3:3](-[C:2])-[C:1]|[O:1]=[C:2]1[CH2:3][CH2:4][C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[NH:11]1>[O-2].[O-2].[Pt+4]>[O:1]=[C:2]1[CH2:3][CH2:4][C@@H:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C@@H:10]2[NH:11]1|US20200385373A1_1569
1.8.12|[C:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-Br.[S&H1&+0&D1:2]-[c:1]>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][C:3](Br)([CH2:4][CH3:5])[C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12].[SH:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Br:20]>O=C1CCC(N1Br)=O.BrBr>[CH3:1][CH2:2][C:3]([CH2:4][CH3:5])([S:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Br:20])[C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12]|US20160108035A1_0148
3.9.37|[C:5]-[C&H2&+0&D2:4]-Br.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][C:2]([CH3:3])=[CH:4][CH2:5][CH2:6][C:7]([CH3:8])=[CH:9][CH2:10][CH2:11][CH:12]([CH3:13])[CH:14]=[O:15].[CH3:16][CH2:17][O:18][C:19](=[O:20])[CH2:21]Br>c1ccccc1.O=S(=O)(O)O.[Zn]>[CH3:16][CH2:17][O:18][C:19](=[O:20])[CH2:21][CH:14]([OH:15])[CH:12]([CH3:13])[CH2:11][CH2:10][CH:9]=[C:7]([CH3:8])[CH2:6][CH2:5][CH:4]=[C:2]([CH3:1])[CH3:3]|EP1098885B1_0079
1.7.17|[O&H2&+0&D0:5].[C:4]-[C&H1&+0&D3:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[O&H1&+0&D1:5]-[C&H1&+0&D3:3](-[C:4])-[C:2]-[O&H1&+0&D1:1]|[OH:1][CH2:2][C:3]12[CH2:4][CH2:5][CH2:6][CH2:7][CH:8]1[O:9]2.[OH2:10]>C1COCCO1.O=S(=O)(O)O.O[Na]>[OH:10][CH:8]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1([OH:9])[CH2:2][OH:1]|US10639378B2_0542
1.8.13|[C:6]-[S&H1&+0&D1:5].[c:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-Cl>>[C:6]-[S&H0&+0&D2:5]-[C&H0&+0&D4:3](-[c:4])(-[c:2])-[c:1]|Cl[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[CH3:20][CH:21]([CH2:22][SH:23])[C:24](=[O:25])[OH:26]>ClCCl>[CH3:20][CH:21]([CH2:22][S:23][C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)[C:24](=[O:25])[OH:26]|EP0777498B1_0215
8.8.5|[C:4]-[C&H1&+0&D2:3]=[O&H0&D1:2].[O&H0&+0&D2:1](-[#11])-[Cl&+]-[O&-]>>[C:4]-[C&H0&+0&D3:3](=[O&H0&D1:2])-[O&H1&+0&D1:1]|[CH3:1][c:2]1[cH:3][cH:4][s:5][c:6]1-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH:13]([CH3:14])[CH:15]=[O:16].O=[Cl][O:17][Na]>O.[Na+].NS(=O)(=O)O.[O-]S(=O)O.ClC(Cl)Cl>[CH3:1][c:2]1[cH:3][cH:4][s:5][c:6]1-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH:13]([CH3:14])[C:15](=[O:16])[OH:17]|US20200399223A1_0212
4.2.8|[C:5]-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[C:2].[O&H1&+0&D1:1]-O>>[C:5]-[C&H1&+0&D3:4]1-[O&H0&+0&D2:1]-[C&H1&+0&D3:3]-1-[C:2]|[CH3:1][CH2:2][CH:3]1[O:4][CH:5]([CH:6]=[CH:7][C:8]1=[O:9])[O:10][CH3:11].O[OH:12]>CO>[CH3:11][O:10][CH:5]1[O:4][CH:3]([C:8]([CH:7]2[O:12][CH:6]12)=[O:9])[CH2:2][CH3:1]|US06129941A
1.2.14|[N&H3&+0&D0:5].[C:4]-[C&H1&+0&D3:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[N&H2&+0&D1:5]-[C&H1&+0&D3:3](-[C:4])-[C:2]-[O&H1&+0&D1:1]|[NH3:1].[CH3:2][CH:3]([CH3:4])[CH2:5][CH2:6][CH2:7][CH:8]([CH3:9])[CH2:10][CH2:11][CH2:12][CH:13]([CH3:14])[CH2:15][CH2:16][CH2:17][C:18]1([O:19][CH:20]1[CH2:21][OH:22])[CH3:23]>>[CH3:2][CH:3]([CH3:4])[CH2:5][CH2:6][CH2:7][CH:8]([CH3:9])[CH2:10][CH2:11][CH2:12][CH:13]([CH3:14])[CH2:15][CH2:16][CH2:17][C:18]([CH3:23])([OH:19])[CH:20]([NH2:1])[CH2:21][OH:22]|US20190160176A1_0533
9.7.334|[c:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D3:1]:1-C-c1:c:c:c:c:c:1>>[c:5]1:[n&H1&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D2:1]:1|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)[CH:8]([CH2:9][CH2:10][c:11]1[cH:12][n:13][cH:14][n:15]1Cc1ccccc1)[c:16]1[cH:17][c:18]([cH:19][c:20]([cH:21]1)[CH3:22])[CH3:23])[CH3:24].Cl>CCO.Cl.[H][H].[Pd]>[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)[CH:8]([CH2:9][CH2:10][c:11]1[cH:12][nH:13][cH:14][n:15]1)[c:16]1[cH:17][c:18]([cH:19][c:20]([cH:21]1)[CH3:22])[CH3:23])[CH3:24]|US06509366B2
1.2.14|[N&H2&+0&D1:5]-[c:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[N&H1&+0&D2:5](-[c:4])-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[Cl:8])[Cl:9].[Cl:10][CH2:11][CH:12]1[CH2:13][O:14]1>Cl.CCO>[OH:14][CH:12]([CH2:11][Cl:10])[CH2:13][NH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[Cl:8])[Cl:9]|US20200129484A1_0588
2.3.11|[N&H2&+0&D1:5]-[c:4].[N:3]=[C&H0&+0&D3:2](-[O:1])-O-c1:c:c:c:c:c:1>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[N:3])-[O:1]|[N-:1]=[N+:2]=[N:3][c:4]1[cH:5][c:6]([cH:7][c:8]([cH:9]1)[NH2:10])[Cl:11].[N:12]#[C:13][N:14]=[C:15](Oc1ccccc1)[O:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>ClC(Cl)Cl>[N-:1]=[N+:2]=[N:3][c:4]1[cH:5][c:6]([cH:7][c:8]([cH:9]1)[NH:10][C:15](=[N:14][C:13]#[N:12])[O:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[Cl:11]|US20190388421A1_1080
10.1.5|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[C&H3&D1:3]-[C&H2&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[C:1]|[CH3:1][CH2:2][CH:3]=[C:4]([C:5](=[O:6])[O:7][CH2:8][CH3:9])[C:10]([CH3:11])=[O:12].O=C1CCC(N1[Br:13])=O>ClC(Cl)(Cl)Cl>[CH3:9][CH2:8][O:7][C:5](=[O:6])[C:4](=[CH:3][CH:2]([CH3:1])[Br:13])[C:10]([CH3:11])=[O:12]|EP2487177A1_0203
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-I.[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[n:5][n:6][c:7]2[cH:8][cH:9][c:10]([n:11][n:12]12)I.[F:13][c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[F:20])-[c:21]1[n:22][c:23]2[CH2:24][CH2:25][CH2:26][n:27]2[c:28]1I>>[CH3:1][CH:2]([CH3:3])[c:4]1[n:5][n:6][c:7]2[cH:8][cH:9][c:10]([n:11][n:12]12)-[c:28]1[c:21]([n:22][c:23]2[CH2:24][CH2:25][CH2:26][n:27]21)-[c:17]1[cH:16][cH:15][c:14]([cH:19][c:18]1[F:20])[F:13]|US08188083B2_0895
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)I.[CH3:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)I>[Cu]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)-[c:15]1[cH:16][cH:17][c:12]([cH:13][cH:14]1)[CH3:11]|US20090069408A1_0668
9.5.4|[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H0&+0&D4:3](-[C:2])(-[c:1])-O>>[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:3](-[C:2])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]12[CH2:6][N:7]([CH2:8][CH:9]1[C:10]([CH2:11][CH2:12][CH:13]2[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)(O)[c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1[CH3:26])[CH2:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>O=S(=O)(O)C(F)(F)F.O[Na].ClCCl>[CH3:26][c:25]1[cH:24][cH:23][cH:22][cH:21][c:20]1[C:10]1[CH2:11][CH2:12][CH:13]([C:5]2([CH2:6][N:7]([CH2:8][C:9]=12)[CH2:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)[C:3](=[O:4])[O:2][CH3:1])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US05108485A
7.9.1|[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C:5]-[C@@&H1&+0&D3:4](-[C:3])-[C&H2&+0&D2:2]-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH:3]([CH:4]=[O:5])[C:6](=[O:7])[O:8][CH2:9][CH3:10]>>[CH3:10][CH2:9][O:8][C:6](=[O:7])[C@H:3]([CH2:2][CH3:1])[CH2:4][OH:5]|EP1568679A1_0112
8.8.18|[C&H2&+0&D2:5]1-[S&H0&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1>>[c&H1&+0&D2:5]1:[s&H0&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1|[CH3:1][n:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[c:9]([c:10]2[CH2:11][S:12][CH2:13][c:14]21)=[O:15]>O=S(=O)(Cl)Cl.ClCCl>[CH3:1][n:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[c:9]([c:10]2[cH:11][s:12][cH:13][c:14]21)=[O:15]|US09783634B2_0071
7.6.1|[c&H1&+0&D2:5]1:[c&H1&+0&D2:4]:[n&H1&+0&D2:3]:[c:2]:[c:1]:1>>[C&H2&+0&D2:5]1-[C&H2&+0&D2:4]-[N&H1&+0&D2:3]-[c:2]:[c:1]-1|[cH:1]1[cH:2][n:3][c:4]2[nH:5][cH:6][cH:7][c:8]2[cH:9]1>>[cH:2]1[cH:1][cH:9][c:8]2[CH2:7][CH2:6][NH:5][c:4]2[n:3]1|US09926282B2_0900
9.7.95|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#29].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[n:6][c:7]([n:8][c:9]([c:10]1[CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[I:18])I)[CH3:19].[N:20]#[C:21][Cu]>ClCCl.c1ccncc1>[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[n:6][c:7]([n:8][c:9]([c:10]1[CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[I:18])[C:21]#[N:20])[CH3:19]|US20200347037A1_0246
9.7.95|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#29].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]1[N:3]=[C:4]([c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[NH:11][C:12]1=[O:13])I)[c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[F:20].[N:21]#[C:22][Cu]>O.CN(C)C=O>[CH3:1][CH:2]1[N:3]=[C:4]([c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[NH:11][C:12]1=[O:13])[C:22]#[N:21])[c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[F:20]|US20050020616A1_0160
3.11.16|[C:6]-[C&H1&+0&D3:5](-[C:4])-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1I)[Cl:15].[CH3:16][C:17]([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH2:24][CH:25]([CH2:26]1)I>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.c1ccc(o1)P(c1ccco1)c1ccco1.C[Si](C)(C)Cl.CN(C)C=O.BrCCBr.[Zn].[Pd]>[CH3:16][C:17]([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH2:24][CH:25]([CH2:26]1)[c:14]1[cH:13][c:12]([cH:11][cH:10][c:9]1[O:8][Si:5]([CH3:7])([CH3:6])[C:2]([CH3:1])([CH3:3])[CH3:4])[Cl:15]|EP2401265B1_0174
8.8.18|[C&H2&+0&D2:5]1-[C&H2&+0&D2:4]-[N&H1&+0&D2:3]-[c:2]:[c:1]-1>>[c&H1&+0&D2:5]1:[c&H1&+0&D2:4]:[n&H1&+0&D2:3]:[c:2]:[c:1]:1|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][cH:11][cH:12][c:13]2[CH2:14][CH2:15][NH:16][c:17]21>O=[Mn]=O.ClCCl>[O:1]=[C:2]([c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1)[c:9]1[cH:10][cH:11][cH:12][c:13]2[cH:14][cH:15][nH:16][c:17]12|US08716303B2_1209
2.1.2|[N&H2&+0&D1:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[s:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[c:13]1[C:14]([O-])=[O:15].[NH2:16][c:17]1[cH:18][cH:19][cH:20][s:21]1>CCBr.CC[Mg]Br.C1CCOC1.[Mg]>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[s:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[c:13]1[C:14](=[O:15])[NH:16][c:17]1[cH:18][cH:19][cH:20][s:21]1|US08288419B2_1597
3.9.28|[C:6]-[C&H0&+0&D3:5](-[c:4])=O.[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[CH2:9][CH2:10][C:11](=O)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[C:18](=O)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[O:25][CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>[Cl-].[Cl-].[Cl-].[Ti+3].[Cu].[Zn]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[C:18](=[C:11]([CH2:10][CH2:9][c:7]2[cH:8]1)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[O:25][CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1|US09309211B2_0200
9.7.82|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][n:4]([cH:5][n:6]1)-[c:7]1[cH:8][c:9]([c:10]([c:11]([cH:12]1)I)[NH2:13])[CH3:14].[N:15]#[C:16][K]>O.CC(C)=O>[CH3:14][c:9]1[cH:8][c:7]([cH:12][c:11]([c:10]1[NH2:13])[C:16]#[N:15])-[n:4]1[cH:5][n:6][c:2]([cH:3]1)[CH3:1]|US20040122001A1_0383
8.8.18|[C&H2&+0&D2:5]1-[C&H2&+0&D2:4]-[c:3]:[c:2]-[O&H0&+0&D2:1]-1>>[c&H1&+0&D2:5]1:[c&H1&+0&D2:4]:[c:3]:[c:2]:[o&H0&+0&D2:1]:1|[CH3:1][O:2][c:3]1[c:4]2[o:5][c:6]([cH:7][cH:8][c:9]2[cH:10][c:11]2[CH2:12][CH2:13][O:14][c:15]21)=[O:16]>[Na+].[Na+].Cc1ccccc1.N#CC1=C(C(C(=C(C1=O)Cl)Cl)=O)C#N.[O-]S(=O)S([O-])=O.O[Na]>[CH3:1][O:2][c:3]1[c:15]2[o:14][cH:13][cH:12][c:11]2[cH:10][c:9]2[cH:8][cH:7][c:6]([o:5][c:4]21)=[O:16]|US20150246902A1_0328
3.9.28|[C:6]-[C&H0&+0&D3:5](-[C:4])=O.[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][cH:11][c:12]2[c:13]([cH:14]1)[C:15]([c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1-2)=O.O=[C:22]1[CH:23]2[CH2:24][CH:25]3[CH2:26][CH:27]1[CH2:28][CH:29]([CH2:30]2)[CH2:31]3>CCN(CC)CC.C1CCOC1.Cl[Ti](Cl)Cl.[H-].[H-].[H-].[H-].[Li+].[Al+3]>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][cH:11][c:12]2-[c:21]3[cH:20][cH:19][cH:18][cH:17][c:16]3[C:15]([c:13]2[cH:14]1)=[C:22]1[CH:23]2[CH2:24][CH:25]3[CH2:31][CH:29]([CH2:28][CH:27]1[CH2:26]3)[CH2:30]2|US09309211B2_0399
9.7.163|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][n:9][c:10]1[C:11](=[O:12])[c:13]1[cH:14][c:15]([c:16]([cH:17][c:18]1[O:19][CH2:20][O:21][CH3:22])F)[F:23].[N:24]#[C:25][K]>O.CCOC(C)=O.CS(C)=O>[CH3:1][O:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][n:9][c:10]1[C:11](=[O:12])[c:13]1[cH:14][c:15]([c:16]([cH:17][c:18]1[O:19][CH2:20][O:21][CH3:22])[C:25]#[N:24])[F:23]|US20110301122A1_1006
1.8.14|[C&H3&D1:5]-[S&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[F:10])F.[CH3:11][S:12][Na]>>[CH3:11][S:12][c:7]1[cH:6][cH:5][c:4]([cH:9][c:8]1[F:10])[C:2]([CH3:1])=[O:3]|EP3133075B1_0220
9.5.4|[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H0&+0&D4:3](-[c:2])(-[c:1])-O>>[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:3](-[c:2])-[c:1]|Cl.[ClH:1].[O:2]=[C:3]([CH2:4][CH2:5][CH2:6][N:7]1[CH2:8][CH2:9][CH:10]([CH2:11][CH2:12]1)[C:13](O)([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:26]1[cH:27][cH:28][c:29]2[cH:30][cH:31][cH:32][cH:33][c:34]2[cH:35]1>CC(C)O>[ClH:1].[O:2]=[C:3]([CH2:4][CH2:5][CH2:6][N:7]1[CH2:8][CH2:9][C:10]([CH2:11][CH2:12]1)=[C:13]([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:26]1[cH:27][cH:28][c:29]2[cH:30][cH:31][cH:32][cH:33][c:34]2[cH:35]1|US20200392125A1_0813
4.2.33|[C:5]-[C&H2&+0&D2:4]-Cl.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H1&+0&D3:4]1-[O&H0&+0&D2:3]-[C&H1&+0&D3:2]-1-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]=[O:10].[CH3:11][CH2:12][O:13][C:14](=[O:15])[CH2:16]Cl>Cc1ccccc1.CCO>[CH3:11][CH2:12][O:13][C:14](=[O:15])[CH:16]1[O:10][CH:9]1[c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[O:2][CH3:1]|EP0860439A1_0020
9.7.163|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[N:1]#[C:2][Na].F[c:3]1[c:4]([c:5]([n:6][c:7]([c:8]1[Cl:9])[F:10])[F:11])[Cl:12]>CN(C)C=O>[N:1]#[C:2][c:3]1[c:8]([c:7]([n:6][c:5]([c:4]1[Cl:12])[F:11])[F:10])[Cl:9]|US20060211735A1_0082
1.7.11|[C&H3&D1:5]-[O&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][Na].[N:3]#[C:4][c:5]1[cH:6][c:7]([c:8]([cH:9][c:10]1F)-[n:11]1[c:12]([c:13]([c:14]([n:15]([c:16]1=[O:17])[NH2:18])[C:19]([F:20])([F:21])[F:22])[Cl:23])=[O:24])[F:25]>F[Na]>[CH3:1][O:2][c:10]1[cH:9][c:8]([c:7]([cH:6][c:5]1[C:4]#[N:3])[F:25])-[n:11]1[c:12]([c:13]([c:14]([n:15]([c:16]1=[O:17])[NH2:18])[C:19]([F:20])([F:21])[F:22])[Cl:23])=[O:24]|EP3484878B1_1354
9.7.163|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([n:6][cH:7]1)F.[N:8]#[C:9][Na]>O.CS(C)=O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([n:6][cH:7]1)[C:9]#[N:8]|US20150225404A1_0699
7.6.1|[c&H1&+0&D2:5]1:[c&H1&+0&D2:4]:[o&H0&+0&D2:3]:[c:2]:[c:1]:1>>[C&H2&+0&D2:5]1-[C&H2&+0&D2:4]-[O&H0&+0&D2:3]-[c:2]:[c:1]-1|[CH3:1][CH:2]([CH3:3])[C:4]1([N:5]=[C:6]([NH:7][C:8]1=[O:9])[c:10]1[n:11][c:12]2[o:13][cH:14][cH:15][c:16]2[cH:17][c:18]1[C:19](=[O:20])[OH:21])[CH3:22]>O.CCO.O=C(O[K])O[K].[H][H].[Pd]>[CH3:1][CH:2]([CH3:3])[C:4]1([N:5]=[C:6]([NH:7][C:8]1=[O:9])[c:10]1[n:11][c:12]2[O:13][CH2:14][CH2:15][c:16]2[cH:17][c:18]1[C:19](=[O:20])[OH:21])[CH3:22]|US03963717A
9.7.82|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[N:1]#[C:2][Na].[NH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1I)[F:10]>[C-]#N.c1ccncc1.[Cu+]>[N:1]#[C:2][c:9]1[cH:8][c:7]([cH:6][cH:5][c:4]1[NH2:3])[F:10]|US20050026915A1_0681
9.5.4|[C:6]-[C&H1&+0&D3:5](-[c:4])-[C&H0&+0&D4:3](-[C:2])(-[c:1])-O>>[C:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:3](-[C:2])-[c:1]|O[C:1]1([C:2](=[C:3]([CH:4]([CH:5]1[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>Cl.[OH2-]>[cH:33]1[cH:32][cH:31][c:30]([cH:35][cH:34]1)[C:1]1[C:2](=[C:3]([CH:4]([C:5]=1[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1|US20040034017A1_0268
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[cH:9][c:10]([n:11][cH:12][c:13]1[C:14](=[O:15])[N:16]([CH3:17])[CH2:18][c:19]1[cH:20][c:21]([cH:22][c:23]([cH:24]1)[C:25]([F:26])([F:27])[F:28])[C:29]([F:30])([F:31])[F:32])I.[CH3:33][c:34]1[cH:35][c:36]([cH:37][cH:38][n:39]1)I>CC1(OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C)C.c1ccc(cc1)P(c1ccccc1)c1cc[cH-]c1.c1ccc(cc1)P(c1ccccc1)c1cc[cH-]c1.O=C(O[Na])O[Na].CN(C)C=O.O=C(O)O[Na].CC([O-])=O.Cl[Pd]Cl.[K+].[Fe+2]>[CH3:33][c:34]1[cH:35][c:36]([cH:37][cH:38][n:39]1)-[c:10]1[cH:9][c:8]([c:13]([cH:12][n:11]1)[C:14](=[O:15])[N:16]([CH3:17])[CH2:18][c:19]1[cH:20][c:21]([cH:22][c:23]([cH:24]1)[C:25]([F:26])([F:27])[F:28])[C:29]([F:30])([F:31])[F:32])-[c:7]1[cH:6][cH:5][cH:4][cH:3][c:2]1[CH3:1]|US08987307B2_0959
9.7.41|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[N:1]#[C:2][Na].[O-:3][N+:4](=[O:5])[c:6]1[c:7]2[cH:8][n:9][cH:10][cH:11][c:12]2[cH:13][cH:14][c:15]1Cl>O.[C-]#N.CN1CCCC1=O.[Cu+]>[N:1]#[C:2][c:15]1[cH:14][cH:13][c:12]2[cH:11][cH:10][n:9][cH:8][c:7]2[c:6]1[N+:4]([O-:3])=[O:5]|EP0787124B1_0027
1.8.12|[C&H3&D1:5]-[S&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][NH:2][CH2:3][c:4]1[cH:5][c:6]([c:7]([cH:8][c:9]1[O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[O:17][C:18]([F:19])([F:20])[F:21])Br)[S:22]([NH2:23])(=[O:24])=[O:25].[CH3:26][S:27][Na]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CS(C)=O>[CH3:1][NH:2][CH2:3][c:4]1[cH:5][c:6]([c:7]([cH:8][c:9]1[O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[O:17][C:18]([F:19])([F:20])[F:21])[S:27][CH3:26])[S:22]([NH2:23])(=[O:24])=[O:25]|US20200087323A1_0624
9.7.41|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#19].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|Cl[c:1]1[n:2][c:3]2[CH2:4][CH2:5][CH2:6][CH2:7][c:8]2[c:9]2[n:10][c:11]([cH:12][n:13]21)-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[N:20]#[C:21][K]>C1COCCOCCOCCOCCOCCO1.CC#N.O>[N:20]#[C:21][c:1]1[n:2][c:3]2[CH2:4][CH2:5][CH2:6][CH2:7][c:8]2[c:9]2[n:10][c:11]([cH:12][n:13]12)-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US20200095261A1_0387
1.7.11|[C&H3&D1:5]-[O&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][NH:10][c:11]1[cH:12][n:13][cH:14][c:15]([n:16]1)Cl.[CH3:17][O:18][Na]>>[CH3:17][O:18][c:15]1[cH:14][n:13][cH:12][c:11]([n:16]1)[NH:10][CH2:9][c:6]1[cH:7][cH:8][c:3]([cH:4][cH:5]1)[O:2][CH3:1]|EP3057950B1_0368
9.7.95|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#29].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH:2]1[CH2:3][C:4]([NH:5][c:6]2[n:7][c:8]([c:9]3[n:10][cH:11][cH:12][cH:13][c:14]3[c:15]21)Br)=[O:16].[N:17]#[C:18][Cu]>O.[C-]#N.CO.[K+]>[CH3:1][CH:2]1[CH2:3][C:4]([NH:5][c:6]2[n:7][c:8]([c:9]3[n:10][cH:11][cH:12][cH:13][c:14]3[c:15]21)[C:18]#[N:17])=[O:16]|US20200165280A1_0249
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([n:7]1)I)-[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[C:14]([F:15])([F:16])[F:17].Cl[c:18]1[cH:19][cH:20][n:21][c:22]([n:23]1)[Cl:24]>>[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([n:7]1)-[c:18]1[cH:19][cH:20][n:21][c:22]([n:23]1)[Cl:24])-[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[C:14]([F:15])([F:16])[F:17]|US20160046610A1_1082
3.11.16|[C:6]-[C&H1&+0&D3:5](-[C:4])-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)I.Br[c:14]1[cH:15][cH:16][n:17][cH:18][cH:19]1>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.c1ccc(o1)P(c1ccco1)c1ccco1.Oc1ccc(cc1)O.CN(C)C=O.ClCCl.[Zn].[Pd].[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[c:14]1[cH:15][cH:16][n:17][cH:18][cH:19]1|US09181271B2_0936
9.7.41|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[N:1]#[C:2][K].[O:3]=[c:4]1[c:5]([n:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n:13]1-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20])Cl>O.CN(C)C=O>[N:1]#[C:2][c:5]1[n:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n:13]([c:4]1=[O:3])-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20]|US20200353101A1_0653
9.7.95|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#29].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[N:1]#[C:2][Cu].[O-:3][N+:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([c:10]([cH:11]1)[N+:12]([O-:13])=[O:14])Cl>CN1CCCC1=O>[N:1]#[C:2][c:9]1[n:8][cH:7][c:6]([cH:11][c:10]1[N+:12]([O-:13])=[O:14])[N+:4]([O-:3])=[O:5]|US20080269281A1_0111
9.7.41|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#11].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][N:2]([CH3:3])[c:4]1[n:5][c:6]([n:7][c:8]([n:9]1)Cl)[NH:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17].[N:18]#[C:19][Na]>CN(C)C=O>[CH3:1][N:2]([CH3:3])[c:4]1[n:5][c:6]([n:7][c:8]([n:9]1)[C:19]#[N:18])[NH:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]|US20190218200A1_0335
3.9.83|[C:5]-[C&H2&+0&D2:4]-[#3].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|CCCCCC.[CH3:1][O:2][c:3]1[c:4]([c:5]([c:6]([c:7]([c:8]1[CH:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15](=[O:16])[O:17][CH3:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25])[CH3:26])[CH:27]=[O:28])[CH3:29])[CH3:30].[CH3:31][CH2:32][CH2:33][CH2:34][Li]>[O-]S(=O)(=O)O.C1CCOC1.[K+]>[CH3:18][O:17][C:15](=[O:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH:9]([c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25])[c:8]1[c:3]([c:4]([c:5]([c:6]([c:7]1[CH3:26])[CH:27]([OH:28])[CH2:34][CH2:33][CH2:32][CH3:31])[CH3:29])[CH3:30])[O:2][CH3:1]|US07994203B2_0560
1.2.20|[N&H2&+0&D1:5]-[c:4]:[c:3]/[C&H1&+0&D2:2]=[C&H1&+0&D2:1]/O-C>>[n&H1&+0&D2:5]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c:3]:[c:4]:1|CO/[CH:1]=[CH:2]/[c:3]1[c:4]([n:5][cH:6][n:7][c:8]1[NH2:9])[Cl:10]>Cl.C1CCOC1>[Cl:10][c:4]1[n:5][cH:6][n:7][c:8]2[nH:9][cH:1][cH:2][c:3]12|US20190241573A1_0739
9.7.41|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][n:9]([c:10]1Cl)-[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[C:17]([F:18])([F:19])[F:20])[Cl:21].[N:22]#[C:23][Na]>CN(C)C=O.O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][n:9]([c:10]1[C:23]#[N:22])-[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[C:17]([F:18])([F:19])[F:20])[Cl:21]|US20180162844A1_0344
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[c&H0&+0&D3:2](:[s:1])-I>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][c:7]([cH:8][n:9][c:10]1[Cl:11])Br.[CH3:12][C:13](=[O:14])[NH:15][c:16]1[n:17][c:18]([c:19]([s:20]1)I)[CH3:21]>CC1(OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C)C.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.O=C(O[Na])O[Na].C1COCCO1.CC([O-])=O.CCO.ClCCl.Cl[Pd]Cl.[K+].[Fe+2]>[CH3:12][C:13](=[O:14])[NH:15][c:16]1[n:17][c:18]([c:19]([s:20]1)-[c:7]1[cH:8][n:9][c:10]([c:5]([cH:6]1)[S:2]([CH3:1])(=[O:3])=[O:4])[Cl:11])[CH3:21]|US09896443B2_0396
9.7.25|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[CH:12]([CH2:13][CH:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1)[C:20](=[O:21])[NH:22][c:23]1[cH:24][n:25][c:26]([cH:27][n:28]1)Br.[N:29]#[C:30][K]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1COCCOCCOCCOCCOCCO1.CN(C)C=O.I[Cu]>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[CH:12]([CH2:13][CH:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1)[C:20](=[O:21])[NH:22][c:23]1[cH:24][n:25][c:26]([cH:27][n:28]1)[C:30]#[N:29]|US09469656B2_0175
1.8.13|[C&H3&D1:5]-[S&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][n:6][c:7]([c:8]([cH:9]1)[Cl:10])Cl.[CH3:11][S:12][Na]>CC(C)(C)O>[CH3:11][S:12][c:7]1[n:6][cH:5][c:4]([cH:9][c:8]1[Cl:10])[C:2]([CH3:1])=[O:3]|US20200010453A1_0485
1.7.11|[C&H3&D1:5]-[O&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][c:8]([c:9]1Cl)[N+:10]([O-:11])=[O:12])[C:13]([F:14])([F:15])[F:16].[CH3:17][O:18][Na]>>[CH3:17][O:18][c:9]1[c:8]([cH:7][c:6]([cH:5][c:4]1[N+:2]([O-:1])=[O:3])[C:13]([F:14])([F:15])[F:16])[N+:10]([O-:11])=[O:12]|EP3300500B1_1437
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([n:6]1-[c:7]1[cH:8][cH:9][cH:10][c:11]([n:12]1)Br)[CH3:13].[Cl:14][CH2:15][CH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)I>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCCCCC.CCOCC.CCCC[Li].C1CCOC1.Cl[Zn]Cl>[CH3:1][c:2]1[cH:3][cH:4][c:5]([n:6]1-[c:7]1[cH:8][cH:9][cH:10][c:11]([n:12]1)-[c:20]1[cH:19][cH:18][c:17]([cH:22][cH:21]1)[CH2:16][CH2:15][Cl:14])[CH3:13]|EP3070085A1_0128
3.11.13|[c:6]:[c&H0&+0&D3:5](:[s:4])-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]1([CH2:3][O:4][C:5](=[N:6]1)[CH:7]([CH3:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)I)[CH3:15].[CH3:16][c:17]1[cH:18][cH:19][s:20][c:21]1Br>c1ccccc1.C1CCOC1.CC(=O)O.O.[Cl-].[Cl-].[Mg].[Pd+2]>[CH3:16][c:17]1[cH:18][cH:19][s:20][c:21]1-[c:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[CH:7]([CH3:8])[C:5]1=[N:6][C:2]([CH2:3][O:4]1)([CH3:1])[CH3:15]|EP1869049B1_0349
9.7.41|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#19].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[s:1]|[OH:1][c:2]1[cH:3][cH:4][c:5]2[n:6][c:7]([s:8][c:9]2[cH:10]1)Cl.[N:11]#[C:12][K]>C1COCCOCCOCCOCCOCCO1.CS(C)=O.O.Cl>[N:11]#[C:12][c:7]1[n:6][c:5]2[cH:4][cH:3][c:2]([cH:10][c:9]2[s:8]1)[OH:1]|US09587266B2_0227
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-I.[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)I.Br[c:12]1[n:13][cH:14][cH:15][s:16]1>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)O)CC(=O)O.CCCCCC.CCOCC.CCCC[Li].C1CCOC1.[O-]C(=O)O.Cl[Zn]Cl.O.O.[Na+].[Na+].[Na+]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[n:13][cH:14][cH:15][s:16]1|EP2945623B1_0227
1.6.4|[N&H2&+0&D1:6]-[c:5].[c:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-Cl>>[N&H1&+0&D2:6](-[c:5])-[C&H0&+0&D4:3](-[c:4])(-[c:2])-[c:1]|Cl[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[CH3:20][CH2:21][O:22][N:23]=[C:24]([C:25](=[O:26])[O:27][CH2:28][CH3:29])[c:30]1[cH:31][s:32][c:33]([n:34]1)[NH2:35]>CCN(CC)CC.CN(C)C=O.ClCCl.Cl>[CH3:20][CH2:21][O:22][N:23]=[C:24]([C:25](=[O:26])[O:27][CH2:28][CH3:29])[c:30]1[cH:31][s:32][c:33]([n:34]1)[NH:35][C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|US20100331397A1_0292
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]2[c:7]1[nH:8][c:9]([cH:10][cH:11]2)=[O:12])-[n:13]1[cH:14][c:15]([n:16][c:17]1[CH3:18])I.[F:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)Br>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCCCCC.CCCC[Li].C1CCOC1.Cl[Zn]Cl>[CH3:18][c:17]1[n:16][c:15]([cH:14][n:13]1-[c:4]1[cH:5][c:6]2[cH:11][cH:10][c:9]([nH:8][c:7]2[c:2]([cH:3]1)[CH3:1])=[O:12])-[c:23]1[cH:22][cH:21][c:20]([cH:25][cH:24]1)[F:19]|US20200407327A1_0488
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][Si:3]([CH2:4][CH3:5])([CH2:6][CH3:7])[O:8][C:9]([CH3:10])([CH3:11])[c:12]1[cH:13][cH:14][n:15]2[c:16]([n:17][cH:18][c:19]2Br)[n:20]1.I[c:21]1[cH:22][cH:23][n:24][c:25]([n:26]1)[I:27]>>[CH3:1][CH2:2][Si:3]([CH2:4][CH3:5])([CH2:6][CH3:7])[O:8][C:9]([CH3:10])([CH3:11])[c:12]1[cH:13][cH:14][n:15]2[c:19]([cH:18][n:17][c:16]2[n:20]1)-[c:21]1[cH:22][cH:23][n:24][c:25]([n:26]1)[I:27]|US09096592B2_0864
1.7.11|[C&H3&D1:5]-[O&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]2[CH2:5][CH2:6][CH2:7][C:8]([c:9]2[c:10]([c:11]1[OH:12])Br)([CH3:13])[CH3:14].[CH3:15][O:16][Na]>Br[Cu]>[CH3:15][O:16][c:10]1[c:11]([c:2]([cH:3][c:4]2[CH2:5][CH2:6][CH2:7][C:8]([c:9]21)([CH3:13])[CH3:14])[CH3:1])[OH:12]|US20200038374A1_1354
9.7.25|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[n:12]1)Br.[N:13]#[C:14][K]>CC([O-])=O.CC([O-])=O.CN(C)C=O.O[K].[Pd+2]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[n:12]1)[C:14]#[N:13]|US20160024083A1_0204
1.3.7|[c:6]:[c&H0&+0&D3:5](:[c:4])-Cl.[C:3]1-[C:2]-[N&H1&+0&D2:1]-1>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[N&H0&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([c:7]([c:8]([n:9][c:10]1[C:11]([F:12])([F:13])[Cl:14])[C:15]([F:16])([F:17])[F:18])[C:19](=[O:20])[O:21][CH2:22][CH3:23])Cl.[CH3:24][CH:25]1[CH2:26][NH:27]1>CCN(CC)CC.CN(C)C=O.[O-]C([O-])=O.O.[K+].[K+]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:10]([n:9][c:8]([c:7]([c:6]1[N:27]1[CH2:26][CH:25]1[CH3:24])[C:19](=[O:20])[O:21][CH2:22][CH3:23])[C:15]([F:16])([F:17])[F:18])[C:11]([F:13])([F:12])[Cl:14]|EP0182769B1_0150
3.11.16|[C:6]-[C&H1&+0&D3:5](-[C:4])-I.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|Cl[c:1]1[n:2][cH:3][cH:4][n:5][c:6]1[Cl:7].I[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12]1>CC(=O)N(C)C.C[Si](C)(C)Cl.BrCCBr.I[Cu].[Zn]>[Cl:7][c:6]1[n:5][cH:4][cH:3][n:2][c:1]1[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12]1|US20160280703A1_0473
3.11.16|[C:6]-[C&H1&+0&D3:5](-[C:4])-I.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|Br[c:1]1[n:2][cH:3][cH:4][c:5]2[c:6]1[cH:7][cH:8][n:9]2[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[CH3:17][C:18]([CH3:19])([CH3:20])[O:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][CH:27]([CH2:28][CH2:29]1)I>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.c1ccc(o1)P(c1ccco1)c1ccco1.C1CCOC1.C1CCOC1.BrCCBr.CNC.[Zn].[Pd].[Pd]>[CH3:17][C:18]([CH3:19])([CH3:20])[O:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][CH:27]([CH2:28][CH2:29]1)[c:1]1[n:2][cH:3][cH:4][c:5]2[c:6]1[cH:7][cH:8][n:9]2[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US20200170997A1_0176
9.7.95|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#29].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][c:2]1[o:3][n:4][c:5]([c:6]1[C:7](=[O:8])[N:9]([CH3:10])[CH2:11][c:12]1[n:13][c:14]([s:15][c:16]1Br)[NH:17][C:18](=[O:19])[NH:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][c:26]([cH:27]1)[F:28])[CH3:29].[N:30]#[C:31][Cu]>[C-]#N.CN(C)C=O.CCOC(C)=O.[K+]>[CH3:1][c:2]1[o:3][n:4][c:5]([c:6]1[C:7](=[O:8])[N:9]([CH3:10])[CH2:11][c:12]1[n:13][c:14]([s:15][c:16]1[C:31]#[N:30])[NH:17][C:18](=[O:19])[NH:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][c:26]([cH:27]1)[F:28])[CH3:29]|US20090099200A1_0301
9.7.95|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#29].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][c:6]1[cH:7][n:8][c:9]([n:10][cH:11]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)-[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)Br.[N:24]#[C:25][Cu]>CN(C)C=O.NCCN>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][c:6]1[cH:7][n:8][c:9]([n:10][cH:11]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)-[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[C:25]#[N:24]|US09309265B2_0448
9.7.95|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#29].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[c:3]([cH:4][cH:5][c:6]([c:7]1Cl)[N+:8]([O-:9])=[O:10])[Cl:11].[N:12]#[C:13][Cu]>O.CS(C)=O>[CH3:1][c:2]1[c:3]([cH:4][cH:5][c:6]([c:7]1[C:13]#[N:12])[N+:8]([O-:9])=[O:10])[Cl:11]|US09126931B2_3346
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[N+:10]([O-:11])=[O:12])Br.[F:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)I>>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[N+:10]([O-:11])=[O:12])-[c:17]1[cH:16][cH:15][c:14]([cH:19][cH:18]1)[F:13]|US08507489B2_0462
9.7.25|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[n:4][s:5][cH:6][c:7]1Br.[N:8]#[C:9][Na]>O.[C-]#N.CN(C)C=O.[Cu+]>[CH3:1][O:2][c:3]1[n:4][s:5][cH:6][c:7]1[C:9]#[N:8]|US20100197657A1_0125
1.8.13|[C&H3&D1:5]-[S&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[C:9](=[O:10])[c:11]1[n:12][n:13][c:14]([cH:15][c:16]1Cl)[Cl:17].[CH3:18][S:19][Na]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[C:9](=[O:10])[c:11]1[n:12][n:13][c:14]([cH:15][c:16]1[S:19][CH3:18])[Cl:17]|US20200148689A1_1719
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([c:8]([c:9]([cH:10]1)[N+:11]([O-:12])=[O:13])Cl)[N+:14]([O-:15])=[O:16].I[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>[Cu]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([c:8]([c:9]([cH:10]1)[N+:11]([O-:12])=[O:13])-[c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1)[N+:14]([O-:15])=[O:16]|US20200361963A1_0391
3.11.13|[C:6]-[C&H0&+0&D3:5](=[C:4])-F.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H0&+0&D3:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[s:9][c:10]([c:11]2Br)[CH3:12].F[C:13]1=[C:14]([C:15]([C:16]([C:17]1([F:18])[F:19])([F:20])[F:21])([F:22])[F:23])[F:24]>CCCCCC.CCCC[Li].C1CCOC1.O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[s:9][c:10]([c:11]2[C:13]1=[C:14]([C:15]([C:16]([C:17]1([F:18])[F:19])([F:20])[F:21])([F:22])[F:23])[F:24])[CH3:12]|EP2760969B1_0215
1.7.11|[C&H3&D1:5]-[O&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][Na].[Br:3][c:4]1[cH:5][n:6][c:7]([cH:8][n:9]1)Br>>[CH3:1][O:2][c:7]1[cH:8][n:9][c:4]([cH:5][n:6]1)[Br:3]|US20200247784A1_0382
9.7.41|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#19].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[N:1]#[C:2][K].Cl[c:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[n:10][c:11]2[cH:12][c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3[cH:19][c:20]21>[C-]#N.CO.[Cu+]>[N:1]#[C:2][c:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[n:10][c:11]2[cH:12][c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3[cH:19][c:20]21|US20080125427A1_0222
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][S:2][c:3]1[n:4][c:5]2[c:6]([cH:7][cH:8][c:9]([n:10]2-[c:11]2[c:12]([cH:13][cH:14][cH:15][c:16]2[F:17])[F:18])=[O:19])[c:20]([n:21]1)Cl.[CH3:22][c:23]1[cH:24][cH:25][c:26]([cH:27][c:28]1I)[NH2:29]>CC(=O)O[Pd]OC(C)=O.CC1(O[B]OC1(C)C)C.CCN(CC)CC.C1COCCO1.O.O.O.O.O.O.O.O.O.[OH-].[OH-].[Ba+2]>[CH3:1][S:2][c:3]1[n:21][c:20]([c:6]2[cH:7][cH:8][c:9]([n:10]([c:5]2[n:4]1)-[c:11]1[c:12]([cH:13][cH:14][cH:15][c:16]1[F:17])[F:18])=[O:19])-[c:28]1[cH:27][c:26]([cH:25][cH:24][c:23]1[CH3:22])[NH2:29]|EP1581229B1_0062
3.11.89|[C&H3&+0&D1:5]-[#3].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C&H3&+0&D1:5]-[C&H1&+0&D3:2](-[C:1])-[C&H2&+0&D2:3]-[C:4]|[CH3:1][Li].[O:2]=[C:3]1[CH:4]=[CH:5][CH:6]([CH2:7][CH2:8]1)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>[NH4+].O.[Cl-].CCOCC.Br[Cu]>[CH3:1][CH:5]1[CH2:4][C:3]([CH2:8][CH2:7][CH:6]1[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)=[O:2]|US20170057996A1_0361
1.7.11|[C&H3&D1:5]-[O&H0&+0&D2:4]-[#11].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][Na].[O-:3][N+:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([n:10][cH:11]1)Cl>>[CH3:1][O:2][c:9]1[n:10][cH:11][c:6]([cH:7][n:8]1)[N+:4]([O-:3])=[O:5]|US10577382B2_0990
1.8.13|[C&H3&D1:5]-[S&H0&+0&D2:4]-[#11].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[S&H0&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][N:2]([NH:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[c:12]1[n:13][c:14]([n:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21)Cl.[CH3:22][S:23][Na]>>[CH3:22][S:23][c:14]1[n:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[c:12]([n:13]1)[N:2]([CH3:1])[NH:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1|US20200267980A1_0174
9.7.25|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#11].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[N:1]#[C:2][Na].[F:3][c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1-[n:10]1[n:11][c:12]2[CH2:13][CH2:14][CH2:15][CH2:16][c:17]2[c:18]1Br)[Cl:19]>O.[C-]#N.CN1CCCC1=O.[Cu+]>[N:1]#[C:2][c:18]1[c:17]2[CH2:16][CH2:15][CH2:14][CH2:13][c:12]2[n:11][n:10]1-[c:9]1[cH:8][cH:7][c:6]([cH:5][c:4]1[F:3])[Cl:19]|US20200078345A1_0132
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1-[c:9]1[cH:10][cH:11][cH:12][c:13]([n:14]1)Br.[F:15][C:16]([F:17])([F:18])[c:19]1[cH:20][cH:21][c:22]2[c:23]([n:24]1)[n:25][cH:26][cH:27][c:28]2Cl>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.COCCOC.C[Sn](C)C.C[Sn](C)C>[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1-[c:9]1[cH:10][cH:11][cH:12][c:13]([n:14]1)-[c:28]1[cH:27][cH:26][n:25][c:23]2[c:22]1[cH:21][cH:20][c:19]([n:24]2)[C:16]([F:15])([F:17])[F:18]|US20190241558A1_0710
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][Si:3]([CH2:4][CH3:5])([CH2:6][CH3:7])[O:8][C:9]([CH3:10])([CH3:11])[c:12]1[cH:13][cH:14][n:15]2[c:16]([n:17]1)[n:18][cH:19][c:20]2Br.[F:21][C:22]([F:23])([F:24])[c:25]1[n:26][cH:27][cH:28][c:29]([n:30]1)Cl>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCCC[Sn](Cl)(CCCC)CCCC.CC(C)[Mg]Cl.C1CCOC1>[CH3:1][CH2:2][Si:3]([CH2:4][CH3:5])([CH2:6][CH3:7])[O:8][C:9]([CH3:10])([CH3:11])[c:12]1[cH:13][cH:14][n:15]2[c:20]([cH:19][n:18][c:16]2[n:17]1)-[c:29]1[cH:28][cH:27][n:26][c:25]([n:30]1)[C:22]([F:21])([F:23])[F:24]|EP3148995B1_0397
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1Br)[Br:10].[O-:11][N+:12](=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1Br>[O-][N+](=O)c1ccccc1.[Cu]>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1-[c:19]1[cH:18][cH:17][cH:16][cH:15][c:14]1[N+:12]([O-:11])=[O:13])[Br:10]|US09834541B2_0303
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[c:11]([c:12]([n:13]2[CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1)Br)[CH3:19].Br[c:20]1[cH:21][cH:22][cH:23][cH:24][n:25]1>COB(OC)OC.O=C(O[K])O[K].CCCC[Li].CC([O-])=O.CC([O-])=O.[Pd+2]>[CH3:19][c:11]1[c:9]2[cH:10][c:5]([cH:6][cH:7][c:8]2[n:13]([c:12]1-[c:20]1[cH:21][cH:22][cH:23][cH:24][n:25]1)[CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1)[C:3](=[O:4])[O:2][CH3:1]|US09034882B2_0378
3.11.31|[C&H3&+0&D1:5]-[N&+:4].[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H2&+0&D2:5](-[N&+:4])-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][N+:2]([O-:3])=[O:4].[CH3:5][O:6][C:7](=[O:8])[CH2:9][CH2:10][CH2:11][CH2:12][CH:13]=[O:14]>CO.O[Na]>[CH3:5][O:6][C:7](=[O:8])[CH2:9][CH2:10][CH2:11][CH2:12][CH:13]([OH:14])[CH2:1][N+:2]([O-:3])=[O:4]|US10421743B2_0720
1.3.5|[c:6]:[c&H0&+0&D3:5](:[c:4])-B(-O)-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]1([CH2:3][C:4]([c:5]2[c:6]([cH:7][nH:8][c:9]2[CH2:10]1)[CH2:11][CH3:12])=[O:13])[CH3:14].OB(O)[c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[F:21]>CCN(CC)CC.CC([O-])=O.CC([O-])=O.ClCCl.[Cu+2]>[CH3:12][CH2:11][c:6]1[cH:7][n:8]([c:9]2[CH2:10][C:2]([CH2:3][C:4]([c:5]12)=[O:13])([CH3:1])[CH3:14])-[c:15]1[cH:20][c:19]([cH:18][cH:17][cH:16]1)[F:21]|US20080249091A1_0310
3.11.13|[c:6]:[c&H0&+0&D3:5](:[s:4])-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|Br[c:1]1[cH:2][cH:3][n:4][cH:5][cH:6]1.Br[c:7]1[cH:8][cH:9][cH:10][s:11]1>Cl[Ni]1([P](CCC[P]1(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1)Cl.C1CCOC1.Cl.[Mg]>[cH:10]1[cH:9][cH:8][c:7]([s:11]1)-[c:1]1[cH:6][cH:5][n:4][cH:3][cH:2]1|US07199119B2_0273
3.11.16|[C:6]-[C&H1&+0&D3:5](-[C:4])-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|Br[c:1]1[cH:2][cH:3][cH:4][c:5]([cH:6]1)[N:7]([CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.Br[CH:22]1[CH2:23][CH2:24][CH2:25][CH2:26]1>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.CCOCC.C1CCOC1.Cl[Pd]Cl.Br[Zn]Br.[Mg].[Fe+2]>[cH:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[CH2:8][N:7]([CH2:15][c:16]1[cH:21][cH:20][cH:19][cH:18][cH:17]1)[c:5]1[cH:4][cH:3][cH:2][c:1]([cH:6]1)[CH:22]1[CH2:23][CH2:24][CH2:25][CH2:26]1|US20180037570A1_0418
1.3.5|[S:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-B(-O)-O>>[S:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[S:2]1([NH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH2:10][N:11]1[CH2:12][CH2:13][CH2:14][Cl:15])=[O:16].OB(O)[c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)[F:23]>>[O:1]=[S:2]1([N:3]([c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH2:10][N:11]1[CH2:12][CH2:13][CH2:14][Cl:15])[c:17]1[cH:22][c:21]([cH:20][cH:19][cH:18]1)[F:23])=[O:16]|US20080171737A1_0960
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|Br[c:1]1[cH:2][cH:3][cH:4][c:5]([n:6]1)[Br:7].Br[c:8]1[n:9][cH:10][cH:11][cH:12][n:13]1>>[Br:7][c:5]1[cH:4][cH:3][cH:2][c:1]([n:6]1)-[c:8]1[n:13][cH:12][cH:11][cH:10][n:9]1|EP3464273B9_0190
9.5.4|[C&H2&+0&D2:5]1-[c:4]:[c:3]-[O&H0&+0&D2:2]-[C&H1&+0&D3:1]-1-O>>[c&H1&+0&D2:5]1:[c:4]:[c:3]:[o&H0&+0&D2:2]:[c&H1&+0&D2:1]:1|[CH3:1][O:2][c:3]1[c:4]2[o:5][c:6]([cH:7][cH:8][c:9]2[cH:10][c:11]2[CH2:12][CH:13]([O:14][c:15]12)O)=[O:16]>O=CO>[CH3:1][O:2][c:3]1[c:15]2[o:14][cH:13][cH:12][c:11]2[cH:10][c:9]2[cH:8][cH:7][c:6]([o:5][c:4]21)=[O:16]|US08063099B2_0592
1.3.5|[C:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-B(-O)-O>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]1[C:3]([NH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12)=[O:11].OB(O)[c:12]1[cH:13][cH:14][s:15][cH:16]1>CCN(CC)CC.CC([O-])=O.CC([O-])=O.ClCCl.[Cu+2]>[O:1]=[C:2]1[C:3]([N:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12)[c:12]1[cH:13][cH:14][s:15][cH:16]1)=[O:11]|EP2516435B1_0382
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][c:9]2[c:10]1[O:11][C:12]([O:13]2)([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)Br.Br[c:26]1[n:27][cH:28][cH:29][s:30]1>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CC1(OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C)C.CC([O-])=O.[O-]C([O-])=O.[K+].[K+].[K+]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][c:9]2[c:10]1[O:11][C:12]([O:13]2)([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)-[c:26]1[n:27][cH:28][cH:29][s:30]1|EP3070081A1_0680
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[Cl:1][c:2]1[n:3][c:4]([n:5][c:6]([n:7]1)[Cl:8])Cl.Br[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>Cc1ccccc1.C1CCOC1.II.Cl>[Cl:8][c:6]1[n:7][c:2]([n:3][c:4]([n:5]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[Cl:1]|US20200255407A1_0933
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][n:9]2[c:10]1[c:11]([n:12][c:13]([n:14]2)Cl)[O:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[F:22][c:23]1[cH:24][cH:25][c:26]([n:27][cH:28]1)Br>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1COCCO1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][n:9]2[c:10]1[c:11]([n:12][c:13]([n:14]2)-[c:26]1[cH:25][cH:24][c:23]([cH:28][n:27]1)[F:22])[O:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US10336761B2_0864
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1Cl.[CH3:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)Br>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccncc1.[Cl-].[Cl-].[Ni+2].[Zn]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1-[c:15]1[cH:14][cH:13][c:12]([cH:17][cH:16]1)[CH3:11]|US20200039935A1_0275
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[cH:11][cH:12][c:13]([n:14][n:15]1)Cl.[CH3:16][O:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)Br>Cl[Ni]Cl.C1CCOC1.[Mg]>[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[cH:11][cH:12][c:13]([n:14][n:15]1)-[c:21]1[cH:22][cH:23][c:18]([cH:19][cH:20]1)[O:17][CH3:16]|US09409905B2_0808
3.9.6|[C&H3&+0&D1:5]-I.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C@@H:12]1[C@H:13]([CH2:14][CH:15]2[O:16][CH2:17][CH2:18][O:19][CH:20]21)[CH2:21][CH2:22][C:23](=[O:24])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29].[CH3:30]I>[NH4+].O.[Cl-].CCOCC.[Mg]>[CH3:29][CH2:28][CH2:27][CH2:26][CH2:25][C:23]([CH3:30])([OH:24])[CH2:22][CH2:21][C@H:13]1[CH2:14][CH:15]2[O:16][CH2:17][CH2:18][O:19][CH:20]2[C@@H:12]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:4](=[O:5])[O:3][CH2:2][CH3:1]|EP0373556A2_0064
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1-[c:10]1[n:11][c:12]2[c:13]([n:14][n:15]([c:16]2[c:17]([nH:18]1)=[O:19])[CH3:20])[CH2:21][CH2:22][CH3:23])Br.Br[c:24]1[cH:25][cH:26][cH:27][cH:28][n:29]1>>[CH3:1][CH2:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1-[c:10]1[n:11][c:12]2[c:13]([n:14][n:15]([c:16]2[c:17]([nH:18]1)=[O:19])[CH3:20])[CH2:21][CH2:22][CH3:23])-[c:24]1[cH:25][cH:26][cH:27][cH:28][n:29]1|US10550102B2_1061
3.11.34|[C:5]-[C&H2&+0&D2:4]-[c:3].[C&H1&+0&D2:2](-[O&H0&+0&D2:1]-C)=O>>[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[O&H1&+0&D1:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[C:12]([F:13])([F:14])[F:15].C[O:16][CH:17]=O>CCOCC.Cl.[Na]>[CH3:1][O:2][C:3](=[O:4])[C:5](=[CH:17][OH:16])[c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[C:12]([F:13])([F:14])[F:15]|US07692005B2_0455
1.3.5|[c:6]:[c&H0&+0&D3:5](:[c:4])-B(-O)-O.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)B(O)O.[cH:9]1[cH:10][n:11][nH:12][cH:13]1>CC([O-])=O.CC([O-])=O.ClCCl.c1ccncc1.[Cu+2]>[O:1]=[CH:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)-[n:12]1[cH:13][cH:9][cH:10][n:11]1|US08822447B2_0547
3.11.31|[C&H3&+0&D1:5]-[N&+:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H2&+0&D2:5](-[N&+:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|O.[CH3:1][N+:2]([O-:3])=[O:4].[O-:5][n+:6]1[cH:7][c:8]([n+:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)[O-:16])[CH:17]=[O:18]>CO.CCN(CC)CC>[O-:3][N+:2](=[O:4])[CH2:1][CH:17]([OH:18])[c:8]1[cH:7][n+:6]([c:15]2[cH:14][cH:13][cH:12][cH:11][c:10]2[n+:9]1[O-:16])[O-:5]|US10774096B2_0370
3.11.2|[C:5]-[C&H2&+0&D2:4]-[C:3].[C&H1&+0&D2:2](-[O&H0&+0&D2:1]-C)=O>>[C:5]/[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]\[O&H1&+0&D1:1]|[CH2:1]=[C:2]1[CH2:3][C@H:4]2[C@@H:5]3[CH2:6][CH2:7][C@:8]([C@:9]3([CH2:10][CH2:11][C@@H:12]2[C@:13]2([CH2:14][CH2:15][C:16]([CH:17]=[C:18]12)=[O:19])[CH3:20])[CH3:21])([CH3:22])[OH:23].C[O:24][CH:25]=O>O.O.[Na+].Cl.C[O-].CCOC(C)=O.c1ccncc1>[CH2:1]=[C:2]1[CH2:3][C@H:4]2[C@@H:5]3[CH2:6][CH2:7][C@:8]([C@:9]3([CH2:10][CH2:11][C@@H:12]2[C@:13]2([CH2:14]/[C:15]([C:16]([CH:17]=[C:18]12)=[O:19])=[CH:25]/[OH:24])[CH3:20])[CH3:21])([CH3:22])[OH:23]|US10105373B2_0835
2.5.7|[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[N:3])-S-C.[N&H2&+0&D1:2]-[O:1]>>[N&H2&+0&D1:5]/[C&H0&+0&D3:4](=[N&H0&+0&D2:2]\[O:1])-[N:3]|[CH3:1][CH2:2][CH2:3][CH2:4][O:5][NH2:6].CS[C:7](=[NH:8])[NH:9][NH2:10]>O.Cl.I.O[Na]>[CH3:1][CH2:2][CH2:3][CH2:4][O:5]/[N:6]=[C:7](\[NH2:8])[NH:9][NH2:10]|
9.5.4|[C&H2&+0&D2:5]1-[O&H0&+0&D2:4]-[c:3]:[c:2]-[C&H1&+0&D3:1]-1-O>>[c&H1&+0&D2:5]1:[o&H0&+0&D2:4]:[c:3]:[c:2]:[c&H1&+0&D2:1]:1|O[CH:1]1[CH2:2][O:3][c:4]2[cH:5][c:6]([c:7]([cH:8][c:9]21)[Cl:10])[N:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1>O.O=C(O[Na])O[Na].O=P(O)(O)O>[Cl:10][c:7]1[cH:8][c:9]2[cH:1][cH:2][o:3][c:4]2[cH:5][c:6]1[N:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1|EP2881397B1_0081
3.11.13|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][CH:3]([CH2:4][CH3:5])[c:6]1[cH:7][c:8]([n:9][n:10]2[c:11]1[n:12][c:13]([c:14]2-[c:15]1[s:16][cH:17][c:18]([c:19]1[CH3:20])Br)[CH3:21])[CH3:22].[CH3:23][n:24]1[n:25][cH:26][n:27][c:28]1Br>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.CCOC(C)=O.C1CCOC1.Cl[Pd]Cl.[Fe+2].[Zn]>[CH3:1][CH2:2][CH:3]([CH2:4][CH3:5])[c:6]1[cH:7][c:8]([n:9][n:10]2[c:11]1[n:12][c:13]([c:14]2-[c:15]1[s:16][cH:17][c:18]([c:19]1[CH3:20])-[c:28]1[n:27][cH:26][n:25][n:24]1[CH3:23])[CH3:21])[CH3:22]|EP3287454B1_0712
3.11.2|[C:5]-[C&H2&+0&D2:4]-[C:3].[C&H1&+0&D2:2](-[O&H0&+0&D2:1]-C)=O>>[C:5]-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[O&H1&+0&D1:1]|[CH3:1][C:2]1[C:3]([CH2:4][CH2:5][C@:6]2([C:7]=1[CH2:8][CH2:9][C@H:10]1[C@@H:11]3[CH2:12][CH2:13][C@@H:14]([C@:15]3([CH2:16][CH2:17][C@@H:18]12)[CH3:19])[OH:20])[CH3:21])=[O:22].C[O:23][CH:24]=O>CC1C(C(C[C@]2(C=1CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@]2(C)O)C)C)=CO)=O.[NaH]>[CH3:1][C:2]1[C:3]([C:4]([CH2:5][C@:6]2([C:7]=1[CH2:8][CH2:9][C@H:10]1[C@@H:11]3[CH2:12][CH2:13][C@@H:14]([C@:15]3([CH2:16][CH2:17][C@@H:18]12)[CH3:19])[OH:20])[CH3:21])=[CH:24][OH:23])=[O:22]|US08859774B2_0558
3.11.13|[c:6]:[c&H0&+0&D3:5](:[s:4])-Br.[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|Br[c:1]1[cH:2][cH:3][c:4]([s:5]1)-[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1.Br[c:12]1[cH:13][cH:14][cH:15][s:16]1>Cl[Ni]1([P](CCC[P]1(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1)Cl.CCOCC.Cl.[Mg]>[cH:9]1[cH:10][cH:11][c:6]([cH:7][cH:8]1)-[c:4]1[cH:3][cH:2][c:1]([s:5]1)-[c:12]1[cH:13][cH:14][cH:15][s:16]1|US20200017633A1_0046
1.3.5|[C:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-B(-O)-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[C:9]([F:10])([F:11])[F:12])[C:13]([F:14])([F:15])[F:16])[N:17]1[CH2:18][CH2:19][C:20]2([CH2:21][CH2:22]1)[C:23]([NH:24][CH2:25][N:26]2[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)=[O:33].OB(O)[c:34]1[cH:35][cH:36][n:37][cH:38][cH:39]1>CCN(CC)CC.CC([O-])=O.CC([O-])=O.ClCCl.[Cu+2]>[O:33]=[C:23]1[N:24]([CH2:25][N:26]([C:20]11[CH2:19][CH2:18][N:17]([CH2:22][CH2:21]1)[C:2](=[O:1])[c:3]1[cH:8][c:7]([cH:6][c:5]([cH:4]1)[C:13]([F:14])([F:15])[F:16])[C:9]([F:10])([F:11])[F:12])[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[c:34]1[cH:35][cH:36][n:37][cH:38][cH:39]1|US20060276464A1_3667
3.9.44|[C:6]-[C&H1&+0&D3:5](-[C:4])-C(=O)-O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|O=C(O)[CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1.[Cl:6][c:7]1[cH:8][cH:9][c:10]([n:11][n:12]1)[Cl:13]>O.O=S(=O)(O)O>[Cl:6][c:7]1[cH:8][c:9]([c:10]([n:11][n:12]1)[Cl:13])[CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1|US20200115362A1_0482
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([n:8][n:9][c:10]([c:11]2[cH:12]1)Br)[CH2:13][c:14]1[c:15]([cH:16][n:17][cH:18][c:19]1[Cl:20])[Cl:21].Br[c:22]1[n:23][cH:24][cH:25][s:26]1>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CC(=O)O[Pd]OC(C)=O.Cc1ccccc1.C1CCOC1.N#N.[NH4+].O.O.[Cl-].[Zn]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([n:8][n:9][c:10]([c:11]2[cH:12]1)-[c:22]1[n:23][cH:24][cH:25][s:26]1)[CH2:13][c:14]1[c:19]([cH:18][n:17][cH:16][c:15]1[Cl:21])[Cl:20]|US10689379B2_0469
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH:4]=[O:5])[c:6]1[cH:7][cH:8][c:9]2[C:10]([N:11]([CH2:12][CH2:13][O:14][c:15]2[cH:16]1)[c:17]1[cH:18][cH:19][cH:20][c:21]([c:22]1[CH:23]=[O:24])Cl)=[O:25].[CH3:26][n:27]1[n:28][c:29]([cH:30][c:31]([c:32]1=[O:33])[NH:34][c:35]1[cH:36][cH:37][c:38]([cH:39][n:40]1)[S:41]([CH3:42])(=[O:43])=[O:44])Cl>CC(C)c1cc(c(c(c1)C(C)C)-c1ccccc1P(C1CCCCC1)C1CCCCC1)C(C)C.C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.CC1(OB(OC1(C)C)B1OC(C(O1)(C)C)(C)C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(=O)O[Pd]OC(C)=O.C1COCCO1.CC([O-])=O.[O-]C([O-])=O.O.[K+].[K+].[K+].[Pd]>[CH3:26][n:27]1[n:28][c:29]([cH:30][c:31]([c:32]1=[O:33])[NH:34][c:35]1[cH:36][cH:37][c:38]([cH:39][n:40]1)[S:41]([CH3:42])(=[O:43])=[O:44])-[c:21]1[cH:20][cH:19][cH:18][c:17]([c:22]1[CH:23]=[O:24])[N:11]1[CH2:12][CH2:13][O:14][c:15]2[cH:16][c:6]([cH:7][cH:8][c:9]2[C:10]1=[O:25])[C:2]([CH3:1])([CH3:3])[CH:4]=[O:5]|US20200165256A1_0421
3.11.13|[c:6]:[c&H0&+0&D3:5](:[s:4])-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[CH:2][c:3]1[cH:4][s:5][c:6]([cH:7]1)Br.Cl[c:8]1[cH:9][n:10][cH:11][cH:12][n:13]1>O=Cc1ccc(cc1F)Br.Brc1ncccn1>[O:1]=[CH:2][c:3]1[cH:4][s:5][c:6]([cH:7]1)-[c:8]1[cH:9][n:10][cH:11][cH:12][n:13]1|US09868742B2_0519
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[O:1]=[CH:2][c:3]1[cH:4][s:5][c:6]([cH:7]1)Br.Br[c:8]1[cH:9][cH:10][cH:11][cH:12][n:13]1>O=Cc1ccc(cc1F)Br.Brc1ncccn1>[O:1]=[CH:2][c:3]1[cH:4][s:5][c:6]([cH:7]1)-[c:8]1[cH:9][cH:10][cH:11][cH:12][n:13]1|US20130023635A1_0049
3.11.13|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([n:8][n:9][c:10]([c:11]2[cH:12]1)Cl)[CH2:13][CH2:14][CH2:15][C:16](=[O:17])[O:18][CH3:19].Br[c:20]1[n:21][cH:22][cH:23][s:24]1>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CC(=O)O[Pd]OC(C)=O.[Zn]>[CH3:19][O:18][C:16](=[O:17])[CH2:15][CH2:14][CH2:13][c:7]1[n:8][n:9][c:10]([c:11]2[cH:12][c:3]([cH:4][cH:5][c:6]12)[O:2][CH3:1])-[c:20]1[n:21][cH:22][cH:23][s:24]1|US20200172541A1_0262
3.9.61|[C:5]-[C&H2&+0&D2:4]-[#30&+].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:5]-[C&H2&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[Br-].[CH3:1][O:2][c:3]1[cH:4][c:5]2[s:6][c:7]([cH:8][c:9]2[cH:10][c:11]1[Cl:12])[C:13](=[O:14])Cl.[CH3:15][CH2:16][O:17][C:18](=[O:19])[CH2:20][CH2:21][Zn+]>O=C(O[Cu])c1cccs1.C1CCOC1>[CH3:15][CH2:16][O:17][C:18](=[O:19])[CH2:20][CH2:21][C:13](=[O:14])[c:7]1[cH:8][c:9]2[cH:10][c:11]([c:3]([cH:4][c:5]2[s:6]1)[O:2][CH3:1])[Cl:12]|US10793557B2_0844
4.1.16|[N&H2&+0&D1:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[C&H1&+0&D2:1](=O)-O>>[n&H0&+0&D2:5]1:[c&H1&+0&D2:1]:[n&H1&+0&D2:2]:[c:3]:[c:4]:1|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH2:8])[N+:9]([O-:10])=[O:11].O=[CH:12]O>[NH4+].Cl.[OH-]>[O-:10][N+:9](=[O:11])[c:5]1[cH:4][cH:3][c:2]2[n:1][cH:12][nH:8][c:7]2[cH:6]1|EP3507289B1_0139
10.1.5|[Br&H0&+0&D1:5]-N1-C(=O)-C-C-C-1=O.[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[Br&H0&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH2:1]1[CH:2]2[CH2:3][CH:4]3[CH2:5][CH:6]([CH2:7][CH:8]1[C:9]3=[C:10]1[CH:11]3[CH2:12][CH:13]4[CH2:14][CH:15]1[CH2:16][CH:17]([CH2:18]3)[CH2:19]4)[CH2:20]2.O=C1CCC(N1[Br:21])=O>ClCCl>[Br:21][C:4]12[CH2:3][CH:2]3[CH2:20][CH:6]([CH2:7][CH:8]([CH2:1]3)[C:9]1=[C:10]1[CH:11]3[CH2:12][CH:13]4[CH2:19][CH:17]([CH2:16][CH:15]1[CH2:14]4)[CH2:18]3)[CH2:5]2|EP0240366A2_0153
3.9.29|[C&H2&+0&D1:5]=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H2&+0&D2:5](-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH2:1]=[O:2].[CH3:3][c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1Br)[F:10]>CC(=O)O.C1CCOC1.[Mg]>[CH3:3][c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[CH2:1][OH:2])[F:10]|US09206184B2_0463
9.1.5|[Br&H0&+0&D1:4]-N1-C(=O)-C-C-C-1=O.[C&H3&D1:3]-[C&H1&+0&D3:2](-[c:1])-O>>[Br&H0&+0&D1:4]-[C&H1&+0&D3:2](-[C&H3&D1:3])-[c:1]|[CH3:1][CH:2](O)[c:3]1[n:4][o:5][c:6]([n:7]1)-[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[Cl:14].O=C1CCC(N1[Br:15])=O>c1ccc(cc1)P(c1ccccc1)c1ccccc1.C1CCOC1>[CH3:1][CH:2]([Br:15])[c:3]1[n:4][o:5][c:6]([n:7]1)-[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[Cl:14]|US09272966B2_0101
4.2.8|[C&H2&+0&D1:5]=[C&H0&+0&D3:4](-[C:3])-[c:2].[O&H1&+0&D1:1]-O>>[C&H2&+0&D2:5]1-[O&H0&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C:3])-[c:2]|[CH2:1]=[C:2]([C:3](=[O:4])[O:5][CH3:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][c:12]1[CH3:13])[O:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[Cl:21].NC(N)=O.O[OH:22]>CO.CC#N.O=C(O[K])O[K].O=S(O[Na])O[Na]>[CH3:6][O:5][C:3](=[O:4])[C:2]1([CH2:1][O:22]1)[c:7]1[cH:8][cH:9][c:10]([cH:11][c:12]1[CH3:13])[O:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[Cl:21]|US20180282282A1_2173
4.1.45|[N&H2&+0&D1:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[C&H1&+0&D2:1](=N)-N>>[n&H0&+0&D2:5]1:[c&H1&+0&D2:1]:[n&H1&+0&D2:2]:[c:3]:[c:4]:1|Cl.[CH3:1][c:2]1[n:3][cH:4][nH:5][c:6]1/[CH:7]=[C:8]1\[C:9]([NH:10][c:11]2[cH:12][cH:13][c:14]([c:15]([c:16]12)[NH2:17])[NH2:18])=[O:19].N=[CH:20]N>CCO>[CH3:1][c:2]1[n:3][cH:4][nH:5][c:6]1/[CH:7]=[C:8]1\[C:9]([NH:10][c:11]2[cH:12][cH:13][c:14]3[nH:18][cH:20][n:17][c:15]3[c:16]12)=[O:19]|US20090286813A1_0189
5.3.9|[C:6]-[O&H1&+0&D1:5].[C:4]-[#14&H0&+0&D4:3](-[C:2])(-[C:1])-Cl>>[C:6]-[O&H0&+0&D2:5]-[#14&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH:1]#[C:2][CH2:3][CH:4]([OH:5])[C:6]([CH3:7])([CH3:8])[CH2:9][CH2:10][CH3:11].[CH3:12][CH2:13][Si:14](Cl)([CH2:15][CH3:16])[CH2:17][CH3:18]>CN(C)C=O.c1c[nH]cn1>[CH:1]#[C:2][CH2:3][CH:4]([O:5][Si:14]([CH2:15][CH3:16])([CH2:17][CH3:18])[CH2:13][CH3:12])[C:6]([CH3:7])([CH3:8])[CH2:9][CH2:10][CH3:11]|EP3390570B1_0154
5.3.3|[C:6]-[#14&H0&+0&D4:5](-[C:4])(-[C:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C:6]-[#14&H0&+0&D4:5](-[C:4])(-[C:3])-[O&H0&+0&D2:2]-[c:1]|[O:1]=[C:2]1[CH2:3][CH2:4][O:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]12)[OH:12].[CH3:13][CH:14]([CH3:15])[Si:16](Cl)([CH:17]([CH3:18])[CH3:19])[CH:20]([CH3:21])[CH3:22]>CN(C)C=O.c1c[nH]cn1.O>[CH3:13][CH:14]([CH3:15])[Si:16]([O:12][c:8]1[cH:9][cH:10][c:11]2[C:2]([CH2:3][CH2:4][O:5][c:6]2[cH:7]1)=[O:1])([CH:17]([CH3:18])[CH3:19])[CH:20]([CH3:21])[CH3:22]|US20200347020A1_0393
3.9.61|[C:5]-[C&H2&+0&D2:4]-[#30]-Br.[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:5]-[C&H2&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[CH2:14][Zn]Br.[O:15]=[C:16](Cl)[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Br:23]>N#C[Cu]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([CH2:14][C:16](=[O:15])[c:17]1[cH:22][cH:21][c:20]([cH:19][cH:18]1)[Br:23])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]|
1.1.1|[C:6]-[N&H1&+0&D2:5]-[C:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-B(-O)-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][CH2:14][NH:15][C:16]([CH2:17]1)=[O:18].OB(O)[CH:19]1[CH2:20][CH2:21]1>CCN(CC)CC.c1ccncc1.C1CCOC1.CC([O-])=O.CC([O-])=O.[Cu+2]>[O:18]=[C:16]1[CH2:17][N:11]([CH2:12][CH2:13][CH2:14][N:15]1[CH:19]1[CH2:20][CH2:21]1)[C:2](=[O:1])[O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|US20200095262A1_0260
1.2.1|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H3&D1:3].[C:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]1=[CH:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[CH:8]([CH3:9])[CH2:10][CH:11]=O.[CH3:12][NH:13][CH3:14]>CCO.[H][H].[O-2].[Pt+2]>[CH3:1][C:2]1=[CH:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[CH:8]([CH3:9])[CH2:10][CH2:11][N:13]([CH3:12])[CH3:14]|US08609656B2_1174
1.6.8|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H3&D1:3].[C:2]-[C&H2&+0&D2:1]-I>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:1]-[C:2]|Cl.[CH3:1][C:2](=[O:3])[N:4]([CH2:5][CH2:6][CH2:7]I)[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[F:14])-[c:15]1[cH:16][c:17]([c:18]2[c:19]([c:20]([cH:21][c:22]([c:23]2[o:24]1)[F:25])[F:26])[NH2:27])=[O:28].[CH3:29][NH:30][CH3:31]>O.CN(C)C=O.O=C(O[K])O[K]>[CH3:1][C:2](=[O:3])[N:4]([CH2:5][CH2:6][CH2:7][N:30]([CH3:29])[CH3:31])[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[F:14])-[c:15]1[cH:16][c:17]([c:18]2[c:19]([c:20]([cH:21][c:22]([c:23]2[o:24]1)[F:25])[F:26])[NH2:27])=[O:28]|EP1310498A2_0248
1.2.1|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H3&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][NH:2][CH3:3].O=[CH:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[OH:11]>O.[H][H].[Pd]>[CH3:1][N:2]([CH3:3])[CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[OH:11]|EP3190888B1_0336
7.6.1|[C&H3&D1:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C&H3&D1:2])-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:3](-[C&H3&D1:2])-[c:1]|[CH3:1][CH:2]=[C:3]([CH3:4])[c:5]1[cH:6][cH:7][c:8]([n:9][cH:10]1)[NH2:11]>CCO.[Pd]>[CH3:1][CH2:2][CH:3]([CH3:4])[c:5]1[cH:6][cH:7][c:8]([n:9][cH:10]1)[NH2:11]|US20050222227A1_0169
3.5.2|[C&H3&D1:5]-[C&H2&+0&D2:4]-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[n:5]1[n:6][cH:7][c:8]([c:9]([c:10]1=[O:11])Cl)[Cl:12].[CH3:13][CH2:14][Mg]Br>O=c1[nH]ncc(c1Cl)Cl.Cc1ccccc1.CCOCC>[CH3:13][CH2:14][c:9]1[c:8]([cH:7][n:6][n:5]([c:10]1=[O:11])[C:2]([CH3:1])([CH3:3])[CH3:4])[Cl:12]|US08709615B2_0143
7.3.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=[N&H0&+0&D2:2]-[N:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[N&H1&+0&D2:2]-[N:1]|[CH3:1][C:2]([CH3:3])=[N:4][NH:5][C:6](=[O:7])[NH:8][CH:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[O:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]21>O.CO.CC(=O)O.[H][H].[O-2].[Pt+2]>[CH3:1][CH:2]([CH3:3])[NH:4][NH:5][C:6](=[O:7])[NH:8][CH:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[O:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]21|EP0902028A1_0061
7.6.1|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=[C&H1&+0&D2:2]-[C:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:2]-[C:1]|[CH3:1][CH:2]([CH:3]=[O:4])[CH2:5][CH:6]=[C:7]([CH3:8])[CH3:9]>[Pd]>[CH3:1][CH:2]([CH:3]=[O:4])[CH2:5][CH2:6][CH:7]([CH3:8])[CH3:9]|EP2935176B1_0200
1.2.9|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H3&D1:3].[C:2]-[C&H2&+0&D2:1]-O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]O.[CH3:13][NH:14][CH3:15]>C=CCCCCCCCCCC.CCCCCCCCCCCCN>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:14]([CH3:13])[CH3:15]|US20200331886A1_0690
3.9.24|[C&H3&D1:5]-[C&H2&+0&D2:4]-[#12]-Cl.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Cl:1][c:2]1[cH:3][n:4]2[n:5][c:6]([cH:7][cH:8][c:9]2[n:10]1)Cl.[CH3:11][CH2:12][Mg]Cl>Cl[Ni]1([P](CCC[P]1(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1)Cl.C1CCOC1>[CH3:11][CH2:12][c:6]1[cH:7][cH:8][c:9]2[n:10][c:2]([cH:3][n:4]2[n:5]1)[Cl:1]|EP3071578B1_0323
1.1.1|[c:6]:[n&H1&+0&D2:5]:[c:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-B(-O)-O>>[c:6]:[n&H0&+0&D3:5](:[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][CH:2]([CH3:3])[N:4]1[CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[C:10](=[O:11])[c:12]1[cH:13][cH:14][c:15]2[nH:16][c:17]([cH:18][c:19]2[cH:20]1)[C:21](=[O:22])[N:23]1[CH2:24][CH2:25][C:26]([CH2:27][CH2:28]1)([F:29])[F:30].OB(O)[CH:31]1[CH2:32][CH2:33]1>CC([O-])=O.CC([O-])=O.ClC(Cl)Cl.c1ccncc1.[Cu+2]>[CH3:1][CH:2]([CH3:3])[N:4]1[CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[C:10](=[O:11])[c:12]1[cH:13][cH:14][c:15]2[c:19]([cH:20]1)[cH:18][c:17]([n:16]2[CH:31]1[CH2:32][CH2:33]1)[C:21](=[O:22])[N:23]1[CH2:24][CH2:25][C:26]([CH2:27][CH2:28]1)([F:29])[F:30]|US08742110B2_1613
1.6.4|[#14:6]-[N&H0&-&D2:5]-[#14:4].[B:3]-[C&H1&+0&D3:2](-[C:1])-Cl>>[#14:6]-[N&H0&+0&D3:5](-[#14:4])-[C&H1&+0&D3:2](-[B:3])-[C:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][CH:5](Cl)[B:6]1[O:7][C:8]([C:9]([O:10]1)([CH3:11])[CH3:12])([CH3:13])[CH3:14].[CH3:15][Si:16]([CH3:17])([CH3:18])[N-:19][Si:20]([CH3:21])([CH3:22])[CH3:23].[Li+]>>[CH3:15][Si:16]([CH3:17])([CH3:18])[N:19]([CH:5]([CH2:4][CH:2]([CH3:1])[CH3:3])[B:6]1[O:7][C:8]([C:9]([O:10]1)([CH3:11])[CH3:12])([CH3:13])[CH3:14])[Si:20]([CH3:21])([CH3:22])[CH3:23]|US10035811B2_0192
2.1.18|[C&H3&D1:5]-[N&H1&+0&D2:4]-[c:3].[O&H0&D1:2]=[C&H1&+0&D2:1]-O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[c:3])-[C&H1&+0&D2:1]=[O&H0&D1:2]|[CH3:1][NH:2][c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[N+:9]([O-:10])=[O:11])[N+:12]([O-:13])=[O:14].[O:15]=[CH:16]O>O.O.CC(=O)OC(C)=O>[CH3:1][N:2]([CH:16]=[O:15])[c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[N+:9]([O-:10])=[O:11])[N+:12]([O-:13])=[O:14]|EP2418203A1_0083
3.5.2|[C&H3&D1:5]-[C&H2&+0&D2:4]-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][Mg]Br.[O-:3][N+:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([n:10][c:11]1Cl)[Cl:12]>CC(C)(C)[O-].I[Cu].C1CCOC1.[Li+]>[CH3:1][CH2:2][c:11]1[n:10][c:9]([n:8][cH:7][c:6]1[N+:4]([O-:3])=[O:5])[Cl:12]|EP3275881A1_0102
2.1.18|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[O&H0&D1:2]=[C&H1&+0&D2:1]-O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H1&+0&D2:1]=[O&H0&D1:2]|[CH3:1][N:2]([CH3:3])[C:4]1([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1)[CH2:10][NH:11][CH3:12].[O:13]=[CH:14]O>>[CH3:12][N:11]([CH:14]=[O:13])[CH2:10][C:4]1([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1)[N:2]([CH3:1])[CH3:3]|US05292760A
1.1.1|[C:6]-[N&H1&+0&D2:5]-[c:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-B(-O)-O>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][C:2]1([C:3]([NH:4][c:5]2[n:6][c:7]([cH:8][cH:9][c:10]21)[Cl:11])=[O:12])[CH3:13].OB(O)[CH:14]1[CH2:15][CH2:16]1>C[Si](C)(C)[N-][Si](C)(C)C.CN(C)c1ccncc1.Cc1ccccc1.CC([O-])=O.CC([O-])=O.[Na+].[Cu+2]>[CH3:1][C:2]1([C:3]([N:4]([c:5]2[n:6][c:7]([cH:8][cH:9][c:10]21)[Cl:11])[CH:14]1[CH2:15][CH2:16]1)=[O:12])[CH3:13]|US20200276206A1_0477
3.9.24|[C&H3&D1:5]-[C&H2&+0&D2:4]-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][CH2:9][c:10]1[cH:11][c:12]([cH:13][s:14]1)Br.[CH3:15][CH2:16][Mg]Br>Cl[Ni]1([P](CCC[P]1(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1)Cl.CCOCC.C1CCOC1.[NH4+].O.[Cl-]>[CH3:15][CH2:16][c:12]1[cH:13][s:14][c:10]([cH:11]1)[CH2:9][O:8][Si:5]([CH3:6])([CH3:7])[C:2]([CH3:1])([CH3:3])[CH3:4]|EP0321175A1_0299
9.7.73|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-O.[N&+:2]=[N&H0&+0&D2:1]-[#11]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH2:6][C:7]2[C:8]=1[CH:9]=[c:10]1[c:11]=2[cH:12][n:13][n:14]1[CH2:15][CH:16]([CH3:17])O.[N-:18]=[N+:19]=[N:20][Na]>CCN(CC)CC.CN(C)C=O.CS(=O)(=O)Cl.ClCCl.Cl[Na]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH2:6][C:7]2[C:8]=1[CH:9]=[c:10]1[c:11]=2[cH:12][n:13][n:14]1[CH2:15][CH:16]([CH3:17])[N:20]=[N+:19]=[N-:18]|US20200299283A1_0465
1.1.1|[c:6]:[n&H1&+0&D2:5]:[n:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-B(-O)-O>>[c:6]:[n&H0&+0&D3:5](:[n:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[n:11]1[n:12][cH:13][cH:14][c:15]1-[c:16]1[cH:17][cH:18][c:19]2[c:20]([n:21][nH:22][c:23]2[cH:24]1)[CH2:25][CH3:26].OB(O)[CH:27]1[CH2:28][CH2:29]1>CCN(CC)CC.c1ccncc1.C1CCOC1.CC([O-])=O.CC([O-])=O.[Cu+2]>[CH3:26][CH2:25][c:20]1[n:21][n:22]([c:23]2[cH:24][c:16]([cH:17][cH:18][c:19]12)-[c:15]1[cH:14][cH:13][n:12][n:11]1-[c:8]1[cH:7][cH:6][c:5]([cH:10][cH:9]1)[S:2]([CH3:1])(=[O:3])=[O:4])[CH:27]1[CH2:28][CH2:29]1|EP3722298A1_0165
9.7.73|[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-O.[N&+:2]=[N&H0&+0&D2:1]-[#11]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[c:3])-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][CH:2](O)[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[Sn:9]([CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1)([CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1)[CH:22]1[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1.[N-:28]=[N+:29]=[N:30][Na]>c1ccncc1.CN(C)C=O.CS(=O)(=O)Cl.O>[CH3:1][CH:2]([N:30]=[N+:29]=[N-:28])[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[Sn:9]([CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1)([CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1)[CH:22]1[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1|US09309216B2_0236
1.2.9|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H3&D1:3].[c:2]-[C&H2&+0&D2:1]-O>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[CH2:9]O)[NH2:10].[CH3:11][NH:12][CH3:13]>O=S(Cl)Cl.ClCCl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[CH2:9][N:12]([CH3:11])[CH3:13])[NH2:10]|EP2964608B1_0629
7.6.1|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[CH:9]=[C:10]([CH3:11])[CH3:12])[O:13][CH3:14])[C:15](=[O:16])[OH:17]>CCOCC>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[CH2:9][CH:10]([CH3:11])[CH3:12])[O:13][CH3:14])[C:15](=[O:16])[OH:17]|US20190337894A1_0223
1.9.8|[C&H1&+0&D1:6]#[C:5].[C:4]-[#50&H0&+0&D4:3](-[C:2])(-[C:1])-Cl>>[C&H0&+0&D2:6](#[C:5])-[#50&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5](Cl)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13].[CH:14]#[C:15][Si:16]([CH3:17])([CH3:18])[CH3:19]>CCCCCC.CCCC[Li].C1CCOC1>[CH3:17][Si:16]([CH3:18])([CH3:19])[C:15]#[C:14][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[CH2:4][CH2:3][CH2:2][CH3:1]|EP0285342A2_0081
3.7.2|[C:5]#[C&H0&+0&D2:4]-[#12]-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:5]#[C&H0&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][C:2]#[C:3][Mg]Br.[O:4]=[CH:5][c:6]1[c:7]([n:8][n:9]2[c:10]([cH:11][cH:12][cH:13][c:14]12)[Cl:15])-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22]>O=C(O)O[Na].C1CCOC1>[CH3:1][C:2]#[C:3][CH:5]([OH:4])[c:6]1[c:14]2[cH:13][cH:12][cH:11][c:10]([n:9]2[n:8][c:7]1-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22])[Cl:15]|US20080258113A1_0086
1.6.2|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H3&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][NH:2][CH3:3].[CH3:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[CH2:14]Br)[C:15]([CH3:16])=[O:17]>ClC(Cl)Cl>[CH3:16][C:15](=[O:17])[c:11]1[cH:10][cH:9][c:8]([c:13]([cH:12]1)[CH2:14][N:2]([CH3:1])[CH3:3])[NH:7][C:5]([CH3:4])=[O:6]|EP3417851B1_0348
1.6.2|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H3&D1:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][NH:2][CH3:3].[O:4]=[C:5]([CH2:6]Br)[CH:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[F:20]>CCO.CCOCC>[CH3:1][N:2]([CH3:3])[CH2:6][C:5](=[O:4])[CH:7]([c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1)[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[F:20]|US20200290953A1_0227
2.1.2|[C&H3&D1:5]-[N&H3&+&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][O:2][c:3]1[c:4]([c:5]([c:6]2[CH2:7][C:8]([CH2:9][c:10]2[c:11]1[O:12][CH3:13])([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][OH:22])[C:23](=[O:24])O)[O:25][CH3:26])[O:27][CH3:28].[CH3:29][NH3+:30].[Cl-]>CCN=C=NCCCN(C)C.On1nnc2ccccc21.CCN(CC)CC.C1CCOC1.O.Cl>[CH3:13][O:12][c:11]1[c:3]([c:4]([c:5]([c:6]2[CH2:7][C:8]([CH2:9][c:10]12)([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][OH:22])[C:23](=[O:24])[NH:30][CH3:29])[O:25][CH3:26])[O:27][CH3:28])[O:2][CH3:1]|EP1115704B1_0296
4.1.47|[N&H2&+0&D1:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[N&H0&+0&D2:1](=O)-O-C>>[n&H0&+0&D2:5]1:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c:3]:[c:4]:1|CO[N:1]=O.[NH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[NH2:9]>CO.O=S(=O)(O)O.O=NO[Na]>[cH:6]1[cH:5][cH:4][c:3]2[n:2][n:1][nH:9][c:8]2[cH:7]1|US20200291016A1_0367
1.6.2|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C:3].[N&H0&D1:2]#[C&H0&+0&D2:1]-Br>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C:3])-[C&H0&+0&D2:1]#[N&H0&D1:2]|[CH3:1][NH:2][CH:3]1[CH2:4][N:5]([N:6]=[C:7]1[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14])[C:15](=[O:16])[NH:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[C:24]([F:25])([F:26])[F:27].[N:28]#[C:29]Br>ClCCl.[Na+].[OH-]>[CH3:1][N:2]([C:29]#[N:28])[CH:3]1[CH2:4][N:5]([N:6]=[C:7]1[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14])[C:15](=[O:16])[NH:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[C:24]([F:25])([F:26])[F:27]|US20200347009A1_0485
2.3.7|[C:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[n:1])-n1:c:n:c:c:1>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[C:7]([NH:8][C:9](=[C:10]([CH:11]1[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18])[C:19](=[O:20])[O:21][CH3:22])[CH3:23])[CH2:24][O:25][CH2:26][CH2:27][NH2:28].[O:29]=[C:30]([n:31]1[cH:32][n:33][cH:34][cH:35]1)n1cncc1>CN1CCOCC1.C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[C:7]([NH:8][C:9](=[C:10]([CH:11]1[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18])[C:19](=[O:20])[O:21][CH3:22])[CH3:23])[CH2:24][O:25][CH2:26][CH2:27][NH:28][C:30](=[O:29])[n:31]1[cH:35][cH:34][n:33][cH:32]1|EP3418276A1_0660
3.7.3|[C:5]-[C&H1&+0&D2:4]=[O&H0&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-[#12]-Cl>>[C:5]-[C&H1&+0&D3:4](-[O&H1&+0&D1:3])-[C&H2&+0&D2:1]-[C:2]|[CH2:1]=[CH:2][CH2:3][Mg]Cl.[CH3:4][CH:5]([CH3:6])[c:7]1[n:8][c:9]([c:10]([n:11]1/[CH:12]=[CH:13]/[CH:14]=[O:15])-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22])-[c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29]>C1CCOC1>[CH2:1]=[CH:2][CH2:3][CH:14]([OH:15])/[CH:13]=[CH:12]/[n:11]1[c:10]([c:9]([n:8][c:7]1[CH:5]([CH3:4])[CH3:6])-[c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29])-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22]|US20040242871A1_0733
3.7.2|[C:5]-[C&H2&+0&D2:4]-[#12]-Br.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][Mg]Br.[O:6]=[CH:7][CH:8]=[CH:9][CH:10]=[CH:11][c:12]1[cH:13][n:14]([c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]12)[CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>O.CCOC(C)=O.C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:7]([OH:6])[CH:8]=[CH:9][CH:10]=[CH:11][c:12]1[cH:13][n:14]([c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21)[CH2:21][c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1|US20050038112A1_0102
3.7.2|[C:5]-[C&H2&+0&D2:4]-[#12]-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][Mg]Br.[O:6]=[C:7]([NH:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[CH:15]=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][n:22]1>O.C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:15]([OH:16])[c:13]1[cH:12][cH:11][cH:10][c:9]([cH:14]1)[NH:8][C:7](=[O:6])[c:17]1[cH:18][cH:19][cH:20][cH:21][n:22]1|EP2251326A1_0976
2.1.27|[C:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-n1:c:n:c:c:1>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][O:2][C:3](=[O:4])n1ccnc1.[NH2:5][CH2:6][C@H:7]1[CH2:8][N:9]([C:10]([O:11]1)=[O:12])[c:13]1[cH:14][cH:15][c:16]([c:17]([cH:18]1)[F:19])[N:20]1[CH2:21][CH2:22][O:23][CH2:24][CH2:25]1>CN(C)c1ccncc1.CN(C)C=O>[CH3:1][O:2][C:3](=[O:4])[NH:5][CH2:6][C@H:7]1[CH2:8][N:9]([C:10]([O:11]1)=[O:12])[c:13]1[cH:14][cH:15][c:16]([c:17]([cH:18]1)[F:19])[N:20]1[CH2:21][CH2:22][O:23][CH2:24][CH2:25]1|US20190225593A1_0450
3.9.23|[C:5]-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[C:2].[C&H2&+0&D2:1](-I)-I>>[C:5]-[C&H1&+0&D3:4]1-[C&H1&+0&D3:3](-[C:2])-[C&H2&+0&D2:1]-1|[CH3:1][C:2]12[CH2:3][CH2:4][CH:5]3[CH2:6][CH:7]2[CH:8]=[CH:9][C:10]1([C:11]3([CH3:12])[CH3:13])[OH:14].I[CH2:15]I>CCCCCCCC=CCO.CCOCC.Cl[Cu].[Zn]>[CH3:1][C:2]12[CH2:3][CH2:4][CH:5]3[CH2:6][CH:7]2[CH:8]2[CH2:15][CH:9]2[C:10]1([C:11]3([CH3:12])[CH3:13])[OH:14]|US05242945A
3.7.3|[O&H0&+0&D1:5]=[C&H1&+0&D2:4]-[c:3].[c:2]-[C&H2&+0&D2:1]-[#12]-Cl>>[O&H1&+0&D1:5]-[C&H1&+0&D3:4](-[c:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[Br:9].Cl[Mg][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O.Cl.CCOCC>[OH:1][CH:2]([CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[Br:9]|EP1007514B1_0060
2.6.7|[C:5]-[O&H1&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-n1:c:n:c:c:1>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[P:8](=[N:9][C:10](=[O:11])n1ccnc1)([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[OH:24][CH2:25][c:26]1[cH:27][cH:28][cH:29][n:30][cH:31]1>COCCOC.[NaH]>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[P:8](=[N:9][C:10](=[O:11])[O:24][CH2:25][c:26]1[cH:31][n:30][cH:29][cH:28][cH:27]1)([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20070142638A1_0440
3.9.77|[C&H3&+0&D1:5]-[#3].[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[O&H1&+0&D1:4])(-[c:2])-[c:1]|[CH3:1][Li].[O:2]=[C:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[Br:16]>>[CH3:1][C:3]([OH:2])([c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[Br:16])[c:4]1[cH:9][cH:8][cH:7][cH:6][cH:5]1|US09683003B2_0982
2.6.6|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[n:1])-n1:c:n:c:c:1>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[n:1]|[CH3:1][O:2][N:3]=[C:4]([C:5](=[O:6])[NH:7][CH:8]1[C:9]([N:10]2[C@@H:11]1[S:12][CH2:13][C:14](=[C:15]2[C:16](=[O:17])[O:18][CH:19]([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[CH2:32][OH:33])=[O:34])[c:35]1[cH:36][s:37][c:38]([n:39]1)[NH:40][CH:41]=[O:42].[O:43]=[C:44](n1ccnc1)[n:45]1[cH:46][cH:47][n:48][cH:49]1>C1CCOC1>[CH3:1][O:2][N:3]=[C:4]([C:5](=[O:6])[NH:7][CH:8]1[C:9]([N:10]2[C@@H:11]1[S:12][CH2:13][C:14](=[C:15]2[C:16](=[O:17])[O:18][CH:19]([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[CH2:32][O:33][C:44](=[O:43])[n:45]1[cH:46][cH:47][n:48][cH:49]1)=[O:34])[c:35]1[cH:36][s:37][c:38]([n:39]1)[NH:40][CH:41]=[O:42]|US20200331908A1_0193
2.1.2|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H3&+&D1:2]-[O&H1&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[O&H1&D1:1])=[O&H0&D1:3]|[Cl-].[CH3:1][CH:2]([CH3:3])[CH2:4][CH2:5][N:6]([CH2:7][CH:8]([CH2:9][S:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])O)[C:19](=[O:20])[NH:21][C@@H:22]([CH2:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[C:30](=[O:31])[NH:32][CH3:33].[NH3+:34][OH:35]>Cl.CCN=C=NCCCN(C)C.CN(C)C=O.CN1CCOCC1.O=C(O)CC(O)(CC(=O)O)C(=O)O.On1nnc2c1cccc2.ClCCl>[CH3:1][CH:2]([CH3:3])[CH2:4][CH2:5][N:6]([CH2:7][CH:8]([CH2:9][S:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[NH:34][OH:35])[C:19](=[O:20])[NH:21][C@@H:22]([CH2:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[C:30](=[O:31])[NH:32][CH3:33]|EP0798291A1_0077
1.6.4|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H3&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][NH:2][CH3:3].Cl[CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11]>O.CCOCC.C1CCOC1>[CH3:1][N:2]([CH3:3])[CH2:4][c:5]1[cH:10][cH:9][c:8]([cH:7][cH:6]1)[Cl:11]|US20200071301A1_1376
2.1.27|[C:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-n1:c:n:c:c:1>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH2:2][CH2:3][N:4]([CH2:5][CH2:6][NH2:7])[CH2:8][CH2:9][NH2:10].[NH2:11][c:12]1[n:13][c:14]([c:15]([n:16][c:17]1[Cl:18])[C:19](=[O:20])n1ccnc1)[NH2:21]>C1CCOC1>[CH3:1][CH2:2][CH2:3][N:4]([CH2:5][CH2:6][NH2:7])[CH2:8][CH2:9][NH:10][C:19](=[O:20])[c:15]1[n:16][c:17]([c:12]([n:13][c:14]1[NH2:21])[NH2:11])[Cl:18]|US20190315757A1_1504
4.2.20|[O&H1&+0&D1:5]-[c:4]:[c:3]-[O&H1&+0&D1:2].[C&H2&+0&D2:1](-Br)-Br>>[O&H0&+0&D2:5]1-[C&H2&+0&D2:1]-[O&H0&+0&D2:2]-[c:3]:[c:4]-1|[O:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[OH:9])[OH:10].Br[CH2:11]Br>CN(C)C=O.F[K].F[Cs]>[O:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]2[O:10][CH2:11][O:9][c:7]2[cH:8]1|US20110009429A1_0126
2.6.7|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-n1:c:n:c:c:1>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2]([c:3]1[n:4][cH:5][n:6]2[c:7]1[C@@H:8]1[CH2:9][CH2:10][CH2:11][N:12]1[C:13]([c:14]1[c:15]([cH:16][cH:17][cH:18][c:19]1-2)[Cl:20])=[O:21])n1ccnc1.[OH:22][CH:23]1[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]1>O.CN(C)C=O.[NaH]>[O:21]=[C:13]1[c:14]2[c:15]([cH:16][cH:17][cH:18][c:19]2-[n:6]2[cH:5][n:4][c:3]([c:7]2[C@@H:8]2[CH2:9][CH2:10][CH2:11][N:12]12)[C:2](=[O:1])[O:22][CH:23]1[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]1)[Cl:20]|US20040147561A1_0972
3.9.77|[C&H3&+0&D1:5]-[#3].[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH:8]1[C:9]([CH2:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[O:22].[CH3:23][Li]>O.CCOCC>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH:8]1[N:13]([CH2:12][CH2:11][CH2:10][C:9]1([CH3:23])[OH:22])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]|EP1288220A2_0106
2.6.6|[O&H0&D1:5]=[C&H0&+0&D3:4](-[n:3])-n1:c:n:c:c:1.[O&H1&+0&D1:2]-[c:1]>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[n:3]|[CH3:1][C:2]1([CH2:3][c:4]2[cH:5][cH:6][cH:7][c:8]([c:9]2[O:10]1)[OH:11])[CH3:12].[O:13]=[C:14](n1ccnc1)[n:15]1[cH:16][cH:17][n:18][cH:19]1>>[CH3:1][C:2]1([CH2:3][c:4]2[cH:5][cH:6][cH:7][c:8]([c:9]2[O:10]1)[O:11][C:14](=[O:13])[n:15]1[cH:16][cH:17][n:18][cH:19]1)[CH3:12]|US20090131502A1_0601
3.9.23|[C:5]-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[c:2].[C&H2&+0&D2:1](-I)-I>>[C:5]-[C&H1&+0&D3:4]1-[C&H1&+0&D3:3](-[c:2])-[C&H2&+0&D2:1]-1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([o:8][c:9]2[cH:10][c:11]3[c:12]([CH:13]=[CH:14][CH2:15][CH2:16][N:17]3[S:18]([CH3:19])(=[O:20])=[O:21])[cH:22][c:23]21)-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30].I[CH2:31]I>CC[Zn]CC.O=C(O)C(F)(F)F.ClCCl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([o:8][c:9]2[cH:10][c:11]3[c:12]([cH:22][c:23]12)[CH:13]1[CH2:31][CH:14]1[CH2:15][CH2:16][N:17]3[S:18]([CH3:19])(=[O:20])=[O:21])-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30]|US09273083B2_0275
4.2.20|[O&H1&+0&D1:5]-[c:4]:[c:3]-[O&H1&+0&D1:2].[C&H2&+0&D2:1](-Cl)-Cl>>[O&H0&+0&D2:5]1-[C&H2&+0&D2:1]-[O&H0&+0&D2:2]-[c:3]:[c:4]-1|[OH:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[OH:8].Cl[CH2:9]Cl>CS(C)=O.O[Na]>[cH:4]1[cH:5][cH:6][c:7]2[O:8][CH2:9][O:1][c:2]2[cH:3]1|US20190135825A1_0627
1.6.4|[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H3&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:5]-[N&H0&+0&D3:4](-[C&H3&D1:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][NH:2][CH3:3].[O-:4][n+:5]1[c:6]2[c:7]([cH:8][cH:9][cH:10][c:11]2[n+:12]([c:13]2[c:14]([cH:15][cH:16][cH:17][c:18]21)[OH:19])[O-:20])[O:21][CH2:22][CH2:23][CH2:24]Cl>CC(C)=O.O=C=O>[CH3:1][N:2]([CH3:3])[CH2:24][CH2:23][CH2:22][O:21][c:7]1[cH:8][cH:9][cH:10][c:11]2[c:6]1[n+:5]([c:18]1[cH:17][cH:16][cH:15][c:14]([c:13]1[n+:12]2[O-:20])[OH:19])[O-:4]|US20200331850A1_0743
2.1.2|[C&H3&D1:5]-[N&H3&+&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][NH:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH2:12][NH:13][C:14](=[O:15])[c:16]1[cH:17][c:18]([cH:19][c:20]2[c:21]1[cH:22][n:23][n:24]2-[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[F:31])[C:32](=[O:33])O.[CH3:34][NH3+:35].[Cl-]>c1ccc2nnn(c2c1)O[P+](N1CCCC1)(N1CCCC1)N1CCCC1.CCN(CC)CC.F[P-](F)(F)(F)(F)F.CN(C)C=O>[CH3:34][NH:35][C:32](=[O:33])[c:18]1[cH:19][c:20]2[c:21]([cH:22][n:23][n:24]2-[c:25]2[cH:26][cH:27][c:28]([cH:29][cH:30]2)[F:31])[c:16]([cH:17]1)[C:14](=[O:15])[NH:13][CH2:12][c:9]1[cH:8][cH:7][c:6]([cH:11][cH:10]1)[S:3](=[O:4])(=[O:5])[NH:2][CH3:1]|US20120149682A1_0407
2.6.7|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-n1:c:n:c:c:1.[C:2]-[O&H1&+0&D1:1]>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])([OH:4])[C:5](=[O:6])[OH:7].[CH3:8][C:9]1([CH2:10][c:11]2[cH:12][c:13]([c:14]([c:15]([c:16]2[C:17]1=[O:18])[Cl:19])[Cl:20])[O:21][CH2:22][CH2:23][CH2:24][C:25](=[O:26])n1ccnc1)[CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1>[NaH]>[CH3:1][C:2]([CH3:3])([O:4][C:25](=[O:26])[CH2:24][CH2:23][CH2:22][O:21][c:13]1[cH:12][c:11]2[CH2:10][C:9]([C:17]([c:16]2[c:15]([c:14]1[Cl:20])[Cl:19])=[O:18])([CH3:8])[CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1)[C:5](=[O:6])[OH:7]|US08101615B2_0659
3.7.3|[C:5]-[C&H2&+0&D2:4]-[#12]-Cl.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH:10]=[O:11].[CH3:12][O:13][C:14]([CH3:15])([CH3:16])[CH2:17][CH2:18][CH2:19][CH:20]([CH3:21])[CH2:22][CH2:23][Mg]Cl>Cl.C1CCOC1>[CH3:12][O:13][C:14]([CH3:15])([CH3:16])[CH2:17][CH2:18][CH2:19][CH:20]([CH3:21])[CH2:22][CH2:23][CH:10]([OH:11])[c:7]1[cH:8][cH:9][c:4]([cH:5][cH:6]1)[CH:2]([CH3:1])[CH3:3]|EP3753932A1_0317
2.1.27|[C:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-n1:c:n:c:c:1>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][CH2:2][NH2:3].[CH3:4][CH:5]([CH3:6])[NH:7][c:8]1[n:9][c:10]([c:11]([n:12][c:13]1[Cl:14])[C:15](=[O:16])[N:17]=[CH:18][NH:19][NH:20][C:21](=[O:22])n1ccnc1)[NH2:23]>CN1CCCC1=O>[CH3:1][CH2:2][NH:3][C:21](=[O:22])[NH:20][NH:19][CH:18]=[N:17][C:15](=[O:16])[c:11]1[n:12][c:13]([c:8]([n:9][c:10]1[NH2:23])[NH:7][CH:5]([CH3:4])[CH3:6])[Cl:14]|US20190345161A1_0408
7.4.2|[C:5]-[C&H1&+0&D3:4](-[N:3])-[C&H0&+0&D3:2](=[O&H0&+0&D1:1])-O-C>>[C:5]-[C@&H1&+0&D3:4](-[N:3])-[C&H2&+0&D2:2]-[O&H1&+0&D1:1]|CO[C:1](=[O:2])[CH:3]1[CH2:4][CH2:5][C:6]([NH:7]1)=[O:8]>[Na+].CO.[BH4-]>[O:8]=[C:6]1[CH2:5][CH2:4][C@H:3]([NH:7]1)[CH2:1][OH:2]|US20200325118A1_0479
3.9.23|[C:5]-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[N:2].[C&H2&+0&D2:1](-I)-I>>[C:5]-[C&H1&+0&D3:4]1-[C&H1&+0&D3:3](-[N:2])-[C&H2&+0&D2:1]-1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C@H:6]1[CH2:7][CH:8]=[CH:9][N:10]1[C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17].I[CH2:18]I>Cc1ccccc1.CC[Zn]CC>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C@H:6]1[CH2:7][CH:8]2[CH2:18][CH:9]2[N:10]1[C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17]|US09066944B2_0355
2.6.7|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-n1:c:n:c:c:1>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][OH:8].[CH3:9][O:10][c:11]1[cH:12][c:13]([c:14]([cH:15][c:16]1[O:17][CH3:18])[C:19](=[O:20])[c:21]1[n:22][n:23]([n:24][c:25]1[C:26](=[O:27])[O:28][CH2:29][CH3:30])[CH:31]([O:32][C:33](=[O:34])n1ccnc1)[CH:35]([CH3:36])[CH3:37])[N+:38]([O-:39])=[O:40]>O=C(O)C(F)(F)F>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:8][C:33](=[O:34])[O:32][CH:31]([CH:35]([CH3:36])[CH3:37])[n:23]1[n:24][c:25]([c:21]([n:22]1)[C:19](=[O:20])[c:14]1[cH:15][c:16]([c:11]([cH:12][c:13]1[N+:38]([O-:39])=[O:40])[O:10][CH3:9])[O:17][CH3:18])[C:26](=[O:27])[O:28][CH2:29][CH3:30]|EP3108519B1_0268
3.9.77|[C&H3&+0&D1:5]-[#3].[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][CH:2]1[C:3]([c:4]2[s:5][cH:6][cH:7][c:8]2[C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)=[C:16]1[CH2:17][CH2:18][N:19]([CH2:20][CH2:21]1)[CH3:22])=[O:23].[CH3:24][Li]>c1ccccc1.CCOCC.[NH4+].[Cl-]>[CH3:22][N:19]1[CH2:18][CH2:17][C:16]([CH2:21][CH2:20]1)=[C:9]1[c:8]2[cH:7][cH:6][s:5][c:4]2[C:3]([CH:2]([c:15]2[cH:14][cH:13][cH:12][cH:11][c:10]12)[CH3:1])([CH3:24])[OH:23]|US09353063B2_0415
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=O.[N&H2&+0&D1:2]-[O:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=[N&H0&+0&D2:2]-[O:1]|Cl.[ClH:1].[CH3:2][NH:3][CH2:4][CH:5]([F:6])[CH2:7][O:8][NH2:9].[CH3:10][C:11]([CH3:12])=O>CCO.O[Na]>[ClH:1].[CH3:2][NH:3][CH2:4][CH:5]([F:6])[CH2:7][O:8][N:9]=[C:11]([CH3:10])[CH3:12]|US20080114019A1_1202
3.5.3|[C:6]-[C&H1&+0&D3:5](-[C:4])-[#30&+].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[OH:9])[CH2:10][C:11](=[O:12])[NH:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)I.[CH2:20]1[CH2:21][CH2:22][CH:23]([CH2:24][CH2:25]1)[Zn+].[Br-]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.C1CCOC1.[NH4+].[Cl-].[Pd]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[OH:9])[CH2:10][C:11](=[O:12])[NH:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[CH:23]1[CH2:24][CH2:25][CH2:20][CH2:21][CH2:22]1|US20040248983A1_0296
2.1.2|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[CH3:1][C:2](=[O:3])O.[NH2:4][CH2:5][CH:6]=[C:7]([c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)-[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>CC(=O)OC(C)=O>[CH3:1][C:2](=[O:3])[NH:4][CH2:5][CH:6]=[C:7]([c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)-[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|EP3225618B1_0843
8.2.1|[N&H2&D1:4]-[S&H0&+0&D2:3]-[c:2].[O&H1&+0&D1:1]-O-C(=O)-c1:c:c:c:c(-Cl):c:1>>[N&H2&D1:4]-[S&H0&+0&D3:3](=[O&H0&+0&D1:1])-[c:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[n:10][s:11][c:12]([n:13]1)[S:14][NH2:15].O=C(O[OH:16])c1cccc(c1)Cl>O.CO.COCCOC.CCOC(C)=O.O=C(O)O[Na].ClCCl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[n:10][s:11][c:12]([n:13]1)[S:14]([NH2:15])=[O:16]|EP0353268B1_0070
2.1.2|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[O&H1&D1:1])=[O&H0&D1:3]|Cl.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([s:7]1)[S:8][CH2:9][C:10](=[O:11])O.[NH2:12][OH:13]>[Na+].CCO.CC[O-].[Na]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([s:7]1)[S:8][CH2:9][C:10](=[O:11])[NH:12][OH:13]|US04307094A
1.8.15|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-I.[S&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])I.[SH:4][c:5]1[cH:6][cH:7][n:8][cH:9][cH:10]1>CCO>[CH3:1][CH:2]([CH3:3])[S:4][c:5]1[cH:6][cH:7][n:8][cH:9][cH:10]1|US20100016383A1_0217
2.6.8|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:1]-[N:2]|[CH3:1][C:2](=[O:3])O.[CH3:4][C:5]([CH3:6])([c:7]1[cH:8][c:9]([cH:10][c:11]([cH:12]1)[Cl:13])[Cl:14])[N:15]1[CH2:16][O:17][C:18](=[C:19]([C:20]1=[O:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[CH:28]=[N:29][OH:30]>O>[CH3:4][C:5]([CH3:6])([c:7]1[cH:8][c:9]([cH:10][c:11]([cH:12]1)[Cl:13])[Cl:14])[N:15]1[CH2:16][O:17][C:18](=[C:19]([C:20]1=[O:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[CH:28]=[N:29][O:30][C:2]([CH3:1])=[O:3]|EP2943495B1_1016
2.1.3|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[N&H2&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N&H2&D1:1])=[O&H0&D1:3]|[CH3:1][S:2][CH2:3][CH2:4][C@H:5]([NH:6][C:7](=[O:8])[C@H:9]([CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[NH:17][C:18](=[O:19])[CH2:20][NH:21][C:22](=[O:23])[CH2:24][NH:25][C:26](=[O:27])[C@H:28]([CH2:29][c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[OH:36])[NH:37][C:38](=[O:39])[O:40][CH2:41][c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1)[C:48](=[O:49])[NH:50][C@H:51]([C:52](=[O:53])[NH:54][C@@H:55]([CH2:56][O:57][CH2:58][c:59]1[cH:60][cH:61][cH:62][cH:63][cH:64]1)[C:65](=[O:66])[NH:67][C@@H:68]([CH2:69][CH2:70][C:71](=[O:72])[O:73][CH2:74][c:75]1[cH:76][cH:77][cH:78][cH:79][cH:80]1)[C:81](=[O:82])[NH:83][C@@H:84]([CH2:85][CH2:86][CH2:87][CH2:88][NH:89][C:90](=[O:91])[O:92][CH2:93][c:94]1[cH:95][cH:96][cH:97][cH:98][cH:99]1)[C:100](=[O:101])O)[C@@H:102]([CH3:103])[O:104][CH2:105][c:106]1[cH:107][cH:108][cH:109][cH:110][cH:111]1.[NH2:112][NH2:113]>O.CN(C)C=O.CN1CCOCC1.On1nnc2c1cccc2.C(=NC1CCCCC1)=NC1CCCCC1>[CH3:1][S:2][CH2:3][CH2:4][C@H:5]([NH:6][C:7](=[O:8])[C@H:9]([CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[NH:17][C:18](=[O:19])[CH2:20][NH:21][C:22](=[O:23])[CH2:24][NH:25][C:26](=[O:27])[C@H:28]([CH2:29][c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[OH:36])[NH:37][C:38](=[O:39])[O:40][CH2:41][c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1)[C:48](=[O:49])[NH:50][C@H:51]([C:52](=[O:53])[NH:54][C@@H:55]([CH2:56][O:57][CH2:58][c:59]1[cH:60][cH:61][cH:62][cH:63][cH:64]1)[C:65](=[O:66])[NH:67][C@@H:68]([CH2:69][CH2:70][C:71](=[O:72])[O:73][CH2:74][c:75]1[cH:76][cH:77][cH:78][cH:79][cH:80]1)[C:81](=[O:82])[NH:83][C@@H:84]([CH2:85][CH2:86][CH2:87][CH2:88][NH:89][C:90](=[O:91])[O:92][CH2:93][c:94]1[cH:95][cH:96][cH:97][cH:98][cH:99]1)[C:100](=[O:101])[NH:112][NH2:113])[C@@H:102]([CH3:103])[O:104][CH2:105][c:106]1[cH:107][cH:108][cH:109][cH:110][cH:111]1|US20200017466A1_0532
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[N&H2&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[N&H2&D1:1])-[c:3]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH:16]([CH2:17][CH2:18]1)[c:19]1[n:20][o:21][c:22]2[cH:23][c:24]([cH:25][cH:26][c:27]21)[F:28])[C:29]([CH3:30])=O.[NH2:31][NH2:32]>CCO>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH:16]([CH2:17][CH2:18]1)[c:19]1[n:20][o:21][c:22]2[cH:23][c:24]([cH:25][cH:26][c:27]21)[F:28])[C:29]([CH3:30])=[N:31][NH2:32]|US20060105458A1_0069
2.6.8|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])O.[CH3:4][C:5]1([NH:6][C:7]2([CH2:8][CH2:9][CH:10]1[CH:11]([CH2:12]2)[OH:13])[CH3:14])[CH3:15]>CC(=O)OC(C)=O>[CH3:1][C:2](=[O:3])[O:13][CH:11]1[CH2:12][C:7]2([CH2:8][CH2:9][CH:10]1[C:5]([NH:6]2)([CH3:4])[CH3:15])[CH3:14]|US04311852A
2.1.3|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[N:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N:1])=[O&H0&D1:3]|[CH3:1][C:2](=[O:3])O.[NH2:4][NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N+:12]([O-:13])=[O:14]>>[CH3:1][C:2](=[O:3])[NH:4][NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N+:12]([O-:13])=[O:14]|EP2516433B1_0889
2.6.8|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][C:2](=[O:3])O.[O:4]=[C:5]1[NH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[C:13]1([c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[OH:20])[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[O:27][S:28](=[O:29])(=[O:30])[OH:31].[Na:32]>[Na+].CC([O-])=O>[CH3:1][C:2](=[O:3])[O:20][c:17]1[cH:16][cH:15][c:14]([cH:19][cH:18]1)[C:13]1([C:5]([NH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21)=[O:4])[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[O:27][S:28](=[O:29])(=[O:30])[OH:31].[Na:32]|EP2890305B1_0065
9.7.92|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[O&H1&D1:1]|Cl.[CH3:1][C:2](=O)[CH2:3][c:4]1[cH:5][n:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]12)-[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[Cl:19].[NH2:20][OH:21]>O.[Na+].CCO.CC([O-])=O>[CH3:1][C:2]([CH2:3][c:4]1[cH:5][n:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21)-[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[Cl:19])=[N:20][OH:21]|US20200299611A1_0102
2.1.5|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[S:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[S:1])=[O&H0&D1:3]|[CH3:1][C@@:2]([OH:3])([C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([cH:11][c:12]1[Cl:13])[S:14]([NH2:15])(=[O:16])=[O:17])[C:18]([F:19])([F:20])[F:21].[CH3:22][C:23](=[O:24])O>CCN=C=NCCCN(C)C.CN(C)c1ccncc1.ClCCl.O[Li].O.Cl>[CH3:1][C@@:2]([OH:3])([C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([cH:11][c:12]1[Cl:13])[S:14](=[O:16])(=[O:17])[NH:15][C:23]([CH3:22])=[O:24])[C:18]([F:19])([F:20])[F:21]|US20100256092A1_0898
2.1.2|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[CH3:1][C:2](=[O:3])O.[NH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1>[PH4+]>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1|EP3018125B1_0409
2.1.2|[C&H3&D1:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][NH2:2].[O:3]=[C:4](O)[C@H:5]1[CH2:6][CH2:7][C@H:8]([N:9]1[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[OH:19]>CC(=O)OC(C)=O>[CH3:1][NH:2][C:4](=[O:3])[C@@H:5]1[CH2:6][CH2:7][C@@H:8]([N:9]1[CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[OH:19]|US07560569B2_0215
1.2.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])=O.[CH3:4][N:5]1[CH2:6][CH2:7][CH2:8][CH2:9][CH:10]1[CH2:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[NH2:19]>CCO.CC(=O)O.[H][H].[O-2].[Pt+2]>[CH3:4][N:5]1[CH2:6][CH2:7][CH2:8][CH2:9][CH:10]1[CH2:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[NH:19][CH:2]([CH3:1])[CH3:3]|US20200354345A1_1100
1.7.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-I.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])I.[CH3:4][N:5]([CH3:6])[S:7](=[O:8])(=[O:9])[c:10]1[cH:11][cH:12][cH:13][c:14]2[NH:15][c:16]3[cH:17][c:18]([cH:19][cH:20][c:21]3[S:22][c:23]12)[OH:24]>>[CH3:4][N:5]([CH3:6])[S:7](=[O:8])(=[O:9])[c:10]1[cH:11][cH:12][cH:13][c:14]2[NH:15][c:16]3[cH:17][c:18]([cH:19][cH:20][c:21]3[S:22][c:23]21)[O:24][CH:2]([CH3:1])[CH3:3]|EP3251679B1_0383
1.7.7|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-O.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][c:2]1[c:3]([c:4]([c:5]([c:6]2[O:7][CH:8]([CH2:9][c:10]12)[CH2:11][C:12](=[O:13])[O:14][CH3:15])[CH3:16])[CH3:17])[OH:18].[CH3:19][CH:20]([CH3:21])O>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CC(C)OC(=O)N=NC(=O)OC(C)C.ClCCl>[CH3:16][c:5]1[c:6]2[O:7][CH:8]([CH2:9][c:10]2[c:2]([c:3]([c:4]1[CH3:17])[O:18][CH:20]([CH3:19])[CH3:21])[CH3:1])[CH2:11][C:12](=[O:13])[O:14][CH3:15]|US20090209522A1_0277
2.6.2|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-I.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH:1]#[C:2][CH2:3][O:4][C:5]([CH3:6])([CH3:7])[CH2:8][CH2:9][CH2:10][CH:11]([CH3:12])[CH2:13][CH:14]=[CH:15][C:16]([CH3:17])=[CH:18][C:19](=[O:20])[OH:21].[CH3:22][CH:23]([CH3:24])I>O.O.CCC(C)=O.O=C(O[K])O[K]>[CH:1]#[C:2][CH2:3][O:4][C:5]([CH3:6])([CH3:7])[CH2:8][CH2:9][CH2:10][CH:11]([CH3:12])[CH2:13][CH:14]=[CH:15][C:16]([CH3:17])=[CH:18][C:19](=[O:20])[O:21][CH:23]([CH3:22])[CH3:24]|US20200113879A1_0433
1.2.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[N&H1&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])=O.[NH2:4][CH2:5][CH2:6][CH2:7][CH:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[CH:15]=[CH:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]21>[H][H].[O-2].[Pt+2]>[CH3:1][CH:2]([CH3:3])[NH:4][CH2:5][CH2:6][CH2:7][CH:8]1[c:22]2[cH:21][cH:20][cH:19][cH:18][c:17]2[CH:16]=[CH:15][c:14]2[cH:13][cH:12][cH:11][cH:10][c:9]21|EP2678329B1_0358
2.1.2|[C&H3&D1:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][NH2:2].[O:3]=[C:4](O)[c:5]1[cH:6][cH:7][c:8]([cH:9][n:10]1)[CH2:11][CH2:12][CH:13]([Br:14])[CH2:15][Br:16]>O=S(Cl)Cl.ClC(Cl)Cl>[CH3:1][NH:2][C:4](=[O:3])[c:5]1[cH:6][cH:7][c:8]([cH:9][n:10]1)[CH2:11][CH2:12][CH:13]([Br:14])[CH2:15][Br:16]|US10836770B2_0387
1.6.8|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-I.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])I.[NH2:4][c:5]1[cH:6][c:7]2[O:8][CH2:9][O:10][c:11]2[cH:12][c:13]1[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>O=C(O[K])O[K]>[CH3:1][CH:2]([CH3:3])[NH:4][c:5]1[cH:6][c:7]2[O:8][CH2:9][O:10][c:11]2[cH:12][c:13]1[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20200339559A1_0676
2.6.3|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-O.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[O&H0&+0&D2:1]-[C:2]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[SH:10].[CH3:11][CH:12]([CH3:13])O>c1ccccc1.O=S(=O)(O)O>[CH3:11][CH:12]([CH3:13])[O:3][C:2](=[O:1])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[SH:10]|US20090105234A1_0106
8.4.3|[C&H3&D1:5]-[N&H0&+0&D3:4](-[C&H3&D1:3])-[C:2].[O&H1&+0&D1:1]-O>>[C&H3&D1:5]-[N&H0&+&D4:4](-[C&H3&D1:3])(-[C:2])-[O&H0&-&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]([CH3:9])[CH3:10].[OH:11]O>>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N+:8]([CH3:9])([CH3:10])[O-:11]|US08530468B2_1213
1.7.6|[C&H3&D1:5]-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][OH:2].[O:3]=[C:4](O)[CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9][NH:10]1>[Na+].CCOCC.C[O-].O=S(Cl)Cl>[CH3:1][O:2][C:4](=[O:3])[CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9][NH:10]1|US09415043B2_0342
1.2.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[C&H3&D1:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:1]-[C&H3&D1:2])-[c:3]|[CH2:1]=[CH:2][CH2:3][c:4]1[cH:5][c:6]([cH:7][c:8]([c:9]1[OH:10])[C:11]([CH3:12])=O)-[c:13]1[cH:14][c:15]([cH:16][c:17]([c:18]1[OH:19])[CH2:20][CH:21]=[CH2:22])[CH2:23][CH3:24].[CH3:25][NH2:26]>O.[Na+].Cl.CO.O=C(O)O[Na].[BH4-]>[CH2:22]=[CH:21][CH2:20][c:17]1[cH:16][c:15]([cH:14][c:13]([c:18]1[OH:19])-[c:6]1[cH:5][c:4]([c:9]([c:8]([cH:7]1)[CH:11]([CH3:12])[NH:26][CH3:25])[OH:10])[CH2:3][CH:2]=[CH2:1])[CH2:23][CH3:24]|US20080275085A1_0862
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[N&H2&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[N&H2&D1:1]|O.[CH3:1][O:2][N:3]=[C:4]([C:5]([CH3:6])=O)[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.[NH2:13][NH2:14]>CCO>[CH3:1][O:2][N:3]=[C:4]([C:5]([CH3:6])=[N:13][NH2:14])[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1|US20190177291A1_0120
9.7.92|[C&H3&D1:5]-[C&H0&+0&D3:4](-[c:3])=O.[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[O&H1&D1:1])-[c:3]|Cl.[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]([F:10])([F:11])[C:12]([F:13])([F:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[NH2:21][OH:22]>CCO.c1ccncc1>[CH3:1][C:2](=[N:21][OH:22])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]([F:10])([F:11])[C:12]([F:13])([F:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20120328569A1_0864
1.2.6|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=O.[N&H2&+0&D1:2]-[N:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=[N&H0&+0&D2:2]-[N:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][c:9]([c:10]2[n:11][n:12][n:13]([c:14]12)[CH2:15][CH3:16])[NH:17][NH2:18])[CH3:19].[CH3:20][C:21]([CH3:22])=O>CC(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][c:9]([c:10]2[n:11][n:12][n:13]([c:14]12)[CH2:15][CH3:16])[NH:17][N:18]=[C:21]([CH3:20])[CH3:22])[CH3:19]|EP2877457B1_0264
1.7.6|[C&H3&D1:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][OH:2].[O:3]=[C:4](O)[c:5]1[cH:6][cH:7][cH:8][c:9]([c:10]1[OH:11])-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>>[CH3:1][O:2][C:4](=[O:3])[c:5]1[cH:6][cH:7][cH:8][c:9]([c:10]1[OH:11])-[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US20190374526A1_0340
1.2.5|[C&H3&D1:5]-[C&H0&+0&D3:4](-[C:3])=O.[C&H3&D1:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:1]-[C&H3&D1:2]|[CH3:1][NH2:2].[CH3:3][C:4](=O)[CH2:5][CH2:6][n:7]1[cH:8][cH:9][n:10][cH:11]1>CCO.[H][H].[O-2].[Pt+2]>[CH3:1][NH:2][CH:4]([CH3:3])[CH2:5][CH2:6][n:7]1[cH:8][cH:9][n:10][cH:11]1|US20050107381A1_0431
4.2.35|[C:5]-[C@&H1&+0&D3:4](-[C@&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1])-Br>>[C:5]-[C&H1&+0&D3:4]1-[O&H0&+0&D2:2]-[C&H1&+0&D3:3]-1-[c:1]|[CH3:1][CH2:2][C:3]1([O:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[C@H:11]([C@@H:12]1Br)[OH:13])[CH2:14][CH3:15]>CCC1(C=Cc2ccccc2O1)CC.CCOCC.O=C1CCC(N1Br)=O.O[K]>[CH3:1][CH2:2][C:3]1([O:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[CH:11]2[O:13][CH:12]21)[CH2:14][CH3:15]|EP0360131A1_0113
2.1.1|[C&H3&D1:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][NH2:2].[O:3]=[C:4](Cl)[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11]>ClCCl>[CH3:1][NH:2][C:4](=[O:3])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11]|EP3587402A1_0019
3.5.3|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-[#30&+]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|Cl[c:1]1[cH:2][cH:3][n:4][c:5]([n:6]1)[Cl:7].[cH:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Zn+].[Br-]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1CCOC1.[NH4+].[Cl-]>[Cl:7][c:5]1[n:4][cH:3][cH:2][c:1]([n:6]1)-[c:11]1[cH:10][cH:9][cH:8][cH:13][cH:12]1|US20140221344A1_0724
9.7.43|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[N&H2&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N&H2&D1:1])=[O&H0&D1:3]|[CH3:1][CH2:2][CH2:3][C:4]([F:5])([F:6])[C:7](=[O:8])Cl.[NH2:9][NH2:10]>O=C(Cl)c1ccccc1C(=O)Cl.ClCCl>[CH3:1][CH2:2][CH2:3][C:4]([F:5])([F:6])[C:7](=[O:8])[NH:10][NH2:9]|EP1201661A1_0306
3.5.3|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[n:3]:[c&H0&+0&D3:2](:[s:1])-[#30&+]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][CH2:2][CH:3]([CH2:4][CH3:5])[c:6]1[cH:7][c:8]([n:9][n:10]2[c:11]1[n:12][c:13]([c:14]2-[c:15]1[s:16][cH:17][c:18]([c:19]1[CH3:20])Br)[CH3:21])[CH3:22].[cH:23]1[cH:24][s:25][c:26]([n:27]1)[Zn+].[Br-]>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.CCOC(C)=O.Cl[Pd]Cl.[Fe+2]>[CH3:1][CH2:2][CH:3]([CH2:4][CH3:5])[c:6]1[cH:7][c:8]([n:9][n:10]2[c:11]1[n:12][c:13]([c:14]2-[c:15]1[s:16][cH:17][c:18]([c:19]1[CH3:20])-[c:26]1[n:27][cH:23][cH:24][s:25]1)[CH3:21])[CH3:22]|US20100121052A1_1879
2.6.1|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH2:1]=[CH:2][CH2:3][CH2:4][NH:5][CH2:6][CH:7]([CH3:8])[C:9]1([CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[OH:21].[CH3:22][C:23](=[O:24])Cl>>[CH2:1]=[CH:2][CH2:3][CH2:4][NH:5][CH2:6][CH:7]([CH3:8])[C:9]1([CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[O:21][C:23]([CH3:22])=[O:24]|EP3484894B1_0855
2.3.12|[N&H2&+0&D1:5]-[c:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-n1:c:n:c:c:1>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[N+:8]([O-:9])=[O:10].[O:11]=[C:12]([CH2:13][NH:14][C:15](=[O:16])n1ccnc1)[N:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>Cc1ccccc1>[O-:9][N+:8](=[O:10])[c:6]1[cH:5][cH:4][cH:3][c:2]([cH:7]1)[NH:1][C:15](=[O:16])[NH:14][CH2:13][C:12](=[O:11])[N:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1|US20200172534A1_0802
9.7.264|[F&H0&D1:5]-[C&H1&+0&D3:4](-[F&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[F&H0&D1:5]-[C&H1&+0&D3:4](-[F&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH:2]([CH3:3])[CH:4]([C:5](=[O:6])[OH:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[OH:14].[F:15][CH:16]([F:17])Cl>CCCCCC.C1COCCO1.ClCCl.O[Na].O>[CH3:1][CH:2]([CH3:3])[CH:4]([C:5](=[O:6])[OH:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[O:14][CH:16]([F:15])[F:17]|US08637559B2_0935
2.1.1|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[CH3:1][c:2]1[cH:3][s:4][c:5]([c:6]1[C:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[NH2:15].[CH3:16][C:17](=[O:18])Cl>O.CCOCC.c1ccncc1>[CH3:16][C:17](=[O:18])[NH:15][c:5]1[s:4][cH:3][c:2]([c:6]1[C:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[CH3:1]|US20200323209A1_0479
9.7.264|[C:5]-[O&H1&+0&D1:4].[F&H0&D1:3]-[C&H1&+0&D3:2](-[F&H0&D1:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H1&+0&D3:2](-[F&H0&D1:3])-[F&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH2:11][N:12]1[C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[OH:20].[F:21][CH:22]([F:23])Cl>CCCC[N+](CCCC)(CCCC)CCCC.C1CCOC1.O[K].[F-]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH2:11][N:12]1[C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[O:20][CH:22]([F:21])[F:23]|US06762321B2
2.6.1|[C&H3&D1:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=[O:9])Cl.[CH3:10][OH:11]>c1ccccc1>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=[O:9])[O:11][CH3:10]|EP2762466A1_0286
2.1.11|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[N:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N:1])=[O&H0&D1:3]|[CH3:1][n:2]1[c:3]([n:4][cH:5][c:6]1[N+:7]([O-:8])=[O:9])[C:10]1=[CH:11][NH:12][N:13]([O:14]1)[NH2:15].[CH3:16][C:17](=[O:18])Cl>c1ccccc1.c1ccncc1.O>[CH3:16][C:17](=[O:18])[NH:15][N:13]1[NH:12][CH:11]=[C:10]([O:14]1)[c:3]1[n:4][cH:5][c:6]([n:2]1[CH3:1])[N+:7]([O-:8])=[O:9]|US20190031641A1_0342
3.9.23|[C&H2&+0&D1:5]=[C&H0&+0&D3:4](-[C:3])-[C:2].[C&H2&+0&D2:1](-I)-I>>[C&H2&+0&D2:5]1-[C&H2&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C:3])-[C:2]|[CH2:1]=[C:2]1[CH2:3][CH2:4][C@@:5]2([CH:6]3[CH2:7][CH2:8][C@@:9]4([C@H:10]([CH2:11][CH2:12][CH:13]4[CH:14]3[C@H:15]3[O:16][C:17]([O:18][C@@H:19]3[CH:20]2[CH2:21]1)([CH3:22])[CH3:23])[O:24][Si:25]([CH3:26])([CH3:27])[C:28]([CH3:29])([CH3:30])[CH3:31])[CH3:32])[CH3:33].I[CH2:34]I>[Cu].[Zn]>[CH3:29][C:28]([CH3:30])([CH3:31])[Si:25]([CH3:26])([CH3:27])[O:24][C@H:10]1[CH2:11][CH2:12][CH:13]2[CH:14]3[C@H:15]4[O:16][C:17]([O:18][C@@H:19]4[CH:20]4[CH2:21][C:2]5([CH2:3][CH2:4][C@@:5]4([CH:6]3[CH2:7][CH2:8][C@:9]12[CH3:32])[CH3:33])[CH2:1][CH2:34]5)([CH3:22])[CH3:23]|US20200207758A1_0147
9.7.259|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3].[N&H3&+&D1:2]-[O&H1&D1:1]>>[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[O&H1&D1:1])-[c:3]|[CH3:1][CH2:2][CH2:3][CH:4]([O:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[C:12]#[N:13])[C:14](=[O:15])[NH:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)-[c:23]1[cH:24][cH:25][cH:26][cH:27][c:28]1[S:29]([CH3:30])(=[O:31])=[O:32].[NH3+:33][OH:34].[Cl-].Cl>CCN(CC)CC.CO.O>[CH3:30][S:29](=[O:31])(=[O:32])[c:28]1[cH:27][cH:26][cH:25][cH:24][c:23]1-[c:20]1[cH:19][cH:18][c:17]([cH:22][cH:21]1)[NH:16][C:14](=[O:15])[CH:4]([CH2:3][CH2:2][CH3:1])[O:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[C:12](=[NH:13])[NH:33][OH:34]|US20190322631A1_0303
1.8.13|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[C:2]-[S&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[S&H0&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])Cl.[SH:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][o:10]1>>[CH3:1][C:2](=[O:3])[S:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][o:10]1|US08604211B2_0170
2.4.5|[C&H3&D1:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[O:1]=[C:2](Cl)[O:3][CH:4]([Cl:5])[C:6]([Cl:7])([Cl:8])[Cl:9].[CH3:10][NH2:11]>ClCCl>[CH3:10][NH:11][C:2](=[O:1])[O:3][CH:4]([Cl:5])[C:6]([Cl:7])([Cl:8])[Cl:9]|US20150329521A1_0072
2.3.7|[N&H2&+0&D1:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[n:1])-n1:c:n:c:c:1>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:7])[c:8]1[cH:9][s:10][c:11]([n:12]1)[NH2:13].[O:14]=[C:15]([n:16]1[cH:17][n:18][cH:19][cH:20]1)n1cncc1>C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:7])[c:8]1[cH:9][s:10][c:11]([n:12]1)[NH:13][C:15](=[O:14])[n:16]1[cH:20][cH:19][n:18][cH:17]1|US20200172534A1_0701
3.9.60|[C:6]-[C&H1&+0&D3:5](-[C:4])-[#30]-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][n:7]([c:8]2[n:9][cH:10][c:11]([cH:12][c:13]12)Br)[S:14](=[O:15])(=[O:16])[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[CH3:23].[CH3:24][C:25]([CH3:26])([CH3:27])[O:28][C:29](=[O:30])[N:31]1[CH2:32][CH:33]([CH2:34]1)[Zn]I>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][n:7]([c:8]2[n:9][cH:10][c:11]([cH:12][c:13]12)[CH:33]1[CH2:32][N:31]([CH2:34]1)[C:29](=[O:30])[O:28][C:25]([CH3:24])([CH3:26])[CH3:27])[S:14](=[O:15])(=[O:16])[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[CH3:23]|US20190345119A1_0513
3.5.3|[N:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-[#30&+]>>[N:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[NH:12][C:13](=[O:14])[c:15]1[cH:16][cH:17][c:18]2[S:19][c:20]3[cH:21][cH:22][cH:23][cH:24][c:25]3[C:26](=[N:27][c:28]2[cH:29]1)Cl.[Cl:30][c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[Zn+].[I-]>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCOC(C)=O.C1CCOC1.[NH4+].[Cl-]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[NH:12][C:13](=[O:14])[c:15]1[cH:16][cH:17][c:18]2[S:19][c:20]3[cH:21][cH:22][cH:23][cH:24][c:25]3[C:26](=[N:27][c:28]2[cH:29]1)[c:34]1[cH:33][cH:32][c:31]([cH:36][cH:35]1)[Cl:30]|US20070105819A1_0388
1.8.13|[F&H0&D1:5]-[C&H1&+0&D3:4](-[F&H0&D1:3])-Cl.[S&H1&+0&D1:2]-[c:1]>>[F&H0&D1:5]-[C&H1&+0&D3:4](-[F&H0&D1:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([n:6][c:7]([n:8]1)[NH2:9])[SH:10].[F:11][CH:12]([F:13])Cl>CCOC(C)=O.C1COCCO1.O[Na].O>[CH3:1][O:2][c:3]1[cH:4][c:5]([n:6][c:7]([n:8]1)[NH2:9])[S:10][CH:12]([F:11])[F:13]|EP3666758A1_0419
2.1.41|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[O&H1&D1:1])=[O&H0&D1:3]|[NH2:1][OH:2].[O:3]=[C:4](Cl)[CH2:5][c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[F:12])-[c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[F:19])[F:20]>O.CCOCC>[O:3]=[C:4]([CH2:5][c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[F:12])-[c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[F:19])[F:20])[NH:1][OH:2]|US08785659B2_0071
4.1.47|[N&H2&+0&D1:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[N&H0&+0&D2:1](-[O&-])=O>>[n&H0&+0&D2:5]1:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c:3]:[c:4]:1|[Na+].[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[NH2:8])[Br:9].[O-][N:10]=O>O.O=S(=O)(O)O>[Br:9][c:4]1[cH:5][cH:6][c:7]2[nH:8][n:10][n:1][c:2]2[cH:3]1|US20100305093A1_1497
3.5.3|[C:6]-[C&H1&+0&D3:5](-[C:4])-[#30&+].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][O:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21])Cl.[CH2:22]1[CH2:23][CH2:24][CH:25]([CH2:26][CH2:27]1)[Zn+].C1CCOC1.[Br-]>CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CN1CCCC1=O.[Pd]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][O:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21])[CH:25]1[CH2:26][CH2:27][CH2:22][CH2:23][CH2:24]1|US07572811B2_0170
2.1.1|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[CH3:1][C:2](=[O:3])Cl.[CH3:4][C:5]1([CH:6]2[CH2:7][CH2:8][C:9]1([CH2:10][CH2:11]2)[NH2:12])[CH3:13]>c1ccncc1>[CH3:1][C:2](=[O:3])[NH:12][C:9]12[CH2:8][CH2:7][CH:6]([CH2:11][CH2:10]2)[C:5]1([CH3:4])[CH3:13]|EP3426638B1_0296
2.1.40|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O-N1-C-C-C-C-1.[C:2]-[N&H2&+0&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[NH2:1][C@@H:2]([CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[OH:10])[C:11](=[O:12])[OH:13].[O:14]=[C:15]([CH:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[F:24])ON1CCCC1>O.O=C(O)O[Na].C1COCCO1>[O:14]=[C:15]([CH:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[F:24])[NH:1][C@@H:2]([CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[OH:10])[C:11](=[O:12])[OH:13]|EP3086814B1_0512
3.5.3|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[n:1])-[#30&+]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15])[c:16]1[cH:17][n:18][cH:19][c:20]([n:21]1)Cl.[CH3:22][c:23]1[cH:24][cH:25][cH:26][c:27]([n:28]1)[Zn+].[Br-]>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1CCOC1>[CH3:22][c:23]1[cH:24][cH:25][cH:26][c:27]([n:28]1)-[c:20]1[cH:19][n:18][cH:17][c:16]([n:21]1)[N:8]([C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15]|US20070213338A1_0295
1.7.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-Br.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[OH:11])[OH:12].[CH3:13][CH:14]([CH3:15])Br>O.[Na+].CO.CCOCC.C[O-]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[OH:11])[O:12][CH:14]([CH3:13])[CH3:15]|EP3013796B9_0396
1.1.7|[C&H3&+0&D1:5]-I.[C&H3&D1:4]-[N&H0&+0&D3:3](-[C&H3&D1:2])-[C:1]>>[C&H3&+0&D1:5]-[N&H0&+&D4:3](-[C&H3&D1:4])(-[C&H3&D1:2])-[C:1]|[CH3:1]I.[CH3:2][N:3]([CH3:4])[CH2:5][CH2:6][CH2:7][c:8]1[cH:9][nH:10][c:11]([cH:12]1)[Br:13]>>[CH3:1][N+:3]([CH3:2])([CH3:4])[CH2:5][CH2:6][CH2:7][c:8]1[cH:9][nH:10][c:11]([cH:12]1)[Br:13]|
1.7.9|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-Br.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH:2]([CH3:3])Br.[OH:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][OH:11]>>[CH3:1][CH:2]([CH3:3])[O:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][OH:4]|US20200017461A1_1880
1.2.15|[C:6]-[C&H2&+0&D2:5]-[C:4].[N&H0&+0&D1:3]#[N&H0&+&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](-[C:4])=[N&H0&+0&D2:3]-[N&H1&+0&D2:2]-[c:1]|[Cl-].[CH3:1][C:2](=[O:3])[CH2:4][C:5](=[O:6])[N:7]([CH2:8][CH3:9])[CH2:10][CH3:11].[N:12]#[N+:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>O.CCO.CC(=O)O[Na]>[CH3:11][CH2:10][N:7]([CH2:8][CH3:9])[C:5](=[O:6])[C:4](=[N:12][NH:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)[C:2]([CH3:1])=[O:3]|US08372837B2_0368
2.1.27|[N&H2&+0&D1:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-n1:c:n:c:c:1>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][O:2][C:3](=[O:4])n1ccnc1.[NH2:5][c:6]1[cH:7][c:8]([n:9][c:10]([n:11]1)[NH2:12])[Cl:13]>CCOCC.CC(C)(C)[O-].C1CCOC1.[K+]>[CH3:1][O:2][C:3](=[O:4])[NH:5][c:6]1[cH:7][c:8]([n:9][c:10]([n:11]1)[NH2:12])[Cl:13]|US20150133512A1_0256
3.5.3|[C:6]-[C&H1&+0&D3:5](-[C:4])-[#30&+].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C@H:11]2[C@@H:12]([CH2:13]1)[c:14]1[cH:15][c:16]([cH:17][c:18]3[c:19]1[N:20]2[CH2:21][CH2:22][CH2:23][S:24]3)Br.[CH2:25]1[CH2:26][CH2:27][CH:28]([CH2:29][CH2:30]1)[Zn+].[Br-]>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.C1CCOC1.Cl[Pd]Cl.I[Cu].[Fe+2]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C@H:11]2[C@@H:12]([CH2:13]1)[c:14]1[cH:15][c:16]([cH:17][c:18]3[c:19]1[N:20]2[CH2:21][CH2:22][CH2:23][S:24]3)[CH:28]1[CH2:29][CH2:30][CH2:25][CH2:26][CH2:27]1|US10836764B2_1488
2.1.27|[N&H2&+0&D1:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-n1:c:n:c:c:1>>[N&H1&+0&D2:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:8])[C@@H:9]([NH:10][C:11](=[O:12])[c:13]1[cH:14][cH:15][c:16]2[n:17][c:18]([cH:19][cH:20][c:21]2[cH:22]1)[NH2:23])[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1.[O:30]=[C:31]([c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1-[c:38]1[cH:39][cH:40][c:41]([cH:42][cH:43]1)[C:44]([F:45])([F:46])[F:47])n1ccnc1>>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:8])[C@@H:9]([NH:10][C:11](=[O:12])[c:13]1[cH:14][cH:15][c:16]2[n:17][c:18]([cH:19][cH:20][c:21]2[cH:22]1)[NH:23][C:31](=[O:30])[c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1-[c:38]1[cH:39][cH:40][c:41]([cH:42][cH:43]1)[C:44]([F:45])([F:46])[F:47])[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1|US10479765B2_0811
1.8.12|[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-Br.[S&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H1&+0&D3:4](-[C&H3&D1:3])-[S&H0&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[SH:8].[CH3:9][CH:10]([CH3:11])Br>C1COCCO1.[Na+].[OH-]>[CH3:9][CH:10]([CH3:11])[S:8][c:6]1[cH:7][c:2]([cH:3][cH:4][cH:5]1)[NH2:1]|US20170121322A1_0890
1.1.7|[C&H3&D1:6]-[C&H2&+0&D2:5]-I.[C:4]-[N&H0&+0&D3:3](-[C:2])-[C:1]>>[C&H3&D1:6]-[C&H2&+0&D2:5]-[N&H0&+&D4:3](-[C:4])(-[C:2])-[C:1]|[CH3:1][CH2:2]I.[CH3:3][CH:4]1[CH2:5][C:6]([CH2:7][CH:8]([CH2:9]1)[N:10]1[CH2:11][CH2:12][CH2:13][CH2:14]1)([CH3:15])[CH3:16]>>[CH3:3][CH:4]1[CH2:5][C:6]([CH2:7][CH:8]([CH2:9]1)[N+:10]1([CH2:11][CH2:12][CH2:13][CH2:14]1)[CH2:2][CH3:1])([CH3:15])[CH3:16]|
2.1.1|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[C:2]=[N&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H0&+0&D2:1]=[C:2])=[O&H0&D1:3]|[NH:1]=[C:2]1[NH:3][SH:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12)(=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[CH3:18][C:19](=[O:20])Cl>CCN(CC)CC.C1COCCO1.O>[CH3:18][C:19](=[O:20])[N:1]=[C:2]1[NH:3][SH:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12)(=[O:11])[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US20190389865A1_0288
9.7.259|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3].[N&H3&+&D1:2]-[O&H1&D1:1]>>[N&H2&+0&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[O&H1&D1:1])-[c:3]|[Cl-].[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[c:12]1[NH2:13].[NH3+:14][OH:15]>O.CCO.O=C(O)O[Na]>[NH2:1][C:2](=[N:14][OH:15])[c:3]1[cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[c:12]1[NH2:13]|EP2227466B1_0458
2.6.1|[C&H3&D1:5]-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][CH:2]([C:3](=[O:4])Cl)[c:5]1[cH:6][cH:7][c:8]2[C:9]([c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][CH2:17][c:18]2[cH:19]1)=[O:20].[CH3:21][OH:22]>O.CCOCC.ClCCl.c1ccncc1>[CH3:21][O:22][C:3](=[O:4])[CH:2]([CH3:1])[c:5]1[cH:6][cH:7][c:8]2[C:9]([c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][CH2:17][c:18]2[cH:19]1)=[O:20]|US20200055995A1_0053
2.1.1|[C&H3&D1:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][CH:2]([C:3](=[O:4])Cl)[c:5]1[cH:6][cH:7][c:8]2[C:9]([c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][CH2:17][c:18]2[cH:19]1)=[O:20].[CH3:21][NH2:22]>ClCCl>[CH3:1][CH:2]([C:3](=[O:4])[NH:22][CH3:21])[c:5]1[cH:6][cH:7][c:8]2[C:9]([c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][CH2:17][c:18]2[cH:19]1)=[O:20]|EP2074086B1_0369
2.6.1|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][n:2]1[n:3][c:4]([c:5]([c:6]1[OH:7])[C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[Cl:16])[CH3:17].[CH3:18][C:19](=[O:20])Cl>CCN(CC)CC.c1ccccc1.O>[CH3:18][C:19](=[O:20])[O:7][c:6]1[c:5]([c:4]([n:3][n:2]1[CH3:1])[CH3:17])[C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[Cl:16]|EP3313817B1_0093
4.1.13|[C&H3&+0&D1:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[N&H0&+0&D2:1](-[O&-])=O>>[c&H1&+0&D2:5]1:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c:3]:[c:4]:1|[Na+].[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[NH2:11])[CH3:12].[O-][N:13]=O>O.CC(=O)O>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[cH:12][n:13][nH:11][c:9]2[cH:10]1|US20200131176A1_1043
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]-[N&H2&+&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[Cl-].[CH2:1]=[CH:2][CH2:3][NH2+:4][CH2:5][S:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.[O:13]=[C:14](O)[C@H:15]1[CH2:16][O:17]1>ClCCl.C(=NC1CCCCC1)=NC1CCCCC1.C1=NCCCN2CCCCC12.C1CCCC2=NCCCN2C1>[CH2:1]=[CH:2][CH2:3][N:4]([CH2:5][S:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[C:14](=[O:13])[C@H:15]1[CH2:16][O:17]1|EP2831056B1_0048
2.3.9|[C&H3&D1:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][CH2:2][N:3]([C:4](=[O:5])[N:6]([CH3:7])[C:8](=[O:9])Cl)[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH3:16][NH2:17]>CCOCC.CC(Cl)Cl>[CH3:1][CH2:2][N:3]([C:4](=[O:5])[N:6]([CH3:7])[C:8](=[O:9])[NH:17][CH3:16])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US20070225496A1_0057
3.5.3|[C:6]-[C&H1&+0&D3:5](-[C:4])-[#30&+].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[n:3][c:4]([cH:5][s:6]1)[C:7]#[C:8][c:9]1[cH:10][cH:11][c:12]([n:13][cH:14]1)Cl.[CH2:15]1[CH2:16][CH2:17][CH:18]([CH2:19][CH2:20]1)[Zn+].[Br-]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1CCOC1>[CH3:1][c:2]1[n:3][c:4]([cH:5][s:6]1)[C:7]#[C:8][c:9]1[cH:10][cH:11][c:12]([n:13][cH:14]1)[CH:18]1[CH2:19][CH2:20][CH2:15][CH2:16][CH2:17]1|US20200069657A1_0404
2.1.1|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[S:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[S:1])=[O&H0&D1:3]|[CH3:1][C:2](=[O:3])Cl.[NH2:4][S:5](=[O:6])(=[O:7])[c:8]1[cH:9][n:10][cH:11][c:12]([cH:13]1)[N+:14]([O-:15])=[O:16]>O=C(O[Na])O[Na]>[CH3:1][C:2](=[O:3])[NH:4][S:5](=[O:6])(=[O:7])[c:8]1[cH:9][n:10][cH:11][c:12]([cH:13]1)[N+:14]([O-:15])=[O:16]|US20200148705A1_0859
3.5.3|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-[#30&+]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Br:1][c:2]1[cH:3][n:4][cH:5][c:6]([cH:7]1)Br.[cH:8]1[cH:9][cH:10][n:11][c:12]([cH:13]1)[Zn+].[Cl-]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CCOC(C)=O.C1CCOC1.[Pd].[Pd]>[Br:1][c:2]1[cH:3][n:4][cH:5][c:6]([cH:7]1)-[c:12]1[cH:13][cH:8][cH:9][cH:10][n:11]1|US06903086B2_0161
3.9.23|[C&H2&+0&D1:5]=[C&H0&+0&D3:4](-[C:3])-[c:2].[C&H2&+0&D2:1](-I)-I>>[C&H2&+0&D2:5]1-[C&H2&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C:3])-[c:2]|[CH2:1]=[C:2]([CH2:3][C:4]([OH:5])([C:6](=[O:7])[O:8][CH2:9][CH3:10])[C:11]([F:12])([F:13])[F:14])[c:15]1[cH:16][c:17]([cH:18][cH:19][c:20]1[O:21][CH3:22])[F:23].I[CH2:24]I>CCOC(C)=O.CCOCC.II.[Cu].[Zn]>[CH3:10][CH2:9][O:8][C:6](=[O:7])[C:4]([OH:5])([CH2:3][C:2]1([CH2:1][CH2:24]1)[c:15]1[cH:16][c:17]([cH:18][cH:19][c:20]1[O:21][CH3:22])[F:23])[C:11]([F:12])([F:13])[F:14]|US20140031300A1_0268
2.1.2|[C:6]-[N&H2&+&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH:2]([CH3:3])[O:4][C:5](=[O:6])[c:7]1[n:8][cH:9][cH:10][cH:11][c:12]1[C:13](=[O:14])O.[O:15]=[C:16]1[CH2:17][NH2+:18][CH2:19][CH2:20][N:21]1[CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29].[O-]C(=O)C(F)(F)F>CCN(CC)CC.CN(C)C=O.ClCCCl.ClCCl>[CH3:1][CH:2]([CH3:3])[O:4][C:5](=[O:6])[c:7]1[n:8][cH:9][cH:10][cH:11][c:12]1[C:13](=[O:14])[N:18]1[CH2:17][C:16]([N:21]([CH2:20][CH2:19]1)[CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29])=[O:15]|US20090062251A1_0582
2.1.2|[C:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[s:6][c:7]([cH:8][c:9]2[cH:10]1)-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[CH:17]=[CH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[C:25](=[O:26])O.[CH2:27]1[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]1>Cl.CNC.O=C(O)c1ccc(cc1)C=Cc1ccc(cc1)-c1cc2cc(ccc2o1)Cl.[Na].[K]>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[s:6][c:7]([cH:8][c:9]2[cH:10]1)-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[CH:17]=[CH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[C:25](=[O:26])[N:30]1[CH2:29][CH2:28][CH2:27][CH2:32][CH2:31]1|US06900200B2_0506
3.11.2|[C&H3&D1:6]-[C&H2&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][C:3](=[O:4])[CH2:5][CH2:6][C:7]1([CH2:8][c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[C:15]1=O)[O:16][CH3:17])[CH2:18][CH2:19][CH2:20][CH3:21]>Cl.CC(=O)O>[CH3:17][O:16][c:11]1[cH:12][cH:13][c:14]2[C:15]3=[C:2]([C:3]([CH2:5][CH2:6][C:7]3([CH2:8][c:9]2[cH:10]1)[CH2:18][CH2:19][CH2:20][CH3:21])=[O:4])[CH3:1]|EP1339683B1_0317
1.2.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[C:3]-[C&H1&+0&D3:2](-[c:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][NH:2][c:3]1[n:4][c:5]([n:6][cH:7][c:8]1[O:9][CH2:10][CH:11](O)[c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[CH3:18])[O:19][CH3:20])[Cl:21]>O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.CCN(CC)CC.ClCCl>[CH3:20][O:19][c:15]1[cH:14][cH:13][c:12]([c:17]([cH:16]1)[CH3:18])[CH:11]1[CH2:10][O:9][c:8]2[cH:7][n:6][c:5]([n:4][c:3]2[N:2]1[CH3:1])[Cl:21]|US08455646B2_0412
1.8.17|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[C:3].[S&H1&+0&D1:2]-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D3:4](-[C:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]=[CH:6][CH2:7][C:8](=[O:9])[O:10][CH3:11].[CH3:12][O:13][c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[SH:20])[N+:21]([O-:22])=[O:23]>>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH:6]([CH2:7][C:8](=[O:9])[O:10][CH3:11])[S:20][c:18]1[cH:19][c:14]([cH:15][cH:16][c:17]1[N+:21]([O-:22])=[O:23])[O:13][CH3:12]|US04863922A
1.3.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[n:3][c:4]([s:5][c:6]1[C:7](=[O:8])[NH:9][CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[F:17])-[c:18]1[cH:19][n:20][cH:21][c:22]([n:23]1)I.[CH3:24][NH:25][CH2:26][c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)[F:33]>CC(C)N(CC)C(C)C.CC(=O)N(C)C.ClCCl>[CH3:1][c:2]1[n:3][c:4]([s:5][c:6]1[C:7](=[O:8])[NH:9][CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[F:17])-[c:18]1[cH:19][n:20][cH:21][c:22]([n:23]1)[N:25]([CH3:24])[CH2:26][c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)[F:33]|EP3071567B1_0252
1.8.17|[C:6]-[S&H1&+0&D1:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C:6]-[S&H0&+0&D2:5]-[C&H1&+0&D3:2](-[C:1])-[C&H2&+0&D2:3]-[C:4]|[O:1]=[C:2]1[CH:3]=[CH:4][C:5]([CH:6]2[CH:7]1[C:8]1([C:9](=[C:10]([C:11]2([C:12]1([Cl:13])[Cl:14])[Cl:15])[Cl:16])[Cl:17])[Cl:18])=[O:19].[CH3:20][CH2:21][CH2:22][CH2:23][SH:24]>c1ccccc1.[Cl-].[Cl-].[Cl-].[Fe+3]>[CH3:20][CH2:21][CH2:22][CH2:23][S:24][CH:3]1[CH2:4][C:5]([CH:6]2[CH:7]([C:2]1=[O:1])[C:8]1([C:9](=[C:10]([C:11]2([C:12]1([Cl:13])[Cl:14])[Cl:15])[Cl:16])[Cl:17])[Cl:18])=[O:19]|US08822460B2_0405
1.7.12|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[c:3].[O&H1&+0&D1:2]-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH:8]=[CH:9][C:10](=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[OH:18]>O.COCCO.O=P(O)(O)O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH:8]1[CH2:9][C:10]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[O:18]1)=[O:11]|US20150299188A1_0680
1.2.5|[C&H3&D1:6]-[C&H0&+0&D3:5](-[c:4])=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][cH:6][cH:7][n:8]1.[CH2:9]1[CH2:10][CH2:11][NH:12][CH2:13]1>[Na+].[Na+].Cl.CO.N#C[BH3-].[OH-]>[CH3:1][CH:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][n:8]1)[N:12]1[CH2:11][CH2:10][CH2:9][CH2:13]1|EP3129371B1_0238
1.7.12|[C:6]/[C&H1&+0&D2:5]=[C&H1&+0&D2:4]/[C:3].[C:2]-[O&H1&+0&D1:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]/[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18](=[O:19])[O:20][CH3:21].[CH3:22][C:23]([CH3:24])([CH3:25])[C:26](=[O:27])[OH:28]>>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH:10]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18](=[O:19])[O:20][CH3:21])[O:28][C:26](=[O:27])[C:23]([CH3:22])([CH3:24])[CH3:25]|US20120295923A1_0218
1.7.12|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[C:3].[O&H1&+0&D1:2]-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:2]-[c:1]|[O:1]=[C:2]([OH:3])[CH:4]=[CH:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[OH:14]>Cl.O=C(O[Na])O[Na]>[O:7]=[C:6]1[CH2:5][CH:4]([O:14][c:13]2[cH:12][cH:11][cH:10][cH:9][c:8]12)[C:2](=[O:1])[OH:3]|US20200347043A1_0966
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|Cl.[CH3:1][N:2]1[CH2:3][CH2:4][c:5]2[c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[nH:12][c:13]2[CH:14]1[CH2:15][CH2:16][CH2:17][C:18](=[O:19])O>O.O.O=P(O)(O)O.O[Na]>[CH3:1][N:2]1[CH2:3][CH2:4][c:5]2[c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[n:12]3[C:18]([CH2:17][CH2:16][CH2:15][CH:14]1[c:13]23)=[O:19]|US09643923B2_1036
1.2.17|[C:6]-[C&H0&+0&D2:5]#[C&H0&+0&D2:4]-[C:3].[N&H2&+0&D1:2]-[c:1]>>[C:6]-[C&H1&+0&D2:5]=[C&H0&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]#[C:6][C:7](=[O:8])[O:9][CH3:10].[NH2:11][c:12]1[cH:13][o:14][c:15]2[cH:16][cH:17][c:18]([cH:19][c:20]2[c:21]1=[O:22])[Cl:23]>CO>[CH3:10][O:9][C:7](=[O:8])[CH:6]=[C:5]([NH:11][c:12]1[cH:13][o:14][c:15]2[cH:16][cH:17][c:18]([cH:19][c:20]2[c:21]1=[O:22])[Cl:23])[C:3](=[O:4])[O:2][CH3:1]|US07939537B2_0466
1.3.8|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][NH:2][C@H:3]1[CH2:4][CH2:5][C@@H:6]([CH2:7][CH2:8]1)[C:9]#[C:10][CH2:11][OH:12].F[c:13]1[cH:14][cH:15][c:16]([cH:17][n:18]1)[Br:19]>CC(C)N(CC)C(C)C.CN(C)C=O.I[Na]>[CH3:1][N:2]([c:13]1[cH:14][cH:15][c:16]([cH:17][n:18]1)[Br:19])[C@H:3]1[CH2:4][CH2:5][C@@H:6]([CH2:7][CH2:8]1)[C:9]#[C:10][CH2:11][OH:12]|US20120083489A1_0172
3.5.2|[C:6]-[C&H1&+0&D3:5](-[C:4])-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][c:4]([n:5][nH:6]1)[NH:7][c:8]1[cH:9][c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[c:16]([n:17]1)Cl)[O:18][CH3:19].Br[Mg][CH:20]1[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1>>[CH3:19][O:18][c:12]1[cH:13][cH:14][c:15]2[c:10]([cH:9][c:8]([n:17][c:16]2[CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[NH:7][c:4]2[cH:3][c:2]([nH:6][n:5]2)[CH3:1])[cH:11]1|US20170349594A1_1661
9.7.259|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3].[N&H2&+0&D1:2]-[O&H1&D1:1]>>[N&H2&+0&D1:5]/[C&H0&+0&D3:4](=[N&H0&+0&D2:2]/[O&H1&D1:1])-[c:3]|Cl.[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[Cl:9].[NH2:10][OH:11]>O.[Na+].CCO.[OH-]>[NH2:1]/[C:2](=[N:10]/[OH:11])[c:3]1[cH:8][c:7]([cH:6][cH:5][cH:4]1)[Cl:9]|US20200048279A1_0250
2.1.2|[C:6]-[N&H1&+0&D2:5]-[C:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][SH:2]1[C:3]2[CH:4]=[CH:5][CH2:6][C:7]=2[C:8]2[CH2:9][N:10]([CH2:11][CH:12]3[N:13]([NH:14][CH2:15][N:16]3[C:17]=21)[C:18](=[O:19])O)[c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1[Cl:26].[CH2:27]1[CH2:28][O:29][CH2:30][CH2:31][NH:32]1>CCO.C(=NC1CCCCC1)=NC1CCCCC1>[CH3:1][SH:2]1[C:3]2[CH:4]=[CH:5][CH2:6][C:7]=2[C:8]2[CH2:9][N:10]([CH2:11][CH:12]3[N:13]([NH:14][CH2:15][N:16]3[C:17]=21)[C:18](=[O:19])[N:32]1[CH2:27][CH2:28][O:29][CH2:30][CH2:31]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1[Cl:26]|US20200308190A1_0691
1.2.16|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[c:3].[N&H2&+0&D1:2]-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[c:3]|[CH3:1][c:2]1[n:3][c:4]2[c:5]([c:6]([cH:7][cH:8][n:9]2[c:10]1[CH3:11])[C:12](=[O:13])[CH:14]=[CH:15][c:16]1[cH:17][cH:18][s:19][cH:20]1)[NH2:21]>O=S(=O)(O)O.O[Na]>[CH3:1][c:2]1[n:3][c:4]2[c:5]3[NH:21][CH:15]([CH2:14][C:12]([c:6]3[cH:7][cH:8][n:9]2[c:10]1[CH3:11])=[O:13])[c:16]1[cH:17][cH:18][s:19][cH:20]1|EP2740734A1_0106
3.5.2|[c:6]:[c&H0&+0&D3:5](:[c:4])-[#12]-Br.[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|Cl[c:1]1[n:2][c:3]([n:4][c:5]([n:6]1)[Cl:7])[Cl:8].Br[Mg][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>>[Cl:8][c:3]1[n:4][c:5]([n:6][c:1]([n:2]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[Cl:7]|US20120172361A1_0296
1.2.16|[C:6]-[N&H2&+0&D1:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H1&+0&D3:2](-[C:1])-[C&H2&+0&D2:3]-[C:4]|Cl.[CH3:1][C@H:2]([NH2:3])[C:4](=[O:5])[N:6]1[CH2:7][CH2:8][CH2:9][C@H:10]1[C:11](=[O:12])[OH:13].[O:14]=[C:15]([OH:16])[CH:17]=[CH:18][C:19](=[O:20])[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>O.CO.CCCCO.CCOC(C)=O.CC(=O)O.O=C(O)O[Na]>[CH3:1][C@H:2]([NH:3][CH:17]([CH2:18][C:19](=[O:20])[c:21]1[cH:26][cH:25][cH:24][cH:23][cH:22]1)[C:15](=[O:14])[OH:16])[C:4](=[O:5])[N:6]1[CH2:7][CH2:8][CH2:9][C@H:10]1[C:11](=[O:12])[OH:13]|US20190389798A1_0215
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH:2]([S:3][c:4]1[n:5][c:6]([n:7][nH:8]1)[S:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])O>O.O.CC(=O)OCC.O=P(O)(O)O>[CH3:1][CH:2]1[S:3][c:4]2[n:5][c:6]([n:7][n:8]2[C:17]1=[O:18])[S:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US20200369677A1_0445
2.5.6|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3].[N&H2&+0&D1:2]-[N&H2&D1:1]>>[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N&H2&D1:1])-[c:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[O:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH3:17])[C:18]([CH3:19])([CH3:20])[CH3:21])[C:22]#[N:23].[NH2:24][NH2:25]>O=C(O)O[Na].C1CCOC1.O.[NaH]>[CH3:17][O:16][CH2:15][CH2:14][O:13][CH2:12][O:11][c:10]1[c:5]([cH:6][c:7]([cH:8][c:9]1[C:18]([CH3:19])([CH3:20])[CH3:21])[C:22](=[NH:23])[NH:24][NH2:25])[C:2]([CH3:1])([CH3:3])[CH3:4]|US20050075375A1_1434
2.1.2|[C:6]-[N&H1&+0&D2:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][S:2][C:3]([CH3:4])([C:5](=[O:6])[OH:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[NH:14][C:15](=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[C:23](=[O:24])O>CC(=O)O>[CH3:1][S:2][C:3]([CH3:4])([C:5](=[O:6])[OH:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[N:14]1[C:23]([c:22]2[cH:21][cH:20][cH:19][cH:18][c:17]2[C:15]1=[O:16])=[O:24]|EP1021411B1_0200
3.9.24|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][SiH:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[C@@H:12]1[CH2:13][CH2:14][C@H:15]([CH2:16][CH2:17]1)[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[Mg]Cl.[F:24][c:25]1[cH:26][cH:27][c:28]([cH:29][c:30]1[F:31])Br>c1ccc(cc1)P(CCCP(c1ccccc1)c1ccccc1)c1ccccc1.C1CCOC1.Cl[Ni]Cl>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][SiH:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[C@H:12]1[CH2:17][CH2:16][C@@H:15]([CH2:14][CH2:13]1)[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)-[c:28]1[cH:27][cH:26][c:25]([c:30]([cH:29]1)[F:31])[F:24]|US20080269514A1_0048
3.7.5|[C&H3&+0&D1:5]-[#12]-I.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH2:7][N:8]([CH2:9][C:10](=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][c:20]([cH:21][cH:22][c:23]1[Cl:24])[Cl:25].[CH3:26][Mg]I>CCOCC>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH2:7][N:8]([CH2:9][C:10]([CH3:26])([OH:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][c:20]([cH:21][cH:22][c:23]1[Cl:24])[Cl:25]|US04337346A
3.9.60|[c:6]:[c&H0&+0&D3:5](:[n:4])-[#30]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[F:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[C:8]([F:9])([F:10])[F:11])Br.Br[Zn][c:12]1[cH:13][cH:14][cH:15][cH:16][n:17]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[C:8]([F:9])([F:10])[F:11])-[c:12]1[cH:13][cH:14][cH:15][cH:16][n:17]1|US08247401B2_0303
9.7.259|[C:5]-[C&H0&+0&D2:4]#[N&H0&+0&D1:3].[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H2&+0&D1:3])=[N&H0&+0&D2:2]-[O&H1&D1:1]|Cl.[N:1]#[C:2][CH2:3][c:4]1[c:5]([n:6][n:7]([c:8]1[Cl:9])-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22].[NH2:23][OH:24]>CCO.O=C(O)O[Na]>[NH2:1][C:2]([CH2:3][c:4]1[c:5]([n:6][n:7]([c:8]1[Cl:9])-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22])=[N:23][OH:24]|US20200331888A1_0744
3.5.4|[c:6]:[c&H0&+0&D3:5](:[c:4])-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][c:12]([n:13]1)Br)([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[F:26][c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)[Mg]Br>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOCC.C1CCOC1.CC([O-])=O.[NH4+].[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][c:12]([n:13]1)-[c:30]1[cH:29][cH:28][c:27]([cH:32][cH:31]1)[F:26])([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US20200131283A1_0657
1.2.5|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[C:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H1&+0&D3:2](-[C:3])-[c:1]|[CH3:1][NH:2][c:3]1[n:4][c:5]([n:6][cH:7][c:8]1[O:9][CH2:10][C:11](=O)[c:12]1[cH:13][c:14]([cH:15][c:16]([cH:17]1)[F:18])[F:19])[Cl:20]>CC(=O)O[BH-](OC(C)=O)OC(C)=O.O=C(O)C(F)(F)F.ClCCCl.[Na+]>[CH3:1][N:2]1[c:3]2[n:4][c:5]([n:6][cH:7][c:8]2[O:9][CH2:10][CH:11]1[c:12]1[cH:17][c:16]([cH:15][c:14]([cH:13]1)[F:19])[F:18])[Cl:20]|US09771378B2_1148
3.11.34|[C&H3&D1:6]-[C&H0&+0&D3:5](-[c:4])=O.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[NH:7][C:8]([CH2:9][c:10]2[cH:11]1)=[O:12].[CH3:13][C:14](=O)[c:15]1[cH:16][cH:17][cH:18][nH:19]1>CCCCCC.CCOC(C)=O.CCOC(C)=O.O=[Si]=O.C1CCNCC1>[CH3:13][C:14](=[C:9]1[C:8]([NH:7][c:6]2[cH:5][cH:4][c:3]([cH:11][c:10]12)[O:2][CH3:1])=[O:12])[c:15]1[cH:16][cH:17][cH:18][nH:19]1|US20200392153A1_1057
2.5.6|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3].[N&H2&+0&D1:2]-[N&H2&D1:1]>>[N&H2&+0&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[N&H2&D1:1])-[c:3]|O.[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][n:8]1.[NH2:9][NH2:10]>CCO>[NH2:10][N:9]=[C:2]([NH2:1])[c:3]1[cH:4][cH:5][cH:6][cH:7][n:8]1|US20200172546A1_1508
1.7.12|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[O:3].[C:2]-[O&H1&+0&D1:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[O:3]|[CH:1]#[C:2][CH:3]([OH:4])[C:5]([CH3:6])([CH3:7])[CH2:8][CH2:9][CH2:10][CH3:11].[CH:12]1=[CH:13][O:14][CH2:15][CH2:16][CH2:17]1>CCN(CC)CC.O=P(Cl)(Cl)Cl>[CH:1]#[C:2][CH:3]([O:4][CH:13]1[CH2:12][CH2:17][CH2:16][CH2:15][O:14]1)[C:5]([CH3:6])([CH3:7])[CH2:8][CH2:9][CH2:10][CH3:11]|EP2753290B1_0076
1.3.8|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)F.[CH3:9][NH:10][CH2:11][CH2:12][OH:13]>CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.O=C(O[K])O[K].CS(C)=O.O.[Cl-]>[CH3:9][N:10]([CH2:11][CH2:12][OH:13])[c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[CH:2]=[O:1]|EP3424924A1_0169
1.2.20|[C:6]-[N&H1&+0&D2:5]-[C:4]-[O&H0&+0&D2:3]-[C&H2&+0&D2:2]-[c:1]>>[C:6]-[N&H0&+0&D3:5](-[C&H2&+0&D2:2]-[c:1])-[C:4]-[O&H1&+0&D1:3]|[ClH:1].[CH3:2][CH:3]([CH3:4])[CH2:5][CH2:6][NH:7][C:8](=[O:9])[C@:10]([CH3:11])([CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[OH:19])[NH:20][C:21](=[O:22])[O:23][CH2:24][c:25]1[cH:26][cH:27][n:28][cH:29][cH:30]1>CO.CCOCC.ClCCl>[ClH:1].[CH3:2][CH:3]([CH3:4])[CH2:5][CH2:6][NH:7][C:8](=[O:9])[C@:10]([CH3:11])([CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[OH:19])[N:20]([CH2:24][c:25]1[cH:26][cH:27][n:28][cH:29][cH:30]1)[C:21](=[O:22])[OH:23]|US20080300231A1_0331
2.1.2|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-O.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][c:4]([s:5][c:6]1[C:7](=[O:8])O)[CH3:9].[CH3:10][S:11](=[O:12])(=[O:13])[NH:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[NH:21][c:22]1[n:23][c:24]([nH:25][n:26]1)[NH2:27]>>[CH3:10][S:11](=[O:12])(=[O:13])[NH:14][c:15]1[cH:20][cH:19][c:18]([cH:17][cH:16]1)[NH:21][c:22]1[n:23][c:24]([n:25]([n:26]1)[C:7](=[O:8])[c:6]1[s:5][c:4]([cH:3][c:2]1[CH3:1])[CH3:9])[NH2:27]|US20190194186A1_0187
3.11.2|[C&H3&D1:6]-[C&H2&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][C:3](=[O:4])[CH2:5][CH2:6][C:7]1([C:8]([CH2:9][CH2:10][CH2:11][C:12]1=O)=[O:13])[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[O:20][CH3:21]>CC#N.CC1(C2CC[C@@]1(C(C2)=O)CS(=O)(=O)O)C.N[C@@H](Cc1ccccc1)C(=O)O>[CH3:21][O:20][c:18]1[cH:17][cH:16][cH:15][c:14]([cH:19]1)[C:7]12[CH2:6][CH2:5][C:3]([C:2](=[C:12]2[CH2:11][CH2:10][CH2:9][C:8]1=[O:13])[CH3:1])=[O:4]|US20200299230A1_0741
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]-[N&H1&+0&D2:2]-[N:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[N:1]|[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[CH:11]1[CH2:12][C:13](=[N:14][NH:15]1)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[O:22]=[C:23](O)[CH2:24][P:25](=[O:26])([OH:27])[CH2:28][CH2:29][CH2:30][CH2:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.Cl>CCOC(=O)C(Cl)OC(=O)C(C)(C)C.CCN(CC)CC.CN(C)C=O.O=S(Cl)Cl.ClCCl>[O:26]=[P:25]([OH:27])([CH2:28][CH2:29][CH2:30][CH2:31][c:32]1[cH:37][cH:36][cH:35][cH:34][cH:33]1)[CH2:24][C:23](=[O:22])[N:15]1[N:14]=[C:13]([CH2:12][CH:11]1[C:2](=[O:1])[O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US08754100B2_0919
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[O:1]=[C:2](O)[CH2:3][CH2:4][CH2:5][C:6](=[O:7])[NH:8][c:9]1[cH:10][c:11]([cH:12][c:13]([cH:14]1)[Cl:15])[Cl:16]>[Na+].CC([O-])=O.CC(=O)OC(C)=O>[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][C:6]([N:8]1[c:9]1[cH:14][c:13]([cH:12][c:11]([cH:10]1)[Cl:16])[Cl:15])=[O:7]|US20130059874A1_0298
1.9.22|[C:5]-[O&H1&+0&D1:4].[O&H0&-&D1:3]-[N&H0&+&D3:2](=[O&H0&D1:1])-O>>[C:5]-[O&H0&+0&D2:4]-[N&H0&+&D3:2](-[O&H0&-&D1:3])=[O&H0&D1:1]|[CH3:1][C@:2]12[CH2:3][C:4]([C@H:5]3[C@@H:6]([CH2:7][CH2:8][C@H:9]4[CH2:10][C@@H:11]([CH2:12][CH2:13][C@@:14]43[CH3:15])[OH:16])[C@@H:17]1[CH2:18][CH2:19][C@@H:20]2[C:21](=[O:22])[OH:23])=[O:24].[O-:25][N+:26](=[O:27])O>CC(=O)OC(C)=O.O[Na].ClC(Cl)Cl>[CH3:1][C@:2]12[CH2:3][C:4]([C@H:5]3[C@@H:6]([CH2:7][CH2:8][C@H:9]4[CH2:10][C@@H:11]([CH2:12][CH2:13][C@@:14]43[CH3:15])[O:16][N+:26]([O-:25])=[O:27])[C@@H:17]1[CH2:18][CH2:19][C@@H:20]2[C:21](=[O:22])[OH:23])=[O:24]|US05538891A
1.2.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[cH:13]1)O.[CH3:14][NH:15][CH2:16][CH2:17][OH:18]>O.[Na+].CCOC(C)=O.[O-]S(=O)O>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[cH:13]1)[N:15]([CH3:14])[CH2:16][CH2:17][OH:18]|US07223879B2_0821
3.7.5|[C&H3&+0&D1:5]-[#12]-I.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH:2]1[CH2:3][CH2:4][CH2:5][C:6]([C:7]11[CH2:8][CH2:9][CH2:10][CH2:11]1)=[O:12].[CH3:13][Mg]I>>[CH3:1][CH:2]1[CH2:3][CH2:4][CH2:5][C:6]([C:7]11[CH2:8][CH2:9][CH2:10][CH2:11]1)([CH3:13])[OH:12]|US08957104B2_0347
9.7.259|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[N:3].[N&H2&+0&D1:2]-[O&H1&D1:1]>>[N&H2&+0&D1:5]/[C&H0&+0&D3:4](=[N&H0&+0&D2:2]\[O&H1&D1:1])-[N:3]|Cl.[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])[O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][CH2:17][N:18]([C:19]#[N:20])[CH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)-[c:28]1[cH:29][o:30][c:31]([n:32]1)[CH:33]1[CH2:34][CH2:35]1.[NH2:36][OH:37]>[Na+].CC([O-])=O.CN(C)C=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])[O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][CH2:17][N:18]([CH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)-[c:28]1[cH:29][o:30][c:31]([n:32]1)[CH:33]1[CH2:34][CH2:35]1)/[C:19]([NH2:20])=[N:36]/[OH:37]|US20130184257A1_0622
3.11.93|[C:6]-[C&H2&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[O:1]=[C:2]([NH:3][C@@H:4]([CH2:5][c:6]1[cH:7][nH:8][c:9]2[cH:10][cH:11][c:12]([cH:13][c:14]21)[OH:15])[C:16](=[O:17])O)[O:18][CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[CH3:26][C:27]([CH3:28])([CH3:29])[O:30][C:31](=[O:32])[CH2:33][CH2:34][CH2:35][NH2:36]>C(=NC1CCCCC1)=NC1CCCCC1.CC(C)=O.ClC(Cl)Cl>[CH3:26][C:27]([CH3:28])([CH3:29])[O:30][C:31](=[O:32])[CH:33]([CH2:34][CH2:35][NH2:36])[C:16](=[O:17])[C@H:4]([CH2:5][c:6]1[cH:7][nH:8][c:9]2[cH:10][cH:11][c:12]([cH:13][c:14]21)[OH:15])[NH:3][C:2](=[O:1])[O:18][CH2:19][c:20]1[cH:25][cH:24][cH:23][cH:22][cH:21]1|US20200165242A1_0238
1.2.9|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2](O)[c:3]1[cH:4][cH:5][c:6]2[c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[s:13][c:14]2[cH:15]1.[cH:16]1[cH:17][nH:18][cH:19][n:20]1>>[CH3:1][CH:2]([c:3]1[cH:4][cH:5][c:6]2[c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[s:13][c:14]2[cH:15]1)[n:18]1[cH:19][n:20][cH:16][cH:17]1|US20160039842A1_0296
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[N:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[N:3])-[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[N:9]=[N:10][NH:11][c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[C:18]#[N:19])[C:20]([F:21])([F:22])[F:23])[C:24]([F:25])([F:26])[F:27].[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH2:34][CH2:35][C:36](=[O:37])O.[ClH:38]>C(=NC1CCCCC1)=NC1CCCCC1.ClCCl>[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH2:34][CH2:35][C:36](=[O:37])[N:11]([N:10]=[N:9][c:8]1[cH:7][c:6]([cH:5][cH:4][c:3]1[C:2]#[N:1])[C:24]([F:25])([F:26])[F:27])[c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[C:18]#[N:19])[C:20]([F:21])([F:22])[F:23].[ClH:38]|US04424351A
1.2.16|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[C&H3&D1:2]-[N&H2&+0&D1:1]>>[C&H2&+0&D2:5](-[N&H1&+0&D2:1]-[C&H3&D1:2])-[C&H2&+0&D2:4]-[C:3]|[CH2:1]=[CH:2][C:3](=[O:4])[NH:5][CH3:6].[CH3:7][NH2:8]>>[CH3:7][NH:8][CH2:1][CH2:2][C:3](=[O:4])[NH:5][CH3:6]|US20180354972A1_0377
2.5.7|[C:5]-[N&H2&+0&D1:4].[N&H1&D1:3]=[C&H0&+0&D3:2](-[N&H2&D1:1])-S-C>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[N&H1&D1:3])-[N&H2&D1:1]|CS[C:1](=[NH:2])[NH2:3].[NH2:4][CH2:5][CH2:6][CH2:7][S:8][c:9]1[n:10][cH:11][cH:12][o:13]1>>[NH:2]=[C:1]([NH2:3])[NH:4][CH2:5][CH2:6][CH2:7][S:8][c:9]1[n:10][cH:11][cH:12][o:13]1|US20200069691A1_0197
3.5.2|[C:6]-[C&H1&+0&D3:5](-[C:4])-[#12]-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[S:4](=[O:5])(=[O:6])[NH:7][CH2:8][CH:9]([CH3:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)Br.Cl[Mg][CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1>>[CH3:10][CH:9]([CH2:8][NH:7][S:4](=[O:5])(=[O:6])[CH:2]([CH3:1])[CH3:3])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1|US20190081253A1_0110
1.7.12|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[S:3].[C&H3&D1:2]-[O&H1&+0&D1:1]>>[C&H2&+0&D2:5](-[O&H0&+0&D2:1]-[C&H3&D1:2])-[C&H2&+0&D2:4]-[S:3]|[CH2:1]=[CH:2][S:3](=[O:4])(=[O:5])[NH:6][CH2:7][CH:8]([CH3:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)-[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22].[CH3:23][OH:24]>N.[NH4+].[OH-]>[CH3:9][CH:8]([CH2:7][NH:6][S:3](=[O:4])(=[O:5])[CH2:2][CH2:1][O:24][CH3:23])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)-[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22]|US09056865B2_0428
1.2.9|[C&H3&D1:6]-[C&H0&+0&D3:5](=[C:4])-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2](O)=[C:3]([C:4](=[O:5])[O:6][CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[N+:14]([O-:15])=[O:16])[N:17]1[C:18]([CH:19]2[CH:20]1[S:21][C:22](=[N:23]2)[CH2:24][O:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)=[O:32].[CH2:33]1[CH2:34][NH:35][CH2:36][CH2:37][O:38]1>CC(OS(C)(=O)=O)=C(C(=O)OCc1ccc(cc1)[N+]([O-])=O)N1C(C2C1SC(=N2)COc1ccccc1)=O.CCN(CC)CC.CS(=O)(=O)Cl.C1CCOC1>[CH3:1][C:2](=[C:3]([C:4](=[O:5])[O:6][CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[N+:14]([O-:15])=[O:16])[N:17]1[C:18]([CH:19]2[CH:20]1[S:21][C:22](=[N:23]2)[CH2:24][O:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)=[O:32])[N:35]1[CH2:36][CH2:37][O:38][CH2:33][CH2:34]1|EP1764367A1_0695
3.5.2|[c:6]:[c&H0&+0&D3:5](:[c:4])-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[c:2]1[nH:3][n:4][cH:5][c:6]([c:7]1Cl)[Cl:8].Br[Mg][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>[NH4+].[Cl-].C1CCOC1>[O:1]=[c:2]1[nH:3][n:4][cH:5][c:6]([c:7]1-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[Cl:8]|US20190308995A1_0357
9.7.8|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[N&H2&D1:3].[N&H2&+0&D1:2]-[c:1]>>[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])-[N&H2&D1:3]|[N:1]#[C:2][NH2:3].[NH2:4][c:5]1[cH:6][cH:7][c:8]2[cH:9][c:10]3[cH:11][cH:12][c:13]([cH:14][c:15]3[n:16][c:17]2[cH:18]1)[NH2:19]>>[NH:1]=[C:2]([NH2:3])[NH:19][c:13]1[cH:12][cH:11][c:10]2[cH:9][c:8]3[cH:7][cH:6][c:5]([cH:18][c:17]3[n:16][c:15]2[cH:14]1)[NH2:4]|US09809577B2_0742
2.1.2|[C:6]-[N&H1&+0&D2:5]-[N:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:6]-[N&H0&+0&D3:5](-[N:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2]([NH:3][NH:4][C:5](=[O:6])[c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[C:13](=[O:14])O)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CN(C)C=O.O=S(=O)=O>[O:14]=[C:13]1[c:12]2[cH:11][cH:10][cH:9][cH:8][c:7]2[C:5]([N:4]1[NH:3][C:2](=[O:1])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)=[O:6]|US20190322644A1_0149
3.7.5|[C&H3&+0&D1:5]-[#12]-I.[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[O&H1&+0&D1:4])(-[c:2])-[c:1]|[O:1]=[C:2]([c:3]1[cH:4][n:5]([cH:6][n:7]1)[C:8]([c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[c:27]1[cH:28][c:29]([cH:30][c:31]2[CH2:32][O:33][CH2:34][O:35][c:36]21)[Cl:37].[CH3:38][Mg]I>CCOCC.C1CCOC1.[NH4+].O.[Cl-]>[CH3:38][C:2]([OH:1])([c:3]1[cH:4][n:5]([cH:6][n:7]1)[C:8]([c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[c:27]1[cH:28][c:29]([cH:30][c:31]2[CH2:32][O:33][CH2:34][O:35][c:36]21)[Cl:37]|US20110059948A1_0155
3.5.2|[c:6]:[c&H0&+0&D3:5](:[c:4])-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[CH2:9][NH:10][c:11]1[cH:12][cH:13][cH:14][n:15][c:16]1Cl.Br[Mg][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>[Br-].c1cc[c-]cc1.C1CCOC1.[Mg+2]>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[CH2:9][NH:10][c:11]1[cH:12][cH:13][cH:14][n:15][c:16]1-[c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|US20100160386A1_0295
9.7.259|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3].[N&H2&+0&D1:2]-[O&H1&D1:1]>>[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[O&H1&D1:1])-[c:3]|Cl.[CH3:1][O:2][c:3]1[n:4][c:5]2[n:6][c:7]([cH:8][n:9]2[c:10]([c:11]1[CH2:12][CH3:13])[CH3:14])[C:15]#[N:16].[NH2:17][OH:18]>CCO.O[K]>[CH3:13][CH2:12][c:11]1[c:3]([n:4][c:5]2[n:6][c:7]([cH:8][n:9]2[c:10]1[CH3:14])[C:15](=[NH:16])[NH:17][OH:18])[O:2][CH3:1]|EP3290412A1_0104
3.5.3|[c:6]:[c&H0&+0&D3:5](:[c:4])-I.[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#30&+]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH2:8][CH:9]1[CH2:10][CH2:11][n:12]2[c:13]1[c:14]([c:15]1[c:16]2[cH:17][cH:18][c:19]([cH:20]1)[O:21][CH2:22][c:23]1[cH:24][cH:25][c:26]([c:27]([cH:28]1)[C:29]([F:30])([F:31])[F:32])[CH:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1)I.[CH2:38]1[CH2:39][CH:40]1[Zn+].[Br-]>CC(C)(C)[P](C(C)(C)C)(C(C)(C)C)[Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C.C1CCOC1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH2:8][CH:9]1[CH2:10][CH2:11][n:12]2[c:13]1[c:14]([c:15]1[c:16]2[cH:17][cH:18][c:19]([cH:20]1)[O:21][CH2:22][c:23]1[cH:24][cH:25][c:26]([c:27]([cH:28]1)[C:29]([F:30])([F:31])[F:32])[CH:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1)[CH:40]1[CH2:38][CH2:39]1|EP2706852B1_0131
2.1.2|[C:6]-[N&H1&+0&D2:5]-[c:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[Cl:11])[NH:12][C:13](=[O:14])[CH2:15][N:16]([C:17](=[O:18])O)[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>CC(=O)OC(C)=O>[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[Cl:11])[N:12]1[C:17]([N:16]([CH2:15][C:13]1=[O:14])[c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1)=[O:18]|US09981928B2_1557
9.7.300|[N&H3&+0&D0:5].[C:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:2]=[S&H0&D1:1]>>[N&H2&+0&D1:5]-[C&H0&+0&D3:2](=[S&H0&D1:1])-[N&H1&+0&D2:3]-[C:4]|[NH3:1].[CH3:2][N:3]([CH3:4])[C:5](=[O:6])[N:7]=[C:8]=[S:9]>ClCCl>[CH3:2][N:3]([CH3:4])[C:5](=[O:6])[NH:7][C:8]([NH2:1])=[S:9]|US20200317681A1_0130
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H2&+&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[O:1]=[S:2](=[O:3])([NH:4][c:5]1[n:6][c:7]2[CH2:8][CH2:9][NH2+:10][CH2:11][c:12]2[s:13]1)[c:14]1[cH:15][c:16]([cH:17][c:18]([cH:19]1)[C:20]([F:21])([F:22])[F:23])[C:24]([F:25])([F:26])[F:27].[O:28]=[C:29](Cl)[CH2:30][CH:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1.Cl>CC(C)N(CC)C(C)C.[O-]S(=O)(=O)O.ClCCl.[Na+]>[O:1]=[S:2](=[O:3])([NH:4][c:5]1[n:6][c:7]2[CH2:8][CH2:9][N:10]([CH2:11][c:12]2[s:13]1)[C:29](=[O:28])[CH2:30][CH:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1)[c:14]1[cH:15][c:16]([cH:17][c:18]([cH:19]1)[C:20]([F:21])([F:22])[F:23])[C:24]([F:25])([F:26])[F:27]|EP2880031B1_0203
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]-[N&H1&+0&D2:2]-[S:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[S:1]|[O:1]=[S:2](=[O:3])([NH:4][CH2:5][CH2:6][CH2:7][C:8](=[O:9])O)[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16]>C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1>[O:9]=[C:8]1[CH2:7][CH2:6][CH2:5][N:4]1[S:2](=[O:1])(=[O:3])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16]|US20120295903A1_1079
2.1.2|[C:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[cH:1]1[cH:2][c:3]2[CH2:4][NH:5][CH2:6][CH2:7][c:8]2[s:9]1.[CH3:10][C:11]([CH3:12])([CH3:13])[O:14][C:15](=[O:16])O>CCN(CC)CC.ClCCl>[CH3:10][C:11]([CH3:12])([CH3:13])[O:14][C:15](=[O:16])[N:5]1[CH2:6][CH2:7][c:8]2[s:9][cH:1][cH:2][c:3]2[CH2:4]1|US20040106653A1_1654
7.6.1|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][C:2]1[CH2:3][CH2:4][CH:5]2[C:6]=1[CH2:7][CH2:8][CH:9]([CH2:10][CH:11]2[CH3:12])[OH:13]>CCO.[Pd]>[CH3:1][CH:2]1[CH2:3][CH2:4][CH:5]2[CH:11]([CH2:10][CH:9]([CH2:8][CH2:7][CH:6]12)[OH:13])[CH3:12]|US09464082B2_1232
3.11.34|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=O.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]#[N:8].[CH3:9][C:10](=O)[CH2:11][CH2:12][CH2:13][C:14]#[N:15]>[NH4+].CC([O-])=O.CC(=O)O.Cc1ccccc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([C:7]#[N:8])=[C:10]([CH3:9])[CH2:11][CH2:12][CH2:13][C:14]#[N:15]|US20120065195A1_0545
2.1.2|[C:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[n:1])-O>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[n:1]|[O:1]=[C:2](O)[n:3]1[cH:4][cH:5][cH:6][n:7]1.[CH2:8]1[CH2:9][NH:10][CH2:11][CH2:12][O:13]1>CCN(CC)CC.CN(C)C=O.O=S(Cl)Cl.ClCCl>[O:1]=[C:2]([N:10]1[CH2:11][CH2:12][O:13][CH2:8][CH2:9]1)[n:3]1[cH:4][cH:5][cH:6][n:7]1|US20200087304A1_0903
3.11.83|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[C:3].[C:2]-[C&H2&+0&D2:1]-I>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[C:8](=[O:9])[O:10][CH2:11][CH3:12].I[CH2:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[O:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH2:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[O:21][CH2:22][c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1)[C:8](=[O:9])[O:10][CH2:11][CH3:12]|US20090286777A1_0454
3.9.24|[c:6]:[c&H0&+0&D3:5](:[s:4])-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([s:8]1)Br.Br[Mg][c:9]1[cH:10][cH:11][cH:12][s:13]1>Cl[Ni]1([P](CCC[P]1(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1)Cl.CCOCC>[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([s:8]1)-[c:9]1[cH:10][cH:11][cH:12][s:13]1|US20150108409A1_0263
1.7.12|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[C:3].[C:2]-[O&H1&+0&D1:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:1]-[C:2]|[O:1]=[C:2]([OH:3])[CH:4]1[CH2:5][CH:6]2[CH:7]=[CH:8][CH:9]1[CH2:10]2>O.O.O=S(=O)(O)O>[O:1]=[C:2]1[O:3][CH:8]2[CH2:7][CH:6]3[CH2:10][CH:9]2[CH:4]1[CH2:5]3|US10550105B2_0663
3.11.34|[C:6]-[C&H2&+0&D2:5]-[C:4].[O&H1&D1:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:2](-[O&H1&D1:3])-[c:1]|[CH3:1][CH2:2][CH2:3][c:4]1[c:5]([cH:6][cH:7][c:8]([c:9]1[OH:10])[C:11]([CH3:12])=[O:13])[O:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][c:20]([cH:21]1)[NH:22][C:23](=[O:24])[c:25]1[cH:26][cH:27][cH:28][c:29]([cH:30]1)[C:31](=O)[OH:32].[CH3:33][C:34]1([O:35][C:36]([CH2:37][C:38]([O:39]1)=[O:40])=[O:41])[CH3:42]>CN(C)c1ccncc1.ClCCl.C(=NC1CCCCC1)=NC1CCCCC1>[CH3:1][CH2:2][CH2:3][c:4]1[c:5]([cH:6][cH:7][c:8]([c:9]1[OH:10])[C:11]([CH3:12])=[O:13])[O:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][c:20]([cH:21]1)[NH:22][C:23](=[O:24])[c:25]1[cH:26][cH:27][cH:28][c:29]([cH:30]1)[C:31]([OH:32])=[C:37]1[C:38]([O:39][C:34]([O:35][C:36]1=[O:41])([CH3:33])[CH3:42])=[O:40]|US20200181150A1_0137
9.7.41|[C&H0&-&D1:5]#[N&H0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[C-:1]#[N:2].[O:3]=[C:4](Cl)[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11].[Cu+]>>[N:2]#[C:1][C:4](=[O:3])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11]|EP2024345B1_0048
7.6.1|[C:6]-[C&H0&+0&D3:5](-[O&H1&D1:4])=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[O&H1&D1:4])-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][NH:2][C:3](=[S:4])[C:5]1=[C:6]([C:7]([O:8][c:9]2[cH:10][cH:11][c:12]([cH:13][c:14]12)[C:15]#[N:16])([CH3:17])[CH2:18][CH3:19])[OH:20]>[Na+].CO.[BH4-]>[CH3:19][CH2:18][C:7]1([O:8][c:9]2[cH:10][cH:11][c:12]([cH:13][c:14]2[CH:5]([CH:6]1[OH:20])[C:3](=[S:4])[NH:2][CH3:1])[C:15]#[N:16])[CH3:17]|EP0398665A1_0134
3.7.2|[C&H3&+0&D1:5]-[#12&+].[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[Br-].[CH3:1][Mg+].[O:2]=[C:3]([c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Br:10])[CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1>O.CCOCC.C1CCOC1>[CH3:1][C:3]([OH:2])([c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Br:10])[CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1|US20150329501A1_1304
3.11.93|[C:6]-[C&H2&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][C@H:3]1[CH2:4][CH2:5][C@H:6]2[C@@H:7]3[CH2:8][CH2:9][C@H:10]4[CH2:11][C:12]([CH2:13][CH2:14][C@@:15]4([C@H:16]3[CH2:17][CH2:18][C@:19]12[CH3:20])[CH3:21])=[O:22].[O:23]=[C:24](O)[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>CC(=O)OC(C)=O.O=C(OC(=O)c1ccccc1)c1ccccc1>[CH3:1][O:2][C@H:3]1[CH2:4][CH2:5][C@H:6]2[C@@H:7]3[CH2:8][CH2:9][C@H:10]4[CH2:11][C:12]([CH:13]([CH2:14][C@@:15]4([C@H:16]3[CH2:17][CH2:18][C@:19]12[CH3:20])[CH3:21])[C:24](=[O:23])[c:25]1[cH:30][cH:29][cH:28][cH:27][cH:26]1)=[O:22]|US20190337965A1_1192
7.6.1|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:3](-[C:2])-[N:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:3](-[C:2])-[N:1]|[CH3:1][C:2]1[C:3]([C@@H:4]2[CH2:5][C:6]([N:7]2[C:8]=1[C:9](=[O:10])[O:11][CH2:12][O:13][C:14](=[O:15])[C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])=[O:21]>Cc1ccccc1.C1CCOC1.CC(=O)O.ClCCl.[Ni].[Zn]>[CH3:1][CH:2]1[C:3]([C@@H:4]2[CH2:5][C:6]([N:7]2[CH:8]1[C:9](=[O:10])[O:11][CH2:12][O:13][C:14](=[O:15])[C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])=[O:21]|US08299084B2_0213
7.6.1|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][CH2:13]1)[CH2:14][C:15]([c:16]1[cH:17][c:18]([c:19]([cH:20][c:21]12)[Cl:22])[CH3:23])=[C:24]([CH3:25])[C:26]#[N:27]>>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][CH2:13]1)[CH2:14][CH:15]([c:16]1[cH:17][c:18]([c:19]([cH:20][c:21]12)[Cl:22])[CH3:23])[CH:24]([CH3:25])[C:26]#[N:27]|US09840512B2_0860
3.11.93|[C:6]-[C&H2&+0&D2:5]-[c:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[O:1]=[C:2](O)[CH2:3][CH2:4][CH2:5][C:6](=[O:7])[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[Cl:15]>O.O=S(=O)(O)O>[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][C:6]([CH:8]1[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[Cl:15])=[O:7]|EP3288934B1_0165
9.7.73|[C:6]-[C&H0&+0&D4:5](-[C:4])(-[c:3])-O.[N&+:2]=[N&H0&+0&D2:1]-[#11]>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[c:3])-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]1([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1)O.[N-:15]=[N+:16]=[N:17][Na]>O=C(O)C(F)(F)F.ClCCl>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]1([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1)[N:17]=[N+:16]=[N-:15]|US08415310B2_0866
2.1.2|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([c:7]([nH:8][c:9]2[cH:10][cH:11]1)[CH3:12])[CH2:13][C:14](=[O:15])[O:16][CH:17]([O:18][C:19]([CH3:20])=[O:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[O:28]=[C:29](O)[c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[Cl:36]>c1ccc2cccnc2c1.CCN(CC)CC.c1ccncc1.O=C=O>[CH3:20][C:19](=[O:21])[O:18][CH:17]([O:16][C:14](=[O:15])[CH2:13][c:6]1[c:5]2[cH:4][c:3]([cH:11][cH:10][c:9]2[n:8]([c:7]1[CH3:12])[C:29](=[O:28])[c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[Cl:36])[O:2][CH3:1])[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|US05283251A
1.2.17|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[C:3].[N&H2&+0&D1:2]-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[CH:8]1[CH:9]=[CH:10][CH2:11][CH2:12][CH:13]=1>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.Cc1ccccc1.O=C(O)C(F)(F)F>[CH:13]1=[CH:8][CH:9]([CH2:10][CH2:11][CH2:12]1)[NH:1][c:2]1[cH:7][cH:6][cH:5][cH:4][cH:3]1|EP3033341B1_0141
1.7.18|[C&H3&D1:5]-[O&H1&+0&D1:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[N:1]>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[N&H1&+0&D1:3])-[N:1]|[CH2:1]=[CH:2][CH2:3][N:4]([C:5]#[N:6])[CH2:7][CH:8]=[CH2:9].[CH3:10][OH:11]>O.[C-]#N.[K+]>[CH2:1]=[CH:2][CH2:3][N:4]([CH2:7][CH:8]=[CH2:9])[C:5](=[NH:6])[O:11][CH3:10]|US09988390B2_0259
3.11.34|[C&H3&D1:6]-[C&H0&+0&D3:5](-[c:4])=O.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH3:15][CH2:16][O:17][C:18](=[O:19])[CH2:20][C:21]#[N:22]>c1ccccc1.CC([O-])=O.CC(=O)O.[NH4+].O>[CH3:15][CH2:16][O:17][C:18](=[O:19])[C:20]([C:21]#[N:22])=[C:2]([CH3:1])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US04239694A
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]-[N&H1&+0&D2:2]-[O:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[O:1]|[O:1]=[C:2](O)[CH2:3][c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[Cl:10])[Cl:11].[cH:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[C@@H:18]([CH2:19][N:20]1[CH2:21][CH2:22][C@@H:23]([CH2:24]1)[O:25][CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30][O:31]1)[NH:32][O:33][CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38][O:39]1>>[O:1]=[C:2]([CH2:3][c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[Cl:10])[Cl:11])[N:32]([O:33][CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38][O:39]1)[C@H:18]([CH2:19][N:20]1[CH2:21][CH2:22][C@@H:23]([CH2:24]1)[O:25][CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30][O:31]1)[c:15]1[cH:16][cH:17][cH:12][cH:13][cH:14]1|US05039672A
2.1.2|[C:6]-[N&H1&+0&D2:5]-[O:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:6]-[N&H0&+0&D3:5](-[O:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=[O:10])O.[CH3:11][C:12]1=[CH:13][CH:14]([NH:15][O:16][CH:17]1[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[O:24][CH3:25])[CH3:26]>CO.CCN=C=NCCCN(C)C.CC#N.CN(C)C=O.ClCCl>[CH3:25][O:24][c:21]1[cH:22][cH:23][c:18]([cH:19][cH:20]1)[CH:17]1[O:16][N:15]([CH:14]([CH:13]=[C:12]1[CH3:11])[CH3:26])[C:9](=[O:10])[c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[O:2][CH3:1]|US20180353480A1_0685
3.11.34|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=O.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][C:2](=O)[CH2:3][N:4]([C:5](=[O:6])[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[C:14]([CH3:15])([CH3:16])[c:17]1[cH:18][c:19]([cH:20][cH:21][cH:22]1)[Cl:23]>CCO.O[Na]>[CH3:1][C:2]1[CH2:3][N:4]([C:5]([C:7]=1[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)=[O:6])[C:14]([CH3:15])([CH3:16])[c:17]1[cH:22][cH:21][cH:20][c:19]([cH:18]1)[Cl:23]|US08445509B2_0995
3.11.93|[C&H3&+0&D1:5]-[C:4].[C&H3&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H2&+0&D2:5](-[C:4])-[C&H0&+0&D3:2](-[C&H3&D1:3])=[O&H0&D1:1]|[CH3:1][C:2](=[O:3])[c:4]1[c:5]([n:6][c:7]([cH:8][c:9]1[CH3:10])[CH3:11])[CH3:12].[CH3:13][C:14](=[O:15])O>O.Cc1ccccc1.CCOC(C)=O.CC(C)(C)[O-].[K+]>[CH3:13][C:14](=[O:15])[CH2:1][C:2](=[O:3])[c:4]1[c:9]([cH:8][c:7]([n:6][c:5]1[CH3:12])[CH3:11])[CH3:10]|EP2548863A1_0179
3.11.93|[C:6]-[C&H2&+0&D2:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][s:6][c:7]1[C:8](=[O:9])O.[NH2:10][C:11](=[O:12])[N:13]1[C:14]([CH2:15][c:16]2[cH:17][c:18]([cH:19][cH:20][c:21]21)[Cl:22])=[O:23]>CC(=O)O.CN(C)c1ccncc1.O=S(Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][s:6][c:7]1[C:8](=[O:9])[CH:15]1[C:14]([N:13]([c:21]2[cH:20][cH:19][c:18]([cH:17][c:16]21)[Cl:22])[C:11]([NH2:10])=[O:12])=[O:23]|EP1575956B1_0232
1.8.17|[C:6]-[S&H1&+0&D1:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C:6]-[S&H0&+0&D2:5]-[C&H1&+0&D3:2](-[c:1])-[C&H2&+0&D2:3]-[C:4]|[O:1]=[C:2]([OH:3])[CH:4]=[CH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[Cl:12].[O:13]=[C:14]([OH:15])[CH2:16][SH:17]>CCN(CC)CC.C1COCCO1.O=S(=O)(O)O>[O:13]=[C:14]([OH:15])[CH2:16][S:17][CH:5]([CH2:4][C:2](=[O:1])[OH:3])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[Cl:12]|US06710078B2
3.11.34|[C:6]-[C&H2&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](-[O&H1&D1:1])=O>>[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:2](-[C:3])-[O&H1&D1:1]|O=[C:1]([OH:2])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[N:28]#[C:29][CH2:30][C:31]#[N:32]>CC(C)COC(=O)Cl.CCN(CC)CC.ClCCl>[N:28]#[C:29][C:30]([C:31]#[N:32])=[C:1]([OH:2])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|US20100029911A1_0089
3.1.2|[c:5]:[c&H0&+0&D3:4](:[c:3])-B1-O-C(-C)(-C)-C(-C)-O-1.[c:2]-[C&H2&+0&D2:1]-Cl>>[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][CH2:2][CH2:3][CH2:4][O:5][C:6](=[O:7])[NH:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)B1OC(C(O1)(C)C)C.[CH3:15][n:16]1[cH:17][c:18]([cH:19][n:20]1)-[n:21]1[cH:22][cH:23][c:24]([c:25]([n:26]1)[CH2:27]Cl)=[O:28]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.COCCOC.[O-]C([O-])=O.O.[Na+].[Na+]>[CH3:1][CH2:2][CH2:3][CH2:4][O:5][C:6](=[O:7])[NH:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[CH2:27][c:25]1[n:26][n:21]([cH:22][cH:23][c:24]1=[O:28])-[c:18]1[cH:19][n:20][n:16]([cH:17]1)[CH3:15]|EP3440069B1_0431
2.1.2|[N&H2&+0&D1:5]-[O&H1&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[N&H1&+0&D2:5](-[O&H1&D1:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[S:9](=[O:10])(=[O:11])[N:12]1[CH:13]=[CH:14][C:15](=[CH:16][CH2:17][N:18]1[C:19](=[O:20])O)[S:21](=[O:22])(=[O:23])[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[O:30][CH3:31].[NH2:32][OH:33].Cl>O=CCCc1ccc(cc1)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO[C@@H]1OC[C@@H]([C@H]([C@@H]1O)O)O.CCN(CC)CC.CN(C)C=O.C1CCOC1.C(C#[O+])#[O+].ClCCl.NO.O.[Cl-].[Cl-].Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[S:9](=[O:10])(=[O:11])[N:12]1[CH:13]=[CH:14][C:15](=[CH:16][CH2:17][N:18]1[C:19](=[O:20])[NH:32][OH:33])[S:21](=[O:22])(=[O:23])[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[O:30][CH3:31]|US09532990B2_1270
3.11.34|[C&H3&D1:6]-[C&H0&+0&D3:5](-[c:4])=O.[C:3]-[C&H2&+0&D2:2]-[S:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:2](-[C:3])-[S:1]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[F:9])[O:10][CH2:11][CH2:12][O:13][c:14]1[c:15]([c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[n:22]([c:23]1-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30])[CH3:31])=[O:32].[O:33]=[C:34]1[CH2:35][S:36][C:37]([NH:38]1)=[O:39]>Cc1ccccc1.O=C(O)c1ccccc1.C1CCNCC1>[CH3:1][C:2](=[C:35]1[S:36][C:37]([NH:38][C:34]1=[O:33])=[O:39])[c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[F:9])[O:10][CH2:11][CH2:12][O:13][c:14]1[c:15]([c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[n:22]([c:23]1-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30])[CH3:31])=[O:32]|US09493478B2_0786
2.1.2|[N&H2&+0&D1:5]-[O&H1&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H1&+0&D2:5](-[O&H1&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][c:2]1[c:3]([cH:4][cH:5][c:6]2[c:7]3[cH:8][cH:9][cH:10][c:11]([c:12]3[nH:13][c:14]21)[C:15](=[O:16])O)[Cl:17].[NH2:18][OH:19]>[Na+].CCO.CC[O-].[Na]>[CH3:1][c:2]1[c:3]([cH:4][cH:5][c:6]2[c:14]1[nH:13][c:12]1[c:7]2[cH:8][cH:9][cH:10][c:11]1[C:15](=[O:16])[NH:18][OH:19])[Cl:17]|US20120101099A1_0252
1.7.12|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[c:3].[C:2]-[O&H1&+0&D1:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])-[c:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]=[CH:7][c:8]1[cH:9][c:10]2[O:11][CH2:12][O:13][c:14]2[cH:15][c:16]1[CH2:17][CH2:18][OH:19]>[Na+].CCO.CC[O-]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]1[O:19][CH2:18][CH2:17][c:16]2[cH:15][c:14]3[O:13][CH2:12][O:11][c:10]3[cH:9][c:8]21|US10689395B2_0281
1.7.12|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[O:3].[O&H1&+0&D1:2]-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[O:3]|[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][cH:10][c:11]2[c:12]1[S:13][c:14]1[cH:15][cH:16][c:17]([cH:18][c:19]1[N:20]2[CH2:21][CH2:22][CH2:23][Cl:24])[OH:25].[CH:26]1=[CH:27][O:28][CH2:29][CH2:30][CH2:31]1>Cl.CCO>[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][cH:10][c:11]2[c:12]1[S:13][c:14]1[cH:15][cH:16][c:17]([cH:18][c:19]1[N:20]2[CH2:21][CH2:22][CH2:23][Cl:24])[O:25][CH:27]1[CH2:26][CH2:31][CH2:30][CH2:29][O:28]1|EP3730501A1_0063
9.7.300|[N&H3&+0&D0:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[N&H2&+0&D1:5]-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[NH3:1].[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[N:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[N:22]=[C:23]=[S:24]>CO.ClCCl>[CH3:2][O:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[N:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[NH:22][C:23]([NH2:1])=[S:24]|US20150197513A1_0226
1.7.18|[C&H3&D1:5]-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[N&H1&+0&D1:1]|[ClH:1].[CH3:2][O:3][CH2:4][CH2:5][C:6]#[N:7].[CH3:8][OH:9]>Cc1ccccc1>[ClH:1].[CH3:2][O:3][CH2:4][CH2:5][C:6](=[NH:7])[O:9][CH3:8]|US20190144431A1_0231
1.7.18|[C&H3&D1:5]-[O&H1&+0&D1:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[N&H1&+0&D1:3])-[c:1]|[CH3:1][OH:2].[N:3]#[C:4][c:5]1[cH:6][cH:7][c:8]([o:9]1)-[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[N+:16]([O-:17])=[O:18]>[Na+].C[O-]>[CH3:1][O:2][C:4](=[NH:3])[c:5]1[cH:6][cH:7][c:8]([o:9]1)-[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[N+:16]([O-:17])=[O:18]|EP2953470B1_0218
3.5.3|[C:6]-[C&H1&+0&D3:5](-[C:4])-[#30]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([NH:3][C@@:4]([CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)([c:12]1[cH:13][c:14]([cH:15][c:16]([cH:17]1)[O:18][C:19]([F:20])([F:21])[CH:22]([F:23])[F:24])[F:25])[c:26]1[cH:27][cH:28][c:29]([c:30]([cH:31]1)Br)[F:32])[c:33]1[cH:34][cH:35][c:36]([c:37]([cH:38]1)[C:39]([F:40])([F:41])[F:42])[F:43].Br[Zn][CH:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1>C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.c1cc[c-](c1)P(c1ccccc1)c1ccccc1.c1cc[c-](c1)P(c1ccccc1)c1ccccc1.C1CCOC1.ClCl.[Fe+2].[Pd]>[O:1]=[C:2]([NH:3][C@@:4]([CH2:5][c:6]1[cH:11][cH:10][cH:9][cH:8][cH:7]1)([c:12]1[cH:17][c:16]([cH:15][c:14]([cH:13]1)[F:25])[O:18][C:19]([F:20])([F:21])[CH:22]([F:23])[F:24])[c:26]1[cH:27][cH:28][c:29]([c:30]([cH:31]1)[CH:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1)[F:32])[c:33]1[cH:34][cH:35][c:36]([c:37]([cH:38]1)[C:39]([F:40])([F:41])[F:42])[F:43]|US20200087304A1_0749
3.7.2|[C&H3&+0&D1:5]-[#12&+].[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[O:1]=[C:2]1[CH:3]2[CH2:4][CH:5]3[CH2:6][CH:7]([CH2:8][CH:9]1[CH2:10]3)[CH2:11]2.[CH3:12][Mg+].[Br-]>CCOCC>[CH3:12][C:2]1([CH:9]2[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:11][CH:3]1[CH2:4]3)[CH2:8]2)[OH:1]|EP0701444B1_0100
3.9.55|[c:5]:[c&H1&+0&D2:4]:[c:3].[O&H0&+0&D2:2](-[C&H1&+0&D3:1](-Cl)-Cl)-C>>[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H1&+0&D2:1]=[O&H0&+0&D1:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[CH2:8][N:9]([CH2:10][CH2:11][c:12]12)[CH3:13].C[O:14][CH:15](Cl)Cl>Cl[Ti](Cl)(Cl)Cl.ClCCl.O[Na].O>[CH3:13][N:9]1[CH2:10][CH2:11][c:12]2[c:3]([cH:4][cH:5][c:6]([c:7]2[CH2:8]1)[CH:15]=[O:14])[O:2][CH3:1]|US05089654A
1.3.9|[C:6]-[N&H1&+0&D2:5]-[N&H2&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]-[N&H0&+0&D3:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|I[c:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)-[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.[CH3:13][C:14]([CH3:15])([CH3:16])[O:17][C:18](=[O:19])[NH:20][NH2:21]>c1ccc2ccc3cccnc3c2n1.C1COCCO1.[O-]C([O-])=O.I[Cu].[Cs+].[Cs+]>[CH3:13][C:14]([CH3:15])([CH3:16])[O:17][C:18](=[O:19])[N:20]([NH2:21])[c:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)-[c:7]1[cH:12][cH:11][cH:10][cH:9][cH:8]1|US20090253687A1_2297
1.3.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([NH:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)I.[CH3:17][NH:18][CH:19]=[O:20]>CCCCCCCCCCCC.N[C@@H]1CCCC[C@H]1N.C1COCCO1.[O-]P([O-])([O-])=O.I[Cu].[K+].[K+].[K+]>[CH3:17][N:18]([CH:19]=[O:20])[c:14]1[cH:13][cH:12][c:11]([cH:16][cH:15]1)[C:2](=[O:1])[NH:3][CH2:4][c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1|US20130023563A1_0176
1.2.5|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][CH2:3][CH2:4][C:5](=[O:6])[NH:7][C:8]([CH3:9])([CH3:10])[CH2:11][C:12]([CH3:13])=O.[CH2:14]1[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]1>C[NH2+]C.[O-][Cl](=O)(=O)=O.[O-2].[Pt+2]>[CH3:1][O:2][CH2:3][CH2:4][C:5](=[O:6])[NH:7][C:8]([CH3:9])([CH3:10])[CH2:11][CH:12]([CH3:13])[N:17]1[CH2:16][CH2:15][CH2:14][CH2:19][CH2:18]1|EP3512837B1_0150
1.2.5|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:12][CH2:13]1)=O.[CH3:14][NH:15][c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[C:22]([F:23])([F:24])[F:25]>CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(=O)O.ClCCCl.[Na+]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[N:15]([CH3:14])[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[C:22]([F:23])([F:24])[F:25]|US09718838B2_0343
2.1.3|[N&H2&+0&D1:5]-[N&H2&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|O.[NH2:1][NH2:2].[O-:3][N+:4](=[O:5])[c:6]1[cH:7][c:8]([cH:9][cH:10][cH:11]1)[C:12](=[O:13])O>Cl.CO>[NH2:2][NH:1][C:12](=[O:13])[c:8]1[cH:9][cH:10][cH:11][c:6]([cH:7]1)[N+:4]([O-:3])=[O:5]|US04703120A
1.3.8|[C&H3&D1:6]-[N&H1&+0&D2:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][S:2](=[O:3])(=[O:4])[NH:5][CH3:6].[O-:7][N+:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1F>O.C[O-].CN(C)C=O.[K+]>[CH3:6][N:5]([c:15]1[cH:14][cH:13][cH:12][cH:11][c:10]1[N+:8]([O-:7])=[O:9])[S:2]([CH3:1])(=[O:3])=[O:4]|US10023590B2_0528
3.5.2|[c:6]:[c&H0&+0&D3:5](:[c:4])-[#12]-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[Mg]Br.[F:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1Br>>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:14]1[cH:13][cH:12][cH:11][cH:10][c:9]1[F:8]|US20190135961A1_0094
3.11.91|[C&H3&D1:6]-[C&H2&+0&D2:5]-I.[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C&H3&D1:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:7][CH2:8][CH2:9][C:10]1=[O:11].[CH3:12][CH2:13]I>[NaH]>[CH3:12][CH2:13][C:6]1([CH2:7][CH2:8][CH2:9][C:10]1=[O:11])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US08829007B2_2308
1.2.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[n:3][n:4]([c:5]2[n:6][c:7]([c:8]([cH:9][c:10]12)[C:11]#[N:12])O)[CH3:13].[CH3:14][N:15]([CH3:16])[CH2:17][CH2:18][NH:19][CH3:20]>O=P(Cl)(Cl)c1ccccc1>[CH3:20][N:19]([CH2:18][CH2:17][N:15]([CH3:14])[CH3:16])[c:7]1[n:6][c:5]2[c:10]([cH:9][c:8]1[C:11]#[N:12])[c:2]([n:3][n:4]2[CH3:13])[CH3:1]|US20190263805A1_1033
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH:1]1=[CH:2][c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[NH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]12.[O:16]=[C:17](O)[C:18]([F:19])([F:20])[F:21]>O=C(OC(=O)C(F)(F)F)C(F)(F)F.CCN(CC)CC.c1ccccc1.O>[O:16]=[C:17]([N:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[CH:1]=[CH:2][c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]21)[C:18]([F:19])([F:20])[F:21]|US09586958B2_0722
9.7.259|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[N:3].[N&H2&+0&D1:2]-[O&H1&D1:1]>>[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[O&H1&D1:1])-[N:3]|[ClH:1].[N:2]#[C:3][NH:4][c:5]1[c:6]([cH:7][cH:8][cH:9][c:10]1[Cl:11])[Cl:12].[NH2:13][OH:14]>[Na+].CO.C[O-]>[ClH:1].[NH:2]=[C:3]([NH:13][OH:14])[NH:4][c:5]1[c:10]([cH:9][cH:8][cH:7][c:6]1[Cl:12])[Cl:11]|US20130184257A1_0577
9.7.259|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3].[N&H2&+0&D1:2]-[O&H1&D1:1]>>[N&H2&+0&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[O&H1&D1:1])-[c:3]|Cl.[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([o:7]1)-[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14].[NH2:15][OH:16]>CCO.O[K]>[NH2:1][C:2](=[N:15][OH:16])[c:3]1[cH:4][cH:5][c:6]([o:7]1)-[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14]|US08399451B2_0408
9.7.259|[C:5]-[C&H0&+0&D2:4]#[N&H0&+0&D1:3].[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C:5]-[C&H0&+0&D3:4](=[N&H1&+0&D1:3])-[N&H1&+0&D2:2]-[O&H1&D1:1]|Cl.[N:1]#[C:2][CH2:3][S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[Cl:13].[NH2:14][OH:15]>O.[Na+].[Na+].CCO.[O-]C([O-])=O>[NH:1]=[C:2]([CH2:3][S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[Cl:13])[NH:14][OH:15]|EP3431474A1_0313
9.7.259|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[N:3].[N&H2&+0&D1:2]-[O&H1&D1:1]>>[N&H2&+0&D1:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[O&H1&D1:1])-[N:3]|Cl.[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([CH3:7])[CH:8]([CH3:9])[c:10]1[cH:11][c:12]([c:13]2[C:14]3[CH2:15][N:16]([CH2:17][CH2:18][C:19]=3[C:20]([O:21][c:22]2[cH:23]1)([CH3:24])[CH3:25])[C:26]#[N:27])[OH:28].[NH2:29][OH:30]>CN(C)C=O.O=C(O[Na])O[Na]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([CH3:7])[CH:8]([CH3:9])[c:10]1[cH:11][c:12]([c:13]2[C:14]3[CH2:15][N:16]([CH2:17][CH2:18][C:19]=3[C:20]([O:21][c:22]2[cH:23]1)([CH3:24])[CH3:25])[C:26]([NH2:27])=[N:29][OH:30])[OH:28]|US09163023B2_0380
1.2.5|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|Cl.[CH3:1][NH:2][CH2:3][C:4](=[O:5])[OH:6].O=[C:7]1[CH2:8][CH2:9][CH2:10][CH:11]2[CH2:12][CH2:13][CH2:14][CH2:15][CH:16]12>CO.CC([O-])=O.c1ccsc1.[H][H].[K+].[Pd]>[CH3:1][N:2]([CH2:3][C:4](=[O:5])[OH:6])[CH:7]1[CH2:8][CH2:9][CH2:10][CH:11]2[CH2:12][CH2:13][CH2:14][CH2:15][CH:16]21|EP2049477B1_0150
3.11.34|[C:6]-[C&H2&+0&D2:5]-[c:4].[O&H1&D1:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:6]-[C&H0&+0&D3:5](-[c:4])=[C&H0&+0&D3:2](-[O&H1&D1:3])-[c:1]|[CH3:1][C:2](=[O:3])[N:4]1[C:5]([CH2:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]21)[N+:13]([O-:14])=[O:15])=[O:16].O=[C:17]([OH:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[C:25]([F:26])([F:27])[F:28]>CN(C)C(On1nnc2ccccc21)=[N+](C)C.On1nnc2ccccc21.CN(C)C=O.F[B-](F)(F)F.Cl>[CH3:1][C:2](=[O:3])[N:4]1[C:5]([C:6]([c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]21)[N+:13]([O-:14])=[O:15])=[C:17]([OH:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[C:25]([F:26])([F:27])[F:28])=[O:16]|US20070004757A1_0257
1.2.9|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][N:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1.[CH3:8][CH:9](O)[C:10]#[N:11]>c1ccccc1.O>[CH3:8][CH:9]([C:10]#[N:11])[N:5]1[CH2:4][CH2:3][N:2]([CH2:7][CH2:6]1)[CH3:1]|US07256289B2_0056
2.5.5|[C&H3&D1:5]-[C&H0&+0&D2:4]#[N&H0&+0&D1:3].[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[N&H1&+0&D1:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[NH2:8])[N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1.[CH3:15][C:16]#[N:17]>Cl[Al](Cl)Cl>[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[NH:8][C:16]([CH3:15])=[NH:17])[N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1|US20130143929A1_0268
1.2.9|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH:3]([CH3:4])O.[Cl:5][c:6]1[n:7][c:8]([c:9]2[n:10][cH:11][nH:12][c:13]2[n:14]1)[Cl:15]>>[CH3:1][CH2:2][CH:3]([CH3:4])[n:12]1[cH:11][n:10][c:9]2[c:8]([n:7][c:6]([n:14][c:13]21)[Cl:5])[Cl:15]|US10428072B2_0471
3.11.91|[C&H3&D1:6]-[C&H2&+0&D2:5]-I.[C:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[C&H3&D1:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH:7]([C:8]([c:9]2[c:10]([c:11]1[Cl:12])[Cl:13])=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[CH3:21][CH2:22]I>c1ccccc1.CN(C)C=O.C[O-].O.[Na+]>[CH3:21][CH2:22][C:7]1([CH2:6][c:5]2[cH:4][c:3]([c:11]([c:10]([c:9]2[C:8]1=[O:14])[Cl:13])[Cl:12])[O:2][CH3:1])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20180244611A1_1122
1.2.9|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2](O)[c:3]1[cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][cH:11][c:12]-21.[O:13]=[C:14]1[NH:15][C:16]([c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]12)=[O:23]>CCCCP(CCCC)CCCC.CN(C)C(=O)N=NC(=O)N(C)C.C1CCOC1>[CH3:1][CH:2]([c:3]1[cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][cH:11][c:12]-21)[N:15]1[C:14]([c:22]2[cH:21][cH:20][cH:19][cH:18][c:17]2[C:16]1=[O:23])=[O:13]|US10246453B2_1743
2.1.2|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][c:8]([c:9]2[nH:10][c:11]([cH:12][c:13]2[cH:14]1)[C:15](=[O:16])[O:17][CH2:18][CH3:19])[N+:20]([O-:21])=[O:22].[CH3:23][C:24]([CH3:25])([CH3:26])[O:27][C:28](=[O:29])O>CN(C)c1ccncc1.CCOC(C)=O.C1CCOC1.O>[CH3:1][O:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][c:8]([c:9]2[c:13]([cH:14]1)[cH:12][c:11]([n:10]2[C:28](=[O:29])[O:27][C:24]([CH3:23])([CH3:25])[CH3:26])[C:15](=[O:16])[O:17][CH2:18][CH3:19])[N+:20]([O-:21])=[O:22]|EP3643703A1_0216
2.4.5|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][CH:2]([Cl:3])[O:4][C:5](=[O:6])Cl.[OH:7][c:8]1[cH:9][c:10]2[S:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[NH:18][c:19]2[c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]12>C1CCOC1>[CH3:1][CH:2]([Cl:3])[O:4][C:5](=[O:6])[N:18]1[c:19]2[c:10]([cH:9][c:8]([c:25]3[cH:24][cH:23][cH:22][cH:21][c:20]32)[OH:7])[S:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21|US20110245242A1_0483
3.11.93|[C:6]-[C&H2&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][c:6]2[o:7][c:8]3[n:9][cH:10][cH:11][cH:12][c:13]3[c:14]([c:15]2[cH:16]1)=[O:17].[CH3:18][CH2:19][O:20][C:21](=[O:22])[CH2:23][C:24](=[O:25])[O:26][CH2:27][CH3:28]>Clc1ccccc1.O=S(=O)(O)O.ClC(Cl)(Cl)Cl.CCO.O.[Mg]>[CH3:28][CH2:27][O:26][C:24](=[O:25])[CH:23]([C:21](=[O:22])[O:20][CH2:19][CH3:18])[C:2](=[O:1])[c:3]1[cH:4][cH:5][c:6]2[o:7][c:8]3[n:9][cH:10][cH:11][cH:12][c:13]3[c:14]([c:15]2[cH:16]1)=[O:17]|US20200308157A1_0455
3.11.93|[C:6]-[C&H2&+0&D2:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH2:1][C:2](=[O:3])[N:4]1[C:5]([CH2:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]21)[Cl:13])=[O:14].[O:15]=[C:16](Cl)[c:17]1[cH:18][cH:19][cH:20][s:21]1>O.Cl.CN(C)c1ccncc1.CN(C)C=O>[NH2:1][C:2](=[O:3])[N:4]1[C:5]([CH:6]([c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]21)[Cl:13])[C:16](=[O:15])[c:17]1[cH:18][cH:19][cH:20][s:21]1)=[O:14]|EP2802569B1_0075
3.5.3|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#30&+]>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][c:9]1[c:10]([cH:11][c:12]([cH:13][c:14]1[CH3:15])Br)[CH3:16].[CH2:17]1[CH2:18][CH:19]1[Zn+].[Cl-]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1CCOC1.O=[Si]=O>[CH3:16][c:10]1[cH:11][c:12]([cH:13][c:14]([c:9]1[O:8][Si:5]([CH3:6])([CH3:7])[C:2]([CH3:1])([CH3:3])[CH3:4])[CH3:15])[CH:19]1[CH2:17][CH2:18]1|US10272094B2_0945
2.1.1|[C:6]-[N&H1&+0&D2:5]-[S:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[S:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[F:9].[O:10]=[C:11]1[NH:12][S:13]([c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]12)(=[O:20])=[O:21].[Na]>C1CCOC1>[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[F:9])[N:12]1[C:11]([c:19]2[cH:18][cH:17][cH:16][cH:15][c:14]2[S:13]1(=[O:20])=[O:21])=[O:10]|US20200115357A1_0420
1.6.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Br)[C:7](=[O:8])[O:9][CH2:10][CH3:11].[CH3:12][NH:13][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1>CCN(CC)CC.Cc1ccccc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[N:13]([CH3:12])[CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1|US20190076539A1_0762
2.1.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[NH:5][C:6]1=[N:7][c:8]2[cH:9][cH:10][c:11]([cH:12][c:13]2[NH:14][S:15]1=[O:16])[O:17][S:18](=[O:19])(=[O:20])[c:21]1[cH:22][c:23]([cH:24][cH:25][cH:26]1)[C:27]([F:28])([F:29])[F:30].[O:31]=[C:32](Cl)[c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1>CC(=O)OCC.c1ccncc1.O>[CH3:1][O:2][C:3](=[O:4])[NH:5][C:6]1=[N:7][c:8]2[cH:9][cH:10][c:11]([cH:12][c:13]2[N:14]([S:15]1=[O:16])[C:32](=[O:31])[c:33]1[cH:38][cH:37][cH:36][cH:35][cH:34]1)[O:17][S:18](=[O:19])(=[O:20])[c:21]1[cH:26][cH:25][cH:24][c:23]([cH:22]1)[C:27]([F:28])([F:29])[F:30]|US20200147088A1_0231
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][c:4]1[cH:5][c:6]2[n:7][cH:8][c:9]([c:10]([c:11]2[cH:12][c:13]1[O:14][CH2:15][CH3:16])Cl)[C:17]#[N:18].[CH3:19][NH:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>>[CH3:16][CH2:15][O:14][c:13]1[cH:12][c:11]2[c:6]([cH:5][c:4]1[O:3][CH2:2][CH3:1])[n:7][cH:8][c:9]([c:10]2[N:20]([CH3:19])[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[C:17]#[N:18]|EP1581467B1_0069
3.7.2|[C&H3&+0&D1:5]-[#12]-Br.[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[O&H1&+0&D1:4])(-[c:2])-[c:1]|[CH3:1][Mg]Br.[NH2:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[Cl:17]>O.CCOCC>[CH3:1][C:9]([OH:10])([c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1)[c:8]1[cH:7][c:6]([cH:5][cH:4][c:3]1[NH2:2])[Cl:17]|US20200206225A1_0348
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][NH:2][CH2:3][CH2:4][OH:5].[O:6]=[S:7]1[CH2:8][CH2:9][N:10]([CH2:11][CH2:12]1)[c:13]1[n:14][c:15]([n:16][c:17]2[c:18]([n:19][cH:20][n:21][c:22]21)[NH:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)Cl>C1COCCO1>[CH3:1][N:2]([CH2:3][CH2:4][OH:5])[c:15]1[n:16][c:17]2[c:18]([n:19][cH:20][n:21][c:22]2[c:13]([n:14]1)[N:10]1[CH2:11][CH2:12][S:7]([CH2:8][CH2:9]1)=[O:6])[NH:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1|EP3683222A1_3298
3.7.2|[C&H3&+0&D1:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:7])[CH:8]=[CH:9][CH:10]1[CH2:11][CH2:12][C:13]([N:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28].[CH3:29][Mg]Br>CCOCC.CC(=O)O.O>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([CH3:29])([OH:7])[CH:8]=[CH:9][CH:10]1[CH2:11][CH2:12][C:13]([N:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28]|US20200392177A1_0381
1.2.17|[C&H1&+0&D1:6]#[C&H0&+0&D2:5]-[c:4]:[c:3]-[N&H1&+0&D2:2]-[C:1]>>[c&H1&+0&D2:6]1:[c&H1&+0&D2:5]:[c:4]:[c:3]:[n&H0&+0&D3:2]:1-[C:1]|[CH:1]#[C:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[NH:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[CH2:17][CH2:18][S:19](=[O:20])(=[O:21])[NH:22][CH3:23]>O.CCCCCCC.CN1CCCC1=O.CC(C)(C)O[K]>[CH3:23][NH:22][S:19](=[O:20])(=[O:21])[CH2:18][CH2:17][c:5]1[cH:6][cH:7][c:8]2[c:3]([cH:2][cH:1][n:9]2[CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)[cH:4]1|US20110207704A1_0920
2.1.1|[C:6]-[N&H1&+0&D2:5]-[O:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[O:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][NH:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[C:12](=[O:13])[C:14]([CH3:15])([CH3:16])[CH3:17].[CH3:18][C:19]([CH3:20])([CH3:21])[C:22](=[O:23])[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[C:30](=[O:31])Cl>Cc1ccccc1.[LiH]>[CH3:15][C:14]([CH3:16])([CH3:17])[C:12](=[O:13])[c:9]1[cH:8][cH:7][c:6]([cH:11][cH:10]1)[C:4](=[O:5])[N:3]([O:2][CH3:1])[C:30](=[O:31])[c:27]1[cH:26][cH:25][c:24]([cH:29][cH:28]1)[C:22](=[O:23])[C:19]([CH3:18])([CH3:20])[CH3:21]|EP2488501B1_0081
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][CH2:3][C:4]1([CH2:5][CH2:6][NH:7][CH2:8][CH2:9]1)[N:10]([C:11](=[O:12])[CH2:13][CH3:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[CH3:21][CH:22](Br)[C:23](=[O:24])[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>CC(=O)CC(C)C.CC(C)NC(C)C>[CH3:1][O:2][CH2:3][C:4]1([CH2:9][CH2:8][N:7]([CH2:6][CH2:5]1)[CH:22]([CH3:21])[C:23](=[O:24])[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[N:10]([C:11](=[O:12])[CH2:13][CH3:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US10376513B2_1143
2.4.5|[C:6]-[N&H1&+0&D2:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]1([CH2:6][CH2:7][N:8]([CH2:9][CH2:10]1)[C:11](=[O:12])[O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[NH:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[CH3:28][CH2:29][O:30][C:31](=[O:32])Cl>>[CH3:28][CH2:29][O:30][C:31](=[O:32])[N:21]([c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[C:5]1([CH2:6][CH2:7][N:8]([CH2:9][CH2:10]1)[C:11](=[O:12])[O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[C:3](=[O:4])[O:2][CH3:1]|US09422281B2_2068
2.4.5|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[c:2]1[nH:3][nH:4][c:5]([n:6]1-[c:7]1[cH:8][c:9]([cH:10][c:11]([cH:12]1)[Cl:13])[Cl:14])=[O:15].[CH3:16][CH2:17][O:18][C:19](=[O:20])Cl>CCN(CC)CC.CN(C)C=O.O>[CH3:16][CH2:17][O:18][C:19](=[O:20])[n:4]1[nH:3][c:2]([n:6]([c:5]1=[O:15])-[c:7]1[cH:12][c:11]([cH:10][c:9]([cH:8]1)[Cl:14])[Cl:13])=[O:1]|EP3643703A1_0198
1.2.14|[C&H3&D1:5]-[N&H2&+0&D1:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[ClH:1].[CH3:2][NH2:3].[cH:4]1[cH:5][c:6]2[c:7]([c:8]([cH:9]1)[O:10][CH2:11][CH:12]1[CH2:13][O:14]1)[CH:15]1[CH2:16][CH2:17][CH:18]2[c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]21>CC(C)O>[ClH:1].[CH3:2][NH:3][CH2:13][CH:12]([OH:14])[CH2:11][O:10][c:8]1[cH:9][cH:4][cH:5][c:6]2[c:7]1[CH:15]1[CH2:16][CH2:17][CH:18]2[c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]21|US20120122843A1_0361
3.10.1|[C:6]=[C&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:6]=[C&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[O:1]=[C:2]1[CH:3]=[C:4]([CH2:5][CH:6]([CH2:7]1)[c:8]1[cH:9][cH:10][cH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)[OH:18].[CH3:19][CH2:20][C:21](=[O:22])Cl>Cl[Sn](Cl)(Cl)Cl.ClCCCl>[CH3:19][CH2:20][C:21](=[O:22])[C:3]1=[C:4]([CH2:5][CH:6]([CH2:7][C:2]1=[O:1])[c:8]1[cH:9][cH:10][cH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)[OH:18]|US20120264735A1_1939
3.7.3|[C&H3&+0&D1:5]-[#12]-Cl.[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[O&H1&+0&D1:4])(-[c:2])-[c:1]|[CH3:1][CH:2]([CH3:3])[S:4](=[O:5])(=[O:6])[n:7]1[c:8]([n:9][c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]21)[C:16](=[O:17])[c:18]1[cH:19][c:20]([cH:21][cH:22][c:23]1[F:24])[F:25])[NH2:26].[CH3:27][Mg]Cl>C1CCOC1>[CH3:1][CH:2]([CH3:3])[S:4](=[O:5])(=[O:6])[n:7]1[c:8]([n:9][c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]21)[C:16]([CH3:27])([OH:17])[c:18]1[cH:19][c:20]([cH:21][cH:22][c:23]1[F:24])[F:25])[NH2:26]|US20100093756A1_0209
3.7.3|[C&H3&+0&D1:5]-[#12]-Cl.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17]([F:18])([F:19])[F:20].[CH3:21][Mg]Cl>CCOCC.[NH4+].[Cl-]>[CH3:21][C:2]([OH:1])([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][CH2:10][c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1)[C:17]([F:18])([F:19])[F:20]|US20170362210A1_0466
2.6.14|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O-c1:c:c:c:c:c:1.[C:2]-[O&H1&+0&D1:1]>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH:2]([CH2:3][C:4](=[O:5])Oc1ccccc1)[NH:6][C:7]([NH2:8])=[O:9].[CH2:10]=[C:11]([CH3:12])[C:13](=[O:14])[O:15][CH2:16][CH2:17][OH:18]>CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O.CCCC[Sn+2]CCCC.C1COCCO1.CCOCC>[CH2:10]=[C:11]([CH3:12])[C:13](=[O:14])[O:15][CH2:16][CH2:17][O:18][C:4](=[O:5])[CH2:3][CH:2]([CH3:1])[NH:6][C:7]([NH2:8])=[O:9]|US20150291613A1_0255
3.10.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[n:6][cH:7][n:8]([c:9]2[cH:10][c:11]1[O:12][CH3:13])[S:14](=[O:15])(=[O:16])[N:17]([CH3:18])[CH3:19].[CH3:20][CH2:21][O:22][C:23](=[O:24])Cl>CCCCCC.CCCC[Li].C1CCOC1>[CH3:20][CH2:21][O:22][C:23](=[O:24])[c:7]1[n:6][c:5]2[cH:4][c:3]([c:11]([cH:10][c:9]2[n:8]1[S:14](=[O:15])(=[O:16])[N:17]([CH3:18])[CH3:19])[O:12][CH3:13])[O:2][CH3:1]|EP3497101B1_0306
2.1.1|[N:6]-[N&H1&+0&D2:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH2:1][C:2](=[O:3])[NH:4][NH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1.[O:12]=[C:13](Cl)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>CCN(CC)CC.CC#N>[NH2:1][C:2](=[O:3])[NH:4][N:5]([C:13](=[O:12])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1|US20050234244A1_2719
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[O:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|Cl[c:1]1[n:2][c:3]([n:4][c:5]([n:6]1)[NH:7][CH:8]1[CH2:9][CH2:10]1)[NH:11][CH:12]1[CH2:13][CH2:14]1.[CH3:15][NH:16][O:17][CH3:18].[ClH:19]>CC(C)N(CC)C(C)C>[CH3:18][O:17][N:16]([CH3:15])[c:1]1[n:6][c:5]([n:4][c:3]([n:2]1)[NH:11][CH:12]1[CH2:13][CH2:14]1)[NH:7][CH:8]1[CH2:9][CH2:10]1.[ClH:19]|US20150291597A1_0670
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH2:1]=[CH:2][CH2:3][O:4][CH2:5][CH:6]([OH:7])[CH2:8][NH:9][CH2:10][CH2:11][CH3:12].[O:13]=[C:14](Cl)[CH2:15][Cl:16]>CCN(CC)CC.ClCCl>[CH2:1]=[CH:2][CH2:3][O:4][CH2:5][CH:6]([OH:7])[CH2:8][N:9]([CH2:10][CH2:11][CH3:12])[C:14](=[O:13])[CH2:15][Cl:16]|US05756784A
3.11.91|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[N:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C:4])(-[N:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][N:2]([CH3:3])[CH:4]([CH3:5])[C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[F:14].Br[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>O.O.CC(=O)N(C)C>[CH3:1][N:2]([CH3:3])[C:4]([CH3:5])([CH2:15][c:16]1[cH:21][cH:20][cH:19][cH:18][cH:17]1)[C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[F:14]|US20170002025A1_0700
1.3.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)Br.[CH3:9][NH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.Cc1ccccc1.[Pd]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[N:10]([CH3:9])[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US20200352898A1_0783
1.6.4|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[nH:15][c:16]1[CH3:17].[CH3:18][C:19](=[O:20])[CH:21]([CH3:22])Cl>O=C(O[Cs])O[Cs].CC#N.I[K]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[n:15]([c:16]1[CH3:17])[CH:21]([CH3:22])[C:19]([CH3:18])=[O:20]|US07572820B2_1546
2.1.10|[O&H0&D1:6]=[C&H0&+0&D3:5](-[C:4]-[C:3]-[N&H1&+0&D2:2]-[c:1])-O-C>>[O&H0&D1:6]=[C&H0&+0&D3:5]1-[C:4]-[C:3]-[N&H0&+0&D3:2]-1-[c:1]|CO[C:1](=[O:2])[CH:3]([CH2:4][CH2:5][CH:6]([O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21])[CH:22]([NH:23][c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30])[c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[O:37][CH2:38][c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1>C[Si](C)(C)[N-][Si](C)(C)C.CCOC(C)=O.C1CCOC1.Cl.[Li+]>[O:2]=[C:1]1[CH:3]([CH:22]([N:23]1[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30])[c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[O:37][CH2:38][c:39]1[cH:44][cH:43][cH:42][cH:41][cH:40]1)[CH2:4][CH2:5][CH:6]([O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21]|EP3438105A1_0063
1.3.6|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][O:2][CH2:3][CH2:4][NH:5][CH3:6].Br[c:7]1[n:8][n:9][c:10]([n:11]1-[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Br:18])-[c:19]1[cH:20][n:21][c:22]([cH:23][cH:24]1)-[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>ClC(Cl)Cl>[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH3:6])[c:7]1[n:8][n:9][c:10]([n:11]1-[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Br:18])-[c:19]1[cH:24][cH:23][c:22]([n:21][cH:20]1)-[c:25]1[cH:30][cH:29][cH:28][cH:27][cH:26]1|US20170275279A1_0424
2.6.1|[Cl&H0&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[Cl&H0&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[O:1]=[C:2]([Cl:3])Cl.[OH:4][c:5]1[cH:6][c:7]([c:8]([cH:9][c:10]1[Cl:11])[Cl:12])[Cl:13]>Cc1ccccc1.CN(C)c1ccccc1.CC(C)(C)OC(=O)Oc1cc(c(cc1Cl)Cl)Cl>[O:1]=[C:2]([Cl:3])[O:4][c:5]1[cH:6][c:7]([c:8]([cH:9][c:10]1[Cl:11])[Cl:12])[Cl:13]|US20080269102A1_0102
9.7.262|[C&H0&-&D1:5]#[N&H0&D1:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[O:1]=[CH:2][c:3]1[cH:4][s:5][c:6]([n:7]1)[NH:8][C:9](=[O:10])[O:11][CH2:12][C:13]([Cl:14])([Cl:15])[Cl:16].[C-:17]#[N:18].[K+]>CN(C)C=O.[O-]P(=O)(O)O.O.[K+]>[N:18]#[C:17][CH:2]([OH:1])[c:3]1[cH:4][s:5][c:6]([n:7]1)[NH:8][C:9](=[O:10])[O:11][CH2:12][C:13]([Cl:14])([Cl:15])[Cl:16]|US20190284182A1_1549
4.1.13|[C&H3&+0&D1:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[N&H0&+0&D2:1](=O)-O-[#11]>>[c&H1&+0&D2:5]1:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c:3]:[c:4]:1|[CH3:1][c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[C:8]#[N:9])[CH3:10])[NH2:11].O=[N:12]O[Na]>O.CC(=O)O>[CH3:1][c:2]1[cH:3][c:4]2[nH:11][n:12][cH:10][c:5]2[cH:6][c:7]1[C:8]#[N:9]|US20200239467A1_1038
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[N:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[N:3])-[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[N:9]=[N:10][NH:11][c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[C:18]#[N:19])[C:20]([F:21])([F:22])[F:23])[C:24]([F:25])([F:26])[F:27].[O:28]=[C:29](Cl)[CH2:30][Cl:31]>CCOCC.[NaH]>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[N:9]=[N:10][N:11]([C:29](=[O:28])[CH2:30][Cl:31])[c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[C:18]#[N:19])[C:20]([F:21])([F:22])[F:23])[C:24]([F:25])([F:26])[F:27]|US09718841B2_0375
3.10.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[NH2:9][C:10](=[O:11])[c:12]1[n:13][cH:14][nH:15][n:16]1>CCN(CC)CC.CCOCC>[NH2:9][C:10](=[O:11])[c:12]1[n:16][nH:15][c:14]([n:13]1)[C:2](=[O:1])[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|EP1537112B1_0269
3.9.60|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#30&+]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][Si:2]([CH3:3])([CH3:4])[C:5]#[C:6][c:7]1[cH:8][n:9]([c:10]([n:11]1)[CH3:12])-[c:13]1[cH:14][cH:15][c:16]([n:17][cH:18]1)Cl.[CH2:19]1[CH2:20][CH:21]1[Zn+].[Cl-]>O=C(O)O[Na].C1CCOC1>[CH3:12][c:10]1[n:11][c:7]([cH:8][n:9]1-[c:13]1[cH:14][cH:15][c:16]([n:17][cH:18]1)[CH:21]1[CH2:19][CH2:20]1)[C:6]#[C:5][Si:2]([CH3:1])([CH3:3])[CH3:4]|US20190343838A1_0437
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[F:9][C:10]([F:11])([F:12])[c:13]1[cH:14][cH:15][c:16]2[c:17]([cH:18]1)[n:19][cH:20][n:21][c:22]2Cl>CCO>[CH3:1][N:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:22]1[n:21][cH:20][n:19][c:17]2[cH:18][c:13]([cH:14][cH:15][c:16]21)[C:10]([F:9])([F:11])[F:12]|US20170114025A1_0694
3.10.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[O:1]=[C:2](Cl)[C:3]12[CH2:4][CH:5]3[CH2:6][CH:7]([CH2:8][CH:9]([CH2:10]3)[CH2:11]1)[CH2:12]2.[NH2:13][C:14](=[O:15])[c:16]1[n:17][nH:18][cH:19][n:20]1>CCN(CC)CC.CCOCC>[NH2:13][C:14](=[O:15])[c:16]1[n:17][nH:18][c:19]([n:20]1)[C:2](=[O:1])[C:3]12[CH2:4][CH:5]3[CH2:6][CH:7]([CH2:8][CH:9]([CH2:10]3)[CH2:11]1)[CH2:12]2|EP2518054A1_0295
2.3.9|[N:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[N:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][N:4]([C:5](=[O:6])Cl)[c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[Cl:13].[cH:14]1[cH:15][nH:16][cH:17][n:18]1>CCN(CC)CC.C1CCOC1.O>[CH3:1][CH2:2][CH2:3][N:4]([C:5](=[O:6])[n:16]1[cH:17][n:18][cH:14][cH:15]1)[c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[Cl:13]|US20200369664A1_0180
2.4.5|[C:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH2:2][NH:3][CH2:4][CH2:5][c:6]1[cH:7][cH:8][n:9][cH:10][cH:11]1.[CH3:12][CH2:13][O:14][C:15](=[O:16])Cl>CCN(CC)CC.ClC(Cl)Cl.O[Na].O>[CH3:1][CH2:2][N:3]([CH2:4][CH2:5][c:6]1[cH:7][cH:8][n:9][cH:10][cH:11]1)[C:15](=[O:16])[O:14][CH2:13][CH3:12]|EP1317432B1_0077
2.1.1|[C:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[O:9]=[C:10]1[NH:11][CH2:12][CH2:13][NH:14]1>[Na+].[O-]C(=O)O.ClC(Cl)Cl.C1CCOC1>[O:1]=[C:2]([c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1)[N:11]1[CH2:12][CH2:13][NH:14][C:10]1=[O:9]|US04012389A
1.7.17|[C&H3&D1:5]-[O&H1&+0&D1:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[CH3:1][OH:2].[CH3:3][CH:4]([CH3:5])[CH:6]1[O:7][CH2:8][CH2:9][N:10]1[CH2:11][CH:12]1[CH2:13][O:14]1>[Na+].C[O-]>[CH3:3][CH:4]([CH3:5])[CH:6]1[O:7][CH2:8][CH2:9][N:10]1[CH2:11][CH:12]([OH:14])[CH2:13][O:2][CH3:1]|EP3359541B1_0638
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][c:4]([n:5][nH:6]1)[CH3:7].[CH2:8]=[CH:9][C:10](=[O:11])Cl>CCN(CC)CC.c1ccccc1.c1cc[nH]n1>[CH2:8]=[CH:9][C:10](=[O:11])[n:6]1[n:5][c:4]([cH:3][c:2]1[CH3:1])[CH3:7]|US20200361939A1_1957
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[OH:9].Cl[c:10]1[n:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[nH:18]1>O.CC#N>[CH3:1][N:2]([c:10]1[n:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[nH:18]1)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[OH:9]|US20200362112A1_0197
1.6.4|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2](Cl)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15].[CH2:16]1[CH2:17][NH:18][CH2:19][CH2:20][NH:21]1>c1ccccc1>[CH3:1][CH:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15])[N:21]1[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1|US09694002B2_2095
3.10.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH:8][c:9]1[cH:10][s:11][cH:12][cH:13]1)[Cl:14].[CH3:15][CH2:16][O:17][C:18](=[O:19])[C:20](=[O:21])Cl>CCN(CC)CC.CCOC(C)=O.C1CCOC1.O>[CH3:15][CH2:16][O:17][C:18](=[O:19])[C:20](=[O:21])[c:10]1[s:11][cH:12][cH:13][c:9]1[NH:8][c:7]1[c:6]([cH:5][cH:4][cH:3][c:2]1[Cl:1])[Cl:14]|EP2513113B1_0409
2.1.1|[C:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[S:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[S:1]|[O-:1][N+:2](=[O:3])[C:4]([F:5])([CH2:6][NH:7][CH2:8][C:9]([F:10])([N+:11]([O-:12])=[O:13])[N+:14]([O-:15])=[O:16])[N+:17]([O-:18])=[O:19].[CH3:20][CH2:21][S:22][C:23](=[O:24])Cl>Cl[Ti](Cl)(Cl)Cl.ClC(Cl)Cl.CO.C>[CH3:20][CH2:21][S:22][C:23](=[O:24])[N:7]([CH2:8][C:9]([F:10])([N+:11]([O-:12])=[O:13])[N+:14]([O-:15])=[O:16])[CH2:6][C:4]([F:5])([N+:17]([O-:18])=[O:19])[N+:2]([O-:1])=[O:3]|US20200216439A1_2110
3.11.86|[C&H3&D1:6]-[C&H2&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.Cl[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>[Na+].CC([O-])=O.CC([O-])=O.CCOCC.CC(C)(C)[O-].C1CCOC1.[Pd+2]>[CH3:1][CH:2]([C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|EP1354887A1_0926
2.1.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][c:4]2[n:5]([c:6]([c:7]3[cH:8][n:9][c:10]4[nH:11][n:12][cH:13][c:14]4[c:15]3[n:16]2[n:17]1)=[O:18])-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[O:25]=[C:26](Cl)[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>c1ccncc1>[CH3:1][c:2]1[cH:3][c:4]2[n:5]([c:6]([c:7]3[cH:8][n:9][c:10]4[c:14]([cH:13][n:12][n:11]4[C:26](=[O:25])[c:27]4[cH:32][cH:31][cH:30][cH:29][cH:28]4)[c:15]3[n:16]2[n:17]1)=[O:18])-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|US20060183780A1_0157
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-Br.[C:3]-[N&H1&+0&D2:2]-[S:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[S:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][CH2:12][C:13](=[O:14])[O:15][CH3:16].[CH3:17][O:18][C:19](=[O:20])[c:21]1[cH:22][cH:23][c:24]([n:25][c:26]1[CH:27]([CH3:28])Br)[O:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>CN(C)C=O.O=C(O[K])O[K].I[Na]>[CH3:16][O:15][C:13](=[O:14])[CH2:12][N:11]([CH:27]([CH3:28])[c:26]1[n:25][c:24]([cH:23][cH:22][c:21]1[C:19](=[O:20])[O:18][CH3:17])[O:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)[S:8](=[O:9])(=[O:10])[c:5]1[cH:6][cH:7][c:2]([cH:3][cH:4]1)[CH3:1]|EP3275881A1_0104
1.2.16|[C:6]-[N&H2&+0&D1:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C:6]-[N&H1&+0&D2:5]-[C@&H1&+0&D3:3](-[C:4])-[C&H2&+0&D2:2]-[C:1]|[CH3:1][C@@:2]12[CH:3]=[CH:4][C:5]([N:6]1[C@H:7]([CH2:8][O:9]2)[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)=[O:16].[NH2:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>>[CH3:1][C@:2]12[O:9][CH2:8][C@@H:7]([N:6]1[C:5]([CH2:4][C@H:3]2[NH:17][CH2:18][c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1)=[O:16])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|EP0634412A1_0073
3.11.91|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[c:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C:4])(-[c:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6]Br.[CH3:7][O:8][c:9]1[cH:10][cH:11][c:12]2[CH2:13][CH2:14][C:15]([CH:16]([c:17]2[cH:18]1)[CH3:19])=[O:20]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:16]1([C:15]([CH2:14][CH2:13][c:12]2[cH:11][cH:10][c:9]([cH:18][c:17]21)[O:8][CH3:7])=[O:20])[CH3:19]|US20200031775A1_0582
1.6.4|[C&H3&D1:6]-[C&H1&+0&D3:5](-[O:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|Cl.[CH3:1][CH:2](Cl)[O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[O:10]=[c:11]1[n:12][cH:13][c:14]([cH:15][nH:16]1)[Cl:17]>ClCCl>[CH3:1][CH:2]([O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[n:16]1[cH:15][c:14]([cH:13][n:12][c:11]1=[O:10])[Cl:17]|EP1437352A1_0141
1.7.16|[C:6]-[O&H1&+0&D1:5].[S:4]-[N&H0&+0&D3:3]1-[C&H2&+0&D2:2]-[C:1]-1>>[C:6]-[O&H0&+0&D2:5]-[C&H2&+0&D2:2]-[C:1]-[N&H1&+0&D2:3]-[S:4]|[CH3:1][C:2]#[C:3][CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:12](=[O:13])(=[O:14])[N:15]1[CH2:16][CH:17]1[C:18](=[O:19])[O:20][CH3:21].[OH:22][CH2:23][CH2:24][Br:25]>CCOC(C)=O.CC[O+](CC)[B-](F)(F)F>[CH3:1][C:2]#[C:3][CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:12](=[O:13])(=[O:14])[NH:15][CH:17]([CH2:16][O:22][CH2:23][CH2:24][Br:25])[C:18](=[O:19])[O:20][CH3:21]|EP2663559B1_0140
2.3.9|[C:6]-[N&H1&+0&D2:5]-[c:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][c:2]1[cH:3][c:4]([n:5][c:6]([n:7]1)[NH:8][CH2:9][CH2:10][N:11]([CH:12]([CH3:13])[CH3:14])[CH:15]([CH3:16])[CH3:17])[CH3:18].[CH3:19][N:20]([CH3:21])[C:22](=[O:23])Cl>Cc1ccccc1.CCO.O[Na].[NaH]>[CH3:1][c:2]1[cH:3][c:4]([n:5][c:6]([n:7]1)[N:8]([CH2:9][CH2:10][N:11]([CH:12]([CH3:13])[CH3:14])[CH:15]([CH3:16])[CH3:17])[C:22](=[O:23])[N:20]([CH3:19])[CH3:21])[CH3:18]|EP1973889B1_0148
3.11.86|[C&H3&D1:6]-[C&H2&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)Br.[CH3:15][CH2:16][C:17](=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>CC(C)(C)P(C(C)(C)C)C(C)(C)C.CCCCCC.CCOC(C)=O.CC(C)(C)[O-].CC([O-])=O.CC([O-])=O.[Na+].[Pd+2]>[CH3:15][CH:16]([C:17](=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[c:12]1[cH:11][cH:10][c:9]([cH:14][cH:13]1)[C:2](=[O:1])[c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1|EP1354887A1_0914
3.10.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[Cl:9])[Cl:10].[O:11]=[C:12](Cl)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][Br:18]>O.Cl.ClCCl.Cl[Al](Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([c:8]1[Cl:9])[Cl:10])[C:12](=[O:11])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][Br:18]|EP0123543B1_0260
3.7.3|[C&H3&+0&D1:5]-[#12]-Cl.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][Mg]Cl.[O:2]=[C:3]([CH2:4][CH2:5][n:6]1[cH:7][cH:8][n:9][cH:10]1)[CH2:11][CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19]>[NH4+].[Cl-].C1CCOC1>[CH3:1][C:3]([OH:2])([CH2:11][CH2:12][c:13]1[cH:18][cH:17][c:16]([cH:15][cH:14]1)[Cl:19])[CH2:4][CH2:5][n:6]1[cH:10][n:9][cH:8][cH:7]1|EP3670506A1_0858
2.3.9|[N:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[N:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][S:4](=[O:5])(=[O:6])[c:7]1[n:8][cH:9][nH:10][n:11]1.[CH3:12][CH2:13][CH2:14][N:15]([CH2:16][CH2:17][CH3:18])[C:19](=[O:20])Cl>CCN(CC)CC.C1CCOC1>[CH3:12][CH2:13][CH2:14][N:15]([CH2:16][CH2:17][CH3:18])[C:19](=[O:20])[n:10]1[cH:9][n:8][c:7]([n:11]1)[S:4](=[O:5])(=[O:6])[CH2:3][CH2:2][CH3:1]|US20160083357A1_0336
2.1.1|[Cl&H0&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[c:1]>>[Cl&H0&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[Cl:8].[O:9]=[C:10]([Cl:11])Cl>Cc1ccccc1>[O:9]=[C:10]([Cl:11])[NH:1][c:2]1[cH:7][c:6]([cH:5][cH:4][cH:3]1)[Cl:8]|US20190315774A1_1286
3.10.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[Cl:9])[F:10].[cH:11]1[cH:12][cH:13][s:14][cH:15]1>c1ccccc1.Cl[Sn](Cl)(Cl)Cl.Cl>[O:1]=[C:2]([c:13]1[cH:12][cH:11][cH:15][s:14]1)[c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[Cl:9])[F:10]|US20170266173A1_0303
1.9.1|[C:6]-[C&H2&+0&D2:5]-Br.[O&H0&D1:4]=[P&H1&+0&D3:3](-[O:2])-[O:1]>>[C:6]-[C&H2&+0&D2:5]-[P&H0&+0&D4:3](=[O&H0&D1:4])(-[O:2])-[O:1]|[CH3:1][CH2:2][O:3][PH:4](=[O:5])[O:6][CH2:7][CH3:8].[O:9]=[C:10]([OH:11])[CH2:12]Br>[Na+].CCO.CC[O-]>[CH3:1][CH2:2][O:3][P:4](=[O:5])([CH2:12][C:10](=[O:9])[OH:11])[O:6][CH2:7][CH3:8]|EP0085488A2_0246
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-Br.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH:2](Br)[c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[F:9])[F:10])[F:11].[O:12]=[C:13]1[CH2:14][NH:15][c:16]2[n:17][cH:18][c:19]([cH:20][c:21]2[NH:22]1)[I:23]>>[CH3:1][CH:2]([c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[F:9])[F:10])[F:11])[N:22]1[C:13]([CH2:14][NH:15][c:16]2[n:17][cH:18][c:19]([cH:20][c:21]21)[I:23])=[O:12]|US09556169B2_0535
3.10.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][n:2]1[cH:3][cH:4][cH:5][c:6]1[CH2:7][C:8]#[N:9].[O:10]=[C:11](Cl)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>[Cl-].Cl.ClCCl>[CH3:1][n:2]1[c:6]([cH:5][cH:4][c:3]1[C:11](=[O:10])[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1)[CH2:7][C:8]#[N:9]|US20130245006A1_0319
3.5.3|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#30&+]>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[Br:1][c:2]1[cH:3][cH:4][n:5][c:6]([cH:7]1)Br.[CH2:8]1[CH2:9][CH:10]1[Zn+].[Br-]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCOC(C)=O.C1CCOC1.[O-]C(=O)O.[Na+]>[Br:1][c:2]1[cH:3][cH:4][n:5][c:6]([cH:7]1)[CH:10]1[CH2:8][CH2:9]1|EP2771327B1_0098
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH:3]([CH3:4])Br.[CH3:5][O:6][c:7]1[cH:8][n:9][nH:10][cH:11]1>O.CC(C)(C)[O-].C1CCOC1.[K+]>[CH3:5][O:6][c:7]1[cH:8][n:9][n:10]([cH:11]1)[CH:3]([CH3:4])[CH2:2][CH3:1]|US20200317637A1_0688
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][NH:2][CH2:3][CH2:4][OH:5].Cl[c:6]1[n:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[s:14]1>O>[CH3:1][N:2]([CH2:3][CH2:4][OH:5])[c:6]1[n:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[s:14]1|US20070123572A1_0157
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[o:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[o:1]|[CH3:1][NH:2][CH2:3][CH2:4][OH:5].Cl[c:6]1[n:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[o:14]1>O.C1CCOC1>[CH3:1][N:2]([CH2:3][CH2:4][OH:5])[c:6]1[n:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[o:14]1|US20020049240A1_0302
3.10.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2](Cl)[O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[OH:10][c:11]1[cH:12][cH:13][cH:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]12>O.Cc1ccccc1.Cl[Al](Cl)Cl>[O:1]=[C:2]([O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[c:12]1[cH:13][cH:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[c:11]1[OH:10]|US20200407344A1_0739
2.4.5|[C:6]-[N&H1&+0&D2:5]-[N:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[N:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[O:1]=[C:2]([OH:3])[CH:4]1[CH2:5][C:6](=[N:7][NH:8]1)[c:9]1[cH:10][cH:11][cH:12][s:13]1.[O:14]=[C:15](Cl)[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>O.CC(C)=O.O=C(O[K])O[K]>[O:14]=[C:15]([O:16][CH2:17][c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1)[N:8]1[N:7]=[C:6]([CH2:5][CH:4]1[C:2](=[O:1])[OH:3])[c:9]1[cH:10][cH:11][cH:12][s:13]1|US20200131192A1_0177
2.4.8|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O-c1:c:c:c:c:n:1>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[N:1]#[C:2][CH2:3][CH2:4][OH:5].[O:6]=[C:7]([O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][n:14]1)Oc1ccccn1>>[N:1]#[C:2][CH2:3][CH2:4][O:5][C:7](=[O:6])[O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][n:14]1|EP2909205B1_2390
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[n:8][c:9]1[nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3[n:17]1[c:18]2=[O:19].[CH3:20][CH2:21][C:22](=[O:23])Cl>>[CH3:20][CH2:21][C:22](=[O:23])[n:10]1[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[n:17]2[c:18]([c:5]3[cH:4][cH:3][c:2]([cH:7][c:6]3[n:8][c:9]12)[CH3:1])=[O:19]|US10844016B2_3622
3.10.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[o:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][o:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21.[O:18]=[C:19](Cl)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>COc1ccc(cc1)-c1oc2ccccc2c1C(=O)c1ccc(cc1)C.ClCCl.Cl[Sn](Cl)(Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[c:10]([o:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)[C:19](=[O:18])[c:20]1[cH:25][cH:24][cH:23][cH:22][cH:21]1|US09206151B2_0229
2.1.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=[O:9])Cl.[O:10]=[C:11]([O:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[CH:20]1[CH2:21][CH2:22][CH2:23][c:24]2[nH:25][c:26]3[cH:27][cH:28][cH:29][cH:30][c:31]3[c:32]21>O.CCOCC.CC(=O)O.CN(C)C=O.[NaH]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=[O:9])[n:25]1[c:26]2[cH:27][cH:28][cH:29][cH:30][c:31]2[c:32]2[c:24]1[CH2:23][CH2:22][CH2:21][CH:20]2[C:11](=[O:10])[O:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US20190276452A1_0839
1.7.9|[Cl&H0&D1:5]-[C&H0&+0&D3:4](=[S&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[Cl&H0&D1:5]-[C&H0&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])=[S&H0&D1:3]|[CH2:1]=[CH:2][CH2:3][O:4][c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[Cl:11])[OH:12].[S:13]=[C:14]([Cl:15])Cl>O.O[Na].ClC(Cl)Cl>[CH2:1]=[CH:2][CH2:3][O:4][c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[Cl:11])[O:12][C:14](=[S:13])[Cl:15]|US20160318875A1_0056
1.3.6|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[C:9](=[O:10])[OH:11])Br.[CH3:12][NH:13][CH2:14][C:15](=[O:16])[OH:17]>O.O.O.Cl.CC(C)O.O=C(O[K])O[K].[K].[Cu]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[C:9](=[O:10])[OH:11])[N:13]([CH3:12])[CH2:14][C:15](=[O:16])[OH:17]|EP3406252B1_0810
9.7.43|[N&H2&+0&D1:5]-[N&H2&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH2:1][NH2:2].[O:3]=[C:4](Cl)[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Br:11]>Nc1nc(c(nc1C=NNC(=O)c1ccc(cc1)Br)Cl)Cl>[NH2:1][NH:2][C:4](=[O:3])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Br:11]|US20180213779A1_0530
1.3.6|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([n:7]1)Br.[CH3:8][NH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][n:15]1>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.Cc1ccccc1.CC(C)(C)O[Na].[Fe+2]>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([n:7]1)[N:9]([CH3:8])[c:10]1[cH:11][cH:12][cH:13][cH:14][n:15]1|US20120004244A1_0217
2.6.1|[C:5]-[O&H1&+0&D1:4].[Cl&H0&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[Cl&H0&D1:3])=[O&H0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[CH2:9][OH:10])[O:11][CH3:12].[O:13]=[C:14]([Cl:15])Cl>c1ccccc1.O>[CH3:12][O:11][c:6]1[cH:5][cH:4][c:3]([cH:8][c:7]1[CH2:9][O:10][C:14](=[O:13])[Cl:15])[O:2][CH3:1]|EP3484878B1_1514
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-Br.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][O:3][CH2:4][C:5](=[O:6])[NH:7][c:8]1[c:9]([cH:10][cH:11][c:12]([c:13]1[CH3:14])[N+:15]([O-:16])=[O:17])[CH3:18].[CH3:19][O:20][C:21](=[O:22])[CH:23]([CH3:24])Br>O.C1CCOC1.[NaH]>[CH3:18][c:9]1[cH:10][cH:11][c:12]([c:13]([c:8]1[N:7]([C:5](=[O:6])[CH2:4][O:3][CH2:2][CH3:1])[CH:23]([CH3:24])[C:21](=[O:22])[O:20][CH3:19])[CH3:14])[N+:15]([O-:16])=[O:17]|US04410520A
3.10.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[Cl:9].[cH:10]1[cH:11][cH:12][c:13]2[CH2:14][c:15]3[cH:16][cH:17][cH:18][cH:19][c:20]3-[c:21]2[cH:22]1>S=C=S.Cl[Al](Cl)Cl>[O:1]=[C:2]([c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[Cl:9])[c:11]1[cH:10][cH:22][c:21]2[c:13]([cH:12]1)[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1-2|US06573293B2
1.3.6|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][NH:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][CH:8]([CH2:9][CH2:10]1)[NH:11][c:12]1[n:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]2[n:20]1[CH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28].Br[c:29]1[n:30][cH:31][cH:32][s:33]1>CC(=O)N(C)C.O=C(O[Na])O[Na].I[K]>[CH3:1][N:2]([CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][CH:8]([CH2:9][CH2:10]1)[NH:11][c:12]1[n:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]2[n:20]1[CH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28])[c:29]1[n:30][cH:31][cH:32][s:33]1|EP3736271A1_0222
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[S:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[S:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][CH3:12].Cl[c:13]1[cH:14][cH:15][c:16]([n:17][n:18]1)[Cl:19]>O.CN(C)C=O.[NaH]>[CH3:12][N:11]([c:13]1[cH:14][cH:15][c:16]([n:17][n:18]1)[Cl:19])[S:8](=[O:9])(=[O:10])[c:5]1[cH:6][cH:7][c:2]([cH:3][cH:4]1)[CH3:1]|US20110319379A1_0168
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Br.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][CH2:6][NH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22])[Cl:23].[O:24]=[C:25](Br)[CH2:26][Br:27]>O.O=C(O[K])O[K].ClC(Cl)Cl>[CH3:1][C:2](=[O:3])[O:4][CH2:5][CH2:6][N:7]([C:25](=[O:24])[CH2:26][Br:27])[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22])[Cl:23]|EP2897960B1_0303
2.3.9|[C:6]-[N&H1&+0&D2:5]-[C:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[O:1]=[C:2](Cl)[N:3]1[CH2:4][CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[CH2:12][O:13]1.[cH:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[N:20]1[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]1>ClCCl>[O:1]=[C:2]([N:3]1[CH2:4][CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[CH2:12][O:13]1)[N:23]1[CH2:24][CH2:25][N:20]([CH2:21][CH2:22]1)[c:17]1[cH:18][cH:19][cH:14][cH:15][cH:16]1|US10450301B2_0454
2.4.5|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][S:2](=[O:3])(=[O:4])[NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[C:12]([OH:13])([C:14]([F:15])([F:16])[F:17])[C:18]([F:19])([F:20])[F:21].[CH3:22][CH2:23][O:24][C:25](=[O:26])Cl>[O-]C([O-])=O.CC#N.[K+].[K+]>[CH3:22][CH2:23][O:24][C:25](=[O:26])[N:5]([c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[C:12]([OH:13])([C:14]([F:15])([F:16])[F:17])[C:18]([F:19])([F:20])[F:21])[S:2]([CH3:1])(=[O:3])=[O:4]|US20030017948A1_0145
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[O:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([cH:10][c:11]1[NH:12][CH3:13])Cl.[CH3:14][NH:15][O:16][CH3:17]>C1COCCO1.[O-]C([O-])=O.[Na+].[Na+]>[CH3:17][O:16][N:15]([CH3:14])[c:9]1[cH:10][c:11]([c:6]([cH:7][n:8]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1])[NH:12][CH3:13]|EP2909192B1_0563
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH:8][CH2:9][CH:10]1[O:11][CH2:12][CH2:13][O:14]1)[CH3:15].[O:16]=[C:17](Cl)[CH2:18][Cl:19]>C1COCCO1.CCOCC.O=C(O)O[Na].O>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[N:8]([CH2:9][CH:10]1[O:11][CH2:12][CH2:13][O:14]1)[C:17](=[O:16])[CH2:18][Cl:19])[CH3:15]|US10870706B2_0352
1.6.4|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2](Cl)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[F:9].[cH:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][CH:21]([CH2:22][CH2:23]1)[NH:24][c:25]1[n:26][c:27]2[cH:28][cH:29][cH:30][cH:31][c:32]2[nH:33]1>O.CC(=O)CC(C)C.O=C(O[Na])O[Na].I[K]>[CH3:1][CH:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[F:9])[n:33]1[c:25]([n:26][c:27]2[cH:28][cH:29][cH:30][cH:31][c:32]21)[NH:24][CH:21]1[CH2:22][CH2:23][N:18]([CH2:19][CH2:20]1)[CH2:17][CH2:16][c:13]1[cH:14][cH:15][cH:10][cH:11][cH:12]1|US10301315B2_0834
9.7.262|[C&H0&-&D1:5]#[N&H0&D1:4].[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H0&+0&D2:5](#[N&H0&D1:4])-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[C-:1]#[N:2].[CH3:3][C@@H:4]1[CH:5]=[CH:6][CH2:7][CH2:8][C@H:9]1[CH:10]=[O:11].[K+]>O.CCO.O=S(O)O[Na]>[CH3:3][C@@H:4]1[CH:5]=[CH:6][CH2:7][CH2:8][C@H:9]1[CH:10]([OH:11])[C:1]#[N:2]|US20190330146A1_0678
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][n:2]1[c:3]([n:4][cH:5][c:6]1-[c:7]1[n:8][n:9][c:10]2[cH:11][cH:12][c:13]([n:14][n:15]12)Cl)[N+:16]([O-:17])=[O:18].[CH3:19][N:20]([CH3:21])[CH2:22][CH2:23][NH:24][CH3:25]>CN(C)C=O>[CH3:25][N:24]([CH2:23][CH2:22][N:20]([CH3:19])[CH3:21])[c:13]1[cH:12][cH:11][c:10]2[n:9][n:8][c:7]([n:15]2[n:14]1)-[c:6]1[cH:5][n:4][c:3]([n:2]1[CH3:1])[N+:16]([O-:17])=[O:18]|EP1787991B2_0244
2.4.10|[C:5]-[O&H1&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-c1:c:c:c:c:c:1>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[NH:9][C:10](=[O:11])Oc1ccccc1)-[c:12]1[cH:13][n:14]([c:15]2[n:16][cH:17][n:18][c:19]([c:20]12)[NH2:21])[CH:22]1[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1.[CH3:28][c:29]1[cH:30][c:31]([n:32][o:33]1)[CH2:34][OH:35]>c1ccncc1>[CH3:28][c:29]1[cH:30][c:31]([n:32][o:33]1)[CH2:34][O:35][C:10](=[O:11])[NH:9][c:8]1[cH:7][cH:6][c:5]([cH:4][c:3]1[O:2][CH3:1])-[c:12]1[cH:13][n:14]([c:15]2[n:16][cH:17][n:18][c:19]([c:20]12)[NH2:21])[CH:22]1[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1|US20200397760A1_1366
1.6.4|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[o:6][c:7]([c:8]3[CH2:9][NH:10][CH2:11][CH2:12][c:13]3[c:14]2[cH:15][c:16]1[O:17][CH3:18])=[O:19].[CH3:20][CH:21](Cl)[CH2:22][N:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[o:6][c:7]([c:8]3[CH2:9][N:10]([CH2:11][CH2:12][c:13]3[c:14]2[cH:15][c:16]1[O:17][CH3:18])[CH:21]([CH3:20])[CH2:22][N:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1)=[O:19]|US20200199073A1_0911
3.10.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][c:8]2[n:9][cH:10][cH:11][n:12]2-[c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]21.[CH3:19][CH2:20][O:21][C:22](=[O:23])Cl>CN(C)C=O>[CH3:19][CH2:20][O:21][C:22](=[O:23])[c:10]1[cH:11][n:12]2[c:8]([CH2:7][N:6]([c:18]3[cH:17][cH:16][cH:15][cH:14][c:13]3-2)[C:4](=[O:5])[O:3][CH2:2][CH3:1])[n:9]1|US20150218173A1_0837
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][NH:2][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7]1.[N:8]#[C:9][c:10]1[cH:11][c:12]([c:13]2[n:14][c:15]([nH:16][c:17]2[c:18]1Cl)[C:19]([F:20])([F:21])[F:22])[N+:23]([O-:24])=[O:25]>>[CH3:1][N:2]([c:18]1[c:10]([cH:11][c:12]([c:13]2[n:14][c:15]([nH:16][c:17]21)[C:19]([F:20])([F:21])[F:22])[N+:23]([O-:24])=[O:25])[C:9]#[N:8])[CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7]1|EP3397616B1_0245
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[N:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[N:1]|[CH3:1][C:2](=[O:3])[S:4][CH2:5][CH2:6][C:7](=[O:8])Cl.[O:9]=[C:10]([OH:11])[CH:12]1[CH2:13][C:14](=[N:15][NH:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O.CCOC(C)=O.O=C(O[Na])O[Na]>[CH3:1][C:2](=[O:3])[S:4][CH2:5][CH2:6][C:7](=[O:8])[N:16]1[N:15]=[C:14]([CH2:13][CH:12]1[C:10](=[O:9])[OH:11])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US06235787B1
4.1.42|[C:6]-[C&H0&+0&D2:5]#[C&H0&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H1&+0&D2:1]:[c:2]:[c:3]:[c&H1&+0&D2:4]:1|[CH3:1][S:2][c:3]1[cH:4][n:5][c:6]([c:7]([n:8]1)[C:9]#[C:10][CH2:11][OH:12])[NH2:13]>O.CN(C)C=O.I[Cu]>[CH3:1][S:2][c:3]1[cH:4][n:5][c:6]2[nH:13][c:10]([cH:9][c:7]2[n:8]1)[CH2:11][OH:12]|EP2968282B1_0114
2.4.5|[C:6]-[N&H1&+0&D2:5]-[O:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[O:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][O:2][C:3](=[O:4])Cl.[CH3:5][CH:6]([CH3:7])[N:8]([CH3:9])[C:10](=[O:11])[NH:12][O:13][c:14]1[cH:15][c:16]([cH:17][c:18]([cH:19]1)[Cl:20])[Cl:21]>O.c1ccncc1.C1CCOC1>[CH3:5][CH:6]([CH3:7])[N:8]([CH3:9])[C:10](=[O:11])[N:12]([O:13][c:14]1[cH:15][c:16]([cH:17][c:18]([cH:19]1)[Cl:20])[Cl:21])[C:3](=[O:4])[O:2][CH3:1]|EP1546150B1_0429
3.11.93|[C:6]-[C&H2&+0&D2:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][s:9][cH:10]1.[CH3:11][O:12][C:13](=[O:14])Cl>CC(C)NC(C)C.C1CCOC1.ClCCl>[CH3:11][O:12][C:13](=[O:14])[CH:5]([C:3](=[O:4])[O:2][CH3:1])[c:6]1[cH:7][cH:8][s:9][cH:10]1|US20200392138A1_0340
3.11.93|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][CH:3]([O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11])[C:12](=[O:13])Cl.[O:14]=[C:15]1[CH2:16][C:17]([c:18]2[cH:19][cH:20][cH:21][cH:22][c:23]12)=[O:24]>Cl.ClC(Cl)Cl.c1ccncc1.C1CCNCC1>[CH3:1][CH2:2][CH:3]([O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11])[C:12](=[O:13])[CH:16]1[C:15]([c:23]2[cH:22][cH:21][cH:20][cH:19][c:18]2[C:17]1=[O:24])=[O:14]|US20180148453A1_0262
3.10.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])Cl.[C:6](#[C:7][c:8]1[cH:9][n:10][c:11]([s:12]1)-[c:13]1[cH:14][cH:15][cH:16][s:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>[NH4+].[Cl-].CCCCCC.CCCC[Li].C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:16]1[cH:15][cH:14][c:13]([s:17]1)-[c:11]1[n:10][cH:9][c:8]([s:12]1)[C:7]#[C:6][c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1|US20030078276A1_0101
2.4.5|[N&H2&+0&D1:5]-[O&H1&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[N&H1&+0&D2:5](-[O&H1&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|Cl.[NH2:1][OH:2].[O:3]=[C:4](Cl)[O:5][CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1>>[O:3]=[C:4]([NH:1][OH:2])[O:5][CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1|US20130274479A1_0324
2.4.5|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[S:3]-[N&H1&+0&D2:2]-[n:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[N&H0&+0&D3:2](-[S:3])-[n:1]|[CH3:1][S:2](=[O:3])(=[O:4])[NH:5][n:6]1[c:7]([nH:8][c:9]2[cH:10][c:11]([c:12]([cH:13][c:14]2[c:15]1=[O:16])-[c:17]1[cH:18][cH:19][n:20][n:21]1[CH3:22])[C:23]([F:24])([F:25])[F:26])=[O:27].[CH3:28][O:29][C:30](=[O:31])Cl>>[CH3:22][n:21]1[n:20][cH:19][cH:18][c:17]1-[c:12]1[cH:13][c:14]2[c:9]([cH:10][c:11]1[C:23]([F:24])([F:25])[F:26])[nH:8][c:7]([n:6]([c:15]2=[O:16])[N:5]([C:30](=[O:31])[O:29][CH3:28])[S:2]([CH3:1])(=[O:3])=[O:4])=[O:27]|US20130053381A1_0681
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[S:3]-[N&H1&+0&D2:2]-[n:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[S:3])-[n:1]|[CH3:1][S:2](=[O:3])(=[O:4])[NH:5][n:6]1[c:7]([nH:8][c:9]2[cH:10][c:11]([c:12]([cH:13][c:14]2[c:15]1=[O:16])-[c:17]1[cH:18][cH:19][n:20][n:21]1[CH3:22])[C:23]([F:24])([F:25])[F:26])=[O:27].[CH3:28][CH2:29][CH2:30][CH2:31][C:32](=[O:33])Cl>c1ccncc1>[CH3:22][n:21]1[n:20][cH:19][cH:18][c:17]1-[c:12]1[cH:13][c:14]2[c:9]([cH:10][c:11]1[C:23]([F:24])([F:25])[F:26])[nH:8][c:7]([n:6]([c:15]2=[O:16])[N:5]([C:32](=[O:33])[CH2:31][CH2:30][CH2:29][CH3:28])[S:2]([CH3:1])(=[O:3])=[O:4])=[O:27]|US20130053381A1_0701
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[O:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[O:1]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][C:6](=[O:7])Cl.[CH3:8][CH:9]([CH3:10])[NH:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH3:17]>CC#N.O=C(O[K])O[K]>[CH3:17][CH2:16][O:15][CH2:14][CH2:13][O:12][N:11]([C:6](=[O:7])[CH2:5][O:4][C:2]([CH3:1])=[O:3])[CH:9]([CH3:8])[CH3:10]|US20180273494A1_0669
2.1.1|[C:6]-[N&H1&+0&D2:5]-[N:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[N:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2]1[CH2:3][NH:4][N:5]([C:6]([NH:7]1)=[O:8])[CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16].[O:17]=[C:18](Cl)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25]>c1ccccc1>[O:1]=[C:2]1[CH2:3][N:4]([N:5]([C:6]([NH:7]1)=[O:8])[CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16])[C:18](=[O:17])[c:19]1[cH:24][cH:23][c:22]([cH:21][cH:20]1)[Cl:25]|US20200270225A1_0728
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[n:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])Cl.[CH3:9][O:10][C:11](=[O:12])[c:13]1[c:14]([c:15]([c:16]([n:17]1[NH:18][CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[Cl:26])[Cl:27])[Cl:28]>C1COCCO1>[CH3:9][O:10][C:11](=[O:12])[c:13]1[c:14]([c:15]([c:16]([n:17]1[N:18]([CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[C:7](=[O:8])[CH2:6][C:4](=[O:5])[O:3][CH2:2][CH3:1])[Cl:26])[Cl:27])[Cl:28]|US08217043B2_0507
2.1.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[O:1]=[C:2]1[NH:3][c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[NH:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]12.[O:17]=[C:18](Cl)[c:19]1[cH:20][cH:21][n:22][cH:23][cH:24]1.Cl>c1ccncc1.C1COCCO1>[O:1]=[C:2]1[NH:3][c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[N:10]([c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]12)[C:18](=[O:17])[c:19]1[cH:24][cH:23][n:22][cH:21][cH:20]1|US20140057953A1_0256
3.11.91|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[C:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH:7]([C:8]([c:9]2[c:10]([c:11]1[Cl:12])[Cl:13])=[O:14])[CH3:15].Br[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>CC(C)(C)O[K].c1ccccc1.CC(C)(C)O.O>[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][C:7]([C:8]([c:9]2[c:10]([c:11]1[Cl:12])[Cl:13])=[O:14])([CH3:15])[CH2:16][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|EP3191449B1_0266
3.7.2|[C&H3&+0&D1:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][CH:2]([CH3:3])[N:4]1[CH2:5][CH:6]([O:7][CH2:8][C:9]1=[O:10])[CH2:11][O:12][c:13]1[cH:14][cH:15][c:16]2[C:17]([CH2:18][CH2:19][c:20]2[cH:21]1)=[O:22].[CH3:23][Mg]Br>O.CCOC(C)=O.C1CCOC1>[CH3:1][CH:2]([CH3:3])[N:4]1[CH2:5][CH:6]([O:7][CH2:8][C:9]1=[O:10])[CH2:11][O:12][c:13]1[cH:14][cH:15][c:16]2[c:20]([cH:21]1)[CH2:19][CH2:18][C:17]2([CH3:23])[OH:22]|US08309730B2_0499
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH2:1]=[CH:2][CH2:3][NH:4][CH2:5][CH:6]=[CH2:7].[O:8]=[C:9](Br)[CH2:10][Br:11]>CC(C)=O.O=C=O.ClCCl>[CH2:1]=[CH:2][CH2:3][N:4]([CH2:5][CH:6]=[CH2:7])[C:9](=[O:8])[CH2:10][Br:11]|EP3489220A1_0143
3.10.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[o:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[o:1]|[O:1]=[C:2](Cl)[CH:3]1[CH2:4][CH2:5]1.[Cl:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][cH:16][o:17]1>O.O.Cl.S=C=S.Cl[Al](Cl)Cl>[O:1]=[C:2]([c:16]1[cH:15][cH:14][c:13]([o:17]1)-[c:10]1[cH:11][cH:12][c:7]([cH:8][cH:9]1)[Cl:6])[CH:3]1[CH2:4][CH2:5]1|US08436043B2_2558
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[S:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[S:1]|[O:1]=[S:2](=[O:3])([NH:4][CH2:5][CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH2:13][CH2:14][OH:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22].[CH3:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30](=[O:31])Cl>CCN(CC)CC.ClCCl.O.Cl>[CH3:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30](=[O:31])[N:4]([CH2:5][CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH2:13][CH2:14][OH:15])[S:2](=[O:1])(=[O:3])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22]|US20200331968A1_0830
3.10.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[C:2](Cl)[CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1.[cH:9]1[cH:10][cH:11][nH:12][cH:13]1>[NH4+].O.[Cl-].CCOCC.CI.[Mg]>[O:1]=[C:2]([c:11]1[cH:10][cH:9][cH:13][nH:12]1)[CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1|US04386092A
3.11.93|[C:6]-[C&H2&+0&D2:5]-[c:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:6]-[C&H1&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[O:1]=[C:2]([CH2:3][c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[Cl:10])[Cl:11])[NH:12][c:13]1[n:14][cH:15][cH:16][s:17]1.[O:18]=[C:19](Cl)[CH:20]1[CH2:21][CH2:22][CH2:23][CH2:24]1>C[Si](C)(C)[N-][Si](C)(C)C.C1CCOC1.[Li+]>[O:18]=[C:19]([CH:3]([C:2](=[O:1])[NH:12][c:13]1[n:14][cH:15][cH:16][s:17]1)[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[Cl:10])[Cl:11])[CH:20]1[CH2:21][CH2:22][CH2:23][CH2:24]1|US20160257676A1_0259
3.11.91|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[S:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C:4])(-[S:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH3:6])[S:7](=[O:8])(=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[Br:16][CH2:17][CH2:18][CH2:19]Br>C[Si](C)(C)[N-][Si](C)(C)C.C1CCOC1.[Li+]>[CH3:1][O:2][C:3](=[O:4])[C:5]([CH3:6])([CH2:19][CH2:18][CH2:17][Br:16])[S:7](=[O:8])(=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|EP3468957B1_0120
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH:2](Br)[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[NH2:9][c:10]1[n:11][cH:12][nH:13][n:14]1>>[CH3:1][CH:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[n:13]1[cH:12][n:11][c:10]([n:14]1)[NH2:9]|US20200277296A1_0778
1.3.6|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[NH:14][CH3:15].[O:16]=[CH:17][c:18]1[cH:19][cH:20][cH:21][n:22][c:23]1Br>CC(C)N(CC)C(C)C>[CH3:15][N:14]([c:23]1[n:22][cH:21][cH:20][cH:19][c:18]1[CH:17]=[O:16])[CH:11]1[CH2:10][CH2:9][N:8]([CH2:13][CH2:12]1)[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20080269249A2_0134
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[N:4].[N:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[N:4])-[C&H0&+0&D3:2](=[N:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[OH:9])/[CH:10]=[N:11]/[NH:12][CH3:13].[O:14]=[S:15]1([N:16]=[C:17]([c:18]2[cH:19][cH:20][cH:21][cH:22][c:23]21)Cl)=[O:24]>C1CCOC1>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[OH:9])/[CH:10]=[N:11]/[N:12]([CH3:13])[C:17]1=[N:16][S:15]([c:23]2[cH:22][cH:21][cH:20][cH:19][c:18]12)(=[O:14])=[O:24]|US20200115353A1_0446
3.10.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Br.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([Br:4])[C:5](=[O:6])Br.[F:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>S=C=S.Cl[Al](Cl)Cl>[CH3:1][C:2]([CH3:3])([Br:4])[C:5](=[O:6])[c:11]1[cH:12][cH:13][c:8]([cH:9][cH:10]1)[F:7]|EP3305781A1_0829
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][CH2:5][CH2:6][CH:7]([CH3:8])[CH2:9][CH2:10][CH2:11][CH:12]([CH3:13])Br.[cH:14]1[cH:15][nH:16][cH:17][n:18]1>C1CCOC1>[CH3:1][CH:2]([CH3:3])[CH2:4][CH2:5][CH2:6][CH:7]([CH3:8])[CH2:9][CH2:10][CH2:11][CH:12]([CH3:13])[n:16]1[cH:15][cH:14][n:18][cH:17]1|EP2308872A1_0308
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][CH:2]([CH3:3])[N:4]1[C:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[NH:12][S:13]1(=[O:14])=[O:15])=[O:16].[O:17]=[C:18](Cl)[CH2:19][Cl:20]>CC#N.CC(C)(C)[O-].[K+]>[CH3:1][CH:2]([CH3:3])[N:4]1[C:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[N:12]([S:13]1(=[O:14])=[O:15])[C:18](=[O:17])[CH2:19][Cl:20])=[O:16]|US10556884B2_0434
3.11.83|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[C:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C:4])(-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[C:8](=[O:9])[O:10][CH2:11][CH3:12].Br[CH2:13][CH2:14][CH2:15][CH2:16][O:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>Cc1ccccc1.CN(C)C=O.[H][H].[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH2:13][CH2:14][CH2:15][CH2:16][O:17][c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1)[C:8](=[O:9])[O:10][CH2:11][CH3:12]|US10611781B2_0411
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[cH:13]1)[CH:14]([CH3:15])Br.[cH:16]1[cH:17][nH:18][cH:19][n:20]1>[Na+].CN(C)C=O.I[K].c1c[n-]cn1.[NaH]>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[cH:13]1)[CH:14]([CH3:15])[n:18]1[cH:19][n:20][cH:16][cH:17]1|US20180258044A1_0906
2.1.1|[C:6]-[N&H1&+0&D2:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][CH:2]([CH3:3])[NH:4][c:5]1[n:6][n:7][c:8]([s:9]1)[CH3:10].[O:11]=[C:12](Cl)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>c1ccncc1>[CH3:10][c:8]1[n:7][n:6][c:5]([s:9]1)[N:4]([C:12](=[O:11])[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)[CH:2]([CH3:1])[CH3:3]|US06608084B1
1.6.4|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH:2](Cl)[c:3]1[cH:4][cH:5][c:6]2-[c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[CH2:13][c:14]2[cH:15]1.[cH:16]1[n:17][cH:18][nH:19][n:20]1>O>[CH3:1][CH:2]([c:3]1[cH:4][cH:5][c:6]2-[c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[CH2:13][c:14]2[cH:15]1)[n:19]1[cH:18][n:17][cH:16][n:20]1|US08685959B2_0194
1.3.7|[C:6]-[N&H1&+0&D2:5]-[N&H2&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][NH:2][CH2:3][CH2:4][OH:5].Cl[c:6]1[cH:7][cH:8][c:9]([n:10][n:11]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18]>CCCCO>[NH2:1][N:2]([CH2:3][CH2:4][OH:5])[c:6]1[cH:7][cH:8][c:9]([n:10][n:11]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18]|US20200199129A1_0375
3.11.84|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-Br.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]([CH3:8])=[O:9].[CH3:10][C:11](=[O:12])[CH:13]([CH3:14])Br>[Na+].CC[O-].CCO.[Na]>[CH3:10][C:11](=[O:12])[CH:13]([CH3:14])[CH:6]([C:7]([CH3:8])=[O:9])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US10377697B2_0414
2.4.5|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])Cl.[N:6]#[C:7][c:8]1[nH:9][c:10]([n:11][c:12]1[C:13]#[N:14])[NH2:15]>CC(C)=O.O=C(O[K])O[K]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[n:9]1[c:10]([n:11][c:12]([c:8]1[C:7]#[N:6])[C:13]#[N:14])[NH2:15]|US10526294B2_0818
2.4.8|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O-c1:c:c:c:c:c:1>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][C:2](=[O:3])[OH:4].[O:5]=[C:6]([O:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)Oc1ccccc1>>[CH3:1][C:2](=[O:3])[O:4][C:6](=[O:5])[O:7][c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1|EP3735990A1_0216
3.7.3|[C&H3&+0&D1:5]-[#12]-Cl.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[O:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[O:1]|[CH2:1]=[C:2]([CH3:3])[C:4](=[O:5])[O:6][CH:7]1[CH:8]2[CH2:9][CH:10]3[CH:11]1[O:12][C:13]([CH:14]3[CH2:15]2)=[O:16].[CH3:17][Mg]Cl>>[CH2:1]=[C:2]([CH3:3])[C:4](=[O:5])[O:6][CH:7]1[CH:8]2[CH2:9][CH:10]3[CH:11]1[O:12][C:13]([CH:14]3[CH2:15]2)([CH3:17])[OH:16]|
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][NH:3][CH2:4][CH3:5].[CH3:6][CH:7](Br)[c:8]1[n:9][n:10][c:11]2[CH2:12][N:13]=[C:14]([c:15]3[c:16]([c:17]([cH:18][cH:19][c:20]3-[n:21]21)[C:22]#[N:23])[C:24]#[N:25])[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[Br:32]>I[Na]>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH:7]([CH3:6])[c:8]1[n:9][n:10][c:11]2[CH2:12][N:13]=[C:14]([c:15]3[c:16]([c:17]([cH:18][cH:19][c:20]3-[n:21]21)[C:22]#[N:23])[C:24]#[N:25])[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[Br:32]|US08362241B2_1504
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[O:1]=[C:2](Cl)[CH2:3][Cl:4].[O:5]=[C:6]1[NH:7][c:8]2[cH:9][c:10]([c:11]([cH:12][c:13]2[NH:14][c:15]2[n:16][cH:17][cH:18][cH:19][c:20]12)[Br:21])[Br:22]>O.CCN(CC)CC>[O:5]=[C:6]1[NH:7][c:8]2[cH:9][c:10]([c:11]([cH:12][c:13]2[N:14]([c:15]2[n:16][cH:17][cH:18][cH:19][c:20]12)[C:2](=[O:1])[CH2:3][Cl:4])[Br:21])[Br:22]|EP3527642A1_0141
2.1.10|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O-C.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][NH:3][CH2:4][CH3:5].[CH3:6][C:7]([CH3:8])=[CH:9][CH2:10][CH2:11][C:12]([CH3:13])=[CH:14][CH2:15][CH2:16][C:17](=[O:18])[CH2:19][C:20](=[O:21])OC>>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[C:20](=[O:21])[CH2:19][C:17](=[O:18])[CH2:16][CH2:15][CH:14]=[C:12]([CH3:13])[CH2:11][CH2:10][CH:9]=[C:7]([CH3:6])[CH3:8]|US04987132A
3.11.46|[C:6]=[C&H1&+0&D2:5]-[C:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:6]=[C&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][c:2]1[cH:3][n:4][c:5]([c:6]([cH:7]1)[CH:8]=[O:9])[Cl:10].[O:11]=[C:12]1[CH:13]=[CH:14][CH2:15][CH2:16]1>O.CO.c1c[nH]cn1>[CH3:1][c:2]1[cH:3][n:4][c:5]([c:6]([cH:7]1)[CH:8]([OH:9])[C:13]1=[CH:14][CH2:15][CH2:16][C:12]1=[O:11])[Cl:10]|US07666883B2_0099
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[c:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH2:1]=[CH:2][c:3]1[cH:4][n:5][c:6]([c:7]2[c:8]1[c:9]([cH:10][cH:11][cH:12]2)[NH:13][C@@H:14]1[CH2:15][CH2:16][C@H:17]([CH2:18][CH2:19]1)[N:20]([CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[Cl:35]>C=Cc1cncc2c1c(ccc2)NC1CCC(CC1)N(Cc1ccccc1)C(=O)OC(C)(C)C>[CH3:32][C:31]([CH3:33])([CH3:34])[O:30][C:28](=[O:29])[N:20]([CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[C@@H:17]1[CH2:16][CH2:15][C@H:14]([CH2:19][CH2:18]1)[N:13]1[CH2:1][CH2:2][c:3]2[cH:4][n:5][c:6]([c:7]3[c:8]2[c:9]1[cH:10][cH:11][cH:12]3)[Cl:35]|US20040157866A1_0738
4.2.36|[C:5]-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[c:2].[O&H0&+0&D2:1](-[#11])-Cl>>[C:5]-[C&H1&+0&D3:4]1-[C&H1&+0&D3:3](-[c:2])-[O&H0&+0&D2:1]-1|[Br:1][c:2]1[cH:3][cH:4][c:5]2[CH:6]=[CH:7][CH2:8][c:9]2[cH:10]1.Cl[O:11][Na]>CC(C)(C)c1cc(c(c(c1)C(C)(C)C)[O-])C=N[C@H]1CCCC[C@@H]1N=Cc1cc(cc(c1[O-])C(C)(C)C)C(C)(C)C.[O-][n+]1ccc(cc1)CCCc1ccccc1.ClCCl.O.O.[Na+].[Cl-].[Cl-].[Mn+3]>[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[CH2:8][CH:7]1[O:11][CH:6]21|US09034897B2_0166
1.2.17|[C&H1&+0&D1:6]#[C&H0&+0&D2:5]-[C:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H1&+0&D2:6](=[C&H1&+0&D2:5]-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH:1]#[C:2][C:3](=[O:4])[O:5][CH2:6][CH3:7].[CH2:8]1[CH2:9][CH2:10][NH:11][CH2:12]1>c1ccccc1>[CH3:7][CH2:6][O:5][C:3](=[O:4])[CH:2]=[CH:1][N:11]1[CH2:10][CH2:9][CH2:8][CH2:12]1|US20200123166A1_0425
3.5.3|[c:6]:[c&H0&+0&D3:5](:[n:4])-Br.[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#30]-Br>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[O:1]=[C:2]([NH:3][c:4]1[n:5][c:6]2[cH:7][cH:8][c:9]([cH:10][n:11]2[c:12]1Br)[F:13])[C:14]([F:15])([F:16])[F:17].Br[Zn][CH:18]1[CH2:19][CH2:20]1>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.C1CCOC1.Cl[Pd]Cl.[Fe+2]>[O:1]=[C:2]([NH:3][c:4]1[n:5][c:6]2[cH:7][cH:8][c:9]([cH:10][n:11]2[c:12]1[CH:18]1[CH2:19][CH2:20]1)[F:13])[C:14]([F:15])([F:16])[F:17]|US10647661B2_2213
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[C:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[C:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH2:1]=[CH:2][C:3]#[N:4].[O:5]=[c:6]1[nH:7][n:8][c:9]2[cH:10][cH:11][c:12]([n:13][n:14]21)[Cl:15]>O.CN(C)C=O.CC(C)(C)[O-].[K+]>[N:4]#[C:3][CH2:2][CH2:1][n:7]1[n:8][c:9]2[cH:10][cH:11][c:12]([n:13][n:14]2[c:6]1=[O:5])[Cl:15]|US20150266857A1_0571
2.6.2|[C&H3&D1:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][OH:2].[O-][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][n:10]1>O=[Mo](=O)(=O)(=O)=O>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][n:10]1|US20140057895A1_0567
1.2.17|[C&H1&+0&D1:6]#[C&H0&+0&D2:5]-[C:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H1&+0&D2:6](=[C&H1&+0&D2:5]-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH:1]#[C:2][CH:3]=[O:4].[CH3:5][CH:6]([CH3:7])[c:8]1[n:9][c:10]([c:11]([nH:12]1)-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[F:19])-[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[F:26]>C1CCOC1>[CH3:5][CH:6]([CH3:7])[c:8]1[n:9][c:10]([c:11]([n:12]1[CH:1]=[CH:2][CH:3]=[O:4])-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[F:19])-[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[F:26]|US20090227602A1_2001
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[O:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&+0&D1:6]-[C&H1&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH2:1]=[CH:2][O:3][CH2:4][CH3:5].[O:6]=[CH:7][c:8]1[c:9]([n:10][nH:11][c:12]1[Br:13])[Br:14]>Cl.Cc1ccccc1>[CH3:5][CH2:4][O:3][CH:2]([CH3:1])[n:11]1[n:10][c:9]([c:8]([c:12]1[Br:13])[CH:7]=[O:6])[Br:14]|US20110230476A1_1129
4.1.5|[C:6]-[N&H1&+0&D2:5]-[C&H1&+0&D2:4]=O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:6]-[N&H0&+0&D2:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[c:1]|O=[CH:1][NH:2][CH2:3][CH:4]1[CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[CH2:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]21>c1ccccc1.O=P(O)(O)O.ClC(Cl)Cl.O[Na].O.O.O>[CH:1]1=[N:2][CH2:3][CH:4]2[CH2:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[CH2:12][c:13]3[cH:14][cH:15][cH:16][c:17]1[c:18]32|US20200113879A1_1105
2.5.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[N&H1&D1:3]=[C&H0&+0&D3:2](-[N:1])-S-C>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[N&H1&D1:3])-[N:1]|I.CS[C:1](=[NH:2])[NH:3][CH:4]([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[CH2:17]1[CH2:18][NH:19][CH2:20][CH2:21][O:22]1>CC(C)(C)O.O[Na].ClO[Na]>[NH:2]=[C:1]([NH:3][CH:4]([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[N:19]1[CH2:20][CH2:21][O:22][CH2:17][CH2:18]1|US09227971B2_1931
2.1.2|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&-].[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[Na+].Cl.[CH3:1][C:2]([O-])=[O:3].[NH2:4][CH:5]1[CH2:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[CH:13]([CH2:14]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O.CC(=O)OC(C)=O.CC(=O)OCC>[CH3:1][C:2](=[O:3])[NH:4][CH:5]1[CH2:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[CH:13]([CH2:14]1)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20140336380A1_0058
3.9.24|[c:6]:[c&H0&+0&D3:5](:[c:4])-Br.[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#12]-Br>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[Cl:9])Br.Br[Mg][CH:10]1[CH2:11][CH2:12]1>c1ccc(cc1)P(CCCP(c1ccccc1)c1ccccc1)c1ccccc1.C1CCOC1.Cl[Ni]Cl>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[Cl:9])[CH:10]1[CH2:11][CH2:12]1|US10590078B2_0438
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[P:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[P:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][CH2:10][CH2:11][N:12]([CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20][NH:21][c:22]1[n:23][c:24]([cH:25][c:26]([n:27]1)[N:28]1[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]1)[NH2:34])[C:35](=[O:36])[O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[CH:42]1[CH2:43][CH2:44][CH2:45][CH2:46][CH2:47]1.[CH2:48]=[CH:49][P:50](=[O:51])([O:52][CH2:53][CH3:54])[O:55][CH2:56][CH3:57]>>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][CH2:10][CH2:11][N:12]([CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20][NH:21][c:22]1[n:23][c:24]([cH:25][c:26]([n:27]1)[N:28]1[CH2:29][CH2:30][N:31]([CH2:32][CH2:33]1)[CH2:48][CH2:49][P:50](=[O:51])([O:52][CH2:53][CH3:54])[O:55][CH2:56][CH3:57])[NH2:34])[C:35](=[O:36])[O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[CH:42]1[CH2:43][CH2:44][CH2:45][CH2:46][CH2:47]1|US09045441B2_0619
3.9.24|[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl.[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#12]-Br>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][CH:2]([CH3:3])[CH2:4][N:5]([CH:6]=[N:7][S:8](=[O:9])(=[O:10])[c:11]1[c:12]([n:13][c:14]2[n:15]1[n:16][c:17]([cH:18][cH:19]2)Cl)[Cl:20])[CH2:21][CH:22]([CH3:23])[CH3:24].Br[Mg][CH:25]1[CH2:26][CH2:27]1>Cl[Ni]1([P](CCC[P]1(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1)Cl.C1CCOC1.BrC1CC1.Cl[Zn]Cl.II.Cl.[Mg]>[CH3:1][CH:2]([CH3:3])[CH2:4][N:5]([CH:6]=[N:7][S:8](=[O:9])(=[O:10])[c:11]1[c:12]([n:13][c:14]2[n:15]1[n:16][c:17]([cH:18][cH:19]2)[CH:25]1[CH2:26][CH2:27]1)[Cl:20])[CH2:21][CH:22]([CH3:23])[CH3:24]|US20170355712A1_1059
3.11.1|[C:6]-[C&H2&+0&D2:5]-[O:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[O:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[O:1]=[C:2]1[CH2:3][O:4][CH2:5][CH2:6][NH:7]1.[O:8]=[CH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>O.CCCCCC.CCCC[Li].C1CCOC1>[O:1]=[C:2]1[NH:7][CH2:6][CH2:5][O:4][CH:3]1[CH:9]([OH:8])[c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US20050020684A1_1613
1.2.17|[C&H1&+0&D1:6]#[C&H0&+0&D2:5]-[c:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H1&+0&D2:6](=[C&H1&+0&D2:5]-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH:1]#[C:2][c:3]1[cH:4][n:5][c:6]([n:7][cH:8]1)[CH3:9].[CH3:10][N:11]1[CH:12]2[CH2:13][CH2:14][CH:15]1[CH2:16][c:17]1[nH:18][c:19]3[cH:20][cH:21][cH:22][cH:23][c:24]3[c:25]12>O.CS(C)=O.Oc1ccc(cc1)O.[Na]>[CH3:9][c:6]1[n:5][cH:4][c:3]([cH:8][n:7]1)[CH:2]=[CH:1][n:18]1[c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[c:25]2[c:17]1[CH2:16][CH:15]1[CH2:14][CH2:13][CH:12]2[N:11]1[CH3:10]|US09063126B2_0839
9.7.52|[N&H4&+&D0:5].[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[N&H2&+0&D1:5]-[S&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[NH4+:1].[CH3:2][C:3](=[CH:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[S:11](=[O:12])(=[O:13])Cl.[OH-]>>[CH3:2][C:3](=[CH:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[S:11]([NH2:1])(=[O:12])=[O:13]|US20200291003A1_0670
1.9.20|[C:6]-[O&H1&+0&D1:5].[O&H0&D1:4]=[P&H0&+0&D4:3](-[O:2])(-[O:1])-O>>[C:6]-[O&H0&+0&D2:5]-[P&H0&+0&D4:3](=[O&H0&D1:4])(-[O:2])-[O:1]|[Cl-].[CH:1]#[C:2][CH2:3][OH:4].[CH3:5][O:6][P:7](=[O:8])(O)[O:9][CH3:10]>>[CH:1]#[C:2][CH2:3][O:4][P:7](=[O:8])([O:6][CH3:5])[O:9][CH3:10]|US08481551B2_0211
1.9.20|[C:6]-[P&H0&+0&D4:5](=[O&H0&D1:4])(-[O:3])-O.[O&H1&+0&D1:2]-[c:1]>>[C:6]-[P&H0&+0&D4:5](=[O&H0&D1:4])(-[O&H0&+0&D2:2]-[c:1])-[O:3]|[Cl-].[CH2:1]=[CH:2][CH2:3][P:4](=[O:5])(O)[O:6][CH2:7][CH3:8].[OH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>>[CH2:1]=[CH:2][CH2:3][P:4](=[O:5])([O:6][CH2:7][CH3:8])[O:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US04257987A
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH2:1]=[CH:2][c:3]1[n:4][o:5][c:6]([n:7]1)[CH3:8].[CH3:9][n:10]1[c:11]([n:12]([c:13]2[n:14][cH:15][nH:16][c:17]2[c:18]1=[O:19])[CH3:20])=[O:21]>CN(C)C=O>[CH3:8][c:6]1[n:7][c:3]([n:4][o:5]1)[CH2:2][CH2:1][n:16]1[cH:15][n:14][c:13]2[c:17]1[c:18]([n:10]([c:11]([n:12]2[CH3:20])=[O:21])[CH3:9])=[O:19]|US20120245161A1_0711
2.5.5|[C:6]-[N&H1&+0&D2:5]-[C:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[N&H1&+0&D1:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]1[CH2:8][CH2:9][N:10]([CH2:11][CH2:12]1)[C:13](=[O:14])[C:15]([CH3:16])([CH3:17])[CH:18]([CH2:19][CH3:20])[NH:21][C:22](=[O:23])[c:24]1[cH:25][cH:26][c:27]([cH:28][c:29]1[F:30])[C:31]#[N:32].[CH2:33]1[CH2:34][CH2:35][NH:36][CH2:37][CH2:38]1>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]1[CH2:8][CH2:9][N:10]([CH2:11][CH2:12]1)[C:13](=[O:14])[C:15]([CH3:16])([CH3:17])[CH:18]([CH2:19][CH3:20])[NH:21][C:22](=[O:23])[c:24]1[cH:25][cH:26][c:27]([cH:28][c:29]1[F:30])[C:31](=[NH:32])[N:36]1[CH2:35][CH2:34][CH2:33][CH2:38][CH2:37]1|US20130023563A1_0334
3.11.42|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O-C.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][C:7]([C:8]#[N:9])([CH2:10][CH2:11][C:12](=[O:13])OC)[c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[Cl:20]>CC(=O)O.CC(C)(C)O[K].N#CC(CCC(=O)O)(CCC(=O)O)c1ccc(cc1)Cl.C1CCOC1>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][C:7]([CH2:10][CH2:11][C:12]1=[O:13])([C:8]#[N:9])[c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[Cl:20]|US20130012485A1_0322
2.1.2|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&-].[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[Na+].[CH3:1][C:2]([O-])=[O:3].[NH2:4][c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[N+:11]([O-:12])=[O:13])[S:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CC(=O)OC(C)=O.O=S(=O)(O)O>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[N+:11]([O-:12])=[O:13])[S:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|US20200165256A1_0522
2.6.2|[C&H3&D1:5]-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[O&-]>>[C&H3&D1:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[Na+].[CH3:1][OH:2].[O-][C:3](=[O:4])[CH:5]([S:6][CH2:7][c:8]1[cH:9][cH:10][n:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>Cl>[CH3:1][O:2][C:3](=[O:4])[CH:5]([S:6][CH2:7][c:8]1[cH:9][cH:10][n:11][cH:12][cH:13]1)[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|EP3656782A1_0320
2.1.2|[C&H3&D1:5]-[N&H2&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[O&-]>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[O-][C:1](=[O:2])[CH:3]([c:4]1[cH:5][cH:6][cH:7][c:8]([n:9]1)[Br:10])[N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1.[CH3:17][NH2:18].Cl.[K+]>On1nnc2ccccc21.CC(C)N(CC)C(C)C.CN(C)C=O.ClCCCl.O>[CH3:17][NH:18][C:1](=[O:2])[CH:3]([c:4]1[cH:5][cH:6][cH:7][c:8]([n:9]1)[Br:10])[N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1|US20200079777A1_3476
1.2.16|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[C:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:5][c:6]2[c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[nH:13][c:14]2[CH2:15][CH2:16]1.[CH2:17]=[CH:18][C:19](=[O:20])[O:21][CH2:22][CH3:23]>C[N+](C)(C)Cc1ccccc1.c1ccccc1.CCO.CO.Cl.[OH-]>[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:5][c:6]2[c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[n:13]([c:14]2[CH2:15][CH2:16]1)[CH2:17][CH2:18][C:19](=[O:20])[O:21][CH2:22][CH3:23]|US20180265479A1_0150
2.6.8|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&-].[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[Na+].[CH3:1][C:2]1=[CH:3][C:4]([CH2:5][CH:6]([CH2:7]1)[OH:8])([CH3:9])[CH3:10].[CH3:11][C:12]([O-])=[O:13]>[Na+].CO.CC(=O)OC(C)=O.CC1=CC(CC(C1)=O)(C)C.[BH4-]>[CH3:1][C:2]1=[CH:3][C:4]([CH2:5][CH:6]([CH2:7]1)[O:8][C:12]([CH3:11])=[O:13])([CH3:9])[CH3:10]|EP0003884A2_0040
10.2.1|[N&H2&+0&D1:5]-[c:4].[O&H0&-&D1:3]-[N&H0&+&D3:2](=[O&H0&D1:1])-O>>[N&H1&+0&D2:5](-[c:4])-[N&H0&+&D3:2](-[O&H0&-&D1:3])=[O&H0&D1:1]|[NH2:1][c:2]1[c:3]([cH:4][c:5]([cH:6][c:7]1[I:8])[Cl:9])[Br:10].[O-:11][N+:12](=[O:13])O>O.CC(=O)O.CC(=O)OC(C)=O>[O-:11][N+:12](=[O:13])[NH:1][c:2]1[c:3]([cH:4][c:5]([cH:6][c:7]1[I:8])[Cl:9])[Br:10]|US20090270431A1_0213
1.2.17|[C&H1&+0&D1:6]#[C&H0&+0&D2:5]-[C:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H1&+0&D2:6](=[C&H1&+0&D2:5]\[C:4])\[n&H0&+0&D3:2](:[c:3]):[n:1]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([cH:10]1)-[c:11]1[n:12][cH:13][nH:14][n:15]1)[C:16]([F:17])([F:18])[F:19].[CH:20]#[C:21][C:22](=[O:23])[O:24][CH:25]([CH3:26])[CH3:27]>>[CH3:26][CH:25]([CH3:27])[O:24][C:22](=[O:23])/[CH:21]=[CH:20]\[n:14]1[cH:13][n:12][c:11]([n:15]1)-[c:9]1[cH:10][c:5]([cH:6][c:7]([cH:8]1)[C:16]([F:17])([F:18])[F:19])[C:2]([F:1])([F:3])[F:4]|
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[S:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[S:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH2:1]=[CH:2][S:3](=[O:4])(=[O:5])[C:6]1([CH2:7][N:8]([CH2:9][CH2:10][CH2:11]1)[C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[C:19](=[O:20])[NH:21][C@@H:22]([CH2:23][c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)-[c:30]1[c:31]([cH:32][cH:33][cH:34][c:35]1[O:36][CH3:37])[O:38][CH3:39])[C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46].[cH:47]1[cH:48][nH:49][cH:50][n:51]1>C1CN=C2CCCCCN2C1.CC#N>[CH3:16][C:15]([CH3:17])([CH3:18])[O:14][C:12](=[O:13])[N:8]1[CH2:9][CH2:10][CH2:11][C:6]([CH2:7]1)([C:19](=[O:20])[NH:21][C@@H:22]([CH2:23][c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)-[c:30]1[c:31]([cH:32][cH:33][cH:34][c:35]1[O:36][CH3:37])[O:38][CH3:39])[C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[S:3](=[O:4])(=[O:5])[CH2:2][CH2:1][n:49]1[cH:50][n:51][cH:47][cH:48]1|US20120071669A1_0130
2.1.2|[C&H3&D1:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O-][C:1](=[O:2])[c:3]1[cH:4][cH:5][c:6]2[O:7][C:8]([O:9][c:10]2[cH:11]1)([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[CH3:24][NH2:25].[Li+]>CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.CN(C)C=O>[CH3:24][NH:25][C:1](=[O:2])[c:3]1[cH:4][cH:5][c:6]2[O:7][C:8]([O:9][c:10]2[cH:11]1)([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1|US20200385375A1_0511
9.7.52|[N&H4&+&D0:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[N&H2&+0&D1:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[NH4+:1].[O:2]=[C:3]([OH:4])[c:5]1[cH:6][c:7]([c:8]([c:9]([cH:10]1)[S:11](=[O:12])(=[O:13])Cl)-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[NH:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[OH-]>Cl>[NH2:1][S:11](=[O:12])(=[O:13])[c:9]1[cH:10][c:5]([cH:6][c:7]([c:8]1-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[NH:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[C:3](=[O:2])[OH:4]|EP3656771A1_0990
2.5.5|[C:6]-[C&H0&+0&D2:5]#[N&H0&+0&D1:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[N&H1&+0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[ClH:1].[N:2]#[C:3][CH2:4][Cl:5].[NH2:6][C:7](=[O:8])[O:9][C@@H:10]1[CH2:11][CH2:12][NH:13][CH2:14]1>CO.[Na]>[ClH:1].[NH:2]=[C:3]([CH2:4][Cl:5])[N:13]1[CH2:12][CH2:11][C@H:10]([CH2:14]1)[O:9][C:7]([NH2:6])=[O:8]|EP1176141A1_0077
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[C:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&+0&D1:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH2:1]=[CH:2][C:3](=[O:4])[O:5][CH2:6][CH3:7].[Cl:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[N:15]1[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1>CCO>[CH3:7][CH2:6][O:5][C:3](=[O:4])[CH:2]([CH3:1])[N:18]1[CH2:19][CH2:20][N:15]([CH2:16][CH2:17]1)[c:13]1[cH:14][c:9]([cH:10][cH:11][cH:12]1)[Cl:8]|US20150240295A1_0275
3.11.1|[C:6]-[C&H2&+0&D2:5]-[N:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[N:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][NH:11][C:12]([CH2:13]1)=[O:14].[O:15]=[CH:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23]>CC(C)NC(C)C.CCCCCC.CCCC[Li].C1CCOC1.O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][NH:11][C:12]([CH:13]1[CH:16]([OH:15])[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23])=[O:14]|EP2801573A1_0076
3.11.1|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][CH:9](/[CH:10]=[CH:11]/[CH:12]1[CH2:13][CH2:14][CH:15]2[C:16]([CH2:17][CH2:18][CH:19]21)=[O:20])[CH2:21][O:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[CH3:29][O:30][C:31](=[O:32])[CH2:33][CH2:34][CH2:35][CH:36]=[O:37]>C[Si](C)(C)[N-][Si](C)(C)C.CCOCC.C1CCOC1.CC(=O)O.O.[Li+]>[CH3:29][O:30][C:31](=[O:32])[CH2:33][CH2:34][CH2:35][CH:36]([OH:37])[CH:17]1[CH2:18][CH:19]2[CH:15]([CH2:14][CH2:13][CH:12]2/[CH:11]=[CH:10]/[CH:9]([CH2:21][O:22][c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[O:8][Si:5]([CH3:6])([CH3:7])[C:2]([CH3:1])([CH3:3])[CH3:4])[C:16]1=[O:20]|US04833169A
3.11.38|[C&H1&+0&D1:5]#[C:4].[C&H3&D1:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H0&+0&D2:5](#[C:4])-[C&H1&+0&D3:2](-[C&H3&D1:3])-[O&H1&+0&D1:1]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[CH3:9][CH:10]=[O:11]>CCCCCC.CCOCC.CCCC[Li].C1CCOC1>[CH3:9][CH:10]([OH:11])[C:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|US10815246B2_0352
2.5.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-S-C>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][NH:2][CH2:3][CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21].CS[c:22]1[n:23][c:24]([c:25]([cH:26][nH:27]1)[CH2:28][c:29]1[cH:30][n:31][cH:32][n:33][cH:34]1)=[O:35]>CCO>[CH3:1][N:2]([CH2:3][CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21])[c:22]1[n:23][c:24]([c:25]([cH:26][nH:27]1)[CH2:28][c:29]1[cH:30][n:31][cH:32][n:33][cH:34]1)=[O:35]|US08822451B2_0218
1.2.16|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[C:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:16][CH2:17][C:18]1([NH:19][C:20]([NH:21][C:22]1=[O:23])=[O:24])[CH3:25].[CH2:26]=[CH:27][C:28](=[O:29])[O:30][CH2:31][CH3:32]>C[N+](C)(C)Cc1ccccc1.CC(=O)O.CCO.CO.O.[OH-]>[CH3:13][C:12]([CH3:14])([CH3:15])[c:9]1[cH:8][c:7]([cH:6][c:5]([c:10]1[OH:11])[C:2]([CH3:1])([CH3:3])[CH3:4])[CH2:16][CH2:17][C:18]1([NH:19][C:20]([N:21]([C:22]1=[O:23])[CH2:26][CH2:27][C:28](=[O:29])[O:30][CH2:31][CH3:32])=[O:24])[CH3:25]|EP3541786B1_0384
3.11.1|[C:6]-[C&H2&+0&D2:5]-[C:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][C:2]1([CH2:3][C:4]([CH2:5][C:6]([NH:7]1)([CH3:8])[CH3:9])=[O:10])[CH3:11].[CH3:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[CH:19]=[O:20]>CCCCCC.CCOCC.CCCC[Li].Cl>[CH3:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[CH:19]([OH:20])[CH:3]1[C:4]([CH2:5][C:6]([NH:7][C:2]1([CH3:1])[CH3:11])([CH3:8])[CH3:9])=[O:10]|EP0412350A2_0108
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[C:4].[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[C:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH2:1]=[CH:2][C:3]#[N:4].[O:5]=[C:6]1[NH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[C:14]1([OH:15])[c:16]1[cH:17][c:18]([cH:19][cH:20][cH:21]1)[Cl:22]>CCO.C>[N:4]#[C:3][CH2:2][CH2:1][N:7]1[C:6]([C:14]([c:13]2[cH:12][cH:11][cH:10][cH:9][c:8]21)([OH:15])[c:16]1[cH:21][cH:20][cH:19][c:18]([cH:17]1)[Cl:22])=[O:5]|US20200261436A1_0480
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH2:1]=[CH:2][c:3]1[cH:4][cH:5][n:6][cH:7][cH:8]1.[O:9]=[C:10]([NH:11][CH:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>CO.CC(=O)O>[O:9]=[C:10]([NH:11][CH:12]1[CH2:13][CH2:14][N:15]([CH2:16][CH2:17]1)[CH2:1][CH2:2][c:3]1[cH:4][cH:5][n:6][cH:7][cH:8]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|EP3328853B1_0435
1.9.20|[C:6]-[P&H0&+0&D4:5](-[C:4])(=[O&H0&D1:3])-O.[C:2]-[O&H1&+0&D1:1]>>[C:6]-[P&H0&+0&D4:5](-[C:4])(=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][P:10](=[O:11])(O)[CH2:12][NH:13][C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20].[CH3:21][CH2:22][OH:23]>C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][P:10](=[O:11])([CH2:12][NH:13][C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[O:23][CH2:22][CH3:21]|US20110213062A1_0263
2.5.5|[C:6]-[N&H1&+0&D2:5]-[C:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[N:1]>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[N&H1&+0&D1:3])-[N:1]|[CH3:1][S:2](=[O:3])(=[O:4])[N:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1.[N:11]#[C:12][NH:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1-[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>CCO>[CH3:1][S:2](=[O:3])(=[O:4])[N:5]1[CH2:6][CH2:7][N:8]([CH2:9][CH2:10]1)[C:12](=[NH:11])[NH:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1-[c:20]1[cH:25][cH:24][cH:23][cH:22][cH:21]1|US10493061B2_0465
1.2.19|[C:6]-[C&H2&+0&D2:5]-[C&H1&+0&D2:4]=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][CH:5]=O.[CH2:6]1[CH2:7][NH:8][CH2:9][CH2:10][O:11]1>C1CCCCC1.O>[CH3:1][CH:2]([CH3:3])[CH:4]=[CH:5][N:8]1[CH2:9][CH2:10][O:11][CH2:6][CH2:7]1|US07718828B2_0023
1.9.20|[C:6]-[O&H1&+0&D1:5].[C:4]-[P&H0&+0&D4:3](=[O&H0&D1:2])(-[O:1])-O>>[C:6]-[O&H0&+0&D2:5]-[P&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])-[O:1]|[CH3:1][CH2:2][O:3][P:4](=[O:5])(O)[CH2:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[C:13]([F:14])([F:15])[F:16].[OH:17][CH2:18][CH2:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>CCOP(=O)(Cc1cccc(c1)C(F)(F)F)OCl.CCN(CC)CC.CN(C)C=O.C(C#[O+])#[O+].ClCCl.[Cl-].[Cl-]>[CH3:1][CH2:2][O:3][P:4](=[O:5])([CH2:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[C:13]([F:14])([F:15])[F:16])[O:17][CH2:18][CH2:19][CH2:20][c:21]1[cH:26][cH:25][cH:24][cH:23][cH:22]1|US09133224B2_0697
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[S:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[S:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH2:1]=[CH:2][S:3](=[O:4])(=[O:5])[N:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[O:12][c:13]1[cH:14][cH:15][c:16]([c:17]([cH:18]1)[O:19][CH3:20])[CH2:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][N:27]([CH2:28][CH:29]1[C:30]([NH2:31])=[O:32])[c:33]1[cH:34][cH:35][cH:36][cH:37][c:38]1[CH3:39].[CH3:40][CH2:41][NH:42][CH2:43][CH3:44]>CO>[CH3:20][O:19][c:17]1[cH:18][c:13]([cH:14][cH:15][c:16]1[CH2:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][N:27]([CH2:28][CH:29]1[C:30]([NH2:31])=[O:32])[c:33]1[cH:34][cH:35][cH:36][cH:37][c:38]1[CH3:39])[O:12][CH:9]1[CH2:8][CH2:7][N:6]([CH2:11][CH2:10]1)[S:3](=[O:4])(=[O:5])[CH2:2][CH2:1][N:42]([CH2:43][CH3:44])[CH2:41][CH3:40]|EP1987042B1_0259
1.2.17|[C&H1&+0&D1:6]#[C&H0&+0&D2:5]-[S:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H1&+0&D2:6](=[C&H1&+0&D2:5]/[S:4])\[n&H0&+0&D3:2](:[c:3]):[n:1]|Cl.[CH:1]#[C:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH3:12].[O:13]=[c:14]1[nH:15][n:16][n:17][n:18]1-[c:19]1[cH:20][cH:21][cH:22][n:23][cH:24]1>CC#N.C1CN2CCC1NC2>[CH3:12][c:9]1[cH:10][cH:11][c:6]([cH:7][cH:8]1)[S:3](=[O:4])(=[O:5])/[CH:2]=[CH:1]/[n:15]1[n:16][n:17][n:18]([c:14]1=[O:13])-[c:19]1[cH:24][n:23][cH:22][cH:21][cH:20]1|US10844040B2_0634
2.6.8|[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&-].[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[Na+].[Na+:1].[CH3:2][C:3]([O-])=[O:4].[CH3:5][CH2:6][O:7][C:8](=[O:9])[C:10]([c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[O:17][S:18]([O-:19])(=[O:20])=[O:21])([c:22]1[cH:23][cH:24][cH:25][cH:26][n:27]1)[c:28]1[cH:29][cH:30][c:31]([cH:32][cH:33]1)[OH:34]>CC(=O)OC(C)=O>[Na+:1].[CH3:5][CH2:6][O:7][C:8](=[O:9])[C:10]([c:22]1[cH:23][cH:24][cH:25][cH:26][n:27]1)([c:28]1[cH:29][cH:30][c:31]([cH:32][cH:33]1)[O:34][C:3]([CH3:2])=[O:4])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[O:17][S:18]([O-:19])(=[O:20])=[O:21]|US20190071574A1_0075
3.11.52|[Br&H0&D1:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[Br&H0&D1:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]([C:6]#[N:7])[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[O:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[Br:21][CH2:22]Br>O.CS(C)=O.O[Na]>[CH3:1][CH2:2][CH2:3][CH2:4][C:5]([C:6]#[N:7])([CH2:22][Br:21])[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[O:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20180244611A1_1342
1.9.20|[O&H0&D1:6]=[P&H0&+0&D4:5](-[O:4])(-[O:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[O&H0&D1:6]=[P&H0&+0&D4:5](-[O&H0&+0&D2:2]-[c:1])(-[O:4])-[O:3]|[CH3:1][N:2]([CH3:3])[c:4]1[n:5][c:6]([cH:7][c:8]([n:9]1)[OH:10])[C:11]([F:12])([F:13])[F:14].[CH3:15][CH2:16][O:17][P:18](=[O:19])(Cl)[O:20][CH2:21][CH3:22]>CCOC(C)=O.O=C(O[K])O[K]>[CH3:1][N:2]([CH3:3])[c:4]1[n:5][c:6]([cH:7][c:8]([n:9]1)[O:10][P:18](=[O:19])([O:17][CH2:16][CH3:15])[O:20][CH2:21][CH3:22])[C:11]([F:12])([F:13])[F:14]|US20180055816A1_0132
3.11.27|[C&H3&+0&D1:5]-[S&+](-C)-C.[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:5]1-[C&H1&+0&D3:3](-[C:4])-[C&H1&+0&D3:2]-1-[C:1]|[CH3:1][C@H:2]([CH:3]=[CH:4][C:5]#[N:6])[NH:7][C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14].C[S+](C)[CH3:15].[I-]>CC(=O)OCC.CS(C)=O.O.[NaH]>[CH3:1][C@@H:2]([NH:7][C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH:3]1[CH2:15][CH:4]1[C:5]#[N:6]|US06881728B1_0161
1.2.14|[C:6]-[N&H2&+0&D1:5].[C:4]-[C&H1&+0&D3:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C:6]-[N&H1&+0&D2:5]-[C&H1&+0&D3:3](-[C:4])-[C:2]-[O&H1&+0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][C:6]([CH3:7])([CH3:8])[NH2:9].[CH2:10]1[CH2:11][CH2:12][CH:13]2[O:14][CH:15]2[CH2:16]1>CN(C)C1CCCCC1.ClCCl.Cl[Zn]Cl>[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][C:6]([CH3:7])([CH3:8])[NH:9][CH:15]1[CH2:16][CH2:10][CH2:11][CH2:12][CH:13]1[OH:14]|US10329294B2_0602
1.6.4|[O:6]-[C&H2&+0&D2:5]-Cl.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[O:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1][C:2]1([S:3][C@@H:4]2[CH:5]([C:6]([N:7]2[CH:8]1[c:9]1[n:10][n:11][n:12][nH:13]1)=[O:14])[NH2:15])[CH3:16].[CH3:17][C:18]([CH3:19])([CH3:20])[C:21](=[O:22])[O:23][CH2:24]Cl>CCN(CC)CC.CN(C)C=O.O>[CH3:1][C:2]1([S:3][C@@H:4]2[CH:5]([C:6]([N:7]2[CH:8]1[c:9]1[n:10][n:11][n:12]([n:13]1)[CH2:24][O:23][C:21](=[O:22])[C:18]([CH3:17])([CH3:19])[CH3:20])=[O:14])[NH2:15])[CH3:16]|US10626095B2_3423
1.9.20|[C:6]-[O&H1&+0&D1:5].[O&H0&D1:4]=[P&H0&+0&D4:3](-[O:2])(-[O:1])-Cl>>[C:6]-[O&H0&+0&D2:5]-[P&H0&+0&D4:3](=[O&H0&D1:4])(-[O:2])-[O:1]|[CH3:1][CH2:2][O:3][P:4](=[O:5])(Cl)[O:6][CH2:7][CH3:8].[CH3:9][Si:10]([CH3:11])([CH3:12])[CH2:13][CH2:14][OH:15]>c1ccncc1.ClC(Cl)(Cl)Cl>[CH3:8][CH2:7][O:6][P:4](=[O:5])([O:3][CH2:2][CH3:1])[O:15][CH2:14][CH2:13][Si:10]([CH3:9])([CH3:11])[CH3:12]|US20190211060A1_0565
2.1.10|[N&H2&+0&D1:5]-[N:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-c1:c:c:c:c:c:1>>[N&H1&+0&D2:5](-[N:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][n:7][cH:8][cH:9]1)Oc1ccccc1.[NH2:10][N:11]1[CH2:12][CH:13]=[CH:14][CH2:15][CH2:16]1.Cl>CCN(CC)CC.ClC(Cl)Cl>[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][n:7][cH:8][cH:9]1)[NH:10][N:11]1[CH2:16][CH2:15][CH:14]=[CH:13][CH2:12]1|US20080064718A1_0615
1.2.14|[C:6]-[N&H1&+0&D2:5]-[C:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[OH:1][CH:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1.[cH:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[cH:15][c:16]([n:17][o:18]1)[CH:19]1[CH2:20][O:21]1>>[OH:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH2:20][CH:19]([OH:21])[c:16]1[cH:15][c:14]([o:18][n:17]1)-[c:11]1[cH:12][cH:13][cH:8][cH:9][cH:10]1|US04224333A
1.6.4|[c:6]-[C&H2&+0&D2:5]-Cl.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[c:1]>>[c:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1][CH:2]([CH3:3])[CH2:4][C:5](=[O:6])[c:7]1[cH:8][n:9][nH:10][c:11]1[C:12](=[O:13])[O:14][CH2:15][CH3:16].Cl[CH2:17][c:18]1[cH:19][cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]12>Cl.CN(C)C=O.O=C(O[Cs])O[Cs]>[CH3:16][CH2:15][O:14][C:12](=[O:13])[c:11]1[n:10][n:9]([cH:8][c:7]1[C:5](=[O:6])[CH2:4][CH:2]([CH3:1])[CH3:3])[CH2:17][c:18]1[cH:19][cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]21|US20180057505A1_0745
1.6.4|[C:6]-[C&H2&+0&D2:5]-Cl.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[c:1]>>[C:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:1]):[n&H0&+0&D2:3]:[c:4]|[N:1]#[C:2][CH2:3]Cl.[cH:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[cH:11][c:12]2[n:13][n:14][c:15]([n:16]2[n:17][c:18]1[O:19][CH2:20][c:21]1[n:22][cH:23][n:24][nH:25]1)-[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>O.CN(C)C=O.[NaH]>[N:1]#[C:2][CH2:3][n:24]1[cH:23][n:22][c:21]([n:25]1)[CH2:20][O:19][c:18]1[n:17][n:16]2[c:15]([n:14][n:13][c:12]2[cH:11][c:10]1-[c:7]1[cH:8][cH:9][cH:4][cH:5][cH:6]1)-[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1|US20200181144A1_0651
2.5.8|[C:6]-[N&H1&+0&D2:5]-[C:4].[N:3]=[C&H0&+0&D3:2](-[N:1])-O-c1:c:c:c:c:c:1>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[N:3])-[N:1]|[N:1]#[C:2][N:3]=[C:4]([NH:5][C@H:6]([CH2:7][c:8]1[cH:9][c:10]([c:11]([c:12]([cH:13]1)[Br:14])[NH2:15])[Br:16])[C:17](=[O:18])[N:19]1[CH2:20][CH2:21][CH:22]([CH2:23][CH2:24]1)[N:25]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1)Oc1ccccc1.[O:31]=[C:32]1[NH:33][c:34]2[cH:35][cH:36][cH:37][cH:38][c:39]2-[c:40]2[cH:41][cH:42][cH:43][cH:44][c:45]2[N:46]1[CH:47]1[CH2:48][CH2:49][NH:50][CH2:51][CH2:52]1>>[N:1]#[C:2][N:3]=[C:4]([NH:5][C@H:6]([CH2:7][c:8]1[cH:13][c:12]([c:11]([c:10]([cH:9]1)[Br:16])[NH2:15])[Br:14])[C:17](=[O:18])[N:19]1[CH2:20][CH2:21][CH:22]([CH2:23][CH2:24]1)[N:25]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1)[N:50]1[CH2:49][CH2:48][CH:47]([CH2:52][CH2:51]1)[N:46]1[C:32]([NH:33][c:34]2[cH:35][cH:36][cH:37][cH:38][c:39]2-[c:40]2[c:45]1[cH:44][cH:43][cH:42][cH:41]2)=[O:31]|US20080076924A1_0999
1.6.4|[O:6]-[C&H2&+0&D2:5]-Cl.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[c:1]>>[O:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1][CH2:2][O:3][CH2:4]Cl.[CH3:5][S:6][c:7]1[n:8][cH:9][n:10][nH:11]1>Cc1ccccc1>[CH3:1][CH2:2][O:3][CH2:4][n:10]1[cH:9][n:8][c:7]([n:11]1)[S:6][CH3:5]|US20200165280A1_0196
1.6.2|[c:6]-[C&H2&+0&D2:5]-Br.[n:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[c:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[n:4]|[CH3:1][c:2]1[n:3][cH:4][c:5]([c:6]2[CH2:7][O:8][C:9]([O:10][c:11]12)([CH3:12])[CH3:13])[CH2:14]Br.[cH:15]1[n:16][n:17][nH:18][n:19]1>>[CH3:12][C:9]1([O:8][CH2:7][c:6]2[c:11]([O:10]1)[c:2]([n:3][cH:4][c:5]2[CH2:14][n:17]1[n:16][cH:15][n:19][n:18]1)[CH3:1])[CH3:13]|US20170008877A1_3073
1.9.20|[C:6]-[O&H1&+0&D1:5].[N:4]-[P&H0&+0&D4:3](=[O&H0&D1:2])(-[O:1])-Cl>>[C:6]-[O&H0&+0&D2:5]-[P&H0&+0&D4:3](-[N:4])(=[O&H0&D1:2])-[O:1]|[CH2:1]=[CH:2][CH2:3][N:4]1[C:5]([S:6][CH:7]([C:8]1=[O:9])[OH:10])=[N:11][N:12]=[C:13]1[S:14][CH2:15][C:16]([N:17]1[CH3:18])=[O:19].[CH3:20][N:21]1[CH2:22][CH2:23][O:24][P:25]1(=[O:26])Cl>CCN(CC)CC.ClCCl>[CH2:1]=[CH:2][CH2:3][N:4]1[C:5]([S:6][CH:7]([C:8]1=[O:9])[O:10][P:25]1([O:24][CH2:23][CH2:22][N:21]1[CH3:20])=[O:26])=[N:11][N:12]=[C:13]1[S:14][CH2:15][C:16]([N:17]1[CH3:18])=[O:19]|US20170334941A1_0252
2.1.17|[N&H2&+0&D1:5]-[S:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O-c1:c:c:c:c:c:1>>[N&H1&+0&D2:5](-[S:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[O:17]=[C:18](Oc1ccccc1)[O:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>O.Cl.CN(C)C=O.[NaH]>[O:17]=[C:18]([NH:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[O:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US20190119224A1_1718
3.11.57|[C&H2&+0&D1:5]=[N&+]=[N&-].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H2&+0&D2:5]1-[C&H1&+0&D3:2](-[c:1])-[C&H1&+0&D3:3]-1-[C:4]|[CH3:1][O:2][C:3](=[O:4])[CH:5]=[CH:6][c:7]1[cH:8][cH:9][c:10]([s:11]1)[C:12](=[O:13])[NH:14][CH2:15][C@H:16]([NH:17][C:18](=[O:19])[O:20][CH2:21][C:22]12[CH2:23][CH:24]3[CH2:25][CH:26]([CH2:27][CH:28]([CH2:29]3)[CH2:30]1)[CH2:31]2)[C:32](=[O:33])[O:34][C:35]([CH3:36])([CH3:37])[CH3:38].[CH2:39]=[N+]=[N-]>CC(=O)O[Pd]OC(C)=O.CCOCC>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:39][CH:6]1[c:7]1[cH:8][cH:9][c:10]([s:11]1)[C:12](=[O:13])[NH:14][CH2:15][C@H:16]([NH:17][C:18](=[O:19])[O:20][CH2:21][C:22]12[CH2:23][CH:24]3[CH2:25][CH:26]([CH2:27][CH:28]([CH2:29]3)[CH2:30]1)[CH2:31]2)[C:32](=[O:33])[O:34][C:35]([CH3:36])([CH3:37])[CH3:38]|US09815819B2_0558
1.2.14|[C:6]-[C&H1&+0&D3:5]1-[C:4]-[O&H0&+0&D2:3]-1.[N&H2&+0&D1:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[N&H1&+0&D2:2]-[c:1])-[C:4]-[O&H1&+0&D1:3]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[CH2:8]1[CH2:9][CH:10]2[O:11][CH:12]2[CH2:13]1>>[OH:11][CH:10]1[CH2:9][CH2:8][CH2:13][CH:12]1[NH:1][c:2]1[cH:7][cH:6][cH:5][cH:4][cH:3]1|US20180265497A1_1797
1.2.14|[C:6]-[N&H1&+0&D2:5]-[c:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[O:1]=[C:2]1[CH2:3][C:4]([N:5]([c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[NH:12]1)[Cl:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)=[O:20].[CH2:21]1[CH2:22][O:23]1>O.CO.C[N+](C)(C)Cc1ccccc1.[OH-]>[O:1]=[C:2]1[CH2:3][C:4]([N:5]([c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[N:12]1[CH2:22][CH2:21][OH:23])[Cl:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)=[O:20]|US20180265497A1_1864
4.3.11|[C:6]-[C&H0&+0&D2:5]#N.[N&H2&+0&D1:4]-[c:3]:[c:2]-[S&H1&+0&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[s&H0&+0&D2:1]:1|Cl.[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[n:8][n:9]([c:10]([c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]12)=[O:17])[CH2:18][C:19]#N.[NH2:20][c:21]1[cH:22][c:23]([cH:24][c:25]([c:26]1[SH:27])[F:28])[F:29]>CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[n:8][n:9]([c:10]([c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]12)=[O:17])[CH2:18][c:19]1[n:20][c:21]2[cH:22][c:23]([cH:24][c:25]([c:26]2[s:27]1)[F:28])[F:29]|EP0313202A2_0018
1.7.17|[C:6]-[C&H1&+0&D3:5]1-[C:4]-[O&H0&+0&D2:3]-1.[O&H1&+0&D1:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[O&H0&+0&D2:2]-[c:1])-[C:4]-[O&H1&+0&D1:3]|[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH2:15]1[CH2:16][CH:17]2[O:18][CH:19]2[CH2:20]1>CCCCCC.CCOCC.O[K]>[OH:18][CH:19]1[CH2:20][CH2:15][CH2:16][CH:17]1[O:1][c:2]1[cH:7][cH:6][c:5]([cH:4][cH:3]1)[O:8][c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1|US20090247618A1_0211
2.1.17|[N&H2&+0&D1:5]-[S:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[n:1])-O-c1:c:c:c:c:c:1>>[N&H1&+0&D2:5](-[S:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[n:1]|[CH3:1][CH2:2][O:3][c:4]1[n:5][n:6]([c:7]([n:8]1[CH3:9])=[S:10])[C:11](=[O:12])Oc1ccccc1.[NH2:13][S:14](=[O:15])(=[O:16])[c:17]1[c:18]([cH:19][cH:20][cH:21][c:22]1[C:23]1=[N:24][O:25][CH2:26][CH2:27][O:28]1)[F:29]>Oc1ccccc1>[CH3:1][CH2:2][O:3][c:4]1[n:5][n:6]([c:7]([n:8]1[CH3:9])=[S:10])[C:11](=[O:12])[NH:13][S:14](=[O:15])(=[O:16])[c:17]1[c:18]([cH:19][cH:20][cH:21][c:22]1[C:23]1=[N:24][O:25][CH2:26][CH2:27][O:28]1)[F:29]|US07855166B2_0300
2.8.3|[C:6]-[N&H2&+0&D1:5].[O&H0&D1:4]=[P&H0&+0&D4:3](-[O:2])(-[O:1])-Cl>>[C:6]-[N&H1&+0&D2:5]-[P&H0&+0&D4:3](=[O&H0&D1:4])(-[O:2])-[O:1]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C@@H:11]([OH:12])[C@H:13]([NH2:14])[CH2:15][F:16].[CH3:17][O:18][P:19](=[O:20])(Cl)[O:21][CH3:22]>CCN(CC)CC.CC(Cl)Cl.CC#N.ClCCl>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C@@H:11]([OH:12])[C@@H:13]([CH2:15][F:16])[NH:14][P:19](=[O:20])([O:21][CH3:22])[O:18][CH3:17]|EP0376040A2_0256
10.1.1|[Br&H0&+0&D1:5]-Br.[C&H3&D1:4]-[C&H1&+0&D3:3](-[C&H3&D1:2])-[C:1]>>[Br&H0&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C&H3&D1:2])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([c:8]1[Cl:9])[Cl:10])[C:11](=[O:12])[CH:13]([CH3:14])[CH3:15].[Br:16]Br>O.CC(=O)O.O=S(O)O[Na]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([c:8]1[Cl:9])[Cl:10])[C:11](=[O:12])[C:13]([CH3:14])([CH3:15])[Br:16]|US20200102279A1_0054
1.6.2|[C:6]-[C&H2&+0&D2:5]-Br.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[C:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]Br.[cH:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)-[c:17]1[n:18][n:19][nH:20][c:21]1-[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>CCC(C)=O.O=C(O[K])O[K]>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][n:19]1[n:20][c:21]([c:17]([n:18]1)-[c:14]1[cH:15][cH:16][cH:11][cH:12][cH:13]1)-[c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1|EP3126336B1_0168
4.2.20|[C:6]-[C&H1&+0&D2:5]=O.[O&H1&+0&D1:4]-[C:3]-[C:2]-[O&H1&+0&D1:1]>>[C:6]-[C&H1&+0&D3:5]1-[O&H0&+0&D2:4]-[C:3]-[C:2]-[O&H0&+0&D2:1]-1|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[C:9]([OH:10])([CH2:11][OH:12])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.O=[CH:19][C:20]([Cl:21])([Cl:22])[Cl:23]>>[O:1]=[C:2]([c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1)[C:9]1([CH2:11][O:12][CH:19]([O:10]1)[C:20]([Cl:21])([Cl:22])[Cl:23])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US09109068B2_0283
4.1.45|[C:6]-[C&H1&+0&D2:5]=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1|[CH3:1][CH:2]([CH3:3])[CH2:4][C@H:5]([NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[NH:19][CH:20]([CH:21]=O)[CH2:22][CH2:23][CH2:24][CH3:25].[NH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][c:32]1[NH2:33]>CO.CC(=O)O>[CH3:25][CH2:24][CH2:23][CH2:22][CH:20]([NH:19][C:17](=[O:18])[C@H:5]([CH2:4][CH:2]([CH3:1])[CH3:3])[NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:21]1[n:33][c:32]2[cH:31][cH:30][cH:29][cH:28][c:27]2[nH:26]1|US20200331888A1_0803
1.2.14|[c:6]:[n&H1&+0&D2:5]:[c:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[c:6]:[n&H0&+0&D3:5](:[c:4])-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[CH2:1]=[C:2]([CH3:3])[n:4]1[c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[nH:11][c:12]1=[O:13])[CH3:14].[CH2:15]1[CH2:16][O:17]1>[Na+].CCO.C[O-]>[CH2:1]=[C:2]([CH3:3])[n:4]1[c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[n:11]([c:12]1=[O:13])[CH2:16][CH2:15][OH:17])[CH3:14]|US09688615B2_0356
1.6.2|[c:6]-[C&H2&+0&D2:5]-Br.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[c:1]>>[c:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:1]):[n&H0&+0&D2:3]:[c:4]|[NH2:1][c:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[n:9][c:10]2[CH2:11][CH2:12][c:13]3[cH:14][n:15][nH:16][c:17]3-[c:18]21.Br[CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>[Na+].CN(C)C=O.[H-]>[NH2:1][c:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[n:9][c:10]2[CH2:11][CH2:12][c:13]3[cH:14][n:15]([n:16][c:17]3-[c:18]21)[CH2:19][c:20]1[cH:25][cH:24][cH:23][cH:22][cH:21]1|EP3375780B1_0308
9.7.52|[N&H3&+0&D0:5].[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[N&H2&+0&D1:5]-[S&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[NH3:1].[O:2]=[S:3](=[O:4])(Cl)[CH:5]=[CH:6][c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[Cl:13])[Cl:14]>CCOCC>[NH2:1][S:3](=[O:2])(=[O:4])[CH:5]=[CH:6][c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[Cl:13])[Cl:14]|US20200291003A1_0745
1.6.2|[c:6]-[C&H2&+0&D2:5]-Br.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[c:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[Cl:14])[CH2:15]Br.[cH:16]1[cH:17][nH:18][n:19][n:20]1>CN(C)C=O.O.[H][H].[NaH]>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[Cl:14])[CH2:15][n:19]1[n:20][cH:16][cH:17][n:18]1|EP0921800B1_0439
1.6.4|[C:6]-[C&H2&+0&D2:5]-Cl.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[C:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|Cl.[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH2:6]Cl.[O:7]=[C:8]1[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[S:15]([c:16]2[cH:17][c:18]([cH:19][cH:20][c:21]12)-[c:22]1[n:23][n:24][n:25][nH:26]1)(=[O:27])=[O:28]>CCO.[Na]>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][CH2:6][n:25]1[n:24][n:23][c:22]([n:26]1)-[c:18]1[cH:19][cH:20][c:21]2[C:8]([c:9]3[cH:10][cH:11][cH:12][cH:13][c:14]3[S:15]([c:16]2[cH:17]1)(=[O:27])=[O:28])=[O:7]|US20060063784A1_0468
2.1.10|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O-C-c1:c:c:c:c:c:1.[C:2]-[N&H2&+0&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]1[C:10]([N:11]([C@H:12]1[CH3:13])[P:14](=[O:15])([OH:16])[O:17][CH2:18][C:19](=[O:20])OCc1ccccc1)=[O:21].[NH2:22][CH2:23][c:24]1[cH:25][c:26]([c:27]([cH:28][nH:29]1)[O:30][CH2:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)=[O:38].[K:39]>CN(C)C=O>[CH3:13][C@H:12]1[C@@H:9]([C:10]([N:11]1[P:14](=[O:15])([OH:16])[O:17][CH2:18][C:19](=[O:20])[NH:22][CH2:23][c:24]1[cH:25][c:26]([c:27]([cH:28][nH:29]1)[O:30][CH2:31][c:32]1[cH:37][cH:36][cH:35][cH:34][cH:33]1)=[O:38])=[O:21])[NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4].[K:39]|US20070208001A1_0479
1.6.2|[C:6]-[C&H2&+0&D2:5]-Br.[c:4]:[n&H0&+0&D2:3]:[n&H1&+0&D2:2]:[n:1]>>[C:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:3](:[c:4]):[n&H0&+0&D2:2]:[n:1]|[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5]Br.[cH:6]1[cH:7][n:8][nH:9][n:10]1>CCCC[N+](CCCC)(CCCC)CCCC.CC(C)=O.O[Na].O.[I-]>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][n:8]1[cH:7][cH:6][n:10][n:9]1|US08067407B2_0228
1.6.4|[c:6]-[C&H2&+0&D2:5]-Cl.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[c:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9]Cl.[CH3:10][CH2:11][O:12][C:13](=[O:14])[CH2:15][c:16]1[n:17][n:18][n:19][nH:20]1>CN(C)C=O.O=C(O[K])O[K]>[CH3:10][CH2:11][O:12][C:13](=[O:14])[CH2:15][c:16]1[n:17][n:18][n:19]([n:20]1)[CH2:9][c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[O:2][CH3:1]|US09067943B2_0473
1.9.20|[O&H0&D1:6]=[P&H0&+0&D4:5](-[O:4])(-[S:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[O&H0&D1:6]=[P&H0&+0&D4:5](-[O&H0&+0&D2:2]-[c:1])(-[O:4])-[S:3]|[CH3:1][O:2][P:3](=[O:4])(Cl)[S:5][CH2:6][CH3:7].[O:8]=[C:9]1[CH2:10][CH2:11][c:12]2[c:13]([cH:14][cH:15][c:16]([c:17]12)[OH:18])[Br:19]>Cc1ccccc1.CCN(CC)CC>[CH3:7][CH2:6][S:5][P:3](=[O:4])([O:2][CH3:1])[O:18][c:16]1[cH:15][cH:14][c:13]([c:12]2[CH2:11][CH2:10][C:9]([c:17]12)=[O:8])[Br:19]|US04452792A
1.7.17|[C:6]-[O&H1&+0&D1:5].[C:4]-[C&H1&+0&D3:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C:6]-[O&H0&+0&D2:5]-[C&H1&+0&D3:3](-[C:4])-[C:2]-[O&H1&+0&D1:1]|[CH3:1][C:2](=[O:3])[OH:4].[CH3:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[C:28](=[O:29])[O:30][CH2:31][CH:32]1[CH2:33][O:34]1>O>[CH3:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[C:28](=[O:29])[O:30][CH2:31][CH:32]([CH2:33][OH:34])[O:4][C:2]([CH3:1])=[O:3]|US09481682B2_0823
9.7.52|[N&H3&+0&D0:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[N&H2&+0&D1:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[NH3:1].[O:2]=[C:3]([OH:4])[c:5]1[cH:6][c:7]([c:8]([c:9]([cH:10]1)[S:11](=[O:12])(=[O:13])Cl)[O:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[S:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>>[NH2:1][S:11](=[O:12])(=[O:13])[c:9]1[cH:10][c:5]([cH:6][c:7]([c:8]1[O:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[S:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:3](=[O:2])[OH:4]|EP3445757B1_0677
3.11.34|[C:6]-[C&H2&+0&D2:5]-[S&H0&+0&D2:4]-[c:3]:[c:2]-[C&H1&+0&D2:1]=O>>[C:6]-[c&H0&+0&D3:5]1:[c&H1&+0&D2:1]:[c:2]:[c:3]:[s&H0&+0&D2:4]:1|[CH3:1][O:2][C:3](=[O:4])[CH2:5][S:6][c:7]1[cH:8][cH:9][s:10][c:11]1[CH:12]=O>CC([O-])=O.C1CC[NH2+]CC1>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:12][c:11]2[s:10][cH:9][cH:8][c:7]2[s:6]1|EP3233087B1_0419
2.3.11|[C:6]-[N&H1&+0&D2:5]-[C:4].[N:3]=[C&H0&+0&D3:2](-[O:1])-O-c1:c:c:c:c:c:1>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[N:3])-[O:1]|[N:1]#[C:2][N:3]=[C:4](Oc1ccccc1)[O:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1.[CH2:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1>ClCCl>[N:1]#[C:2][N:3]=[C:4]([O:5][c:6]1[cH:11][cH:10][cH:9][cH:8][cH:7]1)[N:15]1[CH2:16][CH2:17][CH2:12][CH2:13][CH2:14]1|US20080096861A1_0732
1.6.2|[C:6]-[C&H2&+0&D2:5]-Br.[n:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[C:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[n:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6]Br.[CH3:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:12]([OH:13])[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][c:26]([cH:27]1)-[c:28]1[n:29][n:30][nH:31][n:32]1>CCO.[Na]>[CH3:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:12]([OH:13])[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][c:26]([cH:27]1)-[c:28]1[n:32][n:31][n:30]([n:29]1)[CH2:6][C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20200231555A1_0890
4.1.13|[C&H3&+0&D1:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[N&H0&+0&D2:1](=O)-O-C-C-C-C>>[c&H1&+0&D2:5]1:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c:3]:[c:4]:1|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[C:9]#[N:10])[CH3:11])[NH2:12].CCCCO[N:13]=O>C1COCCOCCOCCOCCOCCO1.CC(=O)OC(C)=O.CCOC(C)=O.CC([O-])=O.ClC(Cl)Cl.CCO.O[K].[K+]>[CH3:1][O:2][c:3]1[cH:4][c:5]2[nH:12][n:13][cH:11][c:6]2[cH:7][c:8]1[C:9]#[N:10]|US20190382376A1_1253
1.6.2|[C:6]-[C&H2&+0&D2:5]-Br.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[c:1]>>[C:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1][CH2:2][CH2:3][CH2:4][n:5]1[c:6]([n:7]([c:8]([c:9]2[c:10]([n:11][nH:12][c:13]21)[NH2:14])=[O:15])[CH2:16][CH2:17][CH3:18])=[O:19].[Cl:20][CH2:21][CH2:22]Br>CN(C)C=O.O=C(O[K])O[K]>[CH3:1][CH2:2][CH2:3][CH2:4][n:5]1[c:13]2[n:12][n:11]([c:10]([c:9]2[c:8]([n:7]([c:6]1=[O:19])[CH2:16][CH2:17][CH3:18])=[O:15])[NH2:14])[CH2:22][CH2:21][Cl:20]|EP3083586B1_0191
2.1.17|[N&H2&+0&D1:5]-[S:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-c1:c:c:c:c:c:1>>[N&H1&+0&D2:5](-[S:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][c:2]1[cH:3][c:4]([n:5][c:6]([n:7]1)[NH:8][C:9](=[O:10])Oc1ccccc1)[O:11][CH:12]([F:13])[F:14].[CH3:15][CH2:16][O:17][CH2:18][CH2:19][O:20][c:21]1[cH:22][cH:23][cH:24][cH:25][c:26]1[S:27]([NH2:28])(=[O:29])=[O:30]>O.Cl.CCOC(C)=O.CC#N.C1=NCCCN2CCCCC12>[CH3:1][c:2]1[cH:3][c:4]([n:5][c:6]([n:7]1)[NH:8][C:9](=[O:10])[NH:28][S:27](=[O:29])(=[O:30])[c:26]1[cH:25][cH:24][cH:23][cH:22][c:21]1[O:20][CH2:19][CH2:18][O:17][CH2:16][CH3:15])[O:11][CH:12]([F:13])[F:14]|US20200299284A1_0384
1.2.14|[c:6]:[n&H1&+0&D2:5]:[n:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[c:6]:[n&H0&+0&D3:5](:[n:4])-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5]1([CH2:6][O:7]1)[CH2:8][O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16].[cH:17]1[n:18][cH:19][nH:20][n:21]1>CCO>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5]([OH:7])([CH2:8][O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16])[CH2:6][n:20]1[cH:19][n:18][cH:17][n:21]1|US20120108422A1_0526
1.7.17|[C:6]-[O&H1&+0&D1:5].[c:4]-[C&H1&+0&D3:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C:6]-[O&H0&+0&D2:5]-[C&H1&+0&D3:3](-[c:4])-[C:2]-[O&H1&+0&D1:1]|[O:1]=[C:2]1[O:3][C@@H:4]([C:5](=[C:6]1[OH:7])[OH:8])[C@@H:9]([OH:10])[CH2:11][OH:12].[cH:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[CH:19]1[CH2:20][O:21]1>OC(C(F)(F)F)C(F)(F)F.CC#N>[O:1]=[C:2]1[O:3][C@@H:4]([C:5](=[C:6]1[OH:7])[O:8][CH:19]([CH2:20][OH:21])[c:16]1[cH:17][cH:18][cH:13][cH:14][cH:15]1)[C@@H:9]([OH:10])[CH2:11][OH:12]|US20200165265A1_0282
2.1.2|[C:6]-[N&H1&+0&D2:5]-[C:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[O&-]>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][CH2:8][CH3:9].[O-][C:10](=[O:11])[NH:12][c:13]1[cH:14][cH:15][cH:16][c:17]([cH:18]1)[Br:19]>CCCCCC.C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:6][CH2:7][CH2:8][CH3:9])[C:10](=[O:11])[NH:12][c:13]1[cH:14][cH:15][cH:16][c:17]([cH:18]1)[Br:19]|US20190161479A1_0818
4.1.45|[N&H2&+0&D1:5]-[c:4]:[c:3]-[N&H0&+&D3:2](-[O&-])=O.[C&H1&+0&D2:1](=O)-O>>[n&H1&+0&D2:5]1:[c&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c:3]:[c:4]:1|[CH3:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[C:8](=[O:9])[CH:10]([CH2:11][c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[N+:18]([O-])=O)[NH2:19])[NH:20][S:21](=[O:22])(=[O:23])[c:24]1[cH:25][c:26]([c:27]([c:28]([cH:29]1)[Cl:30])[NH2:31])[Cl:32].O=[CH:33]O>[Pd]>[CH3:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[C:8](=[O:9])[CH:10]([CH2:11][c:12]1[cH:13][cH:14][c:15]2[nH:19][cH:33][n:18][c:16]2[cH:17]1)[NH:20][S:21](=[O:22])(=[O:23])[c:24]1[cH:29][c:28]([c:27]([c:26]([cH:25]1)[Cl:32])[NH2:31])[Cl:30]|EP3703134A1_0089
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]1-[C:2]-[N&H1&+0&D2:1]-1>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][C:2](=[O:3])[NH:4][CH2:5][C:6](=[O:7])O.[N:8]#[C:9][CH:10]1[CH2:11][NH:12]1>C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1>[CH3:1][C:2](=[O:3])[NH:4][CH2:5][C:6](=[O:7])[N:12]1[CH2:11][CH:10]1[C:9]#[N:8]|US20100152230A1_0366
2.1.3|[N&H2&+0&D1:5]-[N&H2&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|O.[CH3:1][N:2]1[CH2:3][c:4]2[c:5]([n:6][cH:7][n:8]2-[c:9]2[cH:10][cH:11][c:12]([cH:13][c:14]2[C:15]1=[O:16])[F:17])[C:18]([O-])=[O:19].[NH2:20][NH2:21]>CCO>[CH3:1][N:2]1[CH2:3][c:4]2[c:5]([n:6][cH:7][n:8]2-[c:9]2[cH:10][cH:11][c:12]([cH:13][c:14]2[C:15]1=[O:16])[F:17])[C:18](=[O:19])[NH:20][NH2:21]|US09694016B2_0418
2.1.2|[N&H2&+0&D1:5]-[O&H1&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[N&H1&+0&D2:5](-[O&H1&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH2:1][OH:2].[O-][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH2:12][CH2:13][NH:14][C:15](=[O:16])[c:17]1[o:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[c:25]1[CH2:26][O:27][CH2:28][C:29]([F:30])([F:31])[F:32]>[Na+].Cl.CO.[OH-]>[O:4]=[C:3]([NH:1][OH:2])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH2:12][CH2:13][NH:14][C:15](=[O:16])[c:17]1[o:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[c:25]1[CH2:26][O:27][CH2:28][C:29]([F:30])([F:31])[F:32]|EP3138840B1_0141
8.8.18|[C:6]-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[N&H1&+0&D2:3]-[c:2]:[c:1]-1>>[C:6]-[c&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[n&H1&+0&D2:3]:[c:2]:[c:1]:1|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH:19]1[CH2:20][NH:21][c:22]2[cH:23][cH:24][c:25]([cH:26][c:27]21)[C:28](=[O:29])[OH:30]>Cc1cc(cc(c1)C)C.[Pd]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][c:19]1[cH:20][nH:21][c:22]2[cH:23][cH:24][c:25]([cH:26][c:27]12)[C:28](=[O:29])[OH:30]|US05919783A
1.2.18|[C:6]-[N&H2&+0&D1:5].[C:4]-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:2](-[C:1])=[C&H1&+0&D2:3]-[C:4]|[CH3:1][CH2:2][C:3]([CH3:4])([CH3:5])[NH:6][C:7]([NH2:8])=[O:9].[O:10]=[C:11]1[CH2:12][C:13]([CH2:14][O:15]1)=O>c1ccccc1.O>[CH3:1][CH2:2][C:3]([CH3:4])([CH3:5])[NH:6][C:7](=[O:9])[NH:8][C:13]1=[CH:12][C:11]([O:15][CH2:14]1)=[O:10]|US10246436B2_0678
1.2.18|[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C:6]-[C&H1&+0&D2:5]=[C&H0&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][C:2]1([CH2:3][C:4]([CH2:5][C:6]([CH2:7]1)=[O:8])=O)[CH3:9].[NH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17]>>[CH3:1][C:2]1([CH2:7][C:6]([CH:5]=[C:4]([CH2:3]1)[NH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17])=[O:8])[CH3:9]|US08907089B2_0606
10.4.3|[O&H2&+0&D0:6].[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[O&H1&+0&D1:6]-[C&H1&+0&D3:4](-[C:5])-[C&H1&+0&D3:3](-[C:2])-[c:1]|[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[C:8]1=[CH:9][CH2:10][N:11]([CH2:12][CH2:13]1)[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[OH2:21]>CC[O+](CC)[B-](F)(F)F.COCCOC.OB(O)O.OO.O[K].[Na+].[BH4-]>[OH:21][CH:9]1[CH2:10][N:11]([CH2:12][CH2:13][CH:8]1[c:6]1[cH:7][c:2]([cH:3][cH:4][cH:5]1)[Br:1])[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20130203815A1_0160
1.2.16|[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C:4])-[C:3].[C:2]-[N&H2&+0&D1:1]>>[C&H2&+0&D2:6](-[N&H1&+0&D2:1]-[C:2])-[C&H1&+0&D3:5](-[C:4])-[C:3]|[CH2:1]=[C:2]([CH2:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[C:11](=[O:12])[O:13][CH2:14][CH3:15].[CH3:16][CH:17]([CH3:18])[NH2:19]>CCO>[CH3:15][CH2:14][O:13][C:11](=[O:12])[CH:2]([CH2:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[CH2:1][NH:19][CH:17]([CH3:16])[CH3:18]|US20200392150A1_0282
1.8.17|[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C:4])-[C:3].[S&H1&+0&D1:2]-[c:1]>>[C&H2&+0&D2:6](-[S&H0&+0&D2:2]-[c:1])-[C&H1&+0&D3:5](-[C:4])-[C:3]|[CH2:1]=[C:2]([CH2:3][C:4](=[O:5])[OH:6])[C:7](=[O:8])[OH:9].[SH:10][c:11]1[n:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[s:19]1>O.CCOCC.CCOC(C)=O.Cl[Al](Cl)Cl>[O:5]=[C:4]([OH:6])[CH2:3][CH:2]([CH2:1][S:10][c:11]1[n:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[s:19]1)[C:7](=[O:8])[OH:9]|US08629169B2_0082
1.2.18|[C:6]-[N&H2&+0&D1:5].[C:4]-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:2](-[c:1])=[C&H1&+0&D2:3]-[C:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=O)[c:8]1[cH:9][n:10][cH:11][cH:12][cH:13]1.[CH3:14][CH2:15][O:16][C:17](=[O:18])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH2:24]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]=[C:7]([NH:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][C:17](=[O:18])[O:16][CH2:15][CH3:14])[c:8]1[cH:13][cH:12][cH:11][n:10][cH:9]1|US09771332B2_0155
9.7.20|[O:5]-[B&H0&+0&D3:4](-[O:3])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:2]-[C&H2&+0&D2:1]-Br>>[O:5]-[B&H0&+0&D3:4](-[O:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])B1OC(C(O1)(C)C)(C)C)[CH3:9].[CH3:10][O:11][C:12](=[O:13])[CH2:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[CH2:21]Br>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCOC(C)=O.C1COCCO1.[O-]C([O-])=O.[K+].[K+]>[CH3:10][O:11][C:12](=[O:13])[CH2:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[CH2:21][B:4]1[O:3][C:2]([C:6]([O:5]1)([CH3:7])[CH3:8])([CH3:1])[CH3:9]|US20200354382A1_0452
2.1.2|[C:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[O&-]>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[C@@H:8]1[CH2:9][CH2:10][CH2:11][NH:12]1.[CH3:13][CH2:14][O:15][C:16](=[O:17])[CH:18]([CH3:19])[C:20]([O-])=[O:21]>C(=NC1CCCCC1)=NC1CCCCC1.ClCCl.O>[CH3:13][CH2:14][O:15][C:16](=[O:17])[CH:18]([CH3:19])[C:20](=[O:21])[N:12]1[CH2:11][CH2:10][CH2:9][C@H:8]1[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|EP3134408B1_0232
7.6.1|[C:6]-[c&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[c:3]:[c:2]:[o&H0&+0&D2:1]:1>>[C:6]-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[c:3]:[c:2]-[O&H0&+0&D2:1]-1|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[o:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>[Na].[Na].[Hg]>[O:1]=[C:2]([OH:3])[CH:4]1[CH2:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[O:12]1)-[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|EP2651931B1_0320
3.11.34|[C:6]-[C&H2&+0&D2:5]-[C:4]-[O&H0&+0&D2:3]-C.[c:2]-[C&H1&+0&D2:1]=O>>[C:6]-[C&H0&+0&D3:5](=[C&H1&+0&D2:1]-[c:2])-[C:4]-[O&H1&+0&D1:3]|[CH3:1][N:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH:10]=O.C[O:11][C:12](=[O:13])[CH2:14][C:15]#[N:16]>Cl.CCO.O[Na]>[CH3:1][N:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH:10]=[C:14]([C:15]#[N:16])[C:12](=[O:13])[OH:11]|US04022814A
7.6.1|[C:6]-[n&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1>>[C:6]-[N&H0&+0&D3:5]1-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1|[N:1]#[C:2][CH2:3][n:4]1[cH:5][cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21>O=C(O)C(F)(F)F.c1c[nH]c2ccccc12.C1CCOC1.B.B>[N:1]#[C:2][CH2:3][N:4]1[CH2:5][CH2:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21|US06207693B1
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[O&-].[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[O-][C:1](=[O:2])[CH2:3][O:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][c:10]([cH:11][c:12]([cH:13]1)[Cl:14])[Cl:15]>[O-]C(=O)N(C(=O)Nc1cc(cc(c1)Cl)Cl)c1cc(cc(c1)Cl)Cl>[O:2]=[C:1]1[CH2:3][O:4][C:5]([N:7]1[c:8]1[cH:13][c:12]([cH:11][c:10]([cH:9]1)[Cl:15])[Cl:14])=[O:6]|EP2658844B1_1249
7.6.1|[C:6]-[c&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[o&H0&+0&D2:3]:[c:2]:[c:1]:1>>[C:6]-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[O&H0&+0&D2:3]-[c:2]:[c:1]-1|[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[CH2:7][c:8]1[cH:9][o:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]12>CC[SiH](CC)CC.O=C(O)C(F)(F)F>[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[CH2:7][CH:8]1[CH2:9][O:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21|US06407096B1
3.11.86|[C:7]-[C&H1&+0&D3:6](-[C:5])-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8]([c:9]2[c:10]([cH:11][c:12]([cH:13][c:14]2F)[I:15])[c:16]1=[O:17])[N:18]([CH3:19])[CH2:20][CH:21]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35]>O=C(O[Cs])O[Cs].CC(=O)O.CS(C)=O.O>[CH3:33][C:32]([CH3:34])([CH3:35])[O:31][C:29](=[O:30])[C:21]1([CH2:20][N:18]([n:8]2[cH:7][c:6]([c:16]([c:10]3[cH:11][c:12]([cH:13][c:14]1[c:9]32)[I:15])=[O:17])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[CH3:19])[C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28]|US08093402B2_0298
7.6.1|[C:6]-[c&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1>>[C:6]-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[c:3]:[c:2]-[N&H1&+0&D2:1]-1|[OH:1][CH2:2][CH2:3][c:4]1[cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[nH:12]1>O.[Na+].CC(=O)O.N#C[BH3-]>[OH:1][CH2:2][CH2:3][CH:4]1[CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[NH:12]1|US09758510B2_0919
3.1.1|[C:5]=[C&H1&+0&D2:4]-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][N:2]1[CH2:3][CH2:4][CH2:5][n:6]2[c:7]([CH2:8]1)[c:9]([n:10][c:11]2Br)[C:12](=[O:13])[NH:14][C@H:15]([C:16](=[O:17])[NH:18][CH3:19])[C:20]([CH3:21])([CH3:22])[CH3:23].CC1(OB(OC1(C)C)/[CH:24]=[CH:25]/[CH2:26][CH2:27][O:28][Si:29]([CH3:30])([CH3:31])[C:32]([CH3:33])([CH3:34])[CH3:35])C>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCOC(C)=O.C1COCCO1.[O-]C([O-])=O.O.[K+].[K+]>[CH3:19][NH:18][C:16](=[O:17])[C@@H:15]([NH:14][C:12](=[O:13])[c:9]1[n:10][c:11]([n:6]2[c:7]1[CH2:8][N:2]([CH2:3][CH2:4][CH2:5]2)[CH3:1])/[CH:24]=[CH:25]/[CH2:26][CH2:27][O:28][Si:29]([CH3:30])([CH3:31])[C:32]([CH3:33])([CH3:34])[CH3:35])[C:20]([CH3:21])([CH3:22])[CH3:23]|US20200190045A1_0790
1.2.1|[N&H2&+0&D1:6]-[C:5]-[C:4]-[O&H0&+0&D2:3]-C.[c:2]-[C&H1&+0&D2:1]=O>>[N&H1&+0&D2:6](-[C&H2&+0&D2:1]-[c:2])-[C:5]-[C:4]-[O&H1&+0&D1:3]|C[O:1][C:2](=[O:3])[C@@H:4]([NH2:5])[CH2:6][OH:7].O=[CH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.Cl>CCN(CC)CC.CO.O[Na].O.[Na+].Cl.[BH4-]>[O:3]=[C:2]([OH:1])[C@H:4]([CH2:6][OH:7])[NH:5][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|EP2740729B1_0074
1.8.17|[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C:4])-[C:3].[C:2]-[S&H1&+0&D1:1]>>[C&H2&+0&D2:6](-[S&H0&+0&D2:1]-[C:2])-[C&H1&+0&D3:5](-[C:4])-[C:3]|[CH2:1]=[C:2]([CH2:3][CH2:4][CH2:5][NH:6][C:7](=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[O:17][CH3:18])[C:19](=[O:20])[OH:21].[CH3:22][C:23](=[O:24])[SH:25]>>[CH3:18][O:17][c:14]1[cH:13][cH:12][c:11]([cH:16][cH:15]1)[CH2:10][O:9][C:7](=[O:8])[NH:6][CH2:5][CH2:4][CH2:3][CH:2]([CH2:1][S:25][C:23]([CH3:22])=[O:24])[C:19](=[O:20])[OH:21]|EP0402646A1_0415
9.7.20|[C:5]=[C&H1&+0&D2:4]-Br.[O:3]-[B&H0&+0&D3:2](-[O:1])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1>>[C:5]=[C&H1&+0&D2:4]-[B&H0&+0&D3:2](-[O:3])-[O:1]|CC1(OB(OC1(C)C)[B:1]1[O:2][C:3]([C:4]([O:5]1)([CH3:6])[CH3:7])([CH3:8])[CH3:9])C.[F:10][c:11]1[cH:12][cH:13][c:14]2/[C:15]([c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[CH2:22][O:23][c:24]2[cH:25]1)=[CH:26]/Br>[CH]1[CH][CH][C]([CH]1)[PH+](c1ccccc1)c1ccccc1.[CH]1[CH][CH][C]([CH]1)[PH+](c1ccccc1)c1ccccc1.C1COCCO1.CC([O-])=O.ClCCl.Cl[Pd]Cl.[K+].[Fe]>[CH3:8][C:3]1([O:2][B:1]([O:5][C:4]1([CH3:6])[CH3:7])/[CH:26]=[C:15]1\[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[CH2:22][O:23][c:24]2[c:14]1[cH:13][cH:12][c:11]([cH:25]2)[F:10])[CH3:9]|EP3389658B1_0128
7.6.1|[C:6]-[c&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[n&H1&+0&D2:3]:[c:2]:[c:1]:1>>[C:6]-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[N&H1&+0&D2:3]-[c:2]:[c:1]-1|[CH3:1][N:2]1[CH2:3][CH:4]([CH2:5][C@@H:6]2[c:7]3[cH:8][cH:9][cH:10][c:11]4[nH:12][cH:13][c:14]([CH2:15][C@H:16]21)[c:17]34)[CH2:18][C:19]#[N:20]>[NH4+].[Na+].O=C(O)C(F)(F)F.[BH4-].[OH-]>[CH3:1][N:2]1[CH2:3][CH:4]([CH2:5][C@@H:6]2[c:7]3[cH:8][cH:9][cH:10][c:11]4[NH:12][CH2:13][CH:14]([CH2:15][C@H:16]21)[c:17]34)[CH2:18][C:19]#[N:20]|US04798834A
2.1.2|[C:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=[O:10])[c:11]1[cH:12][c:13]([cH:14][cH:15][c:16]1-[n:17]1[n:18][c:19]([n:20][c:21]1[CH2:22][Cl:23])[C:24]([O-])=[O:25])[Cl:26].CC[NH+](CC)CC.[CH2:27]1[CH2:28][NH:29][CH2:30][CH2:31][O:32]1>CCOC(=O)Cl.C1CCOC1.O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=[O:10])[c:11]1[cH:12][c:13]([cH:14][cH:15][c:16]1-[n:17]1[n:18][c:19]([n:20][c:21]1[CH2:22][Cl:23])[C:24](=[O:25])[N:29]1[CH2:30][CH2:31][O:32][CH2:27][CH2:28]1)[Cl:26]|US10494376B2_0843
3.1.2|[c:5]-[C&H2&+0&D2:4]-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|CC1(OB(OC1(C)C)[CH2:1][c:2]1[cH:3][cH:4][c:5]2[O:6][CH2:7][O:8][c:9]2[cH:10]1)C.[CH3:11][CH2:12][O:13][C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][n:20][c:21]1Cl>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CC([O-])=O.CC([O-])=O.[Pd+2]>[CH3:11][CH2:12][O:13][C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][n:20][c:21]1[CH2:1][c:2]1[cH:3][cH:4][c:5]2[O:6][CH2:7][O:8][c:9]2[cH:10]1|US20200354384A1_1593
8.8.18|[C:6]-[N&H0&+0&D3:5]1-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1>>[C:6]-[n&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][c:9]2[c:10]([cH:11]1)[CH2:12][CH2:13][N:14]2[C:15]([CH3:16])=[O:17]>[Pd]>[CH3:16][C:15](=[O:17])[n:14]1[cH:13][cH:12][c:10]2[cH:11][c:6]([cH:7][cH:8][c:9]21)[CH2:5][C:3](=[O:4])[O:2][CH3:1]|EP0976732B1_1157
9.7.217|[C&H3&+0&D1:5]-[S&H0&+0&D3:4](-[C&H3&D1:3])=O.[C:2]-[O&H1&+0&D1:1]>>[C&H2&+0&D2:5](-[O&H0&+0&D2:1]-[C:2])-[S&H0&+0&D2:4]-[C&H3&D1:3]|[CH3:1][CH:2]([CH2:3][O:4][Si:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:22][CH2:23][CH2:24][C:25]([CH3:26])([OH:27])[C:28](=[O:29])[CH2:30][CH2:31][C:32]1([O:33][CH2:34][CH2:35][O:36]1)[CH2:37][O:38][S:39](=[O:40])(=[O:41])[c:42]1[cH:43][cH:44][c:45]([cH:46][cH:47]1)[CH3:48].[CH3:49][S:50]([CH3:51])=O>CC(=O)OC(C)=O>[CH3:48][c:45]1[cH:44][cH:43][c:42]([cH:47][cH:46]1)[S:39](=[O:40])(=[O:41])[O:38][CH2:37][C:32]1([O:33][CH2:34][CH2:35][O:36]1)[CH2:31][CH2:30][C:28](=[O:29])[C:25]([CH3:26])([CH2:24][CH2:23][CH2:22][CH:2]([CH3:1])[CH2:3][O:4][Si:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[C:18]([CH3:19])([CH3:20])[CH3:21])[O:27][CH2:51][S:50][CH3:49]|US20180327828A1_0226
3.11.86|[C:7]-[C&H1&+0&D3:6](-[C:5])-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH2:7][CH2:8][C:9]#[N:10])[C:11](=[O:12])[O:13][CH2:14][CH3:15].[CH3:16][c:17]1[cH:18][c:19]([cH:20][n:21][c:22]1Cl)[N+:23]([O-:24])=[O:25]>C1CCOC1.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH2:7][CH2:8][C:9]#[N:10])([C:11](=[O:12])[O:13][CH2:14][CH3:15])[c:22]1[n:21][cH:20][c:19]([cH:18][c:17]1[CH3:16])[N+:23]([O-:24])=[O:25]|US20110124634A1_0328
2.3.3|[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[S&H0&-&D1:3].[N&H2&+0&D1:2]-[c:1]>>[N&H2&+0&D1:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[S&H0&+0&D1:3]|[NH4+].Cl.[CH3:1][c:2]1[nH:3][n:4][c:5]([c:6]1[NH2:7])[CH3:8].[N:9]#[C:10][S-:11]>O>[CH3:1][c:2]1[nH:3][n:4][c:5]([c:6]1[NH:7][C:10]([NH2:9])=[S:11])[CH3:8]|EP3344997B1_0158
4.2.20|[O&H1&+0&D1:6]-[C:5]-[C:4]-[O&H1&+0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[O&H0&+0&D2:6]1-[C&H1&+0&D3:1](-[O&H0&+0&D2:3]-[C:4]-[C:5]-1)-[c:2]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[C:9]([OH:10])([CH2:11][OH:12])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.O=[CH:19][c:20]1[cH:21][cH:22][cH:23][o:24]1>>[O:1]=[C:2]([c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1)[C:9]1([CH2:11][O:12][CH:19]([O:10]1)[c:20]1[cH:21][cH:22][cH:23][o:24]1)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|EP3210626A1_0042
4.1.42|[N&H2&+0&D1:5]-[c:4]:[c:3]-[C&H0&+0&D2:2]#[C&H0&+0&D2:1]-[#14](-C)(-C)-C>>[n&H1&+0&D2:5]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c:3]:[c:4]:1|C[Si](C)(C)[C:1]#[C:2][c:3]1[cH:4][c:5]([cH:6][n:7][c:8]1[NH2:9])[Cl:10]>CN1CCCC1=O.CC(C)(C)O[K]>[Cl:10][c:5]1[cH:6][n:7][c:8]2[nH:9][cH:1][cH:2][c:3]2[cH:4]1|US08822469B2_0327
1.6.4|[C:7]-[N&H1&+0&D2:6]-[C:5].[c:4]-[C&H0&+0&D4:3](-[c:2])(-[c:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D4:3](-[c:4])(-[c:2])-[c:1]|Cl[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[OH:20][CH2:21][CH2:22][N:23]1[CH2:24][CH2:25][NH:26][CH2:27][CH2:28]1>CN(C)C.ClCCl>[OH:20][CH2:21][CH2:22][N:23]1[CH2:24][CH2:25][N:26]([CH2:27][CH2:28]1)[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|EP3064205A1_0096
1.8.17|[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C:4])-[N:3].[C:2]-[S&H1&+0&D1:1]>>[C&H2&+0&D2:6](-[S&H0&+0&D2:1]-[C:2])-[C@&H1&+0&D3:5](-[C:4])-[N:3]|[CH2:1]=[C:2]1[C:3]([N:4]([C@H:5]([C:6]([NH:7][CH:8]([C:9]([N:10]([CH:11]([C:12]([NH:13][CH:14]([C:15]([NH:16][CH:17]([C:18]([N:19]([CH:20]([C:21]([N:22]([CH:23]([C:24]([N:25]([CH:26]([C:27]([N:28]([CH:29]([C:30]([NH:31][CH:32]([C:33]([N:34]1[CH3:35])=[O:36])[CH2:37][CH3:38])=[O:39])[C@H:40]([OH:41])[C@H:42]([CH3:43])[CH2:44][CH2:45][CH2:46][CH3:47])[CH3:48])=[O:49])[CH:50]([CH3:51])[CH3:52])[CH3:53])=[O:54])[CH2:55][CH:56]([CH3:57])[CH3:58])[CH3:59])=[O:60])[CH2:61][CH:62]([CH3:63])[CH3:64])[CH3:65])=[O:66])[CH3:67])=[O:68])[CH3:69])=[O:70])[CH2:71][CH:72]([CH3:73])[CH3:74])[CH3:75])=[O:76])[CH:77]([CH3:78])[CH3:79])=[O:80])[CH2:81][CH:82]([CH3:83])[CH3:84])[CH3:85])=[O:86].[CH3:87][CH2:88][N:89]([CH2:90][CH3:91])[CH2:92][CH2:93][SH:94]>Cl.CC#N.O=C(O[K])O[K].O=C(O[Cs])O[Cs]>[CH3:83][CH:82]([CH3:84])[CH2:81][C@H:5]1[C:6]([NH:7][CH:8]([C:9]([N:10]([CH:11]([C:12]([NH:13][CH:14]([C:15]([NH:16][CH:17]([C:18]([N:19]([CH:20]([C:21]([N:22]([CH:23]([C:24]([N:25]([CH:26]([C:27]([N:28]([CH:29]([C:30]([NH:31][CH:32]([C:33]([N:34]([C@@H:2]([C:3]([N:4]1[CH3:85])=[O:86])[CH2:1][S:94][CH2:93][CH2:92][N:89]([CH2:90][CH3:91])[CH2:88][CH3:87])[CH3:35])=[O:36])[CH2:37][CH3:38])=[O:39])[C@H:40]([OH:41])[C@H:42]([CH3:43])[CH2:44][CH2:45][CH2:46][CH3:47])[CH3:48])=[O:49])[CH:50]([CH3:51])[CH3:52])[CH3:53])=[O:54])[CH2:55][CH:56]([CH3:57])[CH3:58])[CH3:59])=[O:60])[CH2:61][CH:62]([CH3:63])[CH3:64])[CH3:65])=[O:66])[CH3:67])=[O:68])[CH3:69])=[O:70])[CH2:71][CH:72]([CH3:73])[CH3:74])[CH3:75])=[O:76])[CH:77]([CH3:78])[CH3:79])=[O:80]|
3.11.86|[C:7]-[C&H1&+0&D3:6](-[C:5])-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH2:7][CH3:8])[C:9](=[O:10])[O:11][CH2:12][CH3:13].[O-:14][N+:15](=[O:16])[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)Cl>CN(C)C=O.[H][H].[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH2:7][CH3:8])([C:9](=[O:10])[O:11][CH2:12][CH3:13])[c:20]1[cH:21][cH:22][c:17]([cH:18][cH:19]1)[N+:15]([O-:14])=[O:16]|US20180057505A1_0629
3.11.27|[C&H2&+0&D1:5]=[C&H0&+0&D3:4](-[C:3])-[C:2].[C&H3&+0&D1:1]-[S&+](-C)-C>>[C&H2&+0&D2:5]1-[C&H2&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C:3])-[C:2]|[I-].[CH2:1]=[C:2]([CH2:3][O:4][C@@H:5]1[CH2:6][CH2:7][CH2:8][C@@H:9]([CH2:10]1)[O:11][CH2:12][c:13]1[n:14][c:15]([o:16][c:17]1[CH3:18])-[c:19]1[cH:20][cH:21][cH:22][c:23]([cH:24]1)[CH3:25])[C:26](=[O:27])[O:28][CH2:29][CH3:30].C[S+](C)[CH3:31]>O.O.CS(C)=O.[NaH]>[CH3:25][c:23]1[cH:22][cH:21][cH:20][c:19]([cH:24]1)-[c:15]1[n:14][c:13]([c:17]([o:16]1)[CH3:18])[CH2:12][O:11][C@H:9]1[CH2:8][CH2:7][CH2:6][C@H:5]([CH2:10]1)[O:4][CH2:3][C:2]1([CH2:1][CH2:31]1)[C:26](=[O:27])[O:28][CH2:29][CH3:30]|EP3483143A1_1859
4.2.9|[C&H3&+0&D1:5]-[S&+](-C)-C.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H2&+0&D2:5]1-[O&H0&+0&D2:2]-[C&H0&+0&D4:3]-1(-[C:4])-[c:1]|[I-].[CH3:1][CH2:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][n:8][cH:9][cH:10]1.C[S+](C)[CH3:11]>O.CCCCCC.CCCC[Li].C1CCOC1>[CH3:1][CH2:2][C:3]1([CH2:11][O:4]1)[c:5]1[cH:6][cH:7][n:8][cH:9][cH:10]1|EP1535914A1_0084
3.11.86|[C:7]-[C&H1&+0&D3:6](-[C:5])-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]([CH:3]=[C:4]1[CH2:5][CH2:6][CH:7]([C:8]1=[O:9])[CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.Br[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>c1ccc(cc1)P(c1ccccc1)c1ccc2ccccc2c1-c1c2ccccc2ccc1P(c1ccccc1)c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.Cc1ccccc1.CCCC[O-].[Na+].[Pd].[Pd]>[CH3:14][CH2:13][CH2:12][CH2:11][CH2:10][C:7]1([CH2:6][CH2:5][C:4]([C:8]1=[O:9])=[CH:3][N:2]([CH3:1])[c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1|US20190077784A1_2200
4.2.9|[C&H3&+0&D1:5]-[S&+](-C)-C.[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C&H2&+0&D2:5]1-[O&H0&+0&D2:4]-[C&H0&+0&D4:3]-1(-[c:2])-[c:1]|[I-].C[S+](C)[CH3:1].[O:2]=[C:3]([c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[I:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]>CCOC(C)=O.CS(C)=O.[NaH]>[Cl:17][c:14]1[cH:13][cH:12][c:11]([cH:16][cH:15]1)[C:3]1([CH2:1][O:2]1)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[I:10]|US05817678A
3.10.2|[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-Br.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|Br[C:1]12[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:8]3)[CH2:9]1)[CH2:10]2.[cH:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>Cl[Fe](Cl)Cl>[cH:14]1[cH:13][cH:12][c:11]([cH:16][cH:15]1)[C:1]12[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:8]3)[CH2:9]1)[CH2:10]2|US20200181104A1_0578
4.3.11|[N&H2&+0&D1:6]-[C:5]-[C:4]-[S&H1&+0&D1:3].[c:2]-[C&H0&+0&D2:1]#N>>[N&H0&+0&D2:6]1=[C&H0&+0&D3:1](-[S&H0&+0&D2:3]-[C:4]-[C:5]-1)-[c:2]|N#[C:1][c:2]1[cH:3][cH:4][c:5]([cH:6][n:7]1)[C:8](=[O:9])[OH:10].[NH2:11][CH2:12][CH2:13][SH:14]>O.Cl.CCO.[Na]>[O:9]=[C:8]([OH:10])[c:5]1[cH:4][cH:3][c:2]([n:7][cH:6]1)[C:1]1=[N:11][CH2:12][CH2:13][S:14]1|US20140093960A1_0083
5.5.5|[S&H1&+0&D1:6]-[C:5]-[C:4]-[S&H1&+0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[S&H0&+0&D2:6]1-[C&H1&+0&D3:1](-[S&H0&+0&D2:3]-[C:4]-[C:5]-1)-[c:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH:16]=O.[SH:17][CH2:18][CH2:19][SH:20]>>[CH3:13][C:12]([CH3:14])([CH3:15])[c:9]1[cH:8][c:7]([cH:6][c:5]([c:10]1[OH:11])[C:2]([CH3:1])([CH3:3])[CH3:4])[CH:16]1[S:20][CH2:19][CH2:18][S:17]1|US05106408A
3.11.16|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[N:1]#[C:2][c:3]1[n:4][n:5]([cH:6][c:7]1I)-[c:8]1[c:9]([cH:10][c:11]([cH:12][c:13]1[Cl:14])[C:15]([F:16])([F:17])[F:18])[Cl:19].[O:20]=[C:21](Cl)[CH:22]1[CH2:23][CH2:24]1>CCCC[Li].C1CCOC1.[O-]C(=O)O.[Na+]>[N:1]#[C:2][c:3]1[n:4][n:5]([cH:6][c:7]1[C:21](=[O:20])[CH:22]1[CH2:23][CH2:24]1)-[c:8]1[c:9]([cH:10][c:11]([cH:12][c:13]1[Cl:14])[C:15]([F:16])([F:17])[F:18])[Cl:19]|EP3080092B1_0303
4.2.9|[C&H3&+0&D1:5]-[S&+](-C)-C.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H2&+0&D2:5]1-[O&H0&+0&D2:1]-[C&H0&+0&D4:3]-1(-[C:4])-[C:2]|[CH3:1][C:2]([CH3:3])([CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[Cl:12])[C:13](=[O:14])[CH2:15][n:16]1[cH:17][n:18][cH:19][n:20]1.C[S+](C)[CH3:21].[I-]>CC(C)(C)[O-].C1CCOC1.CS(C)=O.O.[K+]>[CH3:1][C:2]([CH3:3])([CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[Cl:12])[C:13]1([CH2:21][O:14]1)[CH2:15][n:16]1[cH:17][n:18][cH:19][n:20]1|US20030134896A1_0231
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O-[#3].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[O:14]=[C:15](O[Li])[CH:16]1[CH2:17][CH2:18][N:19]([CH2:20][CH2:21]1)[CH2:22][C@@H:23]([OH:24])[CH2:25][O:26][c:27]1[cH:28][cH:29][cH:30][c:31]2[n:32][cH:33][cH:34][cH:35][c:36]21>>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[C:15](=[O:14])[CH:16]1[CH2:17][CH2:18][N:19]([CH2:20][CH2:21]1)[CH2:22][C@@H:23]([OH:24])[CH2:25][O:26][c:27]1[cH:28][cH:29][cH:30][c:31]2[n:32][cH:33][cH:34][cH:35][c:36]21|
2.3.12|[C:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-n1:c:[n&+](-C):c:c:1>>[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|C[n+]1ccn(c1)[C:1](=[O:2])[N:3]1[CH2:4][C:5](=[CH:6][C@H:7]1[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][c:16]([cH:17][cH:18][c:19]1[F:20])[F:21].[CH3:22][C:23]([CH3:24])([CH3:25])[O:26][C:27](=[O:28])[N:29]1[CH2:30][CH2:31][CH:32]([CH2:33][CH2:34]1)[NH2:35]>CCN(CC)CC.ClCCl>[CH3:22][C:23]([CH3:24])([CH3:25])[O:26][C:27](=[O:28])[N:29]1[CH2:30][CH2:31][CH:32]([CH2:33][CH2:34]1)[NH:35][C:1](=[O:2])[N:3]1[CH2:4][C:5](=[CH:6][C@H:7]1[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][c:16]([cH:17][cH:18][c:19]1[F:20])[F:21]|US20200390760A1_0260
3.11.16|[C:6]=[C&H0&+0&D3:5](-[F&H0&D1:4])-F.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]=[C&H0&+0&D3:5](-[F&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)Br.[F:10]/[C:11]([Cl:12])=[C:13](\[F:14])F>[Mg]>[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:13](/[F:14])=[C:11](\[F:10])[Cl:12]|US20190330530A1_0465
1.6.4|[C:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[C:9]1([C:10]([NH:11][c:12]2[cH:13][cH:14][c:15]([cH:16][c:17]21)[Cl:18])=[O:19])Cl.[CH3:20][CH2:21][NH:22][C:23](=[O:24])[C@@H:25]1[CH2:26][CH:27]([CH2:28][NH:29]1)[F:30]>CCN(CC)CC.O=C(O[K])O[K].ClC(Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[C:9]1([C:10]([NH:11][c:12]2[cH:13][cH:14][c:15]([cH:16][c:17]21)[Cl:18])=[O:19])[N:29]1[CH2:28][CH:27]([CH2:26][C@H:25]1[C:23](=[O:24])[NH:22][CH2:21][CH3:20])[F:30]|EP2989096B1_0155
1.6.4|[c:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[c:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|Cl[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[CH3:20][O:21][C:22](=[O:23])[c:24]1[cH:25][c:26]([nH:27][n:28]1)[C:29](=[O:30])[O:31][CH3:32]>CN(C)C=O.O.[Na+].[H-].[H][H]>[CH3:20][O:21][C:22](=[O:23])[c:24]1[cH:25][c:26]([n:27]([n:28]1)[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)[C:29](=[O:30])[O:31][CH3:32]|US20200377487A1_0644
9.7.41|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#11].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=[O:10])Cl.[N:11]#[C:12][Na]>CCCC[N+](CCCC)(CCCC)CCCC.CCCCCC.ClCCl.O.[Br-]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=[O:10])[C:12]#[N:11]|US06037495A
4.2.17|[N&H2&+0&D1:5]-[c:4]:[c:3]-[O&H1&+0&D1:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:5]1:[c:4]:[c:3]:[o&H0&+0&D2:2]:[c&H1&+0&D2:1]:1|CO[CH:1](OC)OC.[NH2:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[OH:9])[C:10](=[O:11])[OH:12]>>[O:11]=[C:10]([OH:12])[c:5]1[cH:6][cH:7][c:8]2[o:9][cH:1][n:2][c:3]2[cH:4]1|US20040082625A1_0372
2.8.3|[N&H2&+0&D1:6]-[c:5].[O&H0&D1:4]=[P&H0&+0&D4:3](-[O:2])(-[O:1])-Cl>>[N&H1&+0&D2:6](-[c:5])-[P&H0&+0&D4:3](=[O&H0&D1:4])(-[O:2])-[O:1]|[NH2:1][c:2]1[n:3][cH:4][c:5]([s:6]1)[C:7]([OH:8])([C:9]([F:10])([F:11])[F:12])[C:13]([F:14])([F:15])[F:16].[CH3:17][CH2:18][O:19][P:20](=[O:21])(Cl)[O:22][CH2:23][CH3:24]>CN(C)c1ccncc1.CCN(CC)CC.ClCCl>[CH3:17][CH2:18][O:19][P:20](=[O:21])([NH:1][c:2]1[n:3][cH:4][c:5]([s:6]1)[C:7]([OH:8])([C:9]([F:10])([F:11])[F:12])[C:13]([F:14])([F:15])[F:16])[O:22][CH2:23][CH3:24]|US20130281708A1_0054
2.1.1|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[C:3]1-[C:2]-[N&H1&+0&D2:1]-1>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[N&H0&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[C:9](=[O:10])Cl)[F:11].[CH2:12]1[CH2:13][NH:14]1>O.[Na+].[O-]C(=O)O.O[Na].ClC(Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[C:9](=[O:10])[N:14]1[CH2:12][CH2:13]1)[F:11]|EP0263208A2_0049
1.6.4|[c:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[c:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[Cl:1][c:2]1[n:3][c:4]([n:5][c:6]([c:7]1[Cl:8])[Cl:9])[C:10](Cl)([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1.[cH:23]1[cH:24][nH:25][cH:26][n:27]1>CC#N>[Cl:8][c:7]1[c:6]([n:5][c:4]([n:3][c:2]1[Cl:1])[C:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[n:25]1[cH:24][cH:23][n:27][cH:26]1)[Cl:9]|EP2711368A1_0169
4.1.45|[N&H2&+0&D1:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:5]1:[c:4]:[c:3]:[n&H1&+0&D2:2]:[c&H1&+0&D2:1]:1|CO[CH:1](OC)OC.[NH2:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[NH2:9])[CH:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[n:17]1[cH:18][cH:19][n:20][cH:21]1>CC(=O)O>[cH:19]1[cH:18][n:17]([cH:21][n:20]1)[CH:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:6]1[cH:5][cH:4][c:3]2[nH:2][cH:1][n:9][c:8]2[cH:7]1|US20200392174A1_0262
4.1.128|[N&H2&+0&D1:6]-[C:5]-[C:4]-[N&H2&+0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[N&H0&+0&D2:6]1=[C&H0&+0&D3:1](-[N&H1&+0&D2:3]-[C:4]-[C:5]-1)-[c:2]|[NH2:1][CH2:2][CH2:3][NH2:4].O=[CH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1>O=C1CCC(N1Br)=O.O[Na].ClCCl>[cH:10]1[cH:9][cH:8][cH:7][c:6]([n:11]1)[C:5]1=[N:4][CH2:3][CH2:2][NH:1]1|US20050101595A1_0802
1.9.1|[C:6]-[C&H2&+0&D2:5]-I.[O&H0&-&D1:4]-[P&H0&+0&D3:3](-[O:2])-[O:1]>>[C:6]-[C&H2&+0&D2:5]-[P&H0&+0&D4:3](=[O&H0&+0&D1:4])(-[O:2])-[O:1]|[CH3:1][C:2]1([O:3][CH2:4][CH:5]([CH2:6][O:7]1)[CH2:8]I)[CH3:9].[CH3:10][O:11][P:12]([O-:13])[O:14][CH3:15]>CC(=O)N(C)C.O=C(O[Cs])O[Cs]>[CH3:10][O:11][P:12](=[O:13])([CH2:8][CH:5]1[CH2:6][O:7][C:2]([O:3][CH2:4]1)([CH3:1])[CH3:9])[O:14][CH3:15]|
4.1.122|[C&H3&+0&D1:6]-[c:5]:[c:4]-[N&H1&+0&D2:3]-[C&H0&+0&D3:2](-[C:1])=O>>[c&H1&+0&D2:6]1:[c:5]:[c:4]:[n&H1&+0&D2:3]:[c&H0&+0&D3:2]:1-[C:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16](=O)[NH:17][c:18]1[cH:19][c:20]([cH:21][cH:22][c:23]1[CH3:24])[C:25](=[O:26])[OH:27]>O.Cl.CC(C)(C)O[K]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][c:16]1[cH:24][c:23]2[cH:22][cH:21][c:20]([cH:19][c:18]2[nH:17]1)[C:25](=[O:26])[OH:27]|US20090311217A1_1758
1.2.3|[C:6]-[C&H0&+0&D3:5](-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1])=O>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H1&+0&D2:4]:1|[CH3:1][CH2:2][CH2:3][n:4]1[c:5]([n:6]([c:7]([c:8]([c:9]1=[O:10])[NH:11][C:12](=O)/[CH:13]=[CH:14]/[c:15]1[cH:16][c:17]([c:18]([c:19]([cH:20]1)[O:21][CH3:22])[O:23][CH3:24])[O:25][CH3:26])[NH2:27])[CH2:28][CH2:29][CH3:30])=[O:31]>C1COCCO1.O[Na]>[CH3:26][O:25][c:17]1[cH:16][c:15]([cH:20][c:19]([c:18]1[O:23][CH3:24])[O:21][CH3:22])/[CH:14]=[CH:13]/[c:12]1[n:27][c:7]2[c:8]([nH:11]1)[c:9]([n:4]([c:5]([n:6]2[CH2:28][CH2:29][CH3:30])=[O:31])[CH2:3][CH2:2][CH3:1])=[O:10]|US20180370972A1_2212
3.11.27|[C&H2&+0&D1:5]=[C&H0&+0&D3:4](-[C:3])-[c:2].[C&H3&+0&D1:1]-[S&+](-C)-C>>[C&H2&+0&D2:5]1-[C&H2&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C:3])-[c:2]|[I-].[CH2:1]=[C:2]([C:3]([CH3:4])=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH3:12].C[S+](C)[CH3:13]>CN(C)C=O.[NaH]>[CH3:12][c:9]1[cH:10][cH:11][c:6]([cH:7][cH:8]1)[C:2]1([CH2:1][CH2:13]1)[C:3]([CH3:4])=[O:5]|US20190077784A1_2055
1.7.20|[C:5]-[O&H1&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O-N1-C(=O)-C-C-C-1=O>>[C:5]-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[O:1]=[C:2]1[CH2:3][CH2:4][C:5]([N:6]1[O:7][C:8](=[O:9])ON1C(CCC1=O)=O)=[O:10].[N:11]#[C:12][CH2:13][CH2:14][OH:15]>>[N:11]#[C:12][CH2:13][CH2:14][O:15][C:8](=[O:9])[O:7][N:6]1[C:2]([CH2:3][CH2:4][C:5]1=[O:10])=[O:1]|US20200277312A1_0943
1.2.14|[N&H2&+0&D1:6]-[c:5].[c:4]-[C&H1&+0&D3:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[N&H1&+0&D2:6](-[c:5])-[C&H1&+0&D3:3](-[c:4])-[C:2]-[O&H1&+0&D1:1]|[CH3:1][n:2]1[n:3][c:4]([cH:5][cH:6][c:7]1=[O:8])[NH2:9].[CH3:10][C:11]1([O:12][c:13]2[cH:14][cH:15][c:16]([cH:17][c:18]2[CH:19]2[O:20][CH:21]21)[C:22]#[N:23])[CH3:24]>[Na+].CS(C)=O.[H-]>[CH3:1][n:2]1[n:3][c:4]([cH:5][cH:6][c:7]1=[O:8])[NH:9][CH:19]1[c:18]2[cH:17][c:16]([cH:15][cH:14][c:13]2[O:12][C:11]([CH:21]1[OH:20])([CH3:10])[CH3:24])[C:22]#[N:23]|US07838553B2_0728
1.7.17|[O&H1&+0&D1:6]-[c:5].[c:4]-[C&H1&+0&D3:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[O&H0&+0&D2:6](-[c:5])-[C&H1&+0&D3:3](-[c:4])-[C:2]-[O&H1&+0&D1:1]|[CH3:1][CH:2]([CH3:3])[NH:4][C:5](=[O:6])[CH:7]1[O:8][CH:9]1[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH3:16][O:17][c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[OH:24]>C1COCCOCCOCCOCCOCCO1.CC#N.[NaH]>[CH3:16][O:17][c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[O:24][CH:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[CH:7]([OH:8])[C:5](=[O:6])[NH:4][CH:2]([CH3:1])[CH3:3]|US07838553B2_0271
3.11.16|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[Cl:9].[Cl:10][c:11]1[cH:12][cH:13][cH:14][c:15]2[cH:16][c:17]([cH:18][n:19][c:20]12)I>CC(C)[Mg]Cl.N#C[Cu].C1CCOC1>[O:1]=[C:2]([c:17]1[cH:18][n:19][c:20]2[c:11]([cH:12][cH:13][cH:14][c:15]2[cH:16]1)[Cl:10])[c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[Cl:9]|US20080249091A1_0301
3.11.27|[C&H3&+0&D1:5]-[S&+](-C)-C.[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H2&+0&D2:5]1-[C@&H1&+0&D3:2](-[c:1])-[C@&H1&+0&D3:3]-1-[C:4]|[I-].[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]=[CH:7][c:8]1[cH:9][cH:10][n:11][cH:12][cH:13]1.C[S+](C)[CH3:14]>CS(C)=O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C@@H:6]1[CH2:14][C@H:7]1[c:8]1[cH:9][cH:10][n:11][cH:12][cH:13]1|US10316049B2_0843
3.9.82|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|I[c:1]1[cH:2][n:3][cH:4][cH:5][n:6]1.[CH3:7][C:8]([CH3:9])([CH3:10])[CH:11]=[O:12]>CCOCC.CCCC[Li].[NH4+].[Cl-]>[CH3:7][C:8]([CH3:9])([CH3:10])[CH:11]([OH:12])[c:1]1[cH:2][n:3][cH:4][cH:5][n:6]1|US20120330012A1_0323
3.11.16|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[n:14]1[cH:15][c:16]([cH:17][c:18]1-[c:19]1[n:20][n:21][n:22][n:23]1[C:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)([c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)[c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)Br)([c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1)[c:49]1[cH:50][cH:51][cH:52][cH:53][cH:54]1.[CH3:55][CH2:56][O:57][C:58](=[O:59])Cl>CN(C)CCN(C)C.CCCC[Li].C1CCOC1>[CH3:55][CH2:56][O:57][C:58](=[O:59])[c:16]1[cH:17][c:18]([n:14]([cH:15]1)-[c:11]1[cH:10][cH:9][c:8]([cH:13][cH:12]1)[CH2:7][O:6][Si:5]([c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1)([c:49]1[cH:50][cH:51][cH:52][cH:53][cH:54]1)[C:2]([CH3:1])([CH3:3])[CH3:4])-[c:19]1[n:20][n:21][n:22][n:23]1[C:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)([c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)[c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1|US20020193578A1_0742
3.11.39|[C&H1&+0&D1:6]#[C:5].[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H0&+0&D2:6](#[C:5])-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH:1]#[C:2][C:3]([CH3:4])([OH:5])[CH:6]=[CH:7][CH:8]=[C:9]([CH3:10])[CH:11]=[CH2:12].[CH3:13][CH:14]1[CH2:15][CH2:16][CH2:17][C:18]([C:19]1=[O:20])([CH3:21])[CH3:22]>c1ccccc1.CCOCC.CCBr.[NH4+].[Cl-].[Mg]>[CH2:12]=[CH:11][C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]([CH3:4])([OH:5])[C:2]#[C:1][C:19]1([CH:14]([CH2:15][CH2:16][CH2:17][C:18]1([CH3:21])[CH3:22])[CH3:13])[OH:20]|US20120214847A1_0324
3.11.16|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]1([O:3][CH2:4][CH2:5][O:6]1)[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)Br.[CH3:13][C:14]([CH3:15])([CH3:16])[C:17](=[O:18])Cl>BrCC1(OCCO1)c1ccccc1.C1CCOC1.[Mg]>[CH3:13][C:14]([CH3:15])([CH3:16])[C:17](=[O:18])[c:10]1[cH:9][cH:8][c:7]([cH:12][cH:11]1)[C:2]1([O:3][CH2:4][CH2:5][O:6]1)[CH3:1]|EP3498098A1_0340
3.11.1|[C&H2&+0&D1:6]=[O&H0&+0&D1:5].[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C&H2&+0&D2:6](-[O&H1&+0&D1:5])-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH2:1]=[O:2].[CH3:3][CH2:4][CH:5]1[CH2:6][c:7]2[cH:8][c:9]([c:10]([c:11]([c:12]2[C:13]1=[O:14])[Cl:15])[Cl:16])[O:17][CH2:18][C:19](=[O:20])[OH:21]>O.Cl.O[Na]>[CH3:3][CH2:4][C:5]1([CH2:6][c:7]2[cH:8][c:9]([c:10]([c:11]([c:12]2[C:13]1=[O:14])[Cl:15])[Cl:16])[O:17][CH2:18][C:19](=[O:20])[OH:21])[CH2:1][OH:2]|US20200061068A1_0116
9.7.70|[C&H3&D1:5]-[C&H0&+0&D4:4](-[C&H3&D1:3])(-[c:2])-C(-[N&H2&+0&D1:1])=O>>[C&H3&D1:5]-[C&H0&+0&D4:4](-[C&H3&D1:3])(-[N&H2&+0&D1:1])-[c:2]|[CH3:1][C:2]([CH3:3])(C([NH2:4])=O)[c:5]1[cH:6][c:7]([cH:8][c:9]([cH:10]1)[Cl:11])[Cl:12]>O.O[Na].BrBr>[CH3:1][C:2]([CH3:3])([NH2:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([cH:10]1)[Cl:11])[Cl:12]|US20160002221A1_0364
3.11.31|[C:6]-[C&H2&+0&D2:5]-[N&+:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[N&+:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][CH2:2][CH2:3][N+:4]([O-:5])=[O:6].[CH3:7][CH:8]([CH3:9])[CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[CH:17]=[O:18]>CCO.O[K]>[CH3:7][CH:8]([CH3:9])[CH2:10][c:11]1[cH:16][cH:15][c:14]([cH:13][cH:12]1)[CH:17]([OH:18])[CH:3]([CH2:2][CH3:1])[N+:4]([O-:5])=[O:6]|US10377732B2_0288
3.9.5|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|I[c:1]1[cH:2][n:3]([cH:4][n:5]1)[C:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[CH3:25][c:26]1[s:27][cH:28][cH:29][c:30]1[CH:31]=[O:32]>CC[Mg+].ClCCl.[Br-]>[CH3:25][c:26]1[s:27][cH:28][cH:29][c:30]1[CH:31]([OH:32])[c:1]1[cH:2][n:3]([cH:4][n:5]1)[C:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1|US20110319431A1_0161
1.2.18|[C&H3&+0&D1:6]-[C&H0&+0&D3:5](-[c:4])=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][s:6][cH:7]1.[CH2:8]1[CH2:9][NH:10][CH2:11][CH2:12][O:13]1>C1CCCCC1.Cl[Ti](Cl)(Cl)Cl>[CH2:1]=[C:2]([c:3]1[cH:4][cH:5][s:6][cH:7]1)[N:10]1[CH2:11][CH2:12][O:13][CH2:8][CH2:9]1|US20080280855A1_0553
2.5.7|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D3:4](-[N:3])-S-C.[C:2]-[N&H2&+0&D1:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:1]-[C:2])-[N:3]|[IH:1].[CH3:2][CH:3]([CH3:4])[NH2:5].[CH3:6][CH2:7][NH:8][C:9](=[N:10][C:11](=[NH:12])[NH2:13])SC>O>[IH:1].[CH3:6][CH2:7][NH:8][C:9](=[N:5][CH:3]([CH3:2])[CH3:4])[NH:10][C:11](=[NH:12])[NH2:13]|US04158013A
3.9.82|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C@@H:10]([CH2:11][C@H:12]1[CH:13]=[O:14])[O:15][Si:16]([CH3:17])([CH3:18])[C:19]([CH3:20])([CH3:21])[CH3:22].[Br:23][c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)I>CCCCCC.CCOC(C)=O.CCCC[Li].C1CCOC1.[NH4+].O.[Cl-]>[CH3:20][C:19]([CH3:21])([CH3:22])[Si:16]([CH3:17])([CH3:18])[O:15][C@H:10]1[CH2:9][N:8]([C@@H:12]([CH2:11]1)[CH:13]([OH:14])[c:27]1[cH:26][cH:25][c:24]([cH:29][cH:28]1)[Br:23])[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20200071322A1_0814
1.7.7|[C:6]-[C&H1&+0&D3:5](-[C:4]-[O&H0&+0&D2:3]-C)-O.[O&H1&+0&D1:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[O&H0&+0&D2:2]-[c:1])-[C:4]-[O&H1&+0&D1:3]|[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[o:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[c:13]1[C:14](=[O:15])[c:16]1[cH:17][cH:18][c:19]2[c:20]([cH:21][cH:22][c:23]([c:24]2[Br:25])[OH:26])[cH:27]1.C[O:28][C:29](=[O:30])[CH:31](O)[CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1>>[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[o:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[c:13]1[C:14](=[O:15])[c:16]1[cH:17][cH:18][c:19]2[c:20]([cH:21][cH:22][c:23]([c:24]2[Br:25])[O:26][CH:31]([CH2:32][c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[C:29](=[O:30])[OH:28])[cH:27]1|US20190152895A1_0369
2.5.7|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D3:4](-[N:3])-S-C.[N&H2&+0&D1:2]-[S:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:2]-[S:1])-[N:3]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[S:11]([NH2:12])(=[O:13])=[O:14].[CH3:15][CH2:16][N:17]=[C:18](SC)[N:19]1[CH2:20][C:21]2([CH:22]=[N:23]1)[CH2:24][CH2:25][CH2:26][CH2:27]2>CC#N>[CH3:15][CH2:16][NH:17][C:18](=[N:12][S:11](=[O:13])(=[O:14])[c:8]1[cH:7][cH:6][c:5]([cH:10][cH:9]1)[NH:4][C:2]([CH3:1])=[O:3])[N:19]1[CH2:20][C:21]2([CH:22]=[N:23]1)[CH2:24][CH2:25][CH2:26][CH2:27]2|US09422244B2_0217
9.7.262|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#19].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[N:1]#[C:2][K].[O:3]=[CH:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[O:11][CH:12]([F:13])[F:14]>O.CCO.O=S(=O)(O)O>[N:1]#[C:2][CH:4]([OH:3])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[O:11][CH:12]([F:13])[F:14]|US20180340261A1_0123
9.7.262|[C:5]-[C&H1&+0&D2:4]=[O&H0&+0&D1:3].[N&H0&D1:2]#[C&H0&+0&D2:1]-[#11]>>[C:5]-[C&H1&+0&D3:4](-[O&H1&+0&D1:3])-[C&H0&+0&D2:1]#[N&H0&D1:2]|[N:1]#[C:2][Na].[O:3]=[CH:4][CH2:5][CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1>O.CCO.O=S(O)O[Na]>[N:1]#[C:2][CH:4]([OH:3])[CH2:5][CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1|US10611740B2_0601
3.11.16|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1Br.[N:9]#[C:10][c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[C:17](=[O:18])Cl>Cl.II.C1CCOC1.[Mg]>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[C:17](=[O:18])[c:15]1[cH:14][cH:13][cH:12][c:11]([cH:16]1)[C:10]#[N:9]|EP2691372B1_0262
9.7.262|[N&H0&D1:5]#[C&H0&+0&D2:4]-[#11].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[N&H0&D1:5]#[C&H0&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[N:1]#[C:2][Na].[O-:3][N+:4](=[O:5])[c:6]1[o:7][c:8]2[c:9]([cH:10][cH:11][cH:12][c:13]2[CH:14]=[O:15])[c:16]1-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>O.CCOCC.[O-]S(=O)O.O=S(O)O[Na].ClC(Cl)Cl>[N:1]#[C:2][CH:14]([OH:15])[c:13]1[cH:12][cH:11][cH:10][c:9]2[c:8]1[o:7][c:6]([c:16]2-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[N+:4]([O-:3])=[O:5]|US20200347045A1_0638
3.11.31|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[C:3]-[C&H2&+0&D2:2]-[N&+:1]>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C&H1&+0&D3:2](-[C:3])-[N&+:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH2:11][CH2:12][N+:13]([O-:14])=[O:15].[CH3:16][O:17][c:18]1[cH:19][c:20]([cH:21][cH:22][c:23]1[O:24][CH3:25])[C:26]([C:27]#[N:28])([CH2:29][CH2:30][CH:31]=[O:32])[CH:33]([CH3:34])[CH3:35]>CC(C)O.F[K]>[CH3:16][O:17][c:18]1[cH:19][c:20]([cH:21][cH:22][c:23]1[O:24][CH3:25])[C:26]([C:27]#[N:28])([CH2:29][CH2:30][CH:31]([OH:32])[CH:12]([CH2:11][c:5]1[cH:6][cH:7][c:8]([c:3]([cH:4]1)[O:2][CH3:1])[O:9][CH3:10])[N+:13]([O-:14])=[O:15])[CH:33]([CH3:34])[CH3:35]|US10544182B2_0338
3.11.1|[C&H3&+0&D1:6]-[C:5].[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H2&+0&D2:6](-[C:5])-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:7])[C:8](=[O:9])[O:10][CH2:11][CH3:12].[CH3:13][C:14](=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)-[n:22]1[cH:23][cH:24][n:25][cH:26]1>CCO>[CH3:12][CH2:11][O:10][C:8](=[O:9])[C:6]([OH:7])([CH2:13][C:14](=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)-[n:22]1[cH:23][cH:24][n:25][cH:26]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20060003426A1_0017
3.9.5|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)I)[O:11][CH3:12].[O:13]=[CH:14][c:15]1[cH:16][cH:17][cH:18][n:19][cH:20]1>COc1ccccc1.CCOCC.[NH4+].[Cl-].[Mg]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[CH:14]([OH:13])[c:15]1[cH:20][n:19][cH:18][cH:17][cH:16]1)[O:11][CH3:12]|US09029544B2_1256
3.11.39|[C&H1&+0&D1:6]#[C:5].[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H0&+0&D2:6](#[C:5])-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH:1]#[C:2][CH2:3][O:4][CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9][O:10]1.[CH3:11][O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[CH:19]1[CH2:20][CH2:21][c:22]2[cH:23][c:24]([cH:25][cH:26][c:27]2[C:28]1=[O:29])[O:30][CH3:31]>O.C[Mg]I.C1CCOC1>[CH3:11][O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[CH:19]1[CH2:20][CH2:21][c:22]2[cH:23][c:24]([cH:25][cH:26][c:27]2[C:28]1([OH:29])[C:1]#[C:2][CH2:3][O:4][CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9][O:10]1)[O:30][CH3:31]|US08969550B2_0129
1.1.3|[C&H3&+0&D1:6]-I.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[C&H3&+0&D1:6]-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|[CH3:1]I.[O:2]=[C:3]1[c:4]2[n:5][cH:6][nH:7][c:8]2[N:9]([C:10]2=[N:11][CH2:12][CH2:13][N:14]12)[CH2:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22]>O.CCO.O[Na]>[CH3:1][n:5]1[cH:6][n:7][c:8]2[c:4]1[C:3]([N:14]1[CH2:13][CH2:12][N:11]=[C:10]1[N:9]2[CH2:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22])=[O:2]|US20200140393A1_0457
9.7.262|[C:5]-[C&H1&+0&D2:4]=[O&H0&+0&D1:3].[N&H0&D1:2]#[C&H0&+0&D2:1]-[#19]>>[C:5]-[C&H1&+0&D3:4](-[O&H1&+0&D1:3])-[C&H0&+0&D2:1]#[N&H0&D1:2]|[N:1]#[C:2][K].[O:3]=[CH:4][CH:5]1[CH2:6][N:7]([CH2:8]1)[CH:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>O.C1CCOC1>[N:1]#[C:2][CH:4]([OH:3])[CH:5]1[CH2:6][N:7]([CH2:8]1)[CH:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US08729061B2_0183
3.11.16|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])Cl.Br[c:8]1[cH:9][cH:10][c:11]2[O:12][CH2:13][O:14][c:15]2[cH:16]1>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]2[O:12][CH2:13][O:14][c:15]2[cH:16]1|US20130079320A1_0503
3.9.4|[C:6]-[C&H0&+0&D3:5](-[C:4])=[O&H0&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[O&H1&+0&D1:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([CH2:6]1)[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[F:14][c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[CH2:21]Cl>CCOCC.II.[Mg]>[OH:1][C:2]1([CH2:3][CH2:4][N:5]([CH2:6]1)[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[CH2:21][c:20]1[cH:19][cH:18][cH:17][cH:16][c:15]1[F:14]|US20170015654A1_0406
4.2.8|[C:6]-[C&H1&+0&D2:5]=[C&H0&+0&D3:4](-[C:3])-[C:2].[O&H1&+0&D1:1]-O>>[C:6]-[C&H1&+0&D3:5]1-[O&H0&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C:3])-[C:2]|[CH3:1][C:2](=[O:3])[C:4]1=[CH:5][CH2:6][CH2:7][CH2:8]1.O[OH:9]>O.CO.O[Na]>[CH3:1][C:2](=[O:3])[C:4]12[CH2:8][CH2:7][CH2:6][CH:5]1[O:9]2|EP2485737B1_0150
8.1.23|[C:6]-[C&H0&+0&D4:5](-[C:4])(-[O:3])-[C&H2&+0&D2:2]-[O&H1&+0&D1:1]>>[C:6]-[C@&H0&+0&D4:5](-[C:4])(-[O:3])-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]|[CH3:1][c:2]1[cH:3][n:4]([c:5]([nH:6][c:7]1=[O:8])=[O:9])[C@H:10]1[CH2:11][C@@H:12]([C:13]([O:14]1)([CH2:15][OH:16])[CH2:17][OH:18])[O:19][SiH2:20][C:21]([CH3:22])([CH3:23])[CH:24]([CH3:25])[CH3:26]>CCN(CC)CC.O=C(Cl)C(=O)Cl.CS(C)=O.ClCCl>[CH3:1][c:2]1[cH:3][n:4]([c:5]([nH:6][c:7]1=[O:8])=[O:9])[C@H:10]1[CH2:11][C@@H:12]([C@@:13]([O:14]1)([CH:17]=[O:18])[CH2:15][OH:16])[O:19][SiH2:20][C:21]([CH3:22])([CH3:23])[CH:24]([CH3:25])[CH3:26]|US09777035B2_0401
3.9.1|[C:6]-[C&H1&+0&D3:5](-[C:4])-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH:16]=[O:17].[CH3:18][N:19]1[O:20][CH2:21][CH:22]([C:23]1=[O:24])Br>c1ccccc1.ClCCl.Cl.[Zn]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH:16]([OH:17])[CH:22]1[CH2:21][O:20][N:19]([C:23]1=[O:24])[CH3:18]|US10364256B2_1981
3.9.4|[C:6]-[C&H2&+0&D2:5]-Cl.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH2:1]=[CH:2][CH2:3]Cl.[O:4]=[C:5]1[CH2:6][CH:7]2[CH2:8][CH:9]1[CH:10]1[CH2:11][CH2:12][CH2:13][CH:14]21>O.CC(=O)O.C1CCOC1.[Mg]>[CH2:1]=[CH:2][CH2:3][C:5]1([CH2:6][CH:7]2[CH2:8][CH:9]1[CH:10]1[CH2:11][CH2:12][CH2:13][CH:14]21)[OH:4]|US20090143611A1_0065
3.9.1|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([n:7][c:8]([c:9]([c:10]1[CH2:11][CH:12]([CH3:13])[CH3:14])[CH:15]=[O:16])[C:17]([F:18])([F:19])[F:20])[CH:21]([F:22])[F:23].Br[c:24]1[cH:25][cH:26][cH:27][s:28]1>CCOCC.II.O.Cl.[Mg]>[CH3:13][CH:12]([CH3:14])[CH2:11][c:10]1[c:5]([c:6]([n:7][c:8]([c:9]1[CH:15]([OH:16])[c:24]1[cH:25][cH:26][cH:27][s:28]1)[C:17]([F:18])([F:19])[F:20])[CH:21]([F:22])[F:23])[C:3](=[O:4])[O:2][CH3:1]|US09029544B2_2272
4.2.17|[C:6]-[C&H0&+0&D3:5](-O)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[o&H0&+0&D2:1]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[NH2:14])[OH:15].O=[C:16](O)[CH:17]([OH:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>Cc1ccccc1C>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]2[o:15][c:16]([n:14][c:12]2[cH:13]1)[CH:17]([OH:18])[c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1|US20130005707A1_1470
3.9.1|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]1([O:3][CH2:4][CH2:5][O:6]1)[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)Br.[CH3:13][C:14]([CH3:15])([CH3:16])[CH:17]=[O:18]>C1CCOC1.C1COCO1.[Mg]>[CH3:1][C:2]1([O:3][CH2:4][CH2:5][O:6]1)[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH:17]([OH:18])[C:14]([CH3:13])([CH3:15])[CH3:16]|EP2760845B1_0860
3.9.2|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][CH2:2][CH2:3]Br.[CH3:4][N:5]([CH3:6])[CH2:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][n:14]1[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22]>[NH4+].O.O.[Cl-].[Br-].CCOCC.CC[CH2-].[OH-].[OH-].[Mg].[Mg+2].[Mg+2]>[CH3:4][N:5]([CH3:6])[CH2:7][C:8]([OH:9])([CH2:3][CH2:2][CH3:1])[c:10]1[cH:11][cH:12][cH:13][n:14]1[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22]|US20200361855A1_0445
3.11.27|[C&H3&+0&D1:5]-[S&+](-C)(-C)=O.[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H2&+0&D2:5]1-[C&H1&+0&D3:2](-[c:1])-[C&H1&+0&D3:3]-1-[C:4]|[I-].C[S+](C)([CH3:1])=O.[O:2]=[C:3]([CH:4]=[CH:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[OH:12])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>CS(C)=O.O[Na]>[O:2]=[C:3]([c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)[CH:4]1[CH2:1][CH:5]1[c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[OH:12]|US20050245529A1_0571
4.2.8|[C&H2&+0&D1:5]=[C&H0&+0&D3:4](-[C&H3&D1:3])-[C:2].[O&H1&+0&D1:1]-O>>[C&H2&+0&D2:5]1-[O&H0&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C&H3&D1:3])-[C:2]|[CH2:1]=[C:2]([CH3:3])[C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[C:13]([F:14])([F:15])[F:16])[C:17]#[N:18].O[OH:19]>CC(=O)OC(C)=O.O>[CH3:3][C:2]1([CH2:1][O:19]1)[C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[C:13]([F:14])([F:15])[F:16])[C:17]#[N:18]|US20100041905A1_0125
3.9.82|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH:8]=[O:9].[CH3:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]([OH:19])/[CH:20]=[CH:21]/[c:22]1[cH:23][cH:24][cH:25][c:26]([n:27]1)Br>O.CCCC[Li].ClCCl.C1CCOC1>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH:8]([OH:9])[c:26]1[cH:25][cH:24][cH:23][c:22]([n:27]1)/[CH:21]=[CH:20]/[CH:18]([OH:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH3:10]|US20140288074A1_0373
4.1.16|[C:6]-[N&H1&+0&D2:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[C&H1&+0&D2:1](=O)-O>>[C:6]-[n&H0&+0&D3:5]1:[c&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c:3]:[c:4]:1|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH:8][CH2:9][CH2:10][CH2:11][N:12]1[CH2:13][CH2:14][CH:15]([CH2:16][CH2:17]1)[n:18]1[c:19]([nH:20][c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]21)=[O:27])[Cl:28].O=[CH:29]O>Cl>[O:27]=[c:19]1[nH:20][c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[n:18]1[CH:15]1[CH2:16][CH2:17][N:12]([CH2:13][CH2:14]1)[CH2:11][CH2:10][CH2:9][n:8]1[cH:29][n:1][c:2]2[cH:3][cH:4][c:5]([cH:6][c:7]21)[Cl:28]|US20200197391A1_0628
10.1.5|[Br&H0&+0&D1:5]-N1-C(=O)-C-C-C-1=O.[C&H3&D1:4]-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[Br&H0&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[C:22](=[O:23])[O:24][c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[CH:31]([CH3:32])[C:33](=[O:34])[O:35][CH3:36].O=C1CCC(N1[Br:37])=O>ClC(Cl)(Cl)Cl>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[C:22](=[O:23])[O:24][c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[C:31]([CH3:32])([Br:37])[C:33](=[O:34])[O:35][CH3:36]|EP2121137B1_0177
4.2.8|[C:6]-[C&H0&+0&D3:5](-[C:4])=[C&H1&+0&D2:3]-[c:2].[O&H1&+0&D1:1]-O>>[C:6]-[C&H0&+0&D4:5]1(-[C:4])-[O&H0&+0&D2:1]-[C&H1&+0&D3:3]-1-[c:2]|[O:1]=[C:2]1[C:3]([CH2:4][CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12)=[CH:12][c:13]1[cH:14][cH:15][n:16][cH:17][cH:18]1.O[OH:19]>O.Cl.CCO.[O-]S([O-])(=O)=O.ClC(Cl)Cl.[Fe+2]>[O:1]=[C:2]1[c:11]2[cH:10][cH:9][cH:8][cH:7][c:6]2[CH2:5][CH2:4][C:3]11[O:19][CH:12]1[c:13]1[cH:14][cH:15][n:16][cH:17][cH:18]1|US20190233394A1_0755
3.9.82|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]=[O:10].Br[c:11]1[cH:12][cH:13][cH:14][cH:15][n:16]1>CCOCC.CCCC[Li]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]([OH:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][n:16]1|US09029544B2_2281
3.9.1|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)Br.[CH3:11][O:12][c:13]1[cH:14][cH:15][cH:16][c:17]([cH:18]1)[CH:19]=[O:20]>CCOCC.II.[NH4+].[Cl-].[Mg]>[CH3:11][O:12][c:13]1[cH:14][cH:15][cH:16][c:17]([cH:18]1)[CH:19]([OH:20])[c:9]1[cH:10][c:5]([cH:6][cH:7][cH:8]1)[C:2]([F:1])([F:3])[F:4]|US07084149B2_0276
4.1.45|[C:6]-[N&H1&+0&D2:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[C&H1&+0&D2:1](=N)-N>>[C:6]-[n&H0&+0&D3:5]1:[c&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c:3]:[c:4]:1|CC(=O)O.[CH3:1][C@H:2]([NH:3][c:4]1[n:5][c:6]([c:7]([cH:8][c:9]1[NH2:10])[Cl:11])[NH:12][c:13]1[cH:14][c:15]([nH:16][n:17]1)[CH:18]1[CH2:19][CH2:20]1)[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[F:27].N=[CH:28]N>[Na+].CCO.CCOC(C)=O.[O-]C(=O)O>[CH3:1][C@@H:2]([c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[F:27])[n:3]1[cH:28][n:10][c:9]2[cH:8][c:7]([c:6]([n:5][c:4]21)[NH:12][c:13]1[cH:14][c:15]([nH:16][n:17]1)[CH:18]1[CH2:19][CH2:20]1)[Cl:11]|US08003806B2_0402
3.9.2|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[O:1]=[C:2]1[CH:3]2[c:4]3[cH:5][cH:6][cH:7][cH:8][c:9]3[CH:10]3[CH:11]([c:12]4[cH:13][cH:14][cH:15][cH:16][c:17]42)[CH:18]13.[CH3:19][N:20]([CH3:21])[C:22](=[O:23])[CH2:24]Br>c1ccccc1.CC(=O)O.CO.II.[Zn]>[CH3:19][N:20]([CH3:21])[C:22](=[O:23])[CH2:24][C:2]1([CH:18]2[CH:11]3[c:12]4[cH:13][cH:14][cH:15][cH:16][c:17]4[CH:3]1[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[CH:10]32)[OH:1]|US20200045972A1_0473
3.9.82|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[CH:15]=[O:16].Br[c:17]1[n:18][cH:19][cH:20][s:21]1>CCCCCC.CCOC(C)=O.CCOCC.CCCC[Li].O>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[CH:15]([OH:16])[c:17]1[n:18][cH:19][cH:20][s:21]1|EP3148995B1_0376
4.1.13|[C&H3&+0&D1:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[N&H0&+0&D2:1](=O)-O-C(-C)(-C)-C>>[c&H1&+0&D2:5]1:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c:3]:[c:4]:1|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH2:8])[C:9](=[O:10])[OH:11].CC(C)(C)O[N:12]=O>C1COCCOCCOCCOCCOCCO1.CC[O+](CC)[B-](F)(F)F.C1CCOC1.CC([O-])=O.ClC(Cl)Cl.[K+]>[O:10]=[C:9]([OH:11])[c:5]1[cH:4][cH:3][c:2]2[cH:1][n:12][nH:8][c:7]2[cH:6]1|US20200165262A1_0788
3.9.82|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[O:1]=[S:2](=[O:3])([c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10]([F:11])([F:12])[F:13])[N:14]1[CH2:15][CH2:16][C:17]2=[CH:18][c:19]3[c:20]([cH:21][n:22][n:23]3-[c:24]3[cH:25][cH:26][c:27]([cH:28][cH:29]3)[F:30])[CH2:31][C@@:32]2([CH2:33]1)[CH:34]=[O:35].[CH3:36][n:37]1[cH:38][cH:39][n:40][c:41]1Br>CCOCC.CCCC[Li].O>[CH3:36][n:37]1[cH:38][cH:39][n:40][c:41]1[CH:34]([OH:35])[C@:32]12[CH2:31][c:20]3[cH:21][n:22][n:23]([c:19]3[CH:18]=[C:17]1[CH2:16][CH2:15][N:14]([CH2:33]2)[S:2](=[O:1])(=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10]([F:11])([F:12])[F:13])-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30]|US20190100530A1_0839
4.1.16|[C:6]-[C&H0&+0&D3:5](-O)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1|[CH3:1][CH2:2][C:3](=O)O.[NH2:4][c:5]1[n:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[n:13][c:14]1[NH2:15])[Cl:16]>CCC(=O)OC(=O)CC>[CH3:1][CH2:2][c:3]1[n:4][c:5]2[n:6][c:7]3[cH:8][c:9]([cH:10][cH:11][c:12]3[n:13][c:14]2[nH:15]1)[Cl:16]|US06476041B1
4.2.8|[C:6]-[C&H1&+0&D2:5]=[C&H0&+0&D3:4](-[C:3])-[c:2].[O&H1&+0&D1:1]-O>>[C:6]-[C&H1&+0&D3:5]1-[O&H0&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C:3])-[c:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[C:9]1=[CH:10][C:11]([c:12]2[c:13]([cH:14][cH:15][cH:16][c:17]2[OH:18])[C:19]1=[O:20])=[O:21])[C:22](=[O:23])[OH:24])[CH3:25].[OH:26]O>[Na+].CO.[O-]C(=O)O>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[C:9]12[O:26][CH:10]1[C:11]([c:12]1[c:17]([cH:16][cH:15][cH:14][c:13]1[C:19]2=[O:20])[OH:18])=[O:21])[C:22](=[O:23])[OH:24])[CH3:25]|US20200039961A1_0498
3.11.89|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH2:1]=[CH:2][C:3]([CH3:4])=[O:5].[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([CH3:13])([CH3:14])[c:15]1[cH:16][cH:17][c:18]([c:19]([cH:20]1)[O:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)Br>Cl.I[Cu].C1CCOC1.[Mg]>[CH3:4][C:3](=[O:5])[CH2:2][CH2:1][c:18]1[cH:17][cH:16][c:15]([cH:20][c:19]1[O:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:12]([CH3:13])([CH3:14])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH3:6]|EP3083614B1_1697
3.9.4|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:6]-[C&H0&+0&D4:5](-[O&H1&+0&D1:4])(-[c:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[C:2]([CH2:3][CH2:4][CH2:5][Cl:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[F:13].[F:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[CH2:21]Cl>[NH4+].O.[Cl-].CCOCC.[Mg]>[OH:1][C:2]([CH2:3][CH2:4][CH2:5][Cl:6])([CH2:21][c:18]1[cH:19][cH:20][c:15]([cH:16][cH:17]1)[F:14])[c:7]1[cH:12][cH:11][c:10]([cH:9][cH:8]1)[F:13]|US20100179058A1_0161
1.9.1|[C:6]-[C&H2&+0&D2:5]-I.[O:4]-[P&H0&+0&D3:3](-[O:2])-[O&H0&+0&D2:1]-C>>[C:6]-[C&H2&+0&D2:5]-[P&H0&+0&D4:3](-[O:4])(-[O:2])=[O&H0&+0&D1:1]|[CH3:1][C:2]1([O:3][CH2:4][CH:5]([CH2:6][O:7]1)[CH2:8]I)[CH3:9].C[O:10][P:11]([O:12][CH3:13])[O:14][CH3:15]>>[CH3:15][O:14][P:11](=[O:10])([CH2:8][CH:5]1[CH2:4][O:3][C:2]([O:7][CH2:6]1)([CH3:1])[CH3:9])[O:12][CH3:13]|US20100111888A1_0103
9.5.4|[c:6]-[C&H0&+0&D4:5]1(-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1)-O>>[c:6]-[C&H1&+0&D3:5]1-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[c:2]:[c:1]-1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[CH2:7][CH2:8][C:9]([c:10]2[cH:11]1)(O)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[CH:7]=[CH:8][CH:9]([c:10]2[cH:11]1)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US06576643B2
1.9.8|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-I.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][O:10][CH2:11][C@@H:12]1[CH2:13][CH2:14][c:15]2[n:16][c:17]([cH:18][n:19]21)-[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[F:26].[CH3:27][CH2:28][CH2:29][CH2:30][Sn:31](I)([CH2:32][CH2:33][CH2:34][CH3:35])[CH2:36][CH2:37][CH2:38][CH3:39]>CCCC[Li]>[CH3:27][CH2:28][CH2:29][CH2:30][Sn:31]([CH2:32][CH2:33][CH2:34][CH3:35])([CH2:36][CH2:37][CH2:38][CH3:39])[c:18]1[c:17]([n:16][c:15]2[CH2:14][CH2:13][C@H:12]([n:19]21)[CH2:11][O:10][CH2:9][c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[O:2][CH3:1])-[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[F:26]|US10584115B2_0751
7.5.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[C&H1&+0&D3:3](-[C:2])-[N:1]>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C@@&H1&+0&D3:3](-[C:2])-[N:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH2:8][CH:9]([NH:10][C:11](=[O:12])[O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[C:21](=[O:22])[CH2:23][O:24][c:25]1[c:26]([c:27]([cH:28][c:29]([c:30]1[F:31])[F:32])[F:33])[F:34]>C1CCOC1.[Na+].[BH4-]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH2:8][C@H:9]([NH:10][C:11](=[O:12])[O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[CH:21]([OH:22])[CH2:23][O:24][c:25]1[c:26]([c:27]([cH:28][c:29]([c:30]1[F:31])[F:32])[F:33])[F:34]|US07834051B2_0877
4.2.17|[C:6]-[C&H0&+0&D3:5](-Cl)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[o&H0&+0&D2:1]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[NH2:14])[OH:15].O=[C:16](Cl)[CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>c1ccncc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]2[o:15][c:16]([n:14][c:12]2[cH:13]1)[CH2:17][c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1|US20150266857A1_0492
2.1.10|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O-C.[C:2]-[N&H1&+0&D2:1]-C(=O)-O-C(-C)(-C)-C>>[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[N&H1&+0&D2:1]-[C:2]|[CH3:1][O:2][C:3](=[O:4])[CH:5]1[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[CH:12]([N:13]1[CH2:14][CH2:15][NH:16]C(=O)OC(C)(C)C)[C:17](=[O:18])OC>Cl.CCOC(C)=O>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[CH:12]2[C:17]([NH:16][CH2:15][CH2:14][N:13]12)=[O:18]|EP2690102A1_0081
7.5.1|[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C:6]-[C@&H1&+0&D3:5](-[C:4])-[C@&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[CH2:9][CH2:10][CH:11]1[CH2:12][N:13]1[CH2:14][CH2:15][C:16]2([CH2:17][CH2:18]1)[C:19]([NH:20][CH2:21][N:22]2[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)=[O:29]>CCC(C)[BH-](C(C)CC)C(C)CC.O=C(O[K])O[K].C1CCOC1.OO.O[Na].[Li+]>[O:29]=[C:19]1[NH:20][CH2:21][N:22]([C:16]11[CH2:15][CH2:14][N:13]([CH2:18][CH2:17]1)[CH2:12][C@H:11]1[CH2:10][CH2:9][c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]2[C@H:2]1[OH:1])[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|US20190382363A1_0357
7.5.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[C:6]-[C@&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C@&H1&+0&D3:3](-[C:2])-[c:1]|[O:1]=[C:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>c1ccccc1.CCO.Cl[Na].[Na+].[BH4-]>[OH:1][C@@H:2]1[CH2:3][CH2:4][NH:5][CH2:6][C@H:7]1[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US20200061041A1_1161
7.5.1|[C:6]-[C&H1&+0&D3:5](-[N:4])-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C:6]-[C@@&H1&+0&D3:5](-[N:4])-[C&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]|[CH3:1][CH:2]([CH3:3])[C@H:4]([NH:5][C:6](=[O:7])[O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[C:16](=[O:17])[NH:18][C@@H:19]([CH3:20])[C:21](=[O:22])[NH:23][CH:24]([CH2:25][C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[C:33](=[O:34])[c:35]1[n:36][c:37]2[cH:38][cH:39][cH:40][cH:41][c:42]2[o:43]1>CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)NC(CC([O-])=O)C(=O)c1nc2ccccc2o1.O=C(O)C(F)(F)F.CCOCC.ClCCl.ClCCl.CO.N#N>[CH3:1][CH:2]([CH3:3])[C@H:4]([NH:5][C:6](=[O:7])[O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[C:16](=[O:17])[NH:18][C@@H:19]([CH3:20])[C:21](=[O:22])[NH:23][C@@H:24]([CH2:25][C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH:33]([OH:34])[c:35]1[n:36][c:37]2[cH:38][cH:39][cH:40][cH:41][c:42]2[o:43]1|US20170121338A1_0183
4.1.45|[C:6]-[C&H0&+0&D3:5](-Cl)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[NH2:9])[NH2:10].[CH3:11][CH2:12][CH2:13][CH2:14][C:15](=O)Cl>Cc1ccc(cc1)S(=O)(=O)O.CN(C)c1ccncc1.CCN(CC)CC.CCOC(C)=O.CC(=O)O.CCO>[CH3:11][CH2:12][CH2:13][CH2:14][c:15]1[n:9][c:7]2[cH:8][c:3]([cH:4][cH:5][c:6]2[nH:10]1)[O:2][CH3:1]|US10584115B2_0895
3.7.2|[C&H3&D1:5]-[C&H2&+0&D2:4]-[#12&+].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[Br-].[CH3:1][CH2:2][Mg+].[O:3]=[CH:4][c:5]1[c:6]([cH:7][cH:8][cH:9][c:10]1[Br:11])[F:12]>[NH4+].[Cl-].C1CCOC1>[CH3:1][CH2:2][CH:4]([OH:3])[c:5]1[c:6]([cH:7][cH:8][cH:9][c:10]1[Br:11])[F:12]|US20150307520A1_0326
1.9.1|[C:6]-[C&H2&+0&D2:5]-Br.[O:4]-[P&H0&+0&D3:3](-[O:2])-[O&H0&+0&D2:1]-C>>[C:6]-[C&H2&+0&D2:5]-[P&H0&+0&D4:3](-[O:4])(-[O:2])=[O&H0&+0&D1:1]|[F:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=[C:9]([CH2:10]Br)[n:11]1[cH:12][n:13][n:14][n:15]1)[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22].C[O:23][P:24]([O:25][CH3:26])[O:27][CH3:28]>>[CH3:28][O:27][P:24](=[O:23])([CH2:10][C:9](=[C:8]([c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22])[c:5]1[cH:6][cH:7][c:2]([cH:3][cH:4]1)[F:1])[n:11]1[cH:12][n:13][n:14][n:15]1)[O:25][CH3:26]|EP0188502B1_0023
1.9.8|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5](Cl)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13].[CH3:14][O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][s:21]1>CCCC[Li].C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[c:18]1[cH:19][cH:20][s:21][c:17]1[CH2:16][O:15][CH3:14]|US20200360353A1_1839
4.1.22|[C:6]-[N&H2&+0&D1:5].[C&H2&+0&D2:4](-[C:3]-[C:2]-[C&H2&+0&D2:1]-Br)-Br>>[C:6]-[N&H0&+0&D3:5]1-[C&H2&+0&D2:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-1|[NH2:1][CH:2]1[CH2:3][CH2:4][C:5]2([CH2:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[CH2:13]2)[CH2:14][CH2:15]1.Br[CH2:16][CH2:17][CH2:18][CH2:19]Br>CCOCC.ICCCCCI.ICCCCCCI.c1ccc2CC3(Cc2c1)CCC(CC3)N1CCCCC1>[cH:9]1[cH:10][cH:11][c:12]2[CH2:13][C:5]3([CH2:6][c:7]2[cH:8]1)[CH2:14][CH2:15][CH:2]([CH2:3][CH2:4]3)[N:1]1[CH2:19][CH2:18][CH2:17][CH2:16]1|US08703805B2_2016
1.9.1|[O:6]-[P&H0&+0&D3:5](-[O:4])-[O&H0&+0&D2:3]-C.[c:2]-[C&H2&+0&D2:1]-Br>>[O:6]-[P&H0&+0&D4:5](-[O:4])(-[C&H2&+0&D2:1]-[c:2])=[O&H0&+0&D1:3]|Br[CH2:1][c:2]1[cH:3][n:4][c:5]([cH:6][cH:7]1)-[c:8]1[n:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[s:16]1.C[O:17][P:18]([O:19][CH3:20])[O:21][CH3:22]>>[CH3:22][O:21][P:18](=[O:17])([CH2:1][c:2]1[cH:7][cH:6][c:5]([n:4][cH:3]1)-[c:8]1[n:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[s:16]1)[O:19][CH3:20]|US20120029224A1_0047
4.2.20|[C:6]-[C&H1&+0&D3:5](-Br)-Br.[O&H1&+0&D1:4]-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[C:6]-[C&H1&+0&D3:5]1-[O&H0&+0&D2:4]-[c:3]:[c:2]-[O&H0&+0&D2:1]-1|[CH3:1][c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[C:8](=[O:9])[c:10]1[cH:11][n:12][cH:13][cH:14][cH:15]1)[OH:16])[OH:17].[O:18]=[C:19]([OH:20])[CH:21](Br)Br>O.CS(C)=O>[CH3:1][c:2]1[cH:3][c:4]2[O:17][CH:21]([O:16][c:5]2[cH:6][c:7]1[C:8](=[O:9])[c:10]1[cH:11][n:12][cH:13][cH:14][cH:15]1)[C:19](=[O:18])[OH:20]|US20200267987A1_0421
3.7.2|[C&H2&D1:5]=[C&H1&+0&D2:4]-[#12]-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H2&D1:5]=[C&H1&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH2:1]=[CH:2][Mg]Br.[O:3]=[CH:4][c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[O:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[F:18]>Cl.C1CCOC1>[CH2:1]=[CH:2][CH:4]([OH:3])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[O:11][c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1)[F:18]|US20170217918A1_0982
3.7.2|[C&H3&D1:5]-[C&H2&+0&D2:4]-[#12]-Br.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][Mg]Br.[O:3]=[C:4]([O:5][CH:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[CH:19]1[C:20](=[CH:21][S:22][C@@H:23]2[CH:24]([C:25]([N:26]21)=[O:27])[NH:28][C:29](=[O:30])[CH2:31][c:32]1[cH:33][cH:34][cH:35][s:36]1)[CH:37]=[O:38]>Cl.CCOC(C)=O.C1CCOC1>[CH3:1][CH2:2][CH:37]([OH:38])[C:20]1=[CH:21][S:22][C@@H:23]2[CH:24]([C:25]([N:26]2[CH:19]1[C:4](=[O:3])[O:5][CH:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)=[O:27])[NH:28][C:29](=[O:30])[CH2:31][c:32]1[cH:33][cH:34][cH:35][s:36]1|US20200331968A1_0572
3.9.77|[C&H3&+0&D1:5]-[#3].[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[S:16][CH:17]([CH3:18])[C:19]([CH3:20])=[O:21].[CH3:22][Li]>>[CH3:18][CH:17]([S:16][c:7]1[cH:8][c:9]([c:10]([c:5]([cH:6]1)[C:2]([CH3:4])([CH3:3])[CH3:1])[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[C:19]([CH3:22])([CH3:20])[OH:21]|US20070099950A1_0235
1.9.8|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5](Cl)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13].[cH:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20][O:21][CH2:22][n:23]1[n:24][n:25][cH:26][n:27]1>CN(C)CCN(C)C.CCOCC.CCCC[Li].O>[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[c:26]1[n:25][n:24][n:23]([n:27]1)[CH2:22][O:21][CH2:20][c:17]1[cH:18][cH:19][cH:14][cH:15][cH:16]1|US20090048203A1_0225
3.7.2|[C&H2&D1:5]=[C&H1&+0&D2:4]-[#12]-Br.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H2&D1:5]=[C&H1&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH2:1]=[CH:2][Mg]Br.[O:3]=[CH:4][CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]1>C1CCOC1>[CH2:1]=[CH:2][CH:4]([OH:3])[CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1|US09549555B2_0105
7.5.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[C&H1&+0&D3:3](-[C:2])-[O:1]>>[C:6]-[C@@&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C@&H1&+0&D3:3](-[C:2])-[O:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[CH3:8])[O:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:14][C:15]1=[O:16])[C:17](=[O:18])[O:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>CCC(C)[BH-](C(C)CC)C(C)CC.C1CCOC1.[K+]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[CH3:8])[O:9][C@H:10]1[CH2:11][CH2:12][N:13]([CH2:14][C@H:15]1[OH:16])[C:17](=[O:18])[O:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1|US09133187B2_1083
3.7.2|[C&H1&D1:5]#[C&H0&+0&D2:4]-[#12]-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H1&D1:5]#[C&H0&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH:1]#[C:2][Mg]Br.[O:3]=[CH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[O:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[F:18]>O.O.Cl.C#C.CCBr.C1CCOC1.[Mg]>[CH:1]#[C:2][CH:4]([OH:3])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[O:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[F:18]|US20200405696A1_0804
3.7.3|[C&H2&D1:5]=[C&H1&+0&D2:4]-[#12]-Cl.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H2&D1:5]=[C&H1&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH2:1]=[CH:2][Mg]Cl.[O:3]=[CH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[O:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>[NH4+].[Cl-].Cl.C1CCOC1>[CH2:1]=[CH:2][CH:4]([OH:3])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[O:11][c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|EP1988079A1_0054
1.9.8|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[o:1]>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[o:1]|[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5](Cl)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13].[cH:14]1[cH:15][cH:16][o:17][cH:18]1>CCCC[Li].C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[c:16]1[cH:15][cH:14][cH:18][o:17]1|US20200109137A1_0302
1.9.1|[O:6]-[P&H0&+0&D3:5](-[O:4])-[O&H0&+0&D2:3]-C.[c:2]-[C&H2&+0&D2:1]-Cl>>[O:6]-[P&H0&+0&D4:5](-[O:4])(-[C&H2&+0&D2:1]-[c:2])=[O&H0&+0&D1:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([c:8]([c:9]([c:10]1[OH:11])[CH3:12])[CH2:13]Cl)[CH3:14].C[O:15][P:16]([O:17][CH3:18])[O:19][CH3:20]>CCCCCCC>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([c:8]([c:9]([c:10]1[OH:11])[CH3:12])[CH2:13][P:16](=[O:15])([O:17][CH3:18])[O:19][CH3:20])[CH3:14]|US05674482A
3.9.77|[C:6]-[C&H2&+0&D2:5]-[#3].[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:7])[CH2:8][CH:9]=[C:10]1[CH2:11][CH2:12][C@H:13]([C@@H:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21](=[O:22])[O:23][CH2:24][CH3:25])[OH:26].[CH3:27][CH2:28][CH2:29][CH2:30][Li]>[NH4+].[Cl-].CCOCC.C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:7])([CH2:30][CH2:29][CH2:28][CH3:27])[CH2:8][CH:9]=[C:10]1[CH2:11][CH2:12][C@H:13]([C@@H:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21](=[O:22])[O:23][CH2:24][CH3:25])[OH:26]|US20200062752A1_0883
3.7.2|[C&H3&D1:5]-[C&H2&+0&D2:4]-[#12]-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][CH2:2][Mg]Br.[O:3]=[CH:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[Br:11]>C=Cc1ccccc1.CCOCC>[CH3:1][CH2:2][CH:4]([OH:3])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[Br:11]|US20200045963A1_1185
3.9.77|[C&H3&+0&D1:5]-[#3].[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[Br:10].[CH3:11][Li]>[NH4+].[Cl-].CCOCC>[CH3:11][C:2]([CH3:1])([OH:3])[c:4]1[cH:9][c:8]([cH:7][cH:6][cH:5]1)[Br:10]|US20200331917A1_1307
3.9.82|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#3]>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[CH:9]=[O:10].[Cl:11][c:12]1[n:13][cH:14][cH:15][cH:16][c:17]1[Li]>O.CCCCCC.CCOCC.CCCC[Li].Clc1ncccc1Br>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[CH:9]([OH:10])[c:17]1[cH:16][cH:15][cH:14][n:13][c:12]1[Cl:11]|EP2305652A2_0171
1.2.14|[N&H4&+&D0:5].[C:4]-[C&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[N&H2&+0&D1:5]-[C&H2&+0&D2:2]-[C@&H1&+0&D3:3](-[C:4])-[O&H1&+0&D1:1]|[NH4+:1].CO.[cH:2]1[cH:3][cH:4][c:5]([cH:6][n:7]1)[O:8][CH2:9][CH:10]1[CH2:11][O:12]1>>[NH2:1][CH2:11][C@H:10]([OH:12])[CH2:9][O:8][c:5]1[cH:6][n:7][cH:2][cH:3][cH:4]1|EP3626717A1_0584
4.1.45|[C:6]-[C&H0&+0&D3:5](=N)-O-C.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1|CO[C:1](=N)[C:2]([Cl:3])([Cl:4])[Cl:5].[NH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[NH2:13]>Nc1cc(c(cc1N)Br)OC(F)(F)C(F)F.CC(=O)O.BrBr.O>[Cl:3][C:2]([Cl:4])([Cl:5])[c:1]1[n:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[nH:13]1|US20150051202A1_0456
4.1.22|[C:6]-[N&H2&+0&D1:5].[C&H2&+0&D2:4](-[c:3]:[c:2]-[C&H2&+0&D2:1]-Cl)-Cl>>[C:6]-[N&H0&+0&D3:5]1-[C&H2&+0&D2:4]-[c:3]:[c:2]-[C&H2&+0&D2:1]-1|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[O:9][CH3:10])[CH2:11]Cl)[CH2:12]Cl.[NH2:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC.Cc1ccccc1.O[Na].[Cl-]>[CH3:10][O:9][c:8]1[cH:7][c:6]2[CH2:11][N:13]([CH2:12][c:5]2[cH:4][c:3]1[O:2][CH3:1])[CH2:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|US20200339559A1_0880
7.5.1|[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C:6]-[C@&H1&+0&D3:5](-[C:4])-[C@@&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[CH2:9][CH2:10][CH:11]1[CH2:12][N:13]1[CH2:14][CH2:15][C:16]2([CH2:17][CH2:18]1)[C:19]([NH:20][CH2:21][N:22]2[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)=[O:29]>O.[Na+].CO.[BH4-]>[O:29]=[C:19]1[NH:20][CH2:21][N:22]([C:16]11[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]1)[CH2:12][C@@H:11]1[CH2:10][CH2:9][c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]2[C@H:2]1[OH:1])[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|EP0749424B1_0195
1.9.8|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][n:11]2[CH2:12][CH2:13][CH2:14][c:15]2[n:16]1.[CH3:17][CH2:18][CH2:19][CH2:20][Sn:21](Cl)([CH2:22][CH2:23][CH2:24][CH3:25])[CH2:26][CH2:27][CH2:28][CH3:29]>Cc1ccc(c(c1)[N+]([O-])=O)N/N=C1\C(C(=Cc2c1cccc2)C(=O)Nc1cccc(c1)[N+]([O-])=O)=O.CCCCCC.CCCC[Li].C1CCOC1.[NH4+].O.[Cl-]>[CH3:17][CH2:18][CH2:19][CH2:20][Sn:21]([CH2:22][CH2:23][CH2:24][CH3:25])([CH2:26][CH2:27][CH2:28][CH3:29])[c:10]1[c:9]([n:16][c:15]2[n:11]1[CH2:12][CH2:13][CH2:14]2)-[c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[O:2][CH3:1]|US20200360353A1_1681
4.1.22|[C:6]-[N&H2&+0&D1:5].[C&H2&+0&D2:4](-[c:3]:[c:2]-[C&H2&+0&D2:1]-Br)-Br>>[C:6]-[N&H0&+0&D3:5]1-[C&H2&+0&D2:4]-[c:3]:[c:2]-[C&H2&+0&D2:1]-1|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[CH2:9]Br)[CH2:10]Br.[NH2:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>[Cl-].Cc1ccccc1.CC[N+](CC)(CC)Cc1ccccc1.O[Na]>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[CH2:10][N:11]([CH2:9][c:8]21)[CH2:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|EP3290415B1_0128
3.7.3|[C&H1&D1:5]#[C&H0&+0&D2:4]-[#12]-Cl.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H1&D1:5]#[C&H0&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH:1]#[C:2][Mg]Cl.[CH3:3][N:4]([CH3:5])[CH2:6][CH2:7][CH2:8][O:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH:16]=[O:17]>O.C1CCOC1>[CH:1]#[C:2][CH:16]([OH:17])[c:13]1[cH:14][cH:15][c:10]([cH:11][cH:12]1)[O:9][CH2:8][CH2:7][CH2:6][N:4]([CH3:3])[CH3:5]|US20140045873A1_0552
7.5.1|[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C:6]-[C@@&H1&+0&D3:5](-[C:4])-[C@&H1&+0&D3:3](-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][C:18]1=[O:19]>CCC(C)[BH-](C(C)CC)C(C)CC.C1CCOC1.Cl.[K+]>[CH3:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH2:12][C@@H:13]1[CH2:14][CH2:15][CH2:16][CH2:17][C@@H:18]1[OH:19]|EP2135871A1_0150
7.5.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[C&H1&+0&D3:3](-[S:2])-[c:1]>>[C:6]-[C@@&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C@&H1&+0&D3:3](-[S:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[S:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[NH:17][C:18]([C:19]1=[O:20])=[O:21]>[Na+].Cl.CC(=O)OCC.CC(C)(C)[C@H](N)C(=O)O.C1CCOC1.[BH4-]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C@@H:9]1[S:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[NH:17][C:18]([C@@H:19]1[OH:20])=[O:21]|EP0551076A1_0042
4.1.22|[C:6]-[N&H2&+0&D1:5].[C&H2&+0&D2:4](/[C:3]=[C:2]\[C&H2&+0&D2:1]-Cl)-Cl>>[C:6]-[N&H0&+0&D3:5]1-[C&H2&+0&D2:4]-[C:3]=[C:2]-[C&H2&+0&D2:1]-1|[NH2:1][C@@H:2]([CH2:3][OH:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.Cl[CH2:11]/[CH:12]=[CH:13]\[CH2:14]Cl>>[OH:4][CH2:3][C@@H:2]([c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1)[N:1]1[CH2:11][CH:12]=[CH:13][CH2:14]1|EP1849781A1_0127
1.9.8|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5](Cl)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13].[cH:14]1[cH:15][c:16]([cH:17][s:18]1)[CH:19]1[O:20][CH2:21][CH2:22][O:23]1>CCOCC.CCCC[Li].C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[c:17]1[s:18][cH:14][cH:15][c:16]1[CH:19]1[O:20][CH2:21][CH2:22][O:23]1|EP3489236B1_0803
3.7.2|[C&H1&D1:5]#[C&H0&+0&D2:4]-[#12]-Br.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H1&D1:5]#[C&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH:1]#[C:2][Mg]Br.[CH3:3][CH2:4][CH:5]=[C:6]([CH3:7])[CH:8]=[O:9]>[NH4+].O.[Cl-].C1CCOC1>[CH:1]#[C:2][CH:8]([OH:9])[C:6]([CH3:7])=[CH:5][CH2:4][CH3:3]|US20050176800A1_0651
1.9.1|[C:6]-[C&H2&+0&D2:5]-Cl.[O:4]-[P&H0&+0&D3:3](-[O:2])-[O&H0&+0&D2:1]-C>>[C:6]-[C&H2&+0&D2:5]-[P&H0&+0&D4:3](-[O:4])(-[O:2])=[O&H0&+0&D1:1]|C[O:1][P:2]([O:3][CH3:4])[O:5][CH3:6].[CH2:7]=[CH:8][CH2:9]Cl>CCl.[Ni]>[CH2:7]=[CH:8][CH2:9][P:2](=[O:1])([O:3][CH3:4])[O:5][CH3:6]|EP2598509B1_0039
7.5.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[C&H1&+0&D3:3](-[C:2])-[c:1]>>[C:6]-[C@&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C@@&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][N:2]1[CH2:3][CH2:4][C:5]([CH:6]([CH2:7]1)[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)=[O:14]>O.[Na+].CO.[BH4-]>[CH3:1][N:2]1[CH2:3][CH2:4][C@@H:5]([C@@H:6]([CH2:7]1)[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[OH:14]|EP0014997B1_0061
3.7.3|[C&H3&D1:5]-[C&H2&+0&D2:4]-[#12]-Cl.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:5]-[C&H2&+0&D2:4]-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][CH2:2][O:3][c:4]1[cH:5][c:6]2[c:7]([cH:8][c:9]1[CH:10]=[O:11])[C:12](=[CH:13][CH2:14][C:15]2([CH3:16])[CH3:17])[C:18]([CH3:19])([CH3:20])[CH3:21].[CH3:22][CH2:23][Mg]Cl>CN1CCCN(C1=O)C.C1CCOC1>[CH3:22][CH2:23][CH:10]([OH:11])[c:9]1[cH:8][c:7]2[C:12](=[CH:13][CH2:14][C:15]([c:6]2[cH:5][c:4]1[O:3][CH2:2][CH3:1])([CH3:16])[CH3:17])[C:18]([CH3:19])([CH3:20])[CH3:21]|US10626095B2_2313
8.1.5|[C:6]-[C&H1&+0&D3:5](-[N:4])-[C@@&H1&+0&D3:3](-[C:2])-[O&H1&+0&D1:1]>>[C:6]-[C@&H1&+0&D3:5](-[N:4])-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH:4]([NH:5][C:6](=[O:7])[C@@H:8]1[C@H:9]2[CH2:10][CH2:11][CH2:12][C@H:13]2[CH2:14][N:15]1[C:16](=[O:17])[C@@H:18]([NH:19][C:20](=[O:21])[C@@H:22]([NH:23][C:24](=[O:25])[c:26]1[cH:27][n:28][cH:29][cH:30][n:31]1)[CH:32]1[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]1)[C:38]([CH3:39])([CH3:40])[CH3:41])[C@H:42]([OH:43])[C:44](=[O:45])[NH:46][CH:47]1[CH2:48][CH2:49]1>CC1(CCCC(N1[O])(C)C)C.[O-]C(=O)O.ClCCl.[O-]Cl.Br[K].[Na+].[Na+]>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:5][C:6](=[O:7])[C@@H:8]1[C@H:9]2[CH2:10][CH2:11][CH2:12][C@H:13]2[CH2:14][N:15]1[C:16](=[O:17])[C@@H:18]([NH:19][C:20](=[O:21])[C@@H:22]([NH:23][C:24](=[O:25])[c:26]1[cH:27][n:28][cH:29][cH:30][n:31]1)[CH:32]1[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]1)[C:38]([CH3:39])([CH3:40])[CH3:41])[C:42](=[O:43])[C:44](=[O:45])[NH:46][CH:47]1[CH2:48][CH2:49]1|US20150274777A1_0441
9.7.54|[Br&H0&D1:5]-[C&H0&+0&D4:4](-[Br&H0&D1:3])(-Br)-Br.[c:2]-[C&H1&+0&D2:1]=O>>[Br&H0&D1:5]-[C&H0&+0&D3:4](-[Br&H0&D1:3])=[C&H1&+0&D2:1]-[c:2]|[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]=O.Br[C:10](Br)([Br:11])[Br:12]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.ClC(Cl)(Cl)Cl.ClCCl.[Zn]>[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]=[C:10]([Br:11])[Br:12]|EP3628669A1_0319
1.8.6|[C&H3&+0&D1:5]-I.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[S&H0&+0&D2:1]-[C&H0&+0&D3:3](=[N&H1&+0&D1:4])-[N:2]|[NH2:1][C:2](=[S:3])[NH:4][CH:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[C:12]([F:13])([F:14])[F:15].[CH3:16]I>CC(C)=O>[CH3:16][S:3][C:2](=[NH:1])[NH:4][CH:5]([c:6]1[cH:11][cH:10][cH:9][cH:8][cH:7]1)[C:12]([F:13])([F:14])[F:15]|US20200339559A1_0808
10.1.6|[Br&H0&+0&D1:5]-[Br&H0&+0&D1:4].[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:5]-[C&H2&+0&D2:3]-[C&H1&+0&D3:2](-[Br&H0&+0&D1:4])-[C:1]|[CH2:1]=[CH:2][CH2:3][c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[O:10][C:11]([CH3:12])=[O:13])[F:14].[Br:15][Br:16]>S=C=S>[CH3:12][C:11](=[O:13])[O:10][c:9]1[cH:8][cH:7][c:6]([cH:5][c:4]1[CH2:3][CH:2]([Br:15])[CH2:1][Br:16])[F:14]|US20200407393A1_0298
1.2.5|[N&H4&+&D0:6].[C:5]-[C&H0&+0&D3:4](-[C&H1&+0&D3:3](-[C:2])-[N:1])=O>>[N&H2&+0&D1:6]-[C@&H1&+0&D3:4](-[C:5])-[C@@&H1&+0&D3:3](-[C:2])-[N:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH2:11][C:12]([CH:13]1[CH2:14][c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)-[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)=O.CC([O-])=O.[NH4+:27]>CC(=O)O[BH-](OC(C)=O)OC(C)=O.O=C(O)O[Na].C1CCOC1.CO.[Na+]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH2:11][C@@H:12]([C@@H:13]1[CH2:14][c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)-[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[NH2:27]|US10428023B2_1719
2.1.40|[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O-n1:n:n:c2:c:c:c:c:c:1:2.[C:2]-[N&H2&+0&D1:1]>>[C:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[CH3:1][O:2]/[N:3]=[C:4](\[C:5](=[O:6])On1nnc2c1cccc2)[c:7]1[cH:8][s:9][c:10]([n:11]1)[NH:12][C:13]([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1.[NH2:32][C@@H:33]1[C:34]([N:35]2[C@@H:36]1[S:37][CH2:38][C:39](=[C:40]2[C:41](=[O:42])[OH:43])[CH2:44][S:45][c:46]1[n:47][n:48][n:49][n:50]1[NH2:51])=[O:52]>CCN(CC)CC.CC(=O)N(C)C.O.O.O>[CH3:1][O:2]/[N:3]=[C:4](\[C:5](=[O:6])[NH:32][C@@H:33]1[C:34]([N:35]2[C@@H:36]1[S:37][CH2:38][C:39](=[C:40]2[C:41](=[O:42])[OH:43])[CH2:44][S:45][c:46]1[n:47][n:48][n:49][n:50]1[NH2:51])=[O:52])[c:7]1[cH:8][s:9][c:10]([n:11]1)[NH:12][C:13]([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1|US07560569B2_0394
3.11.31|[C&H3&+0&D1:6]-[N&+:5].[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H2&+0&D2:6](-[N&+:5])-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][N+:2]([O-:3])=[O:4].[O:5]=[C:6]1[NH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[C:14]1=[O:15]>O>[O-:3][N+:2](=[O:4])[CH2:1][C:14]1([C:6]([NH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]21)=[O:5])[OH:15]|US20130281449A1_0411
9.7.54|[Br&H0&D1:5]-[C&H0&+0&D4:4](-[Br&H0&D1:3])(-Br)-Br.[C:2]-[C&H1&+0&D2:1]=O>>[Br&H0&D1:5]-[C&H0&+0&D3:4](-[Br&H0&D1:3])=[C&H1&+0&D2:1]-[C:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][CH2:10][CH:11]=O.Br[C:12](Br)([Br:13])[Br:14]>ClCCl.[Zn]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][CH2:10][CH:11]=[C:12]([Br:13])[Br:14]|US20170355687A1_0376
3.11.31|[C&H3&+0&D1:6]-[N&+:5].[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H2&+0&D2:6](-[N&+:5])-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][N+:2]([O-:3])=[O:4].[CH3:5][CH2:6][O:7][C:8](=[O:9])[N:10]1[CH2:11][CH2:12][C:13]([CH2:14][CH2:15]1)=[O:16]>[Na+].C[O-].CO>[CH3:5][CH2:6][O:7][C:8](=[O:9])[N:10]1[CH2:11][CH2:12][C:13]([CH2:14][CH2:15]1)([OH:16])[CH2:1][N+:2]([O-:3])=[O:4]|US20200383960A1_0647
10.1.6|[Br&H0&+0&D1:5]-[Br&H0&+0&D1:4].[C&H2&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[Br&H0&+0&D1:5]-[C&H2&+0&D2:3]-[C&H1&+0&D3:2](-[Br&H0&+0&D1:4])-[c:1]|[CH2:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[Br:15][Br:16]>ClC(Cl)(Cl)Cl.O.O>[Br:15][CH2:1][CH:2]([Br:16])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1|US09061060B2_0530
1.8.6|[C&H3&+0&D1:5]-I.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](=[S&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[S&H0&+0&D2:2]-[C&H0&+0&D3:3](=[N&H1&+0&D1:4])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[NH:13][C:14](=[O:15])[NH:16][C:17](=[O:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[C:25]([NH2:26])=[S:27].[CH3:28]I>CC(C)=O>[CH3:1][O:2][C:3](=[O:4])[CH2:5][O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[NH:13][C:14](=[O:15])[NH:16][C:17](=[O:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[C:25](=[NH:26])[S:27][CH3:28]|US09738624B2_0316
7.5.1|[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C:6]-[C@@&H1&+0&D3:5](-[C:4])-[C@@&H1&+0&D3:3](-[C:2])-[O&H1&+0&D1:1]|Cl.[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][N:7]([CH2:8][CH2:9][C:10]1=[O:11])[CH2:12][CH2:13][CH:14]1[CH2:15][O:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[O:23]1>[Na+].Cl.CO.COC(=O)C1CN(CCC=1O)CCC1COc2ccccc2O1.[BH4-]>[CH3:1][O:2][C:3](=[O:4])[C@@H:5]1[CH2:6][N:7]([CH2:8][CH2:9][C@H:10]1[OH:11])[CH2:12][CH2:13][CH:14]1[CH2:15][O:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[O:23]1|US09908834B2_0735
2.5.7|[N&H2&+0&D1:6]-[c:5].[c:4]:[n&H0&+0&D2:3]:[c&H0&+0&D3:2](:[n:1])-S-C-C>>[N&H0&+0&D2:6](-[c:5])=[c&H0&+0&D3:2](:[n:1]):[n&H1&+0&D2:3]:[c:4]|[CH3:1][CH:2]([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[F:11])[NH2:12].CCS[c:13]1[n:14][c:15]([n:16]([c:17]([n:18]1[CH2:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[Cl:26])=[O:27])[CH2:28][CH2:29][S:30]([NH2:31])(=[O:32])=[O:33])=[O:34]>CC(=O)O.CC(C)(C)O>[CH3:1][CH:2]([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[F:11])[N:12]=[c:13]1[nH:14][c:15]([n:16]([c:17]([n:18]1[CH2:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[Cl:26])=[O:27])[CH2:28][CH2:29][S:30]([NH2:31])(=[O:32])=[O:33])=[O:34]|US09732060B2_0497
8.1.3|[C:6]-[C@@&H1&+0&D3:5](-[N:4])-[C@@&H1&+0&D3:3](-[C:2])-[O&H1&+0&D1:1]>>[C:6]-[C&H1&+0&D3:5](-[N:4])-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]1[CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[CH2:17][C@H:18]1[OH:19]>CC(=O)O[I]1(OC(c2ccccc21)=O)(OC(C)=O)OC(C)=O.ClCCl>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[CH2:17][C:18]1=[O:19]|US10351547B2_1385
8.1.10|[C:6]-[C@@&H1&+0&D3:5](-[O:4])-[C@@&H1&+0&D3:3](-[C:2])-[O&H1&+0&D1:1]>>[C:6]-[C&H1&+0&D3:5](-[O:4])-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]|[OH:1][C@@H:2]1[CH2:3][CH2:4][CH2:5][C@H:6]1[O:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[C:14]([F:15])([F:16])[F:17]>c1cc[nH+]cc1.CCOCC.[O-][Cr](=O)(=O)Cl.ClCCl>[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][CH:6]1[O:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[C:14]([F:15])([F:16])[F:17]|US20200392149A1_0788
4.2.20|[O&H1&+0&D1:6]-[C:5]-[C:4]-[O&H1&+0&D1:3].[O:2]-[C&H1&+0&D3:1](-O-C)-O-C>>[O&H0&+0&D2:6]1-[C:5]-[C:4]-[O&H0&+0&D2:3]-[C&H1&+0&D3:1]-1-[O:2]|CO[CH:1]([O:2][CH3:3])OC.[OH:4][CH2:5][CH:6]([OH:7])[CH2:8][Br:9]>c1ccccc1>[CH3:3][O:2][CH:1]1[O:7][CH:6]([CH2:5][O:4]1)[CH2:8][Br:9]|US06011174A
4.1.22|[N&H2&+0&D1:6]-[c:5].[C&H2&+0&D2:4](-[c:3]:[c:2]-[C&H2&+0&D2:1]-Br)-Br>>[N&H0&+0&D3:6]1(-[c:5])-[C&H2&+0&D2:4]-[c:3]:[c:2]-[C&H2&+0&D2:1]-1|Br.[CH3:1][c:2]1[n:3][cH:4][c:5]([c:6]([c:7]1[OH:8])[CH2:9]Br)[CH2:10]Br.[NH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>CO.Cc1ccccc1.ClC(Cl)Cl>[CH3:1][c:2]1[n:3][cH:4][c:5]2[CH2:10][N:11]([CH2:9][c:6]2[c:7]1[OH:8])[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US20160159774A1_0500
4.2.20|[O&H1&+0&D1:6]-[C:5]-[C:4]-[O&H1&+0&D1:3].[c:2]-[C&H1&+0&D3:1](-O-C)-O-C>>[O&H0&+0&D2:6]1-[C:5]-[C:4]-[O&H0&+0&D2:3]-[C&H1&+0&D3:1]-1-[c:2]|CO[CH:1](OC)[c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[O:8]=[C:9]1[O:10][C@@H:11]([C:12](=[C:13]1[OH:14])[OH:15])[C@@H:16]([OH:17])[CH2:18][OH:19]>CO.Cc1ccc(cc1)S(=O)(=O)O.CN(C)C=O>[O:8]=[C:9]1[O:10][C@@H:11]([C:12](=[C:13]1[OH:14])[OH:15])[C@@H:16]1[CH2:18][O:19][CH:1]([O:17]1)[c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1|US08569503B2_0637
3.11.87|[C:6]-[C&H2&+0&D2:5]-[C:4].[C&H2&+0&D2:3](-[C:2]-[C&H2&+0&D2:1]-Br)-Br>>[C:6]-[C&H0&+0&D4:5]1(-[C:4])-[C&H2&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[O:9][CH2:10][CH3:11].[CH3:12][CH2:13][CH2:14][CH:15]([CH2:16]Br)[CH2:17]Br>[Na+].CC[O-].CCO.[Na]>[CH3:11][CH2:10][O:9][C:7](=[O:8])[C:6]1([CH2:17][CH:15]([CH2:16]1)[CH2:14][CH2:13][CH3:12])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US10377748B2_0745
2.3.12|[C:6]-[N&H1&+0&D2:5]-[C:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-n1:c:c:n:c:1>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][c:2]1[n:3][n:4]([cH:5][c:6]1-[c:7]1[cH:8][cH:9][c:10]2[n:11][cH:12][cH:13][c:14]([c:15]2[cH:16]1)[N:17]1[CH2:18][CH2:19][N:20]([CH2:21][CH2:22]1)[C:23](=[O:24])n1ccnc1)[C:25]([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)([c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)[c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1.[CH2:44]1[CH2:45][NH:46][CH2:47][CH2:48][O:49]1>CCOC(C)=O.O>[CH3:1][c:2]1[n:3][n:4]([cH:5][c:6]1-[c:7]1[cH:8][cH:9][c:10]2[n:11][cH:12][cH:13][c:14]([c:15]2[cH:16]1)[N:17]1[CH2:18][CH2:19][N:20]([CH2:21][CH2:22]1)[C:23](=[O:24])[N:46]1[CH2:47][CH2:48][O:49][CH2:44][CH2:45]1)[C:25]([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)([c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)[c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1|US20190241558A1_0688
3.9.23|[C&H2&+0&D1:5]=[C&H0&+0&D3:4](-[C&H3&D1:3])-[C:2].[C&H2&+0&D2:1](-I)-I>>[C&H2&+0&D2:5]1-[C&H2&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C&H3&D1:3])-[C:2]|[CH2:1]=[C:2]([CH3:3])[CH2:4][CH2:5][C:6](=[O:7])[O:8][CH2:9][CH3:10].I[CH2:11]I>[NH4+].[Cl-].CCCCCC.CC[Zn]CC>[CH3:10][CH2:9][O:8][C:6](=[O:7])[CH2:5][CH2:4][C:2]1([CH2:1][CH2:11]1)[CH3:3]|US20190100530A1_0307
2.3.7|[C:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[n:1])-n1:c:c:n:c:1>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[n:1]|[CH3:1][C:2](=[O:3])[NH:4][CH2:5][C@H:6]1[CH2:7][N:8]([C:9]([O:10]1)=[O:11])[c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[F:18])[N:19]1[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1.[O:25]=[C:26]([n:27]1[cH:28][n:29][cH:30][cH:31]1)n1cncc1>Cc1ccccc1.O=C(O[K])O[K]>[CH3:1][C:2](=[O:3])[NH:4][CH2:5][C@H:6]1[CH2:7][N:8]([C:9]([O:10]1)=[O:11])[c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[F:18])[N:19]1[CH2:20][CH2:21][N:22]([CH2:23][CH2:24]1)[C:26](=[O:25])[n:27]1[cH:31][cH:30][n:29][cH:28]1|US20200157095A1_0427
3.9.23|[C:6]-[C&H1&+0&D2:5]=[C&H0&+0&D3:4](-[C:3])-[c:2].[C&H2&+0&D2:1](-I)-I>>[C:6]-[C&H1&+0&D3:5]1-[C&H2&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C:3])-[c:2]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8]1=[CH:9][CH2:10][NH:11][CH2:12]1.I[CH2:13]I>c1ccccc1.[Cu]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8]12[CH2:12][NH:11][CH2:10][CH:9]1[CH2:13]2|US20140357725A1_0151
4.1.22|[N&H2&+0&D1:6]-[c:5].[C&H2&+0&D2:4](-[C:3]-[C:2]-[C&H2&+0&D2:1]-Br)-Br>>[N&H0&+0&D3:6]1(-[c:5])-[C&H2&+0&D2:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-1|[NH2:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[Cl:8])[O:9][C:10]12[CH2:11][CH:12]3[CH2:13][CH:14]([CH2:15][CH:16]([CH2:17]3)[CH2:18]1)[CH2:19]2.Br[CH2:20][CH2:21][CH2:22][CH2:23]Br>O=C(O[K])O[K].CCO>[Cl:8][c:6]1[cH:7][c:2]([cH:3][cH:4][c:5]1[O:9][C:10]12[CH2:19][CH:14]3[CH2:13][CH:12]([CH2:17][CH:16]([CH2:15]3)[CH2:18]1)[CH2:11]2)[N:1]1[CH2:23][CH2:22][CH2:21][CH2:20]1|US08058045B2_1644
2.1.2|[C&H3&D1:6]-[N&H2&+&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][n:2]1[n:3][c:4]([cH:5][c:6]1[C:7]#[N:8])[CH2:9][NH2+:10][CH3:11].[O:12]=[C:13](O)[c:14]1[cH:15][cH:16][c:17]([cH:18][c:19]1[OH:20])[F:21].[Cl-]>CN(C)C(On1nnc2cccnc21)=[N+](C)C.CCN(C(C)C)C(C)C.F[P-](F)(F)(F)(F)F.CN(C)C=O>[CH3:11][N:10]([CH2:9][c:4]1[cH:5][c:6]([n:2]([n:3]1)[CH3:1])[C:7]#[N:8])[C:13](=[O:12])[c:14]1[cH:15][cH:16][c:17]([cH:18][c:19]1[OH:20])[F:21]|US20090062251A1_0424
2.1.27|[C:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-n1:c:c:n:c:1>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][N:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1.[CH3:8][O:9][N:10]=[C:11]([C:12](=[O:13])[NH:14][CH:15]1[C:16]([N:17]2[C@@H:18]1[S:19]([CH2:20][C:21](=[C:22]2[C:23](=[O:24])[O:25][CH:26]([c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1)[CH2:39][O:40][C:41](=[O:42])n1ccnc1)=[O:43])=[O:44])[c:45]1[cH:46][s:47][c:48]([n:49]1)[NH:50][CH:51]=[O:52]>O.CCOC(C)=O.C1CCOC1>[CH3:8][O:9][N:10]=[C:11]([C:12](=[O:13])[NH:14][CH:15]1[C:16]([N:17]2[C@@H:18]1[S:19]([CH2:20][C:21](=[C:22]2[C:23](=[O:24])[O:25][CH:26]([c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1)[CH2:39][O:40][C:41](=[O:42])[N:5]1[CH2:4][CH2:3][N:2]([CH2:7][CH2:6]1)[CH3:1])=[O:43])=[O:44])[c:45]1[cH:46][s:47][c:48]([n:49]1)[NH:50][CH:51]=[O:52]|US20200102324A1_1485
4.1.47|[C:6]-[N&H1&+0&D2:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[N&H0&+0&D2:1](-[O&-])=O>>[C:6]-[n&H0&+0&D3:5]1:[n&H0&+0&D2:1]:[n&H0&+0&D2:2]:[c:3]:[c:4]:1|[Na+].[CH3:1][O:2][CH:3]([O:4][CH3:5])[CH:6]([CH3:7])[NH:8][c:9]1[cH:10][c:11]([cH:12][cH:13][c:14]1[NH2:15])[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[O-][N:24]=O>O.COCCOC.CC(=O)O>[CH3:1][O:2][CH:3]([O:4][CH3:5])[CH:6]([CH3:7])[n:8]1[n:24][n:15][c:14]2[cH:13][cH:12][c:11]([cH:10][c:9]21)[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|EP2411387B1_0607
3.9.61|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-[#30&+]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[I-].[CH3:1][CH:2]([CH3:3])[C:4](=[O:5])Cl.[N:6]#[C:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[Zn+]>[C-]#N.[C-]#N.Br[Li].C1CCOC1.[Cu+2]>[CH3:1][CH:2]([CH3:3])[C:4](=[O:5])[c:12]1[cH:11][cH:10][cH:9][c:8]([cH:13]1)[C:7]#[N:6]|US20110136973A1_0135
1.2.14|[N&H3&+0&D0:5].[C:4]-[C@@&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[N&H2&+0&D1:5]-[C&H2&+0&D2:2]-[C&H1&+0&D3:3](-[C:4])-[O&H1&+0&D1:1]|[NH3:1].[CH3:2][c:3]1[cH:4][c:5]([n:6][c:7]([n:8]1)[NH:9][CH:10]([CH3:11])[CH3:12])-[c:13]1[n:14][o:15][c:16]([n:17]1)-[c:18]1[cH:19][c:20]([c:21]([c:22]([cH:23]1)[CH3:24])[O:25][CH2:26][C@@H:27]1[CH2:28][O:29]1)[CH2:30][CH3:31]>CO>[CH3:31][CH2:30][c:20]1[cH:19][c:18]([cH:23][c:22]([c:21]1[O:25][CH2:26][CH:27]([OH:29])[CH2:28][NH2:1])[CH3:24])-[c:16]1[n:17][c:13]([n:14][o:15]1)-[c:5]1[cH:4][c:3]([n:8][c:7]([n:6]1)[NH:9][CH:10]([CH3:11])[CH3:12])[CH3:2]|US20170210751A1_1163
3.9.23|[C&H2&+0&D1:5]=[C&H0&+0&D3:4](-[C&H3&D1:3])-[c:2].[C&H2&+0&D2:1](-I)-I>>[C&H2&+0&D2:5]1-[C&H2&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C&H3&D1:3])-[c:2]|[CH2:1]=[C:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Br:10].I[CH2:11]I>CCCCC.CC[Zn]CC.O=C(O)C(F)(F)F.ClCCl>[CH3:3][C:2]1([CH2:1][CH2:11]1)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Br:10]|EP3077378B1_0117
4.2.20|[C:6]-[C&H1&+0&D3:5](-O-C)-O-C.[O&H1&+0&D1:4]-[C:3]-[C:2]-[O&H1&+0&D1:1]>>[C:6]-[C&H1&+0&D3:5]1-[O&H0&+0&D2:4]-[C:3]-[C:2]-[O&H0&+0&D2:1]-1|[CH3:1][N:2]([CH2:3][CH:4](OC)OC)[C:5](=[O:6])[CH2:7][Cl:8].[OH:9][CH2:10][CH2:11][OH:12]>CO.CCOCC.Cc1ccc(cc1)S(=O)(=O)O.O=C(O[Na])O[Na]>[CH3:1][N:2]([CH2:3][CH:4]1[O:12][CH2:11][CH2:10][O:9]1)[C:5](=[O:6])[CH2:7][Cl:8]|US05789394A
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[N&H2&D1:3]-[N&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[N&H2&D1:3])-[c:1]|[CH3:1][C:2]([CH2:3][OH:4])([CH2:5][OH:6])[C:7](=[O:8])O.[CH3:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[NH:16][NH2:17]>C(=NC1CCCCC1)=NC1CCCCC1.C1CCOC1>[CH3:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[N:16]([NH2:17])[C:7](=[O:8])[C:2]([CH3:1])([CH2:3][OH:4])[CH2:5][OH:6]|US20180305359A1_1373
1.2.16|[C&H3&D1:6]/[C&H1&+0&D2:5]=[C&H1&+0&D2:4]/[C:3].[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[N&H1&+0&D2:2]-[c:1])-[C&H2&+0&D2:4]-[C:3]|[CH3:1]/[CH:2]=[CH:3]/[C:4](=[O:5])[OH:6].[NH2:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[Cl:14]>>[CH3:1][CH:2]([CH2:3][C:4](=[O:5])[OH:6])[NH:7][c:8]1[cH:13][c:12]([cH:11][cH:10][cH:9]1)[Cl:14]|EP3689860A1_0425
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]-[N&H1&+0&D2:2]-[O&H1&D1:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[O&H1&D1:1]|[O:1]=[P:2]([OH:3])([OH:4])[CH2:5][CH2:6][CH2:7][NH:8][OH:9].[O:10]=[C:11](O)[C:12]([F:13])([F:14])[F:15]>O=C(OC(=O)C(F)(F)F)C(F)(F)F.CCO.N.O>[O:1]=[P:2]([OH:3])([OH:4])[CH2:5][CH2:6][CH2:7][N:8]([OH:9])[C:11](=[O:10])[C:12]([F:13])([F:14])[F:15]|EP0418038A1_0217
2.4.2|[C:6]-[O&H1&+0&D1:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[S:1]>>[C:6]-[O&H0&+0&D2:5]-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[S:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[N:11]=[C:12]=[O:13].[OH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]/[CH:20]=[C:21](\[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[c:28]1[cH:29][n:30][cH:31][cH:32][cH:33]1>ClCCl>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][C:12](=[O:13])[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]/[CH:20]=[C:21](\[c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1)[c:28]1[cH:33][cH:32][cH:31][n:30][cH:29]1|US04500675A
3.11.34|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H3&D1:4])=O.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H3&D1:4])=[C&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[O:9][CH2:10][CH3:11].[CH3:12][C:13]([CH3:14])=O>CC(=O)OC(C)=O.c1ccccc1.Cl[Zn]Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[C:13]([CH3:12])[CH3:14])[C:7](=[O:8])[O:9][CH2:10][CH3:11]|EP3613743A1_0423
2.1.2|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([cH:7][nH:8][c:9]2[cH:10][c:11]1[Cl:12])[CH2:13][CH2:14][NH:15][C:16]([CH3:17])=[O:18].[CH3:19][C:20](=[O:21])O>O.CC(=O)Cl.CN(C)C=O.[NaH]>[CH3:19][C:20](=[O:21])[n:8]1[cH:7][c:6]([c:5]2[cH:4][c:3]([c:11]([cH:10][c:9]21)[Cl:12])[O:2][CH3:1])[CH2:13][CH2:14][NH:15][C:16]([CH3:17])=[O:18]|US20090326229A1_0596
1.2.17|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[S:3].[N&H2&+0&D1:2]-[O&H1&D1:1]>>[C:6]-[C&H1&+0&D3:5](-[N&H1&+0&D2:2]-[O&H1&D1:1])-[C&H2&+0&D2:4]-[S:3]|[NH2:1][OH:2].[O:3]=[S:4](=[O:5])([CH:6]=[CH:7][CH2:8][CH2:9][CH2:10][c:11]1[n:12][cH:13][cH:14][cH:15][n:16]1)[N:17]1[CH2:18][CH2:19][N:20]([CH2:21][CH2:22]1)[c:23]1[cH:24][cH:25][c:26]([cH:27][n:28]1)[C:29]#[C:30][c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[F:37]>C1CCOC1>[O:3]=[S:4](=[O:5])([CH2:6][CH:7]([CH2:8][CH2:9][CH2:10][c:11]1[n:12][cH:13][cH:14][cH:15][n:16]1)[NH:1][OH:2])[N:17]1[CH2:18][CH2:19][N:20]([CH2:21][CH2:22]1)[c:23]1[cH:24][cH:25][c:26]([cH:27][n:28]1)[C:29]#[C:30][c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[F:37]|US20060173041A1_0336
2.3.1|[C:6]-[N&H2&+0&D1:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][CH2:2][CH2:3][N:4]1[CH2:5][CH2:6][NH:7][C:8]1=[O:9].[O:10]=[C:11]=[N:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>c1ccccc1>[O:9]=[C:8]1[NH:7][CH2:6][CH2:5][N:4]1[CH2:3][CH2:2][NH:1][C:11](=[O:10])[NH:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|EP0344425A2_0048
2.3.1|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[C:2]-[N&H2&+0&D1:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[CH3:1][O:2][C:3](=[O:4])[N:5]=[C:6]([NH2:7])[O:8][CH3:9].[CH3:10][CH:11]([CH3:12])[N:13]=[C:14]=[O:15]>CCN(CC)CC.CN(C)C=O.ClCCl>[CH3:1][O:2][C:3](=[O:4])[N:5]=[C:6]([NH:7][C:14](=[O:15])[NH:13][CH:11]([CH3:10])[CH3:12])[O:8][CH3:9]|US06838454B2_00210
2.1.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[O:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[O:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][c:7]([n:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[C:16](=[O:17])O.[CH3:18][O:19][NH:20][CH3:21].Cl>CN1CCCCC1.CN(C)C=O.C(C#[O+])#[O+].ClCCl.[Cl-].[Cl-]>[CH3:18][O:19][N:20]([CH3:21])[C:16](=[O:17])[c:7]1[n:8][c:9]([c:10]([c:5]([n:6]1)[C:2]([CH3:1])([CH3:3])[CH3:4])[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15]|US06232338B1
1.3.8|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-F>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][NH:2][CH3:3].[OH:4][CH2:5][c:6]1[c:7]([c:8]([n:9][c:10]([c:11]1[F:12])F)[F:13])[F:14]>O.CCO>[CH3:1][N:2]([CH3:3])[c:10]1[n:9][c:8]([c:7]([c:6]([c:11]1[F:12])[CH2:5][OH:4])[F:14])[F:13]|US20180093956A1_0293
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([C@@H:9]([CH2:10][CH2:11][CH2:12][NH:13][C:14](=[NH:15])[NH2:16])[C:17](=[O:18])O)[N+:19]([O-:20])=[O:21].[CH3:22][CH2:23][CH2:24][CH2:25][NH:26][CH3:27]>CC(C)COC(=O)Cl.CCN(CC)CC.C1CCOC1>[CH3:22][CH2:23][CH2:24][CH2:25][N:26]([CH3:27])[C:17](=[O:18])[C@H:9]([CH2:10][CH2:11][CH2:12][NH:13][C:14](=[NH:15])[NH2:16])[N:8]([C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[N+:19]([O-:20])=[O:21]|US20200131669A1_1825
2.4.2|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[C:2]-[O&H1&+0&D1:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH2:2][N:3]1[CH2:4][CH2:5][CH:6]([N:7]([C:8]1=[O:9])[c:10]1[n:11][n:12][c:13]([s:14]1)[O:15][CH3:16])[OH:17].[O:18]=[C:19]=[N:20][CH:21]1[CH2:22][CH2:23]1>CCN(CC)CC>[CH3:1][CH2:2][N:3]1[CH2:4][CH2:5][CH:6]([N:7]([C:8]1=[O:9])[c:10]1[n:11][n:12][c:13]([s:14]1)[O:15][CH3:16])[O:17][C:19](=[O:18])[NH:20][CH:21]1[CH2:22][CH2:23]1|US20110275670A1_0145
2.4.2|[C:6]-[O&H1&+0&D1:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:6]-[O&H0&+0&D2:5]-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH2:1]=[CH:2][CH2:3][N:4]1[CH2:5][CH2:6][CH:7]([N:8]([C:9]1=[O:10])[c:11]1[n:12][n:13][c:14]([s:15]1)[S:16]([CH3:17])(=[O:18])=[O:19])[OH:20].[O:21]=[C:22]=[N:23][c:24]1[cH:25][cH:26][cH:27][c:28]([cH:29]1)[Cl:30]>CCN(CC)CC>[CH2:1]=[CH:2][CH2:3][N:4]1[CH2:5][CH2:6][CH:7]([N:8]([C:9]1=[O:10])[c:11]1[n:12][n:13][c:14]([s:15]1)[S:16]([CH3:17])(=[O:18])=[O:19])[O:20][C:22](=[O:21])[NH:23][c:24]1[cH:25][cH:26][cH:27][c:28]([cH:29]1)[Cl:30]|US20040102634A1_2066
3.7.2|[C&H3&+0&D1:5]-[#12&+].[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[O&H1&+0&D1:2])-[c:1]|[Br-].[CH3:1][O:2][c:3]1[n:4][c:5]([c:6]([cH:7][c:8]1[NH:9][C:10](=[O:11])[N:12]1[CH2:13][CH2:14][N:15]([CH2:16][CH2:17]1)[c:18]1[cH:19][c:20]([cH:21][c:22]([cH:23]1)[O:24][CH3:25])[O:26][CH3:27])[C:28]([CH3:29])=[O:30])[CH3:31].[CH3:32][Mg+]>C1CCOC1>[CH3:25][O:24][c:22]1[cH:21][c:20]([cH:19][c:18]([cH:23]1)[N:15]1[CH2:16][CH2:17][N:12]([CH2:13][CH2:14]1)[C:10](=[O:11])[NH:9][c:8]1[cH:7][c:6]([c:5]([n:4][c:3]1[O:2][CH3:1])[CH3:31])[C:28]([CH3:32])([CH3:29])[OH:30])[O:26][CH3:27]|EP2611771B1_0366
3.11.91|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-I.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2](=[CH:3][CH2:4][C:5](=[O:6])[OH:7])[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[CH3:14][CH:15]([CH3:16])I>CC(C)NC(C)C.CCCCCC.CCCC[Li].C1CCOC1.O>[CH3:1][C:2](=[CH:3][CH:4]([C:5](=[O:6])[OH:7])[CH:15]([CH3:14])[CH3:16])[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US20200129627A1_1917
2.3.2|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[S&H0&D1:3].[N&H2&+0&D1:2]-[c:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[S&H0&D1:3]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH2:8].[CH3:9][O:10][C:11](=[O:12])[N:13]=[C:14]=[S:15]>c1ccccc1>[CH3:9][O:10][C:11](=[O:12])[NH:13][C:14](=[S:15])[NH:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH2:8]|US07790729B2_1065
2.1.2|[C:6]-[N&H1&+0&D2:5]-[O&H1&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:6]-[N&H0&+0&D3:5](-[O&H1&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=[O:12])O.[CH3:13][c:14]1[cH:15][cH:16][c:17]([o:18]1)[CH:19]([CH3:20])[NH:21][OH:22]>CCN(CC)CC.CN(C)C=O.C(C#[O+])#[O+].ClCCl.[Cl-].[Cl-].Cl>[CH3:13][c:14]1[cH:15][cH:16][c:17]([o:18]1)[CH:19]([CH3:20])[N:21]([OH:22])[C:11](=[O:12])[c:8]1[cH:7][cH:6][c:5]([cH:10][cH:9]1)[S:2]([CH3:1])(=[O:3])=[O:4]|US20180222905A1_1054
1.2.5|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H3&D1:4])=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH:11]1[CH2:12][CH2:13][CH2:14][NH:15][CH2:16]1.[CH3:17][C:18]([CH3:19])=O>CC(C)I.O([Ag])[Ag]>[CH3:10][O:9][c:8]1[cH:7][cH:6][c:5]([cH:4][c:3]1[O:2][CH3:1])[CH:11]1[CH2:12][CH2:13][CH2:14][N:15]([CH2:16]1)[CH:18]([CH3:17])[CH3:19]|US20200087296A1_0324
7.6.1|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H3&D1:4])=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][C:2]([CH3:3])=[C:4]1[CH2:5][CH2:6][O:7][C:8]1=[O:9]>CCOC(C)=O.[Pd]>[CH3:1][CH:2]([CH3:3])[CH:4]1[CH2:5][CH2:6][O:7][C:8]1=[O:9]|US06414187B1
2.4.2|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[O&H1&+0&D1:2]-[c:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH2:1]=[C:2]([CH3:3])[C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[OH:13].[CH3:14][C:15]([CH3:16])([CH3:17])[CH2:18][C:19]([CH3:20])([CH3:21])[N:22]=[C:23]=[O:24]>CCN(CC)CC.CCCCCC.CCOC(C)=O.c1ccccc1>[CH2:1]=[C:2]([CH3:3])[C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[O:13][C:23](=[O:24])[NH:22][C:19]([CH3:21])([CH3:20])[CH2:18][C:15]([CH3:14])([CH3:16])[CH3:17]|US08765779B2_0498
2.4.2|[O&H0&D1:6]=[C&H0&+0&D2:5]=[N&H0&+0&D2:4]-[c:3].[O&H1&+0&D1:2]-[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O&H0&+0&D2:2]-[c:1])-[N&H1&+0&D2:4]-[c:3]|[CH2:1]=[C:2]([CH3:3])[C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[OH:13].[O:14]=[C:15]=[N:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>CCOC(C)=O.CCN(CC)CC>[CH2:1]=[C:2]([CH3:3])[C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[O:13][C:15](=[O:14])[NH:16][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|US20040229949A1_0950
1.6.8|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-I.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][O:4][c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[O:11][CH3:12])[CH2:13][NH:14][c:15]1[c:16]([n:17][nH:18][c:19]([c:20]1[Cl:21])=[O:22])[N+:23]([O-:24])=[O:25].[CH3:26][CH:27]([CH3:28])I>CCC(C)=O.O=C(O[K])O[K]>[CH3:1][CH2:2][CH2:3][O:4][c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[O:11][CH3:12])[CH2:13][NH:14][c:15]1[c:16]([n:17][n:18]([c:19]([c:20]1[Cl:21])=[O:22])[CH:27]([CH3:26])[CH3:28])[N+:23]([O-:24])=[O:25]|EP3722298A1_0101
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][NH:2][CH2:3][CH:4]([OH:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[F:12].[CH3:13][C:14]([CH3:15])([CH3:16])[O:17][C:18](=[O:19])O>CCOC(C)=O.O=C(O)O[Na].C1CCOC1>[CH3:13][C:14]([CH3:15])([CH3:16])[O:17][C:18](=[O:19])[N:2]([CH3:1])[CH2:3][CH:4]([OH:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[F:12]|US20200299273A1_0319
2.3.1|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[N&H2&+0&D1:2]-[N:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N:1])=[O&H0&D1:3]|[O:1]=[C:2]=[N:3][CH:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[O:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21.[CH3:18][CH2:19][O:20][C:21](=[O:22])[NH:23][NH2:24]>[N-]=[N+]=NC(=O)C1c2ccccc2Oc2ccccc21.c1ccccc1>[CH3:18][CH2:19][O:20][C:21](=[O:22])[NH:23][NH:24][C:2](=[O:1])[NH:3][CH:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[O:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21|US20100004235A1_0274
10.1.7|[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C:3].[Cl&H0&+0&D1:2]-[Cl&H0&+0&D1:1]>>[C&H2&+0&D2:5](-[Cl&H0&+0&D1:2])-[C&H1&+0&D3:4](-[C:3])-[Cl&H0&+0&D1:1]|[CH2:1]=[CH:2][CH2:3][S:4](=[O:5])(=[O:6])[O:7][CH3:8].[Cl:9][Cl:10]>ClC(Cl)Cl>[CH3:8][O:7][S:4](=[O:5])(=[O:6])[CH2:3][CH:2]([Cl:9])[CH2:1][Cl:10]|US06911513B2_0112
1.2.9|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-O.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[F:1][c:2]1[n:3][c:4]([c:5]2[n:6][cH:7][nH:8][c:9]2[n:10]1)[Cl:11].[CH3:12][CH:13]([CH3:14])O>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)/N=N/C(=O)OCC>[CH3:12][CH:13]([CH3:14])[n:8]1[cH:7][n:6][c:5]2[c:4]([n:3][c:2]([n:10][c:9]21)[F:1])[Cl:11]|US07507736B2_0393
2.1.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[O:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[O:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][O:2][NH:3][CH3:4].[CH3:5][c:6]1[c:7]([cH:8][cH:9][cH:10][c:11]1[C:12](=[O:13])[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20])[CH2:21][C:22](=[O:23])O>ClC(Cl)Cl.C(=NC1CCCCC1)=NC1CCCCC1>[CH3:1][O:2][N:3]([CH3:4])[C:22](=[O:23])[CH2:21][c:7]1[cH:8][cH:9][cH:10][c:11]([c:6]1[CH3:5])[C:12](=[O:13])[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20]|US09061994B1_0524
1.6.8|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-I.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]([CH3:3])I.[O:4]=[C:5]1[CH2:6][CH2:7][CH2:8][CH:9]2[NH:10][CH2:11][CH2:12][c:13]3[c:14]2[n:15]1[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]13>CC#N.O=C(O[K])O[K]>[CH3:1][CH:2]([CH3:3])[N:10]1[CH2:11][CH2:12][c:13]2[c:21]3[cH:20][cH:19][cH:18][cH:17][c:16]3[n:15]3[C:5]([CH2:6][CH2:7][CH2:8][CH:9]1[c:14]23)=[O:4]|EP2488529B1_0320
1.2.17|[C&H3&D1:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[C:3].[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[N&H1&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[C:3]|[CH3:1][CH:2]=[CH:3][C:4]#[N:5].[CH3:6][CH2:7][NH2:8]>>[CH3:6][CH2:7][NH:8][CH:2]([CH3:1])[CH2:3][C:4]#[N:5]|US20140288040A1_1587
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[O:9]=[C:10](O)[CH2:11][Cl:12]>O.O=P(Cl)(Cl)Cl>[CH3:1][N:2]([C:10](=[O:9])[CH2:11][Cl:12])[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|US20190315711A1_0381
2.4.3|[C:6]-[O&H1&+0&D1:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:6]-[O&H0&+0&D2:5]-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[N:9]=[C:10]=[S:11].[OH:12][CH2:13][c:14]1[cH:15][n:16][cH:17][cH:18][cH:19]1>O.COCCOC.NC(N)=S.O=C(O)O[Na].[NaH]>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:9][C:10](=[S:11])[O:12][CH2:13][c:14]1[cH:19][cH:18][cH:17][n:16][cH:15]1|EP1529038B1_0056
3.7.5|[C&H3&+0&D1:5]-[#12]-I.[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[n:6][c:7]([c:8]([n:9]1[C:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:29]#[N:30])[C:31]([CH3:32])=[O:33].[CH3:34][Mg]I>C1CCOC1.[NH4+].[Cl-]>[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[n:6][c:7]([c:8]([n:9]1[C:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:29]#[N:30])[C:31]([CH3:34])([CH3:32])[OH:33]|US10308637B2_1935
2.3.1|[C:6]-[N&H2&+0&D1:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[S:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[S:1]|[CH3:1][O:2][c:3]1[n:4][c:5]([n:6][c:7]([n:8]1)[CH2:9][NH2:10])[O:11][CH3:12].[CH3:13][N:14]([CH3:15])[S:16](=[O:17])(=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[S:25](=[O:26])(=[O:27])[N:28]=[C:29]=[O:30]>CC#N>[CH3:1][O:2][c:3]1[n:4][c:5]([n:6][c:7]([n:8]1)[CH2:9][NH:10][C:29](=[O:30])[NH:28][S:25](=[O:26])(=[O:27])[c:24]1[cH:23][cH:22][cH:21][cH:20][c:19]1[S:16](=[O:17])(=[O:18])[N:14]([CH3:13])[CH3:15])[O:11][CH3:12]|US20090227555A2_0894
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][NH:2][CH:3]1[CH2:4][CH2:5][N:6]([CH2:7][CH2:8]1)[CH2:9][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1.[CH3:16][O:17][c:18]1[cH:19][c:20]([c:21]([cH:22][c:23]1[C:24](=[O:25])O)[Cl:26])[NH2:27]>CCN(CC)CC.CCOC(=O)Cl.CN(C)C=O.O=C(O)O[Na].C1CCOC1>[CH3:16][O:17][c:18]1[cH:19][c:20]([c:21]([cH:22][c:23]1[C:24](=[O:25])[N:2]([CH3:1])[CH:3]1[CH2:4][CH2:5][N:6]([CH2:7][CH2:8]1)[CH2:9][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1)[Cl:26])[NH2:27]|US06495551B1
3.11.34|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H3&D1:4])=O.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H3&D1:4])=[C&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][C:2]([CH3:3])=O.[O:4]=[C:5]1[CH2:6][c:7]2[cH:8][c:9]3[n:10][c:11]([nH:12][c:13]3[cH:14][c:15]2[NH:16]1)-[c:17]1[cH:18][cH:19][n:20][cH:21][cH:22]1>N.O.CCO>[CH3:1][C:2]([CH3:3])=[C:6]1[C:5]([NH:16][c:15]2[cH:14][c:13]3[nH:12][c:11]([n:10][c:9]3[cH:8][c:7]12)-[c:17]1[cH:18][cH:19][n:20][cH:21][cH:22]1)=[O:4]|US20040142933A1_0151
2.4.3|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[S&H0&D1:3].[C:2]-[O&H1&+0&D1:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[O&H0&+0&D2:1]-[C:2])=[S&H0&D1:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]=[C:7]=[S:8].[CH3:9][CH2:10][CH2:11][CH2:12][OH:13]>CCN(CC)CC.C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[NH:6][C:7](=[S:8])[O:13][CH2:12][CH2:11][CH2:10][CH3:9]|US20040110788A1_0258
1.7.12|[C&H3&D1:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[C:3].[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[O&H0&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[C:3]|[CH2:1]=[CH:2][C:3](=[O:4])[OH:5].[CH3:6][CH:7]=[CH:8][CH:9]1[O:10][CH2:11][C:12]([CH2:13][O:14]1)([CH3:15])[CH3:16]>C=CC(=O)OCCC1OCC(CO1)(C)C>[CH2:1]=[CH:2][C:3](=[O:4])[O:5][CH:7]([CH3:6])[CH2:8][CH:9]1[O:10][CH2:11][C:12]([CH2:13][O:14]1)([CH3:15])[CH3:16]|US10550105B2_1694
2.3.2|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[S&H0&D1:3].[N&H2&+0&D1:2]-[N:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N:1])=[S&H0&D1:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[N:5]=[N:6][C:7]1([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1)[N:13]=[C:14]=[S:15].[CH3:16][C:17]([CH3:18])([CH3:19])[NH:20][NH2:21]>CCCCC>[CH3:16][C:17]([CH3:18])([CH3:19])[NH:20][NH:21][C:14](=[S:15])[NH:13][C:7]1([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12]1)[N:6]=[N:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20180162862A1_0409
3.5.2|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Br>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([n:11]1[CH3:12])[C:13](=[O:14])Cl.[CH3:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Mg]Br>c1ccccc1.CCOCC.Cl[Cd]Cl.Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([n:11]1[CH3:12])[C:13](=[O:14])[c:19]1[cH:18][cH:17][c:16]([cH:21][cH:20]1)[CH3:15]|US20130134350A1_0059
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH2:1][c:2]1[c:3]([cH:4][c:5]([cH:6][c:7]1[C:8](=[O:9])O)[Br:10])[Br:11].[CH3:12][NH:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>CCN(CC)CC.c1ccccc1.O=S(Cl)Cl>[CH3:12][N:13]([C:8](=[O:9])[c:7]1[cH:6][c:5]([cH:4][c:3]([c:2]1[NH2:1])[Br:11])[Br:10])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|EP1923062A1_0075
1.2.5|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[C:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][NH:2][CH3:3].O=[C:4]1[CH2:5][C:6]2=[C:7]([CH2:8][CH2:9]1)[c:10]1[cH:11][c:12]([cH:13][cH:14][c:15]1[O:16][c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]21)[Cl:23]>O.CN(C)C=O.O=CO>[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:9][CH2:8][C:7]2=[C:6]([CH2:5]1)[c:22]1[cH:21][cH:20][cH:19][cH:18][c:17]1[O:16][c:15]1[cH:14][cH:13][c:12]([cH:11][c:10]21)[Cl:23]|US20170008889A1_0198
7.6.1|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H3&D1:4])=[C&H0&+0&D3:3](-[C:2])-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:3](-[C:2])-[c:1]|[CH3:1][C:2]([CH3:3])=[C:4]1[C:5]([NH:6][c:7]2[cH:8][cH:9][c:10]([cH:11][c:12]12)[OH:13])=[O:14]>CCO.C1CCOC1.[H][H].[Pd]>[CH3:1][CH:2]([CH3:3])[CH:4]1[C:5]([NH:6][c:7]2[cH:8][cH:9][c:10]([cH:11][c:12]21)[OH:13])=[O:14]|US05536858A
2.3.1|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[N&H2&+0&D1:2]-[S:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[S:1])=[O&H0&D1:3]|[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[N:6]1[CH2:7][CH2:8][c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[CH2:15][CH2:16]1)[S:17]([NH2:18])(=[O:19])=[O:20].[O:21]=[C:22]=[N:23][CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1>O.Cl.CC(C)=O.O[Na]>[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[N:6]1[CH2:16][CH2:15][c:14]2[cH:13][cH:12][c:11]([cH:10][c:9]2[CH2:8][CH2:7]1)[S:17](=[O:19])(=[O:20])[NH:18][C:22](=[O:21])[NH:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1|EP2927214A1_0321
1.2.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][n:5][cH:6][cH:7][c:8]1-[c:9]1[cH:10][cH:11][c:12]2[n:13][c:14]([n:15][c:16]([c:17]2[cH:18]1)O)[CH:19]([NH2:20])[CH2:21][CH:22]([CH3:23])[CH3:24].[CH3:25][NH:26][CH3:27]>COc1cnccc1-c1ccc2nc(nc(c2c1)O)C(N)CC(C)C.COc1cccnc1B(O)O.O=C(O)C(F)(F)F>[CH3:1][O:2][c:3]1[cH:4][n:5][cH:6][cH:7][c:8]1-[c:9]1[cH:10][cH:11][c:12]2[n:13][c:14]([n:15][c:16]([c:17]2[cH:18]1)[N:26]([CH3:25])[CH3:27])[CH:19]([NH2:20])[CH2:21][CH:22]([CH3:23])[CH3:24]|US20120309739A1_0442
3.11.52|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-I.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:2](-[C:3])-[c:1]|[N:1]#[C:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[S:10][C:11]([F:12])([F:13])[F:14].[CH3:15][CH:16]([CH3:17])I>c1ccccc1.O[Na].O>[CH3:15][CH:16]([CH3:17])[CH:3]([C:2]#[N:1])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[S:10][C:11]([F:12])([F:13])[F:14]|US20200129627A1_2575
3.7.2|[C&H3&+0&D1:5]-[#12&+].[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[O&H1&+0&D1:1]|[Br-].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[n:9]1[n:10][c:11]([cH:12][c:13]1-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20])[CH2:21][CH2:22][C:23]([CH3:24])=[O:25].[CH3:26][Mg+]>C1CCOC1>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[n:9]1[n:10][c:11]([cH:12][c:13]1-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20])[CH2:21][CH2:22][C:23]([CH3:26])([CH3:24])[OH:25]|EP2978747B1_0250
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[N:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[N:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]1([C:6]([N:7]([C:8]([c:9]2[c:10]1[cH:11][cH:12][cH:13][cH:14]2)=[O:15])[CH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][c:22]1[F:23])[Br:24])=[O:25])[CH2:26][C:27](=[O:28])O.[CH3:29][NH:30][NH:31][CH3:32].Cl.Cl>CCN=C=NCCCN(C)C.On1nnc2c1cccc2.CCN(CC)CC.CN(C)C=O.O.O.Cl.Cl>[CH3:1][O:2][C:3](=[O:4])[C:5]1([C:6]([N:7]([C:8]([c:9]2[c:10]1[cH:11][cH:12][cH:13][cH:14]2)=[O:15])[CH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][c:22]1[F:23])[Br:24])=[O:25])[CH2:26][C:27](=[O:28])[N:31]([CH3:32])[NH:30][CH3:29]|US20190055283A1_0305
1.2.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][c:3]1[cH:4][c:5]([cH:6][c:7]([o:8]1)=[O:9])O.[CH3:10][NH:11][CH3:12]>Cc1ccc(cc1)S(=O)(=O)Cl.CCN(CC)CC.ClCCl>[CH3:1][CH2:2][c:3]1[cH:4][c:5]([cH:6][c:7]([o:8]1)=[O:9])[N:11]([CH3:10])[CH3:12]|US20170112785A1_0379
1.6.8|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-I.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH2:7][n:8]3[c:9]([cH:10][c:11]([nH:12][c:13]3=[O:14])=[O:15])-[c:16]2[cH:17][c:18]1[O:19][CH3:20].[CH3:21][CH:22]([CH3:23])I>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH2:7][n:8]3[c:9]([cH:10][c:11]([n:12]([c:13]3=[O:14])[CH:22]([CH3:21])[CH3:23])=[O:15])-[c:16]2[cH:17][c:18]1[O:19][CH3:20]|EP3608321A1_0123
2.3.2|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[S&H0&D1:3].[N&H2&+0&D1:2]-[S:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[S:1])=[S&H0&D1:3]|[F:1][C:2]([F:3])([F:4])[CH2:5][N:6]=[C:7]=[S:8].[CH3:9][S:10]([NH2:11])(=[O:12])=[O:13]>CC(C)=O.O[Na].O>[CH3:9][S:10](=[O:12])(=[O:13])[NH:11][C:7](=[S:8])[NH:6][CH2:5][C:2]([F:1])([F:3])[F:4]|US08586612B2_0080
2.1.2|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[O:1]=[S:2](=[O:3])([O:4][Na:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[NH:12][c:13]1[n:14][c:15]([n:16][c:17]([n:18]1)[NH:19][c:20]1[cH:21][cH:22][c:23]([c:24]([cH:25]1)[S:26](=[O:27])(=[O:28])[O:29][Na:30])[CH:31]=[CH:32][c:33]1[cH:34][cH:35][c:36]([cH:37][c:38]1[S:39](=[O:40])(=[O:41])[O:42][Na:43])[NH:44][c:45]1[n:46][c:47]([n:48][c:49]([n:50]1)[NH:51][c:52]1[cH:53][cH:54][c:55]([cH:56][cH:57]1)[S:58](=[O:59])(=[O:60])[O:61][Na:62])[N:63]([CH2:64][CH2:65][OH:66])[CH2:67][CH2:68][OH:69])[N:70]([CH2:71][CH2:72][OH:73])[CH2:74][CH2:75][OH:76].[CH3:77][C:78](=[O:79])O>ClCCCl.O.Cl>[CH3:77][C:78](=[O:79])[N:12]([c:13]1[n:14][c:15]([n:16][c:17]([n:18]1)[NH:19][c:20]1[cH:21][cH:22][c:23]([c:24]([cH:25]1)[S:26](=[O:27])(=[O:28])[O:29][Na:30])[CH:31]=[CH:32][c:33]1[cH:34][cH:35][c:36]([cH:37][c:38]1[S:39](=[O:40])(=[O:41])[O:42][Na:43])[NH:44][c:45]1[n:46][c:47]([n:48][c:49]([n:50]1)[NH:51][c:52]1[cH:53][cH:54][c:55]([cH:56][cH:57]1)[S:58](=[O:59])(=[O:60])[O:61][Na:62])[N:63]([CH2:64][CH2:65][OH:66])[CH2:67][CH2:68][OH:69])[N:70]([CH2:71][CH2:72][OH:73])[CH2:74][CH2:75][OH:76])[c:9]1[cH:8][cH:7][c:6]([cH:11][cH:10]1)[S:2](=[O:1])(=[O:3])[O:4][Na:5]|US20040158065A1_0146
2.1.2|[C:6]-[N&H1&+0&D2:5]-[N&H2&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:6]-[N&H0&+0&D3:5](-[N&H2&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](O)[c:3]1[cH:4][c:5]([c:6]([c:7]([c:8]1[NH:9][CH:10]1[CH2:11][CH2:12]1)[Cl:13])[F:14])[F:15].[CH3:16][C:17]([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[NH:23][NH2:24]>CCN=C=NCCCN(C)C.ClCCl>[CH3:16][C:17]([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]([NH2:24])[C:2](=[O:1])[c:3]1[cH:4][c:5]([c:6]([c:7]([c:8]1[NH:9][CH:10]1[CH2:11][CH2:12]1)[Cl:13])[F:14])[F:15]|US09585879B2_0248
2.1.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]-[N&H1&+0&D2:2]-[N&H2&D1:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[N&H2&D1:1]|[NH:1]=[C:2]([NH:3][NH2:4])[N:5]([NH2:6])[CH2:7][C:8](=[O:9])O>O.Cl>[NH:1]=[C:2]1[N:3]([C:8]([CH2:7][N:5]1[NH2:6])=[O:9])[NH2:4]|US10344023B2_0213
1.7.12|[C&H3&D1:6]-[O&H1&+0&D1:5].[O:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[O&H0&+0&D2:5]-[C&H1&+0&D3:3](-[O:4])-[C&H2&+0&D2:2]-[c:1]|[CH3:1][OH:2].[CH3:3][O:4][CH:5]=[CH:6][c:7]1[cH:8][cH:9][c:10]2[c:11]([cH:12]1)[c:13]([cH:14][n:15]2[CH2:16][CH2:17][CH3:18])[CH2:19][c:20]1[cH:21][cH:22][c:23]([cH:24][c:25]1[O:26][CH3:27])[C:28](=[O:29])[O:30][CH3:31]>O.Cc1ccc(cc1)S(=O)(=O)O.ClCCl>[CH3:1][O:2][CH:5]([CH2:6][c:7]1[cH:8][cH:9][c:10]2[c:11]([cH:12]1)[c:13]([cH:14][n:15]2[CH2:16][CH2:17][CH3:18])[CH2:19][c:20]1[cH:21][cH:22][c:23]([cH:24][c:25]1[O:26][CH3:27])[C:28](=[O:29])[O:30][CH3:31])[O:4][CH3:3]|US08871928B2_0593
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[N:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[N:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([n:6][c:7]([cH:8]1)[C:9](=[O:10])O)[O:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21].[CH3:22][NH:23][NH:24][CH3:25].Cl.Cl>CCN(CC)CC.CCOC(C)=O.c1ccccc1.CN(C)C=O.O=S(Cl)Cl>[CH3:22][NH:23][N:24]([CH3:25])[C:9](=[O:10])[c:7]1[cH:8][c:3]([cH:4][c:5]([n:6]1)[O:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21])[O:2][CH3:1]|US20200339559A1_0695
2.3.1|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[N&H2&+0&D1:2]-[c:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[CH2:14][CH2:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[NH2:22].[O:23]=[C:24]=[N:25][CH2:26][CH2:27][CH2:28][Cl:29]>Cc1ccccc1>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[CH2:14][CH2:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[NH:22][C:24](=[O:23])[NH:25][CH2:26][CH2:27][CH2:28][Cl:29]|US20200016159A1_0466
2.3.2|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[S&H0&D1:3].[C:2]-[N&H2&+0&D1:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[S&H0&D1:3]|[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1.[O:12]=[C:13]([N:14]=[C:15]=[S:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>ClC(Cl)Cl>[O:12]=[C:13]([NH:14][C:15](=[S:16])[NH:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|EP2961749B1_0507
1.1.6|[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:6]-[N&H0&+&D4:5](-[C&H3&D1:4])(-[C:3])-[C&H2&+0&D2:1]-[C:2]|[Cl-:1].[CH2:2]=[CH:3][CH2:4]Cl.[CH3:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:21]([CH3:22])[CH3:23]>F[Ag]>[Cl-:1].[CH2:2]=[CH:3][CH2:4][N+:21]([CH3:22])([CH3:23])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH3:5]|US04853138A
1.6.8|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-I.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[NH:19][S:20](=[O:21])(=[O:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[Cl:29].[CH3:30][CH:31]([CH3:32])I>O.Cl.CN(C)C=O.O=C(O[K])O[K]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:10][cH:9][c:8]([cH:7][cH:6]1)[CH2:11][O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[N:19]([CH:31]([CH3:30])[CH3:32])[S:20](=[O:21])(=[O:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[Cl:29]|US20040023938A1_0611
7.6.1|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:3](-[C&H3&D1:2])-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:3](-[C&H3&D1:2])-[C:1]|[CH3:1][C:2]1[CH2:3][c:4]2[c:5]([CH2:6][C:7]=1[CH3:8])[c:9]([nH:10][c:11]2-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>[NH4+].CCO.[O-]C=O.[Pd]>[CH3:1][CH:2]1[CH2:3][c:4]2[c:11]([nH:10][c:9]([c:5]2[CH2:6][CH:7]1[CH3:8])-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US20160318866A1_0924
1.8.17|[C&H3&D1:6]-[S&H1&+0&D1:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[S&H0&+0&D2:5]-[C&H1&+0&D3:2](-[C:1])-[C&H2&+0&D2:3]-[C:4]|[CH3:1][NH:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][CH:8]([CH2:9][CH2:10]1)[CH2:11][C:12](=[O:13])[N:14]1[C:15]([CH:16]=[CH:17][C:18]1=[O:19])=[O:20].[CH3:21][SH:22]>>[CH3:1][NH:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][CH:8]([CH2:9][CH2:10]1)[CH2:11][C:12](=[O:13])[N:14]1[C:15]([CH2:16][CH:17]([C:18]1=[O:19])[S:22][CH3:21])=[O:20]|
2.1.2|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2](=[O:3])O.[O:4]=[C:5]1[CH2:6][CH2:7][NH:8][C:9]([NH:10]1)=[O:11]>CC(=O)OC(C)=O.O=S(=O)(O)O>[CH3:1][C:2](=[O:3])[N:8]1[CH2:7][CH2:6][C:5]([NH:10][C:9]1=[O:11])=[O:4]|EP3057950B1_0102
1.6.8|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-I.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH:2]([CH3:3])I.[CH3:4][C:5]1([CH2:6][C:7]([NH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21)=[O:15])[CH3:16]>[Na+].CN(C)C=O.[H-]>[CH3:4][C:5]1([CH2:6][C:7]([N:8]([c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21)[CH:2]([CH3:1])[CH3:3])=[O:15])[CH3:16]|EP3140304B1_0152
1.8.17|[C&H3&D1:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[C:3].[C:2]-[S&H1&+0&D1:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[S&H0&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[C:3]|[CH3:1][CH:2]=[CH:3][C:4]([CH3:5])=[O:6].[SH:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][o:13]1>CCO>[CH3:5][C:4](=[O:6])[CH2:3][CH:2]([CH3:1])[S:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][o:13]1|EP3533786A1_0053
1.3.8|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][NH:2][CH3:3].[O:4]=[C:5]([CH2:6][CH2:7][CH2:8][N:9]1[CH2:10][CH2:11][CH:12]([CH2:13][CH2:14]1)[C:15]([OH:16])([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)F>CS(C)=O>[CH3:1][N:2]([CH3:3])[c:32]1[cH:31][cH:30][c:29]([cH:34][cH:33]1)[C:5](=[O:4])[CH2:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([CH2:11][CH2:10]1)[C:15]([OH:16])([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|US20200369665A1_1097
2.3.2|[C:6]-[N&H2&+0&D1:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|Cl.[CH3:1][CH2:2][CH2:3][CH2:4][C:5](=[NH:6])[NH2:7].[S:8]=[C:9]=[N:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]>CC(C)=O.[Na]>[CH3:1][CH2:2][CH2:3][CH2:4][C:5](=[NH:6])[NH:7][C:9](=[S:8])[NH:10][c:11]1[cH:16][cH:15][c:14]([cH:13][cH:12]1)[Cl:17]|US09656991B2_0438
3.11.91|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C:3].[C:2]-[C&H2&+0&D2:1]-I>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH:2]([CH3:3])[C:4](=[O:5])[OH:6].[CH3:7][CH2:8][CH2:9]I>CC(C)NC(C)C.CCCCC.CC(C)(C)[Li].C1CCOC1.Cl>[CH3:7][CH2:8][CH2:9][C:2]([CH3:1])([CH3:3])[C:4](=[O:5])[OH:6]|US20200062711A1_0330
2.1.2|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][C:2](=[O:3])O.[CH3:4][CH:5]([CH3:6])[NH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[OH:14]>CC(=O)OC(C)=O.O=C(O[Na])O[Na].O[Na]>[CH3:1][C:2](=[O:3])[N:7]([c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[OH:14])[CH:5]([CH3:4])[CH3:6]|US20200207764A1_1293
3.11.91|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH3:6])[CH3:7].[CH3:8][C:9]([CH3:10])=[CH:11][CH2:12]Br>CC(C)N(C(C)C)[Li].CCCCCC.C1CCOC1.CS(C)=O.Cl[Na]>[CH3:8][C:9]([CH3:10])=[CH:11][CH2:12][C:5]([CH3:6])([CH3:7])[C:3](=[O:4])[O:2][CH3:1]|US20200385384A1_0769
3.7.2|[C&H3&+0&D1:5]-[#12]-Br.[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][C:2]1=[CH:3][CH2:4][CH2:5][CH:6]([CH2:7]1)[C:8]([CH3:9])=[O:10].[CH3:11][Mg]Br>CCOCC.C1CCOC1>[CH3:1][C:2]1=[CH:3][CH2:4][CH2:5][CH:6]([CH2:7]1)[C:8]([CH3:11])([CH3:9])[OH:10]|US20200261411A1_1124
3.11.52|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-Br.[C:3]-[C&H2&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:2](-[C:3])-[c:1]|[N:1]#[C:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][C:11]([F:12])([F:13])[CH:14]([F:15])[F:16].[CH3:17][CH:18]([CH3:19])Br>C1CCC2OCCOCCOC3CCCCC3OCCOCCOC2C1.c1ccccc1.O[Na]>[CH3:17][CH:18]([CH3:19])[CH:3]([C:2]#[N:1])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][C:11]([F:12])([F:13])[CH:14]([F:15])[F:16]|US20200230097A1_0337
3.11.93|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][CH:3]1[CH2:4][C:5]([CH2:6][CH2:7][CH2:8]1)=[O:9].[CH3:10][C:11](=[O:12])Cl>c1ccccc1.CCNCC.C1CCNC1.O>[CH3:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([C:5]([CH2:4]1)=[O:9])[C:11]([CH3:10])=[O:12]|US05354767A
3.7.3|[C:6]-[C&H0&+0&D3:5](-[C:4])=[O&H0&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-[#12]-Cl>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[O&H1&+0&D1:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[Cl:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[CH2:22][Mg]Cl>[NH4+].[Cl-].CCOCC>[OH:1][C:2]1([CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[CH2:22][c:19]1[cH:18][cH:17][c:16]([cH:21][cH:20]1)[Cl:15]|US20090270381A1_0201
3.7.2|[C:6]-[C&H0&+0&D3:5](-[C:4])=[O&H0&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-[#12]-Br>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[O&H1&+0&D1:3])-[C&H2&+0&D2:1]-[c:2]|[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH2:8][CH2:9][C:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][n:28]1.Br[Mg][CH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>CCOCC>[OH:1][C:2]1([CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH2:8][CH2:9][C:10]([c:23]1[cH:24][cH:25][cH:26][cH:27][n:28]1)([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[CH2:29][c:30]1[cH:35][cH:34][cH:33][cH:32][cH:31]1|US20080182851A1_0328
3.7.3|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Cl>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][P:4](=[O:5])([O:6][CH2:7][CH3:8])[c:9]1[cH:10][c:11]([cH:12][c:13]2[cH:14][cH:15][c:16]([n:17][c:18]12)[CH:19]=[O:20])-[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[CH2:27][O:28][CH:29]1[CH2:30][CH2:31][CH2:32][CH2:33][O:34]1.Cl[Mg][c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1>[NH4+].[Cl-].C1CCOC1>[CH3:1][CH2:2][O:3][P:4](=[O:5])([O:6][CH2:7][CH3:8])[c:9]1[cH:10][c:11]([cH:12][c:13]2[cH:14][cH:15][c:16]([n:17][c:18]12)[CH:19]([OH:20])[c:35]1[cH:40][cH:39][cH:38][cH:37][cH:36]1)-[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[CH2:27][O:28][CH:29]1[CH2:30][CH2:31][CH2:32][CH2:33][O:34]1|US20060074102A1_0793
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-Br.[C&H3&D1:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C&H3&D1:3])-[c:1]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[F:9])[F:10].[CH3:11][N:12]([CH3:13])[CH2:14][CH2:15][NH:16][C:17](=[O:18])[c:19]1[cH:20][c:21]2[c:22]([cH:23][c:24]([o:25][c:26]2[c:27]([cH:28]1)[CH:29]([CH3:30])Br)[N:31]1[CH2:32][CH2:33][O:34][CH2:35][CH2:36]1)=[O:37]>Br>[CH3:30][CH:29]([c:27]1[cH:28][c:19]([cH:20][c:21]2[c:26]1[o:25][c:24]([cH:23][c:22]2=[O:37])[N:31]1[CH2:32][CH2:33][O:34][CH2:35][CH2:36]1)[C:17](=[O:18])[NH:16][CH2:15][CH2:14][N:12]([CH3:11])[CH3:13])[N:2]([CH3:1])[c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[F:9])[F:10]|US08871754B2_0408
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[N&H2&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[N&H2&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][c:9]([c:10]([c:11]1[Cl:12])[N+:13]([O-:14])=[O:15])Cl)[CH3:16].[CH3:17][NH:18][NH2:19]>CO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][c:9]([c:10]([c:11]1[Cl:12])[N+:13]([O-:14])=[O:15])[N:18]([CH3:17])[NH2:19])[CH3:16]|EP3632908A1_0239
2.3.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][N:2]([CH3:3])[C:4](=[O:5])Cl.[CH3:6][NH:7][c:8]1[n:9][c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[s:16]1)[Cl:17]>O.CN(C)C=O.[NaH]>[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[N:7]([CH3:6])[c:8]1[n:9][c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[s:16]1)[Cl:17]|US09809574B2_0782
3.7.2|[C:6]#[C&H0&+0&D2:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C:6]#[C&H0&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[C:5](=[O:6])[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.[CH3:13][C:14]#[C:15][Mg]Br>Cl.C#CC.CCBr.CCOCC.C1CCOC1.[Mg]>[CH3:13][C:14]#[C:15][C:5]([OH:6])([C:3](=[O:4])[O:2][CH3:1])[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1|US20070066628A1_0177
3.10.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])Cl.[F:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>Cl.S=C=S.Cl[Al](Cl)Cl>[CH3:1][C:2](=[O:3])[c:14]1[cH:15][cH:16][c:11]([cH:12][cH:13]1)-[c:10]1[cH:9][cH:8][cH:7][cH:6][c:5]1[F:4]|EP2193692B1_0039
2.4.5|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][s:9][c:10]([n:11]1)[NH:12][CH3:13].[CH3:14][CH2:15][C:16]([CH3:17])([CH3:18])[O:19][C:20](=[O:21])Cl>O.ClCCl.c1ccncc1>[CH3:14][CH2:15][C:16]([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[N:12]([CH3:13])[c:10]1[n:11][c:7]([cH:8][s:9]1)[CH2:6][C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20170290337A1_0158
2.1.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[NH:14][CH2:15][c:16]1[cH:17][cH:18][c:19]2[O:20][CH2:21][O:22][c:23]2[cH:24]1.[CH3:25][C:26](=[O:27])Cl>CC(C)N(CC)C(C)C.c1ccccc1>[CH3:25][C:26](=[O:27])[N:14]([CH2:15][c:16]1[cH:17][cH:18][c:19]2[O:20][CH2:21][O:22][c:23]2[cH:24]1)[c:11]1[cH:10][cH:9][c:8]([cH:13][cH:12]1)[O:7][c:4]1[cH:3][cH:2][cH:1][cH:6][cH:5]1|EP3071562B1_0215
2.1.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2](=[O:3])Cl.[O:4]=[C:5]1[NH:6][CH2:7][CH2:8][CH2:9][NH:10]1>ClC(Cl)Cl.c1ccncc1.C1CCOC1>[CH3:1][C:2](=[O:3])[N:10]1[CH2:9][CH2:8][CH2:7][NH:6][C:5]1=[O:4]|EP3328859B1_0676
2.1.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][S:2][c:3]1[n:4][c:5]([n:6]([c:7]([nH:8]1)=[O:9])[CH:10]([CH3:11])[CH3:12])=[O:13].[CH3:14][C:15](=[O:16])Cl.[Na]>C1CCOC1>[CH3:1][S:2][c:3]1[n:4][c:5]([n:6]([c:7]([n:8]1[C:15]([CH3:14])=[O:16])=[O:9])[CH:10]([CH3:11])[CH3:12])=[O:13]|EP2961747B1_0366
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][CH3:20].[CH3:21][c:22]1[cH:23][c:24]([c:25]([c:26]([c:27]1[CH2:28][C:29](=[O:30])Cl)[CH3:31])[OH:32])[C:33]([CH3:34])([CH3:35])[CH3:36]>c1ccccc1>[CH3:34][C:33]([CH3:35])([CH3:36])[c:24]1[cH:23][c:22]([c:27]([c:26]([c:25]1[OH:32])[CH3:31])[CH2:28][C:29](=[O:30])[N:19]([CH3:20])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH3:1])[CH3:21]|US20200131669A1_1890
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH:1]#[C:2][CH2:3][NH:4][CH3:5].[O:6]=[C:7](Br)[CH2:8][Br:9]>CCOCC.O=C(O)O[Na].ClCCl>[CH:1]#[C:2][CH2:3][N:4]([CH3:5])[C:7](=[O:6])[CH2:8][Br:9]|US20100144727A1_0204
3.7.3|[C&H3&+0&D1:5]-[#12]-Cl.[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[F:10])[C:11]#[N:12].[CH3:13][Mg]Cl>Cl[Ce](Cl)Cl.C1CCOC1>[CH3:13][C:2]([CH3:1])([OH:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[F:10])[C:11]#[N:12]|US20200255426A1_0622
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][NH:2][c:3]1[n:4][c:5]([cH:6][s:7]1)[CH2:8][C:9](=[O:10])[NH:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21].[CH3:22][CH:23]([CH3:24])[C:25](=[O:26])Cl>c1ccncc1.O>[CH3:22][CH:23]([CH3:24])[C:25](=[O:26])[N:2]([CH3:1])[c:3]1[n:4][c:5]([cH:6][s:7]1)[CH2:8][C:9](=[O:10])[NH:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18]([F:19])([F:20])[F:21]|EP3356343B1_0208
3.7.2|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c:3].[c:2]-[C&H2&+0&D2:1]-[#12]-Br>>[C:6]-[C&H0&+0&D4:5](-[O&H1&+0&D1:4])(-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[CH2:9][Mg]Br.[O:10]=[C:11]([c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[F:18])[CH:19]1[CH2:20][N:21]([CH2:22][CH2:23][O:24]1)[CH2:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>[Na+].[O-]C(=O)O.C1CCOC1>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[CH2:9][C:11]([OH:10])([c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[F:18])[CH:19]1[CH2:20][N:21]([CH2:22][CH2:23][O:24]1)[CH2:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1|US20200039973A1_0576
3.10.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2](=[O:3])Cl.[cH:4]1[cH:5][cH:6][n:7]([cH:8]1)[CH2:9][c:10]1[cH:11][cH:12][cH:13][o:14]1>>[CH3:1][C:2](=[O:3])[c:8]1[cH:4][cH:5][cH:6][n:7]1[CH2:9][c:10]1[cH:11][cH:12][cH:13][o:14]1|EP2649064B1_0145
1.6.4|[F&H0&D1:6]-[C&H1&+0&D3:5](-[F&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[F&H0&D1:6]-[C&H1&+0&D3:5](-[F&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[Cl:9])[F:10])-[n:11]1[n:12][c:13]([nH:14][c:15]1=[O:16])[CH3:17].[F:18][CH:19]([F:20])Cl>CCCC[N+](CCCC)(CCCC)CCCC.C1CCCCC1.O[Na].[Br-]>[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[Cl:9])[F:10])-[n:11]1[n:12][c:13]([n:14]([c:15]1=[O:16])[CH:19]([F:18])[F:20])[CH3:17]|US09914735B2_0265
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][n:2]1[c:3]([n:4][cH:5][c:6]1-[c:7]1[n:8][n:9][c:10]2[cH:11][cH:12][c:13]([n:14][n:15]12)Cl)[N+:16]([O-:17])=[O:18].[CH3:19][NH:20][CH3:21]>CN(C)C=O>[CH3:19][N:20]([CH3:21])[c:13]1[cH:12][cH:11][c:10]2[n:9][n:8][c:7]([n:15]2[n:14]1)-[c:6]1[cH:5][n:4][c:3]([n:2]1[CH3:1])[N+:16]([O-:17])=[O:18]|EP2785714B1_0250
3.7.3|[C:6]-[C&H2&+0&D2:5]-[#12]-Cl.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][N:2]([CH2:3][C@H:4]([CH2:5][CH:6]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)[NH:12][C:13](=[O:14])[CH:15]1[CH2:16][CH2:17][CH2:18][CH:19]([CH2:20]1)[C:21](=[O:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:29](=[O:30])[O:31][CH2:32][CH2:33][Si:34]([CH3:35])([CH3:36])[CH3:37].[CH3:38][O:39][CH2:40][CH2:41][CH2:42][CH2:43][Mg]Cl>>[CH3:35][Si:34]([CH3:36])([CH3:37])[CH2:33][CH2:32][O:31][C:29](=[O:30])[N:2]([CH3:1])[CH2:3][C@H:4]([CH2:5][CH:6]1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)[NH:12][C:13](=[O:14])[CH:15]1[CH2:16][CH2:17][CH2:18][CH:19]([CH2:20]1)[C:21]([OH:22])([CH2:43][CH2:42][CH2:41][CH2:40][O:39][CH3:38])[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|US20090264428A1_0456
3.7.2|[C:6]-[C&H2&+0&D2:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([CH3:8])([CH3:9])[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH:24]1[CH2:25][N:26]([CH2:27][CH2:28][C:29]1=[O:30])[CH2:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.Br[Mg][CH2:38][CH2:39][CH2:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1>[NH4+].[Cl-].CCOCC.C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([CH3:8])([CH3:9])[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH:24]1[CH2:25][N:26]([CH2:27][CH2:28][C:29]1([OH:30])[CH2:38][CH2:39][CH2:40][c:41]1[cH:46][cH:45][cH:44][cH:43][cH:42]1)[CH2:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1|US09290517B2_0751
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH:2]([CH3:3])Br.[O-:4][N+:5](=[O:6])[c:7]1[cH:8][cH:9][c:10]([o:11]1)-[c:12]1[n:13][nH:14][cH:15][c:16]1[CH:17]=[O:18]>O.CC(=O)O.CN(C)C=O.[NaH]>[CH3:1][CH:2]([CH3:3])[n:14]1[cH:15][c:16]([c:12]([n:13]1)-[c:10]1[cH:9][cH:8][c:7]([o:11]1)[N+:5]([O-:4])=[O:6])[CH:17]=[O:18]|US20200317643A1_0850
3.11.91|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH:2]([CH3:3])[C:4](=[O:5])[CH:6]([CH3:7])[CH3:8].[CH2:9]=[C:10]([CH3:11])[CH:12]=[CH:13][CH2:14]Cl>>[CH2:9]=[C:10]([CH3:11])[CH:12]=[CH:13][CH2:14][C:6]([CH3:7])([CH3:8])[C:4](=[O:5])[CH:2]([CH3:1])[CH3:3]|US20200048242A1_0308
2.4.5|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])Cl.[CH3:6][NH:7][CH:8]1[CH2:9][CH2:10][c:11]2[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[nH:18][c:19]2[CH2:20]1>[Na+].[O-]C(=O)O.ClCCl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:7]([CH3:6])[CH:8]1[CH2:9][CH2:10][c:11]2[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[nH:18][c:19]2[CH2:20]1|US20200331850A1_0880
1.3.6|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][NH:2][CH3:3].Br[c:4]1[n:5][cH:6][cH:7][s:8]1>>[CH3:1][N:2]([CH3:3])[c:4]1[n:5][cH:6][cH:7][s:8]1|US20180118718A1_1075
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][n:3]1[c:4]([n:5][c:6]2[cH:7][c:8]([c:9]([c:10]([c:11]21)[N+:12]([O-:13])=[O:14])Cl)[C:15]([F:16])([F:17])[F:18])[CH3:19].[CH3:20][NH:21][CH3:22]>COCCOC>[CH3:19][c:4]1[n:5][c:6]2[cH:7][c:8]([c:9]([c:10]([c:11]2[n:3]1[CH2:2][CH3:1])[N+:12]([O-:13])=[O:14])[N:21]([CH3:20])[CH3:22])[C:15]([F:16])([F:17])[F:18]|EP3643711A1_0318
3.7.3|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Cl>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]1[NH:3][C:4]([S:5][C:6]1=[C:7]([CH:8]=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)=[O:16].Cl[Mg][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>C1CCOC1>[O:16]=[C:4]1[NH:3][C:2]([C:6]([S:5]1)=[C:7]([c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1)[CH:8]([OH:9])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:1]|US20190300537A1_0600
3.7.2|[C:6]#[C&H0&+0&D2:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C:6]#[C&H0&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][N:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[CH2:10][C:11]2([C:12]([CH2:13][CH2:14][CH:15]2[CH:16]2[CH2:17][CH2:18][C:19]3([CH2:20][C:21]4([CH2:22][CH2:23][C:24]3=[C:25]12)[O:26][CH2:27][CH2:28][O:29]4)[OH:30])=[O:31])[CH3:32])[CH:33]1[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]1.Br[Mg][C:39]#[C:40][CH2:41][O:42][CH:43]1[CH2:44][CH2:45][CH2:46][CH2:47][O:48]1>>[CH3:1][N:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[CH2:10][C:11]2([CH:15]([CH2:14][CH2:13][C:12]2([OH:31])[C:39]#[C:40][CH2:41][O:42][CH:43]2[CH2:44][CH2:45][CH2:46][CH2:47][O:48]2)[CH:16]2[CH2:17][CH2:18][C:19]3([CH2:20][C:21]4([CH2:22][CH2:23][C:24]3=[C:25]12)[O:26][CH2:27][CH2:28][O:29]4)[OH:30])[CH3:32])[CH:33]1[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]1|US20190389899A1_0353
2.1.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[S:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[S:3])-[c:1]|[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[CH3:13])[NH:14][S:15](=[O:16])(=[O:17])[C:18]([F:19])([F:20])[F:21].[CH3:22][C:23](=[O:24])Cl>CCN(CC)CC.C1CCOC1>[CH3:22][C:23](=[O:24])[N:14]([c:10]1[cH:9][cH:8][c:7]([cH:12][c:11]1[CH3:13])[S:4](=[O:5])(=[O:6])[N:2]([CH3:1])[CH3:3])[S:15](=[O:16])(=[O:17])[C:18]([F:19])([F:20])[F:21]|US09399639B2_0282
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH2:2][CH:3]([CH3:4])[NH:5][c:6]1[n:7][c:8]([n:9][c:10]([c:11]1[N+:12]([O-:13])=[O:14])[CH3:15])Cl.[CH3:16][NH:17][CH3:18]>CCN(CC)CC>[CH3:1][CH2:2][CH:3]([CH3:4])[NH:5][c:6]1[n:7][c:8]([n:9][c:10]([c:11]1[N+:12]([O-:13])=[O:14])[CH3:15])[N:17]([CH3:16])[CH3:18]|EP3259254B1_0156
3.7.3|[C&H3&+0&D1:5]-[#12]-Cl.[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][C:2](=[O:3])[C:4]1=[CH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1.[CH3:16][Mg]Cl>O.C1CCOC1>[CH3:16][C:2]([CH3:1])([OH:3])[C:4]1=[CH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1|US20190151403A1_0567
1.3.6|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][NH:2][CH3:3].[O:4]=[C:5]1[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[CH2:12][CH2:13][c:14]2[c:15]1[n:16][c:17]1[c:18]([cH:19][n:20][n:21]1[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[c:29]2Br>CN>[CH3:1][N:2]([CH3:3])[c:29]1[c:18]2[cH:19][n:20][n:21]([c:17]2[n:16][c:15]2[C:5]([c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[CH2:12][CH2:13][c:14]21)=[O:4])[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|EP3242872B1_0440
3.11.91|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[C&H2&+0&D2:1]-[c:2]|Cl[CH2:1][c:2]1[cH:3][cH:4][cH:5][s:6]1.[CH3:7][CH:8]([CH3:9])[C:10](=[O:11])[OH:12]>CC(C)NC(C)C.CCCCCC.CCCC[Li].C1CCOC1.O.[NaH]>[CH3:7][C:8]([CH3:9])([CH2:1][c:2]1[cH:3][cH:4][cH:5][s:6]1)[C:10](=[O:11])[OH:12]|US20200316080A1_1172
3.7.2|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Br>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[CH:4]=[O:5].[Br:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[Mg]Br>CCOCC>[CH3:1][CH:2]([CH3:3])[CH:4]([OH:5])[c:10]1[cH:11][cH:12][c:7]([cH:8][cH:9]1)[Br:6]|US20080318947A1_0600
2.1.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2](=[O:3])Cl.[CH3:4][O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][c:14]([n:15][nH:16]1)-[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[C:23](=[O:24])[O:25][CH3:26]>C1CCOC1.[NaH]>[CH3:4][O:5][c:6]1[cH:11][cH:10][c:9]([cH:8][cH:7]1)-[c:12]1[cH:13][c:14]([n:15][n:16]1[C:2]([CH3:1])=[O:3])-[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[C:23](=[O:24])[O:25][CH3:26]|US20140357662A1_0484
3.7.2|[C:6]-[C&H2&+0&D2:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH2:1]=[CH:2][CH2:3][Mg]Br.[O:4]=[C:5]([CH2:6][CH2:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[O:22][CH2:23][c:24]1[cH:25][cH:26][c:27]2[cH:28][cH:29][cH:30][cH:31][c:32]2[n:33]1>[NH4+].[Cl-].C1CCOC1>[CH2:1]=[CH:2][CH2:3][C:5]([OH:4])([CH2:6][CH2:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15])[c:16]1[cH:21][cH:20][c:19]([cH:18][cH:17]1)[O:22][CH2:23][c:24]1[cH:25][cH:26][c:27]2[cH:28][cH:29][cH:30][cH:31][c:32]2[n:33]1|US20070105820A1_0570
1.3.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:7])[c:8]1[cH:9][s:10][c:11]([n:12]1)Cl.[CH3:13][NH:14][CH3:15]>c1ccccc1.C1CCOC1.O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:7])[c:8]1[cH:9][s:10][c:11]([n:12]1)[N:14]([CH3:13])[CH3:15]|US20080139558A1_0519
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][NH:2][CH:3]1[CH2:4][CH2:5][N:6]([CH2:7]1)[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1.[O-:14][N+:15](=[O:16])[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[C:23](=[O:24])Cl>O=C(O)/C=C/C(=O)O.CC(C)OC(C)C.CC(C)O>[CH3:1][N:2]([C:23](=[O:24])[c:20]1[cH:19][cH:18][c:17]([cH:22][cH:21]1)[N+:15]([O-:14])=[O:16])[CH:3]1[CH2:7][N:6]([CH2:5][CH2:4]1)[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1|US20200329707A1_0056
3.7.2|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Br>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[Br:8])[CH:9]=[O:10].Br[Mg][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>COc1ccc(cc1)C(O)c1ccccc1Br>[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[Br:8])[CH:9]([OH:10])[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US20200199131A1_0891
3.7.3|[C:6]-[C&H1&+0&D3:5](-[C:4])-[#12]-Cl.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][Si:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][o:9]1)[CH:10]=[O:11].Cl[Mg][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1>O=S(=O)(O)O.C1CCOC1.O>[CH3:1][Si:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][o:9]1)[CH:10]([OH:11])[CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1|US20160145247A1_1305
3.7.2|[C:6]-[C&H1&+0&D3:5](-[C:4])-[#12]-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]=[O:10].Br[Mg][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]([OH:10])[CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1|US20200216467A1_0543
4.1.42|[C&H3&D1:6]-[C&H0&+0&D2:5]#[C&H0&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[c&H0&+0&D3:5]1:[n&H1&+0&D2:1]:[c:2]:[c:3]:[c&H1&+0&D2:4]:1|[CH3:1][C:2]#[C:3][c:4]1[cH:5][c:6]([cH:7][c:8]([c:9]1[NH2:10])[C:11](=[O:12])[O:13][CH3:14])[Cl:15]>O.CC(=O)OCC.CN1CCCC1=O.CC(C)(C)[O-].[K+]>[CH3:14][O:13][C:11](=[O:12])[c:8]1[cH:7][c:6]([cH:5][c:4]2[cH:3][c:2]([nH:10][c:9]12)[CH3:1])[Cl:15]|US20200308198A1_0328
2.1.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[F:1][c:2]1[cH:3][cH:4][c:5]2[NH:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[S:13][c:14]2[cH:15]1.[CH3:16][C:17](=[O:18])Cl>c1ccccc1>[CH3:16][C:17](=[O:18])[N:6]1[c:5]2[cH:4][cH:3][c:2]([cH:15][c:14]2[S:13][c:12]2[cH:11][cH:10][cH:9][cH:8][c:7]21)[F:1]|US20130053375A1_0594
1.9.7|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5](Cl)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13].I[c:14]1[cH:15][n:16][nH:17][cH:18]1>CC(C)(C)[Li].C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[c:14]1[cH:15][n:16][nH:17][cH:18]1|US20040157892A1_0089
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[N:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[N:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([O:4][N:5]1[C:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[C:13]1=[O:14])=[O:15])[C:16](=[O:17])Cl.[CH3:18][NH:19][NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27]>CN(C)c1ccncc1.CCN(CC)CC.C1CCOC1>[CH3:18][N:19]([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[C:16](=[O:17])[C:2]([CH3:1])([CH3:3])[O:4][N:5]1[C:6]([c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[C:13]1=[O:14])=[O:15]|US20120028988A1_0555
1.2.17|[C:7]-[C&H0&+0&D2:6]#[C&H0&+0&D2:5]-[c:4]:[c:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c:4]:[c:3]:[n&H0&+0&D3:2]:1-[C:1]|[CH3:1][CH2:2][CH2:3][C:4]#[C:5][c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1[NH:12][C:13](=[O:14])[O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[C:23](=[O:24])[O:25][CH3:26]>C1CCOC1>[CH3:26][O:25][C:23](=[O:24])[c:9]1[cH:8][cH:7][c:6]2[cH:5][c:4]([n:12]([c:11]2[cH:10]1)[C:13](=[O:14])[O:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[CH2:3][CH2:2][CH3:1]|EP1592426B1_0242
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|Cl.[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[S:14](=[O:15])(=[O:16])[N:17]([CH3:18])[CH3:19])[C:20](=[O:21])Cl.[CH3:22][NH:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>Cl.C1CCOC1>[CH3:22][N:23]([C:20](=[O:21])[c:11]1[cH:10][cH:9][c:8]([c:13]([cH:12]1)[S:14](=[O:15])(=[O:16])[N:17]([CH3:18])[CH3:19])[N:5]1[CH2:6][CH2:7][N:2]([CH2:3][CH2:4]1)[CH3:1])[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1|US20140057953A1_0248
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])Br.[O:4]=[c:5]1[cH:6][cH:7][s:8][c:9]2[c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[nH:16][c:17]12>>[CH3:1][CH:2]([CH3:3])[n:16]1[c:17]2[c:9]([s:8][cH:7][cH:6][c:5]2=[O:4])[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21|EP3733676A1_0174
2.1.1|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[O&H1&D1:1]>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[O&H1&D1:1]|[O:1]=[P:2]([OH:3])([OH:4])[CH2:5][CH2:6][CH2:7][NH:8][OH:9].[O:10]=[C:11]([NH:12][CH2:13][C:14](=[O:15])Cl)[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>O.CO.CCOCC.O=C(O)O[Na].O[Na]>[O:1]=[P:2]([OH:3])([OH:4])[CH2:5][CH2:6][CH2:7][N:8]([OH:9])[C:14](=[O:15])[CH2:13][NH:12][C:11](=[O:10])[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20130210625A1_0271
3.10.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][C:2](=[O:3])Cl.[Cl:4][C:5]([Cl:6])=[CH:7][c:8]1[cH:9][cH:10][cH:11][s:12]1>O.CCCCCCC.Cc1ccccc1.CCOC(C)=O.ClCCl.Cl[Al](Cl)Cl>[CH3:1][C:2](=[O:3])[c:11]1[cH:10][cH:9][c:8]([s:12]1)[CH:7]=[C:5]([Cl:4])[Cl:6]|EP2848617A1_0263
3.11.91|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH2:11]Br.[CH3:12][CH:13]([CH3:14])[C:15](=[O:16])[OH:17]>CN(C)P(=O)(N(C)C)N(C)C.CC(C)NC(C)C.CCCCCC.C1CCOC1.[CH2]CCC.[Li]>[CH3:10][O:9][c:8]1[cH:7][cH:6][c:5]([cH:4][c:3]1[O:2][CH3:1])[CH2:11][C:13]([CH3:12])([CH3:14])[C:15](=[O:16])[OH:17]|US10364256B2_0562
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[O:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[O:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](Cl)[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[S:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH3:16][O:17][NH:18][CH3:19]>CCN(CC)CC.C1CCOC1>[CH3:16][O:17][N:18]([CH3:19])[C:2](=[O:1])[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[S:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|EP3087060B1_0188
1.9.7|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|I[c:1]1[cH:2][n:3]([cH:4][n:5]1)[C:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[CH3:25][CH2:26][CH2:27][CH2:28][Sn:29](Cl)([CH2:30][CH2:31][CH2:32][CH3:33])[CH2:34][CH2:35][CH2:36][CH3:37]>CC[Mg]Br.ClCCl>[CH3:25][CH2:26][CH2:27][CH2:28][Sn:29]([CH2:30][CH2:31][CH2:32][CH3:33])([CH2:34][CH2:35][CH2:36][CH3:37])[c:1]1[cH:2][n:3]([cH:4][n:5]1)[C:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1|EP2001849B1_0324
1.6.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][CH2:3][C:4]1([CH2:5][CH2:6][NH:7][CH2:8][CH2:9]1)[NH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[CH3:17][CH:18]([CH3:19])Br>CCN(CC)CC.CN(C)C(C)=O>[CH3:1][O:2][CH2:3][C:4]1([CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[CH:18]([CH3:17])[CH3:19])[NH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US20200361895A1_0546
3.7.3|[C:6]-[C&H0&+0&D3:5](-[C:4])=[O&H0&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-[#12]-Cl>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[O&H1&+0&D1:3])-[C&H2&+0&D2:1]-[C:2]|[O:1]=[C:2]([C:3]([F:4])([F:5])[F:6])[C:7]([F:8])([F:9])[C:10]([F:11])([Cl:12])[C:13]([F:14])([F:15])[Cl:16].[CH2:17]=[CH:18][CH2:19][Mg]Cl>CCOCC.C1CCOC1.O.Cl>[CH2:17]=[CH:18][CH2:19][C:2]([OH:1])([C:3]([F:4])([F:5])[F:6])[C:7]([F:8])([F:9])[C:10]([F:11])([Cl:12])[C:13]([F:14])([F:15])[Cl:16]|US20190218187A1_0552
3.7.2|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-[#12]-Br>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][N:7]1[C:8]([CH2:9][N:10]([S:11]1(=[O:12])=[O:13])[c:14]1[cH:15][cH:16][c:17]([cH:18][c:19]1[O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[CH:28]=[O:29])=[O:30].Br[Mg][c:31]1[cH:32][cH:33][cH:34][cH:35][n:36]1>C1CCOC1>[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][N:7]1[C:8]([CH2:9][N:10]([S:11]1(=[O:12])=[O:13])[c:14]1[cH:15][cH:16][c:17]([cH:18][c:19]1[O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[CH:28]([OH:29])[c:31]1[cH:32][cH:33][cH:34][cH:35][n:36]1)=[O:30]|EP3113772B1_0486
3.7.2|[C&H3&+0&D1:5]-[#12]-Br.[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][CH:2]([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11]([CH3:12])=[O:13].[CH3:14][Mg]Br>>[CH3:1][CH:2]([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11]([CH3:14])([CH3:12])[OH:13]|EP3122345B1_0232
1.3.6|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][NH:2][CH3:3].[CH3:4][NH:5][c:6]1[cH:7][c:8]([cH:9][c:10]([n:11]1)Br)[NH:12][S:13](=[O:14])(=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[NH2:22]>>[CH3:4][NH:5][c:6]1[cH:7][c:8]([cH:9][c:10]([n:11]1)[N:2]([CH3:1])[CH3:3])[NH:12][S:13](=[O:14])(=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[NH2:22]|US20200354345A1_0704
1.6.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][CH:3](Br)[C:4](=[O:5])[NH:6][c:7]1[c:8]([cH:9][cH:10][cH:11][c:12]1[CH3:13])[CH3:14].[CH3:15][NH:16][CH3:17]>O.CCOCC.CCO>[CH3:14][c:8]1[cH:9][cH:10][cH:11][c:12]([c:7]1[NH:6][C:4](=[O:5])[CH:3]([CH2:2][CH3:1])[N:16]([CH3:15])[CH3:17])[CH3:13]|US20040067311A1_0412
2.1.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[N:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[N:1]|[CH3:1][O:2][P:3](=[O:4])([NH:5][NH:6][C:7]([CH3:8])([CH3:9])[CH3:10])[O:11][CH3:12].[CH3:13][C:14](=[O:15])Cl>CCN(CC)CC.ClCCl>[CH3:1][O:2][P:3](=[O:4])([NH:5][N:6]([C:14]([CH3:13])=[O:15])[C:7]([CH3:8])([CH3:9])[CH3:10])[O:11][CH3:12]|US20190382383A1_0818
2.3.10|[C&H3&D1:5]-[N&H2&+0&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-c1:c:c:c:c:c:1>>[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|Br.[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([n:7][s:8][c:9]1[NH:10][C:11](=[O:12])Oc1ccccc1)[CH3:13].[CH3:14][NH2:15]>O.CCO>[CH3:14][NH:15][C:11](=[O:12])[NH:10][c:9]1[s:8][n:7][c:6]([c:5]1[C:3](=[O:4])[O:2][CH3:1])[CH3:13]|US09115093B2_0671
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17])[Cl:18].[O:19]=[C:20](Br)[CH2:21][Br:22]>CCOCC.CCOC(C)=O>[CH3:1][N:2]([C:20](=[O:19])[CH2:21][Br:22])[c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17])[Cl:18]|EP2121137B1_0340
2.3.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[CH2:14][CH2:15][NH:16][CH3:17].[CH3:18][N:19]([CH3:20])[C:21](=[O:22])Cl>CCN(CC)CC.Cc1ccccc1>[CH3:18][N:19]([CH3:20])[C:21](=[O:22])[N:16]([CH3:17])[CH2:15][CH2:14][N:11]1[CH2:10][CH2:9][N:8]([CH2:13][CH2:12]1)[C:6](=[O:7])[N:3]([CH2:4][CH3:5])[CH2:2][CH3:1]|US20100104659A1_1228
1.6.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[C:3]-[C&H1&+0&D3:2](-[c:1])-Br>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:2](-[C:3])-[c:1]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH2:12][CH2:13][CH:14](Br)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[CH3:21][NH:22][CH3:23]>>[CH3:21][N:22]([CH3:23])[CH:14]([CH2:13][CH2:12][O:11][c:8]1[cH:7][cH:6][c:5]([cH:10][cH:9]1)[C:2]([F:1])([F:3])[F:4])[c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|US09034866B2_0673
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[O:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[O:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[O:1]=[C:2](Cl)[CH2:3][O:4][N:5]=[CH:6][c:7]1[c:8]([cH:9][cH:10][cH:11][c:12]1[Cl:13])[Cl:14].[CH3:15][O:16][NH:17][CH3:18].Cl>Cc1ccccc1.CCN(CC)CC.CO>[CH3:15][O:16][N:17]([CH3:18])[C:2](=[O:1])[CH2:3][O:4][N:5]=[CH:6][c:7]1[c:12]([cH:11][cH:10][cH:9][c:8]1[Cl:14])[Cl:13]|US20200291042A1_0183
2.4.5|[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-Cl.[O&H1&D1:3]-[N&H1&+0&D2:2]-[c:1]>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[O:4])-[N&H0&+0&D3:2](-[O&H1&D1:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH:8][OH:9].[O:10]=[C:11](Cl)[O:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>O.[Na+].[O-]C(=O)O.ClCCl>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[N:8]([OH:9])[C:11](=[O:10])[O:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|US10676424B2_0625
1.2.17|[C:7]-[C&H1&+0&D2:6]=[C&H1&+0&D2:5]-[c:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:7]-[C&H2&+0&D2:6]-[C&H1&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[N:1]#[C:2][CH:3]=[CH:4][c:5]1[cH:6][cH:7][cH:8][o:9]1.[O:10]=[C:11]([NH:12][CH2:13][C:14]([F:15])([F:16])[F:17])[NH:18][c:19]1[cH:20][cH:21][cH:22][c:23]([cH:24]1)-[c:25]1[cH:26][n:27][c:28]2[cH:29][c:30]([cH:31][n:32][n:33]12)-[c:34]1[cH:35][n:36][nH:37][cH:38]1>>[N:1]#[C:2][CH2:3][CH:4]([c:5]1[cH:6][cH:7][cH:8][o:9]1)[n:37]1[cH:38][c:34]([cH:35][n:36]1)-[c:30]1[cH:31][n:32][n:33]2[c:25]([cH:26][n:27][c:28]2[cH:29]1)-[c:23]1[cH:22][cH:21][cH:20][c:19]([cH:24]1)[NH:18][C:11](=[O:10])[NH:12][CH2:13][C:14]([F:15])([F:16])[F:17]|US20200338077A1_0661
1.9.20|[C:6]-[O&H1&+0&D1:5].[C:4]-[P&H0&+0&D4:3](=[O&H0&D1:2])(-[O&H1&D1:1])-O>>[C:6]-[O&H0&+0&D2:5]-[P&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])-[O&H1&D1:1]|[O:1]=[C:2]([NH:3][CH2:4][CH2:5][CH2:6][CH2:7][C@H:8]([OH:9])[C:10](=[O:11])[N:12]1[CH2:13][CH2:14][CH2:15][C@H:16]1[C:17](=[O:18])[O:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[O:27][CH2:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1.[O:35]=[C:36]([NH:37][CH2:38][CH2:39][CH2:40][CH2:41][C@H:42]([NH:43][C:44](=[O:45])[CH:46]1[CH2:47][CH2:48][CH2:49]1)[C:50](=[O:51])[NH:52][CH:53]([CH2:54][c:55]1[cH:56][cH:57][cH:58][cH:59][cH:60]1)[P:61](=[O:62])([OH:63])O)[O:64][CH2:65][c:66]1[cH:67][cH:68][cH:69][cH:70][cH:71]1>C(=NC1CCCCC1)=NC1CCCCC1.c1ccncc1>[O:35]=[C:36]([NH:37][CH2:38][CH2:39][CH2:40][CH2:41][C@H:42]([NH:43][C:44](=[O:45])[CH:46]1[CH2:49][CH2:48][CH2:47]1)[C:50](=[O:51])[NH:52][CH:53]([CH2:54][c:55]1[cH:56][cH:57][cH:58][cH:59][cH:60]1)[P:61](=[O:62])([OH:63])[O:9][C@@H:8]([CH2:7][CH2:6][CH2:5][CH2:4][NH:3][C:2](=[O:1])[O:27][CH2:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)[C:10](=[O:11])[N:12]1[CH2:13][CH2:14][CH2:15][C@H:16]1[C:17](=[O:18])[O:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[O:64][CH2:65][c:66]1[cH:67][cH:68][cH:69][cH:70][cH:71]1|US07528173B2_0662
10.2.1|[O&H0&-&D1:6]-[N&H0&+&D3:5](=[O&H0&D1:4])-O.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[O&H0&-&D1:6]-[N&H0&+&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][n:7]1)[OH:8].[O-:9][N+:10](=[O:11])O>O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([n:7]1)[N+:10]([O-:9])=[O:11])[OH:8]|US10414757B2_0517
2.5.7|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-S-C>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][CH:2]([CH3:3])[n:4]1[c:5]([n:6][c:7]([n:8]([c:9]1=[O:10])[CH3:11])SC)=[O:12].[CH3:13][NH:14][CH3:15]>C1CCOC1>[CH3:1][CH:2]([CH3:3])[n:4]1[c:5]([n:6][c:7]([n:8]([c:9]1=[O:10])[CH3:11])[N:14]([CH3:13])[CH3:15])=[O:12]|US06281219B1
1.2.16|[C:7]-[N&H1&+0&D2:6]-[C:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H1&+0&D3:2](-[c:1])-[C&H2&+0&D2:3]-[C:4]|[CH3:1][CH2:2][NH:3][CH:4]=[C:5]([C:6](=[O:7])[CH:8]=[CH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16])[C:17](=[O:18])[O:19][CH3:20]>CN(C)C=O>[CH3:20][O:19][C:17](=[O:18])[C:5]1=[CH:4][N:3]([CH:9]([CH2:8][C:6]1=[O:7])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16])[CH2:2][CH3:1]|US20040266823A1_0260
1.2.16|[C:7]-[C&H1&+0&D2:6]=[C&H1&+0&D2:5]-[C:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:7]-[C&H2&+0&D2:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH:7]=[CH:8][C:9](=[O:10])[C:11]([CH3:12])([CH3:13])[CH3:14].[cH:15]1[n:16][cH:17][nH:18][n:19]1>Cc1ccccc1>[CH3:12][C:11]([CH3:13])([CH3:14])[C:9](=[O:10])[CH2:8][CH:7]([C:5](=[O:6])[C:2]([CH3:1])([CH3:3])[CH3:4])[n:18]1[cH:17][n:16][cH:15][n:19]1|US08940737B2_1806
2.2.3|[C:6]-[N&H2&+0&D1:5].[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-F>>[C:6]-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[O:1]=[S:2](=[O:3])(F)[C:4]([F:5])([F:6])[C:7]([F:8])([F:9])[C:10]([F:11])([F:12])[C:13]([F:14])([F:15])[C:16]([F:17])([F:18])[C:19]([F:20])([F:21])[F:22].[NH2:23][CH2:24][CH2:25][CH2:26][NH2:27]>CC(C)OC(C)C>[NH2:23][CH2:24][CH2:25][CH2:26][NH:27][S:2](=[O:1])(=[O:3])[C:4]([F:5])([F:6])[C:7]([F:8])([F:9])[C:10]([F:11])([F:12])[C:13]([F:14])([F:15])[C:16]([F:17])([F:18])[C:19]([F:20])([F:21])[F:22]|US20050084231A1_0211
2.7.2|[C:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-F.[C:2]-[O&H1&+0&D1:1]>>[C:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])[NH:4][CH:5]([CH2:6][OH:7])[C:8]([CH3:9])=[O:10].[O:11]=[S:12](=[O:13])(F)[CH2:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>>[CH3:1][C:2](=[O:3])[NH:4][CH:5]([CH2:6][O:7][S:12](=[O:11])(=[O:13])[CH2:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1)[C:8]([CH3:9])=[O:10]|US20140193752A1_0179
10.2.1|[C:6]-[C&H2&+0&D2:5]-[C:4].[O&H0&-&D1:3]-[N&H0&+&D3:2](=[O&H0&D1:1])-O>>[C:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+&D3:2](-[O&H0&-&D1:3])=[O&H0&D1:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[C:7]([CH2:8][C:9]([c:10]21)=[O:11])=[O:12].[O-:13][N+:14](=[O:15])O>CCOCC>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[C:7]([CH:8]([C:9]([c:10]12)=[O:11])[N+:14]([O-:13])=[O:15])=[O:12]|US20170107207A1_0492
3.11.45|[O&H0&+0&D1:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H1&+0&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[C:8]([CH3:9])([CH3:10])[CH3:11])[OH:12].[O:13]=[C:14]=[O:15]>Cc1ccccc1C.[Na]>[CH3:1][c:2]1[cH:7][c:6]([c:5]([c:4]([cH:3]1)[C:14](=[O:15])[OH:13])[OH:12])[C:8]([CH3:9])([CH3:10])[CH3:11]|US10844031B2_0142
1.2.17|[C:7]-[C&H0&+0&D2:6]#[C&H0&+0&D2:5]-[c:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H1&+0&D2:6]=[C&H0&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH2:11][c:12]2[cH:13][cH:14][c:15]([n:16][c:17]21)[CH2:18][CH2:19][O:20][c:21]1[cH:22][cH:23][c:24]2[nH:25][cH:26][cH:27][c:28]2[cH:29]1.[CH3:30][CH2:31][O:32][C:33](=[O:34])[C:35]#[C:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1>CCOC(C)=O.CN(C)C=O.F[Cs].O>[CH3:30][CH2:31][O:32][C:33](=[O:34])[CH:35]=[C:36]([c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[n:25]1[cH:26][cH:27][c:28]2[cH:29][c:21]([cH:22][cH:23][c:24]21)[O:20][CH2:19][CH2:18][c:15]1[cH:14][cH:13][c:12]2[CH2:11][CH2:10][CH2:9][N:8]([c:17]2[n:16]1)[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US08003806B2_0226
1.9.4|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5](Cl)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13].[Cl:14][c:15]1[cH:16][cH:17][c:18]([s:19]1)Br>CCCC[Li].C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[c:18]1[cH:17][cH:16][c:15]([s:19]1)[Cl:14]|US20030114666A1_1933
1.6.8|[C&H3&D1:6]-[C&H2&+0&D2:5]-I.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[C&H3&D1:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1][CH2:2]I.[CH3:3][CH:4]([C:5](=[O:6])[OH:7])[N:8]1[CH2:9][CH2:10][CH:11]=[C:12]([CH2:13]1)[c:14]1[n:15][n:16][n:17][nH:18]1>>[CH3:3][CH:4]([C:5](=[O:6])[OH:7])[N:8]1[CH2:9][CH2:10][CH:11]=[C:12]([CH2:13]1)[c:14]1[n:15][n:16][n:17]([n:18]1)[CH2:2][CH3:1]|US20120309750A1_0299
10.2.1|[O&H0&-&D1:6]-[N&H0&+&D3:5](=[O&H0&D1:4])-O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&-&D1:6]-[N&H0&+&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-:1][N+:2](=[O:3])O.[Cl:4][c:5]1[n:6][c:7]([cH:8][cH:9][c:10]1[Cl:11])[Cl:12]>O=S(=O)(O)O>[O-:1][N+:2](=[O:3])[c:8]1[cH:9][c:10]([c:5]([n:6][c:7]1[Cl:12])[Cl:4])[Cl:11]|US20020035137A1_0304
1.2.19|[C&H3&D1:6]-[C&H2&+0&D2:5]-[C&H1&+0&D2:4]=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][CH:3]=O.[CH2:4]1[CH2:5][NH:6][CH2:7][CH2:8][O:9]1>C=CCN1CCOCC1.CS(C)=O.O=C(O[K])O[K]>[CH3:1][CH:2]=[CH:3][N:6]1[CH2:7][CH2:8][O:9][CH2:4][CH2:5]1|EP0246669A2_0022
2.3.1|[N&H2&+0&D1:6]-[N:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[N&H1&+0&D2:6](-[N:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][N:2]1[CH2:3][CH2:4][CH2:5][O:6][C:7]1=[O:8].[O:9]=[C:10]=[N:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>CCCCCC.COCCOC>[O:8]=[C:7]1[O:6][CH2:5][CH2:4][CH2:3][N:2]1[NH:1][C:10](=[O:9])[NH:11][c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|EP1452526A1_0253
2.6.9|[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-O.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][CH2:2][C:3](=[O:4])[O:5][CH2:6][C:7](=[O:8])[OH:9].[CH3:10][C:11]([CH3:12])(O)[CH:13]1[CH2:14][CH2:15][CH2:16][C:17]([CH2:18]1)([CH3:19])[CH3:20]>CC(=O)C1CCCC(C1)(C)C.C[Mg]Cl.ClCCl.C(=NC1CCCCC1)=NC1CCCCC1>[CH3:1][CH2:2][C:3](=[O:4])[O:5][CH2:6][C:7](=[O:8])[O:9][C:11]([CH3:10])([CH3:12])[CH:13]1[CH2:14][CH2:15][CH2:16][C:17]([CH2:18]1)([CH3:19])[CH3:20]|US20050182273A1_0152
7.6.1|[C&H3&D1:6]/[C&H0&+0&D3:5](-[S:4])=[C&H0&+0&D3:3](/[C&H3&D1:2])-[c:1]>>[C&H3&D1:6]-[C@&H1&+0&D3:5](-[S:4])-[C@&H1&+0&D3:3](-[C&H3&D1:2])-[c:1]|[CH3:1]/[C:2](=[C:3](/[CH3:4])[S:5]([NH2:6])(=[O:7])=[O:8])[c:9]1[n:10][cH:11][c:12]([cH:13][n:14]1)[CH3:15]>>[CH3:15][c:12]1[cH:13][n:14][c:9]([n:10][cH:11]1)[C@@H:2]([CH3:1])[C@H:3]([CH3:4])[S:5]([NH2:6])(=[O:7])=[O:8]|US09845310B2_2796
2.3.1|[N&H2&+0&D1:6]-[c:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[N&H1&+0&D2:6](-[c:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][c:2]1[nH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[O:17]=[C:18]=[N:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>>[O:17]=[C:18]([NH:19][c:20]1[cH:25][cH:24][cH:23][cH:22][cH:21]1)[NH:1][c:2]1[nH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US07595325B2_0625
2.3.1|[N&H2&+0&D1:6]-[S:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[N&H1&+0&D2:6](-[S:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[S:12]([NH2:13])(=[O:14])=[O:15].[O:16]=[C:17]=[N:18][c:19]1[n:20][c:21]([n:22][c:23]([n:24]1)[Cl:25])[Cl:26]>CC#N>[CH3:1][C:2](=[O:3])[O:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[S:12](=[O:14])(=[O:15])[NH:13][C:17](=[O:16])[NH:18][c:19]1[n:24][c:23]([n:22][c:21]([n:20]1)[Cl:26])[Cl:25]|US20200291003A1_1866
1.2.16|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[C:4].[C&H3&D1:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[C:4])-[N&H0&+0&D3:2](-[C&H3&D1:3])-[C:1]|[CH2:1]=[CH:2][C:3](=[O:4])[O:5][CH2:6][CH3:7].[CH3:8][CH2:9][CH2:10][CH2:11][NH:12][CH3:13]>>[CH3:7][CH2:6][O:5][C:3](=[O:4])[CH2:2][CH2:1][N:12]([CH3:13])[CH2:11][CH2:10][CH2:9][CH3:8]|US20060276464A1_3955
1.9.4|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([n:14][cH:15]1)Br.[CH3:16][CH2:17][CH2:18][CH2:19][Sn:20](Cl)([CH2:21][CH2:22][CH2:23][CH3:24])[CH2:25][CH2:26][CH2:27][CH3:28]>CCCC[Li].C1CCOC1.O>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][CH2:9][c:10]1[cH:15][n:14][c:13]([cH:12][cH:11]1)[Sn:20]([CH2:21][CH2:22][CH2:23][CH3:24])([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:19][CH2:18][CH2:17][CH3:16]|US20200247812A1_0396
1.2.9|[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[CH:8]#[C:9][C:10]([CH3:11])([CH3:12])O>CN(C)c1ccncc1.CC(=O)OC(C)=O.CCN(CC)CC.ClCCl.Cl[Cu].[NH4+].[Cl-]>[CH:8]#[C:9][C:10]([CH3:11])([CH3:12])[NH:1][c:2]1[cH:7][cH:6][cH:5][cH:4][cH:3]1|US05688808A
1.9.20|[C:6]-[O&H1&+0&D1:5].[O&H0&D1:4]=[P&H0&+0&D4:3](-[O&H1&D1:2])(-[O:1])-O>>[C:6]-[O&H0&+0&D2:5]-[P&H0&+0&D4:3](=[O&H0&D1:4])(-[O&H1&D1:2])-[O:1]|[NH2:1][c:2]1[n:3][cH:4][n:5][c:6]2[c:7]1[n:8][cH:9][n:10]2[C@@H:11]1[O:12][C@@H:13]([C@H:14]([C@H:15]1[OH:16])[OH:17])[CH2:18][O:19][P:20](=[O:21])([OH:22])O>N#CSc1ccc(cc1)N>[NH2:1][c:2]1[n:3][cH:4][n:5][c:6]2[c:7]1[n:8][cH:9][n:10]2[C@@H:11]1[O:12][C@@H:13]2[CH2:18][O:19][P:20]([O:17][C@H:14]2[C@H:15]1[OH:16])(=[O:21])[OH:22]|US20200376077A1_0161
1.7.7|[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-O.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])(O)[C:4](=[O:5])[OH:6].[OH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[CH2:14][O:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>O.O=S(=O)(O)O>[CH3:1][C:2]([CH3:3])([O:7][c:8]1[cH:13][cH:12][c:11]([cH:10][cH:9]1)[CH2:14][O:15][c:16]1[cH:21][cH:20][cH:19][cH:18][cH:17]1)[C:4](=[O:5])[OH:6]|US20150274721A1_0381
1.9.4|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5](Cl)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13].Br[c:14]1[n:15][cH:16][cH:17][s:18]1>CCCC[Li].C1CCOC1>[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[c:14]1[n:15][cH:16][cH:17][s:18]1|US10377748B2_0908
2.3.1|[N&H2&+0&D1:6]-[c:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[S:1]>>[N&H1&+0&D2:6](-[c:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[S:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[N:11]=[C:12]=[O:13].[CH3:14][O:15][C:16](=[O:17])[NH:18][C:19](=[S:20])[NH:21][c:22]1[cH:23][c:24]([cH:25][cH:26][c:27]1[NH2:28])[C:29](=[O:30])[c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1>CC(C)=O>[CH3:14][O:15][C:16](=[O:17])[NH:18][C:19](=[S:20])[NH:21][c:22]1[cH:23][c:24]([cH:25][cH:26][c:27]1[NH:28][C:12](=[O:13])[NH:11][S:8](=[O:9])(=[O:10])[c:5]1[cH:6][cH:7][c:2]([cH:3][cH:4]1)[CH3:1])[C:29](=[O:30])[c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1|US05071470A
1.6.8|[C&H3&D1:6]-[C&H2&+0&D2:5]-I.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[c:1]>>[C&H3&D1:6]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1][CH2:2]I.[cH:3]1[n:4][nH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12>CN(C)C=O.[NaH]>[CH3:1][CH2:2][n:4]1[cH:3][c:11]2[cH:10][cH:9][cH:8][cH:7][c:6]2[n:5]1|EP3484889B1_0058
2.3.2|[N&H2&+0&D1:6]-[c:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[N&H1&+0&D2:6](-[c:5])-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[NH2:8].[S:9]=[C:10]=[N:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18]>ClC(Cl)Cl>[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[NH:8][C:10](=[S:9])[NH:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18]|EP3381907A1_0177
3.11.1|[C&H3&D1:6]-[C&H2&+0&D2:5]-[C:4].[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:11][CH2:12][O:13][C:14](=[O:15])[CH:16]=[O:17]>>[CH3:11][CH2:12][O:13][C:14](=[O:15])[CH:16]([OH:17])[CH:2]([CH3:1])[C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|EP3421463A1_0104
1.9.4|[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:7]-[#50&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5](Cl)([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:10][CH2:11][CH2:12][CH3:13].[CH3:14][c:15]1[cH:16][c:17]([cH:18][c:19]([n:20]1)[CH3:21])Br>CCOCC.CCCC[Li]>[CH3:1][CH2:2][CH2:3][CH2:4][Sn:5]([CH2:6][CH2:7][CH2:8][CH3:9])([CH2:10][CH2:11][CH2:12][CH3:13])[c:17]1[cH:16][c:15]([n:20][c:19]([cH:18]1)[CH3:21])[CH3:14]|US20200360353A1_1419
10.2.1|[O&H0&-&D1:6]-[N&H0&+&D3:5](=[O&H0&D1:4])-O.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[O&H0&-&D1:6]-[N&H0&+&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[O-:1][N+:2](=[O:3])O.[O:4]=[c:5]1[n:6][c:7]([c:8]2[cH:9][cH:10][s:11][c:12]2[n:13]1[CH2:14][CH:15]1[CH2:16][CH2:17]1)-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>N.CC(=O)OC(C)=O>[O-:1][N+:2](=[O:3])[c:10]1[cH:9][c:8]2[c:7]([n:6][c:5]([n:13]([c:12]2[s:11]1)[CH2:14][CH:15]1[CH2:16][CH2:17]1)=[O:4])-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20190084975A1_0285
2.2.3|[C:6]-[N&H3&+&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C:6]-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[Cl-].[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])Cl.[NH3+:11][C@@H:12]1[CH2:13][CH2:14][CH2:15][CH2:16][C@H:17]1[O:18][CH2:19][C:20](=[O:21])[OH:22]>[Na+].CCOCC.[OH-]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][C@@H:12]1[CH2:13][CH2:14][CH2:15][CH2:16][C@H:17]1[O:18][CH2:19][C:20](=[O:21])[OH:22]|US20200345749A1_0153
3.11.46|[C&H2&D1:6]=[C&H1&+0&D2:5]-[C:4].[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H2&D1:6]=[C&H0&+0&D3:5](-[C:4])-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[O:1]=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.[CH2:13]=[CH:14][C:15](=[O:16])[O:17][CH3:18]>C1CN2CCN1CC2>[CH2:13]=[C:14]([C:15](=[O:16])[O:17][CH3:18])[CH:2]([OH:1])[CH2:3][CH2:4][CH2:5][CH2:6][c:7]1[cH:12][cH:11][cH:10][cH:9][cH:8]1|US20170313669A1_0344
1.2.16|[C:7]-[C&H1&+0&D2:6]=[C&H1&+0&D2:5]-[C:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[C&H1&+0&D3:6](-[C&H2&+0&D2:5]-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][N:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1.[O:8]=[C:9]1[CH:10]=[CH:11][CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]12>CCO>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH:11]1[CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]2[C:9]([CH2:10]1)=[O:8]|US10100059B2_0406
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[S:4].[C&H3&D1:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[S:4])-[N&H0&+0&D3:2](-[C&H3&D1:3])-[C:1]|[CH2:1]=[CH:2][S:3](=[O:4])(=[O:5])[F:6].[CH3:7][O:8][c:9]1[cH:10][c:11]([cH:12][cH:13][c:14]1[O:15][CH3:16])[CH2:17][CH2:18][NH:19][CH3:20]>CN(C)C=O>[CH3:7][O:8][c:9]1[cH:10][c:11]([cH:12][cH:13][c:14]1[O:15][CH3:16])[CH2:17][CH2:18][N:19]([CH3:20])[CH2:1][CH2:2][S:3](=[O:4])(=[O:5])[F:6]|US20100069417A1_0325
2.3.2|[N&H2&+0&D1:6]-[N:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[N&H1&+0&D2:6](-[N:5])-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][NH:2][CH:3]=[O:4].[F:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[N:12]=[C:13]=[S:14]>C1CCOC1>[O:4]=[CH:3][NH:2][NH:1][C:13](=[S:14])[NH:12][c:11]1[cH:10][cH:9][cH:8][cH:7][c:6]1[F:5]|US20200339559A1_0684
1.2.17|[N&H2&+0&D1:6]-[O&H1&D1:5].[S:4]/[C&H1&+0&D2:3]=[C&H1&+0&D2:2]/[c:1]>>[N&H1&+0&D2:6](-[O&H1&D1:5])-[C&H1&+0&D3:2](-[c:1])-[C&H2&+0&D2:3]-[S:4]|[NH2:1][OH:2].[O:3]=[S:4](=[O:5])(/[CH:6]=[CH:7]/[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[N:14]1[CH2:15][CH2:16][N:17]([CH2:18][CH2:19]1)[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[F:26]>C1CCOC1>[O:3]=[S:4](=[O:5])([CH2:6][CH:7]([NH:1][OH:2])[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[N:14]1[CH2:15][CH2:16][N:17]([CH2:18][CH2:19]1)[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[F:26]|US20060142336A1_0491
3.1.6|[c:6]:[c&H0&+0&D3:5](:[c:4])-B1-O-C-C(-C)(-C)-C-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|CC1(COB(OC1)[c:1]1[cH:2][cH:3][c:4]([c:5]([cH:6]1)-[c:7]1[cH:8][cH:9][c:10]([cH:11][c:12]1[C:13]#[N:14])[F:15])[F:16])C.[F:17][C:18]([F:19])([F:20])[c:21]1[cH:22][cH:23][c:24]2[c:25]([n:26][cH:27][cH:28][c:29]2Cl)[n:30]1>>[N:14]#[C:13][c:12]1[cH:11][c:10]([cH:9][cH:8][c:7]1-[c:5]1[cH:6][c:1]([cH:2][cH:3][c:4]1[F:16])-[c:29]1[cH:28][cH:27][n:26][c:25]2[n:30][c:21]([cH:22][cH:23][c:24]12)[C:18]([F:17])([F:19])[F:20])[F:15]|EP1532120B1_0166
1.2.17|[C:7]-[C&H1&+0&D2:6]=[C&H1&+0&D2:5]-[O:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[C&H1&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH:1]1=[CH:2][O:3][CH2:4][CH2:5][CH2:6]1.[cH:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[n:14][cH:15][nH:16][c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>CCOCC.CCOC(C)=O.FB(F)F>[cH:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[n:14][cH:15][n:16]([c:17]1-[c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1)[CH:2]1[CH2:1][CH2:6][CH2:5][CH2:4][O:3]1|US20200157105A1_0063
2.2.4|[C:6]-[N&H2&+0&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-O>>[C:6]-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][n:6][cH:7][c:8]([cH:9]1)[S:10](=[O:11])(=[O:12])O.[CH3:13][CH2:14][NH2:15]>ClP(Cl)(Cl)(Cl)Cl.O=P(Cl)(Cl)Cl.O>[CH3:13][CH2:14][NH:15][S:10](=[O:11])(=[O:12])[c:8]1[cH:7][n:6][cH:5][c:4]([cH:9]1)[N+:2]([O-:1])=[O:3]|EP0853618B1_0083
10.2.1|[C:6]=[C&H1&+0&D2:5]-[C:4].[O&H0&-&D1:3]-[N&H0&+&D3:2](=[O&H0&D1:1])-O>>[C:6]=[C&H0&+0&D3:5](-[C:4])-[N&H0&+&D3:2](-[O&H0&-&D1:3])=[O&H0&D1:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[C:7]([CH:8]=[C:9]([C:10]([c:11]12)=[O:12])[OH:13])=[O:14].[O-:15][N+:16](=[O:17])O>ClC(Cl)Cl>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[C:7]([C:8](=[C:9]([C:10]([c:11]12)=[O:12])[OH:13])[N+:16]([O-:15])=[O:17])=[O:14]|US20080242661A1_0409
1.2.17|[C:7]-[C&H1&+0&D2:6]=[C&H1&+0&D2:5]-[O:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:7]-[C&H2&+0&D2:6]-[C&H1&+0&D3:5](-[O:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[OH:1][c:2]1[cH:3][c:4]([n:5][nH:6]1)[C:7]([F:8])([F:9])[F:10].[CH:11]1=[CH:12][O:13][CH2:14][CH2:15][CH2:16]1>Cc1ccc(cc1)S(=O)(=O)O.CCOC(C)=O.O>[OH:1][c:2]1[cH:3][c:4]([n:5][n:6]1[CH:12]1[CH2:11][CH2:16][CH2:15][CH2:14][O:13]1)[C:7]([F:8])([F:9])[F:10]|EP2807162B1_0153
2.7.2|[C:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-F.[O&H1&+0&D1:2]-[c:1]>>[C:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][c:9]1[cH:10][n:11][c:12]([n:13][cH:14]1)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[OH:21].[O:22]=[S:23](=[O:24])(F)[C:25]([F:26])([F:27])[C:28]([F:29])([F:30])[C:31]([F:32])([F:33])[C:34]([F:35])([F:36])[F:37]>[N-]=[N+]1C2CCCC11CCCCCC=21.COC(C)(C)C.O>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][c:9]1[cH:10][n:11][c:12]([n:13][cH:14]1)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[O:21][S:23](=[O:22])(=[O:24])[C:25]([F:26])([F:27])[C:28]([F:29])([F:30])[C:31]([F:32])([F:33])[C:34]([F:35])([F:36])[F:37]|US20200128827A1_0238
2.2.3|[C:6]-[N&H2&+0&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-F>>[C:6]-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])F.[CH3:11][CH:12]([CH3:13])[NH:14][CH2:15][CH2:16][CH2:17][NH2:18]>CCN(CC)CC.CCCCO>[CH3:11][CH:12]([CH3:13])[NH:14][CH2:15][CH2:16][CH2:17][NH:18][S:8](=[O:9])(=[O:10])[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[NH2:1]|US20040176431A1_0292
2.3.10|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][NH:2][C:3]1([C:4]([N:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21)[CH:12]1[CH2:13][CH2:14][N:15]([CH2:16][CH2:17]1)[CH:18]1[CH2:19][c:20]2[cH:21][cH:22][cH:23][c:24]3[cH:25][cH:26][cH:27][c:28]1[c:29]23)=[O:30])[CH2:31][NH:32][C:33](=[O:34])OC>CO.O=C(O[Cs])O[Cs]>[CH3:1][N:2]1[C:33]([NH:32][CH2:31][C:3]11[C:4]([N:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21)[CH:12]1[CH2:13][CH2:14][N:15]([CH2:16][CH2:17]1)[CH:18]1[CH2:19][c:20]2[cH:21][cH:22][cH:23][c:24]3[cH:25][cH:26][cH:27][c:28]1[c:29]23)=[O:30])=[O:34]|US20200147083A1_0615
3.11.1|[C&H3&D1:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]1([O:3][CH2:4][CH2:5][C:6]2([CH2:7][C:8]([N:9]21)=[O:10])[CH3:11])[CH3:12].[CH3:13][CH:14]=[O:15]>CC(C)N(C(C)C)[Li].C1CCOC1.Cl[Na].O>[CH3:13][CH:14]([OH:15])[CH:7]1[C:8]([N:9]2[C:2]([O:3][CH2:4][CH2:5][C:6]12[CH3:11])([CH3:12])[CH3:1])=[O:10]|EP2177505A1_0050
1.2.16|[C:7]-[C&H1&+0&D2:6]=[C&H1&+0&D2:5]-[C:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[C&H1&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]1[CH:3]=[CH:4][CH2:5][CH2:6]1.[O:7]=[c:8]1[nH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[n:16]2[cH:17][cH:18][cH:19][c:20]12>C1CCOC1.[NaH]>[O:1]=[C:2]1[CH2:6][CH2:5][CH:4]([CH2:3]1)[n:9]1[c:8]([c:20]2[cH:19][cH:18][cH:17][n:16]2[c:15]2[cH:14][cH:13][cH:12][cH:11][c:10]21)=[O:7]|US09394297B2_1660
1.6.2|[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-Br.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[N&H1&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])Br.[NH2:9][CH2:10][CH2:11][O:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>O.CN1CCCC1=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])[NH:9][CH2:10][CH2:11][O:12][CH2:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|US20060025589A1_0176
2.7.2|[C:6]-[O&H1&+0&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C:6]-[O&H0&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])Cl.[OH:11][CH2:12][CH:13]1[CH2:14][N:15]([CH2:16][CH2:17][O:18]1)[CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>c1ccncc1>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[O:11][CH2:12][CH:13]1[CH2:14][N:15]([CH2:16][CH2:17][O:18]1)[CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US04018811A
2.1.1|[C:6]-[N&H1&+0&D2:5]-[C:4].[Cl&H0&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[Cl&H0&D1:3])=[O&H0&D1:1]|[O:1]=[C:2]([Cl:3])Cl.[O:4]=[S:5](=[O:6])([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[N:13]1[CH2:14][CH2:15][NH:16][C:17]1=[O:18]>ClCCl.c1ccncc1>[O:18]=[C:17]1[N:16]([CH2:15][CH2:14][N:13]1[S:5](=[O:4])(=[O:6])[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[C:2](=[O:1])[Cl:3]|US03996397A
1.2.14|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[NH:8][CH3:9].[CH3:10][CH:11]1[CH2:12][O:13]1>CO>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[N:8]([CH3:9])[CH2:12][CH:11]([CH3:10])[OH:13]|US20180339983A1_0700
2.2.3|[C:6]-[N&H2&+0&D1:5].[N:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:6]-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](-[N:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])Cl.[CH3:7][C:8]([CH3:9])([NH2:10])[CH2:11][NH2:12]>CCN(CC)CC.CCOCC>[CH3:7][C:8]([CH3:9])([NH2:10])[CH2:11][NH:12][S:4](=[O:5])(=[O:6])[N:2]([CH3:1])[CH3:3]|US06635771B2
2.7.2|[C:6]-[O&H1&+0&D1:5].[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:6]-[O&H0&+0&D2:5]-[S&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][CH2:2][S:3](=[O:4])(=[O:5])Cl.[OH:6][CH2:7][CH2:8][Br:9]>CCN(CC)CC.CCOCC>[CH3:1][CH2:2][S:3](=[O:4])(=[O:5])[O:6][CH2:7][CH2:8][Br:9]|US20190153107A1_1111
2.2.3|[C:6]-[N&H2&+0&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C:6]-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|Cl.[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])Cl.[NH2:11][CH2:12][CH2:13][S:14][c:15]1[cH:16][cH:17][cH:18][cH:19][n+:20]1[O-:21]>O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][CH2:12][CH2:13][S:14][c:15]1[cH:16][cH:17][cH:18][cH:19][n+:20]1[O-:21]|US20110046113A1_0576
2.2.3|[C:6]=[N&H1&+0&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C:6]=[N&H0&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[O:1]=[S:2](=[O:3])(Cl)[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[O:10][CH:11]([F:12])[F:13].[CH3:14][CH2:15][O:16][C:17](=[NH:18])[O:19][CH2:20][CH3:21]>CCN(CC)CC.CC(C)=O>[CH3:14][CH2:15][O:16][C:17](=[N:18][S:2](=[O:1])(=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[O:10][CH:11]([F:12])[F:13])[O:19][CH2:20][CH3:21]|US10662156B2_1014
1.2.16|[C:7]-[C&H1&+0&D2:6]=[C&H1&+0&D2:5]-[c:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[C&H2&+0&D2:6]-[C@&H1&+0&D3:5](-[c:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]=[CH:7][c:8]1[cH:9][cH:10][c:11]2[cH:12][cH:13][o:14][c:15]2[cH:16]1.[CH3:17][C@@H:18]([NH:19][CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>[NH4+].[Cl-].CCCC[Li].C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C@@H:7]([c:8]1[cH:9][cH:10][c:11]2[cH:12][cH:13][o:14][c:15]2[cH:16]1)[N:19]([CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[C@H:18]([CH3:17])[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1|US10875875B2_0746
2.7.2|[C:6]-[O&H1&+0&D1:5].[N:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:6]-[O&H0&+0&D2:5]-[S&H0&+0&D4:3](-[N:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][c:2]1[s:3][cH:4][c:5]([c:6]1[N:7]([C:8](=[O:9])[CH2:10][OH:11])[C@@H:12]([CH3:13])[C:14](=[O:15])[O:16][CH3:17])[CH3:18].[CH3:19][N:20]([CH3:21])[S:22](=[O:23])(=[O:24])Cl>COCCOC.[NaH]>[CH3:17][O:16][C:14](=[O:15])[C@H:12]([CH3:13])[N:7]([C:8](=[O:9])[CH2:10][O:11][S:22](=[O:23])(=[O:24])[N:20]([CH3:19])[CH3:21])[c:6]1[c:5]([cH:4][s:3][c:2]1[CH3:1])[CH3:18]|US20180066081A1_0161
3.7.2|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#12]-Br>>[O&H1&+0&D1:6]-[C&H1&+0&D3:5](-[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][c:2]1[cH:3][cH:4][n:5][c:6]([cH:7]1)[CH:8]=[O:9].Br[Mg][CH:10]1[CH2:11][CH2:12]1>>[CH3:1][c:2]1[cH:3][cH:4][n:5][c:6]([cH:7]1)[CH:8]([OH:9])[CH:10]1[CH2:11][CH2:12]1|US08536168B2_0416
2.7.2|[O&H0&D1:6]=[S&H0&+0&D4:5](=[O&H0&D1:4])(-[c:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[O&H0&D1:6]=[S&H0&+0&D4:5](=[O&H0&D1:4])(-[O&H0&+0&D2:2]-[c:1])-[c:3]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])Cl.[CH3:11][C@:12]12[CH2:13][CH2:14][C@@H:15]3[c:16]4[cH:17][cH:18][c:19]([cH:20][c:21]4[CH2:22][CH2:23][C@H:24]3[C@@H:25]1[CH2:26][CH2:27][C:28]2=[O:29])[OH:30]>O.c1ccncc1>[CH3:11][C@:12]12[CH2:13][CH2:14][C@@H:15]3[c:16]4[cH:17][cH:18][c:19]([cH:20][c:21]4[CH2:22][CH2:23][C@H:24]3[C@@H:25]1[CH2:26][CH2:27][C:28]2=[O:29])[O:30][S:8](=[O:9])(=[O:10])[c:5]1[cH:6][cH:7][c:2]([cH:3][cH:4]1)[CH3:1]|US08445530B2_0382
2.1.10|[N&H2&+0&D1:5]-[N&H2&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-O-c1:c:c:c:c:c:1>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][N:2]1[C:3]([CH2:4][CH:5]([CH2:6][C:7]1([CH3:8])[CH3:9])[O:10][C:11](=[O:12])Oc1ccccc1)([CH3:13])[CH3:14].[NH2:15][NH2:16]>CO>[CH3:1][N:2]1[C:3]([CH2:4][CH:5]([CH2:6][C:7]1([CH3:8])[CH3:9])[O:10][C:11](=[O:12])[NH:15][NH2:16])([CH3:13])[CH3:14]|US05338853A
2.1.10|[N&H2&+0&D1:5]-[N&H2&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-c1:c:c:c:c:c:1>>[N&H1&+0&D2:5](-[N&H2&D1:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[NH:15][C:16](=[O:17])Oc1ccccc1.[NH2:18][NH2:19]>C1COCCO1>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[NH:15][C:16](=[O:17])[NH:18][NH2:19]|US20200317649A1_0271
1.3.5|[C:6]=[C&H0&+0&D3:5](-[C:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:6]=[C&H0&+0&D3:5](-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|CC1(OB(OC1(C)C)[C:1]1=[CH:2][CH2:3][C:4]2([CH2:5][CH2:6]1)[CH2:7][CH2:8][CH2:9][O:10]2)C.[O-:11][N+:12](=[O:13])[c:14]1[cH:15][cH:16][cH:17][nH:18][c:19]1=[O:20]>CC([O-])=O.CC([O-])=O.CC#N.CCO.[Cu+2]>[O-:11][N+:12](=[O:13])[c:14]1[cH:15][cH:16][cH:17][n:18]([c:19]1=[O:20])[C:1]1=[CH:2][CH2:3][C:4]2([CH2:7][CH2:8][CH2:9][O:10]2)[CH2:5][CH2:6]1|US10844049B2_0730
1.8.12|[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-Br.[S&H1&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[S&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])Br.[SH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Br:16]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])[S:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Br:16]|US20200347022A1_0413
1.2.13|[C:7]-[N&H0&+0&D3:6]1-[C&H2&+0&D2:5]-[C:4]-1.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[N&H1&+0&D2:6]-[C:4]-[C&H2&+0&D2:5]-[N&H0&+0&D3:2](-[C:3])-[C:1]|[O:1]=[C:2]1[NH:3][CH2:4][N:5]([C:6]11[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[O:18]=[C:19]([c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[Cl:26])[N:27]1[CH2:28][CH2:29]1>c1ccccc1.CO>[O:1]=[C:2]1[NH:3][CH2:4][N:5]([C:6]11[CH2:11][CH2:10][N:9]([CH2:8][CH2:7]1)[CH2:29][CH2:28][NH:27][C:19](=[O:18])[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[Cl:26])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US20030212095A1_0450
1.8.12|[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-Br.[C:2]-[S&H1&+0&D1:1]>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[S&H0&+0&D2:1]-[C:2]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][SH:19].[CH3:20][CH2:21][O:22][C:23](=[O:24])[CH2:25][C:26](=[O:27])[C:28]([CH3:29])([CH3:30])Br>c1ccccc1.[NaH]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][S:19][C:28]([CH3:29])([CH3:30])[C:26](=[O:27])[CH2:25][C:23](=[O:24])[O:22][CH2:21][CH3:20]|US20100234351A1_1567
4.1.13|[N&H2&+0&D1:6]-[c:5]:[c:4]-[C&H2&+0&D2:3]-[S:2].[N&H0&+0&D2:1](=O)-O-[#11]>>[n&H1&+0&D2:6]1:[n&H0&+0&D2:1]:[c&H0&+0&D3:3](-[S:2]):[c:4]:[c:5]:1|[CH3:1][S:2](=[O:3])[CH2:4][c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[NH2:11])[C:12]([F:13])([F:14])[F:15].O=[N:16]O[Na]>O=S(=O)(O)O.CCCO.O.O.O>[CH3:1][S:2](=[O:3])[c:4]1[n:16][nH:11][c:10]2[cH:9][cH:8][c:7]([cH:6][c:5]12)[C:12]([F:13])([F:14])[F:15]|US07723329B2_0530
2.2.3|[C:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[c:1]>>[C:6]-[S&H0&+0&D4:5](-[N&H1&+0&D2:2]-[c:1])(=[O&H0&D1:4])=[O&H0&D1:3]|[CH3:1][NH:2][C:3](=[O:4])[O:5][c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[CH3:12])[NH2:13].[CH3:14][CH2:15][S:16](=[O:17])(=[O:18])Cl>O.c1ccncc1>[CH3:14][CH2:15][S:16](=[O:17])(=[O:18])[NH:13][c:9]1[cH:8][cH:7][c:6]([cH:11][c:10]1[CH3:12])[O:5][C:3](=[O:4])[NH:2][CH3:1]|US20130096149A1_0276
2.3.10|[N:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O-c1:c:c:c:c:c:1.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[N:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][NH:3][C:4](=[O:5])Oc1ccccc1.[NH2:6][c:7]1[n:8][cH:9][cH:10][c:11]([n:12]1)[O:13][c:14]1[cH:15][cH:16][c:17]2[nH:18][cH:19][cH:20][c:21]2[cH:22]1>CN(C)C=O.[NaH]>[CH3:1][CH2:2][NH:3][C:4](=[O:5])[n:18]1[cH:19][cH:20][c:21]2[cH:22][c:14]([cH:15][cH:16][c:17]21)[O:13][c:11]1[cH:10][cH:9][n:8][c:7]([n:12]1)[NH2:6]|US09604969B2_0386
3.5.3|[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[#30&+].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[c:2]1[c:3]([cH:4][c:5]([cH:6][n:7]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1)Br.[CH2:20]1[CH:21]2[CH2:22][CH:23]3[CH2:24][CH:25]1[CH2:26][C:27]([CH2:28]2)([CH2:29]3)[Zn+].[Br-]>[CH]1[CH][CH][C]([CH]1)P(c1ccccc1)c1ccccc1.[CH]1[CH][CH][C]([CH]1)P(c1ccccc1)c1ccccc1.C1CCOC1.Cl[Pd]Cl.I[Cu].N.[Fe]>[O:1]=[c:2]1[c:3]([cH:4][c:5]([cH:6][n:7]1-[c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1)-[c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1)[C:27]12[CH2:26][CH:25]3[CH2:20][CH:21]([CH2:28]2)[CH2:22][CH:23]([CH2:24]3)[CH2:29]1|US20190077784A1_2249
2.1.1|[C:6]-[N&H1&+0&D2:5]-[c:4].[Cl&H0&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[Cl&H0&D1:3])=[O&H0&D1:1]|[CH3:1][CH:2]([CH3:3])[NH:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[O:11]=[C:12]([Cl:13])Cl>c1ccccc1>[CH3:1][CH:2]([CH3:3])[N:4]([C:12](=[O:11])[Cl:13])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|US07749992B2_0524
2.7.2|[N:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[N:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][C:2]1([c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[O:9][CH:10]1[N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1)[OH:17])[CH3:18].[CH3:19][NH:20][S:21](=[O:22])(=[O:23])Cl>CCN(CC)CC.C1CCOC1>[CH3:1][C:2]1([c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[O:9][CH:10]1[N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1)[O:17][S:21](=[O:22])(=[O:23])[NH:20][CH3:19])[CH3:18]|US20080293718A1_0938
2.7.2|[C:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][C:2]1([CH2:3][O:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[OH:11])[CH3:12].[CH3:13][CH2:14][S:15](=[O:16])(=[O:17])Cl>CCN(CC)CC>[CH3:1][C:2]1([CH2:3][O:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[O:11][S:15](=[O:16])(=[O:17])[CH2:14][CH3:13])[CH3:12]|EP2831053B1_0603
10.4.17|[O:6]-[B&H0&+0&D3:5](-[O:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O:6]-[B&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])B1OC(C(O1)(C)C)(C)C)[CH3:9].[CH3:10][O:11][c:12]1[cH:13][cH:14][cH:15][c:16]([n:17]1)[Cl:18]>>[CH3:10][O:11][c:12]1[cH:13][c:14]([cH:15][c:16]([n:17]1)[Cl:18])[B:4]1[O:3][C:2]([C:6]([O:5]1)([CH3:7])[CH3:8])([CH3:1])[CH3:9]|EP3539966A1_0336
1.6.2|[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-Br.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](=[O:8])[NH:9][CH2:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[NH2:18].[CH3:19][C:20]([CH3:21])([CH3:22])[O:23][C:24](=[O:25])[C:26]([CH3:27])([CH3:28])Br>O=C(O[Cs])O[Cs].CN(C)C=O.O>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](=[O:8])[NH:9][CH2:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[NH:18][C:26]([CH3:28])([CH3:27])[C:24](=[O:25])[O:23][C:20]([CH3:19])([CH3:21])[CH3:22]|US20200360523A1_0459
1.2.20|[C:6]-[N&H1&+0&D2:5]-[C:4].[N:3]-[C&H0&+0&D3:2](=[S&H0&D1:1])-O-c1:c:c:c:c:c:1>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N:3])=[S&H0&D1:1]|[CH3:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[c:8]1[cH:9][c:10]2[n:11][c:12]([s:13][c:14]2[cH:15][c:16]1[NH:17][C:18](=[S:19])Oc1ccccc1)[C:20]([CH3:21])([CH3:22])[CH3:23].[CH3:24][N:25]1[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]1>C1COCCO1>[CH3:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[c:8]1[cH:9][c:10]2[n:11][c:12]([s:13][c:14]2[cH:15][c:16]1[NH:17][C:18](=[S:19])[N:28]1[CH2:27][CH2:26][N:25]([CH2:30][CH2:29]1)[CH3:24])[C:20]([CH3:21])([CH3:22])[CH3:23]|EP0850222B1_0238
10.4.17|[O:6]-[B&H0&+0&D3:5](-[O:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[O:6]-[B&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])B1OC(C(O1)(C)C)(C)C)[CH3:9].[F:10][c:11]1[cH:12][cH:13][cH:14][c:15]2[cH:16][cH:17][nH:18][c:19]12>CC(C)(C)c1ccnc(c1)-c1cc(ccn1)C(C)(C)C.CCCCCC>[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])[c:17]1[cH:16][c:15]2[cH:14][cH:13][cH:12][c:11]([c:19]2[nH:18]1)[F:10])[CH3:9]|US20200369656A1_0103
3.7.2|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#12]-Br>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][C:2]([CH3:3])([NH:4][C:5](=[O:6])[CH2:7][n:8]1[n:9][c:10]([n:11]([c:12]1=[O:13])[CH2:14][CH:15]=[O:16])-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23])[c:24]1[cH:25][cH:26][cH:27][c:28]([cH:29]1)[C:30]([F:31])([F:32])[F:33].Br[Mg][CH:34]1[CH2:35][CH2:36]1>C1CCOC1.[NH4+].[Cl-]>[CH3:1][C:2]([CH3:3])([NH:4][C:5](=[O:6])[CH2:7][n:8]1[n:9][c:10]([n:11]([c:12]1=[O:13])[CH2:14][CH:15]([OH:16])[CH:34]1[CH2:35][CH2:36]1)-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23])[c:24]1[cH:25][cH:26][cH:27][c:28]([cH:29]1)[C:30]([F:31])([F:32])[F:33]|US20200165201A1_0221
2.2.3|[C:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-Cl.[C:2]-[N&H2&+0&D1:1]>>[C:6]-[S&H0&+0&D4:5](-[N&H1&+0&D2:1]-[C:2])(=[O&H0&D1:4])=[O&H0&D1:3]|Cl.[CH3:1][C:2](=[NH:3])[NH2:4].[O:5]=[S:6](=[O:7])(Cl)[CH:8]=[CH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>CC(C)=O.O[Na]>[CH3:1][C:2](=[NH:3])[NH:4][S:6](=[O:5])(=[O:7])[CH:8]=[CH:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US06797708B2
4.1.45|[C:7]-[C&H1&+0&D2:6]=O.[C:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D3:4]:1-[C:5]|[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[NH:8][CH2:9][CH2:10][CH2:11][OH:12])[Cl:13].O=[CH:14][CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[OH:12][CH2:11][CH2:10][CH2:9][n:8]1[c:7]2[cH:6][cH:5][c:4]([cH:3][c:2]2[n:1][c:14]1[CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1)[Cl:13]|US20200216445A1_0798
2.1.1|[Cl&H0&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[c:3]-[N&H1&+0&D2:2]-[c:1]>>[Cl&H0&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH:1]1=[CH:2][c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[NH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]12.[O:16]=[C:17]([Cl:18])Cl>Cc1ccccc1.c1ccccc1.C>[O:16]=[C:17]([Cl:18])[N:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[CH:1]=[CH:2][c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]21|EP0273239B1_0076
1.2.13|[S:7]-[N&H0&+0&D3:6]1-[C&H2&+0&D2:5]-[C:4]-1.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[S:7]-[N&H1&+0&D2:6]-[C:4]-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[CH3:8])[S:9](=[O:10])(=[O:11])[N:12]1[CH2:13][CH:14]1[C:15]([F:16])([F:17])[F:18])[CH3:19].[cH:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)-[c:26]1[cH:27][nH:28][c:29]2[cH:30][cH:31][cH:32][cH:33][c:34]12>CCOC(C)=O.CN(C)C=O.C1CN1.[H][H].[NaH]>[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[CH3:8])[S:9](=[O:10])(=[O:11])[NH:12][CH:14]([CH2:13][n:28]1[cH:27][c:26]([c:34]2[cH:33][cH:32][cH:31][cH:30][c:29]21)-[c:23]1[cH:24][cH:25][cH:20][cH:21][cH:22]1)[C:15]([F:16])([F:17])[F:18])[CH3:19]|US20110288084A1_0227
1.6.2|[c:7]-[C&H2&+0&D2:6]-Br.[c:5]:[n&H1&+0&D2:4]:[c:3]:[n&H0&+0&D2:2]:[c:1]>>[c:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:[c:5]|[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[n:6][c:7]([c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[nH:14]1)[CH3:15])=[O:16].[N:17]#[C:18][c:19]1[cH:20][n:21][cH:22][cH:23][c:24]1-[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[CH2:31]Br>[Na+].CC(=O)O.CN(C)C=O.ClCCl.[H-].[Na]>[CH3:15][c:10]1[cH:11][cH:12][c:13]2[n:14][c:5]([n:6]([c:7]([c:8]2[cH:9]1)=[O:16])[CH2:31][c:28]1[cH:27][cH:26][c:25]([cH:30][cH:29]1)-[c:24]1[cH:23][cH:22][n:21][cH:20][c:19]1[C:18]#[N:17])[CH2:4][CH2:3][CH2:2][CH3:1]|US20030186978A1_0126
4.1.13|[C&H3&+0&D1:5]-[c:4]:[c:3]-[N&H1&+0&D2:2]-C(-C)=O.[N&H0&+0&D2:1](=O)-O-C-C-C(-C)-C>>[c&H1&+0&D2:5]1:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c:3]:[c:4]:1|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[CH3:8])[NH:9]C(C)=O)[CH3:10].CC(C)CCO[N:11]=O>CC(=O)O.Cc1ccccc1>[CH3:10][c:4]1[cH:3][c:2]([cH:7][c:6]2[cH:8][n:11][nH:9][c:5]12)[CH3:1]|US10336755B2_0122
1.2.14|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[CH3:1][NH:2][CH2:3][C:4]#[C:5][C:6]1=[CH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[S:14][c:15]2[cH:16][cH:17][c:18]([cH:19][c:20]12)[Cl:21].[CH2:22]1[CH2:23][O:24]1>CCO>[CH3:1][N:2]([CH2:3][C:4]#[C:5][C:6]1=[CH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[S:14][c:15]2[cH:16][cH:17][c:18]([cH:19][c:20]12)[Cl:21])[CH2:23][CH2:22][OH:24]|US20060052315A1_0276
3.9.12|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=C.[C&H3&D1:3]-[C&H0&+0&D3:2](-[C:1])=C>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[C&H0&+0&D3:2](-[C&H3&D1:3])-[C:1]|C=[C:1]([CH3:2])[CH2:3][C:4]([CH2:5][C:6](=C)[CH3:7])([C:8](=[O:9])[O:10][CH2:11][CH3:12])[C:13](=[O:14])[O:15][CH2:16][CH3:17]>ClC(Cl)([2H])[2H]>[CH3:2][C:1]1[CH2:3][C:4]([CH2:5][C:6]=1[CH3:7])([C:8](=[O:9])[O:10][CH2:11][CH3:12])[C:13](=[O:14])[O:15][CH2:16][CH3:17]|US10519115B2_0709
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[O&-]>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[Na+].[CH3:1][CH2:2][CH2:3][C:4]([O-])=[O:5].[CH3:6][C:7]1([O:8][c:9]2[cH:10][cH:11][cH:12][c:13]([c:14]2[O:15]1)[O:16][C:17](=[O:18])[NH:19][CH3:20])[CH3:21]>CCCC(=O)OC(=O)CCC.O=S(=O)(O)O>[CH3:6][C:7]1([O:8][c:9]2[cH:10][cH:11][cH:12][c:13]([c:14]2[O:15]1)[O:16][C:17](=[O:18])[N:19]([CH3:20])[C:4](=[O:5])[CH2:3][CH2:2][CH3:1])[CH3:21]|US20130289049A1_0159
7.6.1|[C&H3&D1:6]-[n&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1>>[C&H3&D1:6]-[N&H0&+0&D3:5]1-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1|[CH3:1][n:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21>O.[Na+].CC(=O)O.N#C[BH3-]>[CH3:1][N:2]1[CH2:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21|US20190343812A1_0645
1.7.12|[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C&H3&D1:4])-[O:3].[C:2]-[O&H1&+0&D1:1]>>[C&H3&+0&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[O&H0&+0&D2:1]-[C:2])-[O:3]|[CH3:1][C@H:2]([CH2:3][OH:4])[C@H:5]1[CH2:6][CH2:7][C@H:8]2[C@@H:9]3[CH:10]=[CH:11][C:12]4=[CH:13][C:14]([C@@H:15]5[O:16][C@@H:17]5[C@@:18]4([C@H:19]3[CH2:20][CH2:21][C@:22]12[CH3:23])[CH3:24])=[O:25].[CH2:26]=[C:27]([CH3:28])[O:29][CH3:30]>Cc1ccc(cc1)S(=O)(=O)O.Cc1ccccc1.CCN(CC)CC.c1ccncc1.O>[CH3:24][C@:18]12[C:12]([CH:11]=[CH:10][C@@H:9]3[C@@H:19]1[CH2:20][CH2:21][C@:22]1([C@H:8]3[CH2:7][CH2:6][C@@H:5]1[C@H:2]([CH3:1])[CH2:3][O:4][C:27]([CH3:28])([CH3:26])[O:29][CH3:30])[CH3:23])=[CH:13][C:14]([C@@H:15]1[O:16][C@@H:17]12)=[O:25]|US08207134B2_0627
3.1.2|[C&H2&D1:5]=[C&H1&+0&D2:4]-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[n:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H2&D1:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[c:11]([n:12][nH:13][c:14]2[C:15]1([CH3:16])[CH3:17])[NH:18][c:19]1[n:20][c:21]([n:22][cH:23][c:24]1[F:25])Cl.[CH2:26]=[CH:27]B1OC(C(O1)(C)C)(C)C>[CH]1[CH][CH][C]([CH]1)[PH+](c1ccccc1)c1ccccc1.[CH]1[CH][CH][C]([CH]1)[PH+](c1ccccc1)c1ccccc1.COCCOC.[O-]C([O-])=O.ClCCl.Cl[Pd]Cl.O.[Na+].[Na+].[Fe]>[CH2:26]=[CH:27][c:21]1[n:22][cH:23][c:24]([c:19]([n:20]1)[NH:18][c:11]1[n:12][nH:13][c:14]2[c:10]1[CH2:9][N:8]([C:15]2([CH3:16])[CH3:17])[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[F:25]|US20150099743A1_0248
2.2.3|[N&H2&+0&D1:6]-[c:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-F>>[N&H1&+0&D2:6](-[c:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|Cl.[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[C:38](=[O:39])[c:40]1[cH:41][c:42]([c:43]2[cH:44][cH:45][cH:46][cH:47][c:48]2[c:49]1[OH:50])[NH2:51].[NH2:52][C:53](=[O:54])[c:55]1[cH:56][c:57]([cH:58][c:59]([c:60]1[OH:61])[Cl:62])[N:63]=[N:64][c:65]1[cH:66][cH:67][c:68]([cH:69][cH:70]1)[S:71](=[O:72])(=[O:73])F>CS(C)=O.O=C(O[Na])O[Na]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[C:38](=[O:39])[c:40]1[cH:41][c:42]([c:43]2[cH:44][cH:45][cH:46][cH:47][c:48]2[c:49]1[OH:50])[NH:51][S:71](=[O:72])(=[O:73])[c:68]1[cH:69][cH:70][c:65]([cH:66][cH:67]1)[N:64]=[N:63][c:57]1[cH:56][c:55]([c:60]([c:59]([cH:58]1)[Cl:62])[OH:61])[C:53]([NH2:52])=[O:54]|EP1812389B1_0189
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O-][C:1](=[O:2])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][n:10]1[cH:11][n:12][c:13]2[cH:14][n:15][cH:16][cH:17][c:18]21.[CH3:19][NH:20][CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1.[K+]>[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1.CCN(CC)CC.CN(C)C=O>[CH3:19][N:20]([C:1](=[O:2])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][n:10]1[cH:11][n:12][c:13]2[cH:14][n:15][cH:16][cH:17][c:18]21)[CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1|US20120022045A1_0646
7.6.1|[C&H3&D1:6]-[c&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1>>[C&H3&D1:6]-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[c:3]:[c:2]-[N&H1&+0&D2:1]-1|[CH3:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7][cH:8][c:9]2[nH:10]1)[Cl:11]>[Na+].Cl[Al](Cl)Cl.c1ccncc1.[BH4-]>[CH3:1][CH:2]1[CH2:3][c:4]2[c:5]([cH:6][cH:7][cH:8][c:9]2[NH:10]1)[Cl:11]|EP2658844B1_0995
1.2.18|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H2&+0&D2:4]-[C:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:6]/[C&H0&+0&D3:5](-[N&H1&+0&D2:2]-[c:1])=[C&H1&+0&D2:4]/[C:3]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH2:8].[CH3:9][O:10][C:11](=[O:12])[CH2:13][C:14]([CH3:15])=O>>[CH3:9][O:10][C:11](=[O:12])/[CH:13]=[C:14](/[CH3:15])[NH:8][c:7]1[cH:6][cH:5][cH:4][cH:3][c:2]1[CH3:1]|EP2081903B1_0105
1.2.18|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H2&+0&D2:4]-[C:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[N&H1&+0&D2:2]-[c:1])=[C&H1&+0&D2:4]-[C:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]([CH3:8])=O.[NH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]=[C:7]([CH3:8])[NH:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US20100069360A1_0216
1.8.17|[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C&H3&D1:4])-[C:3].[C:2]-[S&H1&+0&D1:1]>>[C&H2&+0&D2:6](-[S&H0&+0&D2:1]-[C:2])-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C:3]|[CH2:1]=[C:2]([CH3:3])[C:4](=[O:5])[O:6][CH3:7].[CH3:8][O:9][C:10](=[O:11])[CH2:12][SH:13]>C=CC([O-])=O.C1CCNCC1>[CH3:8][O:9][C:10](=[O:11])[CH2:12][S:13][CH2:1][CH:2]([CH3:3])[C:4](=[O:5])[O:6][CH3:7]|US05510378A
7.6.1|[C:7]-[c&H0&+0&D3:6]1:[n&H1&+0&D2:5]:[c:4]:[c:3]:[c&H0&+0&D3:2]:1-[C:1]>>[C:7]-[C&H1&+0&D3:6]1-[N&H1&+0&D2:5]-[c:4]:[c:3]-[C&H1&+0&D3:2]-1-[C:1]|Cl.[CH3:1][c:2]1[cH:3][cH:4][c:5]2[nH:6][c:7]3[CH2:8][CH2:9][NH:10][CH2:11][c:12]3[c:13]2[cH:14]1>O.F[B-](F)(F)F.[H+].[O-2].[O-2].[Pt+4]>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[NH:6][CH:7]3[CH2:8][CH2:9][NH:10][CH2:11][CH:12]3[c:13]2[cH:14]1|US09063126B2_0806
3.1.2|[c:6]:[c&H0&+0&D3:5](:[c:4])-B1-O-C(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C@@H:2]1[CH2:3][N:4]([C@H:5]([CH2:6][N:7]1[CH:8]1[CH2:9][O:10][CH2:11]1)[CH3:12])[c:13]1[cH:14][cH:15][c:16]([n:17][cH:18]1)[NH:19][c:20]1[cH:21][c:22]([cH:23][n:24]([c:25]1=[O:26])[CH3:27])B1OC(C(O1)(C)C)C.[CH3:28][C:29]([CH3:30])([CH3:31])[c:32]1[cH:33][c:34]2[cH:35][n:36][n:37]([c:38]([c:39]2[c:40]([cH:41]1)[F:42])=[O:43])-[c:44]1[n:45][cH:46][cH:47][c:48]([c:49]1[CH:50]=[O:51])Cl>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.[O-]P([O-])([O-])=O.CC#N.Cl[Pd]Cl.[K+].[K+].[K+].[Fe+2]>[CH3:12][C@H:5]1[CH2:6][N:7]([C@@H:2]([CH2:3][N:4]1[c:13]1[cH:14][cH:15][c:16]([n:17][cH:18]1)[NH:19][c:20]1[cH:21][c:22]([cH:23][n:24]([c:25]1=[O:26])[CH3:27])-[c:48]1[cH:47][cH:46][n:45][c:44]([c:49]1[CH:50]=[O:51])-[n:37]1[n:36][cH:35][c:34]2[cH:33][c:32]([cH:41][c:40]([c:39]2[c:38]1=[O:43])[F:42])[C:29]([CH3:28])([CH3:30])[CH3:31])[CH3:1])[CH:8]1[CH2:9][O:10][CH2:11]1|US07935688B2_1178
1.2.18|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H2&+0&D2:4]-[C:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]/[C&H0&+0&D3:5](-[N&H1&+0&D2:1]-[C:2])=[C&H1&+0&D2:4]/[C:3]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][C:6]([CH3:7])=O.[CH3:8][CH2:9][N:10]1[CH2:11][CH2:12][CH2:13][CH:14]1[CH2:15][NH2:16]>[O-]S([O-])(=O)=O.ClCCl.Cl[2H].[Mg+2]>[CH3:1][O:2][C:3](=[O:4])/[CH:5]=[C:6](/[CH3:7])[NH:16][CH2:15][CH:14]1[CH2:13][CH2:12][CH2:11][N:10]1[CH2:9][CH3:8]|US20140288040A1_1376
7.6.1|[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c:4]:[c:3]:[n&H0&+0&D3:2]:1-[C:1]>>[C:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[c:4]:[c:3]-[N&H0&+0&D3:2]-1-[C:1]|[ClH:1].[cH:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][c:8]3[CH2:9][NH:10][CH2:11][CH2:12][CH2:13][n:14]3[c:15]12>CC(=O)O.[O-]S([O-])(=O)=O.[Pd].[Ba+2]>[ClH:1].[cH:5]1[cH:4][cH:3][cH:2][c:15]2[c:6]1[CH2:7][CH:8]1[CH2:9][NH:10][CH2:11][CH2:12][CH2:13][N:14]21|US07208494B2_0714
2.1.2|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[O&-].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[Na+].Cl.[CH3:1][C:2]([O-])=[O:3].[Cl:4][c:5]1[c:6]([cH:7][cH:8][c:9]2[CH2:10][CH2:11][NH:12][CH2:13][c:14]12)[Cl:15]>N.O.CC(=O)OC(C)=O.CC(=O)O>[CH3:1][C:2](=[O:3])[N:12]1[CH2:11][CH2:10][c:9]2[cH:8][cH:7][c:6]([c:5]([c:14]2[CH2:13]1)[Cl:4])[Cl:15]|EP0244088A2_0074
7.5.1|[O&H0&+0&D1:7]=[c&H0&+0&D3:6]1:[c:5]:[c:4]:[o&H0&+0&D2:3]:[c:2]:[c:1]:1>>[O&H1&+0&D1:7]-[C&H1&+0&D3:6]1-[c:5]:[c:4]-[O&H0&+0&D2:3]-[c:2]:[c:1]-1|[O:1]=[c:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[o:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]12>CCO.O=C(O)c1ccccc1Oc1ccccc1.O=C(O[K])O[K].O=P(O)(O)O.Oc1ccccc1.I[Cu].[Na].[Cu].[Hg]>[OH:1][CH:2]1[c:15]2[cH:14][cH:13][cH:12][cH:11][c:10]2[O:9][c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]21|EP0473411A1_0035
1.7.12|[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C&H3&D1:4])-[C:3].[C:2]-[O&H1&+0&D1:1]>>[C&H3&+0&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[O&H0&+0&D2:1]-[C:2]|[CH2:1]=[C:2]([CH3:3])[CH2:4][CH:5]([CH2:6][OH:7])[CH:8]1[CH2:9][CH:10]=[C:11]([C:12]1([CH3:13])[CH3:14])[CH3:15]>CCCCCC.Cc1ccc(cc1)S(=O)(=O)O>[CH3:15][C:11]1=[CH:10][CH2:9][CH:8]([C:12]1([CH3:13])[CH3:14])[CH:5]1[CH2:4][C:2]([O:7][CH2:6]1)([CH3:3])[CH3:1]|US20200140411A1_0889
1.7.12|[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C&H3&D1:4])-[C:3].[O&H1&+0&D1:2]-[c:1]>>[C&H3&+0&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[O&H0&+0&D2:2]-[c:1]|[CH2:1]=[CH:2][CH2:3][c:4]1[c:5]([cH:6][c:7]([c:8]([c:9]1[OH:10])[CH2:11][C:12](=[CH2:13])[CH3:14])[CH3:15])[CH3:16]>CC[O+](CC)[B-](F)(F)F.O=C(O)O[Na].ClCCCl>[CH2:1]=[CH:2][CH2:3][c:4]1[c:5]([cH:6][c:7]([c:8]2[CH2:11][C:12]([O:10][c:9]12)([CH3:14])[CH3:13])[CH3:15])[CH3:16]|US20200270239A1_0411
7.6.1|[C&H3&D1:6]-[c&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[n&H1&+0&D2:3]:[c:2]:[c:1]:1>>[C&H3&D1:6]-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[N&H1&+0&D2:3]-[c:2]:[c:1]-1|[CH3:1][c:2]1[cH:3][nH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12>>[CH3:1][CH:2]1[CH2:3][NH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21|US20200239454A1_0376
4.1.45|[C:6]-[N&H1&+0&D2:5]-[c:4]:[c:3]-[N&H0&+&D3:2](-[O&-])=O.[C&H1&+0&D2:1](=O)-O>>[C:6]-[n&H0&+0&D3:5]1:[c&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c:3]:[c:4]:1|[O-][N+:1](=O)[c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[NH:8][C@@H:9]1[CH2:10][CH2:11][C@@H:12]([C@@H:13]1[OH:14])[OH:15])[Cl:16])[Cl:17].O=[CH:18]O>CO.CC(C)O.ClC(Cl)Cl.[H][H].[Ni]>[OH:15][C@H:12]1[CH2:11][CH2:10][C@H:9]([C@H:13]1[OH:14])[n:8]1[cH:18][n:1][c:2]2[cH:3][c:4]([c:5]([cH:6][c:7]21)[Cl:16])[Cl:17]|US20070197532A1_0978
1.2.18|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H2&+0&D2:4]-[C:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[N&H1&+0&D2:1]-[C:2])=[C&H1&+0&D2:4]-[C:3]|[Na+:1].[CH3:2][O:3][C:4](=[O:5])[CH2:6][C:7]([CH3:8])=O.[NH2:9][CH:10]([C:11]([O-:12])=[O:13])[c:14]1[cH:15][o:16][cH:17][cH:18]1>Cc1ccccc1>[Na+:1].[CH3:2][O:3][C:4](=[O:5])[CH:6]=[C:7]([CH3:8])[NH:9][CH:10]([C:11]([O-:12])=[O:13])[c:14]1[cH:18][cH:17][o:16][cH:15]1|US09050346B2_0659
4.1.45|[C:6]-[C&H0&+0&D3:5](-O)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H0&+&D3:1](-[O&-])=O>>[C:6]-[c&H0&+0&D3:5]1:[n&H1&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D2:1]:1|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[N+:8]([O-])=O)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.O=[C:15](O)[CH2:16][Cl:17]>CO.[Pd]>[Cl:17][CH2:16][c:15]1[n:8][c:7]2[c:6]([cH:5][cH:4][cH:3][c:2]2[nH:1]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|EP1888556B1_0146
2.2.4|[N&H2&+0&D1:6]-[c:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-O>>[N&H1&+0&D2:6](-[c:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][CH2:2][CH2:3][n:4]1[c:5]2[n:6][c:7]([n:8]([c:9]2[c:10]([n:11]([c:12]1=[O:13])[CH2:14][CH2:15][CH3:16])=[O:17])[CH3:18])/[CH:19]=[CH:20]/[c:21]1[cH:22][c:23]([c:24]([cH:25][c:26]1[S:27](=[O:28])(=[O:29])O)[O:30][CH3:31])[O:32][CH3:33].[NH2:34][c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1>>[CH3:1][CH2:2][CH2:3][n:4]1[c:12]([n:11]([c:10]([c:9]2[c:5]1[n:6][c:7]([n:8]2[CH3:18])/[CH:19]=[CH:20]/[c:21]1[cH:22][c:23]([c:24]([cH:25][c:26]1[S:27](=[O:28])(=[O:29])[NH:34][c:35]1[cH:40][cH:39][cH:38][cH:37][cH:36]1)[O:30][CH3:31])[O:32][CH3:33])=[O:17])[CH2:14][CH2:15][CH3:16])=[O:13]|US09776995B2_1220
3.11.86|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C:5])-[C:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[C:8](=[O:9])[O:10][CH2:11][CH3:12].Cl[c:13]1[cH:14][n:15][c:16]([cH:17][n:18]1)-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>O.CCCCCC.CN(C)C=O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([C:8](=[O:9])[O:10][CH2:11][CH3:12])[c:13]1[cH:14][n:15][c:16]([cH:17][n:18]1)-[c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1|US20200316065A1_1857
3.11.86|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C:5])-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]([CH:3]=[C:4]1[CH2:5][CH2:6][CH:7]([C:8]1=[O:9])[CH3:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[CH3:17][C:18]([CH3:19])([CH3:20])[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)Br>c1ccc(cc1)P(c1ccccc1)c1ccc2ccccc2c1-c1c2ccccc2ccc1P(c1ccccc1)c1ccccc1.CC(=O)O[Pd]OC(C)=O.Cc1ccccc1.CC(C)(C)[O-].[Na+]>[CH3:17][C:18]([CH3:19])([CH3:20])[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[C:7]1([CH2:6][CH2:5][C:4]([C:8]1=[O:9])=[CH:3][N:2]([CH3:1])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[CH3:10]|US06867310B1_00393
1.2.14|[C:7]-[C&H1&+0&D3:6]1-[C:5]-[O&H0&+0&D2:4]-1.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[C&H1&+0&D3:6](-[C:5]-[O&H1&+0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]1([NH:3][C:4]([NH:5][C:6]1=[O:7])=[O:8])[CH3:9].[CH2:10]1[CH2:11][CH2:12][CH:13]2[O:14][CH:15]2[CH2:16]1>CC(C)=O.CN(C)C=O.Cl[Li]>[CH3:1][C:2]1([NH:3][C:4]([N:5]([C:6]1=[O:7])[CH:15]1[CH2:16][CH2:10][CH2:11][CH2:12][CH:13]1[OH:14])=[O:8])[CH3:9]|US09452998B2_0597
9.7.262|[C&H0&-&D1:6]#[N&H0&D1:5].[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H0&+0&D2:6](#[N&H0&D1:5])-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[C-:1]#[N:2].[CH3:3][O:4][c:5]1[cH:6][cH:7][cH:8][c:9]2[C:10]([c:11]3[c:12]([C:13]([c:14]12)=[O:15])[c:16]([c:17]1[CH2:18][CH2:19][C:20]([CH2:21][c:22]1[c:23]3[OH:24])=[O:25])[OH:26])=[O:27].[K+]>O.CCO.CC(=O)O.ClC(Cl)Cl>[CH3:3][O:4][c:5]1[cH:6][cH:7][cH:8][c:9]2[C:10]([c:11]3[c:12]([C:13]([c:14]12)=[O:15])[c:16]([c:17]1[CH2:18][CH2:19][C:20]([CH2:21][c:22]1[c:23]3[OH:24])([OH:25])[C:1]#[N:2])[OH:26])=[O:27]|EP2195290B1_0280
2.2.3|[N&H2&+0&D1:6]-[c:5].[N:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[N&H1&+0&D2:6](-[c:5])-[S&H0&+0&D4:3](-[N:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][n:9][c:10]1[NH2:11].[CH3:12][CH:13]([CH3:14])[NH:15][S:16](=[O:17])(=[O:18])Cl>c1ccccc1>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][n:9][c:10]1[NH:11][S:16](=[O:17])(=[O:18])[NH:15][CH:13]([CH3:12])[CH3:14]|US20200385354A1_0435
4.3.7|[N&H2&+0&D1:6]-[c:5]:[c:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[n&H0&+0&D2:6]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](-[N&H2&D1:2]):[c:4]:[c:5]:1|[CH3:1][S:2][c:3]1[n:4][c:5]([c:6]([s:7]1)[C:8]([NH2:9])=[S:10])[NH2:11]>O=S(=O)(O)O.BrBr>[CH3:1][S:2][c:3]1[n:4][c:5]2[n:11][s:10][c:8]([c:6]2[s:7]1)[NH2:9]|US07795255B2_0839
1.2.14|[C:7]-[N&H1&+0&D2:6]-[C:5].[c:4]-[C&H1&+0&D3:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H1&+0&D3:3](-[c:4])-[C:2]-[O&H1&+0&D1:1]|[CH3:1][C:2]1([O:3][c:4]2[cH:5][c:6]3[n:7][o:8][n:9][c:10]3[cH:11][c:12]2[CH:13]2[O:14][CH:15]21)[CH3:16].[CH2:17]1[CH2:18][CH2:19][NH:20][CH2:21]1>CCO>[CH3:1][C:2]1([O:3][c:4]2[cH:5][c:6]3[n:7][o:8][n:9][c:10]3[cH:11][c:12]2[CH:13]([CH:15]1[OH:14])[N:20]1[CH2:19][CH2:18][CH2:17][CH2:21]1)[CH3:16]|US06437171B1
1.8.4|[O&H0&-&D1:6]-[S&H0&+0&D3:5](=[O&H0&D1:4])-[c:3].[c:2]-[C&H2&+0&D2:1]-I>>[O&H0&+0&D1:6]=[S&H0&+0&D4:5](=[O&H0&D1:4])(-[c:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C@H:2]1[CH2:3][O:4][CH2:5][CH2:6][N:7]1[c:8]1[cH:9][c:10]([n:11][c:12]([n:13]1)[Cl:14])[CH2:15]I.[O-:16][S:17](=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[C:25]([F:26])([F:27])[F:28].[Na+]>CC#N>[CH3:1][C@H:2]1[CH2:3][O:4][CH2:5][CH2:6][N:7]1[c:8]1[cH:9][c:10]([n:11][c:12]([n:13]1)[Cl:14])[CH2:15][S:17](=[O:16])(=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[C:25]([F:26])([F:27])[F:28]|US20090018134A1_5677
3.11.52|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[c:4])-Br.[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[c:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]([CH3:6])(Br)[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.[N:13]#[C:14][CH2:15][C:16]#[N:17]>CC(C)(C)[O-].CO.O=C=O.C1CCOC1.[K+]>[CH3:1][O:2][C:3](=[O:4])[C:5]([CH3:6])([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[CH:15]([C:16]#[N:17])[C:14]#[N:13]|US10030027B2_0870
2.8.3|[C:7]-[N&H1&+0&D2:6]-[C:5].[O&H0&D1:4]=[P&H0&+0&D4:3](-[O:2])(-[O:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[P&H0&+0&D4:3](=[O&H0&D1:4])(-[O:2])-[O:1]|[O:1]=[C:2]([NH:3][C@H:4]1[CH2:5][NH:6][C:7]1=[O:8])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[CH3:17][O:18][P:19](=[O:20])(Cl)[O:21][CH3:22]>C[Si](C)(C)N(C(=O)C(F)(F)F)[Si](C)(C)C.ClC(Cl)(Cl)Cl>[CH3:17][O:18][P:19](=[O:20])([O:21][CH3:22])[N:6]1[CH2:5][C@@H:4]([C:7]1=[O:8])[NH:3][C:2](=[O:1])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US10508109B2_0379
3.11.33|[C&H2&+0&D1:7]=[C&H0&+0&D3:6](-[C:5])-[C:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H2&+0&D2:7]1-[c&H0&+0&D3:2](:[c:1]):[c:3]-[C:4]-[C&H1&+0&D3:6]-1-[C:5]|[CH2:1]=[C:2]([CH2:3][CH2:4][CH2:5][CH2:6][Cl:7])[C:8](=[O:9])[c:10]1[cH:11][cH:12][c:13]([c:14]([c:15]1[Cl:16])[Cl:17])[O:18][CH3:19]>O.Cl.C=O.CC(=O)O.COc1ccc(c(c1Cl)Cl)C(=O)CCCCCBr.CNC.CN(C)C=O.O=S(=O)(O)O>[CH3:19][O:18][c:13]1[cH:12][c:11]2[CH2:1][CH:2]([C:8]([c:10]2[c:15]([c:14]1[Cl:17])[Cl:16])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][Cl:7]|US04731471A
1.9.11|[O&H0&D1:7]=[P&H1&+0&D3:6](-[O:5])-[O:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O&H0&D1:7]=[P&H0&+0&D4:6](-[O:5])(-[O:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)Br.[CH3:12][CH2:13][O:14][PH:15](=[O:16])[O:17][CH2:18][CH3:19]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCN(CC)CC.CCOC(C)=O>[CH3:1][C:2](=[O:3])[O:4][CH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[P:15](=[O:16])([O:14][CH2:13][CH3:12])[O:17][CH2:18][CH3:19]|US20200115353A1_0593
2.2.3|[N&H2&+0&D1:6]-[c:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[N&H1&+0&D2:6](-[c:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])Cl.[NH2:11][c:12]1[cH:13][cH:14][cH:15][c:16]2[c:17]([cH:18][cH:19][cH:20][c:21]21)[OH:22]>c1ccncc1>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][c:12]1[cH:13][cH:14][cH:15][c:16]2[c:17]([cH:18][cH:19][cH:20][c:21]21)[OH:22]|US07417066B2_0191
3.11.86|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C:5])-[S:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[S:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C@H:2]([NH:3][C:4]1=[N:5][C:6]([CH:7]([S:8]1)[CH3:9])=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[C:17]([F:18])([F:19])[F:20].[N:21]#[C:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)Br>O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.C[Si](C)(C)N([Si](C)(C)C)[Li].Cc1ccccc1.[Pd].[Pd]>[CH3:1][C@H:2]([NH:3][C:4]1=[N:5][C:6]([C:7]([S:8]1)([CH3:9])[c:26]1[cH:25][cH:24][c:23]([cH:28][cH:27]1)[C:22]#[N:21])=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[C:17]([F:18])([F:19])[F:20]|EP1951695B1_0075
2.8.3|[C:6]-[N&H2&+0&D1:5].[Cl&H0&D1:4]-[P&H0&+0&D4:3](=[O&H0&D1:2])(-[O:1])-Cl>>[C:6]-[N&H1&+0&D2:5]-[P&H0&+0&D4:3](-[Cl&H0&D1:4])(=[O&H0&D1:2])-[O:1]|[O:1]=[P:2]([Cl:3])(Cl)[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Br:11].[CH3:12][O:13][C:14](=[O:15])[CH:16]([CH3:17])[NH2:18]>CCN(CC)CC.ClCCl>[CH3:12][O:13][C:14](=[O:15])[CH:16]([CH3:17])[NH:18][P:2](=[O:1])([Cl:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Br:11]|US20200339615A1_0127
4.2.17|[C:6]-[C&H0&+0&D4:5](-O-C)(-O-C)-O-C.[N&H2&+0&D1:4]-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[o&H0&+0&D2:1]:1|CO[C:1](OC)(OC)[C:2](=[O:3])[O:4][CH3:5].[NH2:6][c:7]1[cH:8][c:9]([c:10]2[cH:11][cH:12][cH:13][n:14][c:15]2[c:16]1[OH:17])[Cl:18]>>[CH3:5][O:4][C:2](=[O:3])[c:1]1[n:6][c:7]2[cH:8][c:9]([c:10]3[cH:11][cH:12][cH:13][n:14][c:15]3[c:16]2[o:17]1)[Cl:18]|EP1932837A1_0285
1.2.14|[C:7]-[C&H1&+0&D3:6]1-[C:5]-[O&H0&+0&D2:4]-1.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:7]-[C&H1&+0&D3:6](-[C:5]-[O&H1&+0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[cH:1]1[n:2][cH:3][nH:4][n:5]1.[CH2:6]1[CH2:7][CH2:8][CH:9]2[O:10][CH:11]2[CH2:12][CH2:13]1>CCCO.C1=CCCCCC1>[OH:10][CH:11]1[CH2:12][CH2:13][CH2:6][CH2:7][CH2:8][CH:9]1[n:4]1[cH:3][n:2][cH:1][n:5]1|US20200317637A1_0735
4.1.45|[N&H2&+0&D1:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[O:2]-[C&H0&+0&D4:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:6]1:[c:5]:[c:4]:[n&H1&+0&D2:3]:[c&H0&+0&D3:1]:1-[O:2]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH2:8])[CH:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[n:16]1[cH:17][n:18][cH:19][cH:20]1.CO[C:21]([O:22][CH3:23])(OC)OC>CC(=O)O.ClCCl>[CH3:23][O:22][c:21]1[n:8][c:7]2[cH:6][c:5]([cH:4][cH:3][c:2]2[nH:1]1)[CH:9]([c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1)[n:16]1[cH:20][cH:19][n:18][cH:17]1|US09458145B2_0656
4.1.45|[C:6]-[N&H1&+0&D2:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[C:6]-[n&H0&+0&D3:5]1:[c:4]:[c:3]:[n&H0&+0&D2:2]:[c&H1&+0&D2:1]:1|[CH3:1][O:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1[NH2:12])[CH2:13][N:14]1[CH2:15][CH2:16][N:17]([CH2:18][CH2:19]1)[CH:20]([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1.CO[CH:33](OC)OC>CC(=O)O>[CH3:1][O:2][CH2:3][CH2:4][n:5]1[cH:33][n:12][c:11]2[cH:10][c:9]([cH:8][cH:7][c:6]21)[CH2:13][N:14]1[CH2:15][CH2:16][N:17]([CH2:18][CH2:19]1)[CH:20]([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1|EP3313397B1_0192
2.2.3|[N&H2&+0&D1:6]-[O:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[N&H1&+0&D2:6](-[O:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][O:2][NH2:3].[O:4]=[S:5](=[O:6])(Cl)[c:7]1[cH:8][c:9]([c:10]([cH:11][c:12]1[Cl:13])[Cl:14])[Cl:15]>O.CCOCC.O[Na].C1CCOC1>[CH3:1][O:2][NH:3][S:5](=[O:4])(=[O:6])[c:7]1[cH:8][c:9]([c:10]([cH:11][c:12]1[Cl:13])[Cl:14])[Cl:15]|EP3597653A1_0244
2.2.3|[N&H2&+0&D1:6]-[N:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[N&H1&+0&D2:6](-[N:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[c:6]([n:7][c:8]([c:9]([c:10]1[CH3:11])[C:12](=[O:13])[NH:14][NH2:15])[NH2:16])[CH3:17].[O:18]=[S:19](=[O:20])(Cl)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>O[Na]>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[c:6]([n:7][c:8]([c:9]([c:10]1[CH3:11])[C:12](=[O:13])[NH:14][NH:15][S:19](=[O:18])(=[O:20])[c:21]1[cH:26][cH:25][cH:24][cH:23][cH:22]1)[NH2:16])[CH3:17]|US07718688B2_0213
3.11.93|[C:7]-[C&H1&+0&D3:6](-[C:5])-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:7][C:8]2([CH:9]([CH2:10][CH:11]1[N:12]([CH:13]2[CH3:14])[CH3:15])[CH3:16])[CH3:17].[CH3:18][CH2:19][O:20][C:21](=[O:22])Cl>CC(C)NC(C)C.CCCC[Li].C1CCOC1.[NH4+].[Cl-]>[CH3:15][N:12]1[CH:13]([C:8]2([CH2:7][C:6]([CH:11]1[CH2:10][CH:9]2[CH3:16])([C:21](=[O:22])[O:20][CH2:19][CH3:18])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[CH3:17])[CH3:14]|EP2913333A1_0133
4.1.94|[N&H2&+0&D1:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[S&H0&D1:2]=[C&H0&+0&D2:1]=S>>[n&H1&+0&D2:6]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:3]:[c:4]:[c:5]:1)=[S&H0&D1:2]|[NH2:1][c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[NH2:8])[I:9])[Cl:10].[S:11]=[C:12]=S>O.CCO.[OH-].[K+]>[S:11]=[c:12]1[nH:8][c:7]2[cH:6][c:5]([c:4]([cH:3][c:2]2[nH:1]1)[Cl:10])[I:9]|US20170275279A1_0317
4.2.9|[C&H3&+0&D1:5]-[S&+](-C)-C.[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H2&+0&D2:5]1-[O&H0&+0&D2:2]-[C&H0&+0&D4:3]-1(-[C&H3&D1:4])-[c:1]|[I-].[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[F:10].C[S+](C)[CH3:11]>O.CS(C)=O.[NaH]>[CH3:1][C:2]1([CH2:11][O:3]1)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[F:10]|US20090018123A1_0812
1.8.2|[O&H0&-&D1:6]-[S&H0&+0&D3:5](=[O&H0&D1:4])-[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D1:6]=[S&H0&+0&D4:5](=[O&H0&D1:4])(-[c:3])-[C&H2&+0&D2:1]-[c:2]|[Na+].[O-:1][S:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.Cl[CH2:10][c:11]1[cH:12][cH:13][cH:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]12>O.CN(C)C=O>[O:1]=[S:2](=[O:3])([CH2:10][c:11]1[cH:12][cH:13][cH:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21)[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1|US09862713B2_0429
3.11.1|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[C:3]-[C&H2&+0&D2:2]-[C:1]>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH2:1]=[CH:2][CH2:3][CH:4]1[CH2:5][C:6]([N:7]1[C:8]([C:9](=[O:10])[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)=[P:19]([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)=[O:38].[O:39]=[C:40]1[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]1>CC(C)NC1CCCCC1.CCCCCC.CCCC[Li].C1CCOC1.CC(=O)O>[CH2:1]=[CH:2][CH2:3][CH:4]1[CH:5]([C:6]([N:7]1[C:8]([C:9](=[O:10])[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)=[P:19]([c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)=[O:38])[C:40]1([CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1)[OH:39]|US20020198207A1_0554
4.1.5|[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](-[c:4])=O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[C@@H:11]1[CH2:12][N:13]([CH2:14][CH2:15][C@@H:16]1[NH:17][C:18](=O)[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[CH3:25]>O=P(Cl)(Cl)Cl>[CH3:10][O:9][c:8]1[cH:7][c:6]2[C:18](=[N:17][C@H:16]3[CH2:15][CH2:14][N:13]([CH2:12][C@H:11]3[c:5]2[cH:4][c:3]1[O:2][CH3:1])[CH3:25])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|EP2721036B1_0167
1.6.8|[c:7]:[c&H0&+0&D3:6](:[c:5])-I.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[c:7]:[c&H0&+0&D3:6](:[c:5])-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1I.[cH:10]1[cH:11][nH:12][n:13][n:14]1>CN[C@@H]1CCCC[C@H]1NC.CCOC(C)=O.CN(C)C=O.[O-]C([O-])=O.I[Cu].[Cs+].[Cs+]>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1-[n:13]1[n:14][cH:10][cH:11][n:12]1|US10131653B2_1777
1.2.18|[C:7]-[N&H1&+0&D2:6]-[C:5].[C:4]-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[c:1])=O>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:2](-[c:1])=[C&H1&+0&D2:3]-[C:4]|O=[C:1]1[CH2:2][CH2:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12.[CH2:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH:2]1[CH2:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[C:1]=1[N:14]1[CH2:15][CH2:16][CH2:11][CH2:12][CH2:13]1|US20060166984A1_0109
2.5.7|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D3:4](-[N:3])-S-C.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](=[N&H0&+0&D2:1]-[C:2])-[N:3]|[IH:1].[CH3:2][N:3]=[C:4]([NH:5][CH3:6])SC.[NH2:7][CH2:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>CCO.CS>[IH:1].[CH3:2][NH:3][C:4](=[N:7][CH2:8][CH2:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1)[NH:5][CH3:6]|US04287198A
1.2.18|[C:7]-[N&H1&+0&D2:6]-[C:5].[c:4]-[C&H0&+0&D3:3](-[C&H2&+0&D2:2]-[c:1])=O>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:3](-[c:4])=[C&H1&+0&D2:2]-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[S:6][c:7]3[cH:8][cH:9][c:10]([cH:11][c:12]3[C:13]([CH2:14][c:15]2[cH:16]1)=O)[F:17].[CH3:18][N:19]1[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1>c1ccccc1.O=C(O)O[Na].Cl[Ti](Cl)(Cl)Cl.O>[CH3:18][N:19]1[CH2:20][CH2:21][N:22]([CH2:23][CH2:24]1)[C:13]1=[CH:14][c:15]2[cH:16][c:2]([cH:3][cH:4][c:5]2[S:6][c:7]2[cH:8][cH:9][c:10]([cH:11][c:12]12)[F:17])[CH3:1]|US05700445A
3.11.39|[C&H1&+0&D1:6]#[C&H1&D1:5].[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H0&+0&D2:6](#[C&H1&D1:5])-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH:1]#[CH:2].[O:3]=[C:4]1[CH2:5][CH2:6][c:7]2[c:8]([CH2:9]1)[c:10]([c:11]1[C:12]([c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3[C:19]([c:20]1[c:21]2[OH:22])=[O:23])=[O:24])[OH:25]>CC[Mg]Br.O=C(O)C(=O)O.C1CCOC1>[CH:2]#[C:1][C:4]1([CH2:5][CH2:6][c:7]2[c:21]([c:20]3[C:19]([c:18]4[cH:17][cH:16][cH:15][cH:14][c:13]4[C:12]([c:11]3[c:10]([c:8]2[CH2:9]1)[OH:25])=[O:24])=[O:23])[OH:22])[OH:3]|US05116830A
1.2.2|[C:6]-[S&H0&+0&D3:5](-[N&H2&+0&D1:4])=[O&H0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:6]-[S@@&H0&+0&D3:5](-[N&H0&+0&D2:4]=[C&H1&+0&D2:1]-[c:2])=[O&H0&D1:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[S:5]([NH2:6])=[O:7].O=[CH:8][c:9]1[cH:10][cH:11][s:12][cH:13]1>C1CCNC1.ClCCl>[CH3:1][C:2]([CH3:3])([CH3:4])[S@@:5](=[O:7])[N:6]=[CH:8][c:9]1[cH:10][cH:11][s:12][cH:13]1|US20200377512A1_0199
1.8.2|[C:6]-[C&H2&+0&D2:5]-Cl.[O&H0&-&D1:4]-[S&H0&+0&D3:3](=[O&H0&D1:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&+0&D1:4])(=[O&H0&D1:2])-[c:1]|[Na+].[CH3:1][C:2](=[O:3])[O:4][CH2:5][CH:6]=[C:7]([CH3:8])[CH2:9]Cl.[O-:10][S:11](=[O:12])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>CN(C)C=O>[CH3:1][C:2](=[O:3])[O:4][CH2:5][CH:6]=[C:7]([CH3:8])[CH2:9][S:11](=[O:10])(=[O:12])[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|EP0853634B1_0060
1.8.1|[C:6]-[C&H2&+0&D2:5]-Br.[O&H0&-&D1:4]-[S&H0&+0&D3:3](=[O&H0&D1:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&+0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8]([O-:9])=[O:10].[CH3:11][Sn:12]([CH3:13])([CH3:14])[CH2:15][CH2:16][CH2:17][CH2:18]Br.[Na+]>CCCCCCCCCCCCCCCC[P+](CCCC)(CCCC)CCCC.Cc1ccccc1.O.[Br-]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:10])(=[O:9])[CH2:18][CH2:17][CH2:16][CH2:15][Sn:12]([CH3:11])([CH3:13])[CH3:14]|US20070037807A1_1414
1.2.17|[C&H2&+0&D1:7]=[C&H0&+0&D3:6](-[C:5])-[C:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:7](-[N&H0&+0&D3:2](-[C:3])-[C:1])-[C&H1&+0&D3:6](-[C:5])-[C:4]|[CH2:1]=[C:2]([C:3]#[N:4])[CH2:5][N:6]([CH3:7])[CH3:8].[OH:9][CH:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1>c1ccccc1.CO>[CH3:7][N:6]([CH3:8])[CH2:5][CH:2]([C:3]#[N:4])[CH2:1][N:13]1[CH2:12][CH2:11][CH:10]([CH2:15][CH2:14]1)[OH:9]|US20140315889A1_0742
3.11.76|[C:7]-[C&H2&+0&D2:6]-[C:5].[N&+:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C:7]-[C&H1&+0&D3:6](-[C:5])-[C&H1&+0&D3:2](-[c:1])-[C&H2&+0&D2:3]-[N&+:4]|[CH3:1][CH:2]=[CH:3][CH2:4][CH2:5][C:6](=[O:7])[CH2:8][C:9](=[O:10])[O:11][CH3:12].[O-:13][N+:14](=[O:15])[CH:16]=[CH:17][c:18]1[cH:19][cH:20][c:21]2[O:22][CH2:23][O:24][c:25]2[cH:26]1>CCCCCC.CCOC(C)=O.CC(C)O.C1CCOC1.C1CN=C2CCCCCN2C1>[CH3:1][CH:2]=[CH:3][CH2:4][CH2:5][C:6](=[O:7])[CH:8]([C:9](=[O:10])[O:11][CH3:12])[CH:17]([CH2:16][N+:14]([O-:13])=[O:15])[c:18]1[cH:19][cH:20][c:21]2[O:22][CH2:23][O:24][c:25]2[cH:26]1|US09206090B2_0352
1.2.18|[C:7]-[N&H1&+0&D2:6]-[C:5].[C:4]-[C&H0&+0&D3:3](-[C&H2&+0&D2:2]-[c:1])=O>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:3](-[C:4])=[C&H1&+0&D2:2]-[c:1]|O=[C:1]1[CH2:2][CH2:3][c:4]2[cH:5][c:6]3[O:7][CH2:8][O:9][c:10]3[cH:11][c:12]2[CH2:13]1.[cH:14]1[cH:15][n:16][c:17]([n:18][cH:19]1)[N:20]1[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]1>Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH:13]1=[C:1]([CH2:2][CH2:3][c:4]2[cH:5][c:6]3[O:7][CH2:8][O:9][c:10]3[cH:11][c:12]12)[N:23]1[CH2:24][CH2:25][N:20]([CH2:21][CH2:22]1)[c:17]1[n:18][cH:19][cH:14][cH:15][n:16]1|US09296750B2_0768
1.6.8|[c:7]:[c&H0&+0&D3:6](:[c:5])-I.[c:4]:[n&H0&+0&D2:3]:[n&H1&+0&D2:2]:[c:1]>>[c:7]:[c&H0&+0&D3:6](:[c:5])-[n&H0&+0&D3:3](:[c:4]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][C@@H:2]1[CH2:3][CH2:4][CH2:5][C@@H:6]([c:7]2[cH:8][c:9]([cH:10][cH:11][n:12]2)-[c:13]2[nH:14][n:15][cH:16][c:17]2[NH:18][C:19]1=[O:20])[n:21]1[cH:22][n:23][c:24]([cH:25][c:26]1=[O:27])-[c:28]1[cH:29][c:30]([cH:31][cH:32][c:33]1-[n:34]1[cH:35][c:36]([n:37][n:38]1)[C:39]([F:40])([F:41])[F:42])[Cl:43].[CH3:44][O:45][c:46]1[cH:47][c:48]([c:49]([cH:50][n:51]1)[F:52])I>>[CH3:44][O:45][c:46]1[cH:47][c:48]([c:49]([cH:50][n:51]1)[F:52])-[n:15]1[cH:16][c:17]2[NH:18][C:19]([C@@H:2]([CH2:3][CH2:4][CH2:5][C@@H:6]([c:7]3[cH:8][c:9](-[c:13]2[n:14]1)[cH:10][cH:11][n:12]3)[n:21]1[cH:22][n:23][c:24]([cH:25][c:26]1=[O:27])-[c:28]1[cH:29][c:30]([cH:31][cH:32][c:33]1-[n:34]1[cH:35][c:36]([n:37][n:38]1)[C:39]([F:40])([F:41])[F:42])[Cl:43])[CH3:1])=[O:20]|US09926282B2_1347
1.2.16|[C&H2&+0&D1:7]=[C&H0&+0&D3:6](-[C:5])-[N:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H2&+0&D2:7](-[n&H0&+0&D3:2](:[c:3]):[c:1])-[C&H1&+0&D3:6](-[C:5])-[N:4]|[CH2:1]=[C:2]([C:3](=[O:4])[O:5][CH3:6])[N:7]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21].[O:22]=[c:23]1[cH:24][c:25]([cH:26][cH:27][nH:28]1)[O:29][CH2:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1>O=C(O[Cs])O[Cs].CC#N>[CH3:19][C:18]([CH3:20])([CH3:21])[O:17][C:15](=[O:16])[N:7]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH:2]([CH2:1][n:28]1[cH:27][cH:26][c:25]([cH:24][c:23]1=[O:22])[O:29][CH2:30][c:31]1[cH:36][cH:35][cH:34][cH:33][cH:32]1)[C:3](=[O:4])[O:5][CH3:6]|US10358463B2_0521
1.2.16|[C&H2&+0&D1:7]=[C&H0&+0&D3:6](-[C:5])-[c:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:7](-[N&H0&+0&D3:2](-[C:3])-[C:1])-[C&H1&+0&D3:6](-[C:5])-[c:4]|[CH2:1]=[C:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1.[CH3:12][O:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[N:20]1[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]1>CCO>[CH3:12][O:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[N:20]1[CH2:21][CH2:22][N:23]([CH2:24][CH2:25]1)[CH2:1][CH:2]([C:3](=[O:4])[OH:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1|US20040097518A1_0314
2.3.12|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-N(-C)-C>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][O:2][CH2:3][C:4]1([CH:5]=[C:6]([CH2:7][N:8]1[C:9](=[O:10])N(C)C)[c:11]1[cH:12][c:13]([cH:14][cH:15][c:16]1[F:17])[F:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[CH3:25][N:26]1[CH2:27][CH2:28][CH:29]([CH2:30][CH2:31]1)[NH:32][CH3:33]>O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.C1CCOC1>[CH3:1][O:2][CH2:3][C:4]1([CH:5]=[C:6]([CH2:7][N:8]1[C:9](=[O:10])[N:32]([CH3:33])[CH:29]1[CH2:28][CH2:27][N:26]([CH2:31][CH2:30]1)[CH3:25])[c:11]1[cH:12][c:13]([cH:14][cH:15][c:16]1[F:17])[F:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|US20100104659A1_1239
1.6.6|[c:7]:[c&H0&+0&D3:6](:[c:5])-F.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[c:7]:[c&H0&+0&D3:6](:[c:5])-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)F.[cH:10]1[n:11][n:12][n:13][nH:14]1>CN(C)C=O.O=C(O[K])O[K]>[O-:1][N+:2](=[O:3])[c:4]1[cH:9][cH:8][c:7]([cH:6][cH:5]1)-[n:13]1[n:14][cH:10][n:11][n:12]1|US20180170909A1_1526
1.8.1|[O&H0&-&D1:6]-[S&H0&+0&D3:5](=[O&H0&D1:4])-[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[O&H0&+0&D1:6]=[S&H0&+0&D4:5](=[O&H0&D1:4])(-[c:3])-[C&H2&+0&D2:1]-[c:2]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][c:7]([cH:8][cH:9][cH:10]1)[CH2:11]Br.[CH3:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[S:19]([O-:20])=[O:21].[Na+]>CN(C)C=O.O>[CH3:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[S:19](=[O:20])(=[O:21])[CH2:11][c:7]1[cH:8][cH:9][cH:10][c:5]([cH:6]1)[C:2]([F:1])([F:3])[F:4]|US07943639B2_0721
3.11.39|[C&H1&+0&D1:6]#[C:5].[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H0&+0&D2:6](#[C:5])-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[O&H1&+0&D1:1]|[CH:1]#[C:2][C:3](=[CH2:4])[CH3:5].[CH3:6][CH:7]([CH3:8])[CH2:9][C:10]([CH3:11])=[O:12]>Cc1ccccc1.O[K]>[CH2:4]=[C:3]([CH3:5])[C:2]#[C:1][C:10]([CH3:11])([OH:12])[CH2:9][CH:7]([CH3:6])[CH3:8]|EP3186239B1_0438
4.1.5|[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](-[C:4])=O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]([CH2:12][C:13](=O)[NH:14][CH2:15][CH2:16][c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[O:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[O:31][CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1)[c:39]1[cH:40][cH:41][c:42]([cH:43][cH:44]1)[Cl:45]>c1ccccc1.O=P(Cl)(Cl)Cl>[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]([CH2:12][C:13]1=[N:14][CH2:15][CH2:16][c:17]2[c:18]1[cH:19][c:20]([c:21]([cH:22]2)[O:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[O:31][CH2:32][c:33]1[cH:38][cH:37][cH:36][cH:35][cH:34]1)[c:39]1[cH:40][cH:41][c:42]([cH:43][cH:44]1)[Cl:45]|US20200299283A1_0763
3.11.60|[C&H2&+0&D1:5]=[N&+]=[N&-].[C:4]-[C&H0&+0&D3:3](-[Cl&H0&+0&D1:2])=[O&H0&D1:1]>>[C&H2&+0&D2:5](-[Cl&H0&+0&D1:2])-[C&H0&+0&D3:3](-[C:4])=[O&H0&D1:1]|[CH3:1][O:2][CH2:3][O:4][CH2:5][C:6](=[O:7])[Cl:8].[CH2:9]=[N+]=[N-]>CCN(CC)CC.CCOCC.O>[CH3:1][O:2][CH2:3][O:4][CH2:5][C:6](=[O:7])[CH2:9][Cl:8]|EP3018125A1_0498
1.8.1|[C:6]-[S&H0&+0&D3:5](-[O&H0&-&D1:4])=[O&H0&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C:6]-[S&H0&+0&D4:5](=[O&H0&+0&D1:4])(=[O&H0&D1:3])-[C&H2&+0&D2:1]-[c:2]|[F:1][c:2]1[c:3]([c:4]([c:5]([c:6]([c:7]1[F:8])-[c:9]1[c:10]([c:11]([c:12]([c:13]([c:14]1[F:15])[F:16])[F:17])[F:18])[F:19])[F:20])[F:21])[CH2:22]Br.[O-:23][S:24](=[O:25])[C:26]([F:27])([F:28])[F:29].[Na+]>CCOC(C)=O.CCC#N.O>[O:25]=[S:24](=[O:23])([CH2:22][c:3]1[c:4]([c:5]([c:6]([c:7]([c:2]1[F:1])[F:8])-[c:9]1[c:10]([c:11]([c:12]([c:13]([c:14]1[F:15])[F:16])[F:17])[F:18])[F:19])[F:20])[F:21])[C:26]([F:27])([F:28])[F:29]|US20190284192A1_1544
1.2.16|[C&H2&+0&D1:7]=[C&H0&+0&D3:6](-[C:5])-[N:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:7](-[N&H0&+0&D3:2](-[C:3])-[C:1])-[C&H1&+0&D3:6](-[C:5])-[N:4]|[CH2:1]=[C:2]1[C:3]([CH:4]2[CH2:5][CH2:6][N:7]1[CH2:8][CH2:9]2)=[O:10].[CH2:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1>CCCCCC>[O:10]=[C:3]1[CH:4]2[CH2:5][CH2:6][N:7]([CH2:8][CH2:9]2)[CH:2]1[CH2:1][N:14]1[CH2:15][CH2:16][CH2:11][CH2:12][CH2:13]1|US07220862B2_0677
10.2.1|[O&H0&-&D1:6]-[N&H0&+&D3:5](=[O&H0&D1:4])-[O&-].[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&-&D1:6]-[N&H0&+&D3:5](=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O-][N+:1]([O-:2])=[O:3].[O:4]=[C:5]([OH:6])[c:7]1[cH:8][cH:9][cH:10][c:11]2[c:12]1[nH:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[c:20]2=[O:21].[K+]>O.O=S(=O)(O)O>[O-:2][N+:1](=[O:3])[c:17]1[cH:16][cH:15][c:14]2[nH:13][c:12]3[c:11]([cH:10][cH:9][cH:8][c:7]3[C:5](=[O:4])[OH:6])[c:20]([c:19]2[cH:18]1)=[O:21]|US09663530B2_0274
3.11.31|[C&H3&D1:6]-[C&H2&+0&D2:5]-[N&+:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[N&+:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH:8]=[O:9].[CH3:10][CH2:11][N+:12]([O-:13])=[O:14]>O.O=S(O)O[Na].O[Na]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH:8]([OH:9])[CH:11]([CH3:10])[N+:12]([O-:13])=[O:14]|US20190233425A1_1135
1.2.18|[C:7]-[C&H2&+0&D2:6]-[C&H0&+0&D3:5](-[C:4])=O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[C&H1&+0&D2:6]=[C&H0&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|O=[C:1]1[CH2:2][CH2:3][S:4][CH2:5][CH2:6]1.[CH2:7]1[CH2:8][CH2:9][NH:10][CH2:11]1>c1ccccc1.O>[CH:6]1[CH2:5][S:4][CH2:3][CH2:2][C:1]=1[N:10]1[CH2:9][CH2:8][CH2:7][CH2:11]1|EP3541792B1_1258
3.11.31|[C&H3&D1:6]-[C&H2&+0&D2:5]-[N&+:4].[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[N&+:4])-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][N+:3]([O-:4])=[O:5].[CH3:6][CH2:7][CH:8]=[O:9]>>[CH3:1][CH:2]([CH:8]([OH:9])[CH2:7][CH3:6])[N+:3]([O-:4])=[O:5]|EP0310341A2_0020
1.2.2|[C:6]-[S@@&H0&+0&D3:5](-[N&H2&+0&D1:4])=[O&H0&D1:3].[c:2]-[C&H1&+0&D2:1]=O>>[C:6]-[S&H0&+0&D3:5](/[N&H0&+0&D2:4]=[C&H1&+0&D2:1]/[c:2])=[O&H0&D1:3]|O=[CH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[F:8])[Br:9].[CH3:10][C:11]([CH3:12])([CH3:13])[S@@:14]([NH2:15])=[O:16]>Cc1ccc(cc1)S(=O)(=O)O.c1ccncc1.[O-]S([O-])(=O)=O.ClCCl.[Mg+2]>[CH3:10][C:11]([CH3:12])([CH3:13])[S:14](=[O:16])/[N:15]=[CH:1]/[c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[F:8])[Br:9]|US20200206233A1_0363
3.11.39|[C&H1&+0&D1:6]#[C:5].[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H0&+0&D2:6](#[C:5])-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[O&H1&+0&D1:2])-[c:1]|[CH:1]#[C:2][CH2:3][N:4]([CH3:5])[CH3:6].[CH3:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Br:16]>NCCN.C1CCOC1.[Li]>[CH3:5][N:4]([CH3:6])[CH2:3][C:2]#[C:1][C:8]([CH3:7])([OH:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Br:16]|EP0401517A1_0037
3.9.68|[O&H0&+0&D1:7]=[C&H1&+0&D2:6]-[c:5].[S:4]-[C&H1&+0&D3:3](-[S:2])-[c:1]>>[O&H1&+0&D1:7]-[C&H1&+0&D3:6](-[c:5])-[C&H0&+0&D4:3](-[S:4])(-[S:2])-[c:1]|[CH3:1][N:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH:10]=[O:11].[OH:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[CH:19]1[S:20][CH2:21][CH2:22][CH2:23][S:24]1>C1CCOC1.[Li]>[CH3:1][N:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH:10]([OH:11])[C:19]1([S:24][CH2:23][CH2:22][CH2:21][S:20]1)[c:16]1[cH:15][cH:14][c:13]([cH:18][cH:17]1)[OH:12]|US20080293718A1_0738
1.6.6|[c:7]:[c&H0&+0&D3:6](:[c:5])-F.[c:4]:[n&H0&+0&D2:3]:[n&H1&+0&D2:2]:[c:1]>>[c:7]:[c&H0&+0&D3:6](:[c:5])-[n&H0&+0&D3:3](:[c:4]):[n&H0&+0&D2:2]:[c:1]|F[c:1]1[c:2]([cH:3][c:4]([cH:5][c:6]1[Cl:7])[C:8]([F:9])([F:10])[F:11])[Cl:12].[NH2:13][c:14]1[n:15][cH:16][nH:17][n:18]1>O=C(O[K])O[K].CN(C)C=O.O>[NH2:13][c:14]1[n:15][cH:16][n:17][n:18]1-[c:1]1[c:2]([cH:3][c:4]([cH:5][c:6]1[Cl:7])[C:8]([F:9])([F:10])[F:11])[Cl:12]|US20090275619A1_0852
3.11.92|[C&H2&+0&D1:7]=[C&H1&+0&D2:6]-[C:5].[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C&H2&+0&D2:7](-[C&H2&+0&D2:6]-[C:5])-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH3:1][CH:2]([CH3:3])[CH:4]1[CH2:5][c:6]2[cH:7][c:8]([c:9]([c:10]([c:11]2[C:12]1=[O:13])[Cl:14])[Cl:15])[O:16][CH2:17][C:18](=[O:19])[OH:20].[CH2:21]=[CH:22][C:23]([CH3:24])=[O:25]>c1ccccc1.CC(=O)O.CO.C[O-].[Na+]>[CH3:24][C:23](=[O:25])[CH2:22][CH2:21][C:4]1([CH2:5][c:6]2[cH:7][c:8]([c:9]([c:10]([c:11]2[C:12]1=[O:13])[Cl:14])[Cl:15])[O:16][CH2:17][C:18](=[O:19])[OH:20])[CH:2]([CH3:1])[CH3:3]|EP3699173A1_0422
3.11.1|[C&H2&+0&D1:6]=[O&H0&+0&D1:5].[C&H3&D1:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C&H2&+0&D2:6](-[O&H1&+0&D1:5])-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[C:1]|[CH3:1][CH:2]1[C:3]([N:4]2[CH:5]1[CH:6]([CH2:7][O:8][C:9]2([CH3:10])[CH3:11])[CH3:12])=[O:13].[CH2:14]=[O:15]>CC(C)N(C(C)C)[Li].C1CCOC1.Cl[Na].O>[CH3:12][CH:6]1[CH2:7][O:8][C:9]([N:4]2[C:3]([C:2]([CH:5]12)([CH3:1])[CH2:14][OH:15])=[O:13])([CH3:10])[CH3:11]|US09981894B2_0115
2.3.12|[C:6]-[N&H1&+0&D2:5]-[C:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-n1:c:[n&+](-C):c:c:1>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][C@H:10]1[CH2:11][N:12]([CH2:13][C@@H:14]1[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[C:21](=[O:22])n1cc[n+](c1)C)[C@H:23]([CH3:24])[c:25]1[cH:26][cH:27][cH:28][c:29]2[c:30]1[cH:31][cH:32][cH:33][cH:34]2.[CH3:35][CH2:36][O:37][C:38](=[O:39])[CH:40]1[CH2:41][CH2:42][NH:43][CH2:44][CH2:45]1.[I-]>CCN(CC)CC.CCOC(C)=O.ClCCl>[CH3:24][C@H:23]([c:25]1[cH:26][cH:27][cH:28][c:29]2[c:30]1[cH:31][cH:32][cH:33][cH:34]2)[N:8]([CH2:9][C@H:10]1[CH2:11][N:12]([CH2:13][C@@H:14]1[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[C:21](=[O:22])[N:43]1[CH2:42][CH2:41][CH:40]([CH2:45][CH2:44]1)[C:38](=[O:39])[O:37][CH2:36][CH3:35])[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20190177272A1_0596
10.1.5|[Br&H0&+0&D1:5]-N1-C(=O)-C-C-C-1=O.[F&H0&D1:4]-[C&H1&+0&D3:3](-[F&H0&D1:2])-[c:1]>>[Br&H0&+0&D1:5]-[C&H0&+0&D4:3](-[F&H0&D1:4])(-[F&H0&D1:2])-[c:1]|[F:1][CH:2]([F:3])[c:4]1[cH:5][cH:6][c:7]2[O:8][CH2:9][O:10][c:11]2[cH:12]1.O=C1CCC(N1[Br:13])=O>CC(C)(C#N)N=NC(C)(C)C#N.ClC(Cl)(Cl)Cl>[F:1][C:2]([F:3])([Br:13])[c:4]1[cH:5][cH:6][c:7]2[O:8][CH2:9][O:10][c:11]2[cH:12]1|US08455638B2_0342
4.1.16|[C&H3&D1:6]-[C&H0&+0&D3:5](-O)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1|[CH3:1][CH:2]([OH:3])[CH2:4][n:5]1[c:6]([c:7]([c:8]([n:9]([c:10]1=[O:11])[CH3:12])=[O:13])[NH2:14])[NH2:15].[CH3:16][C:17](=O)O>CCOCC.ClC(Cl)Cl>[CH3:1][CH:2]([OH:3])[CH2:4][n:5]1[c:10]([n:9]([c:8]([c:7]2[nH:14][c:17]([n:15][c:6]21)[CH3:16])=[O:13])[CH3:12])=[O:11]|US06075029A
4.2.8|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[C&H1&+0&D2:3]-[C:2].[O&H1&+0&D1:1]-O>>[C&H3&D1:6]-[C&H0&+0&D4:5]1(-[C:4])-[O&H0&+0&D2:1]-[C&H1&+0&D3:3]-1-[C:2]|[CH3:1][C:2]1([CH2:3][C:4]([CH:5]=[C:6]([C:7]1=[O:8])[CH3:9])=[O:10])[CH3:11].O[OH:12]>O.[Na+].CO.[OH-]>[CH3:1][C:2]1([CH2:3][C:4]([CH:5]2[O:12][C:6]2([C:7]1=[O:8])[CH3:9])=[O:10])[CH3:11]|US20060041123A1_1009
2.4.10|[N:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O-c1:c:c:c(:c:c:1)-[N&+](-[O&-])=O.[O&H1&+0&D1:2]-[c:1]>>[N:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][NH:3][C:4](=[O:5])[c:6]1[n:7][n:8][c:9]([n:10]1-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[C:17](=[O:18])[N:19]1[CH2:20][CH2:21][N:22]([CH2:23][CH2:24]1)[c:25]1[cH:26][c:27]([c:28]([c:29]([cH:30]1)[CH3:31])[OH:32])[CH3:33])-[c:34]1[cH:35][c:36]([c:37]([cH:38][c:39]1[OH:40])[OH:41])[CH:42]([CH3:43])[CH3:44].[O-][N+](=O)c1ccc(cc1)O[C:45](=[O:46])[NH:47][c:48]1[cH:49][cH:50][cH:51][c:52]2[c:53]1[CH2:54][N:55]([C:56]2=[O:57])[CH:58]1[CH2:59][CH2:60][C:61]([NH:62][C:63]1=[O:64])=[O:65]>CCN(C(C)C)C(C)C.CN(C)C=O>[CH3:1][CH2:2][NH:3][C:4](=[O:5])[c:6]1[n:7][n:8][c:9]([n:10]1-[c:11]1[cH:16][cH:15][c:14]([cH:13][cH:12]1)[C:17](=[O:18])[N:19]1[CH2:20][CH2:21][N:22]([CH2:23][CH2:24]1)[c:25]1[cH:26][c:27]([c:28]([c:29]([cH:30]1)[CH3:31])[O:32][C:45](=[O:46])[NH:47][c:48]1[cH:49][cH:50][cH:51][c:52]2[c:53]1[CH2:54][N:55]([C:56]2=[O:57])[CH:58]1[CH2:59][CH2:60][C:61]([NH:62][C:63]1=[O:64])=[O:65])[CH3:33])-[c:34]1[cH:35][c:36]([c:37]([cH:38][c:39]1[OH:40])[OH:41])[CH:42]([CH3:43])[CH3:44]|US20200165201A1_0410
3.1.7|[C:6]-[C&H0&+0&D3:5](=[C:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[n:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:6]-[C&H0&+0&D3:5](=[C:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|CC1(OB(OC1(C)C)[C:1]1=[CH:2][CH2:3][O:4][CH2:5][CH2:6]1)C.[Br:7][c:8]1[cH:9][n:10][c:11]([n:12][cH:13]1)I>C1COCCO1.O>[Br:7][c:8]1[cH:13][n:12][c:11]([n:10][cH:9]1)[C:1]1=[CH:2][CH2:3][O:4][CH2:5][CH2:6]1|US20160311831A1_0165
5.3.2|[C&H3&D1:6]-[#14&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-Cl.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[#14&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])Cl.[OH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][Cl:15]>CN(C)C=O.c1c[nH]cn1>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][Cl:15]|EP3484894B1_0549
5.5.6|[C:7]-[C&H0&+0&D3:6](-[c:5])=O.[S&H1&+0&D1:4]-[C:3]-[C:2]-[S&H1&+0&D1:1]>>[C:7]-[C&H0&+0&D4:6]1(-[S&H0&+0&D2:4]-[C:3]-[C:2]-[S&H0&+0&D2:1]-1)-[c:5]|[ClH:1].O=[C:2]([CH2:3][n:4]1[cH:5][cH:6][n:7][cH:8]1)[c:9]1[cH:10][cH:11][c:12]2-[c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3[CH2:19][c:20]2[cH:21]1.[SH:22][CH2:23][CH2:24][SH:25]>O.CC(C)=O.CS(=O)(=O)O.O[Na]>[ClH:1].[cH:15]1[cH:16][cH:17][c:18]2[CH2:19][c:20]3[cH:21][c:9]([cH:10][cH:11][c:12]3-[c:13]2[cH:14]1)[C:2]1([S:22][CH2:23][CH2:24][S:25]1)[CH2:3][n:4]1[cH:5][cH:6][n:7][cH:8]1|US10556907B2_0456
1.6.2|[C:7]-[C&H1&+0&D3:6](-[C:5])-Br.[n:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[C:7]-[C&H1&+0&D3:6](-[C:5])-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[n:4]|[CH3:1][CH:2]([CH3:3])[CH:4](Br)[C:5](=[O:6])[N:7]1[CH2:8][CH2:9][CH:10]([CH2:11][CH2:12]1)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19].[cH:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)-[c:26]1[n:27][n:28][nH:29][n:30]1>CC#N.[O-]C([O-])=O.[K+].[K+]>[CH3:1][CH:2]([CH3:3])[CH:4]([C:5](=[O:6])[N:7]1[CH2:8][CH2:9][CH:10]([CH2:11][CH2:12]1)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19])[n:28]1[n:29][n:30][c:26]([n:27]1)-[c:23]1[cH:22][cH:21][cH:20][cH:25][cH:24]1|US07601844B2_0612
3.1.7|[c:6]:[c&H0&+0&D3:5](:[s:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|CC1(OB(OC1(C)C)[c:1]1[cH:2][cH:3][cH:4][s:5]1)C.[CH3:6][O:7][c:8]1[n:9][c:10]([n:11][cH:12][c:13]1I)[Cl:14]>>[CH3:6][O:7][c:8]1[n:9][c:10]([n:11][cH:12][c:13]1-[c:1]1[cH:2][cH:3][cH:4][s:5]1)[Cl:14]|EP2485731B1_0179
1.6.4|[C:7]-[C&H2&+0&D2:6]-Cl.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[C:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|[CH3:1][NH:2][c:3]1[n:4][cH:5][n:6][c:7]2[n:8][cH:9][nH:10][c:11]12.Cl[CH2:12][CH2:13][CH2:14][N:15]1[CH2:16][CH2:17][N:18]([CH2:19][CH2:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>CC(C)O.[Na]>[CH3:1][NH:2][c:3]1[n:4][cH:5][n:6][c:7]2[c:11]1[n:10][cH:9][n:8]2[CH2:12][CH2:13][CH2:14][N:15]1[CH2:16][CH2:17][N:18]([CH2:19][CH2:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1|US20070129334A1_0182
4.2.20|[C:7]-[C&H0&+0&D3:6](-[C:5])=O.[O&H1&+0&D1:4]-[C:3]-[C:2]-[O&H1&+0&D1:1]>>[C:7]-[C&H0&+0&D4:6]1(-[C:5])-[O&H0&+0&D2:4]-[C:3]-[C:2]-[O&H0&+0&D2:1]-1|[CH3:1][C:2]1=[CH:3][C:4]([CH2:5][C:6]([C:7]1=[O:8])([CH3:9])[CH3:10])=O.[CH3:11][CH:12]([OH:13])[CH2:14][OH:15]>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1.O>[CH3:1][C:2]1=[CH:3][C:4]2([CH2:5][C:6]([C:7]1=[O:8])([CH3:9])[CH3:10])[O:15][CH2:14][CH:12]([O:13]2)[CH3:11]|US20200172532A1_0357
9.7.78|[O:6]-[B&H0&+0&D3:5](-[O:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[O:6]-[B&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])B1OC(C(O1)(C)C)(C)C)[CH3:9].I[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[O:16][c:17]1[n:18][cH:19][cH:20][cH:21][n:22]1>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.CN(C)C=O.CC([O-])=O.ClCCl.Cl[Pd]Cl.[K+].[Fe+2]>[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[O:16][c:17]1[n:22][cH:21][cH:20][cH:19][n:18]1)[CH3:9]|EP3321261B1_0147
3.1.7|[c:6]:[c&H0&+0&D3:5](:[c:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[o:1])-I>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[o:1]|CC1(OB(OC1(C)C)[c:1]1[cH:2][cH:3][c:4]2[CH2:5][C@@H:6]3[CH2:7][CH2:8][C@@H:9]([C@@:10]33[CH2:11][N:12]([S:13]([NH:14]3)(=[O:15])=[O:16])[CH2:17][C:18]([F:19])([F:20])[F:21])[CH2:22][c:23]2[cH:24]1)C.I[c:25]1[cH:26][c:27]([n:28][o:29]1)-[c:30]1[cH:31][cH:32][cH:33][cH:34][n:35]1>Cc1ccccc1.O=C(O[K])O[K].O=C(O)O[Na].CCO.O>[O:15]=[S:13]1([NH:14][C@@:10]2([CH2:11][N:12]1[CH2:17][C:18]([F:19])([F:20])[F:21])[C@@H:9]1[CH2:8][CH2:7][C@H:6]2[CH2:5][c:4]2[cH:3][cH:2][c:1]([cH:24][c:23]2[CH2:22]1)-[c:25]1[cH:26][c:27]([n:28][o:29]1)-[c:30]1[cH:31][cH:32][cH:33][cH:34][n:35]1)=[O:16]|US20120309739A1_0257
1.2.3|[C:7]-[C&H0&+0&D3:6](-[N&H0&+0&D3:5](-[C:4])-[c:3]:[c:2]-[N&H2&+0&D1:1])=O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D3:5]:1-[C:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][c:9]([c:10]([cH:11][c:12]1[F:13])[NH2:14])[N:15]([CH2:16][c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)[Cl:23])[C:24](=O)[C:25]([F:26])([F:27])[F:28]>Cc1ccccc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][c:9]2[c:10]([cH:11][c:12]1[F:13])[n:14][c:24]([n:15]2[CH2:16][c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)[Cl:23])[C:25]([F:26])([F:27])[F:28]|US06649600B1
4.2.20|[C:7]-[C&H0&+0&D3:6](-[C:5])=O.[O&H1&+0&D1:4]-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[C:7]-[C&H0&+0&D4:6]1(-[C:5])-[O&H0&+0&D2:4]-[c:3]:[c:2]-[O&H0&+0&D2:1]-1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:7][CH2:8][CH2:9][C:10]1=O.[OH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[OH:18]>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1.O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:7][CH2:8][CH2:9][C:10]11[O:18][c:17]2[cH:16][cH:15][cH:14][cH:13][c:12]2[O:11]1|US20170349594A1_1508
1.6.4|[c:7]:[c&H0&+0&D3:6](:[n:5])-Cl.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[c:7]:[c&H0&+0&D3:6](:[n:5])-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|Cl[c:1]1[n:2][cH:3][n:4][cH:5][c:6]1[I:7].[cH:8]1[cH:9][nH:10][n:11][n:12]1>[NH4+].[Na+].[Cl-].CCOC(C)=O.C1CCOC1.[H-]>[I:7][c:6]1[cH:5][n:4][cH:3][n:2][c:1]1-[n:11]1[n:10][cH:9][cH:8][n:12]1|US20180170909A1_1852
3.9.37|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[O&H1&+0&D1:4])(-[c:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6]Br.[CH3:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[OH:16].[Zn]>CC1(CC(NN1)=O)c1ccc(cc1)O.Fc1ccc(cc1)I.[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:8]([CH3:7])([OH:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[OH:16]|US20190010265A1_0237
3.1.7|[c:6]:[c&H0&+0&D3:5](:[c:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[s:1])-I>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|CC1(OB(OC1(C)C)[c:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[C:7](=[O:8])[N:9]1[CH2:10][CH2:11][CH2:12][C@H:13]1[CH2:14][N:15]1[CH2:16][CH2:17][CH2:18][C@H:19]1[CH3:20])C.[N:21]#[C:22][c:23]1[cH:24][s:25][c:26]([cH:27]1)I>>[CH3:20][C@@H:19]1[CH2:18][CH2:17][CH2:16][N:15]1[CH2:14][C@@H:13]1[CH2:12][CH2:11][CH2:10][N:9]1[C:7](=[O:8])[c:4]1[cH:3][cH:2][c:1]([cH:6][cH:5]1)-[c:26]1[cH:27][c:23]([cH:24][s:25]1)[C:22]#[N:21]|EP3313817B1_0302
4.1.3|[N&H0&+0&D1:6]#[C&H0&+0&D2:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[N&H1&+0&D2:6]1-[C&H2&+0&D2:5]-[c:4]:[c:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[NH:8][c:9]1[n:10][c:11]([n:12][c:13]([c:14]1[C:15](=[O:16])OC)[C:17]#[N:18])[N:19]1[CH2:20][CH2:21][N:22]([CH2:23][CH2:24]1)[CH2:25][CH3:26]>Cl.CCO.[Pd]>[CH3:26][CH2:25][N:22]1[CH2:23][CH2:24][N:19]([CH2:20][CH2:21]1)[c:11]1[n:10][c:9]([c:14]2[C:15]([NH:18][CH2:17][c:13]2[n:12]1)=[O:16])[NH:8][c:6]1[cH:5][cH:4][cH:3][c:2]([cH:7]1)[CH3:1]|EP3489236B1_0583
1.6.2|[C:7]-[C&H2&+0&D2:6]-Br.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[C:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|[CH3:1][CH2:2][CH2:3][CH2:4]Br.[O-:5][N+:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]2[n:12][cH:13][nH:14][c:15]2[cH:16]1>O.CCO.O[K]>[CH3:1][CH2:2][CH2:3][CH2:4][n:12]1[cH:13][n:14][c:15]2[cH:16][c:8]([cH:9][cH:10][c:11]21)[N+:6]([O-:5])=[O:7]|US07750157B2_0076
3.1.3|[C:6]=[C&H0&+0&D3:5](-[c:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:6]=[C&H0&+0&D3:5](-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2]/[C:3]([B:4]1[O:5][C:6]([C:7]([O:8]1)([CH3:9])[CH3:10])([CH3:11])[CH3:12])=[C:13](/B1OC(C(O1)(C)C)(C)C)[c:14]1[cH:15][cH:16][c:17]2[c:18]([cH:19]1)[c:20]([n:21][n:22]2[CH:23]1[CH2:24][CH2:25][CH2:26][CH2:27][O:28]1)[F:29].[CH3:30][C:31]([CH3:32])([CH3:33])[O:34][C:35](=[O:36])[NH:37][CH2:38][CH2:39][O:40][c:41]1[cH:42][cH:43][c:44]([cH:45][cH:46]1)I>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=C(O[Cs])O[Cs].C1CCOC1.O>[CH3:1][CH2:2]/[C:3]([B:4]1[O:5][C:6]([C:7]([O:8]1)([CH3:9])[CH3:10])([CH3:11])[CH3:12])=[C:13](/[c:44]1[cH:43][cH:42][c:41]([cH:46][cH:45]1)[O:40][CH2:39][CH2:38][NH:37][C:35](=[O:36])[O:34][C:31]([CH3:30])([CH3:32])[CH3:33])[c:14]1[cH:15][cH:16][c:17]2[c:18]([cH:19]1)[c:20]([n:21][n:22]2[CH:23]1[CH2:24][CH2:25][CH2:26][CH2:27][O:28]1)[F:29]|US20200361918A1_0810
4.2.20|[C:7]-[C&H0&+0&D3:6](-[c:5])=O.[O&H1&+0&D1:4]-[C:3]-[C:2]-[O&H1&+0&D1:1]>>[C:7]-[C&H0&+0&D4:6]1(-[O&H0&+0&D2:4]-[C:3]-[C:2]-[O&H0&+0&D2:1]-1)-[c:5]|O=[C:1]([CH2:2][Br:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[Cl:10])[Cl:11].[OH:12][CH2:13][CH:14]([OH:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1.CCCCO.O>[Cl:11][c:7]1[cH:6][cH:5][c:4]([c:9]([cH:8]1)[Cl:10])[C:1]1([O:12][CH2:13][CH:14]([O:15]1)[c:16]1[cH:21][cH:20][cH:19][cH:18][cH:17]1)[CH2:2][Br:3]|EP2452984A1_0065
4.1.46|[N&H2&+0&D1:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-N)-N>>[n&H1&+0&D2:6]1:[c:5]:[c:4]:[n&H1&+0&D2:3]:[c&H0&+0&D3:1]:1=[O&H0&D1:2]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH2:8].N[C:9](N)=[O:10]>>[O:10]=[c:9]1[nH:1][c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[nH:8]1|US09475816B2_0176
1.6.2|[C:7]-[C&H2&+0&D2:6]-Br.[c:5]1:[n&H1&+0&D2:4]:[n:3]:[n&H0&+0&D2:2]:[n:1]:1>>[C:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:2]1:[n:1]:[c:5]:[n&H0&+0&D2:4]:[n:3]:1|[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[CH:7]([S:8][c:9]1[n:10][n:11][n:12][nH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[CH:20]#[C:21][CH2:22]Br>CCN(CC)CC.C1CCOC1>[CH:20]#[C:21][CH2:22][n:11]1[n:12][n:13][c:9]([n:10]1)[S:8][CH:7]([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:4]1[cH:5][cH:6][cH:1][cH:2][cH:3]1|US20180282331A1_0636
4.1.16|[C:7]-[C&H0&+0&D3:6](-O)=O.[C:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D3:4]:1-[C:5]|[CH3:1][CH2:2][C:3](=O)O.[NH2:4][c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[NH:11][CH2:12][CH2:13][CH2:14][OH:15])[Cl:16]>O.Cl.C>[CH3:1][CH2:2][c:3]1[n:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[n:11]1[CH2:12][CH2:13][CH2:14][OH:15])[Cl:16]|US07803816B2_0083
8.1.5|[C&H3&D1:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[C@&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][S:2][C:3]([CH2:4][C@@H:5]1[CH:6]([C:7]([N:8]1[Si:9]([CH3:10])([CH3:11])[C:12]([CH3:13])([CH3:14])[CH3:15])=[O:16])[CH:17]([CH3:18])[OH:19])([S:20][CH3:21])[S:22][CH3:23]>O=C(OC(=O)C(F)(F)F)C(F)(F)F.CCN(CC)CC.CS(C)=O.ClCCl>[CH3:1][S:2][C:3]([CH2:4][C@@H:5]1[C@H:6]([C:7]([N:8]1[Si:9]([CH3:10])([CH3:11])[C:12]([CH3:13])([CH3:14])[CH3:15])=[O:16])[C:17]([CH3:18])=[O:19])([S:20][CH3:21])[S:22][CH3:23]|EP3750909A1_0070
1.6.2|[c:7]:[c&H0&+0&D3:6](:[c:5])-Br.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[c:1]>>[c:7]:[c&H0&+0&D3:6](:[c:5])-[n&H0&+0&D3:2](:[c:1]):[n&H0&+0&D2:3]:[c:4]|[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)Br.[cH:8]1[cH:9][cH:10][c:11]2[nH:12][n:13][cH:14][c:15]2[cH:16]1>Cc1ccccc1.[O-]P([O-])([O-])=O.I[Cu].[K+].[K+].[K+]>[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[n:13]1[cH:14][c:15]2[cH:16][cH:8][cH:9][cH:10][c:11]2[n:12]1|US20200207736A1_0315
3.9.2|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=[O&H0&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C:4])(-[O&H1&+0&D1:3])-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])[CH2:4][CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]1.[CH:11]#[C:12][CH2:13]Br>c1ccccc1.CCOCC.Cl[Hg]Cl.Cl.[Mg]>[CH:11]#[C:12][CH2:13][C:2]([CH3:1])([OH:3])[CH2:4][CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]1|US09526737B2_0178
1.6.2|[c:7]:[c&H0&+0&D3:6](:[c:5])-Br.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n:1]>>[c:7]:[c&H0&+0&D3:6](:[c:5])-[n&H0&+0&D3:2](:[n:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([cH:7][n:8]1)Br.[cH:9]1[cH:10][nH:11][n:12][n:13]1>>[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([cH:7][n:8]1)-[n:12]1[n:11][cH:10][cH:9][n:13]1|US20200339536A1_0847
1.6.2|[C:7]-[C&H1&+0&D3:6](-[C:5])-Br.[c:4]:[n&H0&+0&D2:3]:[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H1&+0&D3:6](-[C:5])-[n&H0&+0&D3:3](:[c:4]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[n:10][nH:11][c:12]2[c:13]([cH:14][cH:15][cH:16][c:17]12)[Cl:18].Br[CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23]1>[NaH]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[c:17]2[cH:16][cH:15][cH:14][c:13]([c:12]2[n:11][n:10]1[CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23]1)[Cl:18]|US20180244627A1_0224
1.7.9|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4]-[O&H0&+0&D2:3]-C)-Br.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[O&H0&+0&D2:2]-[c:1])-[C:4]-[O&H1&+0&D1:3]|[CH3:1][CH2:2][CH2:3][S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[C:13]#[C:14][c:15]1[cH:16][c:17]([cH:18][cH:19][c:20]1[OH:21])[Cl:22])[CH3:23].C[O:24][C:25](=[O:26])[CH:27]([CH3:28])Br>O.[Na+].Cl.CO.COCCOC.[O-]C([O-])=O.[OH-].[K+].[K+]>[CH3:28][CH:27]([O:21][c:20]1[cH:19][cH:18][c:17]([cH:16][c:15]1[C:14]#[C:13][c:11]1[cH:12][c:7]([cH:8][cH:9][c:10]1[CH3:23])[S:4](=[O:5])(=[O:6])[CH2:3][CH2:2][CH3:1])[Cl:22])[C:25](=[O:26])[OH:24]|EP2024355B1_0105
4.1.16|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[C&H1&+0&D2:1](=O)-O>>[C&H3&D1:6]-[n&H0&+0&D3:5]1:[c&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c:3]:[c:4]:1|[CH3:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[c:10]([c:11]1[NH2:12])[NH:13][CH3:14])[F:15].O=[CH:16]O>>[CH3:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[c:10]2[c:11]1[n:12][cH:16][n:13]2[CH3:14])[F:15]|US20190202829A1_0289
3.1.3|[C:6]=[C&H0&+0&D3:5](-[C:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:6]=[C&H0&+0&D3:5](-[C:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|CC1(OB(OC1(C)C)[C:1]1=[CH:2][CH2:3][N:4]([CH2:5][CH2:6]1)[C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])C.[NH2:14][c:15]1[n:16][c:17]2[c:18]([s:19]1)[cH:20][cH:21][cH:22][c:23]2[O:24][c:25]1[cH:26][c:27]([n:28][cH:29][n:30]1)I>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.COCCOC.[O-]C([O-])=O.CCO.O.[Na+].[Na+]>[CH3:11][C:10]([CH3:12])([CH3:13])[O:9][C:7](=[O:8])[N:4]1[CH2:3][CH:2]=[C:1]([CH2:6][CH2:5]1)[c:27]1[cH:26][c:25]([n:30][cH:29][n:28]1)[O:24][c:23]1[cH:22][cH:21][cH:20][c:18]2[c:17]1[n:16][c:15]([s:19]2)[NH2:14]|EP3368539B1_0324
1.6.4|[O:7]-[C&H2&+0&D2:6]-Cl.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[O:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|[NH2:1][c:2]1[n:3][c:4]([c:5]2[nH:6][cH:7][n:8][c:9]2[n:10]1)[Cl:11].[O:12]=[C:13]([O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH2:21]Cl)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>O.CN(C)C=O.O=C(O[K])O[K]>[NH2:1][c:2]1[n:3][c:4]([c:5]2[n:6][cH:7][n:8]([c:9]2[n:10]1)[CH2:21][O:20][CH2:19][CH2:18][O:17][CH2:16][CH2:15][O:14][C:13](=[O:12])[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[Cl:11]|EP3400221B1_0269
3.1.3|[c:6]:[c&H0&+0&D3:5](:[n:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|CC1(OB(OC1(C)C)[c:1]1[cH:2][c:3]2[cH:4][cH:5][cH:6][n:7][c:8]2[n:9]1[CH3:10])C.[CH3:11][CH2:12][CH:13]([CH2:14][CH3:15])[c:16]1[cH:17][c:18]([n:19][n:20]2[c:21]1[n:22][c:23]([c:24]2I)[CH3:25])[CH3:26]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.COCCOC.[O-]C([O-])=O.CCO.ClCCl.O.[Na+].[Na+]>[CH3:11][CH2:12][CH:13]([CH2:14][CH3:15])[c:16]1[cH:17][c:18]([n:19][n:20]2[c:21]1[n:22][c:23]([c:24]2-[c:1]1[cH:2][c:3]2[cH:4][cH:5][cH:6][n:7][c:8]2[n:9]1[CH3:10])[CH3:25])[CH3:26]|EP3107920B1_0424
5.3.2|[C&H3&D1:6]-[#14&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[#14&H0&+0&D4:5](-[C&H3&D1:4])(-[C:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][c:2]1[c:3]2[O:4][CH:5]([S:6][c:7]2[c:8]([c:9]([c:10]1[CH3:11])[OH:12])[CH3:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[CH3:20][C:21]([CH3:22])([CH3:23])[Si:24]([CH3:25])([CH3:26])Cl>CN(C)C=O.c1c[nH]cn1.O>[CH3:1][c:2]1[c:3]2[O:4][CH:5]([S:6][c:7]2[c:8]([c:9]([c:10]1[CH3:11])[O:12][Si:24]([CH3:25])([CH3:26])[C:21]([CH3:20])([CH3:22])[CH3:23])[CH3:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|EP3224253B1_0098
3.9.1|[C&H3&D1:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]=[O:3].[Cl:4][c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)Br>[NH4+].O.[Cl-].C1CCOC1.[Mg]>[CH3:1][CH:2]([OH:3])[c:7]1[cH:8][cH:9][c:10]([c:5]([cH:6]1)[Cl:4])-[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US20190337961A1_0528
5.5.6|[C:7]-[C&H0&+0&D3:6](-[C:5])=O.[S&H1&+0&D1:4]-[C:3]-[C:2]-[S&H1&+0&D1:1]>>[C:7]-[C&H0&+0&D4:6]1(-[C:5])-[S&H0&+0&D2:4]-[C:3]-[C:2]-[S&H0&+0&D2:1]-1|[CH3:1][CH2:2][CH2:3][C:4](=O)[CH2:5][CH2:6][n:7]1[cH:8][cH:9][n:10][cH:11]1.[SH:12][CH2:13][CH2:14][SH:15]>CS(=O)(=O)O.ClCCl>[CH3:1][CH2:2][CH2:3][C:4]1([S:12][CH2:13][CH2:14][S:15]1)[CH2:5][CH2:6][n:7]1[cH:8][cH:9][n:10][cH:11]1|US09062075B2_0227
5.5.6|[S&H1&+0&D1:7]-[C:6]-[C:5]-[S&H1&+0&D1:4].[c:3]-[C&H0&+0&D3:2](-[c:1])=O>>[S&H0&+0&D2:7]1-[C:6]-[C:5]-[S&H0&+0&D2:4]-[C&H0&+0&D4:2]-1(-[c:3])-[c:1]|O=[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[SH:14][CH2:15][CH2:16][SH:17]>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1.O>[cH:11]1[cH:12][cH:13][c:8]([cH:9][cH:10]1)[C:1]1([S:17][CH2:16][CH2:15][S:14]1)[c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1|US20200206225A1_0370
1.8.1|[C:6]-[C&H2&+0&D2:5]-Br.[O&H0&D1:4]=[S&H0&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]>>[C:6]-[C&H2&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&+0&D1:2])-[c:1]|[CH2:1]=[CH:2][CH2:3]Br.[CH3:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[S:14](=[O:15])[OH:16]>O.[Na+].[O-]C(=O)O>[CH2:1]=[CH:2][CH2:3][S:14](=[O:16])(=[O:15])[c:11]1[cH:12][cH:13][c:8]([cH:9][cH:10]1)[NH:7][C:5]([CH3:4])=[O:6]|US20040157149A1_0068
1.6.2|[c:7]-[C&H2&+0&D2:6]-Br.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[c:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH2:12]Br.[cH:13]1[cH:14][c:15]2[nH:16][cH:17][n:18][c:19]2[cH:20][n:21]1>CCOC(C)=O.CN(C)C=O.[H][H].[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH2:12][n:18]1[cH:17][n:16][c:15]2[cH:14][cH:13][n:21][cH:20][c:19]21|US09840497B2_0570
3.1.3|[C:6]-[C&H0&+0&D3:5](=[C:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[s:1])-I>>[C:6]-[C&H0&+0&D3:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|CC1(OB(OC1(C)C)[C:1]1=[CH:2][CH2:3][N:4]([CH2:5][CH2:6]1)[C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])C.[NH2:14][c:15]1[cH:16][cH:17][c:18]([c:19]([cH:20]1)[F:21])[O:22][c:23]1[cH:24][cH:25][n:26][c:27]2[c:28]1[s:29][c:30]([cH:31]2)I>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.COCCOC.[O-]C([O-])=O.[Na+].[Na+]>[CH3:11][C:10]([CH3:12])([CH3:13])[O:9][C:7](=[O:8])[N:4]1[CH2:3][CH:2]=[C:1]([CH2:6][CH2:5]1)[c:30]1[cH:31][c:27]2[n:26][cH:25][cH:24][c:23]([c:28]2[s:29]1)[O:22][c:18]1[cH:17][cH:16][c:15]([cH:20][c:19]1[F:21])[NH2:14]|US20200199148A1_1555
1.6.4|[c:7]-[C&H2&+0&D2:6]-Cl.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[c:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|[CH3:1][NH:2][c:3]1[n:4][cH:5][n:6][c:7]2[n:8][cH:9][nH:10][c:11]12.[F:12][c:13]1[cH:14][cH:15][cH:16][c:17]([c:18]1[CH2:19]Cl)[Cl:20]>CC(=O)N(C)C.O=C(O[K])O[K]>[CH3:1][NH:2][c:3]1[n:4][cH:5][n:6][c:7]2[c:11]1[n:10][cH:9][n:8]2[CH2:19][c:18]1[c:13]([cH:14][cH:15][cH:16][c:17]1[Cl:20])[F:12]|US20170049772A1_0527
3.1.3|[c:6]:[c&H0&+0&D3:5](:[s:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|CC1(OB(OC1(C)C)[c:1]1[cH:2][c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[s:9]1)[CH:10]=[O:11])C.[CH3:12][CH:13]([CH3:14])[n:15]1[n:16][c:17]([c:18]2[c:19]1[n:20][cH:21][n:22][c:23]2[NH2:24])I>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.COCCOC.[O-]C([O-])=O.CCO.[Na+].[Na+]>[CH3:12][CH:13]([CH3:14])[n:15]1[n:16][c:17]([c:18]2[c:19]1[n:20][cH:21][n:22][c:23]2[NH2:24])-[c:1]1[cH:2][c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[s:9]1)[CH:10]=[O:11]|US20200179383A1_1493
1.6.4|[O:7]-[C&H2&+0&D2:6]-Cl.[c:5]1:[n&H0&+0&D2:4]:[c:3]:[n&H1&+0&D2:2]:[o:1]:1>>[O:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:4]1:[c:5]:[o:1]:[n&H0&+0&D2:2]:[c:3]:1|[O:1]=[c:2]1[n:3][c:4]([nH:5][o:6]1)-[c:7]1[cH:8][c:9]([cH:10][cH:11][n:12]1)[C:13]([F:14])([F:15])[F:16].[CH3:17][C:18]([CH3:19])([CH3:20])[C:21](=[O:22])[O:23][CH2:24]Cl>CN(C)C=O.[NH4+].[Cl-].[NaH]>[CH3:17][C:18]([CH3:19])([CH3:20])[C:21](=[O:22])[O:23][CH2:24][n:3]1[c:2]([o:6][n:5][c:4]1-[c:7]1[cH:8][c:9]([cH:10][cH:11][n:12]1)[C:13]([F:14])([F:15])[F:16])=[O:1]|US20120041009A1_0345
1.6.2|[c:7]-[C&H2&+0&D2:6]-Br.[c:5]1:[n&H1&+0&D2:4]:[n:3]:[n&H0&+0&D2:2]:[n:1]:1>>[c:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:2]1:[n:1]:[c:5]:[n&H0&+0&D2:4]:[n:3]:1|[CH3:1][CH2:2][N:3]1[C:4](=[C:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[S:12]1(=[O:13])=[O:14])[OH:15])[c:16]1[n:17][n:18][n:19][nH:20]1.Br[CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>O.CN(C)C=O.O=C(O[K])O[K]>[CH3:1][CH2:2][N:3]1[C:4](=[C:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[S:12]1(=[O:13])=[O:14])[OH:15])[c:16]1[n:20][n:19][n:18]([n:17]1)[CH2:21][c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1|US20120128630A1_0309
2.4.8|[O&H0&D1:5]=[C&H0&+0&D3:4](-[O:3])-O-c1:c:c:c(:c:c:1)-[N&+](-[O&-])=O.[O&H1&+0&D1:2]-[c:1]>>[O&H0&D1:5]=[C&H0&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[O:3]|[CH3:1][N:2]([CH3:3])[C@@H:4]([CH3:5])[c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[OH:12].[O-:13][N+:14](=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[O:22][C:23](=[O:24])Oc1ccc(cc1)[N+]([O-])=O>ClCCl>[CH3:5][C@@H:4]([c:6]1[cH:11][c:10]([cH:9][cH:8][cH:7]1)[O:12][C:23](=[O:24])[O:22][c:19]1[cH:18][cH:17][c:16]([cH:21][cH:20]1)[N+:14]([O-:13])=[O:15])[N:2]([CH3:1])[CH3:3]|US09265768B2_0936
9.7.311|[O:6]-[B&H0&+0&D3:5](-[O:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-N>>[O:6]-[B&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])B1OC(C(O1)(C)C)(C)C)[CH3:9].[CH3:10][O:11][c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[Br:18])N>CC(C)c1cccc(c1-n1ccn(c1=[ClH])-c1c(cccc1C(C)C)C(C)C)C(C)C.F[B-](F)(F)F.C1CCOC1.CC([O-])=O.CC([O-])=O.CC(C)=O.[O-]N=O.O=C=O.ClCCl.O.[Na+].Cl.[H+].[Pd+2]>[CH3:10][O:11][c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[Br:18])[B:4]1[O:3][C:2]([C:6]([O:5]1)([CH3:7])[CH3:8])([CH3:1])[CH3:9]|US20200115362A1_0444
4.1.3|[N&H0&+0&D1:6]#[C&H0&+0&D2:5]-[C:4]-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[N&H1&+0&D2:6]1-[C&H2&+0&D2:5]-[C:4]-[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|CO[C:1](=[O:2])[CH2:3][CH:4]([C:5]#[N:6])[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[Cl:14]>[Ni]>[O:2]=[C:1]1[CH2:3][CH:4]([CH2:5][NH:6]1)[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[Cl:14]|US20180148418A1_1457
1.6.4|[c:7]:[c&H0&+0&D3:6](:[n:5])-Cl.[c:4]:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[c:1]>>[c:7]:[c&H0&+0&D3:6](:[n:5])-[n&H0&+0&D3:2](:[c:1]):[n&H0&+0&D2:3]:[c:4]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][c:11]2[nH:12][n:13][cH:14][c:15]2[CH2:16]1.[CH3:17][c:18]1[cH:19][cH:20][c:21]([n:22][n:23]1)Cl>CC(C)c1cc(c(c(c1)C(C)C)-c1ccccc1P(C(C)(C)C)C(C)(C)C)C(C)C.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.Cc1ccccc1.CC(=O)OCC.CC(C)(C)[O-].O.[Na+].[Pd].[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][c:11]2[n:12][n:13]([cH:14][c:15]2[CH2:16]1)-[c:21]1[cH:20][cH:19][c:18]([n:23][n:22]1)[CH3:17]|US20180194997A1_0396
3.1.3|[c:6]:[c&H0&+0&D3:5](:[n:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[N:1]#[C:2][c:3]1[c:4]([nH:5][c:6]2[s:7][cH:8][c:9]([c:10]2[c:11]1[OH:12])-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)I)=[O:19].CC1(OB(OC1(C)C)[c:20]1[cH:21][cH:22][nH:23][n:24]1)C>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1COCCO1.CN(C)C=O.[O-]C([O-])=O.O=[Mg].[Cs+].[Cs+]>[N:1]#[C:2][c:3]1[c:4]([nH:5][c:6]2[s:7][cH:8][c:9]([c:10]2[c:11]1[OH:12])-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)-[c:20]1[cH:21][cH:22][nH:23][n:24]1)=[O:19]|EP3464246B1_0101
9.7.20|[O:6]-[B&H0&+0&D3:5](-[O:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[O:6]-[B&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])B1OC(C(O1)(C)C)(C)C)[CH3:9].[NH2:10][C:11](=[O:12])[c:13]1[cH:14][cH:15][c:16]([s:17]1)Br>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.C1COCCO1.CC([O-])=O.Cl[Pd]Cl.[K+].[Fe+2]>[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])[c:16]1[cH:15][cH:14][c:13]([s:17]1)[C:11]([NH2:10])=[O:12])[CH3:9]|EP3626716A1_1317
3.1.5|[C:6]-[C&H0&+0&D3:5](=[C:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:6]-[C&H0&+0&D3:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[O:1]=[S:2]1([NH:3][C:4]2([CH2:5][N:6]1[CH2:7][C:8]([F:9])([F:10])[F:11])[CH:12]1[CH2:13][CH2:14][CH:15]2[CH2:16][c:17]2[cH:18][cH:19][c:20]([cH:21][c:22]2[CH2:23]1)-[c:24]1[n:25][cH:26][c:27]([s:28]1)Br)=[O:29].CC1(OB(OC1(C)C)[C:30]1=[CH:31][CH2:32][N:33]([CH2:34][CH2:35]1)[C:36](=[O:37])[O:38][C:39]([CH3:40])([CH3:41])[CH3:42])C>>[CH3:40][C:39]([CH3:41])([CH3:42])[O:38][C:36](=[O:37])[N:33]1[CH2:32][CH:31]=[C:30]([CH2:35][CH2:34]1)[c:27]1[cH:26][n:25][c:24]([s:28]1)-[c:20]1[cH:19][cH:18][c:17]2[CH2:16][CH:15]3[CH2:14][CH2:13][CH:12]([CH2:23][c:22]2[cH:21]1)[C:4]31[CH2:5][N:6]([S:2]([NH:3]1)(=[O:1])=[O:29])[CH2:7][C:8]([F:9])([F:10])[F:11]|US20120095046A1_0782
9.7.20|[C:6]-[C&H0&+0&D3:5](=[C:4])-Br.[O:3]-[B&H0&+0&D3:2](-[O:1])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1>>[C:6]-[C&H0&+0&D3:5](=[C:4])-[B&H0&+0&D3:2](-[O:3])-[O:1]|[CH3:1][C:2]1([CH:3]=[C:4]([CH:5]=[C:6]2[C:7]1=[c:8]1[cH:9][c:10]3[c:11]4[cH:12][cH:13][cH:14][cH:15][c:16]4[c:17]4[cH:18][cH:19][cH:20][cH:21][c:22]4[c:23]3[cH:24][c:25]1=[CH:26]2)Br)[CH3:27].[CH3:28][C:29]1([O:30][B:31]([O:32][C:33]1([CH3:34])[CH3:35])B1OC(C(O1)(C)C)(C)C)[CH3:36]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1COCCO1.CC([O-])=O.[K+]>[CH3:28][C:29]1([O:30][B:31]([O:32][C:33]1([CH3:34])[CH3:35])[C:4]1[CH:5]=[C:6]2[CH:26]=[c:25]3[cH:24][c:23]4[c:22]5[cH:21][cH:20][cH:19][cH:18][c:17]5[c:16]5[cH:15][cH:14][cH:13][cH:12][c:11]5[c:10]4[cH:9][c:8]3=[C:7]2[C:2]([CH:3]=1)([CH3:1])[CH3:27])[CH3:36]|EP3303326B1_0482
8.8.18|[C:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[N&H0&+0&D3:4](-[C:3])-[c:2]:[c:1]-1>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[n&H0&+0&D3:4](-[C:3]):[c:2]:[c:1]:1|[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][CH2:14][C@H:15]1[CH2:16][CH:17]1[CH2:18][N:19]([c:20]2[cH:21][c:22]([cH:23][cH:24][c:25]21)[F:26])[C@@H:27]1[O:28][CH2:29][C@H:30]([C@@H:31]([C@H:32]1[OH:33])[OH:34])[OH:35]>N#CC1=C(C(C(=C(C1=O)Cl)Cl)=O)C#N>[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][CH2:14][C@H:15]1[CH2:16][c:17]1[cH:18][n:19]([c:20]2[cH:21][c:22]([cH:23][cH:24][c:25]12)[F:26])[C@@H:27]1[O:28][CH2:29][C@H:30]([C@@H:31]([C@H:32]1[OH:33])[OH:34])[OH:35]|US20200095271A1_0135
4.2.17|[C&H3&D1:6]-[C&H0&+0&D3:5](-Cl)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[o&H0&+0&D2:1]:1|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[OH:8])[OH:9].[CH3:10][C:11](=O)Cl.Cl>Cc1ccc(cc1)S(=O)(=O)O.CCN(CC)CC.c1ccncc1>[CH3:10][c:11]1[n:1][c:2]2[cH:3][cH:4][c:5]([cH:6][c:7]2[o:8]1)[OH:9]|US20200163953A1_1030
9.7.20|[O:6]-[B&H0&+0&D3:5](-[O:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O:6]-[B&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])B1OC(C(O1)(C)C)(C)C)[CH3:9].Br[c:10]1[cH:11][cH:12][c:13]2[c:14]([cH:15]1)[n:16][cH:17][n:18]2-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>[CH]1[CH][CH][C]([CH]1)[PH+](c1ccccc1)c1ccccc1.[CH]1[CH][CH][C]([CH]1)[PH+](c1ccccc1)c1ccccc1.CN(C)C=O.CC([O-])=O.ClCCl.Cl[Pd]Cl.[K+].[Fe]>[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])[c:10]1[cH:11][cH:12][c:13]2[c:14]([cH:15]1)[n:16][cH:17][n:18]2-[c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1)[CH3:9]|EP3484878B1_2808
9.7.37|[O:6]-[B&H0&+0&D3:5](-[O:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[O:6]-[B&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][CH2:8][n:9]1[n:10][c:11]([c:12]2[cH:13][cH:14][c:15]([cH:16][c:17]21)Cl)[NH:18][C:19](=[O:20])[CH2:21][CH2:22][CH3:23].[CH3:24][C:25]1([O:26][B:27]([O:28][C:29]1([CH3:30])[CH3:31])B1OC(C(O1)(C)C)(C)C)[CH3:32]>CC(=O)O[Pd]OC(C)=O.CCOC(C)=O.C1COCCO1.F[Cs].O>[CH3:23][CH2:22][CH2:21][C:19](=[O:20])[NH:18][c:11]1[n:10][n:9]([c:17]2[cH:16][c:15]([cH:14][cH:13][c:12]12)[B:27]1[O:26][C:25]([C:29]([O:28]1)([CH3:30])[CH3:31])([CH3:24])[CH3:32])[CH2:8][O:7][CH2:6][CH2:5][Si:2]([CH3:1])([CH3:3])[CH3:4]|EP3204360B1_0715
3.1.2|[c:6]:[c&H0&+0&D3:5](:[c:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[o:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[o:1]|CC1(OB(OC1(C)C)[c:1]1[cH:2][cH:3][c:4]([c:5]2[c:6]1[s:7][c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[c:14]2=[O:15])[F:16])C.[O:17]=[c:18]1[cH:19][c:20]([o:21][c:22]([cH:23]1)Cl)[N:24]1[CH2:25][CH2:26][O:27][CH2:28][CH2:29]1>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=C(O[K])O[K].C1COCCO1.N#N>[O:15]=[c:14]1[c:13]2[cH:12][cH:11][cH:10][cH:9][c:8]2[s:7][c:6]2[c:5]1[c:4]([cH:3][cH:2][c:1]2-[c:22]1[cH:23][c:18]([cH:19][c:20]([o:21]1)[N:24]1[CH2:25][CH2:26][O:27][CH2:28][CH2:29]1)=[O:17])[F:16]|US08378104B2_0653
3.1.2|[C:6]-[C&H0&+0&D3:5](=[C:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:6]-[C&H0&+0&D3:5](=[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[c:14]1[cH:15][cH:16][c:17]([cH:18][c:19]1Cl)[N+:20]([O-:21])=[O:22].CC1(OB(OC1(C)C)[C:23]1=[CH:24][C:25]([CH2:26][C:27]([CH2:28]1)([CH3:29])[CH3:30])([CH3:31])[CH3:32])C>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=P(O[K])(O[K])O[K].COCCOC.CCOC(C)=O.O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[c:14]1[cH:15][cH:16][c:17]([cH:18][c:19]1[C:23]1=[CH:24][C:25]([CH2:26][C:27]([CH2:28]1)([CH3:29])[CH3:30])([CH3:31])[CH3:32])[N+:20]([O-:21])=[O:22]|EP3418281B1_0561
9.7.20|[O:6]-[B&H0&+0&D3:5](-[O:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[O:6]-[B&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[c:16]1[n:17][cH:18][c:19]([n:20][c:21]1[O:22][CH3:23])Br.[CH3:24][C:25]1([O:26][B:27]([O:28][C:29]1([CH3:30])[CH3:31])B1OC(C(O1)(C)C)(C)C)[CH3:32]>Cc1ccccc1.CC([O-])=O.[K+]>[CH3:23][O:22][c:21]1[n:20][c:19]([cH:18][n:17][c:16]1[N:8]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[B:27]1[O:26][C:25]([C:29]([O:28]1)([CH3:30])[CH3:31])([CH3:24])[CH3:32]|US20200181151A1_0534
3.1.6|[c:6]:[c&H0&+0&D3:5](:[s:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[s:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[cH:12][c:13]([n:14][c:15]([n:16]1)-[c:17]1[cH:18][cH:19][n:20][c:21]([cH:22]1)Cl)[C:23]([F:24])([F:25])[F:26].CC1(OB(OC1(C)C)[c:27]1[cH:28][cH:29][c:30]([s:31]1)[S:32](=[O:33])(=[O:34])[NH:35][C:36]([CH3:37])([CH3:38])[CH3:39])C>>[CH3:37][C:36]([CH3:38])([CH3:39])[NH:35][S:32](=[O:33])(=[O:34])[c:30]1[cH:29][cH:28][c:27]([s:31]1)-[c:21]1[cH:22][c:17]([cH:18][cH:19][n:20]1)-[c:15]1[n:16][c:11]([cH:12][c:13]([n:14]1)[C:23]([F:24])([F:25])[F:26])-[c:8]1[cH:9][cH:10][c:5]([cH:6][cH:7]1)[C:2]([F:1])([F:3])[F:4]|US20200179383A1_1489
3.1.6|[c:6]:[c&H0&+0&D3:5](:[o:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[o:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|CC1(OB(OC1(C)C)[c:1]1[cH:2][n:3][c:4]([o:5]1)[Si:6]([CH:7]([CH3:8])[CH3:9])([CH:10]([CH3:11])[CH3:12])[CH:13]([CH3:14])[CH3:15])C.[CH3:16][C:17]([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH2:24][CH2:25][CH:26]([CH2:27][CH2:28]1)[CH:29]1[CH2:30][c:31]2[cH:32][c:33]([n:34][cH:35][c:36]2[O:37]1)Cl>>[CH3:14][CH:13]([CH3:15])[Si:6]([c:4]1[n:3][cH:2][c:1]([o:5]1)-[c:33]1[cH:32][c:31]2[CH2:30][CH:29]([O:37][c:36]2[cH:35][n:34]1)[CH:26]1[CH2:25][CH2:24][N:23]([CH2:28][CH2:27]1)[C:21](=[O:22])[O:20][C:17]([CH3:16])([CH3:18])[CH3:19])([CH:7]([CH3:8])[CH3:9])[CH:10]([CH3:11])[CH3:12]|EP3221317B1_1861
3.1.2|[c:6]:[c&H0&+0&D3:5](:[n:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[NH2:1][C:2](=[O:3])[CH:4]1[CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[c:10]1[c:11]([cH:12][n:13][cH:14][c:15]1Cl)[Cl:16].CC1(OB(OC1(C)C)[c:17]1[cH:18][cH:19][n:20][nH:21]1)C>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.O=C(O[Na])O[Na].CC#N>[NH2:1][C:2](=[O:3])[CH:4]1[CH2:5][CH2:6][N:7]([CH2:8][CH2:9]1)[c:10]1[c:11]([cH:12][n:13][cH:14][c:15]1-[c:17]1[cH:18][cH:19][n:20][nH:21]1)[Cl:16]|US20200199131A1_0873
3.1.6|[c:6]:[c&H0&+0&D3:5](:[n:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|CC1(OB(OC1(C)C)[c:1]1[cH:2][cH:3][c:4]2[n:5][c:6]([cH:7][n:8]2[n:9]1)[NH:10][C:11]([CH3:12])=[O:13])C.[O:14]=[S:15](=[O:16])([NH:17][c:18]1[cH:19][c:20]([n:21][n:22][c:23]1[Cl:24])Cl)[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[F:31]>O=C(O[Cs])O[Cs].C1COCCO1.[NH4+].O.[Cl-]>[CH3:12][C:11](=[O:13])[NH:10][c:6]1[cH:7][n:8]2[n:9][c:1]([cH:2][cH:3][c:4]2[n:5]1)-[c:20]1[cH:19][c:18]([c:23]([n:22][n:21]1)[Cl:24])[NH:17][S:15](=[O:14])(=[O:16])[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[F:31]|EP2528917B1_0235
9.7.37|[O:6]-[B&H0&+0&D3:5](-[O:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[O:6]-[B&H0&+0&D3:5](-[O:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])B1OC(C(O1)(C)C)(C)C)[CH3:9].[CH3:10][C:11](=[O:12])[NH:13][c:14]1[cH:15][n:16]2[n:17][c:18]([cH:19][cH:20][c:21]2[n:22]1)Cl>c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.c1ccc(cc1)P(c1ccccc1)[c-]1cccc1.C1COCCO1.CC([O-])=O.Cl[Pd]Cl.[K+].[Fe+2]>[CH3:10][C:11](=[O:12])[NH:13][c:14]1[cH:15][n:16]2[n:17][c:18]([cH:19][cH:20][c:21]2[n:22]1)[B:4]1[O:3][C:2]([C:6]([O:5]1)([CH3:7])[CH3:8])([CH3:1])[CH3:9]|EP3322706B1_0533
3.9.67|[C&H3&+0&D1:5]-[C&H2&+0&D2:4]-[#12]-Br.[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[C&H2&+0&D2:5]1-[C&H0&+0&D4:2](-[N&H2&+0&D1:3])(-[c:1])-[C&H2&+0&D2:4]-1|[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][c:6]1[cH:7][cH:8][n:9][c:10]([cH:11]1)[C:12]#[N:13].[CH3:14][CH2:15][Mg]Br>CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C.C1CCOC1>[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][c:6]1[cH:7][cH:8][n:9][c:10]([cH:11]1)[C:12]1([CH2:15][CH2:14]1)[NH2:13]|EP3019483B1_0170
3.9.67|[C&H3&+0&D1:5]-[C&H2&+0&D2:4]-[#12]-Br.[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[C&H2&+0&D2:5]1-[C&H0&+0&D4:2](-[C:3])(-[N&H2&+0&D1:1])-[C&H2&+0&D2:4]-1|[CH3:1][C:2]1([O:3][C:4]([N:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21)[CH2:12][CH2:13][C:14]#[N:15])=[O:16])[CH3:17].[CH3:18][CH2:19][Mg]Br>CCOCC.CCOCC.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].FB(F)F.O[Na].[Ti+4]>[CH3:1][C:2]1([O:3][C:4]([N:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21)[CH2:12][CH2:13][C:14]1([CH2:18][CH2:19]1)[NH2:15])=[O:16])[CH3:17]|US20160100579A1_0372
3.1.2|[c:6]:[c&H0&+0&D3:5](:[c:4])-B1-O-C(-C)(-C)-C(-C)(-C)-O-1.[c:3]:[c&H0&+0&D3:2](:[s:1])-Cl>>[c:6]:[c&H0&+0&D3:5](:[c:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|CC1(OB(OC1(C)C)[c:1]1[cH:2][c:3]([cH:4][cH:5][c:6]1[CH3:7])[C:8](=[O:9])[OH:10])C.[CH3:11][C:12]([CH3:13])([CH3:14])[NH:15][C:16](=[O:17])[c:18]1[s:19][c:20]([cH:21][c:22]1[CH:23]=[O:24])Cl>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.COCCOC.O=C(O[Na])O[Na].CCO.[NH4+].O.[Cl-]>[CH3:7][c:6]1[cH:5][cH:4][c:3]([cH:2][c:1]1-[c:20]1[cH:21][c:22]([c:18]([s:19]1)[C:16](=[O:17])[NH:15][C:12]([CH3:11])([CH3:13])[CH3:14])[CH:23]=[O:24])[C:8](=[O:9])[OH:10]|EP2913333A1_0083
4.1.45|[C:7]-[C&H0&+0&D3:6](-Cl)=O.[C:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D3:4]:1-[C:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][c:10]([c:11]1[NH:12][CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)-[c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1[C:26]#[N:27])[NH2:28].O=[C:29](Cl)[CH2:30][Cl:31]>CCN(CC)CC.ClCCl.O.[Na+].[OH-]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][c:10]2[n:28][c:29]([n:12]([c:11]12)[CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)-[c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1[C:26]#[N:27])[CH2:30][Cl:31]|US20100278835A1_0644
2.6.9|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[N&H0&+0&D2:3]-[C:2].[O&H1&+0&D1:1]-C>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](=[O&H0&+0&D1:1])-[N&H1&+0&D2:3]-[C:2]|C[OH:1].[C:2](=[N:3][CH:4]1[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1)=[N:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1>CCOCC.CS(C)=O.O=C(O)C(=O)O.O=C(O)C(F)(F)F>[O:1]=[C:2]([NH:3][CH:4]1[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1)[NH:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1|US07585983B2_0183
1.2.18|[C:7]-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C:7]-[C&H0&+0&D3:6](-[C:5])=[C&H0&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[N:1]#[C:2][CH:3]1[CH2:4][S:5][CH2:6][C:7]1=O.[NH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[NH2:15]>CC(=O)O>[N:1]#[C:2][C:3]1[CH2:4][S:5][CH2:6][C:7]=1[NH:15][c:14]1[cH:13][cH:12][cH:11][cH:10][c:9]1[NH2:8]|EP0214009A2_0042
1.2.18|[C:7]-[C&H0&+0&D3:6](-[C&H1&+0&D3:5](-[C:4])-[C:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:1]-[C:2])=[C&H0&+0&D3:5](-[C:4])-[C:3]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([NH2:7])=[O:8].O=[C:9]1[CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[C:15]1=[CH:16][CH2:17][CH2:18][CH2:19][CH2:20]1>O.Cc1ccccc1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](=[O:8])[NH:7][C:9]1[CH2:10][CH2:11][CH2:12][CH2:13][C:14]=1[C:15]1=[CH:16][CH2:17][CH2:18][CH2:19][CH2:20]1|US20170226120A1_0225
10.4.10|[C:6]-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[C:3].[O&H1&+0&D1:2]-[O&H1&+0&D1:1]>>[C:6]-[C&H1&+0&D3:5](-[O&H1&+0&D1:1])-[C&H1&+0&D3:4](-[C:3])-[O&H1&+0&D1:2]|[CH3:1][CH:2]([Cl:3])[CH2:4][O:5][P:6]1([CH2:7][CH:8]=[CH:9][CH2:10]1)=[O:11].[OH:12][OH:13]>O=[Os-2](=O)(O)(O)(O)O.O.[K+].[K+]>[CH3:1][CH:2]([Cl:3])[CH2:4][O:5][P:6]1([CH2:10][CH:9]([CH:8]([CH2:7]1)[OH:12])[OH:13])=[O:11]|US07560578B2_0042
5.5.1|[C:6]-[C&H1&+0&D2:5]=[O&H0&+0&D1:4].[O&H1&+0&D1:3]-[C:2]-[C&H2&+0&D2:1]-O>>[C:6]-[C&H1&+0&D3:5]1-[O&H0&+0&D2:4]-[C&H2&+0&D2:1]-[C:2]-[O&H0&+0&D2:3]-1|[O:1]=[C:2]([O:3][CH:4]([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[CH:17]1[C:18](=[CH:19][S:20][C@@H:21]2[CH:22]([C:23]([N:24]21)=[O:25])[NH:26][C:27](=[O:28])[CH2:29][c:30]1[cH:31][cH:32][cH:33][s:34]1)[CH:35]=[O:36].O[CH2:37][CH2:38][OH:39]>Cc1ccccc1S(=O)(=O)O.c1ccccc1.O>[O:28]=[C:27]([CH2:29][c:30]1[cH:31][cH:32][cH:33][s:34]1)[NH:26][CH:22]1[C:23]([N:24]2[CH:17]([C:18](=[CH:19][S:20][C@H:21]12)[CH:35]1[O:36][CH2:37][CH2:38][O:39]1)[C:2](=[O:1])[O:3][CH:4]([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1)=[O:25]|US20170276671A1_0078
2.1.26|[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-O.[c:3]:[n&H0&+0&D3:2](:[c:1])-C(=O)-n1:c:n:c:c:1>>[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][CH:3]=[CH:4][CH2:5][CH:6]=[CH:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:19][c:20]1[cH:21][cH:22][c:23]([o:24]1)[C:25](=[O:26])O.O=C(n1cncc1)[n:27]1[cH:28][n:29][cH:30][cH:31]1>O=C=O.C1CCOC1>[CH3:1][CH2:2][CH:3]=[CH:4][CH2:5][CH:6]=[CH:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:19][c:20]1[cH:21][cH:22][c:23]([o:24]1)[C:25](=[O:26])[n:27]1[cH:31][cH:30][n:29][cH:28]1|US20190233402A1_0232
4.1.45|[C:7]-[C&H0&+0&D3:6](=N)-O-C.[C:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D3:4]:1-[C:5]|Cl.Cl.CO[C:1](=N)[CH2:2][CH:3]1[CH2:4][CH2:5][N:6]([CH2:7][CH2:8]1)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[NH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[NH:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][o:29]1>CC(=O)O>[cH:13]1[cH:14][cH:15][c:10]([cH:11][cH:12]1)[CH2:9][N:6]1[CH2:7][CH2:8][CH:3]([CH2:4][CH2:5]1)[CH2:2][c:1]1[n:16][c:17]2[cH:18][cH:19][cH:20][cH:21][c:22]2[n:23]1[CH2:24][c:25]1[cH:26][cH:27][cH:28][o:29]1|US20050032829A1_0549
1.3.7|[N&H2&+0&D1:7]-[C:6]-[C:5]-[O&H0&+0&D2:4]-C.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[N&H1&+0&D2:7](-[C:6]-[C:5]-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([NH2:4])[C:5](=[O:6])[O:7]C.[O:8]=[c:9]1[c:10]([n:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[n:18]1[C@@H:19]1[CH2:20][C@@H:21]2[CH2:22][CH2:23][C@H:24]([CH2:25]1)[N:26]2[CH:27]1[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1)Cl>Cl>[CH3:1][C:2]([CH3:3])([NH:4][c:10]1[n:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[n:18]([c:9]1=[O:8])[C@@H:19]1[CH2:20][C@@H:21]2[CH2:22][CH2:23][C@H:24]([CH2:25]1)[N:26]2[CH:27]1[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[C:5](=[O:6])[OH:7]|US20200123151A1_0338
7.3.5|[C:7]-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D3:4](-[C:3])=[N&H0&+0&D2:2]-[c:1]>>[C:7]-[C@&H1&+0&D3:6](-[C:5])-[C@@&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][N:10]1[C:11]([CH:12]2[CH2:13][CH2:14][CH2:15][C:16]2=[N:17][c:18]2[cH:19][cH:20][cH:21][cH:22][c:23]21)=[O:24]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][N:10]1[C:11]([C@H:12]2[CH2:13][CH2:14][CH2:15][C@H:16]2[NH:17][c:18]2[cH:19][cH:20][cH:21][cH:22][c:23]21)=[O:24]|EP0757681B1_0383
1.2.17|[C:6]-[C&H0&+0&D2:5]#[C&H0&+0&D2:4]-[c:3]:[c:2]-[N&H1&+0&D2:1]-C(=O)-O-C(-C)(-C)-C>>[C:6]-[c&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1|[CH3:1][C:2]([CH3:3])([CH2:4][C@@:5]([OH:6])([CH2:7][C:8]#[C:9][c:10]1[cH:11][c:12]([n:13][cH:14][c:15]1[NH:16]C(=O)OC(C)(C)C)[S:17]([CH3:18])(=[O:19])=[O:20])[C:21]([F:22])([F:23])[F:24])[c:25]1[cH:26][cH:27][c:28]([cH:29][c:30]1[S:31]([CH3:32])(=[O:33])=[O:34])[Cl:35]>>[CH3:32][S:31](=[O:33])(=[O:34])[c:30]1[cH:29][c:28]([cH:27][cH:26][c:25]1[C:2]([CH3:1])([CH3:3])[CH2:4][C@@:5]([OH:6])([CH2:7][c:8]1[cH:9][c:10]2[cH:11][c:12]([n:13][cH:14][c:15]2[nH:16]1)[S:17]([CH3:18])(=[O:19])=[O:20])[C:21]([F:22])([F:23])[F:24])[Cl:35]|US09796713B2_0095
1.6.2|[C:7]-[C&H1&+0&D3:6](-[C:5]-[O&H0&+0&D2:4]-C)-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H1&+0&D3:6](-[C:5]-[O&H1&+0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][CH2:3][CH2:4][CH:5](Br)[C:6](=[O:7])[O:8]C.[CH3:9][O:10][c:11]1[cH:12][nH:13][c:14]([cH:15][c:16]1-[c:17]1[cH:18][c:19]([cH:20][cH:21][c:22]1[C:23]([CH3:24])=[O:25])[Cl:26])=[O:27]>O.Cl.CN(C)C=O.[NaH]>[CH3:9][O:10][c:11]1[cH:12][n:13]([c:14]([cH:15][c:16]1-[c:17]1[cH:18][c:19]([cH:20][cH:21][c:22]1[C:23]([CH3:24])=[O:25])[Cl:26])=[O:27])[CH:5]([CH2:4][CH2:3][O:2][CH3:1])[C:6](=[O:7])[OH:8]|US10005728B2_0587
4.1.22|[C:7]-[N&H2&+0&D1:6].[n:5]:[c&H0&+0&D3:4](:[c:3]-[C:2]-[C&H2&+0&D2:1]-Cl)-Cl>>[C:7]-[N&H0&+0&D3:6]1-[C&H2&+0&D2:1]-[C:2]-[c:3]:[c&H0&+0&D3:4]-1:[n:5]|Cl.[CH3:1][c:2]1[n:3][c:4]2[n:5][cH:6][n:7][n:8]2[c:9]([c:10]1[CH2:11][CH2:12]Cl)Cl.[CH3:13][CH2:14][CH2:15][CH2:16][NH2:17]>CCN(CC)CC.CCO>[CH3:13][CH2:14][CH2:15][CH2:16][N:17]1[CH2:12][CH2:11][c:10]2[c:2]([n:3][c:4]3[n:5][cH:6][n:7][n:8]3[c:9]21)[CH3:1]|US20070270588A1_0083
2.1.26|[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[c:3]:[n&H0&+0&D3:2](:[c:1])-C(=O)-n1:c:n:c:c:1>>[C:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][C:3]12[CH2:4][CH2:5][C:6]([CH:7]=[C:8]1[c:9]1[c:10]([cH:11][c:12]([c:13]([c:14]1[Cl:15])[Cl:16])[O:17][CH2:18][C:19](=[O:20])O)[CH2:21]2)=[O:22].O=C(n1ccnc1)[n:23]1[cH:24][cH:25][n:26][cH:27]1>C1CCOC1>[CH3:1][CH2:2][C:3]12[CH2:4][CH2:5][C:6]([CH:7]=[C:8]1[c:9]1[c:10]([cH:11][c:12]([c:13]([c:14]1[Cl:15])[Cl:16])[O:17][CH2:18][C:19](=[O:20])[n:23]1[cH:24][cH:25][n:26][cH:27]1)[CH2:21]2)=[O:22]|US20190210973A1_0617
4.1.90|[c:6]:[n&H0&+0&D2:5]:[c:4]-[N&H1&+0&D2:3]-[C&H1&+0&D2:2]=[N&H0&+0&D2:1]-O>>[c:6]:[n&H0&+0&D3:5]1:[n&H0&+0&D2:1]:[c&H1&+0&D2:2]:[n&H0&+0&D2:3]:[c:4]:1|O[N:1]=[CH:2][NH:3][c:4]1[n:5][c:6]([cH:7][n:8][c:9]1[Br:10])[Br:11]>O.[Na+].[O-]C(=O)O.O=P(O)(O)O>[Br:11][c:6]1[cH:7][n:8][c:9]([c:4]2[n:3][cH:2][n:1][n:5]12)[Br:10]|US10287286B2_0910
7.5.1|[C&H3&D1:6]-[C&H1&+0&D3:5](-[N:4])-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&D1:6]-[C@&H1&+0&D3:5](-[N:4])-[C@@&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]|[CH3:1][CH:2]([CH3:3])[Si:4]([O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1[CH3:12])[C:13](=[O:14])[CH:15]([CH3:16])[N:17]1[CH2:18][CH2:19][C:20]([CH2:21][CH2:22]1)([OH:23])[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30])([CH:31]([CH3:32])[CH3:33])[CH:34]([CH3:35])[CH3:36]>CCO.[Na+].[BH4-]>[CH3:12][c:11]1[cH:10][c:9]([cH:8][cH:7][c:6]1[O:5][Si:4]([CH:31]([CH3:32])[CH3:33])([CH:34]([CH3:35])[CH3:36])[CH:2]([CH3:1])[CH3:3])[C@@H:13]([OH:14])[C@@H:15]([CH3:16])[N:17]1[CH2:18][CH2:19][C:20]([CH2:21][CH2:22]1)([OH:23])[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30]|US06835559B2
7.5.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C&H3&D1:6]-[C@@&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C@&H1&+0&D3:3](-[C:2])-[C:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH2:6][NH:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[C:16]([CH3:17])=[O:18]>CCN(CC)CC.ClCCl.[Ru]>[CH3:1][O:2][C:3](=[O:4])[C@@H:5]([CH2:6][NH:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[C@@H:16]([CH3:17])[OH:18]|EP1908845A1_0068
1.8.6|[C&H3&+0&D1:6]-I.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[c:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[c:1]|Cl.[CH3:1][CH2:2][CH2:3][c:4]1[n:5][c:6]([c:7]2[c:8]([nH:9][c:10]([n:11][n:12]12)[NH2:13])=[S:14])[CH3:15].[CH3:16]I>O[Na]>[CH3:15][c:6]1[n:5][c:4]([n:12]2[n:11][c:10]([n:9][c:8]([c:7]12)[S:14][CH3:16])[NH2:13])[CH2:3][CH2:2][CH3:1]|US20170239249A1_0472
1.8.6|[C&H3&+0&D1:6]-I.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[n:3]):[n&H1&+0&D2:2]:[c:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[n:3]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][c:2]1[nH:3][c:4]([nH:5][c:6]([c:7]1[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)=[O:15])=[S:16].[CH3:17]I>O.CCO.O[Na]>[CH3:1][c:2]1[n:3][c:4]([nH:5][c:6]([c:7]1[CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)=[O:15])[S:16][CH3:17]|US20200087283A1_0688
1.7.14|[C&H3&+0&D1:6]-I.[O&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[n:1]>>[C&H3&+0&D1:6]-[O&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[n:1]|[CH3:1]I.[CH3:2][O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[O:10][c:11]1[c:12]([n:13]([nH:14][c:15]1=[O:16])[CH3:17])[NH2:18]>CN(C)C=O.O=C(O[Cs])O[Cs]>[CH3:2][O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[O:10][c:11]1[c:12]([n:13]([n:14][c:15]1[O:16][CH3:1])[CH3:17])[NH2:18]|EP2266990B1_0177
1.9.11|[O&H0&-&D1:7]-[P&H0&+0&D3:6](-[O:5])-[O:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O&H0&+0&D1:7]=[P&H0&+0&D4:6](-[O:5])(-[O:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][NH:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)Br.[CH3:14][CH2:15][O:16][P:17]([O-:18])[O:19][CH2:20][CH3:21]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.Cc1ccccc1.CCN(CC)CC.CCOCC.[Pd].[Pd]>[CH3:1][O:2][C:3](=[O:4])[CH2:5][NH:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[P:17](=[O:18])([O:16][CH2:15][CH3:14])[O:19][CH2:20][CH3:21]|US09381508B2_0665
7.6.1|[C:7]-[C&H0&+0&D3:6](-[C:5]-[O&H0&+0&D2:4]-C-C)=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C:7]-[C&H1&+0&D3:6](-[C:5]-[O&H1&+0&D1:4])-[C&H1&+0&D3:3](-[c:2])-[c:1]|CC[O:1][C:2](=[O:3])[C:4]1=[C:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[CH:12]1[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[O:19][CH3:20])[c:21]1[cH:22][cH:23][c:24]2[O:25][CH2:26][O:27][c:28]2[cH:29]1>CCO.[Pd]>[CH3:20][O:19][c:16]1[cH:15][cH:14][c:13]([cH:18][cH:17]1)[CH:12]1[c:11]2[cH:10][cH:9][cH:8][cH:7][c:6]2[CH:5]([CH:4]1[C:2](=[O:3])[OH:1])[c:21]1[cH:22][cH:23][c:24]2[O:25][CH2:26][O:27][c:28]2[cH:29]1|US06274737B1
8.8.18|[C&H2&+0&D2:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1>>[c&H1&+0&D2:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])-[n:11]1[c:12]([cH:13][c:14]2[CH2:15][CH2:16][CH2:17][CH2:18][c:19]21)-[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>Cc1ccccc1C.[Pd]>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])-[n:11]1[c:19]2[cH:18][cH:17][cH:16][cH:15][c:14]2[cH:13][c:12]1-[c:20]1[cH:25][cH:24][cH:23][cH:22][cH:21]1|US20060142323A1_0215
1.8.6|[C&H3&+0&D1:6]-I.[N:5]-[C&H0&+0&D3:4](=[S&H0&+0&D1:3])-[N&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:3]-[C&H0&+0&D3:4](-[N:5])=[N&H0&+0&D2:2]-[c:1]|[CH3:1]I.[NH2:2][CH2:3][CH2:4][NH:5][C:6](=[S:7])[NH:8][c:9]1[c:10]([cH:11][cH:12][cH:13][c:14]1[Cl:15])[Cl:16]>O.Cl.CCO.O[Na]>[CH3:1][S:7][C:6](=[N:8][c:9]1[c:10]([cH:11][cH:12][cH:13][c:14]1[Cl:15])[Cl:16])[NH:5][CH2:4][CH2:3][NH2:2]|US06455566B1
1.9.3|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[C:4]-[#50&H1&+0&D3:3](-[C:2])-[C:1]>>[C&H1&+0&D2:7](=[C&H1&+0&D2:6]-[C:5])-[#50&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH:1]#[C:2][CH2:3][CH:4]([O:5][Si:6]([CH2:7][CH3:8])([CH2:9][CH3:10])[CH2:11][CH3:12])[C:13](=[CH2:14])[CH2:15][CH2:16][CH3:17].[CH3:18][CH2:19][CH2:20][CH2:21][SnH:22]([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:27][CH2:28][CH2:29][CH3:30]>>[CH2:14]=[C:13]([CH2:15][CH2:16][CH3:17])[CH:4]([CH2:3][CH:2]=[CH:1][Sn:22]([CH2:23][CH2:24][CH2:25][CH3:26])([CH2:27][CH2:28][CH2:29][CH3:30])[CH2:21][CH2:20][CH2:19][CH3:18])[O:5][Si:6]([CH2:7][CH3:8])([CH2:9][CH3:10])[CH2:11][CH3:12]|US10322995B2_0321
3.9.79|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([CH2:11]1)=[O:12].[Br:13][c:14]1[cH:15][n:16][c:17]([n:18][cH:19]1)I>CCCC[Li].Cc1ccccc1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([CH2:11]1)([OH:12])[c:17]1[n:18][cH:19][c:14]([cH:15][n:16]1)[Br:13]|US10865191B2_0533
1.2.14|[C:6]-[N&H2&+0&D1:5].[c:4]-[C&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[C:6]-[N&H1&+0&D2:5]-[C&H2&+0&D2:2]-[C@&H1&+0&D3:3](-[c:4])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][c:3]1[cH:4][c:5]2[CH2:6][CH:7]([CH2:8][c:9]2[cH:10][c:11]1[CH2:12][CH3:13])[NH2:14].[O:15]=[c:16]1[cH:17][cH:18][c:19]2[c:20]([nH:21]1)[c:22]([cH:23][cH:24][c:25]2[CH:26]1[CH2:27][O:28]1)[O:29][CH2:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1>[O-]C([O-])=O>[CH3:1][CH2:2][c:3]1[cH:4][c:5]2[CH2:6][CH:7]([CH2:8][c:9]2[cH:10][c:11]1[CH2:12][CH3:13])[NH:14][CH2:27][C@H:26]([OH:28])[c:25]1[cH:24][cH:23][c:22]([c:20]2[nH:21][c:16]([cH:17][cH:18][c:19]21)=[O:15])[O:29][CH2:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1|US20200268688A1_0618
1.8.6|[C&H3&+0&D1:6]-I.[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:1]/[C&H0&+0&D3:3](-[N:2])=[N&H0&+0&D2:4]\[C:5]|[CH3:1][CH:2]([CH3:3])[C@@H:4]([NH:5][C:6](=[S:7])[NH:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[N:19]1[CH2:20][CH2:21][CH:22]([CH2:23][CH2:24]1)[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[Cl:31].[CH3:32]I>CCOCC.CC#N.[O-]C([O-])=O.[K+].[K+]>[CH3:1][CH:2]([CH3:3])[C@@H:4]([NH:5]/[C:6](=[N:8]/[C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[S:7][CH3:32])[C:17](=[O:18])[N:19]1[CH2:20][CH2:21][CH:22]([CH2:23][CH2:24]1)[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[Cl:31]|US10111437B2_0665
9.7.262|[C:6]-[C&H0&+0&D3:5](-[C:4])=[O&H0&+0&D1:3].[N&H0&D1:2]#[C&H0&+0&D2:1]-[#11]>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[O&H1&+0&D1:3])-[C&H0&+0&D2:1]#[N&H0&D1:2]|[N:1]#[C:2][Na].[O:3]=[C:4]([CH2:5][Cl:6])[CH2:7][C:8](=[O:9])[OH:10]>O.[Na+].Cl.[C-]#N>[N:1]#[C:2][C:4]([OH:3])([CH2:5][Cl:6])[CH2:7][C:8](=[O:9])[OH:10]|US05315015A
1.8.6|[C&H3&+0&D1:6]-I.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[n:3]):[n&H1&+0&D2:2]:[n:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[n:3]):[n&H0&+0&D2:2]:[n:1]|[CH3:1][CH2:2][CH:3]([CH3:4])[c:5]1[n:6][nH:7][c:8]([n:9]([c:10]1=[O:11])[NH2:12])=[S:13].[CH3:14]I>O.O[Na]>[CH3:1][CH2:2][CH:3]([CH3:4])[c:5]1[n:6][n:7][c:8]([n:9]([c:10]1=[O:11])[NH2:12])[S:13][CH3:14]|US20200317676A1_0179
1.8.6|[C&H3&+0&D1:6]-I.[C:5]-[C&H0&+0&D3:4](=[S&H0&+0&D1:3])-[N&H1&+0&D2:2]-[C:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:3]-[C&H0&+0&D3:4](-[C:5])=[N&H0&+0&D2:2]-[C:1]|[CH3:1][C:2]1([NH:3][C:4]([CH2:5][S:6]1)=[S:7])[CH3:8].[CH3:9]I>CN(C)C=O.[H][H].[Na]>[CH3:1][C:2]1([N:3]=[C:4]([CH2:5][S:6]1)[S:7][CH3:9])[CH3:8]|US20180327391A1_0924
1.7.17|[C:6]-[O&H1&+0&D1:5].[C:4]-[C&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[C:6]-[O&H0&+0&D2:5]-[C&H2&+0&D2:2]-[C@&H1&+0&D3:3](-[C:4])-[O&H1&+0&D1:1]|[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][N:14]([CH2:15][CH2:16]1)[CH2:17][CH:18]1[CH2:19][O:20]1.[OH:21][CH2:22][C:23]([F:24])([F:25])[F:26]>O=C(O[Cs])O[Cs]>[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][N:14]([CH2:15][CH2:16]1)[CH2:17][C@@H:18]([OH:20])[CH2:19][O:21][CH2:22][C:23]([F:24])([F:25])[F:26]|EP2018862A1_0121
1.8.6|[C&H3&+0&D1:6]-I.[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](=[S&H0&+0&D1:2])-[S:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:2]-[C&H0&+0&D3:3](-[S:1])=[N&H0&+0&D2:4]-[C:5]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[nH:7][c:8]([c:9]([c:10]2[cH:11]1)/[CH:12]=[C:13]1\[S:14][C:15]([NH:16][C:17]1=[O:18])=[S:19])[CH3:20].[CH3:21]I>CC(C)N(CC)C(C)C.CO>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[nH:7][c:8]([c:9]([c:10]2[cH:11]1)/[CH:12]=[C:13]1\[S:14][C:15](=[N:16][C:17]1=[O:18])[S:19][CH3:21])[CH3:20]|US20040097566A1_0510
7.5.1|[C:6]-[C&H1&+0&D3:5](-[F&H0&D1:4])-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C:6]-[C@@&H1&+0&D3:5](-[F&H0&D1:4])-[C@@&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]|[N:1]#[C:2][c:3]1[cH:4][n:5][cH:6][c:7]([cH:8]1)[O:9][c:10]1[cH:11][cH:12][c:13]([c:14]2[c:15]1[CH2:16][CH:17]([C:18]2=[O:19])[F:20])[S:21](=[O:22])(=[O:23])[C:24]([F:25])([F:26])[F:27]>Cc1ccc(cc1)S(=O)(=O)[N-][C@H](c1ccccc1)[C@H](N)c1ccccc1.Cc1ccc(cc1)C(C)C.CCN(CC)CC.O=CO.ClCCl.Cl[Ru+].O>[N:1]#[C:2][c:3]1[cH:4][n:5][cH:6][c:7]([cH:8]1)[O:9][c:10]1[cH:11][cH:12][c:13]([c:14]2[c:15]1[CH2:16][C@H:17]([C@H:18]2[OH:19])[F:20])[S:21](=[O:22])(=[O:23])[C:24]([F:25])([F:26])[F:27]|EP3417851B1_0913
1.2.14|[C:6]-[N&H2&+0&D1:5].[C:4]-[C@&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[C:6]-[N&H1&+0&D2:5]-[C&H2&+0&D2:2]-[C&H1&+0&D3:3](-[C:4])-[O&H1&+0&D1:1]|[NH2:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[F:9][c:10]1[cH:11][cH:12][c:13]2[c:14]([cH:15]1)[o:16][n:17][c:18]2-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[O:25][CH2:26][C@H:27]1[CH2:28][O:29]1>Cl.CO.CCO.ClC(Cl)Cl>[OH:29][CH:27]([CH2:26][O:25][c:22]1[cH:23][cH:24][c:19]([cH:20][cH:21]1)-[c:18]1[n:17][o:16][c:14]2[cH:15][c:10]([cH:11][cH:12][c:13]21)[F:9])[CH2:28][NH:1][CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|US06699860B2
9.7.262|[C:6]-[C&H0&+0&D3:5](-[C:4])=[O&H0&+0&D1:3].[N&H0&D1:2]#[C&H0&+0&D2:1]-[#19]>>[C:6]-[C&H0&+0&D4:5](-[C:4])(-[O&H1&+0&D1:3])-[C&H0&+0&D2:1]#[N&H0&D1:2]|[CH3:1][CH:2]1[CH2:3][CH:4]([CH2:5][C:6]([CH2:7]1)=[O:8])[CH3:9].[N:10]#[C:11][K]>O.O=S(O)O[Na]>[CH3:1][CH:2]1[CH2:3][CH:4]([CH2:5][C:6]([CH2:7]1)([OH:8])[C:11]#[N:10])[CH3:9]|US04921638A
1.8.6|[C&H3&+0&D1:6]-I.[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:1]-[C&H0&+0&D3:3](-[N:2])=[N&H0&+0&D2:4]-[C:5]|[CH3:1][O:2][C:3](=[O:4])[NH:5][C:6](=[S:7])[NH:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[NH:15][C:16]([CH3:17])=[O:18])[O:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[CH3:26]I>[Na+].C[O-].CN(C)C=O>[CH3:1][O:2][C:3](=[O:4])[N:5]=[C:6]([NH:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[NH:15][C:16]([CH3:17])=[O:18])[O:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[S:7][CH3:26]|US20180339983A1_0720
3.9.79|[O&H0&+0&D1:7]=[C&H0&+0&D3:6](-[c:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[O&H1&+0&D1:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[s:9][c:10]1-[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3[C:17]([c:18]12)=[O:19].I[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[O:26][CH2:27][CH2:28][N:29]1[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1>CCCCC.CCOCC.CC(C)(C)[Li].C1CCOC1>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[s:9][c:10]1-[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3[C:17]([c:18]21)([OH:19])[c:20]1[cH:25][cH:24][c:23]([cH:22][cH:21]1)[O:26][CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1|EP1506959A2_0319
1.8.6|[C&H3&+0&D1:6]-I.[C:5]-[C&H0&+0&D3:4](=[S&H0&+0&D1:3])-[N&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:3]-[C&H0&+0&D3:4](-[C:5])=[N&H0&+0&D2:2]-[c:1]|[CH3:1]I.[O:2]=[C:3]1[CH2:4][C:5]([NH:6][c:7]2[cH:8][cH:9][c:10]([cH:11][c:12]2[N:13]1[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[Cl:20])=[S:21]>CO.O[Na]>[CH3:1][S:21][C:5]1[CH2:4][C:3]([N:13]([c:12]2[cH:11][c:10]([cH:9][cH:8][c:7]2[N:6]=1)[Cl:20])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)=[O:2]|US20120022056A1_0236
4.1.45|[N&H0&+0&D1:6]#[C&H0&+0&D2:5]-Br.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[N&H2&+0&D1:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[NH2:11])[NH2:12].[N:13]#[C:14]Br>O>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:10][c:9]2[nH:11][c:14]([n:12][c:8]2[cH:7][cH:6]1)[NH2:13]|US08859773B2_0327
1.2.5|[C:7]-[N&H2&+0&D1:6].[C:5]-[C&H0&+0&D3:4](-[C&H1&+0&D3:3](-[C:2])-[O:1])=O>>[C:7]-[N&H1&+0&D2:6]-[C@&H1&+0&D3:4](-[C:5])-[C@&H1&+0&D3:3](-[C:2])-[O:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][C:9]([CH:10]([CH2:11]1)[O:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)=O.[NH2:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>CO.CCO.c1ccsc1.[H][H].[Pd]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:11][C@H:10]([C@H:9]([CH2:8][CH2:7]1)[NH:20][CH2:21][c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1)[O:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US20130197008A1_0302
1.7.7|[C&H3&D1:6]-[C@@&H1&+0&D3:5](-[C:4]-[O&H0&+0&D2:3]-C)-O.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[C@@&H1&+0&D3:5](-[O&H0&+0&D2:2]-[c:1])-[C:4]-[O&H1&+0&D1:3]|C[O:1][C:2](=[O:3])[C@H:4]([CH3:5])O.[OH:6][c:7]1[c:8]([cH:9][c:10]([cH:11][c:12]1[Br:13])-[c:14]1[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[c:21]([c:22]2[s:23][c:24]3[cH:25][cH:26][cH:27][cH:28][c:29]3[c:30]21)[Br:31])[Br:32]>BrBr>[CH3:5][C@@H:4]([O:6][c:7]1[c:12]([cH:11][c:10]([cH:9][c:8]1[Br:32])-[c:14]1[c:30]2[c:29]3[cH:28][cH:27][cH:26][cH:25][c:24]3[s:23][c:22]2[c:21]([c:20]2[cH:19][cH:18][cH:17][cH:16][c:15]21)[Br:31])[Br:13])[C:2](=[O:3])[OH:1]|US20110166117A1_0855
1.8.6|[C&H3&+0&D1:6]-I.[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](=[S&H0&+0&D1:2])-[c:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:2]-[C&H0&+0&D3:3](-[c:1])=[N&H0&+0&D2:4]-[C:5]|[CH3:1]I.[CH3:2][c:3]1[n:4][n:5][c:6]2[CH2:7][NH:8][C:9]([c:10]3[cH:11][c:12]([cH:13][cH:14][c:15]3-[n:16]12)[Cl:17])=[S:18]>O.CO.O[Na]>[CH3:2][c:3]1[n:4][n:5][c:6]2[CH2:7][N:8]=[C:9]([c:10]3[cH:11][c:12]([cH:13][cH:14][c:15]3-[n:16]21)[Cl:17])[S:18][CH3:1]|US20200239486A1_0457
1.7.14|[C&H3&+0&D1:6]-I.[O&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[c:1]>>[C&H3&+0&D1:6]-[O&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[c:1]|[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][c:6]2[cH:7][c:8]([nH:9][cH:10][c:11]12)=[O:12].[CH3:13]I>c1ccccc1.[O-]C([O-])=O.[Ag+].[Ag+]>[CH3:13][O:12][c:8]1[cH:7][c:6]2[CH2:5][CH2:4][CH2:3][C:2]([c:11]2[cH:10][n:9]1)=[O:1]|US20200377509A1_0510
3.9.6|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:7]-[C&H0&+0&D4:6](-[O&H1&+0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[S:2](=[O:3])([NH:4][CH2:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[O:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.I[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>[NH4+].[Cl-].BrCCBr.C1CCOC1.[Mg]>[O:1]=[S:2](=[O:3])([NH:4][CH2:5][C:6]([OH:7])([c:28]1[cH:33][cH:32][cH:31][cH:30][cH:29]1)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[O:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|US08575160B2_0235
9.7.264|[F&H0&D1:5]-[C&H0&+0&D4:4](-[F&H0&D1:3])(-Cl)-C(=O)-c1:c:c:c:c:c:1.[O&H1&+0&D1:2]-[c:1]>>[F&H0&D1:5]-[C&H1&+0&D3:4](-[F&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[Br:10])[OH:11].O=C(c1ccccc1)[C:12]([F:13])([F:14])Cl>>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[Br:10])[O:11][CH:12]([F:13])[F:14]|US10822338B2_0192
3.9.79|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]1[CH2:3][CH2:4][C:5]2([CH2:6][CH2:7]1)[O:8][CH2:9][CH2:10][O:11]2.[F:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1I>CCCC[Li].O=C(O)O[Na].C1CCOC1>[OH:1][C:2]1([CH2:3][CH2:4][C:5]2([CH2:6][CH2:7]1)[O:8][CH2:9][CH2:10][O:11]2)[c:18]1[cH:17][cH:16][cH:15][cH:14][c:13]1[F:12]|US07183445B2_0228
7.9.12|[c&H1&+0&D2:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[n&H0&+0&D2:3]:[c:2]:[c:1]:1>>[C&H2&+0&D2:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[N&H1&+0&D2:3]-[c:2]:[c:1]-1|[cH:1]1[cH:2][cH:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[n:10]1>c1ccc2ncccc2n1.Nc1cccnc1.CCCCCC.CCO.O=[Pt]=O>[cH:2]1[cH:1][n:10][c:9]2[CH2:8][CH2:7][CH2:6][NH:5][c:4]2[cH:3]1|US07501386B2_0113
3.9.79|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[C:2]1[CH2:3][N:4]2[CH2:5][CH2:6][CH:7]1[CH2:8]2.I[c:9]1[cH:10][n:11][cH:12][cH:13][n:14]1>O.CCCCC.CCOCC.CC(C)(C)[Li].ClCCl>[OH:1][C:2]1([CH2:3][N:4]2[CH2:5][CH2:6][CH:7]1[CH2:8]2)[c:9]1[cH:10][n:11][cH:12][cH:13][n:14]1|US20200283383A1_0644
3.9.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:7]-[C&H0&+0&D4:6](-[O&H1&+0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)Br.[CH3:11][CH2:12][C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CCOCC.[NH4+].[Cl-].[Mg]>[CH3:11][CH2:12][C:13]([OH:14])([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:9]1[cH:8][cH:7][cH:6][c:5]([cH:10]1)[C:2]([F:1])([F:3])[F:4]|EP0078158A2_0071
3.9.2|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH2:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16].[F:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[CH2:24][n:25]1[cH:26][cH:27][cH:28][c:29]1Br>[NH4+].[Cl-].CCOCC.CC(Br)Br.C1CCOC1.[Mg]>[OH:1][C:2]1([CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH2:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16])[c:29]1[cH:28][cH:27][cH:26][n:25]1[CH2:24][c:23]1[cH:22][cH:21][cH:20][cH:19][c:18]1[F:17]|US10632128B2_0896
1.3.7|[C:7]-[C&H1&+0&D3:6](-[C:5])-[N&H2&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:7]-[C@@&H1&+0&D3:6](-[C:5])-[N&H1&+0&D2:4]-[c&H0&+0&D3:2](:[c:3]):[n:1]|[NH2:1][CH:2]([CH2:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[N:12]1[CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]2[NH:20][C:21]1=[O:22])[C:23](=[O:24])[N:25]1[CH2:26][CH2:27][CH:28]([CH2:29][CH2:30]1)[N:31]1[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1.[Cl:37][c:38]1[cH:39][c:40]([n:41][cH:42][n:43]1)Cl>CC(C)O>[O:22]=[C:21]1[NH:20][c:19]2[cH:18][cH:17][cH:16][cH:15][c:14]2[CH2:13][N:12]1[CH:9]1[CH2:10][CH2:11][N:6]([CH2:7][CH2:8]1)[C:4](=[O:5])[CH2:3][C@H:2]([NH:1][c:40]1[cH:39][c:38]([n:43][cH:42][n:41]1)[Cl:37])[C:23](=[O:24])[N:25]1[CH2:26][CH2:27][CH:28]([CH2:29][CH2:30]1)[N:31]1[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1|US20060089371A1_0500
3.9.4|[C:7]-[C&H1&+0&D3:6](-[C:5])-Cl.[O&H0&+0&D1:4]=[C&H0&+0&D3:3](-[c:2])-[c:1]>>[C:7]-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D4:3](-[O&H1&+0&D1:4])(-[c:2])-[c:1]|[CH3:1][CH:2]1[CH2:3][c:4]2[s:5][cH:6][cH:7][c:8]2[C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)=[O:16].[CH3:17][N:18]1[CH2:19][CH2:20][CH:21]([CH2:22][CH2:23]1)Cl>[NH4+].[Cl-].II.C1CCOC1.[Mg]>[CH3:1][CH:2]1[CH2:3][c:4]2[s:5][cH:6][cH:7][c:8]2[C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21)([OH:16])[CH:21]1[CH2:20][CH2:19][N:18]([CH2:23][CH2:22]1)[CH3:17]|US08796268B2_1095
1.8.10|[C:6]-[S&H1&+0&D1:5].[C:4]-[C@&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[C:6]-[S&H0&+0&D2:5]-[C&H2&+0&D2:2]-[C@&H1&+0&D3:3](-[C:4])-[O&H1&+0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]([CH2:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1)[C@@H:17]1[CH2:18][O:19]1.[CH3:20][CH:21]([CH3:22])[CH2:23][C@H:24]([SH:25])[C:26](=[O:27])[O:28][CH2:29][CH3:30]>CCN(CC)CC.CCO>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]([CH2:10][CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1)[C@@H:17]([OH:19])[CH2:18][S:25][C@@H:24]([CH2:23][CH:21]([CH3:20])[CH3:22])[C:26](=[O:27])[O:28][CH2:29][CH3:30]|US08808703B2_0727
4.2.32|[O&H0&+0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[N&H1&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-O>>[O&H0&+0&D2:6]1-[C&H2&+0&D2:1]-[C:2]-[N&H0&+0&D2:3]=[C&H0&+0&D3:5]-1-[c:4]|[CH3:1][C:2]([CH3:3])([CH2:4]O)[NH:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[Cl:14])[F:15]>O=S(Cl)Cl>[CH3:1][C:2]1([CH2:4][O:7][C:6](=[N:5]1)[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[Cl:14])[F:15])[CH3:3]|US09346957B2_0163
4.1.47|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[N&H0&+0&D2:1](-[O&-])=O>>[C&H3&D1:6]-[n&H0&+0&D3:5]1:[n&H0&+0&D2:1]:[n&H0&+0&D2:2]:[c:3]:[c:4]:1|[Na+].[CH3:1][NH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[NH2:9])[Br:10].[O-][N:11]=O>O.Cl.O[K]>[CH3:1][n:2]1[n:11][n:9][c:8]2[cH:7][c:6]([cH:5][cH:4][c:3]21)[Br:10]|US20200055874A1_1813
4.2.32|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[N&H1&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-O>>[C:6]-[C&H0&+0&D3:5]1-[O&H0&+0&D2:4]-[C&H2&+0&D2:1]-[C:2]-[N&H0&+0&D2:3]=1|[CH3:1][C:2]([CH3:3])([CH2:4]O)[NH:5][C:6](=[O:7])[CH2:8][c:9]1[cH:10][cH:11][c:12]2[O:13][CH2:14][c:15]3[cH:16][cH:17][cH:18][cH:19][c:20]3[C:21]([c:22]2[cH:23]1)=[O:24]>O.O=S(Cl)Cl.ClCCl>[CH3:1][C:2]1([CH2:4][O:7][C:6](=[N:5]1)[CH2:8][c:9]1[cH:10][cH:11][c:12]2[O:13][CH2:14][c:15]3[cH:16][cH:17][cH:18][cH:19][c:20]3[C:21]([c:22]2[cH:23]1)=[O:24])[CH3:3]|EP3575283A1_0150
1.7.17|[C:6]-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[O&H0&+0&D2:3]-1.[O&H1&+0&D1:2]-[c:1]>>[C:6]-[C@@&H1&+0&D3:5](-[C&H2&+0&D2:4]-[O&H0&+0&D2:2]-[c:1])-[O&H1&+0&D1:3]|[CH3:1][O:2][CH2:3][O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C@:11]1([CH2:12][O:13][c:14]2[cH:15][c:16]([cH:17][cH:18][c:19]2[C@H:20]1[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[OH:27])[O:28][CH2:29][O:30][CH3:31])[CH3:32].[F:33][C:34]([F:35])([CH2:36][CH2:37][CH2:38][S:39][CH2:40][CH2:41][O:42][CH2:43][CH:44]1[CH2:45][O:46]1)[C:47]([F:48])([F:49])[F:50]>CC#N.O>[CH3:1][O:2][CH2:3][O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C@:11]1([CH2:12][O:13][c:14]2[cH:15][c:16]([cH:17][cH:18][c:19]2[C@H:20]1[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[O:27][CH2:45][C@@H:44]([OH:46])[CH2:43][O:42][CH2:41][CH2:40][S:39][CH2:38][CH2:37][CH2:36][C:34]([F:35])([F:33])[C:47]([F:48])([F:49])[F:50])[O:28][CH2:29][O:30][CH3:31])[CH3:32]|US10471023B2_0192
4.1.94|[N&H2&+0&D1:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[S&H0&+0&D1:2]=[C&H0&+0&D2:1]=S>>[n&H0&+0&D2:6]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:3]:[c:4]:[c:5]:1)-[S&H1&+0&D1:2]|Cl.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[NH2:9])[NH2:10].[S:11]=[C:12]=S>O.CCO.O[Na]>[CH3:1][O:2][c:3]1[cH:8][c:7]2[nH:9][c:12]([n:10][c:6]2[cH:5][cH:4]1)[SH:11]|US20200247815A1_0809
1.2.14|[C:6]-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[O&H0&+0&D2:3]-1.[N&H2&+0&D1:2]-[c:1]>>[C:6]-[C@@&H1&+0&D3:5](-[C&H2&+0&D2:4]-[N&H1&+0&D2:2]-[c:1])-[O&H1&+0&D1:3]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[OH:8][CH2:9][CH:10]1[CH2:11][O:12]1>>[OH:8][CH2:9][C@H:10]([OH:12])[CH2:11][NH:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1|US20180265497A1_1907
4.1.22|[N&H2&+0&D1:7]-[c:6].[c:5]:[c&H0&+0&D3:4](:[c:3]-[C:2]-[C&H2&+0&D2:1]-Cl)-Cl>>[N&H0&+0&D3:7]1(-[c:6])-[C&H2&+0&D2:1]-[C:2]-[c:3]:[c&H0&+0&D3:4]-1:[c:5]|Cl[CH2:1][CH2:2][c:3]1[n:4][n:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[c:12]1Cl.[CH3:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[NH2:20]>C1COCCO1.CCOCC>[CH3:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[N:20]1[CH2:1][CH2:2][c:3]2[n:4][n:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[c:12]21|US05051508A
3.9.79|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]1[CH2:3][CH2:4][C:5]([CH2:6][CH2:7]1)=[O:8].Br[c:9]1[cH:10][s:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21>O.CCOCC.CCCC[Li]>[CH3:1][N:2]1[CH2:3][CH2:4][C:5]([CH2:6][CH2:7]1)([OH:8])[c:9]1[cH:10][s:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21|EP2606030B1_0025
5.5.1|[O&H0&+0&D1:6]=[C&H1&+0&D2:5]-[c:4].[O&H1&+0&D1:3]-[C:2]-[C&H2&+0&D2:1]-O>>[O&H0&+0&D2:6]1-[C&H1&+0&D3:5](-[O&H0&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-1)-[c:4]|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[CH2:9][CH2:10][n:11]2[cH:12][c:13]([cH:14][c:15]12)[CH:16]=[O:17].[OH:18][CH2:19][CH2:20]O>Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[CH2:9][CH2:10][n:11]2[cH:12][c:13]([cH:14][c:15]12)[CH:16]1[O:17][CH2:20][CH2:19][O:18]1|US07585885B2_0784
3.11.27|[C&H3&+0&D1:6]-[S&+](-C)(-C)=O.[C:5]-[C&H1&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[C:1]>>[C&H2&+0&D2:6]1-[C&H1&+0&D3:4](-[C:5])-[C&H0&+0&D4:3]-1(-[C:2])-[C:1]|[I-].[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]1=[CH:8][CH2:9][CH2:10][CH2:11][C:12]1=[O:13].C[S+](C)([CH3:14])=O>O.CS(C)=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]12[CH2:14][CH:8]1[CH2:9][CH2:10][CH2:11][C:12]2=[O:13]|US20150274664A1_0536
4.1.45|[N&H2&+0&D1:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[O:2]-[C&H0&+0&D4:1](-O-C-C)(-O-C-C)-O-C-C>>[n&H1&+0&D2:6]1:[c:5]:[c:4]:[n&H0&+0&D2:3]:[c&H0&+0&D3:1]:1-[O:2]|[CH3:1][CH2:2][O:3][C:4](OCC)(OCC)OCC.[CH3:5][c:6]1[cH:7][c:8]([n:9][c:10]([c:11]1[NH2:12])[NH2:13])[CH3:14]>CC(C)OC(C)C>[CH3:1][CH2:2][O:3][c:4]1[n:12][c:11]2[c:6]([cH:7][c:8]([n:9][c:10]2[nH:13]1)[CH3:14])[CH3:5]|US20090023763A1_0376
3.9.79|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[n:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[n:3]):[s:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:12][CH2:13]1)=[O:14].Br[c:15]1[n:16][cH:17][cH:18][s:19]1>CCOCC.CCCC[Li].C1CCOC1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:12][CH2:13]1)([OH:14])[c:15]1[n:16][cH:17][cH:18][s:19]1|US10689391B2_0313
3.5.3|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[#30&+].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][c:11]([n:12]2[n:13][cH:14][c:15]([c:16]2[n:17]1)[C:18](=[O:19])[O:20][CH2:21][CH3:22])Cl.[CH3:23][CH:24]([CH3:25])[Zn+].[Br-]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1CCOC1>[CH3:22][CH2:21][O:20][C:18](=[O:19])[c:15]1[cH:14][n:13][n:12]2[c:16]1[n:17][c:9]([cH:10][c:11]2[CH:24]([CH3:23])[CH3:25])-[c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[CH2:2][CH3:1]|US20190375749A1_0220
2.8.5|[C:6]-[C&H2&+0&D2:5]-Br.[C:4]-[C&H0&+0&D3:3](-[O&H1&+0&D1:2])=[S&H0&+0&D1:1]>>[C:6]-[C&H2&+0&D2:5]-[S&H0&+0&D2:1]-[C&H0&+0&D3:3](-[C:4])=[O&H0&+0&D1:2]|[CH3:1][C@@:2]12[CH2:3][CH2:4][C:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@:14]1([C@H:15]2[CH2:16][CH2:17][C@@H:18]1[C:19](=[O:20])[CH2:21]Br)[CH3:22])=[O:23])=[O:24].[OH:25][C:26](=[S:27])[CH2:28][N:29]1[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1>CC(C)=O>[CH3:1][C@@:2]12[CH2:3][CH2:4][C:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@:14]1([C@H:15]2[CH2:16][CH2:17][C@@H:18]1[C:19](=[O:20])[CH2:21][S:27][C:26](=[O:25])[CH2:28][N:29]1[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1)[CH3:22])=[O:23])=[O:24]|US20150141409A1_0706
3.9.79|[O&H0&+0&D1:7]=[C&H0&+0&D3:6](-[c:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[O&H1&+0&D1:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2-[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]12.Br[c:15]1[cH:16][cH:17][cH:18][cH:19][n:20]1>CCCC[Li].C1CCOC1>[OH:1][C:2]1([c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2-[c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]21)[c:15]1[cH:16][cH:17][cH:18][cH:19][n:20]1|US09634268B2_0160
1.7.17|[C:6]-[C@@&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[O&H0&+0&D2:3]-1.[O&H1&+0&D1:2]-[c:1]>>[C:6]-[C&H1&+0&D3:5](-[C&H2&+0&D2:4]-[O&H0&+0&D2:2]-[c:1])-[O&H1&+0&D1:3]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[OH:9].[OH:10][CH2:11][C@@H:12]1[CH2:13][O:14]1>CCO>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[O:9][CH2:13][CH:12]([OH:14])[CH2:11][OH:10]|EP3523301B1_0891
3.11.27|[C&H3&+0&D1:6]-[S&+](-C)(-C)=O.[C:5]-[C&H0&+0&D3:4](-[c:3])=[C&H1&+0&D2:2]-[c:1]>>[C&H2&+0&D2:6]1-[C&H1&+0&D3:2](-[c:1])-[C&H0&+0&D4:4]-1(-[C:5])-[c:3]|[I-].[CH3:1][O:2][C:3](=[O:4])[C:5](=[CH:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)-[c:13]1[cH:14][c:15]([cH:16][c:17]2[cH:18][cH:19][cH:20][n:21][c:22]21)[C:23]([CH3:24])([CH3:25])[S:26]([CH3:27])(=[O:28])=[O:29])[c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[S:36]([CH3:37])(=[O:38])=[O:39].C[S+](C)([CH3:40])=O>O.[Na+].CC(=O)OCC.CS(C)=O.[H-]>[CH3:24][C:23]([CH3:25])([c:15]1[cH:16][c:17]2[cH:18][cH:19][cH:20][n:21][c:22]2[c:13]([cH:14]1)-[c:11]1[cH:10][cH:9][cH:8][c:7]([cH:12]1)[CH:6]1[CH2:40][C:5]1([C:3](=[O:4])[O:2][CH3:1])[c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[S:36]([CH3:37])(=[O:38])=[O:39])[S:26]([CH3:27])(=[O:28])=[O:29]|US08263596B2_0411
3.9.79|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[s:1])-Br>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][CH2:2][CH:3]([CH2:4][CH3:5])[c:6]1[cH:7][c:8]([n:9][n:10]2[c:11]1[n:12][c:13]([c:14]2-[c:15]1[s:16][c:17]([cH:18][c:19]1[CH3:20])Br)[CH3:21])[CH3:22].[O:23]=[C:24]1[CH2:25][CH2:26][O:27][CH2:28][CH2:29]1>CCOC(C)=O.CCCC[Li].C1CCOC1>[CH3:20][c:19]1[cH:18][c:17]([s:16][c:15]1-[c:14]1[c:13]([n:12][c:11]2[c:6]([cH:7][c:8]([n:9][n:10]21)[CH3:22])[CH:3]([CH2:4][CH3:5])[CH2:2][CH3:1])[CH3:21])[C:24]1([CH2:25][CH2:26][O:27][CH2:28][CH2:29]1)[OH:23]|US05217978A
4.2.8|[C:7]-[C&H0&+0&D3:6](-[C:5])=[C&H0&+0&D3:4](-[C:3])-[C:2].[O&H1&+0&D1:1]-O>>[C:7]-[C&H0&+0&D4:6]1(-[C:5])-[O&H0&+0&D2:1]-[C&H0&+0&D4:4]-1(-[C:3])-[C:2]|[CH3:1][CH2:2][C@@H:3]1[CH2:4][CH:5]2[CH:6]3[CH2:7][CH2:8][C:9]4[CH2:10][C:11]5([CH2:12][CH2:13][C:14]=4[C:15]3=[CH:16][CH2:17][C@@:18]2([CH:19]1[C:20]([CH3:21])=[O:22])[CH3:23])[O:24][CH2:25][CH2:26][O:27]5.O[OH:28]>>[CH3:21][C:20](=[O:22])[CH:19]1[C@@H:3]([CH2:4][CH:5]2[CH:6]3[CH2:7][CH2:8][C:9]45[CH2:10][C:11]6([CH2:12][CH2:13][C:14]4([O:28]5)[C:15]3=[CH:16][CH2:17][C@:18]12[CH3:23])[O:24][CH2:25][CH2:26][O:27]6)[CH2:2][CH3:1]|EP0946584B1_0265
1.2.14|[C:6]-[N&H2&+0&D1:5].[C:4]-[C&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[C:6]-[N&H1&+0&D2:5]-[C&H2&+0&D2:2]-[C@@&H1&+0&D3:3](-[C:4])-[O&H1&+0&D1:1]|[CH3:1][O:2][CH2:3][CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH2:12][CH:13]1[CH2:14][O:15]1.[CH3:16][CH:17]([CH3:18])[NH2:19]>CCO>[CH3:1][O:2][CH2:3][CH2:4][c:5]1[cH:10][cH:9][c:8]([cH:7][cH:6]1)[O:11][CH2:12][C@@H:13]([OH:15])[CH2:14][NH:19][CH:17]([CH3:16])[CH3:18]|US20110136843A1_0498
4.1.22|[N&H2&+0&D1:7]-[c:6].[n:5]:[c&H0&+0&D3:4](:[c:3]-[C:2]-[C&H2&+0&D2:1]-Cl)-Cl>>[N&H0&+0&D3:7]1(-[c:6])-[C&H2&+0&D2:1]-[C:2]-[c:3]:[c&H0&+0&D3:4]-1:[n:5]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)-[c:9]1[n:10][c:11]([n:12][c:13]([c:14]1[CH2:15][CH2:16]Cl)Cl)[N:17]1[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1.[NH2:23][c:24]1[cH:25][cH:26][cH:27][n:28][cH:29]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)-[c:9]1[n:10][c:11]([n:12][c:13]2[c:14]1[CH2:15][CH2:16][N:23]2[c:24]1[cH:29][n:28][cH:27][cH:26][cH:25]1)[N:17]1[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1|EP1532148B1_0120
4.3.11|[N:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[N&H1&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-O>>[N:6]-[C&H0&+0&D3:5]1-[S&H0&+0&D2:4]-[C&H2&+0&D2:1]-[C:2]-[N&H0&+0&D2:3]=1|O[CH2:1][CH2:2][NH:3][C:4](=[S:5])[NH:6][c:7]1[cH:8][cH:9][cH:10][c:11]2[cH:12][cH:13][o:14][c:15]21>O.Cl.C>[cH:9]1[cH:10][c:11]2[cH:12][cH:13][o:14][c:15]2[c:7]([cH:8]1)[NH:6][C:4]1=[N:3][CH2:2][CH2:1][S:5]1|US20110118116A1_0421
3.9.2|[O&H0&+0&D1:7]=[C&H0&+0&D3:6](-[c:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O&H1&+0&D1:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([o:5][n:6]1)[C:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.Br[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CCOCC.Br[Mg]c1ccccc1.[Mg]>[CH3:1][c:2]1[cH:3][c:4]([o:5][n:6]1)[C:7]([OH:8])([c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|EP2909189B1_0255
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[O&H1&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[O&H1&D1:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[O:1]=[C:2](O)[CH:3]=[CH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[O:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[CH3:18][NH:19][OH:20].Cl>CCN(CC)CC.CCOC(C)=O.COC(=O)Cl.C1CCOC1.O>[CH3:18][N:19]([OH:20])[C:2](=[O:1])[CH:3]=[CH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[O:11][c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US20190389836A1_0691
2.4.2|[C&H3&D1:6]-[O&H1&+0&D1:5].[C:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:2]=[O&H0&D1:1]>>[C&H3&D1:6]-[O&H0&+0&D2:5]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[N&H1&+0&D2:3]-[C:4]|[CH3:1][CH2:2][CH:3]([CH3:4])[N:5]=[N:6][C:7]([CH3:8])([CH2:9][CH:10]([CH3:11])[CH3:12])[N:13]=[C:14]=[O:15].[CH3:16][OH:17]>O.[NaH]>[CH3:11][CH:10]([CH3:12])[CH2:9][C:7]([CH3:8])([N:6]=[N:5][CH:3]([CH3:4])[CH2:2][CH3:1])[NH:13][C:14](=[O:15])[O:17][CH3:16]|US20130079449A1_0111
2.4.2|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[O:1]=[CH:2][NH:3][c:4]1[cH:5][cH:6][c:7]([c:8]2[CH2:9][CH2:10][CH2:11][CH2:12][c:13]12)[OH:14].[CH3:15][N:16]=[C:17]=[O:18]>CCN(CC)CC.CC(C)=O>[CH3:15][NH:16][C:17](=[O:18])[O:14][c:7]1[cH:6][cH:5][c:4]([c:13]2[CH2:12][CH2:11][CH2:10][CH2:9][c:8]21)[NH:3][CH:2]=[O:1]|US20090306039A1_0084
2.3.2|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[S&H0&D1:3].[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[S&H0&D1:3]|[CH3:1][N:2]=[C:3]=[S:4].[NH2:5][CH2:6][CH2:7][CH2:8][NH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][n:15]1>CC(C)O>[CH3:1][NH:2][C:3](=[S:4])[NH:5][CH2:6][CH2:7][CH2:8][NH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][n:15]1|US20010011096A1_0092
1.2.5|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C:4])=O.[C&H3&D1:3]-[N&H1&+0&D2:2]-[C&H3&D1:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C:4])-[N&H0&+0&D3:2](-[C&H3&D1:3])-[C&H3&D1:1]|[CH3:1][NH:2][CH3:3].[CH3:4][O:5][CH2:6][CH2:7][C:8](=[O:9])[NH:10][C:11]([CH3:12])([CH3:13])[CH2:14][C:15]([CH3:16])=O>Cc1ccc(cc1)S(=O)(=O)O.[O-2].[Pt+2]>[CH3:4][O:5][CH2:6][CH2:7][C:8](=[O:9])[NH:10][C:11]([CH3:12])([CH3:13])[CH2:14][CH:15]([CH3:16])[N:2]([CH3:1])[CH3:3]|US20050277645A1_0287
3.9.65|[C&H3&+0&D1:5]-[C&H2&+0&D2:4]-[#12]-Br.[C:3]-[C&H0&+0&D3:2](=[O&H0&+0&D1:1])-O-C>>[C&H2&+0&D2:5]1-[C&H2&+0&D2:4]-[C&H0&+0&D4:2]-1(-[C:3])-[O&H1&+0&D1:1]|[CH3:1][O:2][CH:3]([CH2:4][C:5](=[O:6])OC)[O:7][CH3:8].[CH3:9][CH2:10][Mg]Br>CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C.CCOCC.C1CCOC1.O>[CH3:1][O:2][CH:3]([CH2:4][C:5]1([CH2:9][CH2:10]1)[OH:6])[O:7][CH3:8]|US20190322686A1_1797
10.1.6|[Br&H0&+0&D1:6]-[Br&H0&+0&D1:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:6]-[C&H1&+0&D3:3](-[C:4])-[C&H1&+0&D3:2](-[Br&H0&+0&D1:5])-[C:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[Cl:10])[S:11](=[O:12])(=[O:13])[N:14]1[CH2:15][CH2:16][CH:17]=[CH:18][CH2:19]1.[Br:20][Br:21]>Cl.CCOCC.CC(=O)O.O[Na]>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[Cl:10])[S:11](=[O:12])(=[O:13])[N:14]1[CH2:15][CH2:16][CH:17]([CH:18]([CH2:19]1)[Br:21])[Br:20]|US04656289A
2.3.2|[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[S&H0&D1:3].[N&H2&+0&D1:2]-[N&H2&D1:1]>>[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N&H2&D1:1])=[S&H0&D1:3]|O.[CH3:1][c:2]1[n:3][cH:4][nH:5][c:6]1[CH2:7][S:8][CH2:9][CH2:10][N:11]=[C:12]=[S:13].[NH2:14][NH2:15]>CCO>[CH3:1][c:2]1[n:3][cH:4][nH:5][c:6]1[CH2:7][S:8][CH2:9][CH2:10][NH:11][C:12](=[S:13])[NH:14][NH2:15]|US09321756B2_0811
10.1.6|[Br&H0&+0&D1:6]-[Br&H0&+0&D1:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[Br&H0&+0&D1:6]-[C&H1&+0&D3:2](-[C:1])-[C&H1&+0&D3:3](-[Br&H0&+0&D1:5])-[C:4]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH:7]=[CH:8][C:9](=[O:10])[C:11]([CH3:12])([CH3:13])[CH3:14].[Br:15][Br:16]>CCOCC>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[CH:7]([Br:16])[CH:8]([Br:15])[C:9](=[O:10])[C:11]([CH3:12])([CH3:13])[CH3:14]|US08629282B2_0282
2.3.1|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[CH3:1][O:2][CH:3]1[CH2:4][CH2:5][CH:6]([c:7]2[cH:8][cH:9][s:10][c:11]21)[NH2:12].[CH3:13][N:14]=[C:15]=[O:16]>CCOCC>[CH3:13][NH:14][C:15](=[O:16])[NH:12][CH:6]1[CH2:5][CH2:4][CH:3]([c:11]2[s:10][cH:9][cH:8][c:7]21)[O:2][CH3:1]|EP2410855B1_0071
3.5.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[#12]-Cl.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][N:2]([CH3:3])[c:4]1[cH:5][c:6]([n:7][c:8]2[s:9][c:10]3[c:11]([n:12][cH:13][n:14]([c:15]3=[O:16])-[c:17]3[cH:18][cH:19][c:20]([cH:21][cH:22]3)[CH3:23])[c:24]21)Cl.[CH3:25][CH:26]([CH3:27])[Mg]Cl>CC1C=C(O[Fe]23(O=1)(O=C(C=C(O3)C)C)O=C(C=C(O2)C)C)C.CN1CCCC1=O.C1CCOC1>[CH3:25][CH:26]([CH3:27])[c:6]1[cH:5][c:4]([c:24]2[c:8]([n:7]1)[s:9][c:10]1[c:11]2[n:12][cH:13][n:14]([c:15]1=[O:16])-[c:17]1[cH:22][cH:21][c:20]([cH:19][cH:18]1)[CH3:23])[N:2]([CH3:1])[CH3:3]|EP2630123B1_0212
1.9.11|[O:7]-[P&H0&+0&D3:6](-[O:5])-[O&H0&+0&D2:4]-C.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[O:7]-[P&H0&+0&D4:6](-[O:5])(=[O&H0&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|C[O:1][P:2]([O:3][CH3:4])[O:5][CH3:6].I[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1>c1ccc(cc1)OP(Oc1ccccc1)Oc1ccccc1>[CH3:6][O:5][P:2](=[O:1])([O:3][CH3:4])[c:7]1[cH:12][cH:11][cH:10][cH:9][cH:8]1|US08119617B2_0584
2.3.1|[C&H3&D1:6]-[N&H2&+0&D1:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][NH2:2].[CH3:3][C:4]([CH3:5])([CH3:6])[c:7]1[cH:8][c:9]([o:10][n:11]1)[N:12]=[C:13]=[O:14]>Cc1ccccc1>[CH3:1][NH:2][C:13](=[O:14])[NH:12][c:9]1[cH:8][c:7]([n:11][o:10]1)[C:4]([CH3:3])([CH3:5])[CH3:6]|EP0003619A2_0058
2.3.1|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[N&H2&+0&D1:2]-[S:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[S:1])=[O&H0&D1:3]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[O:11][C:12]([Cl:13])=[CH:14][Cl:15].[CH3:16][N:17]=[C:18]=[O:19]>CCN(CC)CC.ClCCl>[CH3:16][NH:17][C:18](=[O:19])[NH:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[O:11][C:12]([Cl:13])=[CH:14][Cl:15]|US05668176A
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[O:1]=[C:2](O)[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[S:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH3:16][NH:17][CH3:18]>O=C(Cl)c1ccccc1Sc1ccccc1.c1ccccc1.O=S(Cl)Cl>[CH3:16][N:17]([CH3:18])[C:2](=[O:1])[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[S:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US20190367523A1_0280
2.3.2|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[S&H0&D1:3].[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[S&H0&D1:3]|[CH3:1][N:2]=[C:3]=[S:4].[NH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[F:12]>Cc1ccccc1C>[CH3:1][NH:2][C:3](=[S:4])[NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[F:12]|EP3178810A1_0149
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][O:2][CH:3]([C:4](=[O:5])O)[c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1.[CH3:12][NH:13][CH3:14]>COC(C(=O)Cl)c1ccccn1.c1ccccc1.O=S(Cl)Cl.ClC(Cl)Cl.O[Na].Cl>[CH3:1][O:2][CH:3]([C:4](=[O:5])[N:13]([CH3:12])[CH3:14])[c:6]1[cH:7][cH:8][cH:9][cH:10][n:11]1|US05098919A
2.3.1|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[N&H2&+0&D1:2]-[N:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N:1])=[O&H0&D1:3]|[CH3:1][CH2:2][c:3]1[cH:4][c:5]2[C:6](=[N:7][CH2:8][C:9](=[N:10][c:11]2[s:12]1)[NH:13][NH2:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[Cl:21].[CH3:22][N:23]=[C:24]=[O:25]>O.C1CCOC1>[CH3:1][CH2:2][c:3]1[cH:4][c:5]2[C:6](=[N:7][CH2:8][C:9](=[N:10][c:11]2[s:12]1)[NH:13][NH:14][C:24](=[O:25])[NH:23][CH3:22])[c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[Cl:21]|EP0180754A2_0046
2.5.7|[C:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](=[N&H1&+0&D1:3])-S-C.[C:2]-[N&H2&+0&D1:1]>>[C:6]-[N&H0&+0&D2:5]=[C&H0&+0&D3:4](-[N&H2&+0&D1:3])-[N&H1&+0&D2:1]-[C:2]|[NH2:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([o:7]1)-[c:8]1[cH:9][s:10][c:11]([n:12]1)[N:13]=[C:14]([NH2:15])[NH2:16].[CH3:17][O:18][C:19](=[O:20])[NH:21][C:22](=[NH:23])SC>CCN(CC)CC>[CH3:17][O:18][C:19](=[O:20])[N:21]=[C:22]([NH2:23])[NH:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([o:7]1)-[c:8]1[cH:9][s:10][c:11]([n:12]1)[N:13]=[C:14]([NH2:15])[NH2:16]|US08791260B2_0368
1.8.2|[O&H0&D1:6]=[S&H0&+0&D3:5](-[c:4])-[O&H0&+0&D2:3]-[#3].[c:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&D1:6]=[S&H0&+0&D4:5](-[c:4])(-[C&H2&+0&D2:1]-[c:2])=[O&H0&+0&D1:3]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[n:12][c:13]([c:14]([o:15]1)[CH3:16])[CH2:17]Cl.[CH3:18][N:19]([CH3:20])[CH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[S:28](=[O:29])[O:30][Li]>CN(C)C=O.O=C(O[K])O[K]>[CH3:18][N:19]([CH3:20])[CH2:21][c:22]1[cH:27][cH:26][c:25]([cH:24][cH:23]1)[S:28](=[O:29])(=[O:30])[CH2:17][c:13]1[n:12][c:11]([o:15][c:14]1[CH3:16])-[c:8]1[cH:7][cH:6][c:5]([cH:10][cH:9]1)[C:3](=[O:4])[O:2][CH3:1]|
3.5.3|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[#30]-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C@@H:2]([CH2:3][NH:4][C:5](=[O:6])[c:7]1[cH:8][c:9]([n:10][c:11]([cH:12]1)-[c:13]1[cH:14][n:15][n:16]2[c:17]1[n:18][c:19]([cH:20][cH:21]2)-[c:22]1[cH:23][cH:24][cH:25][s:26]1)Cl)[N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[CH3:32][CH:33]([CH3:34])[Zn]Br>CCC(CC)c1cccc(c1N1C=CN(C1[Pd](Cl)(Cl)[N]1=CC(=CC=C1)Cl)c1c(cccc1C(CC)CC)C(CC)CC)C(CC)CC.Cc1ccccc1>[CH3:31][CH2:30][N:27]([CH2:28][CH3:29])[C@@H:2]([CH3:1])[CH2:3][NH:4][C:5](=[O:6])[c:7]1[cH:8][c:9]([n:10][c:11]([cH:12]1)-[c:13]1[cH:14][n:15][n:16]2[c:17]1[n:18][c:19]([cH:20][cH:21]2)-[c:22]1[cH:23][cH:24][cH:25][s:26]1)[CH:33]([CH3:32])[CH3:34]|
1.7.13|[N:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[N&H1&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-Cl>>[N:6]-[C&H0&+0&D3:5]1-[O&H0&+0&D2:4]-[C&H2&+0&D2:1]-[C:2]-[N&H0&+0&D2:3]=1|[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10]([OH:11])([C:12]([F:13])([F:14])[F:15])[C:16]([F:17])([F:18])[F:19])[NH:20][C:21](=[O:22])[CH2:23]Cl>COCCOC.CC(C)(C)[O-].[K+]>[O:22]=[C:21]1[CH2:23][O:1][C:2](=[N:20]1)[NH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10]([OH:11])([C:16]([F:17])([F:18])[F:19])[C:12]([F:13])([F:14])[F:15]|US10118929B2_0307
2.3.2|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[S&H0&D1:3].[N&H2&+0&D1:2]-[S:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[S:1])=[S&H0&D1:3]|[NH2:1][S:2](=[O:3])(=[O:4])[C:5]([F:6])([F:7])[F:8].[CH3:9][N:10]=[C:11]=[S:12]>CC(C)=O.O[Na].O>[CH3:9][NH:10][C:11](=[S:12])[NH:1][S:2](=[O:3])(=[O:4])[C:5]([F:6])([F:7])[F:8]|EP1117409B1_0054
3.9.65|[C&H3&+0&D1:5]-[C&H2&+0&D2:4]-[#12]-Br.[O&H0&+0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O-C>>[C&H2&+0&D2:5]1-[C&H2&+0&D2:4]-[C&H0&+0&D4:2]-1(-[O&H1&+0&D1:3])-[c:1]|CO[C:1](=[O:2])[c:3]1[cH:4][n:5][c:6]2[C@@H:7]([CH2:8][CH2:9][C@H:10]([CH2:11][n:12]12)[c:13]1[cH:14][cH:15][cH:16][c:17]([c:18]1[F:19])[F:20])[NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28].[CH3:29][CH2:30][Mg]Br>CCOCC.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].[Ti+4]>[CH3:26][C:25]([CH3:27])([CH3:28])[O:24][C:22](=[O:23])[NH:21][C@@H:7]1[CH2:8][CH2:9][C@H:10]([CH2:11][n:12]2[c:6]1[n:5][cH:4][c:3]2[C:1]1([CH2:29][CH2:30]1)[OH:2])[c:13]1[cH:14][cH:15][cH:16][c:17]([c:18]1[F:19])[F:20]|US20200055842A1_2794
1.7.13|[O&H0&+0&D1:6]=[C&H0&+0&D3:5](-[c:4])-[N&H1&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:6]1-[C&H2&+0&D2:1]-[C:2]-[N&H0&+0&D2:3]=[C&H0&+0&D3:5]-1-[c:4]|[CH3:1][c:2]1[cH:3][c:4]([o:5][n:6]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][c:13]1[c:14]([cH:15][c:16]([cH:17][c:18]1[Cl:19])[C:20](=[O:21])[NH:22][CH2:23][CH2:24]Cl)[Cl:25]>CCOCC.ClCCl.C1CCCC2=NCCCN2C1>[CH3:1][c:2]1[cH:3][c:4]([o:5][n:6]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][c:13]1[c:14]([cH:15][c:16]([cH:17][c:18]1[Cl:19])[C:20]1=[N:22][CH2:23][CH2:24][O:21]1)[Cl:25]|EP3004094B1_0277
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[O&H1&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[O&H1&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|Cl.[CH3:1][NH:2][OH:3].[CH3:4][c:5]1[cH:6][cH:7][cH:8][c:9]([c:10]1[CH3:11])[NH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[C:19](=[O:20])O>CN(C)C=O.O=C(n1cncc1)n1cncc1>[CH3:4][c:5]1[cH:6][cH:7][cH:8][c:9]([c:10]1[CH3:11])[NH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[C:19](=[O:20])[N:2]([CH3:1])[OH:3]|US08283366B2_0176
2.1.2|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C&H3&D1:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C&H3&D1:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([c:9]2[cH:10][c:11]3[c:12]([n:13][c:14]([cH:15][c:16]3[NH:17][CH3:18])[C:19](=[O:20])[O:21][CH2:22][CH3:23])[c:24]([c:25]2[o:26]1)[CH2:27][CH2:28][CH3:29])=[O:30].[CH3:31][C:32](=[O:33])O>O.CC(=O)OC(C)=O>[CH3:31][C:32](=[O:33])[N:17]([CH3:18])[c:16]1[cH:15][c:14]([n:13][c:12]2[c:24]([c:25]3[o:26][c:6]([cH:7][c:8]([c:9]3[cH:10][c:11]21)=[O:30])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[CH2:27][CH2:28][CH3:29])[C:19](=[O:20])[O:21][CH2:22][CH3:23]|US20200339559A1_0888
2.4.2|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[OH:1][CH:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[O:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]21.[CH3:16][N:17]=[C:18]=[O:19]>CCN(CC)CC>[CH3:16][NH:17][C:18](=[O:19])[O:1][CH:2]1[c:15]2[cH:14][cH:13][cH:12][cH:11][c:10]2[O:9][c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]21|EP2501704B1_0099
9.7.73|[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[c:3])-O.[N&+:2]=[N&H0&+0&D2:1]-[#11]>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[c:3])-[N&H0&+0&D2:1]=[N&+:2]|[CH3:1][C:2]([CH3:3])(O)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Br:10].[N-:11]=[N+:12]=[N:13][Na]>O=C(O)C(F)(F)F>[CH3:1][C:2]([CH3:3])([N:13]=[N+:12]=[N-:11])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Br:10]|US09856241B2_0577
10.1.6|[Br&H0&+0&D1:6]-[Br&H0&+0&D1:5].[C:4]/[C&H1&+0&D2:3]=[C&H1&+0&D2:2]/[c:1]>>[Br&H0&+0&D1:6]-[C&H1&+0&D3:3](-[C:4])-[C&H1&+0&D3:2](-[Br&H0&+0&D1:5])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])/[CH:6]=[CH:7]/[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[Br:14][Br:15]>ClCCl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([Br:14])[CH:7]([Br:15])[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US10526287B2_0307
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[C&H3&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C&H3&D1:3])=[O&H0&D1:1]|[CH3:1][NH:2][CH:3]1[CH2:4][CH2:5][n:6]2[c:7]([CH2:8]1)[n:9][c:10]([c:11]([c:12]2=[O:13])[OH:14])[C:15](=[O:16])[NH:17][CH2:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25].[CH3:26][C:27](=[O:28])O>CCN=C=NCCCN(C)C.On1nnc2ccccc21.CC(C)N(CC)C(C)C.CC#N.ClCCl.O.Cl>[CH3:26][C:27](=[O:28])[N:2]([CH3:1])[CH:3]1[CH2:4][CH2:5][n:6]2[c:7]([CH2:8]1)[n:9][c:10]([c:11]([c:12]2=[O:13])[OH:14])[C:15](=[O:16])[NH:17][CH2:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25]|US20120165309A1_0241
2.3.2|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[S&H0&D1:3].[N&H2&+0&D1:2]-[N:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[N:1])=[S&H0&D1:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][O:7][CH2:8][C:9](=[O:10])[NH:11][NH2:12].[CH3:13][N:14]=[C:15]=[S:16]>C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][O:7][CH2:8][C:9](=[O:10])[NH:11][NH:12][C:15](=[S:16])[NH:14][CH3:13]|US20200323904A1_0780
10.1.6|[Br&H0&+0&D1:6]-[Br&H0&+0&D1:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[Br&H0&+0&D1:6]-[C&H1&+0&D3:3](-[C:4])-[C&H1&+0&D3:2](-[Br&H0&+0&D1:5])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]=[CH:7][c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[Cl:14])[CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1.[Br:21][Br:22]>ClC(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([Br:21])[CH:7]([Br:22])[c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[Cl:14])[CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1|EP2611771B1_0309
2.3.1|[C&H3&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D2:4]=[O&H0&D1:3].[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[CH3:1][CH2:2][CH:3]([CH3:4])[c:5]1[cH:6][s:7][c:8]([c:9]1[C:10]#[N:11])[NH2:12].[CH3:13][N:14]=[C:15]=[O:16]>COCCOC>[CH3:13][NH:14][C:15](=[O:16])[NH:12][c:8]1[s:7][cH:6][c:5]([c:9]1[C:10]#[N:11])[CH:3]([CH3:4])[CH2:2][CH3:1]|US20110098304A1_0280
3.9.79|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#3]>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][C:6]1=[O:7].[cH:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Li]>O.CCOCC>[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][C:6]1([OH:7])[c:11]1[cH:12][cH:13][cH:8][cH:9][cH:10]1|US20070191364A1_0460
3.7.2|[C&H3&D1:6]-[C&H2&+0&D2:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&D1:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]21)=[O:18].[CH3:19][CH2:20][Mg]Br>CCOCC.[O-]S(=O)(=O)O.[Na+]>[CH3:19][CH2:20][C:11]1([CH2:10][CH2:9][N:8]([c:17]2[cH:16][cH:15][cH:14][cH:13][c:12]21)[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[OH:18]|US20200392073A1_0424
4.1.58|[N&H2&+0&D1:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[C&H1&+0&D2:2](-[C&H1&+0&D2:1]=O)=O>>[n&H0&+0&D2:6]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[n&H0&+0&D2:3]:[c:4]:[c:5]:1|O.[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][c:9]([c:10]([c:11]1[NH:12][CH2:13][CH2:14][CH2:15][N:16]([CH3:17])[CH3:18])[NH2:19])[NH2:20])[CH3:21].O=[CH:22][CH:23]=O>Cc1ccccc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][c:9]2[n:20][cH:22][cH:23][n:19][c:10]2[c:11]1[NH:12][CH2:13][CH2:14][CH2:15][N:16]([CH3:17])[CH3:18])[CH3:21]|US20160184305A1_0447
1.9.11|[O:7]-[P&H0&+0&D3:6](-[O:5])-[O&H0&+0&D2:4]-C.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O:7]-[P&H0&+0&D4:6](-[O:5])(=[O&H0&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)Br)[CH3:15].C[O:16][P:17]([O:18][CH3:19])[O:20][CH3:21]>Cc1ccccc1>[CH3:1][C:2]1([O:3][B:4]([O:5][C:6]1([CH3:7])[CH3:8])[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[P:17](=[O:16])([O:18][CH3:19])[O:20][CH3:21])[CH3:15]|US07868157B2_0167
4.1.58|[N&H2&+0&D1:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[C&H1&+0&D2:2](-[C&H1&+0&D2:1]=O)=O>>[n&H0&+0&D2:6]1:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:[n&H0&+0&D2:3]:[c:4]:[c:5]:1|O.[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[c:7]([c:8]([n:9][c:10]([c:11]1[C:12](=[O:13])[O:14][CH2:15][CH3:16])[CH3:17])[NH2:18])[NH2:19].O=[CH:20][CH:21]=O>O.Cc1ccccc1>[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[c:11]([c:10]([n:9][c:8]2[n:18][cH:20][cH:21][n:19][c:7]21)[CH3:17])[C:12](=[O:13])[O:14][CH2:15][CH3:16]|US20140005188A1_0563
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C@@:2]12[CH2:3][CH2:4][C@H:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@@:14]1([C@H:15]([CH2:16][CH2:17][C@@H:18]21)[C:19](=[O:20])Cl)[CH3:21])=[O:22])[O:23][N+:24]([O-:25])=[O:26].[CH3:27][NH:28][CH3:29]>CCOCC>[CH3:1][C@@:2]12[CH2:3][CH2:4][C@H:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@:14]1([C@H:18]2[CH2:17][CH2:16][C@@H:15]1[C:19](=[O:20])[N:28]([CH3:27])[CH3:29])[CH3:21])=[O:22])[O:23][N+:24]([O-:25])=[O:26]|US20150005277A1_0165
3.7.2|[C&H3&D1:6]-[C&H2&+0&D2:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&D1:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][C:3](=[CH:4][CH2:5][CH2:6][c:7]1[cH:8][cH:9][c:10]2[O:11][CH2:12][O:13][c:14]2[cH:15]1)[CH2:16][CH2:17][CH:18]1[CH2:19][CH2:20][CH2:21][C:22]1=[O:23].[CH3:24][CH2:25][Mg]Br>>[CH3:24][CH2:25][C:22]1([CH2:21][CH2:20][CH2:19][CH:18]1[CH2:17][CH2:16][C:3](=[CH:4][CH2:5][CH2:6][c:7]1[cH:8][cH:9][c:10]2[O:11][CH2:12][O:13][c:14]2[cH:15]1)[CH2:2][CH3:1])[OH:23]|US20120238549A1_0722
4.2.20|[O&H1&+0&D1:7]-[c:6]:[c:5]-[O&H1&+0&D1:4].[c:3]-[C&H0&+0&D4:2](-[c:1])(-Cl)-Cl>>[O&H0&+0&D2:7]1-[c:6]:[c:5]-[O&H0&+0&D2:4]-[C&H0&+0&D4:2]-1(-[c:3])-[c:1]|[O:1]=[C:2]1[NH:3][C:4]([c:5]2[cH:6][cH:7][c:8]([c:9]([c:10]12)[OH:11])[OH:12])=[O:13].Cl[C:14](Cl)([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>>[O:1]=[C:2]1[NH:3][C:4]([c:5]2[cH:6][cH:7][c:8]3[O:12][C:14]([O:11][c:9]3[c:10]12)([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)=[O:13]|US07319101B2_0327
4.2.11|[C&H3&D1:6]-[C&H0&+0&D3:5](=[N&H0&+0&D2:4]-O-C(-C)=O)-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[o&H0&+0&D2:1]:[c:2]:[c:3]:1|CC(=O)O[N:1]=[C:2]([CH3:3])[c:4]1[cH:5][c:6]([c:7]([cH:8][c:9]1[OH:10])[Br:11])[CH3:12]>CCCCCC.CCOC(C)=O.ClCCl>[CH3:12][c:6]1[cH:5][c:4]2[c:2]([n:1][o:10][c:9]2[cH:8][c:7]1[Br:11])[CH3:3]|US20200010462A1_0997
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][NH:2][CH3:3].[O:4]=[C:5](Cl)[c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[O:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>ClCCl>[CH3:1][N:2]([CH3:3])[C:5](=[O:4])[c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[O:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|EP3660016A1_0596
3.9.79|[O&H0&+0&D1:7]=[C&H0&+0&D3:6](-[c:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#3]>>[O&H1&+0&D1:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][c:7]([c:8]2[C:9]([c:10]2[c:11]([cH:12][cH:13][cH:14][c:15]12)[OH:16])=[O:17])[OH:18].[cH:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Li]>C1CCOC1>[O:17]=[C:9]1[c:8]2[c:7]([cH:6][cH:5][cH:4][c:3]2[C:2]([c:15]2[cH:14][cH:13][cH:12][c:11]([c:10]12)[OH:16])([OH:1])[c:22]1[cH:21][cH:20][cH:19][cH:24][cH:23]1)[OH:18]|US06140503A
2.3.9|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][NH:2][CH3:3].[O:4]=[C:5](Cl)[N:6]1[CH2:7][CH2:8][NH:9][C:10]1=[O:11]>Cl.Cl[Na].C1CCOC1>[CH3:1][N:2]([CH3:3])[C:5](=[O:4])[N:6]1[CH2:7][CH2:8][NH:9][C:10]1=[O:11]|US20100104659A1_1224
1.2.14|[N&H4&+&D0:6].[C:5]-[C&H1&+0&D3:4]1-[O&H0&+0&D2:3]-[C&H1&+0&D3:2]-1-[c:1]>>[N&H2&+0&D1:6]-[C@@&H1&+0&D3:2](-[c:1])-[C@&H1&+0&D3:4](-[C:5])-[O&H1&+0&D1:3]|[NH4+:1].[CH3:2][C:3]1([CH2:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[CH:11]2[O:12][CH:13]21)[C:14]#[N:15])[CH3:16].[OH-]>CCO.CCOC(C)=O>[CH3:2][C:3]1([CH2:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[C@H:11]([C@@H:13]1[OH:12])[NH2:1])[C:14]#[N:15])[CH3:16]|US20070299130A1_0245
3.7.2|[C&H1&D1:6]#[C&H0&+0&D2:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H1&D1:6]#[C&H0&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][c:7]2[C:8]([O:9][CH2:10][c:11]2[cH:12]1)=[O:13])[C:14](=[O:15])[CH2:16][C:17]1([CH2:18][CH2:19]1)[c:20]1[cH:21][c:22]([cH:23][cH:24][c:25]1[F:26])[C:27]([F:28])([F:29])[F:30].[CH:31]#[C:32][Mg]Br>C1CCOC1.[NH4+].O.[Cl-]>[CH:31]#[C:32][C:14]([OH:15])([CH2:16][C:17]1([CH2:18][CH2:19]1)[c:20]1[cH:21][c:22]([cH:23][cH:24][c:25]1[F:26])[C:27]([F:28])([F:29])[F:30])[C:2](=[O:1])[NH:3][c:4]1[cH:5][cH:6][c:7]2[C:8]([O:9][CH2:10][c:11]2[cH:12]1)=[O:13]|US20190389899A1_0328
2.1.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[O&H1&D1:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[O&H1&D1:3])-[c:1]|[CH3:1][C:2](=[O:3])Cl.[OH:4][NH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1>[Na+].CCOCC.[O-]C(=O)O>[CH3:1][C:2](=[O:3])[N:5]([OH:4])[c:6]1[cH:11][cH:10][cH:9][cH:8][cH:7]1|US10676424B2_0427
3.7.2|[C&H1&D1:6]#[C&H0&+0&D2:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H1&D1:6]#[C&H0&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH:1]#[C:2][Mg]Br.[O:3]=[C:4]([O:5][CH:6]1[CH2:7][N:8]2[CH2:9][CH2:10][CH:11]1[CH2:12][CH2:13]2)[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>[NH4+].O.[Cl-].C#C.CCBr.C1CCOC1.[Mg]>[CH:1]#[C:2][C:14]([OH:15])([C:4](=[O:3])[O:5][CH:6]1[CH2:7][N:8]2[CH2:13][CH2:12][CH:11]1[CH2:10][CH2:9]2)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20140235533A1_0777
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[C&H3&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C&H3&D1:3])=[O&H0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][CH:19]([OH:20])[CH2:21][NH:22][CH3:23].[CH3:24][C:25](=[O:26])Cl>CCN(CC)CC.ClC(Cl)Cl>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][CH2:18][CH:19]([OH:20])[CH2:21][N:22]([CH3:23])[C:25]([CH3:24])=[O:26]|EP3060563B1_0322
2.3.1|[C:7]-[N&H2&+&D2:6]-[C:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3]1([CH2:4][C@@H:5]([NH2+:6][CH2:7]1)[C:8](=[O:9])[NH:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)-[n:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1=[O:23])[O:24][CH3:25].[O:26]=[C:27]=[N:28][c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[Cl:35].[Cl-]>CCN(CC)CC>[CH3:1][O:2][C:3]1([CH2:4][C@@H:5]([N:6]([CH2:7]1)[C:27](=[O:26])[NH:28][c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[Cl:35])[C:8](=[O:9])[NH:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)-[n:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1=[O:23])[O:24][CH3:25]|US20170137417A1_0212
3.9.79|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#3]>>[C:7]-[C&H0&+0&D4:6](-[O&H1&+0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:5][CH2:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[C:13]([CH2:14]1)=[O:15].[cH:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Li]>[NH4+].O.[Cl-].CCOCC>[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:5][CH2:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[C:13]([CH2:14]1)([OH:15])[c:19]1[cH:20][cH:21][cH:16][cH:17][cH:18]1|US20200102300A1_0060
3.7.2|[C&H2&D1:6]=[C&H1&+0&D2:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H2&D1:6]=[C&H1&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[O&H1&+0&D1:2])-[c:1]|[CH2:1]=[CH:2][Mg]Br.[O:3]=[C:4]([c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11])[CH:12]1[CH2:13][CH2:14]1>C1CCOC1>[CH2:1]=[CH:2][C:4]([OH:3])([c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11])[CH:12]1[CH2:13][CH2:14]1|US20200369634A1_0208
2.1.1|[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-Cl.[C&H3&D1:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C&H3&D1:3])-[c:1]|[CH:1]#[C:2][CH2:3][c:4]1[c:5]([n:6][c:7]2[c:8]([cH:9][cH:10][cH:11][n:12]12)[O:13][CH2:14][c:15]1[c:16]([cH:17][cH:18][cH:19][c:20]1[NH:21][CH3:22])[CH3:23])[CH3:24].[CH3:25][C:26](=[O:27])Cl>CCN(CC)CC.ClCCl>[CH:1]#[C:2][CH2:3][c:4]1[c:5]([n:6][c:7]2[c:8]([cH:9][cH:10][cH:11][n:12]12)[O:13][CH2:14][c:15]1[c:16]([cH:17][cH:18][cH:19][c:20]1[N:21]([CH3:22])[C:26]([CH3:25])=[O:27])[CH3:23])[CH3:24]|US20200283437A1_0289
2.1.24|[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[c:2].[N&H0&-&D1:1]=[N&+]=[N&-]>>[C:6]-[C&H2&+0&D2:5]-[N&H1&+0&D2:1]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[c:2]|[Na+].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[C:7]([CH2:8][CH2:9][c:10]2[cH:11]1)=[O:12].[N-:13]=[N+]=[N-]>[Na+].[Na+].CS(=O)(=O)O.[O-]C(=O)O.ClCCl.[OH-]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[C:7]([NH:13][CH2:8][CH2:9][c:10]2[cH:11]1)=[O:12]|US20200010477A1_0472
3.7.2|[C&H2&D1:6]=[C&H1&+0&D2:5]-[#12]-Br.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H2&D1:6]=[C&H1&+0&D2:5]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH2:1]=[CH:2][Mg]Br.[CH3:3][CH:4]([CH3:5])[CH2:6][CH2:7][C:8](=[O:9])[C@H:10]([CH2:11][CH:12]([CH3:13])[CH3:14])[NH:15][S:16](=[O:17])(=[O:18])[CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>C1CCOC1>[CH2:1]=[CH:2][C:8]([OH:9])([CH2:7][CH2:6][CH:4]([CH3:3])[CH3:5])[C@H:10]([CH2:11][CH:12]([CH3:13])[CH3:14])[NH:15][S:16](=[O:17])(=[O:18])[CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US20190169221A1_0500
2.3.1|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[N:3]-[N&H1&+0&D2:2]-[c:1]>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[N:3])-[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[N:9]=[N:10][NH:11][c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[C:18]#[N:19])[C:20]([F:21])([F:22])[F:23])[C:24]([F:25])([F:26])[F:27].[CH3:28][CH2:29][CH2:30][N:31]=[C:32]=[O:33]>CCOCC>[CH3:28][CH2:29][CH2:30][NH:31][C:32](=[O:33])[N:11]([N:10]=[N:9][c:8]1[cH:7][c:6]([cH:5][cH:4][c:3]1[C:2]#[N:1])[C:24]([F:25])([F:26])[F:27])[c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[C:18]#[N:19])[C:20]([F:21])([F:22])[F:23]|US09096545B2_0533
10.3.1|[C:6]-[O&H1&+0&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[O&H1&D1:1])-O>>[C:6]-[O&H0&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[O&H1&D1:1]|[O:1]=[S:2](=[O:3])(O)[OH:4].[OH:5][CH2:6][C@@H:7]1[CH2:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[CH2:15][NH:16]1>O>[O:1]=[S:2](=[O:3])([OH:4])[O:5][CH2:6][C@@H:7]1[CH2:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[CH2:15][NH:16]1|US09994574B2_0155
2.3.1|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[NH:5][c:6]1[n:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[nH:14]1.[O:15]=[C:16]=[N:17][C:18](=[O:19])[C:20]([Cl:21])=[C:22]([Cl:23])[Cl:24]>C1CN2CCN1CC2.C1CCOC1>[CH3:1][O:2][C:3](=[O:4])[NH:5][c:6]1[n:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[n:14]1[C:16](=[O:15])[NH:17][C:18](=[O:19])[C:20]([Cl:21])=[C:22]([Cl:23])[Cl:24]|US20160168101A1_0242
2.3.1|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[C:3]-[N&H1&+0&D2:2]-[N:1]>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[N:1]|[F:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[CH:8]([CH2:9][CH2:10][CH2:11][N:12]1[CH2:13][CH2:14][NH:15][NH:16][CH2:17][CH2:18]1)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25].[CH3:26][CH2:27][N:28]=[C:29]=[O:30].Cl.Cl>CC(C)N(CC)C(C)C.ClCCl>[CH3:26][CH2:27][NH:28][C:29](=[O:30])[N:16]1[CH2:17][CH2:18][N:12]([CH2:13][CH2:14][NH:15]1)[CH2:11][CH2:10][CH2:9][CH:8]([c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25])[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[F:1]|US09815851B2_0750
2.3.1|[C:7]-[N&H1&+0&D2:6]-[c:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[S:1]>>[C:7]-[N&H0&+0&D3:6](-[c:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[S:1]|[O:1]=[C:2]=[N:3][S:4](=[O:5])(=[O:6])[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.[CH3:13][CH2:14][NH:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Br:22]>CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O.CCCC[Sn+2]CCCC.CCN(CC)CC.c1ccccc1>[CH3:13][CH2:14][N:15]([C:2](=[O:1])[NH:3][S:4](=[O:5])(=[O:6])[c:7]1[cH:12][cH:11][cH:10][cH:9][cH:8]1)[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Br:22]|EP0885890A1_0149
2.3.2|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[S&H0&D1:4].[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[S&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[NH2:1][C:2](=[O:3])[c:4]1[cH:5][n:6][n:7]2[C:8](=[CH:9][CH2:10][NH:11][c:12]12)[c:13]1[cH:14][cH:15][cH:16][c:17]([cH:18]1)[C:19]([F:20])([F:21])[F:22].[O:23]=[C:24]([N:25]=[C:26]=[S:27])[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>CC(C)=O>[NH2:1][C:2](=[O:3])[c:4]1[cH:5][n:6][n:7]2[C:8](=[CH:9][CH2:10][N:11]([c:12]12)[C:26](=[S:27])[NH:25][C:24](=[O:23])[c:28]1[cH:33][cH:32][cH:31][cH:30][cH:29]1)[c:13]1[cH:14][cH:15][cH:16][c:17]([cH:18]1)[C:19]([F:20])([F:21])[F:22]|EP2010535B1_0189
2.3.1|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[O:1]=[C:2]([N:3]=[C:4]=[O:5])[c:6]1[c:7]([cH:8][cH:9][cH:10][c:11]1[Cl:12])[Cl:13].[N:14]#[C:15][CH2:16][NH:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[Cl:24]>c1ccccc1>[N:14]#[C:15][CH2:16][N:17]([C:4](=[O:5])[NH:3][C:2](=[O:1])[c:6]1[c:7]([cH:8][cH:9][cH:10][c:11]1[Cl:12])[Cl:13])[c:18]1[cH:23][cH:22][c:21]([cH:20][cH:19]1)[Cl:24]|US20190284136A1_0593
1.9.20|[C:6]-[O&H1&+0&D1:5].[O&H0&D1:4]=[P&H0&+0&D4:3](-[O&H1&D1:2])(-[O&H1&D1:1])-O>>[C:6]-[O&H0&+0&D2:5]-[P&H0&+0&D4:3](=[O&H0&D1:4])(-[O&H1&D1:2])-[O&H1&D1:1]|[O:1]=[P:2]([OH:3])([OH:4])O.[OH:5][CH2:6][CH:7]([OH:8])[CH2:9][OH:10]>>[O:1]=[P:2]([OH:3])([OH:4])[O:5][CH2:6][CH:7]([OH:8])[CH2:9][OH:10]|US20070281909A1_0869
2.3.2|[C:7]-[N&H1&+0&D2:6]-[N:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:7]-[N&H0&+0&D3:6](-[N:5])-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[F:1][CH:2]([F:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11]1=[N:12][NH:13][CH2:14][CH:15]1[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[S:22]=[C:23]=[N:24][c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[Cl:31]>CCOCC>[F:1][CH:2]([F:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11]1=[N:12][N:13]([CH2:14][CH:15]1[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[C:23](=[S:22])[NH:24][c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[Cl:31]|EP0414112A2_0051
1.2.16|[C&H3&D1:7]-[C&H1&+0&D2:6]=[C&H1&+0&D2:5]-[C:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:7]-[C&H1&+0&D3:6](-[C&H2&+0&D2:5]-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]=[CH:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([c:10]2[CH2:11][CH2:12][CH2:13][CH2:14][c:15]12)[O:16][CH3:17].[CH2:18]1[CH2:19][CH2:20][NH:21][CH2:22]1>CCO>[CH3:17][O:16][c:9]1[cH:8][cH:7][c:6]([c:15]2[CH2:14][CH2:13][CH2:12][CH2:11][c:10]12)[C:4](=[O:5])[CH2:3][CH:2]([CH3:1])[N:21]1[CH2:20][CH2:19][CH2:18][CH2:22]1|US08288548B2_0040
4.1.45|[C:7]-[C&H1&+0&D2:6]=O.[C:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H0&+&D3:1](-[O&-])=O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D3:4](-[C:5]):[c:3]:[c:2]:[n&H0&+0&D2:1]:1|[CH3:1][CH2:2][CH2:3][CH:4]=O.[CH3:5][O:6][C:7](=[O:8])/[CH:9]=[CH:10]/[c:11]1[cH:12][cH:13][c:14]([c:15]([cH:16]1)[N+:17]([O-])=O)[NH:18][CH2:19][CH2:20][NH2:21]>CO.CC(=O)O.[Zn]>[CH3:5][O:6][C:7](=[O:8])/[CH:9]=[CH:10]/[c:11]1[cH:12][cH:13][c:14]2[c:15]([cH:16]1)[n:17][c:4]([n:18]2[CH2:19][CH2:20][NH2:21])[CH2:3][CH2:2][CH3:1]|US20200354350A1_1126
1.8.15|[F&H0&D1:6]-[C&H0&+0&D4:5](-[F&H0&D1:4])(-[F&H0&D1:3])-I.[S&H1&+0&D1:2]-[c:1]>>[F&H0&D1:6]-[C&H0&+0&D4:5](-[F&H0&D1:4])(-[F&H0&D1:3])-[S&H0&+0&D2:2]-[c:1]|[F:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[n:9][c:10]([n:11][cH:12][c:13]1-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[F:20])[SH:21].[F:22][C:23]([F:24])([F:25])I>C1CCOC1.N>[F:20][c:17]1[cH:16][cH:15][c:14]([cH:19][cH:18]1)-[c:13]1[cH:12][n:11][c:10]([n:9][c:8]1-[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[F:1])[S:21][C:23]([F:22])([F:24])[F:25]|US20090176786A1_0747
2.3.1|[C:7]-[N&H1&+0&D2:6]-[C:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[n:4][n:5][c:6]([s:7]1)[N:8]=[C:9]=[O:10].[CH3:11][CH2:12][NH:13][CH2:14][CH2:15][CH:16]=[O:17]>c1ccccc1>[CH3:11][CH2:12][N:13]([CH2:14][CH2:15][CH:16]=[O:17])[C:9](=[O:10])[NH:8][c:6]1[n:5][n:4][c:3]([s:7]1)[O:2][CH3:1]|US20070219197A1_0425
2.3.1|[C:7]-[N&H1&+0&D2:6]-[N:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:7]-[N&H0&+0&D3:6](-[N:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[O:1]=[C:2]=[N:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][CH:11]([F:12])[F:13].[Cl:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[C:21]1[CH2:22][CH:23]([NH:24][N:25]=1)[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[Cl:32]>Cc1ccccc1>[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[O:10][CH:11]([F:12])[F:13])[N:24]1[N:25]=[C:21]([CH2:22][CH:23]1[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[Cl:32])[c:18]1[cH:19][cH:20][c:15]([cH:16][cH:17]1)[Cl:14]|US20100137394A1_0126
2.3.1|[O&H0&D1:7]=[C&H0&+0&D2:6]=[N&H0&+0&D2:5]-[c:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[O&H0&D1:7]=[C&H0&+0&D3:6](-[N&H1&+0&D2:5]-[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[C:2]=[N:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[cH:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[S:16][c:17]1[cH:18][c:19]([n:20][nH:21]1)-[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>Cc1ccccc1>[O:1]=[C:2]([NH:3][c:4]1[cH:9][cH:8][cH:7][cH:6][cH:5]1)[n:21]1[n:20][c:19]([cH:18][c:17]1[S:16][c:13]1[cH:14][cH:15][cH:10][cH:11][cH:12]1)-[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|US20130338106A1_0177
2.3.1|[C:7]-[N&H1&+0&D2:6]-[c:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:7]-[N&H0&+0&D3:6](-[c:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([cH:7][c:8]1[O:9][CH3:10])[CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH:16]([CH2:17][CH:18]21)[NH:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[O:26]=[C:27]=[N:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1>>[CH3:10][O:9][c:8]1[cH:7][c:6]2[CH2:11][CH2:12][N:13]3[CH2:14][CH2:15][CH:16]([CH2:17][CH:18]3[c:5]2[cH:4][c:3]1[O:2][CH3:1])[N:19]([C:27](=[O:26])[NH:28][c:29]1[cH:34][cH:33][cH:32][cH:31][cH:30]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US20190284136A1_0111
2.6.9|[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C&H3&D1:3])-O.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C&H3&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2]1[CH2:3][S:4]([C@@H:5]2[CH:6]([C:7]([N:8]2[C:9]=1[C:10](=[O:11])[OH:12])=[O:13])[NH:14][C:15](=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:23].[CH3:24][C:25]([CH3:26])([CH3:27])O>C(=NC1CCCCC1)=NC1CCCCC1.ClCCl.Cl[Cu]>[CH3:1][C:2]1[CH2:3][S:4]([C@@H:5]2[CH:6]([C:7]([N:8]2[C:9]=1[C:10](=[O:11])[O:12][C:25]([CH3:24])([CH3:26])[CH3:27])=[O:13])[NH:14][C:15](=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:23]|US06919338B2_1369
1.2.16|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[C:4].[C&H3&D1:3]-[N&H1&+0&D2:2]-[C&H3&D1:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[C:4])-[N&H0&+0&D3:2](-[C&H3&D1:3])-[C&H3&D1:1]|[CH2:1]=[CH:2][C:3](=[O:4])[O:5][CH2:6][CH3:7].[CH3:8][NH:9][CH3:10]>COc1ccc(cc1)O.c1cccc2Nc3ccccc3Sc12>[CH3:7][CH2:6][O:5][C:3](=[O:4])[CH2:2][CH2:1][N:9]([CH3:8])[CH3:10]|US10787444B2_0368
2.3.1|[C:7]-[N&H1&+0&D2:6]-[C:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[S:1]>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[S:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:9][c:10]1[cH:11][cH:12][n:13][c:14]2[cH:15][c:16]([cH:17][cH:18][c:19]21)[C:20]([F:21])([F:22])[F:23])[N:24]1[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]1.[CH3:30][c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[S:37](=[O:38])(=[O:39])[N:40]=[C:41]=[O:42]>ClCCl>[CH3:30][c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[S:37](=[O:38])(=[O:39])[NH:40][C:41](=[O:42])[N:27]1[CH2:28][CH2:29][N:24]([CH2:25][CH2:26]1)[C:2](=[O:1])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:9][c:10]1[cH:11][cH:12][n:13][c:14]2[cH:15][c:16]([cH:17][cH:18][c:19]12)[C:20]([F:21])([F:22])[F:23]|US20090042852A1_0881
2.3.2|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[S&H0&D1:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[S&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5]1=[CH:6][CH2:7][NH:8][CH2:9][CH2:10]1.[CH3:11][CH2:12][N:13]=[C:14]=[S:15]>C1CCOC1>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5]1=[CH:6][CH2:7][N:8]([CH2:9][CH2:10]1)[C:14](=[S:15])[NH:13][CH2:12][CH3:11]|US20190010167A1_0478
2.3.1|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[n:6]1[nH:7][c:8]([n:9]([c:10]1=[O:11])-[c:12]1[cH:13][c:14]([cH:15][c:16]([cH:17]1)[Cl:18])[Cl:19])=[O:20].[CH3:21][CH:22]([CH3:23])[N:24]=[C:25]=[O:26]>CCN(CC)CC.CN(C)C=O.O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[n:6]1[c:10]([n:9]([c:8]([n:7]1[C:25](=[O:26])[NH:24][CH:22]([CH3:21])[CH3:23])=[O:20])-[c:12]1[cH:13][c:14]([cH:15][c:16]([cH:17]1)[Cl:18])[Cl:19])=[O:11]|US20130172384A1_0407
2.3.1|[C:7]-[N&H1&+0&D2:6]-[C:5].[C:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:2]=[O&H0&D1:1]>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:2](=[O&H0&D1:1])-[N&H1&+0&D2:3]-[C:4]|Cl.Cl.[CH3:1][CH2:2][N:3]=[C:4]=[O:5].[CH3:6][N:7]1[CH2:8][CH:9]2[CH2:10][CH2:11][CH:12]([CH2:13]1)[NH:14]2>CN1CC2CCC(C1)N2C(=O)OCC>[CH3:6][N:7]1[CH2:8][CH:9]2[CH2:10][CH2:11][CH:12]([CH2:13]1)[N:14]2[C:4](=[O:5])[NH:3][CH2:2][CH3:1]|US20200255403A1_0364
2.3.1|[O&H0&D1:7]=[C&H0&+0&D2:6]=[N&H0&+0&D2:5]-[c:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[O&H0&D1:7]=[C&H0&+0&D3:6](-[N&H1&+0&D2:5]-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[n:3][cH:4][cH:5][nH:6]1.[O:7]=[C:8]=[N:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>O.Cc1ccccc1>[CH3:1][c:2]1[n:3][cH:4][cH:5][n:6]1[C:8](=[O:7])[NH:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|US20040053908A1_1612
2.3.2|[C:7]-[N&H1&+0&D2:6]-[C:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[OH:1][CH2:2][C@@H:3]1[CH2:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[CH2:11][NH:12]1.[S:13]=[C:14]=[N:15][c:16]1[cH:17][n:18][cH:19][cH:20][cH:21]1>CCO>[OH:1][CH2:2][C@@H:3]1[CH2:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[CH2:11][N:12]1[C:14](=[S:13])[NH:15][c:16]1[cH:21][cH:20][cH:19][n:18][cH:17]1|US07745630B2_0441
1.2.17|[C&H2&+0&D1:6]=[C&H1&+0&D2:5]-[S:4].[C&H3&D1:3]-[N&H1&+0&D2:2]-[C&H3&D1:1]>>[C&H2&+0&D2:6](-[C&H2&+0&D2:5]-[S:4])-[N&H0&+0&D3:2](-[C&H3&D1:3])-[C&H3&D1:1]|[CH2:1]=[CH:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N:12]1[CH2:13][CH2:14][C:15](=[N:16]1)[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23].[CH3:24][NH:25][CH3:26]>CCO.CC(=O)O>[CH3:24][N:25]([CH3:26])[CH2:1][CH2:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N:12]1[CH2:13][CH2:14][C:15](=[N:16]1)[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23]|US20040248905A1_0098
2.3.2|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[S&H0&D1:4].[C:3]-[N&H1&+0&D2:2]-[N:1]>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[S&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[N:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][O:6][C:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[C:15]1([CH2:16][C:17](=[C:18]([S:19]1)[N:20]=[C:21]=[S:22])[F:23])[Cl:24].[CH2:25]1[CH2:26][CH2:27][NH:28][NH:29][CH2:30]1>Cc1ccccc1>[CH3:1][O:2][C:3](=[O:4])[CH2:5][O:6][C:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[C:15]1([CH2:16][C:17](=[C:18]([S:19]1)[NH:20][C:21](=[S:22])[N:29]1[CH2:30][CH2:25][CH2:26][CH2:27][NH:28]1)[F:23])[Cl:24]|EP1879886B1_0300
2.3.2|[C:7]-[N&H1&+0&D2:6]-[c:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C:7]-[N&H0&+0&D3:6](-[c:5])-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][C:2](=[O:3])[NH:4][NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[NH:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[S:20]=[C:21]=[N:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>O.CCO>[CH3:1][C:2](=[O:3])[NH:4][NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[N:12]([CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[C:21](=[S:20])[NH:22][c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1|US09834558B2_0785
2.3.1|[O&H0&D1:7]=[C&H0&+0&D2:6]=[N&H0&+0&D2:5]-[c:4].[c:3]-[N&H1&+0&D2:2]-[c:1]>>[O&H0&D1:7]=[C&H0&+0&D3:6](-[N&H1&+0&D2:5]-[c:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[O:1]=[C:2]=[N:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[cH:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[NH:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>Cc1ccccc1.NC(N)=O.[O-]P([O-])([O-])=O>[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[N:16]([c:13]1[cH:12][cH:11][cH:10][cH:15][cH:14]1)[c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|US08153663B2_0274
2.3.1|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[c:3]-[N&H1&+0&D2:2]-[c:1]>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[c:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][N:5]=[C:6]=[O:7].[cH:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[NH:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CCCCOP(=O)(O)OCCCC.Cc1ccccc1C>[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:7])[N:14]([c:11]1[cH:10][cH:9][cH:8][cH:13][cH:12]1)[c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|US08153663B2_0355
2.5.5|[C&H3&D1:6]-[N&H1&+0&D2:5]-[O&H1&D1:4].[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[O&H1&D1:4])-[C&H0&+0&D3:2](-[C:3])=[N&H1&+0&D1:1]|Cl.[CH3:1][NH:2][OH:3].[N:4]#[C:5][CH:6]1[CH2:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[N:14]1[C:15](=[O:16])[O:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>CCO.CCN(CC)CC>[CH3:1][N:2]([OH:3])[C:5](=[NH:4])[CH:6]1[CH2:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[N:14]1[C:15](=[O:16])[O:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|US20200339526A1_0465
2.3.2|[N&H2&+0&D1:6]-[N&H2&D1:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[N&H1&+0&D2:6](-[N&H2&D1:5])-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][NH2:2].[S:3]=[C:4]=[N:5][c:6]1[cH:7][cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[cH:15]1>CCOCC>[NH2:2][NH:1][C:4](=[S:3])[NH:5][c:6]1[cH:7][cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[cH:15]1|US20200140381A1_0287
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[Cl&H0&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[Cl&H0&D1:3])=[O&H0&D1:1]|[CH3:1][S:2][c:3]1[n:4][n:5][c:6]([s:7]1)[NH:8][CH3:9].[O:10]=[C:11]([Cl:12])Cl>c1ccccc1>[CH3:1][S:2][c:3]1[n:4][n:5][c:6]([s:7]1)[N:8]([CH3:9])[C:11](=[O:10])[Cl:12]|EP0247482A2_0048
4.1.76|[N&H2&+0&D1:6]-[N&H1&+0&D2:5]-[c:4]:[n&H0&+0&D2:3]:[n:2].[C&H1&+0&D2:1](=O)-O>>[n&H0&+0&D2:6]1:[c&H1&+0&D2:1]:[n&H0&+0&D3:3](:[n:2]):[c:4]:[n&H0&+0&D2:5]:1|[CH3:1][c:2]1[cH:3][c:4]([n:5][n:6][c:7]1[NH:8][NH2:9])[N:10]1[CH2:11][CH2:12][O:13][CH2:14][CH2:15]1.O=[CH:16]O>>[CH3:1][c:2]1[cH:3][c:4]([n:5][n:6]2[cH:16][n:9][n:8][c:7]12)[N:10]1[CH2:11][CH2:12][O:13][CH2:14][CH2:15]1|US20060154930A1_0434
4.2.40|[O&H1&+0&D1:6]-[c:5]:[c:4]-[O&H1&+0&D1:3].[C&H2&+0&D2:2](-[C&H2&+0&D2:1]-Br)-Br>>[O&H0&+0&D2:6]1-[C&H2&+0&D2:1]-[C&H2&+0&D2:2]-[O&H0&+0&D2:3]-[c:4]:[c:5]-1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([c:8]1[OH:9])[OH:10])[C:11](=[O:12])[OH:13].Br[CH2:14][CH2:15]Br>O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[O:10][CH2:15][CH2:14][O:9][c:8]12)[C:11](=[O:12])[OH:13]|EP3696174A1_0306
2.2.3|[C:6]-[N&H2&+0&D1:5].[N&H2&D1:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:6]-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](-[N&H2&D1:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[NH2:1][CH2:2][C@@H:3]1[CH2:4][C@@H:5]([CH2:6][N:7]1[C:8](=[O:9])[O:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[N+:18]([O-:19])=[O:20])[SH:21].[NH2:22][S:23](=[O:24])(=[O:25])Cl>CCN(CC)CC.C[Si](C)(C)Cl.ClCCl.Cl>[NH2:22][S:23](=[O:24])(=[O:25])[NH:1][CH2:2][C@@H:3]1[CH2:4][C@@H:5]([CH2:6][N:7]1[C:8](=[O:9])[O:10][CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[N+:18]([O-:19])=[O:20])[SH:21]|US20200291024A1_0851
2.7.2|[C:6]-[O&H1&+0&D1:5].[N&H2&D1:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:6]-[O&H0&+0&D2:5]-[S&H0&+0&D4:3](-[N&H2&D1:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH2:11][CH2:12][OH:13].[NH2:14][S:15](=[O:16])(=[O:17])Cl>CN(C)C=O.[NaH]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[CH2:11][CH2:12][O:13][S:15]([NH2:14])(=[O:16])=[O:17]|EP2049491B1_0370
2.7.2|[C&H3&D1:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-Cl.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[CH2:11][CH2:12][C@@H:13]1[C@@H:14]2[CH2:15][CH2:16][C@:17]2([C@H:18]1[CH2:19][CH2:20][C@@H:21]2[OH:22])[CH3:23].[CH3:24][S:25](=[O:26])(=[O:27])Cl>O.c1ccncc1>[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[CH2:11][CH2:12][C@@H:13]1[C@@H:14]2[CH2:15][CH2:16][C@:17]2([C@H:18]1[CH2:19][CH2:20][C@@H:21]2[O:22][S:25]([CH3:24])(=[O:26])=[O:27])[CH3:23]|EP3484894B1_1238
2.2.3|[C&H3&D1:6]-[N&H2&+0&D1:5].[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][S:2](=[O:3])(=[O:4])[CH2:5][CH2:6][S:7](=[O:8])(=[O:9])Cl.[CH3:10][NH2:11]>O.ClC(Cl)Cl>[CH3:1][S:2](=[O:3])(=[O:4])[CH2:5][CH2:6][S:7](=[O:8])(=[O:9])[NH:11][CH3:10]|US20190382349A1_0390
4.1.13|[N&H2&+0&D1:6]-[N&H2&+0&D1:5].[n:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-F>>[n&H0&+0&D2:6]1:[n&H1&+0&D2:5]:[c&H0&+0&D3:3](:[n:4]):[c:2]:[c&H1&+0&D2:1]:1|[NH2:1][NH2:2].O=[CH:3][c:4]1[c:5]([cH:6][cH:7][n:8][c:9]1F)[I:10]>C1CCOC1>[I:10][c:5]1[cH:6][cH:7][n:8][c:9]2[nH:2][n:1][cH:3][c:4]12|US10285983B2_0743
1.2.14|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[C&H2&+0&D2:3]1-[C:2]-[O&H0&+0&D2:1]-1>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H2&+0&D2:3]-[C:2]-[O&H1&+0&D1:1]|[CH3:1][NH:2][CH3:3].[cH:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[CH:17]1[CH2:18][O:19]1>CCO>[CH3:1][N:2]([CH3:3])[CH2:18][CH:17]([OH:19])[CH:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:7]1[cH:6][cH:5][cH:4][cH:9][cH:8]1|US20190358233A1_0526
4.1.13|[N&H2&+0&D1:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-F>>[n&H0&+0&D2:6]1:[n&H1&+0&D2:5]:[c&H0&+0&D3:3](:[c:4]):[c:2]:[c&H1&+0&D2:1]:1|O.[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[CH:9]=O)F.[NH2:10][NH2:11]>ClCCl>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[nH:11][n:10][cH:9][c:7]2[cH:8]1|US20200331911A1_0629
2.2.3|[C&H3&D1:6]-[N&H2&+0&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][C:2](=[O:3])[N:4]1[CH2:5][CH2:6][c:7]2[cH:8][cH:9][c:10]([cH:11][c:12]2[CH2:13]1)[S:14](=[O:15])(=[O:16])Cl.[CH3:17][NH2:18]>>[CH3:1][C:2](=[O:3])[N:4]1[CH2:5][CH2:6][c:7]2[cH:8][cH:9][c:10]([cH:11][c:12]2[CH2:13]1)[S:14](=[O:15])(=[O:16])[NH:18][CH3:17]|EP3670499A1_0234
5.2.1|[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C&H3&D1:3])-Br.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C&H3&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2]#[C:3][CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:12](=[O:13])(=[O:14])[NH:15][C@@H:16]([C:17](=[O:18])[OH:19])[C:20]([CH3:21])([CH3:22])[S:23][CH2:24][CH2:25][CH2:26][OH:27].[CH3:28][C:29]([CH3:30])([CH3:31])Br>CC[N+](CC)(CC)Cc1ccccc1.CC(=O)N(C)C.O=C(O[K])O[K].[Cl-]>[CH3:1][C:2]#[C:3][CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:12](=[O:13])(=[O:14])[NH:15][C@@H:16]([C:17](=[O:18])[O:19][C:29]([CH3:28])([CH3:30])[CH3:31])[C:20]([CH3:22])([CH3:21])[S:23][CH2:24][CH2:25][CH2:26][OH:27]|US20190276449A1_0533
2.2.3|[C&H3&D1:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[S&H0&+0&D4:5](-[N&H1&+0&D2:2]-[c:1])(=[O&H0&D1:4])=[O&H0&D1:3]|[CH3:1][S:2](=[O:3])(=[O:4])Cl.[N:5]#[C:6][CH:7]=[CH:8][S:9](=[O:10])(=[O:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[NH2:18]>ClC(Cl)Cl.c1ccncc1>[CH3:1][S:2](=[O:3])(=[O:4])[NH:18][c:15]1[cH:16][cH:17][c:12]([cH:13][cH:14]1)[S:9](=[O:10])(=[O:11])[CH:8]=[CH:7][C:6]#[N:5]|EP3312172B1_0611
2.2.3|[C&H3&D1:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-Cl.[N&H2&+0&D1:2]-[N:1]>>[C&H3&D1:6]-[S&H0&+0&D4:5](-[N&H1&+0&D2:2]-[N:1])(=[O&H0&D1:4])=[O&H0&D1:3]|[CH3:1][S:2](=[O:3])(=[O:4])Cl.[NH2:5][NH:6][c:7]1[cH:8][cH:9][n:10][c:11]2[c:12]([cH:13][cH:14][cH:15][c:16]21)[NH:17][C:18](=[O:19])[c:20]1[c:21]([cH:22][cH:23][cH:24][c:25]1[Cl:26])[Cl:27]>CN(C)C=O.c1ccncc1>[CH3:1][S:2](=[O:3])(=[O:4])[NH:5][NH:6][c:7]1[cH:8][cH:9][n:10][c:11]2[c:12]([cH:13][cH:14][cH:15][c:16]21)[NH:17][C:18](=[O:19])[c:20]1[c:25]([cH:24][cH:23][cH:22][c:21]1[Cl:27])[Cl:26]|US20200165253A1_0607
2.7.2|[C:6]-[O&H1&+0&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[O&H1&D1:1])-Cl>>[C:6]-[O&H0&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[O&H1&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][C@@:5]([NH2:6])([CH2:7][OH:8])[CH2:9][CH3:10].[O:11]=[S:12](=[O:13])([OH:14])Cl>ClCCl>[CH3:1][CH2:2][CH2:3][CH2:4][C@:5]([NH2:6])([CH2:9][CH3:10])[CH2:7][O:8][S:12](=[O:11])(=[O:13])[OH:14]|US20200079770A1_1325
2.3.10|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-c1:c:c:c:c:c:1>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[c:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[CH3:9])[O:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[O:18]=[C:19]([NH:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[F:27])Oc1ccccc1>O.CCOC(C)=O.CN(C)C=O.[NaH]>[CH3:9][c:8]1[cH:7][c:6]([cH:5][cH:4][c:3]1[N:2]([CH3:1])[C:19](=[O:18])[NH:20][c:21]1[cH:26][cH:25][c:24]([cH:23][cH:22]1)[F:27])[O:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|EP3663285A1_0115
2.3.10|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[n:1])-O-c1:c:c:c:c:c:1>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[n:1]|[CH3:1][CH2:2][N:3]1[CH2:4][CH2:5][CH:6]([CH2:7][CH2:8]1)[NH:9][CH3:10].[CH3:11][O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[F:19])-[c:20]1[cH:21][n:22]([cH:23][n:24]1)[C:25](=[O:26])Oc1ccccc1>>[CH3:1][CH2:2][N:3]1[CH2:4][CH2:5][CH:6]([CH2:7][CH2:8]1)[N:9]([CH3:10])[C:25](=[O:26])[n:22]1[cH:23][n:24][c:20]([cH:21]1)-[c:16]1[cH:15][cH:14][c:13]([c:18]([cH:17]1)[F:19])[O:12][CH3:11]|US20190389895A1_0229
2.7.2|[N&H2&D1:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[N&H2&D1:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[NH2:1][S:2](=[O:3])(=[O:4])Cl.[OH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1>>[NH2:1][S:2](=[O:3])(=[O:4])[O:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1|US20170001964A1_0245
4.2.40|[O&H1&+0&D1:6]-[c:5]:[c:4]-[O&H1&+0&D1:3].[C&H2&+0&D2:2](-[C&H2&+0&D2:1]-Br)-Br>>[O&H0&+0&D2:6]1-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-[O&H0&+0&D2:3]-[c:4]:[c:5]-1|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[OH:11])[OH:12].Br[CH2:13][CH2:14]Br>[Na+].CO.C[O-]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[O:12][CH2:14][CH2:13][O:11][c:9]2[cH:10]1|EP3741752A1_0570
2.7.2|[C&H3&D1:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][S:2](=[O:3])(=[O:4])Cl.[CH3:5][C:6]1([c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[O:13][CH:14]1[N:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1)[OH:21])[CH3:22]>O.c1ccncc1>[CH3:5][C:6]1([c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[O:13][CH:14]1[N:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1)[O:21][S:2]([CH3:1])(=[O:3])=[O:4])[CH3:22]|US20200399263A1_0512
2.3.10|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-c1:c:c:c:c:c:1>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][NH:2][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7]1.[O:8]=[C:9]([NH:10][c:11]1[cH:12][cH:13][n:14][n:15][cH:16]1)Oc1ccccc1>C1CCOC1>[CH3:1][N:2]([C:9](=[O:8])[NH:10][c:11]1[cH:12][cH:13][n:14][n:15][cH:16]1)[CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7]1|US20200109126A1_0489
2.2.3|[C&H3&D1:6]-[S&H0&+0&D4:5](=[O&H0&D1:4])(=[O&H0&D1:3])-Cl.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[S&H0&+0&D4:5](-[N&H1&+0&D2:1]-[C:2])(=[O&H0&D1:4])=[O&H0&D1:3]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([CH2:7][CH2:8][CH2:9][NH2:10])[O:11][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][O:17]1.[CH3:18][S:19](=[O:20])(=[O:21])Cl>O.c1ccncc1>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH:6]([CH2:7][CH2:8][CH2:9][NH:10][S:19]([CH3:18])(=[O:20])=[O:21])[O:11][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][O:17]1|EP2785695B1_0621
2.1.1|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C:4].[Cl&H0&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[Cl&H0&D1:3])=[O&H0&D1:1]|[CH3:1][NH:2][CH:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[O:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21.[O:17]=[C:18]([Cl:19])Cl>CCN(CC)CC.Cc1ccccc1>[CH3:1][N:2]([C:18](=[O:17])[Cl:19])[CH:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[O:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21|US20130324555A1_0095
2.3.10|[C:6]-[N&H1&+0&D2:5]-[C:4].[N&H2&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-c1:c:c:c:c:c:1>>[C:6]-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[N&H2&D1:3])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([n:8]([n:9]1)[CH3:10])[NH:11][C:12](=[O:13])[NH:14][c:15]1[cH:16][c:17]([cH:18][c:19]([cH:20]1)[O:21][CH:22]1[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]1)[F:28].[NH2:29][C:30](=[O:31])Oc1ccccc1>CC(C)N(CC)C(C)C.CCOC(C)=O.O=C(O)O[Na].CS(C)=O>[CH3:10][n:8]1[n:9][c:5]([cH:6][c:7]1[NH:11][C:12](=[O:13])[NH:14][c:15]1[cH:16][c:17]([cH:18][c:19]([cH:20]1)[O:21][CH:22]1[CH2:23][CH2:24][N:25]([CH2:26][CH2:27]1)[C:30]([NH2:29])=[O:31])[F:28])[C:2]([CH3:1])([CH3:3])[CH3:4]|US09309224B2_0312
3.11.24|[O&H0&D1:7]=[C&H0&+0&D3:6](-[c:5])-[O&H0&+0&D2:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&D1:7]=[C&H0&+0&D3:6](-[c:5])-[c&H0&+0&D3:2](:[c:1]):[c:3]-[O&H1&+0&D1:4]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)[O:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[CH3:17])[CH3:18]>O.Cl.[O-][N+](=O)c1ccccc1.Cl[Al](Cl)Cl>[CH3:17][c:14]1[cH:15][cH:16][c:11]([cH:12][cH:13]1)[C:9](=[O:10])[c:5]1[c:4]([cH:3][c:2]([cH:7][c:6]1[OH:8])[CH3:1])[CH3:18]|US20150246902A1_0273
1.2.18|[C&H3&D1:6]-[C&H0&+0&D3:5](-[C&H2&+0&D2:4]-[C:3])=O.[C&H3&D1:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[C&H0&+0&D3:5](-[N&H1&+0&D2:1]-[C&H3&D1:2])=[C&H1&+0&D2:4]-[C:3]|CO.[CH3:1][O:2][C:3](=[O:4])[CH2:5][C:6]([CH3:7])=O.[CH3:8][NH2:9]>CO>[CH3:1][O:2][C:3](=[O:4])[CH:5]=[C:6]([CH3:7])[NH:9][CH3:8]|US09199913B2_0051
1.7.12|[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C&H3&D1:4])-[C&H3&D1:3].[O&H1&+0&D1:2]-[c:1]>>[C&H3&+0&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C&H3&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH2:1]=[C:2]([CH3:3])[CH3:4].[O-:5][N+:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[CH2:14][O:15][C:16](=[O:17])[CH2:18][CH2:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[OH:26]>[O-]C(=O)O.O=S(=O)(O)O.ClCCl.[K+]>[CH3:3][C:2]([CH3:4])([CH3:1])[O:26][c:23]1[cH:24][cH:25][c:20]([cH:21][cH:22]1)[CH2:19][CH2:18][C:16](=[O:17])[O:15][CH2:14][c:11]1[cH:12][cH:13][c:8]([cH:9][cH:10]1)[N+:6]([O-:5])=[O:7]|US20040009980A1_0090
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-[O&-]>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][NH:2][CH3:3].[O-][C:4](=[O:5])[c:6]1[cH:7][c:8]2[n:9][cH:10][cH:11][c:12]([c:13]2[s:14]1)[Cl:15].[Li+]>>[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[c:6]1[cH:7][c:8]2[n:9][cH:10][cH:11][c:12]([c:13]2[s:14]1)[Cl:15]|US20200385375A1_0513
2.2.3|[C:7]-[N&H2&+&D2:6]-[C:5].[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[O:1]=[S:2](=[O:3])(Cl)[CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:11][O:12][C:13](=[O:14])[C@@H:15]1[CH2:16][CH2:17][NH2+:18]1.[Cl-]>CC(C)N(CC)C(C)C.ClCCl>[CH3:11][O:12][C:13](=[O:14])[C@@H:15]1[CH2:16][CH2:17][N:18]1[S:2](=[O:1])(=[O:3])[CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|US10875850B2_0128
2.1.2|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[O&-]>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[C:7]([NH:8][C:9](=[C:10]([CH:11]1[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[N+:18]([O-:19])=[O:20])[C:21](=[O:22])[O:23][CH2:24][CH3:25])[C:26]([O-])=[O:27])[CH3:28].[CH3:29][NH:30][CH3:31]>c1ccccc1.CN(C)C=O.O=S(Cl)Cl.ClCCl>[CH3:25][CH2:24][O:23][C:21](=[O:22])[C:10]1=[C:9]([NH:8][C:7](=[C:6]([CH:11]1[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[N+:18]([O-:19])=[O:20])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[CH3:28])[C:26](=[O:27])[N:30]([CH3:29])[CH3:31]|US20120101083A1_1053
4.1.13|[N&H2&+0&D1:6]-[N&H2&+0&D1:5].[n:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-Cl>>[n&H0&+0&D2:6]1:[n&H1&+0&D2:5]:[c&H0&+0&D3:3](:[n:4]):[c:2]:[c&H1&+0&D2:1]:1|[NH2:1][c:2]1[n:3][c:4]([c:5]([c:6]([n:7]1)[Cl:8])[CH:9]=O)Cl.[NH2:10][NH2:11]>CCN(CC)CC.C1CCOC1.NN.O>[NH2:1][c:2]1[n:7][c:6]([c:5]2[cH:9][n:10][nH:11][c:4]2[n:3]1)[Cl:8]|US20200062760A1_0176
4.1.12|[N&H2&+0&D1:6]-[c:5]:[n&H0&+0&D2:4]:[n:3].[C&H1&+0&D2:2](-[C&H2&+0&D2:1]-Cl)=O>>[n&H0&+0&D2:6]1:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:[n&H0&+0&D3:4](:[n:3]):[c:5]:1|[CH3:1][c:2]1[cH:3][c:4]([n:5][n:6][c:7]1[Cl:8])[NH2:9].O=[CH:10][CH2:11]Cl>>[CH3:1][c:2]1[cH:3][c:4]2[n:9][cH:10][cH:11][n:5]2[n:6][c:7]1[Cl:8]|US20130237535A1_0610
3.11.24|[C:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[O&H0&+0&D2:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[c&H0&+0&D3:2](:[c:1]):[c:3]-[O&H1&+0&D1:4]|[CH3:1][CH2:2][C:3]([CH3:4])([CH3:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][C:13](=[O:14])[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>>[CH3:1][CH2:2][C:3]([CH3:4])([CH3:5])[c:6]1[cH:11][cH:10][c:9]([c:8]([cH:7]1)[C:13](=[O:14])[CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[OH:12]|EP2168959A1_0923
3.11.91|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C&H3&D1:5])-I.[C:4]-[C&H1&+0&D3:3](-[C:2])-[C:1]>>[C&H3&D1:7]-[C&H1&+0&D3:6](-[C&H3&D1:5])-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][CH2:8][C:9]1=[O:10].[CH3:11][CH:12]([CH3:13])I>Cl.CN(C)C=O.[NaH]>[CH3:1][O:2][C:3](=[O:4])[C:5]1([CH2:6][CH2:7][CH2:8][C:9]1=[O:10])[CH:12]([CH3:11])[CH3:13]|US07361765B2_0028
1.7.12|[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C&H3&D1:4])-[C&H3&D1:3].[C:2]-[O&H1&+0&D1:1]>>[C&H3&+0&D1:6]-[C&H0&+0&D4:5](-[C&H3&D1:4])(-[C&H3&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH2:1]=[C:2]([CH3:3])[CH3:4].[CH3:5][CH2:6][CH2:7][C:8]#[C:9][CH:10]([OH:11])[CH2:12][CH2:13][I:14]>>[CH3:5][CH2:6][CH2:7][C:8]#[C:9][CH:10]([CH2:12][CH2:13][I:14])[O:11][C:2]([CH3:3])([CH3:1])[CH3:4]|US20060154922A1_0131
2.2.4|[C:7]-[N&H1&+0&D2:6]-[C:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-O>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][N:2]1[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1.[CH3:8][CH2:9][n:10]1[c:11]([n:12]([c:13]([c:14]2[nH:15][c:16]([n:17][c:18]21)-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[S:25](=[O:26])(=[O:27])O)=[O:28])[CH2:29][CH3:30])=[O:31]>CN(C)C=O.O=S(Cl)Cl>[CH3:30][CH2:29][n:12]1[c:13]([c:14]2[nH:15][c:16]([n:17][c:18]2[n:10]([c:11]1=[O:31])[CH2:9][CH3:8])-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[S:25](=[O:26])(=[O:27])[N:5]1[CH2:4][CH2:3][N:2]([CH2:7][CH2:6]1)[CH3:1])=[O:28]|US20110046127A1_0656
1.7.12|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C:5])=[C&H1&+0&D2:4]-[C:3].[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H0&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[C:3]|[CH3:1][CH:2]([CH3:3])[CH:4]([OH:5])[CH:6]1[CH2:7][CH2:8][C:9](=[CH:10][CH:11]1[CH3:12])[CH3:13]>O.Cl.CC(C)O.Cc1ccccc1>[CH3:12][CH:11]1[CH2:10][C:9]2([CH2:8][CH2:7][CH:6]1[CH:4]([O:5]2)[CH:2]([CH3:1])[CH3:3])[CH3:13]|US09441185B2_0171
10.4.3|[O&H2&+0&D0:6].[C&H3&D1:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=[C&H1&+0&D2:2]-[C:1]>>[O&H1&+0&D1:6]-[C&H0&+0&D4:4](-[C&H3&D1:5])(-[C&H3&D1:3])-[C&H2&+0&D2:2]-[C:1]|[OH2:1].O.[CH2:2]=[CH:3][C:4](=[CH2:5])[CH2:6][CH2:7][CH:8]=[C:9]([CH3:10])[CH3:11]>Cl.C=CC(=C)CCC1OC1(C)C>[CH2:2]=[CH:3][C:4](=[CH2:5])[CH2:6][CH2:7][CH2:8][C:9]([CH3:10])([CH3:11])[OH:1]|EP3230245B1_0069
4.1.13|[N&H2&+0&D1:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-Cl>>[n&H0&+0&D2:6]1:[n&H1&+0&D2:5]:[c&H0&+0&D3:3](:[c:4]):[c:2]:[c&H1&+0&D2:1]:1|O.[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([n:7]1)[Cl:8])[CH:9]=O)Cl.[NH2:10][NH2:11]>ClCCCl>[CH3:1][c:2]1[cH:3][c:4]2[nH:11][n:10][cH:9][c:5]2[c:6]([n:7]1)[Cl:8]|US20160222014A1_0193
4.1.12|[N&H2&+0&D1:6]-[c:5]:[n&H0&+0&D2:4]:[c:3].[C&H1&+0&D2:2](-[C&H2&+0&D2:1]-Cl)=O>>[n&H0&+0&D2:6]1:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:[n&H0&+0&D3:4](:[c:3]):[c:5]:1|[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[CH:7]([OH:8])[C@H:9]1[O:10][C@H:11]([C@@H:12]([C@@H:13]1[OH:14])[OH:15])[n:16]1[cH:17][n:18][c:19]2[c:20]1[n:21][cH:22][n:23][c:24]2[NH2:25].O=[CH:26][CH2:27]Cl>>[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[CH:7]([OH:8])[C@H:9]1[O:10][C@H:11]([C@@H:12]([C@@H:13]1[OH:14])[OH:15])[n:16]1[cH:17][n:18][c:19]2[c:20]1[n:21][cH:22][n:23]1[cH:27][cH:26][n:25][c:24]21|US07144907B2_0288
4.3.9|[N&H0&+0&D1:6]#[C&H0&+0&D2:5]-[S&H0&+0&D2:4]-[c:3]:[c:2]-[N&H0&+&D3:1](-[O&-])=O>>[N&H2&+0&D1:6]-[c&H0&+0&D3:5]1:[s&H0&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D2:1]:1|[N:1]#[C:2][S:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[N+:10]([O-])=O)[N+:11]([O-:12])=[O:13]>O.CN(C)C=O.NC(N)=S>[NH2:1][c:2]1[n:10][c:9]2[cH:8][c:7]([cH:6][cH:5][c:4]2[s:3]1)[N+:11]([O-:12])=[O:13]|US20060235222A1_0867
7.6.1|[C&H3&D1:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c:4]:[c:3]:[n&H0&+0&D3:2]:1-[C:1]>>[C&H3&D1:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[c:4]:[c:3]-[N&H0&+0&D3:2]-1-[C:1]|[CH3:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([cH:7][cH:8][c:9]2[n:10]1[CH2:11][c:12]1[n:13][c:14]([o:15][c:16]1[CH3:17])-[c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[C:24](=[O:25])[O:26][CH3:27])[C:28]([OH:29])([C:30]([F:31])([F:32])[F:33])[C:34]([F:35])([F:36])[F:37]>>[CH3:27][O:26][C:24](=[O:25])[c:22]1[cH:21][cH:20][cH:19][c:18]([cH:23]1)-[c:14]1[n:13][c:12]([c:16]([o:15]1)[CH3:17])[CH2:11][N:10]1[c:9]2[cH:8][cH:7][c:6]([cH:5][c:4]2[CH2:3][CH:2]1[CH3:1])[C:28]([OH:29])([C:30]([F:31])([F:32])[F:33])[C:34]([F:35])([F:36])[F:37]|US07572820B2_1060
9.7.56|[O&H0&D1:6]=[C&H0&+0&D3:5](-[N&H0&+0&D2:4]=[N&+]=[N&-])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[O&H0&D1:6]=[C&H0&+0&D2:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[C:14](=[O:15])[N:16]=[N+]=[N-])([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[N:16]=[C:14]=[O:15])([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|US20060094716A1_0170
4.1.45|[C:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[O:2]-[C&H0&+0&D4:1](-O-C)(-O-C)-O-C>>[C:7]-[n&H0&+0&D3:6]1:[c:5]:[c:4]:[n&H0&+0&D2:3]:[c&H0&+0&D3:1]:1-[O:2]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[C:22](=[O:23])[NH:24][S:25](=[O:26])(=[O:27])[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.CO[C:34]([O:35][CH3:36])(OC)OC>CC(=O)O.CO>[CH3:36][O:35][c:34]1[n:1][c:2]2[cH:3][cH:4][c:5]([cH:6][c:7]2[n:8]1[CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)-[c:16]1[cH:21][cH:20][cH:19][cH:18][cH:17]1)[C:22](=[O:23])[NH:24][S:25](=[O:26])(=[O:27])[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1|US10807982B2_0852
4.1.45|[C:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[C:2]-[C&H0&+0&D4:1](-O-C)(-O-C)-O-C>>[C:7]-[n&H0&+0&D3:6]1:[c:5]:[c:4]:[n&H0&+0&D2:3]:[c&H0&+0&D3:1]:1-[C:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][c:14]1[c:15]2[n:16][cH:17][cH:18][cH:19][c:20]2[n:21][cH:22][c:23]1[NH2:24].CO[C:25]([CH2:26][CH2:27][CH2:28][CH3:29])(OC)OC>Cc1ccc(cc1)S(=O)(=O)OS(=O)(=O)c1ccc(cc1)C.Cc1ccccc1C.CCOC(C)=O.O>[CH3:29][CH2:28][CH2:27][CH2:26][c:25]1[n:24][c:23]2[cH:22][n:21][c:20]3[cH:19][cH:18][cH:17][n:16][c:15]3[c:14]2[n:13]1[CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20200354350A1_1119
2.2.3|[C:7]-[N&H1&+0&D2:6]-[C:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[S:12](=[O:13])(=[O:14])Cl.[CH3:15][O:16][CH:17]1[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]1>CCN(CC)CC.CC(C)=O>[CH3:15][O:16][CH:17]1[CH2:18][CH2:19][N:20]([CH2:21][CH2:22]1)[S:12](=[O:13])(=[O:14])[c:8]1[cH:7][cH:6][c:5]([c:10]([cH:9]1)[Cl:11])[S:2]([NH2:1])(=[O:3])=[O:4]|US20130336920A1_1249
2.2.3|[N&H2&+0&D1:6]-[N&H2&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[N&H1&+0&D2:6](-[N&H2&D1:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[NH2:1][NH2:2].[O:3]=[S:4](=[O:5])(Cl)[c:6]1[cH:7][cH:8][cH:9][c:10]2[cH:11][cH:12][cH:13][n:14][c:15]21>CO>[NH2:2][NH:1][S:4](=[O:3])(=[O:5])[c:6]1[cH:7][cH:8][cH:9][c:10]2[cH:11][cH:12][cH:13][n:14][c:15]21|EP3757091A1_0308
2.2.3|[N&H2&+0&D1:6]-[O&H1&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[N&H1&+0&D2:6](-[O&H1&D1:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[cH:9][c:10]([n:11][n:12]1-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[S:19](=[O:20])(=[O:21])Cl)[C:22]([F:23])([F:24])[F:25].[NH2:26][OH:27].Cl>C1COCCO1.O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[cH:9][c:10]([n:11][n:12]1-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[S:19](=[O:20])(=[O:21])[NH:26][OH:27])[C:22]([F:23])([F:24])[F:25]|US20070093539A1_0064
3.7.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Br>>[C:7]-[C&H0&+0&D4:6](-[O&H1&+0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([C:3]1=[N:4][CH2:5][CH:6]2[CH2:7][CH2:8][CH2:9][CH2:10][N:11]12)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.Br[Mg][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>[NH4+].[NH4+].[Cl-].CCOCC>[OH:1][C:2]([C:3]1=[N:4][CH2:5][CH:6]2[CH2:7][CH2:8][CH2:9][CH2:10][N:11]12)([c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1)[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|EP0123998A2_0062
2.2.3|[C:6]-[N&H2&+0&D1:5].[Cl&H0&D1:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:6]-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](-[Cl&H0&D1:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[NH2:5].[O:6]=[S:7](=[O:8])([Cl:9])Cl>CC#N.Cl>[CH3:1][C:2]([CH3:3])([CH3:4])[NH:5][S:7](=[O:6])(=[O:8])[Cl:9]|US20090275606A1_0685
3.7.3|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Cl>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH2:1]=[CH:2][CH2:3][c:4]1[cH:5][c:6]2[O:7][C@@H:8]3[CH2:9][C:10]([CH2:11][CH2:12][C@H:13]3[c:14]2[cH:15][c:16]1[OH:17])=[O:18].Cl[Mg][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>>[CH2:1]=[CH:2][CH2:3][c:4]1[cH:5][c:6]2[O:7][C@@H:8]3[CH2:9][C:10]([CH2:11][CH2:12][C@H:13]3[c:14]2[cH:15][c:16]1[OH:17])([OH:18])[c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1|EP0681569B1_0054
2.2.3|[N:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[N:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[S:2](=[O:3])([O:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[C:11]([F:12])([F:13])[F:14])[c:15]1[n:16][cH:17][nH:18][n:19]1.[CH3:20][N:21]([CH3:22])[S:23](=[O:24])(=[O:25])Cl>O=C(O[K])O[K].CC#N.O>[CH3:20][N:21]([CH3:22])[S:23](=[O:24])(=[O:25])[n:18]1[cH:17][n:16][c:15]([n:19]1)[S:2](=[O:1])(=[O:3])[O:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[C:11]([F:12])([F:13])[F:14]|US20200361939A1_1887
2.2.3|[N:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[N:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[n:6][cH:7][nH:8][c:9]2[cH:10][c:11]1[O:12][CH3:13].[CH3:14][N:15]([CH3:16])[S:17](=[O:18])(=[O:19])Cl>CCN(CC)CC.CC(Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][c:5]2[n:6][cH:7][n:8]([c:9]2[cH:10][c:11]1[O:12][CH3:13])[S:17](=[O:18])(=[O:19])[N:15]([CH3:14])[CH3:16]|EP2913333A1_0390
1.6.2|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C:4])-Br.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[C:13](=[O:14])[C:15]([CH3:16])([CH3:17])Br.[cH:18]1[cH:19][c:20]([cH:21][cH:22][n:23]1)[N:24]1[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]1>CC#N>[CH3:1][O:2][C:3](=[O:4])[CH2:5][O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[C:13](=[O:14])[C:15]([CH3:16])([CH3:17])[N:27]1[CH2:28][CH2:29][N:24]([CH2:25][CH2:26]1)[c:20]1[cH:21][cH:22][n:23][cH:18][cH:19]1|US20200347071A1_1473
1.6.2|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C:4])-Br.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2](=[O:3])[C:4]([CH3:5])([CH3:6])Br.[cH:7]1[cH:8][cH:9][nH:10][n:11]1>>[CH3:1][C:2](=[O:3])[C:4]([CH3:5])([CH3:6])[n:10]1[cH:9][cH:8][cH:7][n:11]1|US20190375717A1_0197
2.2.3|[C:7]-[N&H1&+0&D2:6]-[N:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[N:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[NH:5][NH:6][C:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[O:15]=[S:16](=[O:17])(Cl)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>c1ccncc1.CCOCC>[CH3:1][C:2]([CH3:3])([CH3:4])[N:5]([NH:6][C:7](=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[S:16](=[O:15])(=[O:17])[c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1|US08252781B2_1463
3.7.3|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-[#12]-Cl>>[C:7]-[C&H0&+0&D4:6](-[O&H1&+0&D1:5])(-[c:4])-[C&H1&+0&D3:2](-[C:3])-[C:1]|[O:1]=[C:2]([CH2:3][CH2:4][CH2:5][Cl:6])[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.Cl[Mg][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1>CCOCC.Cl[Na]>[OH:1][C:2]([CH2:3][CH2:4][CH2:5][Cl:6])([c:7]1[cH:12][cH:11][cH:10][cH:9][cH:8]1)[CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1|US07745439B2_0128
3.11.86|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C&H3&D1:5])-[C:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[CH3:9])Br)[N:10]([CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[C:18](=[O:19])[CH:20]([CH3:21])[CH3:22]>C1CCC(CC1)P(C1CCCCC1)C1CCCCC1.CC(C)(C)O[Na].C1COCCO1.CC([O-])=O.CC([O-])=O.[NH4+].[Cl-].[Pd+2]>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([cH:7][c:8]1[CH3:9])[C:20]([C:18]([N:10]2[CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)=[O:19])([CH3:21])[CH3:22]|US20070149525A1_0441
2.2.3|[C:7]-[N&H1&+0&D2:6]-[c:5].[N:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[c:5])-[S&H0&+0&D4:3](-[N:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])Cl.[Cl:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[NH:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][n:20][cH:21]1>O=C(O[K])O[K].ClCCl>[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])[N:14]([CH2:15][c:16]1[cH:21][n:20][cH:19][cH:18][cH:17]1)[c:11]1[cH:12][cH:13][c:8]([cH:9][cH:10]1)[Cl:7]|US09663502B2_1192
2.1.2|[C:7]-[N&H1&+0&D2:6]-[N&H1&+0&D2:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:7]-[n&H0&+0&D3:6]1:[n&H1&+0&D2:5]:[c:4]:[c:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1]|[O:1]=[C:2](O)[c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[NH:9][NH:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[Cl:18]>CC(=O)O.CCOCC>[O:1]=[c:2]1[c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[nH:9][n:10]1[CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[Cl:18]|US20190106427A1_0736
2.7.2|[C:6]-[O&H1&+0&D1:5].[Cl&H0&D1:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:6]-[O&H0&+0&D2:5]-[S&H0&+0&D4:3](-[Cl&H0&D1:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH2:4][O:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[CH2:14][OH:15].[O:16]=[S:17](=[O:18])([Cl:19])Cl>CCOCC.c1ccncc1>[CH3:1][C:2]([CH3:3])([CH2:4][O:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[CH2:14][O:15][S:17](=[O:16])(=[O:18])[Cl:19]|US10280161B2_1110
3.7.2|[C:7]-[C&H0&+0&D3:6](-[N:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Br>>[C:7]-[C&H0&+0&D4:6](-[N:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[C@@H:5]1[CH2:6][C@H:7]([C:8]([N:9]1[C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:17])[O:18][Si:19]([CH3:20])([CH3:21])[C:22]([CH3:23])([CH3:24])[CH3:25].Br[Mg][c:26]1[cH:27][cH:28][cH:29][cH:30][c:31]1[O:32][CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1>>[CH3:23][C:22]([CH3:24])([CH3:25])[Si:19]([CH3:20])([CH3:21])[O:18][C@@H:7]1[CH2:6][C@H:5]([N:9]([C:8]1([OH:17])[c:26]1[cH:27][cH:28][cH:29][cH:30][c:31]1[O:32][CH2:33][c:34]1[cH:39][cH:38][cH:37][cH:36][cH:35]1)[C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[C:3](=[O:4])[O:2][CH3:1]|US08637516B2_0364
2.2.3|[C:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[S:4](=[O:5])(=[O:6])Cl.[NH2:7][c:8]1[n:9][c:10]2[c:11]([nH:12]1)[c:13]([n:14]([c:15]([n:16]2[CH2:17][CH:18]1[CH2:19][CH2:20]1)=[O:21])[CH2:22][CH:23]1[CH2:24][CH2:25]1)=[O:26]>O.COCCOC.CCOC(C)=O.[NaH]>[CH3:1][CH:2]([CH3:3])[S:4](=[O:5])(=[O:6])[n:12]1[c:8]([n:9][c:10]2[c:11]1[c:13]([n:14]([c:15]([n:16]2[CH2:17][CH:18]1[CH2:19][CH2:20]1)=[O:21])[CH2:22][CH:23]1[CH2:24][CH2:25]1)=[O:26])[NH2:7]|US20200024281A1_0174
2.2.3|[C:7]-[N&H1&+0&D2:6]-[C:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[O:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[O:1]|[CH3:1][C:2]([CH3:3])([O:4]/[N:5]=[C:6](/[C:7](=[O:8])[NH:9][C@@H:10]1[C:11]([NH:12][C@H:13]1[CH3:14])=[O:15])[c:16]1[cH:17][s:18][c:19]([n:20]1)[NH2:21])[C:22](=[O:23])[OH:24].[CH3:25][C:26]([CH3:27])([CH2:28][O:29][C:30](=[O:31])[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)[CH2:38][O:39][S:40](=[O:41])(=[O:42])Cl>>[CH3:1][C:2]([CH3:3])([O:4]/[N:5]=[C:6](/[C:7](=[O:8])[NH:9][C@@H:10]1[C:11]([N:12]([C@H:13]1[CH3:14])[S:40](=[O:41])(=[O:42])[O:39][CH2:38][C:26]([CH3:25])([CH3:27])[CH2:28][O:29][C:30](=[O:31])[c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)=[O:15])[c:16]1[cH:17][s:18][c:19]([n:20]1)[NH2:21])[C:22](=[O:23])[OH:24]|US10280161B2_1116
4.1.45|[C&H3&D1:6]-[C&H0&+0&D4:5](-O-C)(-O-C)-O-C.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C:9]1([CH2:10][CH2:11][CH2:12]1)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)-[c:19]1[c:20]([c:21]2[cH:22][cH:23][c:24]([c:25]([c:26]2[o:27][c:28]1-[c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)[NH2:35])[NH2:36])=[O:37].CO[C:38]([CH3:39])(OC)OC>CC#N.II>[CH3:3][C:2]([CH3:4])([CH3:1])[O:5][C:6](=[O:7])[NH:8][C:9]1([CH2:10][CH2:11][CH2:12]1)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)-[c:19]1[c:28]([o:27][c:26]2[c:21]([cH:22][cH:23][c:24]3[n:36][c:38]([nH:35][c:25]23)[CH3:39])[c:20]1=[O:37])-[c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1|US06291203B1
2.2.3|[N&H2&+0&D1:6]-[c:5].[N&H2&D1:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[N&H1&+0&D2:6](-[c:5])-[S&H0&+0&D4:3](-[N&H2&D1:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[NH2:1][c:2]1[n:3][nH:4][c:5]([c:6]1-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[F:13])-[c:14]1[cH:15][cH:16][n:17][cH:18][cH:19]1.[NH2:20][S:21](=[O:22])(=[O:23])Cl>CCN(CC)CC.O=C=NS(=O)(=O)Cl.c1ccccc1.NS(=O)(=O)Cl.CC#N.[NH4+].O.[OH-]>[NH2:20][S:21](=[O:22])(=[O:23])[NH:1][c:2]1[n:3][nH:4][c:5]([c:6]1-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[F:13])-[c:14]1[cH:15][cH:16][n:17][cH:18][cH:19]1|US08633186B2_1673
3.7.2|[O&H0&+0&D1:7]=[C&H0&+0&D3:6](-[c:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Br>>[O&H1&+0&D1:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[Mg]Br.[O:8]=[C:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[c:16]1[cH:17][cH:18][n:19][cH:20][cH:21]1>[NH4+].[Cl-].CCOCC>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:9]([OH:8])([c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1)[c:16]1[cH:17][cH:18][n:19][cH:20][cH:21]1|US20100056565A1_0328
2.2.3|[O&H0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[O&H0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[S:2](=[O:3])(Cl)[c:4]1[cH:5][nH:6][cH:7][n:8]1.[cH:9]1[cH:10][nH:11][cH:12][n:13]1>C1CCOC1>[O:1]=[S:2](=[O:3])([c:4]1[cH:5][nH:6][cH:7][n:8]1)[n:11]1[cH:10][cH:9][n:13][cH:12]1|US08048909B2_1209
2.2.3|[C:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH2:2][S:3](=[O:4])(=[O:5])Cl.[O:6]=[C:7]1[NH:8][CH2:9][CH2:10][NH:11]1>CCOC(C)=O.c1ccccc1.CC(C)=O.Cl>[CH3:1][CH2:2][S:3](=[O:4])(=[O:5])[N:8]1[CH2:9][CH2:10][NH:11][C:7]1=[O:6]|US05389633A
1.6.4|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[CH:14]#[C:15][C:16]([CH3:17])([CH3:18])Cl>CCOCC.Cl[Cu].O.[Cu]>[CH:14]#[C:15][C:16]([CH3:17])([CH3:18])[N:11]1[CH2:10][CH2:9][N:8]([CH2:13][CH2:12]1)[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20200039943A1_0783
2.2.3|[C:7]-[N&H1&+0&D2:6]-[O:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[O:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]1[O:10][NH:11][CH:12]([CH:13]=[C:14]1[CH3:15])[CH3:16].[CH3:17][C:18](=[O:19])[NH:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[S:27](=[O:28])(=[O:29])Cl.Cl>CCN(CC)CC.ClCCl>[CH3:17][C:18](=[O:19])[NH:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[S:27](=[O:28])(=[O:29])[N:11]1[O:10][CH:9]([C:14](=[CH:13][CH:12]1[CH3:16])[CH3:15])[c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[O:2][CH3:1]|US10245249B2_0449
2.2.3|[C:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][n:5]1[c:6]([n:7]([c:8]([c:9]2[nH:10][n:11][cH:12][c:13]21)=[O:14])[CH2:15][CH2:16][CH2:17][CH3:18])=[O:19].[CH3:20][CH2:21][CH2:22][S:23](=[O:24])(=[O:25])Cl>CCOC(C)=O.ClCCl.ClCCl>[CH3:18][CH2:17][CH2:16][CH2:15][n:7]1[c:6]([n:5]([c:13]2[cH:12][n:11][n:10]([c:9]2[c:8]1=[O:14])[S:23](=[O:24])(=[O:25])[CH2:22][CH2:21][CH3:20])[CH2:4][CH2:3][CH2:2][CH3:1])=[O:19]|US20200361939A1_1842
3.11.86|[C:7]-[C&H1&+0&D3:6](-[F&H0&D1:5])-[F&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[CH:9]([F:10])[F:11].Br[c:12]1[cH:13][n:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[cH:21]1>>[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[C:9]([F:10])([F:11])[c:12]1[cH:13][n:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[cH:21]1|US10307426B2_0399
4.3.6|[c:6]:[c&H1&+0&D2:5]:[c:4]-[S&H0&+0&D2:3]-[C&H2&+0&D2:2]-[C&H1&+0&D3:1](-O-C)-O-C>>[c:6]:[c&H0&+0&D3:5]1:[c:4]:[s&H0&+0&D2:3]:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:1|CO[CH:1]([CH2:2][S:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[F:10])OC>Clc1ccccc1>[F:10][c:7]1[cH:6][cH:5][c:4]2[s:3][cH:2][cH:1][c:9]2[cH:8]1|US20190367520A1_0339
3.7.2|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Br>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5]1.Br[Mg][c:6]1[cH:7][cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[cH:15]1>Cl.CCOCC>[OH:1][C:2]1([CH2:3][CH2:4][CH2:5]1)[c:6]1[cH:7][cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[cH:15]1|US10562850B2_0370
2.2.3|[C:7]-[N&H1&+0&D2:6]-[C:5].[N:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](-[N:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])Cl.[O:7]=[C:8]1[NH:9][CH2:10][CH2:11][NH:12]1>>[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])[N:12]1[CH2:11][CH2:10][NH:9][C:8]1=[O:7]|US20060167001A1_0340
2.2.3|[C:7]-[N&H1&+0&D2:6]-[c:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[c:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[O:1]=[C:2]([OH:3])[CH2:4][NH:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1.[O:12]=[S:13](=[O:14])(Cl)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O.O[Na].ClC(Cl)Cl>[O:1]=[C:2]([OH:3])[CH2:4][N:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[S:13](=[O:12])(=[O:14])[c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|US09809561B2_1432
4.1.45|[C&H3&D1:6]-[N&H1&+0&D2:5]-[c:4]:[c:3]-[N&H2&+0&D1:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[C&H3&D1:6]-[n&H0&+0&D3:5]1:[c:4]:[c:3]:[n&H0&+0&D2:2]:[c&H1&+0&D2:1]:1|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[NH2:11])[NH:12][CH3:13].CO[CH:14](OC)OC>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[n:11][cH:14][n:12]2[CH3:13]|US20080221097A1_0263
2.2.3|[C:7]-[N&H1&+0&D2:6]-[c:5].[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[c:5])-[S&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[NH:12][CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20].[CH3:21][CH2:22][O:23][C:24](=[O:25])[CH2:26][S:27](=[O:28])(=[O:29])Cl>Cc1ccccc1.CCN(CC)CC.O.O>[CH3:21][CH2:22][O:23][C:24](=[O:25])[CH2:26][S:27](=[O:28])(=[O:29])[N:12]([CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[Cl:20])[c:11]1[cH:10][cH:9][cH:8][cH:7][c:6]1[CH2:5][C:3](=[O:4])[O:2][CH3:1]|EP2655360B1_0141
4.1.45|[C&H3&D1:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[C:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:7]-[n&H0&+0&D3:6]1:[c&H0&+0&D3:1](-[C:2]):[n&H0&+0&D2:3]:[c:4]:[c:5]:1|[CH3:1][NH:2][c:3]1[n:4][cH:5][c:6]([cH:7][c:8]1[NH2:9])[C:10]([F:11])([F:12])[F:13].[O:14]=[C:15]1[NH:16][C:17]([CH:18]([S:19]1)[CH2:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[O:27][CH2:28][CH:29]=O)=[O:30]>CCO.CC(=O)O>[CH3:1][n:2]1[c:29]([n:9][c:8]2[cH:7][c:6]([cH:5][n:4][c:3]21)[C:10]([F:11])([F:12])[F:13])[CH2:28][O:27][c:24]1[cH:25][cH:26][c:21]([cH:22][cH:23]1)[CH2:20][CH:18]1[S:19][C:15]([NH:16][C:17]1=[O:30])=[O:14]|US20200331888A1_0814
2.2.3|[O&H0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[O&H0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[S:2](=[O:3])(Cl)[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[cH:10]1[cH:11][c:12]([cH:13][cH:14][n:15]1)-[c:16]1[n:17][c:18]([n:19][nH:20]1)-[c:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1>C1CCOC1.[NaH]>[O:1]=[S:2](=[O:3])([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[n:20]1[n:19][c:18]([n:17][c:16]1-[c:12]1[cH:11][cH:10][n:15][cH:14][cH:13]1)-[c:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1|US20100152177A1_0875
4.2.17|[C&H3&D1:6]-[C&H0&+0&D4:5](-O-C)(-O-C)-O-C.[N&H2&+0&D1:4]-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[o&H0&+0&D2:1]:1|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[OH:11])[NH2:12].CO[C:13]([CH3:14])(OC)OC>O=S(=O)(O)O.CO>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:10][c:9]2[o:11][c:13]([n:12][c:8]2[cH:7][cH:6]1)[CH3:14]|US20150266857A1_0727
1.6.8|[C&H3&D1:7]-[C&H2&+0&D2:6]-I.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[C&H3&D1:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|[CH3:1][CH2:2]I.[Cl:3][c:4]1[n:5][cH:6][n:7][c:8]2[n:9][cH:10][nH:11][c:12]12>O.CS(C)=O.O=C(O[K])O[K]>[CH3:1][CH2:2][n:9]1[cH:10][n:11][c:12]2[c:4]([n:5][cH:6][n:7][c:8]21)[Cl:3]|US20150376219A1_0142
3.11.39|[C&H1&+0&D1:6]#[C:5].[C&H3&D1:4]-[C&H0&+0&D3:3](-[C&H3&D1:2])=[O&H0&+0&D1:1]>>[C&H0&+0&D2:6](#[C:5])-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C&H3&D1:2])-[O&H1&+0&D1:1]|[CH:1]#[C:2][c:3]1[n:4][cH:5][n:6]2[c:7]1[CH2:8][N:9]([C:10]([c:11]1[cH:12][c:13]([cH:14][cH:15][c:16]1-2)[F:17])=[O:18])[CH3:19].[CH3:20][C:21]([CH3:22])=[O:23]>CN(C)P(=O)(N(C)C)N(C)C.CCCCCC.CCCC[Li].C1CCOC1.O>[CH3:19][N:9]1[CH2:8][c:7]2[c:3]([n:4][cH:5][n:6]2-[c:16]2[cH:15][cH:14][c:13]([cH:12][c:11]2[C:10]1=[O:18])[F:17])[C:2]#[C:1][C:21]([CH3:20])([CH3:22])[OH:23]|US10597401B2_1349
1.2.17|[C:8]-[C&H1&+0&D2:7]=[C&H0&+0&D3:6](-[C:5])-[C:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:8]-[C&H2&+0&D2:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][CH2:8][n:9]1[cH:10][cH:11][c:12]2[c:13]1[n:14][cH:15][n:16][c:17]2-[c:18]1[cH:19][cH:20][nH:21][cH:22]1.[CH3:23][C:24]([CH3:25])([CH3:26])[O:27][C:28](=[O:29])[N:30]1[CH2:31]/[C:32]([CH2:33]1)=[CH:34]\[C:35]#[N:36]>C1CN2CCCCCC2=NC1.CC#N>[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][CH2:8][n:9]1[cH:10][cH:11][c:12]2[c:13]1[n:14][cH:15][n:16][c:17]2-[c:18]1[cH:19][cH:20][n:21]([cH:22]1)[C:32]1([CH2:31][N:30]([CH2:33]1)[C:28](=[O:29])[O:27][C:24]([CH3:23])([CH3:25])[CH3:26])[CH2:34][C:35]#[N:36]|EP3360878B1_0175
2.3.1|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[C:3]1-[C:2]-[N&H1&+0&D2:1]-1>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[N:7]=[C:8]=[O:9].[N:10]#[C:11][CH:12]1[CH2:13][NH:14]1>Cc1ccccc1>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[O:6])[NH:7][C:8](=[O:9])[N:14]1[CH2:13][CH:12]1[C:11]#[N:10]|US04282212A
9.7.47|[C&H3&D1:6]-[S&H0&+0&D3:5](-[O&H0&-&D1:4])=[O&H0&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:6]-[S&H0&+0&D4:5](=[O&H0&+0&D1:4])(=[O&H0&D1:3])-[C&H2&+0&D2:1]-[c:2]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[CH2:10]Cl)[OH:11].CS([O-])=O.[CH3:12][S:13]([O-:14])=[O:15].[Mg+2]>CCO>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[CH2:10][S:13]([CH3:12])(=[O:14])=[O:15])[OH:11]|US10611747B2_0385
1.2.17|[C:8]-[C&H1&+0&D2:7]=[C&H0&+0&D3:6](-[C:5])-[C:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:8]-[C&H2&+0&D2:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|Cl.Cl.[CH3:1][c:2]1[n:3][n:4]([c:5]2[n:6][cH:7][n:8][c:9]([c:10]12)[NH2:11])[CH:12]([CH3:13])[c:14]1[cH:15][c:16]([c:17]([c:18]([c:19]1[O:20][CH3:21])[CH:22]1[CH2:23][NH:24][CH2:25]1)[CH3:26])[Cl:27].[N:28]#[C:29][CH:30]=[C:31]1[CH2:32][CH2:33][CH2:34]1>CC#N.C1CCN=C2CCCCCN12>[CH3:21][O:20][c:19]1[c:14]([cH:15][c:16]([c:17]([c:18]1[CH:22]1[CH2:23][N:24]([CH2:25]1)[C:31]1([CH2:34][CH2:33][CH2:32]1)[CH2:30][C:29]#[N:28])[CH3:26])[Cl:27])[CH:12]([CH3:13])[n:4]1[n:3][c:2]([c:10]2[c:9]([n:8][cH:7][n:6][c:5]21)[NH2:11])[CH3:1]|US20200071289A1_0472
4.1.5|[C&H3&D1:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:5]-[C:4])=O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[C&H0&+0&D3:6](=[N&H0&+0&D2:5]-[C:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[CH2:9][CH2:10][NH:11][C:12]([CH3:13])=O>O.Cc1ccccc1.O=P(Cl)(Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[C:12](=[N:11][CH2:10][CH2:9][c:7]2[cH:8]1)[CH3:13]|US20070299067A1_0268
9.7.30|[C&H3&D1:6]-[S&H0&+0&D3:5](-[O&H0&-&D1:4])=[O&H0&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[S&H0&+0&D4:5](=[O&H0&+0&D1:4])(=[O&H0&D1:3])-[C&H2&+0&D2:1]-[c:2]|[Na+].[CH3:1][S:2]([O-:3])=[O:4].[OH:5][B:6]([OH:7])[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[CH2:14]Br>Cl.CN(C)C=O>[CH3:1][S:2](=[O:4])(=[O:3])[CH2:14][c:13]1[cH:12][cH:11][cH:10][cH:9][c:8]1[B:6]([OH:5])[OH:7]|US20130029962A1_1104
1.9.10|[C:7]-[C&H1&+0&D2:6]=[O&H0&+0&D1:5].[O&H0&D1:4]=[P&H1&+0&D3:3](-[O:2])-[O:1]>>[C:7]-[C&H1&+0&D3:6](-[O&H1&+0&D1:5])-[P&H0&+0&D4:3](=[O&H0&D1:4])(-[O:2])-[O:1]|[CH3:1][CH2:2][CH2:3][CH2:4][O:5][C:6](=[O:7])[CH:8]=[O:9].[CH3:10][O:11][PH:12](=[O:13])[O:14][CH3:15]>>[CH3:10][O:11][P:12](=[O:13])([O:14][CH3:15])[CH:8]([OH:9])[C:6](=[O:7])[O:5][CH2:4][CH2:3][CH2:2][CH3:1]|US05847186A
3.11.1|[C&H3&+0&D1:6]-[C:5].[C&H3&D1:4]-[C&H0&+0&D3:3](-[C&H3&D1:2])=[O&H0&+0&D1:1]>>[C&H2&+0&D2:6](-[C:5])-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C&H3&D1:2])-[O&H1&+0&D1:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([c:7]([c:8]([cH:9]1)[C:10]([CH3:11])([CH3:12])[CH3:13])[OH:14])[C:15]([CH3:16])([CH3:17])[CH3:18].[CH3:19][C:20]([CH3:21])=[O:22]>C[Si](C)(C)OS(=O)(=O)C(F)(F)F.CC(C)N(CC)C(C)C.ClCCl>[CH3:11][C:10]([CH3:12])([CH3:13])[c:8]1[cH:9][c:4]([cH:5][c:6]([c:7]1[OH:14])[C:15]([CH3:16])([CH3:17])[CH3:18])[C:2](=[O:3])[CH2:1][C:20]([CH3:19])([CH3:21])[OH:22]|EP3042900B1_0515
3.11.39|[C&H1&+0&D1:6]#[C&H1&D1:5].[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H0&+0&D2:6](#[C&H1&D1:5])-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[O&H1&+0&D1:1]|[Br-].[Br-].[CH:1]#[CH:2].[CH3:3][CH2:4][CH2:5][CH2:6][C:7]([CH3:8])([CH3:9])[C:10]([CH3:11])=[O:12].[Mg+2]>CCCCC(C)(C)C=O.C[Mg]Br>[CH:2]#[C:1][C:10]([CH3:11])([OH:12])[C:7]([CH3:8])([CH3:9])[CH2:6][CH2:5][CH2:4][CH3:3]|US20150307439A1_0088
1.2.17|[C:8]-[C&H0&+0&D3:7](-[C:6])=[C&H1&+0&D2:5]-[C:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:8]-[C&H0&+0&D4:7](-[C:6])(-[C&H2&+0&D2:5]-[C:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:12][CH2:13]1)=[CH:14][C:15]#[N:16].[CH3:17][C:18]1([O:19][B:20]([O:21][C:22]1([CH3:23])[CH3:24])[c:25]1[cH:26][n:27][nH:28][cH:29]1)[CH3:30]>C1CN2CCCCCC2=NC1.CC#N>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:13][CH2:12][C:11]([CH2:10][CH2:9]1)([CH2:14][C:15]#[N:16])[n:28]1[cH:29][c:25]([cH:26][n:27]1)[B:20]1[O:19][C:18]([C:22]([O:21]1)([CH3:23])[CH3:24])([CH3:17])[CH3:30]|EP3360878B1_0257
1.9.10|[O&H0&+0&D1:7]=[C&H1&+0&D2:6]-[c:5].[O&H0&D1:4]=[P&H1&+0&D3:3](-[O:2])-[O:1]>>[O&H1&+0&D1:7]-[C&H1&+0&D3:6](-[c:5])-[P&H0&+0&D4:3](=[O&H0&D1:4])(-[O:2])-[O:1]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[Cl:9].[CH3:10][CH2:11][O:12][PH:13](=[O:14])[O:15][CH2:16][CH3:17]>CCN(CC)CC>[CH3:10][CH2:11][O:12][P:13](=[O:14])([O:15][CH2:16][CH3:17])[CH:2]([OH:1])[c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[Cl:9]|US05847186A
4.1.46|[C:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-N)-N>>[C:7]-[n&H0&+0&D3:6]1:[c:5]:[c:4]:[n&H1&+0&D2:3]:[c&H0&+0&D3:1]:1=[O&H0&D1:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[NH:12][c:13]1[cH:14][cH:15][c:16]([cH:17][c:18]1[NH2:19])[C:20]([F:21])([F:22])[F:23].N[C:24](N)=[O:25]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[n:12]1[c:13]2[cH:14][cH:15][c:16]([cH:17][c:18]2[nH:19][c:24]1=[O:25])[C:20]([F:21])([F:22])[F:23]|EP2078016B1_0178
3.7.2|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#12]-Br>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[C:9]([CH3:10])([CH3:11])[CH2:12][C:13](=[O:14])[CH2:15][n:16]1[cH:17][cH:18][c:19]([c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]21)=[O:26])[F:27].Br[Mg][CH:28]1[CH2:29][CH2:30]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[C:9]([CH3:10])([CH3:11])[CH2:12][C:13]([OH:14])([CH2:15][n:16]1[cH:17][cH:18][c:19]([c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]21)=[O:26])[CH:28]1[CH2:29][CH2:30]1)[F:27]|US08013008B2_0478
3.11.33|[C:8]-[C&H0&+0&D3:7](=[C&H1&+0&D2:6]-[c:5])-[C:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:8]-[C&H1&+0&D3:7]1-[C&H1&+0&D3:6](-[c:5])-[c&H0&+0&D3:2](:[c:1]):[c:3]-[C:4]-1|[CH3:1][CH2:2][C:3](=[CH:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[C:11](=[O:12])[c:13]1[cH:14][cH:15][c:16]([c:17]([c:18]1[Cl:19])[Cl:20])[O:21][CH3:22]>O=C(O)C(F)(F)F>[CH3:22][O:21][c:16]1[cH:15][c:14]2[c:13]([C:11]([CH:3]([CH:4]2[c:5]2[cH:6][cH:7][cH:8][cH:9][cH:10]2)[CH2:2][CH3:1])=[O:12])[c:18]([c:17]1[Cl:20])[Cl:19]|US08765746B2_0824
4.2.20|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C:5])=O.[O&H1&+0&D1:4]-[C:3]-[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6]1(-[C:5])-[O&H0&+0&D2:4]-[C:3]-[C:2]-[O&H0&+0&D2:1]-1|[CH3:1][C:2]([OH:3])([CH2:4][OH:5])[CH2:6][O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH3:15][CH2:16][O:17][C:18](=[O:19])[C:20]([CH3:21])=O>c1ccccc1.O.Cl>[CH3:15][CH2:16][O:17][C:18](=[O:19])[C:20]1([O:3][C:2]([CH2:4][O:5]1)([CH3:1])[CH2:6][O:7][CH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[CH3:21]|US20120308486A1_0353
3.7.2|[O&H0&+0&D1:7]=[C&H0&+0&D3:6](-[c:5])-[c:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#12]-Br>>[O&H1&+0&D1:7]-[C&H0&+0&D4:6](-[c:5])(-[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[O:1]=[C:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[CH2:9][CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]12.Br[Mg][CH:17]1[CH2:18][CH2:19]1>[NH4+].[Cl-].Cl.C1CCOC1>[OH:1][C:2]1([c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[CH2:9][CH2:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21)[CH:17]1[CH2:18][CH2:19]1|US20100280247A1_0006
4.2.20|[C&H3&D1:7]-[C&H0&+0&D3:6](-[c:5])=O.[O&H1&+0&D1:4]-[C:3]-[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6]1(-[O&H0&+0&D2:4]-[C:3]-[C:2]-[O&H0&+0&D2:1]-1)-[c:5]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[NH:9][C:10](=[O:11])[CH2:12][Cl:13])[CH3:14].[CH3:15][CH:16]([OH:17])[CH:18]([CH3:19])[OH:20]>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1>[CH3:15][CH:16]1[O:17][C:2]([O:20][CH:18]1[CH3:19])([CH3:1])[c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[NH:9][C:10](=[O:11])[CH2:12][Cl:13])[CH3:14]|EP0379981A1_0037
4.1.16|[C&H3&D1:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[C:2]-[C&H0&+0&D3:1](-O)=O>>[C&H3&D1:7]-[n&H0&+0&D3:6]1:[c:5]:[c:4]:[n&H0&+0&D2:3]:[c&H0&+0&D3:1]:1-[C:2]|[CH3:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7]1)[n:8][cH:9][c:10]([c:11]2[NH:12][CH3:13])[NH2:14].O=[C:15](O)[C:16]([F:17])([F:18])[F:19].Cl>[NH4+].Cl.[OH-]>[CH3:1][c:2]1[cH:7][cH:6][c:5]2[n:8][cH:9][c:10]3[n:14][c:15]([n:12]([c:11]3[c:4]2[cH:3]1)[CH3:13])[C:16]([F:17])([F:18])[F:19]|US09200001B2_0127
1.7.17|[C&H3&D1:7]-[C&H0&+0&D4:6]1(-[C:5])-[C:4]-[O&H0&+0&D2:3]-1.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H0&+0&D2:1]-[C:2])-[C:4]-[O&H1&+0&D1:3]|[CH3:1][C:2]12[O:3][CH:4]1[CH2:5][CH:6]([CH2:7][CH:8]2[OH:9])[C:10]([CH3:11])([CH3:12])[OH:13]>>[CH3:1][C:2]12[O:13][C:10]([CH:6]([CH2:5][CH:4]1[OH:3])[CH2:7][CH:8]2[OH:9])([CH3:11])[CH3:12]|EP3019196B1_1932
4.1.16|[C&H3&D1:7]-[C&H0&+0&D3:6](-O)=O.[C:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D3:4]:1-[C:5]|[CH3:1][C:2](=O)O.[CH3:3][CH2:4][NH:5][c:6]1[n:7][c:8]([c:9]([c:10]([c:11]1[NH2:12])[O:13][CH2:14][CH3:15])[C:16](=[O:17])[O:18][CH2:19][CH3:20])[CH3:21]>>[CH3:20][CH2:19][O:18][C:16](=[O:17])[c:9]1[c:8]([n:7][c:6]2[c:11]([n:12][c:2]([n:5]2[CH2:4][CH3:3])[CH3:1])[c:10]1[O:13][CH2:14][CH3:15])[CH3:21]|US20040157866A1_1376
1.9.20|[C:6]-[O&H1&+0&D1:5].[Cl&H0&D1:4]-[P&H0&+0&D4:3](-[Cl&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:6]-[O&H0&+0&D2:5]-[P&H0&+0&D4:3](-[Cl&H0&D1:4])(-[Cl&H0&D1:2])=[O&H0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][OH:5].[O:6]=[P:7]([Cl:8])([Cl:9])Cl>ClC(Cl)(Cl)Cl>[CH3:1][CH2:2][CH2:3][CH2:4][O:5][P:7](=[O:6])([Cl:8])[Cl:9]|US20200369695A1_0275
3.7.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#12]-Br>>[C:7]-[C&H0&+0&D4:6](-[O&H1&+0&D1:5])(-[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[C:8](=[O:9])[CH:10]1[CH2:11][CH2:12]1)-[c:13]1[cH:14][cH:15][cH:16][c:17]([cH:18]1)[Cl:19].Br[Mg][CH:20]1[CH2:21][CH2:22]1>>[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[C:8]([OH:9])([CH:10]1[CH2:11][CH2:12]1)[CH:20]1[CH2:21][CH2:22]1)-[c:13]1[cH:18][c:17]([cH:16][cH:15][cH:14]1)[Cl:19]|US09284277B2_0273
5.3.4|[C&H3&D1:6]-[#14&H0&+0&D4:5](-[C&H3&D1:4])(-[C&H3&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[#14&H0&+0&D4:5](-[C&H3&D1:4])(-[C&H3&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH:3]([CH3:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([c:10]1[OH:11])[CH:12]([CH3:13])[CH2:14][CH3:15].[CH3:16][Si:17]([CH3:18])([CH3:19])Cl>C[Si](C)(C)NCCN[Si](C)(C)C.Oc1ccccc1.ClCCl>[CH3:1][CH2:2][CH:3]([CH3:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([c:10]1[O:11][Si:17]([CH3:16])([CH3:18])[CH3:19])[CH:12]([CH3:13])[CH2:14][CH3:15]|US04477445A
1.9.20|[Cl&H0&D1:6]-[P&H0&+0&D4:5](-[Cl&H0&D1:4])(=[O&H0&D1:3])-Cl.[O&H1&+0&D1:2]-[c:1]>>[Cl&H0&D1:6]-[P&H0&+0&D4:5](-[Cl&H0&D1:4])(=[O&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[OH:11].[O:12]=[P:13]([Cl:14])([Cl:15])Cl>c1ccncc1>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][P:13](=[O:12])([Cl:14])[Cl:15]|US20150266908A1_0149
5.3.4|[C&H3&D1:6]-[#14&H0&+0&D4:5](-[C&H3&D1:4])(-[C&H3&D1:3])-Cl.[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:6]-[#14&H0&+0&D4:5](-[C&H3&D1:4])(-[C&H3&D1:3])-[O&H0&+0&D2:1]-[C:2]|[CH3:1][C:2]1[CH2:3][S:4][C@@H:5]2[CH:6]([C:7]([N:8]2[C:9]=1[C:10](=[O:11])[OH:12])=[O:13])[NH:14][C:15](=[O:16])[CH:17]([Cl:18])[Cl:19].[CH3:20][Si:21]([CH3:22])([CH3:23])Cl>CCN(CC)CC.ClC(Cl)Cl>[CH3:1][C:2]1[CH2:3][S:4][C@@H:5]2[CH:6]([C:7]([N:8]2[C:9]=1[C:10](=[O:11])[O:12][Si:21]([CH3:20])([CH3:22])[CH3:23])=[O:13])[NH:14][C:15](=[O:16])[CH:17]([Cl:19])[Cl:18]|EP3210969A1_0379
1.2.18|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H1&+0&D3:5](-[C:4])-[C:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:2]-[c:1])=[C&H0&+0&D3:5](-[C:4])-[C:3]|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[CH3:8])-[c:9]1[n:10][cH:11][cH:12][cH:13][c:14]1[NH2:15])[CH3:16].[CH3:17][C:18](=O)[CH:19]1[CH2:20][CH2:21][O:22][C:23]1=[O:24]>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:17][C:18]([NH:15][c:14]1[cH:13][cH:12][cH:11][n:10][c:9]1-[c:5]1[c:6]([cH:7][c:2]([cH:3][c:4]1[CH3:16])[CH3:1])[CH3:8])=[C:19]1[CH2:20][CH2:21][O:22][C:23]1=[O:24]|US06927221B2_0459
2.6.4|[C:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[c&H0&+0&D3:4](:[c:3]):[c:2].[O&H1&+0&D1:1]-O>>[C:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[O&H0&+0&D2:1]-[c&H0&+0&D3:4](:[c:3]):[c:2]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[cH:11]1)[C:12](=[O:13])[CH:14]([CH3:15])[CH3:16].[OH:17]O>O=CO>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[cH:11]1)[O:17][C:12](=[O:13])[CH:14]([CH3:15])[CH3:16]|US10065972B2_4604
1.2.18|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:7]-[C&H0&+0&D3:6](-[C:5])=[C&H0&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][CH:2]1[C:3]([CH2:4][CH2:5][C:6]1=[O:7])=O.[NH2:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[C:15]1[CH2:16][CH2:17][C:18]([NH:19][N:20]=1)=[O:21]>O.Cc1ccccc1>[CH3:1][C:2]1[C:6]([CH2:5][CH2:4][C:3]=1[NH:8][c:9]1[cH:14][cH:13][c:12]([cH:11][cH:10]1)[C:15]1[CH2:16][CH2:17][C:18]([NH:19][N:20]=1)=[O:21])=[O:7]|US10351511B2_0238
3.11.16|[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)I.[F:11][C:12]([F:13])([I:14])[C:15]([F:16])([F:17])[C:18]([F:19])([F:20])I>FC(F)(F)C(I)(I)C(F)(F)F.CC([O-])=O.CS(C)=O.[Cu]>[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:18]([F:19])([F:20])[C:15]([F:16])([F:17])[C:12]([F:11])([F:13])[I:14]|US20200163948A1_1248
4.1.45|[C&H3&D1:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[C:2]-[C&H0&+0&D3:1](-Cl)=O>>[C&H3&D1:7]-[n&H0&+0&D3:6]1:[c:5]:[c:4]:[n&H0&+0&D2:3]:[c&H0&+0&D3:1]:1-[C:2]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][n:6][cH:7][c:8]1[NH2:9].O=[C:10](Cl)[CH:11]1[CH2:12][CH2:13]1>CCN(CC)CC.ClCCl>[CH3:1][n:2]1[c:3]2[cH:4][cH:5][n:6][cH:7][c:8]2[n:9][c:10]1[CH:11]1[CH2:12][CH2:13]1|EP3153509B1_0018
7.6.1|[C:8]-[n&H0&+0&D3:7]1:[c:6]:[c:5]:[c&H0&+0&D3:4](-[C:3]):[c&H0&+0&D3:2]:1-[C:1]>>[C:8]-[N&H0&+0&D3:7]1-[c:6]:[c:5]-[C&H1&+0&D3:4](-[C:3])-[C&H1&+0&D3:2]-1-[C:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[c:9]([c:10]([n:11]2[C:12](=[O:13])[O:14][CH2:15][CH3:16])[C:17]([CH3:18])=[O:19])[CH2:20][CH2:21][NH:22][C:23]([CH3:24])=[O:25]>CCO.[H][H].[OH-].[OH-].[Pd+2]>[CH3:24][C:23](=[O:25])[NH:22][CH2:21][CH2:20][CH:9]1[c:7]2[cH:8][c:3]([cH:4][cH:5][c:6]2[N:11]([CH:10]1[C:17]([CH3:18])=[O:19])[C:12](=[O:13])[O:14][CH2:15][CH3:16])[O:2][CH3:1]|US09063126B2_0807
1.8.4|[O&H0&-&D1:7]-[S&H0&+0&D3:6](=[O&H0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[O&H0&+0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[O-:1][S:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Br:10].[O:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][c:17]([cH:18]1)I>CS(C)=O.CCOC(C)=O.I[Cu]>[O:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][c:17]([cH:18]1)[S:2](=[O:1])(=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Br:10]|US09067949B2_0657
2.3.10|[C:7]-[N&H0&+0&D3:6](-[c:5]:[c:4]-[N&H2&+0&D1:3])-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[C:7]-[n&H0&+0&D3:6]1:[c:5]:[c:4]:[n&H1&+0&D2:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1]|CO[C:1](=[O:2])[N:3]([CH2:4][CH:5]([F:6])[F:7])[c:8]1[c:9]([n:10][c:11]([n:12][c:13]1[NH2:14])-[c:15]1[n:16][n:17]([c:18]2[n:19][cH:20][cH:21][cH:22][c:23]21)[CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][c:30]1[F:31])[NH2:32]>C1CCOC1>[NH2:32][c:9]1[n:10][c:11]([n:12][c:13]2[nH:14][c:1]([n:3]([c:8]12)[CH2:4][CH:5]([F:6])[F:7])=[O:2])-[c:15]1[n:16][n:17]([c:18]2[n:19][cH:20][cH:21][cH:22][c:23]21)[CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][c:30]1[F:31]|EP2188280B1_0120
1.2.6|[C:7]-[C&H0&+0&D3:6](-[c:5])=O.[C:4]-[S&H0&+0&D3:3](-[N&H2&+0&D1:2])=[O&H0&D1:1]>>[C:7]-[C&H0&+0&D3:6](=[N&H0&+0&D2:2]-[S@&H0&+0&D3:3](-[C:4])=[O&H0&D1:1])-[c:5]|[CH3:1][C@H:2]([NH:3][C:4](=[O:5])[O:6][C:7]([CH3:8])([CH3:9])[CH3:10])[C:11](=O)[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[F:18].[CH3:19][C:20]([CH3:21])([CH3:22])[S:23]([NH2:24])=[O:25]>>[CH3:8][C:7]([CH3:9])([CH3:10])[O:6][C:4](=[O:5])[NH:3][C@@H:2]([CH3:1])[C:11](=[N:24][S@:23](=[O:25])[C:20]([CH3:19])([CH3:21])[CH3:22])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[F:18]|US20200317665A1_0356
1.6.2|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C:5]-[O&H0&+0&D2:4]-C)-Br.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[C&H1&+0&D3:6](-[C:5]-[O&H1&+0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|C[O:1][C:2](=[O:3])[CH:4]([CH3:5])Br.[CH3:6][c:7]1[cH:8][nH:9][c:10]([nH:11][c:12]1=[O:13])=[O:14]>CN(C)C=O.O=C(O[K])O[K]>[CH3:6][c:7]1[cH:8][n:9]([c:10]([nH:11][c:12]1=[O:13])=[O:14])[CH:4]([CH3:5])[C:2](=[O:3])[OH:1]|EP3038618B1_0338
4.1.46|[C:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-Cl)-Cl>>[C:7]-[n&H0&+0&D3:6]1:[c:5]:[c:4]:[n&H1&+0&D2:3]:[c&H0&+0&D3:1]:1=[O&H0&D1:2]|Cl.Cl.Cl.[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([c:7]1[NH2:8])[NH:9][CH2:10][CH2:11][CH3:12])[O:13][CH2:14][CH:15]([OH:16])[CH2:17][N:18]1[CH2:19][CH2:20][CH:21]([CH2:22][CH2:23]1)[CH2:24][O:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1.[O:32]=[C:33](Cl)Cl>>[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]2[c:7]1[nH:8][c:33]([n:9]2[CH2:10][CH2:11][CH3:12])=[O:32])[O:13][CH2:14][CH:15]([OH:16])[CH2:17][N:18]1[CH2:19][CH2:20][CH:21]([CH2:22][CH2:23]1)[CH2:24][O:25][c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1|US09890152B2_1169
2.1.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-O.[C:4]-[C&H1&+0&D3:3](-[N&H2&+0&D1:2])-[c:1]>>[C:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:2]-[C@&H1&+0&D3:3](-[C:4])-[c:1])=[O&H0&D1:5]|[CH3:1][C:2]1([S:3][C@@H:4]2[CH2:5][C:6]([N:7]2[C@H:8]1[C:9](=[O:10])[OH:11])=[O:12])[CH2:13][NH:14][C:15](=[O:16])[CH:17]([NH2:18])[c:19]1[cH:20][cH:21][s:22][cH:23]1.[NH2:24][C:25](=[O:26])[NH:27][C@H:28]([CH2:29][c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[OH:36])[C:37](=[O:38])O>>[CH3:1][C:2]1([S:3][C@@H:4]2[CH2:5][C:6]([N:7]2[C@H:8]1[C:9](=[O:10])[OH:11])=[O:12])[CH2:13][NH:14][C:15](=[O:16])[C@H:17]([NH:18][C:37](=[O:38])[C@@H:28]([CH2:29][c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[OH:36])[NH:27][C:25]([NH2:24])=[O:26])[c:19]1[cH:23][s:22][cH:21][cH:20]1|EP3212189B1_0502
1.8.3|[O&H0&-&D1:7]-[S&H0&+0&D3:6](=[O&H0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[O&H0&+0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[O-:1][S:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[O:10]=[C:11]1[c:12]2[cH:13][c:14]3[cH:15][cH:16][cH:17][cH:18][c:19]3[cH:20][c:21]2[C:22]([c:23]2[cH:24][cH:25][c:26]([cH:27][c:28]12)F)=[O:29]>CS(C)=O>[O:29]=[C:22]1[c:21]2[cH:20][c:19]3[cH:18][cH:17][cH:16][cH:15][c:14]3[cH:13][c:12]2[C:11]([c:28]2[cH:27][c:26]([cH:25][cH:24][c:23]12)[S:2](=[O:1])(=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)=[O:10]|US20110312945A1_0421
2.8.5|[C&H3&D1:6]-[C&H0&+0&D3:5](-[O&H0&-&D1:4])=[S&H0&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-I>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH:6]=[CH:7][CH2:8][N:9]2[C:10]([C:11]([C:12]([N:13]12)=[O:14])([CH3:15])[CH2:16][CH2:17]I)=[O:18].[CH3:19][C:20]([O-:21])=[S:22].[K+]>CC(C)=O>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH:6]=[CH:7][CH2:8][N:9]2[C:10]([C:11]([C:12]([N:13]12)=[O:14])([CH3:15])[CH2:16][CH2:17][S:22][C:20]([CH3:19])=[O:21])=[O:18]|EP1648868B1_0116
2.1.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-O.[C:4]-[C&H1&+0&D3:3](-[C:2])-[N&H2&+0&D1:1]>>[C:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:1]-[C@&H1&+0&D3:3](-[C:4])-[C:2])=[O&H0&D1:5]|[CH3:1][C:2](=[O:3])[O:4][c:5]1[cH:6][c:7]2[c:8]([cH:9][c:10]1[O:11][C:12]([CH3:13])=[O:14])[o:15][cH:16][c:17]([c:18]2=[O:19])[C:20](=[O:21])[NH:22][C@@H:23]([C:24](=[O:25])O)[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1.[CH3:32][n:33]1[n:34][n:35][n:36][c:37]1[S:38][CH2:39][C:40]1[CH2:41][S:42][C@@H:43]2[CH:44]([C:45]([N:46]2[C:47]=1[C:48](=[O:49])[OH:50])=[O:51])[NH2:52]>C[Si](C)(C)O/C(C)=N/[Si](C)(C)C.CN(C)c1ccccc1.CCOC(=O)Cl.CN(C)C=O.CC#N.ClCCl>[CH3:13][C:12](=[O:14])[O:11][c:10]1[cH:9][c:8]2[o:15][cH:16][c:17]([c:18]([c:7]2[cH:6][c:5]1[O:4][C:2]([CH3:1])=[O:3])=[O:19])[C:20](=[O:21])[NH:22][C@@H:23]([C:24](=[O:25])[NH:52][C@@H:44]1[C:45]([N:46]2[C@@H:43]1[S:42][CH2:41][C:40](=[C:47]2[C:48](=[O:49])[OH:50])[CH2:39][S:38][c:37]1[n:36][n:35][n:34][n:33]1[CH3:32])=[O:51])[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1|EP0874853B1_0032
2.1.1|[N&H2&+0&D1:7]-[C:6]-[C:5]-[O&H0&+0&D2:4]-C.[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[N&H1&+0&D2:7](-[C:6]-[C:5]-[O&H1&+0&D1:4])-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([n:7]1[CH3:8])=[O:9])-[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][C@H:17]([NH2:18])[C:19](=[O:20])[O:21]C)[C:22]([F:23])([F:24])[F:25].[CH3:26][c:27]1[cH:28][cH:29][cH:30][c:31]([c:32]1[C:33](=[O:34])Cl)[CH:35]([CH3:36])[CH3:37]>>[CH3:8][n:7]1[c:2]([cH:3][c:4]([c:5]([c:6]1=[O:9])-[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][C@H:17]([NH:18][C:33](=[O:34])[c:32]1[c:27]([cH:28][cH:29][cH:30][c:31]1[CH:35]([CH3:36])[CH3:37])[CH3:26])[C:19](=[O:20])[OH:21])[C:22]([F:23])([F:24])[F:25])[CH3:1]|US04670421A
5.5.3|[C:7]-[C&H1&+0&D2:6]=[O&H0&+0&D1:5].[O&H1&+0&D1:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-O>>[C:7]-[C&H1&+0&D3:6]1-[O&H0&+0&D2:5]-[C&H2&+0&D2:1]-[C:2]-[C:3]-[O&H0&+0&D2:4]-1|[CH3:1][O:2][CH2:3][CH:4]=[O:5].O[CH2:6][CH2:7][CH2:8][OH:9]>C1CCCCC1.O>[CH3:1][O:2][CH2:3][CH:4]1[O:5][CH2:6][CH2:7][CH2:8][O:9]1|US20110112103A1_1133
4.1.22|[C:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C:2]-[C&H2&+0&D2:1]-Cl)-Cl>>[C:7]-[N&H0&+0&D3:6]1-[C&H2&+0&D2:1]-[C:2]-[C:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|[CH3:1][CH2:2][C@H:3]([NH2:4])[C:5]([NH2:6])=[O:7].[O:8]=[C:9](Cl)[CH2:10][CH2:11][CH2:12]Cl.Cl>CCCC[N+](CCCC)(CCCC)CCCC.O=S(=O)(O[Na])O[Na].ClCCl.O[K].[Br-]>[CH3:1][CH2:2][C@@H:3]([C:5]([NH2:6])=[O:7])[N:4]1[CH2:12][CH2:11][CH2:10][C:9]1=[O:8]|US20200299273A1_0433
2.1.2|[C:7]-[C&H1&+0&D3:6](-[N:5])-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C:7]-[C@&H1&+0&D3:6](-[N:5])-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]([CH2:10][NH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[NH2:18])[C:19](=[O:20])O>CCN=C=NCCCN(C)C.CCOC(C)=O.CN(C)C=O.Cl>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@H:9]1[CH2:10][NH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[NH:18][C:19]1=[O:20]|US09499519B2_1492
3.11.16|[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([F:7])([F:8])Br.[Cl:9][c:10]1[cH:11][cH:12][c:13]([n:14][cH:15]1)I>[NH4+].[Cl-].CS(C)=O.[Cu]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([F:7])([F:8])[c:13]1[cH:12][cH:11][c:10]([cH:15][n:14]1)[Cl:9]|US20200163948A1_1218
4.1.76|[C:7]-[C&H1&+0&D2:6]=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH2:11][CH:12]([CH2:13]1)[CH:14]=O.[NH2:15][NH:16][c:17]1[cH:18][cH:19][c:20]([cH:21][n:22]1)-[c:23]1[c:24]([n:25][c:26]2[o:27][cH:28][cH:29][n:30]21)-[c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[F:37]>>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:13][CH:12]([CH2:11][CH2:10][CH2:9]1)[c:14]1[n:15][n:16][c:17]2[cH:18][cH:19][c:20]([cH:21][n:22]12)-[c:23]1[c:24]([n:25][c:26]2[o:27][cH:28][cH:29][n:30]21)-[c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[F:37]|US09670208B2_0372
3.11.16|[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-Br.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][C:10]([F:11])([F:12])[C:13]([F:14])([F:15])Br)[N+:16]([O-:17])=[O:18].[Cl:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)I>Cl.CS(C)=O.[Cu]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][C:10]([F:11])([F:12])[C:13]([F:14])([F:15])[c:23]1[cH:24][cH:25][c:20]([cH:21][cH:22]1)[Cl:19])[N+:16]([O-:17])=[O:18]|US20200163948A1_1159
4.1.76|[C:7]-[C&H1&+0&D2:6]=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c:3]:[n&H0&+0&D2:2]:[n:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[n:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[cH:12][n:13][c:14]([n:15][n:16]1)[NH:17][NH2:18].O=[CH:19][C:20]1([CH2:21][CH2:22]1)[c:23]1[cH:24][cH:25][c:26]2[n:27][cH:28][s:29][c:30]2[cH:31]1>CC(=O)O.CC(=O)O[I](OC(C)=O)c1ccccc1.CCO>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[cH:12][n:13][c:14]2[n:17][n:18][c:19]([n:15]2[n:16]1)[C:20]1([CH2:21][CH2:22]1)[c:23]1[cH:24][cH:25][c:26]2[n:27][cH:28][s:29][c:30]2[cH:31]1|US08188083B2_0901
2.1.2|[C:7]-[C&H1&+0&D3:6](-[N&H2&+0&D1:5])-[c:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:7]-[C@&H1&+0&D3:6](-[N&H1&+0&D2:5]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1])-[c:4]|Cl.[CH3:1][O:2][c:3]1[c:4]([cH:5][c:6]([cH:7][c:8]1[Cl:9])-[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[C:16]([F:17])([F:18])[F:19])[C:20](=[O:21])O.[CH3:22][c:23]1[n:24][o:25][c:26]([n:27]1)[CH:28]([NH2:29])[CH2:30][c:31]1[cH:32][cH:33][cH:34][c:35]([cH:36]1)-[c:37]1[cH:38][cH:39][c:40]([c:41]([cH:42]1)[Cl:43])[F:44]>>[CH3:1][O:2][c:3]1[c:8]([cH:7][c:6]([cH:5][c:4]1[C:20](=[O:21])[NH:29][C@H:28]([CH2:30][c:31]1[cH:32][cH:33][cH:34][c:35]([cH:36]1)-[c:37]1[cH:38][cH:39][c:40]([c:41]([cH:42]1)[Cl:43])[F:44])[c:26]1[n:27][c:23]([n:24][o:25]1)[CH3:22])-[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[C:16]([F:17])([F:18])[F:19])[Cl:9]|EP3431464A2_0430
2.8.5|[C&H3&D1:6]-[C&H0&+0&D3:5](-[O&H0&-&D1:4])=[S&H0&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-O>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|O[CH2:1][CH2:2][O:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)-[c:10]1[cH:11][cH:12][s:13][cH:14]1.[CH3:15][C:16]([O-:17])=[S:18].[K+]>CS(=O)(=O)OCCc1cccc(c1)-c1ccsc1.CCN(CC)CC.CCOC(C)=O.CS(=O)(=O)Cl.CN(C)C=O.O>[CH3:15][C:16](=[O:17])[S:18][CH2:1][CH2:2][O:3][c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)-[c:10]1[cH:11][cH:12][s:13][cH:14]1|EP2722326A1_0175
3.11.16|[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[F:1][C:2]([F:3])([F:4])[C:5]([F:6])([F:7])[C:8]([F:9])([F:10])[C:11]([F:12])([F:13])[C:14]([F:15])([F:16])[C:17]([F:18])([F:19])[C:20]([F:21])([F:22])[C:23]([F:24])([F:25])[C:26]([F:27])([F:28])[C:29]([F:30])([F:31])I.[CH3:32][c:33]1[cH:34][cH:35][c:36]([c:37]([cH:38]1)Br)[CH3:39]>CS(C)=O>[CH3:32][c:33]1[cH:34][cH:35][c:36]([c:37]([cH:38]1)[C:29]([F:30])([F:31])[C:26]([F:27])([F:28])[C:23]([F:24])([F:25])[C:20]([F:21])([F:22])[C:17]([F:18])([F:19])[C:14]([F:15])([F:16])[C:11]([F:12])([F:13])[C:8]([F:10])([F:9])[C:5]([F:6])([F:7])[C:2]([F:1])([F:3])[F:4])[CH3:39]|US10647661B2_2495
2.2.3|[O&H0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-Cl.[C:3]1-[C:2]-[N&H1&+0&D2:1]-1>>[O&H0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-[N&H0&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])Cl.[CH3:11][C:12]1([CH2:13][NH:14]1)[CH3:15]>CCOCC.c1ccncc1>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[N:14]1[CH2:13][C:12]1([CH3:11])[CH3:15]|EP2663561B1_0160
2.1.2|[C:7]-[C@&H1&+0&D3:6](-[N&H2&+0&D1:5])-[c:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:7]-[C&H1&+0&D3:6](-[N&H1&+0&D2:5]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1])-[c:4]|[CH3:1][CH:2]([CH3:3])[CH2:4][C@H:5]([NH2:6])[c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1.[CH3:19][CH2:20][O:21][c:22]1[cH:23][c:24]([cH:25][cH:26][c:27]1[C:28](=[O:29])[O:30][CH2:31][CH3:32])[CH2:33][C:34](=[O:35])O>>[CH3:32][CH2:31][O:30][C:28](=[O:29])[c:27]1[cH:26][cH:25][c:24]([cH:23][c:22]1[O:21][CH2:20][CH3:19])[CH2:33][C:34](=[O:35])[NH:6][CH:5]([CH2:4][CH:2]([CH3:1])[CH3:3])[c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1|US20200299238A1_0675
4.1.45|[C&H3&D1:7]-[C&H0&+0&D3:6](=N)-O-C.[C:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D3:4]:1-[C:5]|Cl.[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1[NH2:12])-[c:13]1[n:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[o:21]1.[CH3:22][C:23](=N)OC>[Na+].CO.[O-]C(=O)O>[CH3:22][c:23]1[n:12][c:11]2[cH:10][c:9]([cH:8][cH:7][c:6]2[n:5]1[CH2:4][CH2:3][CH2:2][CH3:1])-[c:13]1[n:14][c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[o:21]1|US09890152B2_1518
4.1.45|[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=S.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:7]-[N&H1&+0&D2:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1|[NH2:1][c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[NH2:8])[Cl:9])[Cl:10].[CH3:11][C:12]([CH3:13])([CH3:14])[N:15]=[C:16]=S>C(=NCCN1CCOCC1)=NC1CCCCC1.Cc1ccc(cc1)S([O-])(=O)=O.c1ccncc1>[CH3:11][C:12]([CH3:13])([CH3:14])[NH:15][c:16]1[n:8][c:7]2[cH:6][c:5]([c:4]([cH:3][c:2]2[nH:1]1)[Cl:10])[Cl:9]|EP3419973B1_0421
3.10.1|[O&H0&D1:7]=[C&H0&+0&D3:6](-[C:5]-[O&H0&+0&D2:4]-C)-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&D1:7]=[C&H0&+0&D3:6](-[C:5]-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|C[O:1][C:2](=[O:3])[C:4](=[O:5])Cl.[CH3:6][O:7][c:8]1[cH:9][n:10][c:11]([c:12]2[nH:13][cH:14][cH:15][c:16]12)-[c:17]1[cH:18][n:19][cH:20][cH:21][n:22]1>CO.C[N+]([O-])=O.O=C(O[K])O[K].ClCCl.Cl[Al](Cl)Cl>[CH3:6][O:7][c:8]1[cH:9][n:10][c:11]([c:12]2[nH:13][cH:14][c:15]([c:16]12)[C:4](=[O:5])[C:2](=[O:3])[OH:1])-[c:17]1[cH:18][n:19][cH:20][cH:21][n:22]1|US20190241514A1_0379
8.8.18|[C:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[c:4]:[c:3]-[C&H2&+0&D2:2]-[C&H2&+0&D2:1]-1>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c:4]:[c:3]:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[CH:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:10][c:11]([n:12]2-[c:13]2[cH:14][cH:15][c:16]([c:17]([cH:18]2)[C:19](=[O:20])[OH:21])[OH:22])-[c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[CH2:29]1>Cc1ccccc1C.[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10][c:11]([n:12]2-[c:13]2[cH:14][cH:15][c:16]([c:17]([cH:18]2)[C:19](=[O:20])[OH:21])[OH:22])-[c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[cH:29]1|US20070275962A1_1297
2.1.2|[C:7]-[N&H2&+0&D1:6].[C:5]-[C&H1&+0&D3:4](-[C:3])-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C@@&H1&+0&D3:4](-[C:5])-[C:3]|[CH3:1][N:2]1[CH2:3][CH:4]([CH2:5][C@@H:6]2[c:7]3[cH:8][cH:9][cH:10][c:11]4[c:12]3[c:13]([cH:14][n:15]4[CH3:16])[CH2:17][C@H:18]21)[C:19](=[O:20])O.[NH2:21][CH2:22][c:23]1[cH:24][n:25][cH:26][cH:27][cH:28]1>[NH4+].CN(C)C=O.O=P(Cl)(Cl)Cl.[OH-]>[CH3:16][n:15]1[cH:14][c:13]2[CH2:17][C@@H:18]3[C@H:6]([CH2:5][C@H:4]([CH2:3][N:2]3[CH3:1])[C:19](=[O:20])[NH:21][CH2:22][c:23]3[cH:28][cH:27][cH:26][n:25][cH:24]3)[c:7]3[cH:8][cH:9][cH:10][c:11]1[c:12]32|US08716281B2_0309
2.8.5|[C&H3&D1:6]-[C&H0&+0&D3:5](-[O&H0&-&D1:4])=[S&H0&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[Na+].[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([cH:8][c:9]2[n:10][c:11]([n:12]([c:13]([c:14]2[c:15]1[CH3:16])=[O:17])-[c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[Cl:24])[CH2:25]Br)[CH3:26].[CH3:27][C:28]([O-:29])=[S:30]>O.O.O.CN(C)C=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([cH:8][c:9]2[n:10][c:11]([n:12]([c:13]([c:14]2[c:15]1[CH3:16])=[O:17])-[c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[Cl:24])[CH2:25][S:30][C:28]([CH3:27])=[O:29])[CH3:26]|US20180118708A1_0647
3.11.76|[C:8]-[C&H1&+0&D3:7](-[C:6])-[C:5].[N&+:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[c:1]>>[C:8]-[C&H0&+0&D4:7](-[C:6])(-[C:5])-[C&H1&+0&D3:2](-[c:1])-[C&H2&+0&D2:3]-[N&+:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:7][CH2:8][N:9]([CH2:10][CH2:11]1)[C@@H:12]1[CH2:13][CH2:14][CH2:15][CH2:16][C@@H:17]1[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[F:24].[CH3:25][O:26][c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)[CH:33]=[CH:34][N+:35]([O-:36])=[O:37]>>[CH3:25][O:26][c:27]1[cH:32][cH:31][c:30]([cH:29][cH:28]1)[CH:33]([CH2:34][N+:35]([O-:36])=[O:37])[C:6]1([CH2:7][CH2:8][N:9]([CH2:10][CH2:11]1)[C@@H:12]1[CH2:13][CH2:14][CH2:15][CH2:16][C@@H:17]1[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[F:24])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20180141962A1_0442
4.1.24|[C:6]-[C&H0&+0&D2:5]#[N&H0&+0&D1:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:1|[Na+].[N-:1]=[N+:2]=[N-:3].[N:4]#[C:5][CH2:6][O:7][c:8]1[cH:9][cH:10][c:11]([c:12]([c:13]1[Cl:14])[Cl:15])[C:16](=[O:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>Cl.Cl[Al](Cl)Cl.C1CCOC1>[O:17]=[C:16]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:11]1[cH:10][cH:9][c:8]([c:13]([c:12]1[Cl:15])[Cl:14])[O:7][CH2:6][c:5]1[n:4][n:3][n:2][nH:1]1|US20190038588A1_0169
2.1.24|[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[c:2].[N&H0&+0&D2:1](-[#11])=[N&+]=[N&-]>>[C:6]-[C&H2&+0&D2:5]-[N&H1&+0&D2:1]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[c:2]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[C:7]([CH2:8][CH2:9][c:10]12)=[O:11].[N-]=[N+]=[N:12][Na]>O.O=C(O)C(Cl)(Cl)Cl>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[C:7]([NH:12][CH2:8][CH2:9][c:10]12)=[O:11]|US20200323869A1_0373
2.1.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-O.[C:4]-[C&H1&+0&D3:3](-[C:2])-[N&H2&+0&D1:1]>>[C:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:1]-[C@@&H1&+0&D3:3](-[C:4])-[C:2])=[O&H0&D1:5]|Cl.[CH3:1][O:2][C:3](=[O:4])[CH:5]([NH2:6])[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[O:14]=[C:15]([NH:16][C@H:17]([C:18](=[O:19])O)[CH:20]([CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[C:28](=[O:29])[OH:30])[O:31][CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1>CN(C)C=O>[CH3:1][O:2][C:3](=[O:4])[C@H:5]([CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[NH:6][C:18](=[O:19])[C@@H:17]([NH:16][C:15](=[O:14])[O:31][CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1)[CH:20]([CH2:21][c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1)[C:28](=[O:29])[OH:30]|US20160122331A1_1467
7.6.1|[N:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c:3]:[n:2]:[n&H0&+0&D2:1]:1>>[N:7]-[C&H0&+0&D3:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[c:3]:[n:2]-[N&H0&+0&D2:1]=1|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[c:14]1[cH:15][cH:16][c:17]2[n:18][n:19][c:20]([n:21]2[n:22]1)[C:23]([F:24])([F:25])[F:26]>CO.[Pd]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[C:14]1[CH2:15][CH2:16][c:17]2[n:18][n:19][c:20]([n:21]2[N:22]=1)[C:23]([F:24])([F:25])[F:26]|US08258140B2_0757
2.1.1|[C:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-Cl.[C:4]-[C&H1&+0&D3:3](-[C:2])-[N&H2&+0&D1:1]>>[C:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:1]-[C@&H1&+0&D3:3](-[C:4])-[C:2])=[O&H0&D1:5]|[CH3:1][CH2:2][CH:3]([NH2:4])[CH2:5][OH:6].[O:7]=[C:8](Cl)[C:9]1([CH2:10][CH2:11]1)[Br:12]>O=C(N[C@@H](CO)c1ccccc1)C1(CC1)Br>[CH3:1][CH2:2][C@H:3]([CH2:5][OH:6])[NH:4][C:8](=[O:7])[C:9]1([CH2:10][CH2:11]1)[Br:12]|EP0062876B1_0042
1.8.1|[O&H0&-&D1:7]-[S&H0&+0&D3:6](=[O&H0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[O&H0&+0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[O-:1][S:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Br:10].[O:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1Br>O.CS(C)=O.CN(C)CCN>[O:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[S:2](=[O:3])(=[O:1])[c:4]1[cH:9][cH:8][c:7]([cH:6][cH:5]1)[Br:10]|US20080221127A1_0547
7.9.12|[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[n&H0&+0&D2:4]:[c:3]:[c:2]:[c&H1&+0&D2:1]:1>>[C:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[C&H2&+0&D2:1]-1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][C@H:8]([NH:9][C:10](=[O:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[CH2:18][N:19]([CH:20]=[O:21])[CH2:22][c:23]1[cH:24][n:25][c:26]2[n:27][c:28]([n:29][c:30]([c:31]2[cH:32]1)[OH:33])[NH:34][C:35](=[O:36])[C:37]([CH3:38])([CH3:39])[CH3:40])[C:41](=[O:42])[O:43][CH2:44][CH3:45]>CC(=O)O.[H][H].[O-2].[Pt+2]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][C@H:8]([NH:9][C:10](=[O:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[CH2:18][N:19]([CH:20]=[O:21])[CH2:22][CH:23]1[CH2:32][c:31]2[c:30]([n:29][c:28]([n:27][c:26]2[NH:25][CH2:24]1)[NH:34][C:35](=[O:36])[C:37]([CH3:38])([CH3:39])[CH3:40])[OH:33])[C:41](=[O:42])[O:43][CH2:44][CH3:45]|US10221142B2_0377
1.8.6|[C&H3&+0&D1:6]-I.[C&H3&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C&H3&+0&D1:6]-[S&H0&+0&D2:1]-[C&H0&+0&D3:3](-[N:2])=[N&H0&+0&D2:4]-[C&H3&D1:5]|[CH3:1][N:2]([CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10])[C:11](=[S:12])[NH:13][CH3:14].[CH3:15]I>O.O.C1CCOC1.[NaH]>[CH3:14][N:13]=[C:11]([S:12][CH3:15])[N:2]([CH3:1])[CH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10]|US20200039961A1_0580
1.9.3|[C:8]-[#50&H1&+0&D3:7](-[C:6])-[C:5].[C:4]-[C&H0&+0&D2:3]#[C&H0&+0&D2:2]-[c:1]>>[C:8]-[#50&H0&+0&D4:7](-[C:6])(-[C:5])-[C&H0&+0&D3:2](-[c:1])=[C&H1&+0&D2:3]-[C:4]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[O:11][CH3:12])[CH3:13])[C:14]#[C:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][O:21][C:22]1=[O:23].[CH3:24][CH2:25][CH2:26][CH2:27][SnH:28]([CH2:29][CH2:30][CH2:31][CH3:32])[CH2:33][CH2:34][CH2:35][CH3:36]>c1ccc(cc1)[P](c1ccccc1)(c1ccccc1)[Pd]([P](c1ccccc1)(c1ccccc1)c1ccccc1)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.C1CCOC1>[CH3:24][CH2:25][CH2:26][CH2:27][Sn:28]([CH2:29][CH2:30][CH2:31][CH3:32])([CH2:33][CH2:34][CH2:35][CH3:36])[C:14](=[CH:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][O:21][C:22]1=[O:23])[c:7]1[cH:6][c:5]([c:10]([c:9]([cH:8]1)[CH3:13])[O:11][CH3:12])[C:3](=[O:4])[O:2][CH3:1]|US20170267667A1_0123
2.1.2|[C:7]-[N&H2&+0&D1:6].[C:5]-[C&H1&+0&D3:4](-[N:3])-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C@@&H1&+0&D3:4](-[C:5])-[N:3]|[CH3:1][O:2][C:3](=[O:4])[C@@H:5]([NH2:6])[CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[O:14]=[C:15]([NH:16][CH:17]([C:18](=[O:19])O)[CH:20]([CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[C:28](=[O:29])[OH:30])[O:31][CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1>[Na+].CC([O-])=O.CC([O-])=O.CN(C)C=O.[OH-].[Ca+2]>[CH3:1][O:2][C:3](=[O:4])[C@H:5]([CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[NH:6][C:18](=[O:19])[C@@H:17]([NH:16][C:15](=[O:14])[O:31][CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1)[CH:20]([CH2:21][c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1)[C:28](=[O:29])[OH:30]|EP2504324B1_0348
1.8.2|[O&H0&-&D1:7]-[S&H0&+0&D3:6](=[O&H0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[O&H0&+0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])Cl.[O-:11][S:12](=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>O.CN(C)C=O>[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])[S:12](=[O:13])(=[O:11])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US20150368230A1_0100
2.8.5|[C&H3&D1:6]-[C&H0&+0&D3:5](-[O&H0&-&D1:4])=[S&H0&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Cl>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]([O-:3])=[S:4].[CH3:5][CH:6]([c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[F:13])-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[n:21][c:22]([n:23][o:24]1)[CH2:25][CH2:26]Cl.[K+]>O.O.CN(C)C=O>[CH3:5][CH:6]([c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[F:13])-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[n:21][c:22]([n:23][o:24]1)[CH2:25][CH2:26][S:4][C:2]([CH3:1])=[O:3]|US20110190285A1_0149
1.8.1|[C:7]-[S&H0&+0&D3:6](-[O&H0&-&D1:5])=[O&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:7]-[S&H0&+0&D4:6](=[O&H0&+0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([c:7]([n:8][c:9]2[cH:10][c:11]([c:12]([cH:13][c:14]12)Br)[O:15][CH3:16])-[c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)[C:23]([F:24])([F:25])[F:26])[CH3:27].[CH3:28][CH:29]([CH3:30])[S:31]([O-:32])=[O:33].[Na+]>CS(C)=O.ClCCl.CI.CO.I[Cu].O>[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([c:7]([n:8][c:9]2[cH:10][c:11]([c:12]([cH:13][c:14]12)[S:31](=[O:33])(=[O:32])[CH:29]([CH3:28])[CH3:30])[O:15][CH3:16])-[c:17]1[cH:22][c:21]([cH:20][cH:19][cH:18]1)[C:23]([F:24])([F:25])[F:26])[CH3:27]|EP2981535B1_0144
2.1.2|[C:7]-[C&H1&+0&D3:6](-[C:5])-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:7]-[C@@&H1&+0&D3:6](-[C:5])-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[CH3:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])O)[Cl:10].[NH2:11][CH:12]1[CH2:13][N:14]2[CH2:15][CH2:16][CH:17]1[CH2:18][CH2:19]2>N[C@@H]1CN2CCC1CC2>[CH3:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[NH:11][C@@H:12]1[CH2:13][N:14]2[CH2:19][CH2:18][CH:17]1[CH2:16][CH2:15]2)[Cl:10]|US07799782B2_0800
4.1.24|[C:6]-[C&H0&+0&D2:5]#[N&H0&+0&D1:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D2:3]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[n:13]1[CH2:14][CH:15]([OH:16])[CH2:17][C:18]#[N:19])[NH:20][C:21](=[O:22])[C:23]1([CH2:24][CH2:25]1)[c:26]1[cH:27][cH:28][c:29]2[O:30][C:31]([O:32][c:33]2[cH:34]1)([F:35])[F:36].[N-:37]=[N+:38]=[N-:39].[Na+]>CN(C)C=O.[NH4+].[Cl-]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[n:13]1[CH2:14][CH:15]([OH:16])[CH2:17][c:18]1[n:37][n:38][nH:39][n:19]1)[NH:20][C:21](=[O:22])[C:23]1([CH2:24][CH2:25]1)[c:26]1[cH:27][cH:28][c:29]2[O:30][C:31]([O:32][c:33]2[cH:34]1)([F:35])[F:36]|US20200017481A1_0996
3.11.16|[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-Br.[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([F:7])([F:8])Br.Br[c:9]1[cH:10][cH:11][cH:12][cH:13][n:14]1>CC(=O)OC(C)C.CS(C)=O.[O-]P(=O)(O)O.[K+].[Cu]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([F:7])([F:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][n:14]1|US20200163948A1_1262
1.7.3|[C:7]-[O&H1&+0&D1:6].[C:5]-[C&H1&+0&D3:4](-[N:3])-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:7]-[O&H0&+0&D2:6]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C@@&H1&+0&D3:4](-[C:5])-[N:3]|[CH3:1][CH2:2][OH:3].[CH3:4][S:5](=[O:6])(=[O:7])[NH:8][c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[CH2:15][CH:16]([NH:17][C:18](=[O:19])[O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[C:28](=[O:29])O>N[C@@H](CS)C(=O)O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O>[CH3:1][CH2:2][O:3][C:28](=[O:29])[C@H:16]([CH2:15][c:13]1[cH:12][cH:11][cH:10][c:9]([cH:14]1)[NH:8][S:5]([CH3:4])(=[O:6])=[O:7])[NH:17][C:18](=[O:19])[O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|US20190308934A1_0150
1.8.15|[C&H3&D1:6]-[C&H2&+0&D2:5]-I.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C&H3&D1:6]-[C&H2&+0&D2:5]-[S&H0&+0&D2:1]-[C&H0&+0&D3:3](=[N&H1&+0&D1:4])-[N:2]|[CH3:1][CH2:2]I.[CH3:3][N:4]([CH3:5])[C:6](=[O:7])[NH:8][C:9]([NH2:10])=[S:11]>O.CO.O[Na]>[CH3:1][CH2:2][S:11][C:9](=[NH:10])[NH:8][C:6](=[O:7])[N:4]([CH3:3])[CH3:5]|US07951940B2_0311
2.8.5|[C&H3&D1:6]-[C&H0&+0&D3:5](-[O&H1&+0&D1:4])=[S&H0&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-O>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[C@@H:8]1[CH2:9][S:10][C@H:11]([CH2:12]1)[CH2:13]O.[CH3:14][C:15]([OH:16])=[S:17]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCOC(=O)N=NC(=O)OCC.C1CCOC1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[C@@H:8]1[CH2:9][S:10][C@H:11]([CH2:12]1)[CH2:13][S:17][C:15]([CH3:14])=[O:16]|US20170210723A1_0433
4.1.56|[C:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3]:[c:2]-[C&H2&+0&D2:1]-Br)-O-C>>[C:7]-[N&H0&+0&D3:6]1-[C&H2&+0&D2:1]-[c:2]:[c:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|[CH3:1][C:2]1([O:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[C@H:10]([C@@H:11]1[OH:12])[NH2:13])[S:14](=[O:15])(=[O:16])[C:17]([F:18])([F:19])[F:20])[CH3:21].CO[C:22](=[O:23])[c:24]1[cH:25][cH:26][cH:27][c:28]([c:29]1[CH2:30]Br)[F:31]>CCN(CC)CC>[CH3:1][C:2]1([O:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[C@H:10]([C@@H:11]1[OH:12])[N:13]1[CH2:30][c:29]2[c:28]([cH:27][cH:26][cH:25][c:24]2[C:22]1=[O:23])[F:31])[S:14](=[O:15])(=[O:16])[C:17]([F:18])([F:19])[F:20])[CH3:21]|EP1940835B1_0838
2.1.24|[C:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[C:3])=[O&H0&D1:2].[N&H0&+0&D2:1](-[#11])=[N&+]=[N&-]>>[C:6]-[C&H2&+0&D2:5]-[N&H1&+0&D2:1]-[C&H0&+0&D3:4](-[C:3])=[O&H0&D1:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:7][CH2:8][C:9]([CH2:10][CH2:11]1)=[O:12].[N-]=[N+]=[N:13][Na]>CS(=O)(=O)O.O=C(O)O[Na].ClC(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:11][CH2:10][NH:13][C:9]([CH2:8][CH2:7]1)=[O:12]|US20130203735A1_0258
8.8.18|[C:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[nH:7][c:8]3[c:9]([CH2:10][CH2:11][CH2:12][CH:13]3[C:14](=[O:15])[OH:16])[c:17]2[cH:18]1>Cc1ccccc1C.[Pd]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[nH:7][c:8]3[c:13]([cH:12][cH:11][cH:10][c:9]3[c:17]2[cH:18]1)[C:14](=[O:15])[OH:16]|EP0839806A1_0167
1.8.15|[C:7]-[C&H2&+0&D2:6]-I.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[n:3]):[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[n:3]):[n&H0&+0&D2:2]:[c:1]|Cl.[CH3:1][c:2]1[n:3][c:4]([nH:5][c:6]([c:7]1[Br:8])[CH3:9])=[S:10].[NH2:11][C:12](=[O:13])[CH2:14]I>[OH-].[K+]>[CH3:1][c:2]1[n:3][c:4]([n:5][c:6]([c:7]1[Br:8])[CH3:9])[S:10][CH2:14][C:12]([NH2:11])=[O:13]|US20100190747A1_1536
1.6.6|[c:8]:[c&H0&+0&D3:7](:[c:6])-F.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[c:8]:[c&H0&+0&D3:7](:[c:6])-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]2[n:9][cH:10][nH:11][c:12]21.[O-:13][N+:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][c:20]([cH:21]1)F>O.O.CS(C)=O.[H][H].[NaH]>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]2[c:12]1[n:11][cH:10][n:9]2-[c:20]1[cH:21][c:16]([cH:17][cH:18][cH:19]1)[N+:14]([O-:13])=[O:15]|EP0640085B1_0051
1.8.2|[O&H0&-&D1:7]-[S&H0&+0&D3:6](=[O&H0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[O&H0&+0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Na+].[O-:1][S:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[cH:13]1)-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[F:20].[O:21]=[CH:22][c:23]1[cH:24][cH:25][cH:26][n:27][c:28]1Cl>O.CS(C)=O>[O:21]=[CH:22][c:23]1[cH:24][cH:25][cH:26][n:27][c:28]1[S:2](=[O:3])(=[O:1])[c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[cH:13]1)-[c:14]1[cH:19][cH:18][c:17]([cH:16][cH:15]1)[F:20]|EP1858852B1_0121
1.8.1|[O&H0&-&D1:7]-[S&H0&+0&D3:6](=[O&H0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[O&H0&+0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[Na+].[O-:1][S:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[cH:13]1)-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[F:20].[OH:21][C:22]1([CH2:23][CH2:24][CH2:25]1)[c:26]1[cH:27][cH:28][cH:29][n:30][c:31]1Br>>[O:1]=[S:2](=[O:3])([c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[cH:13]1)-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[F:20])[c:31]1[n:30][cH:29][cH:28][cH:27][c:26]1[C:22]1([CH2:23][CH2:24][CH2:25]1)[OH:21]|US20150252047A1_0689
2.8.5|[C&H3&D1:6]-[C&H0&+0&D3:5](-[O&H0&-&D1:4])=[S&H0&+0&D1:3].[C:2]-[C&H2&+0&D2:1]-Br>>[C&H3&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[C:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH:8]1[CH2:9][CH2:10][CH2:11][N:12]2[CH2:13][CH:14]([C:15]([N:16]12)=[O:17])[CH2:18]Br.[CH3:19][C:20]([O-:21])=[S:22].[K+]>CC(C)=O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH:8]1[CH2:9][CH2:10][CH2:11][N:12]2[CH2:13][CH:14]([C:15]([N:16]12)=[O:17])[CH2:18][S:22][C:20]([CH3:19])=[O:21]|US20160068559A1_0882
7.9.12|[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D2:1]:1>>[C:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[c:3]:[c:2]-[N&H1&+0&D2:1]-1|[ClH:1].[O:2]=[C:3]([OH:4])[c:5]1[cH:6][cH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[n:14]1>CC(=O)O.O=[Pt]=O>[ClH:1].[O:2]=[C:3]([OH:4])[CH:5]1[CH2:6][CH2:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[NH:14]1|US20080188460A1_0120
3.9.6|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Cl:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)I)[Cl:8].[CH3:9][C:10](=[O:11])[CH2:12][CH2:13][CH2:14][C:15]#[N:16]>Clc1cc(cc(c1)I)Cl.CCOCC.O.Cl.[Mg]>[CH3:9][C:10]([OH:11])([CH2:12][CH2:13][CH2:14][C:15]#[N:16])[c:6]1[cH:7][c:2]([cH:3][c:4]([cH:5]1)[Cl:8])[Cl:1]|EP2356113B1_0561
7.9.12|[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[n&H0&+0&D2:3]:[c:2]:[c:1]:1>>[C:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[N&H1&+0&D2:3]-[c:2]:[c:1]-1|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][n:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]12>O[K]>[O:1]=[C:2]([OH:3])[CH:4]1[CH2:5][CH2:6][NH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]21|US20200369677A1_0368
1.7.13|[C:7]-[C&H2&+0&D2:6]-I.[O&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[O&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[c:1]|[O:1]=[C:2]([CH2:3][Cl:4])[CH2:5]I.[O:6]=[c:7]1[cH:8][cH:9][c:10]([cH:11][nH:12]1)[Cl:13]>CC(C)=O.O=S(=O)(O)O.O=[Cr](=O)=O>[O:1]=[C:2]([CH2:3][Cl:4])[CH2:5][O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][n:12]1)[Cl:13]|US20120101083A1_0734
4.1.45|[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H2&+0&D1:4].[c:3]-[N&H0&+0&D2:2]=[C&H0&+0&D2:1]=S>>[n&H0&+0&D2:7]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:4]:[c:5]:[c:6]:1)-[N&H1&+0&D2:2]-[c:3]|[CH3:1][C:2]1([C:3]([NH:4][c:5]2[cH:6][c:7]([c:8]([cH:9][c:10]21)[NH2:11])[NH2:12])=[O:13])[CH3:14].[CH3:15][O:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[N:23]=[C:24]=S>CCN(CC)CC.CCOCC.Cl[Hg][Hg]Cl.CCO.ClCCl>[CH3:15][O:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[NH:23][c:24]1[n:11][c:8]2[cH:9][c:10]3[c:5]([cH:6][c:7]2[nH:12]1)[NH:4][C:3]([C:2]3([CH3:1])[CH3:14])=[O:13]|US20080306064A1_0129
4.1.69|[N:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:5]-[N&H1&+0&D2:4]-[c:3]:[n&H0&+0&D2:2]:[c:1])=O>>[N:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[c:1]|[CH3:1][CH:2]([CH3:3])[NH:4][C:5](=O)[NH:6][NH:7][c:8]1[cH:9][c:10]([cH:11][cH:12][n:13]1)[Br:14]>O=P(Cl)(Cl)Cl>[CH3:1][CH:2]([CH3:3])[NH:4][c:5]1[n:6][n:7][c:8]2[cH:9][c:10]([cH:11][cH:12][n:13]12)[Br:14]|US09708314B2_0850
1.7.16|[C:7]-[O&H1&+0&D1:6].[C:5]-[C@&H1&+0&D3:4]1-[C&H2&+0&D2:3]-[N&H0&+0&D3:2]-1-[C:1]>>[C:7]-[O&H0&+0&D2:6]-[C&H2&+0&D2:3]-[C@&H1&+0&D3:4](-[C:5])-[N&H1&+0&D2:2]-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][CH:10]1[CH2:11][CH2:12]1)[CH2:13][C@@H:14]([OH:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[CH3:22][O:23][C:24](=[O:25])[C@H:26]1[CH2:27][N:28]1[C:29](=[O:30])[O:31][CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1>CC[O+](CC)[B-](F)(F)F.ClC(Cl)Cl>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][CH:10]1[CH2:11][CH2:12]1)[CH2:13][C@@H:14]([O:15][CH2:27][C@@H:26]([NH:28][C:29](=[O:30])[O:31][CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1)[C:24](=[O:25])[O:23][CH3:22])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20070249670A1_0846
1.8.13|[C:7]-[C&H2&+0&D2:6]-Cl.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[n:3]):[n&H1&+0&D2:2]:[n:1]>>[C:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[n:3]):[n&H0&+0&D2:2]:[n:1]|[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[n:6][nH:7][c:8]([n:9]1[CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[N+:17]([O-:18])=[O:19])=[S:20].[CH3:21][O:22][C:23](=[O:24])[CH2:25]Cl>COCCO>[CH3:21][O:22][C:23](=[O:24])[CH2:25][S:20][c:8]1[n:7][n:6][c:5]([n:9]1[CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[N+:17]([O-:18])=[O:19])[CH2:4][CH2:3][CH2:2][CH3:1]|US20080269195A1_0268
4.3.9|[N:7]-[C&H0&+0&D3:6](=[S&H0&+0&D1:5])-[N&H1&+0&D2:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[N:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:5]:[c&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:1|[CH3:1][CH2:2][CH2:3][O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[NH:11][C:12](=[S:13])[NH:14][C:15](=[O:16])[O:17][CH3:18]>N#C[Fe-3](C#N)(C#N)(C#N)(C#N)C#N.O=C(O[K])O[K].O[Na].O.[K+].[K+].[K+]>[CH3:1][CH2:2][CH2:3][O:4][c:5]1[cH:6][c:7]2[s:13][c:12]([n:11][c:8]2[cH:9][cH:10]1)[NH:14][C:15](=[O:16])[O:17][CH3:18]|US20150011528A1_0184
4.2.51|[O&H0&D1:7]=[C&H0&+0&D3:6](-O-C)-O-C.[O&H1&+0&D1:5]-[C:4]-[C:3]-[N&H1&+0&D2:2]-[c:1]>>[O&H0&D1:7]=[C&H0&+0&D3:6]1-[O&H0&+0&D2:5]-[C:4]-[C:3]-[N&H0&+0&D3:2]-1-[c:1]|CO[C:1](=[O:2])OC.[O:3]=[C:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[C:11]([N:12]1[CH2:13][C@H:14]([OH:15])[CH2:16][NH:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[N:24]1[CH2:25][CH2:26][O:27][CH2:28][C:29]1=[O:30])=[O:31]>CN(C)c1ccncc1.O=C(c1ncc[nH]1)c1ncc[nH]1>[O:30]=[C:29]1[CH2:28][O:27][CH2:26][CH2:25][N:24]1[c:21]1[cH:22][cH:23][c:18]([cH:19][cH:20]1)[N:17]1[CH2:16][C@@H:14]([O:15][C:1]1=[O:2])[CH2:13][N:12]1[C:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[C:11]1=[O:31])=[O:3]|EP2970240B1_0210
1.8.12|[C:7]-[C&H2&+0&D2:6]-Br.[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:1]-[C&H0&+0&D3:3](-[N:2])=[N&H0&+0&D2:4]-[C:5]|[CH3:1][C:2]1([S:3][C@@H:4]2[CH:5]([C:6]([N:7]2[CH:8]1[c:9]1[n:10][n:11][n:12][nH:13]1)=[O:14])[NH:15][C:16](=[O:17])[CH2:18]Br)[CH3:19].[CH3:20][CH2:21][NH:22][C:23](=[S:24])[NH:25][CH2:26][CH3:27]>CCN(CC)CC.ClCCl>[CH3:27][CH2:26][N:25]=[C:23]([NH:22][CH2:21][CH3:20])[S:24][CH2:18][C:16](=[O:17])[NH:15][CH:5]1[C:6]([N:7]2[CH:8]([C:2]([S:3][C@H:4]12)([CH3:1])[CH3:19])[c:9]1[n:10][n:11][n:12][nH:13]1)=[O:14]|EP0888292B1_0146
1.7.16|[C:7]-[O&H1&+0&D1:6].[C:5]-[C&H1&+0&D3:4]1-[C&H2&+0&D2:3]-[N&H0&+0&D3:2]-1-[C:1]>>[C:7]-[O&H0&+0&D2:6]-[C&H2&+0&D2:3]-[C@@&H1&+0&D3:4](-[C:5])-[N&H1&+0&D2:2]-[C:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][N@:7]1[C:8](=[O:9])[O:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[OH:18][CH2:19][C@H:20]([O:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C@H:29]([CH2:30][OH:31])[O:32][CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1>CCOCC.FB(F)F.ClCCl>[CH3:1][O:2][C:3](=[O:4])[C@H:5]([CH2:6][O:18][CH2:19][C@H:20]([O:21][CH2:22][c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1)[C@H:29]([CH2:30][OH:31])[O:32][CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)[NH:7][C:8](=[O:9])[O:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US20180140714A1_0410
4.1.22|[N&H2&+0&D1:7]-[c:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C:2]-[C&H2&+0&D2:1]-Br)-Cl>>[N&H0&+0&D3:7]1(-[c:6])-[C&H2&+0&D2:1]-[C:2]-[C:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)-[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[CH2:14][C:15]12[CH2:16][CH2:17][CH2:18][N:19]1[C:20]([N:21]([C:22]2=[O:23])[c:24]1[cH:25][c:26]([cH:27][c:28]([cH:29]1)[Cl:30])[Cl:31])=[O:32].[O:33]=[C:34](Cl)[CH2:35][CH2:36][CH2:37]Br>CC(C)N(CC)C(C)C.ClCCl>[O:33]=[C:34]1[CH2:35][CH2:36][CH2:37][N:1]1[c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)-[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[CH2:14][C:15]12[CH2:16][CH2:17][CH2:18][N:19]1[C:20]([N:21]([C:22]2=[O:23])[c:24]1[cH:25][c:26]([cH:27][c:28]([cH:29]1)[Cl:30])[Cl:31])=[O:32]|US20200290953A1_0387
3.9.2|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][C@H:10]1[C@H:11]([CH2:12][CH2:13][CH2:14][N:15]1[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[C:23]([CH3:24])=[O:25].Br[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>[NH4+].[Cl-].CCOCC.[Mg]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][C@H:10]1[C@H:11]([CH2:12][CH2:13][CH2:14][N:15]1[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[C:23]([CH3:24])([OH:25])[c:26]1[cH:31][cH:30][cH:29][cH:28][cH:27]1|EP1112998A1_0132
1.8.12|[C:7]-[C&H2&+0&D2:6]-Br.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[n:3]):[n&H1&+0&D2:2]:[n:1]>>[C:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[n:3]):[n&H0&+0&D2:2]:[n:1]|[O:1]=[C:2]1[C@H:3]([C@@H:4]2[N:5]1[C:6](=[C:7]([CH2:8][S:9]2)[CH2:10]Br)[C:11](=[O:12])[O:13][CH:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[NH:27][C:28](=[O:29])[CH2:30][c:31]1[cH:32][cH:33][cH:34][s:35]1.[CH3:36][CH2:37][n:38]1[n:39][n:40][nH:41][c:42]1=[S:43]>CCN(CC)CC.CCOC(C)=O.C1CCOC1.O.O.[Na+].[Cl-].Cl>[CH3:36][CH2:37][n:38]1[n:39][n:40][n:41][c:42]1[S:43][CH2:10][C:7]1[CH2:8][S:9][C@@H:4]2[C@@H:3]([C:2]([N:5]2[C:6]=1[C:11](=[O:12])[O:13][CH:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)=[O:1])[NH:27][C:28](=[O:29])[CH2:30][c:31]1[cH:32][cH:33][cH:34][s:35]1|US20070281937A1_0586
1.8.13|[C:7]-[C&H2&+0&D2:6]-Cl.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6]Cl.[O:7]=[c:8]1[nH:9][cH:10][c:11]([c:12]([nH:13]1)=[S:14])[F:15]>CCO.[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][S:14][c:12]1[n:13][c:8]([nH:9][cH:10][c:11]1[F:15])=[O:7]|EP1235833B1_0065
1.8.13|[C:7]-[C&H2&+0&D2:6]-Cl.[C:5]-[C&H0&+0&D3:4](=[S&H0&+0&D1:3])-[N&H1&+0&D2:2]-[c:1]>>[C:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:3]-[C&H0&+0&D3:4](-[C:5])=[N&H0&+0&D2:2]-[c:1]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5]Cl.[O-:6][N+:7](=[O:8])[c:9]1[cH:10][cH:11][c:12]2[NH:13][C:14]([CH2:15][N:16]=[C:17]([c:18]2[cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)=[S:26]>O.CN(C)C=O.[NaH]>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][S:26][C:14]1[CH2:15][N:16]=[C:17]([c:18]2[cH:19][c:9]([cH:10][cH:11][c:12]2[N:13]=1)[N+:7]([O-:6])=[O:8])[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US05521170A
1.7.18|[C:7]-[C&H1&+0&D3:6](-[O&H1&+0&D1:5])-[O:4].[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[C:7]-[C@&H1&+0&D3:6](-[O&H0&+0&D2:5]-[C&H0&+0&D3:2](-[C:3])=[N&H1&+0&D1:1])-[O:4]|[CH3:1][C:2](=[O:3])[O:4][C@H:5]1[C@@H:6]([C@@H:7]([C@@H:8]([O:9][CH:10]1[OH:11])[CH3:12])[O:13][C:14]([CH3:15])=[O:16])[O:17][C:18]([CH3:19])=[O:20].[N:21]#[C:22][C:23]([Cl:24])([Cl:25])[Cl:26]>ClCCl.[NaH]>[CH3:15][C:14](=[O:16])[O:13][C@@H:7]1[C@@H:8]([O:9][C@H:10]([C@H:5]([C@@H:6]1[O:17][C:18]([CH3:19])=[O:20])[O:4][C:2]([CH3:1])=[O:3])[O:11][C:22](=[NH:21])[C:23]([Cl:24])([Cl:25])[Cl:26])[CH3:12]|US09879002B2_0077
4.1.22|[N&H2&+0&D1:7]-[c:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C:2]-[C&H2&+0&D2:1]-Cl)-Cl>>[N&H0&+0&D3:7]1(-[c:6])-[C&H2&+0&D2:1]-[C:2]-[C:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][n:10][c:11]21.[O:12]=[C:13](Cl)[CH2:14][CH2:15][CH2:16]Cl>CCN(CC)CC.COCCOC>[O:12]=[C:13]1[CH2:14][CH2:15][CH2:16][N:1]1[c:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][n:10][c:11]21|US08410089B2_1865
2.4.5|[C:7]-[C&H1&+0&D3:6](-[C:5])-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[O:1])-Cl>>[C:7]-[C@@&H1&+0&D3:6](-[C:5])-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[O:1]|[CH2:1]=[CH:2][CH2:3][CH:4]([NH2:5])[C:6](=[O:7])[OH:8].[O:9]=[C:10](Cl)[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>[Na+].C=CC[C@H](N)C(=O)O.[OH-]>[CH2:1]=[CH:2][CH2:3][C@H:4]([NH:5][C:10](=[O:9])[O:11][CH2:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)[C:6](=[O:7])[OH:8]|US09879032B2_0600
1.9.10|[O&H0&+0&D1:7]=[C&H1&+0&D2:6]-[c:5].[O&H0&-&D1:4]-[P&H0&+0&D3:3](-[O:2])-[O:1]>>[O&H1&+0&D1:7]-[C&H1&+0&D3:6](-[c:5])-[P&H0&+0&D4:3](=[O&H0&+0&D1:4])(-[O:2])-[O:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][P:6]([O-:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12].[CH3:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH:20]=[O:21]>C[Si](C)(C)N([Si](C)(C)C)[Li].C1CCOC1>[CH3:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH:20]([OH:21])[P:6](=[O:7])([O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12]|EP2114971B1_0115
1.2.14|[C&H3&D1:6]-[N&H2&+0&D1:5].[C:4]-[C@&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H2&+0&D2:2]-[C@&H1&+0&D3:3](-[C:4])-[O&H1&+0&D1:1]|[O:1]=[C:2]([NH:3][CH2:4][C:5]12[CH2:6][CH:7]3[CH2:8][CH:9]([CH2:10][CH:11]([CH2:12]3)[CH2:13]1)[CH2:14]2)[c:15]1[cH:16][c:17]([n:18][cH:19][c:20]1[Br:21])[O:22][CH2:23][C@@H:24]1[CH2:25][O:26]1.[CH3:27][NH2:28]>C1COCCO1>[CH3:27][NH:28][CH2:25][C@H:24]([OH:26])[CH2:23][O:22][c:17]1[cH:16][c:15]([c:20]([cH:19][n:18]1)[Br:21])[C:2](=[O:1])[NH:3][CH2:4][C:5]12[CH2:6][CH:7]3[CH2:8][CH:9]([CH2:10][CH:11]([CH2:12]3)[CH2:13]1)[CH2:14]2|US09738651B2_0680
5.5.3|[O&H0&+0&D1:7]=[C&H1&+0&D2:6]-[c:5].[O&H1&+0&D1:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-O>>[O&H0&+0&D2:7]1-[C&H1&+0&D3:6](-[O&H0&+0&D2:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-1)-[c:5]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[Cl:9].[OH:10][CH2:11][CH2:12][CH2:13]O>>[Cl:9][c:7]1[cH:6][cH:5][cH:4][c:3]([cH:8]1)[CH:2]1[O:10][CH2:11][CH2:12][CH2:13][O:1]1|EP3372595A1_0265
1.6.4|[n:8]:[c&H0&+0&D3:7](:[n:6])-Cl.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[n:8]:[c&H0&+0&D3:7](:[n:6])-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|[NH2:1][c:2]1[cH:3][c:4]([c:5]2[nH:6][c:7]([n:8][c:9]2[cH:10]1)[CH:11]([F:12])[F:13])[Cl:14].Cl[c:15]1[n:16][c:17]([n:18][c:19]([n:20]1)[N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1)[Cl:27]>CC(C)=O.O=C(O[K])O[K]>[NH2:1][c:2]1[cH:3][c:4]([c:5]2[n:6][c:7]([n:8]([c:9]2[cH:10]1)-[c:15]1[n:20][c:19]([n:18][c:17]([n:16]1)[Cl:27])[N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1)[CH:11]([F:12])[F:13])[Cl:14]|US08541418B2_1163
4.3.9|[C:7]-[C&H0&+0&D3:6](=[S&H0&+0&D1:5])-[N&H1&+0&D2:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:5]:[c&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[O:9][CH3:10])[NH:11][C:12](=[S:13])[C:14]([NH2:15])=[O:16]>N#C[Fe-3](C#N)(C#N)(C#N)(C#N)C#N.O[K].O.[K+].[K+].[K+]>[CH3:10][O:9][c:8]1[cH:7][c:6]2[n:11][c:12]([s:13][c:5]2[cH:4][c:3]1[O:2][CH3:1])[C:14]([NH2:15])=[O:16]|US20080269195A1_0228
4.1.69|[C:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:5]-[N&H1&+0&D2:4]-[c:3]:[n&H0&+0&D2:2]:[n:1])=O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[n:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=O)[NH:6][NH:7][c:8]1[cH:9][cH:10][c:11]([n:12][n:13]1)[Cl:14]>CCOC(C)=O>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][n:7][c:8]2[cH:9][cH:10][c:11]([n:12][n:13]12)[Cl:14]|EP3089980B1_0546
4.1.34|[C:7]-[C&H2&+0&D2:6]-[C&H1&+0&D2:5]=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[n&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:3]:1:[c:4]|Cl.N[NH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[Br:8].O=[CH:9][CH2:10][CH2:11][CH2:12][CH2:13][Cl:14]>O.CC(=O)O>[Cl:14][CH2:13][CH2:12][CH2:11][c:10]1[cH:9][nH:1][c:2]2[cH:3][cH:4][c:5]([cH:6][c:7]12)[Br:8]|US20070149514A1_0192
1.7.13|[C:7]-[C&H2&+0&D2:6]-Br.[O&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[n:1]>>[C:7]-[C&H2&+0&D2:6]-[O&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[n:1]|[N:1]#[C:2][CH2:3]Br.[O:4]=[c:5]1[nH:6][n:7]2[c:8]([n:9][n:10][c:11]2[cH:12][c:13]1-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)-[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>CN(C)C=O.[NaH]>[N:1]#[C:2][CH2:3][O:4][c:5]1[n:6][n:7]2[c:8]([n:9][n:10][c:11]2[cH:12][c:13]1-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)-[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US09994550B2_0183
1.8.12|[C:7]-[C&H2&+0&D2:6]-Br.[C:5]-[C&H0&+0&D3:4](=[S&H0&+0&D1:3])-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:3]-[C&H0&+0&D3:4](-[C:5])=[N&H0&+0&D2:2]-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][CH2:13]1)[N:14]=[C:15]([C:16]([NH:17]2)=[S:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Br:25].[O:26]=[C:27]([CH2:28]Br)[NH:29][c:30]1[cH:31][n:32][c:33]2[cH:34][cH:35][cH:36][cH:37][c:38]2[cH:39]1>CCN(CC)CC.ClCCl>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][CH2:13]1)[N:14]=[C:15]([C:16](=[N:17]2)[S:18][CH2:28][C:27](=[O:26])[NH:29][c:30]1[cH:31][n:32][c:33]2[cH:34][cH:35][cH:36][cH:37][c:38]2[cH:39]1)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Br:25]|US20200377503A1_0183
1.8.13|[C:7]-[C&H2&+0&D2:6]-Cl.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[n:3]):[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[n:3]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][n:2]1[cH:3][n:4][c:5]2[c:6]([n:7][c:8]([nH:9][c:10]21)=[S:11])[CH3:12].[NH2:13][C:14](=[O:15])[CH2:16]Cl>O.[Na+].[O-]C(=O)O>[CH3:1][n:2]1[cH:3][n:4][c:5]2[c:10]1[n:9][c:8]([n:7][c:6]2[CH3:12])[S:11][CH2:16][C:14]([NH2:13])=[O:15]|US20100190747A1_1257
3.9.2|[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[O&H1&+0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][n:8][cH:9]1.Br[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[O:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>[NH4+].[Cl-].II.C1CCOC1.[Mg]>[CH3:1][C:2]([OH:3])([c:10]1[cH:15][cH:14][c:13]([cH:12][cH:11]1)[O:16][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1)[c:4]1[cH:9][n:8][cH:7][cH:6][cH:5]1|US20180362451A1_0317
4.1.94|[C:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[S&H0&+0&D1:2]=[C&H0&+0&D2:1]=S>>[C:7]-[n&H0&+0&D3:6]1:[c&H0&+0&D3:1](:[n&H0&+0&D2:3]:[c:4]:[c:5]:1)-[S&H1&+0&D1:2]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH:8][CH2:9][CH2:10][CH2:11][OH:12].[S:13]=[C:14]=S>O.CCO.O[K]>[OH:12][CH2:11][CH2:10][CH2:9][n:8]1[c:7]2[cH:6][cH:5][cH:4][cH:3][c:2]2[n:1][c:14]1[SH:13]|EP1167360A1_0097
4.2.17|[N&H2&+0&D1:7]-[c:6]:[c:5]-[O&H1&+0&D1:4].[c:3]-[N&H0&+0&D2:2]=[C&H0&+0&D2:1]=S>>[n&H0&+0&D2:7]1:[c&H0&+0&D3:1](:[o&H0&+0&D2:4]:[c:5]:[c:6]:1)-[N&H1&+0&D2:2]-[c:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[OH:14])[NH2:15].[CH3:16][c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[N:23]=[C:24]=S>CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][c:8]1[cH:13][c:12]2[o:14][c:24]([n:15][c:11]2[cH:10][cH:9]1)[NH:23][c:22]1[cH:21][cH:20][cH:19][cH:18][c:17]1[CH3:16]|US06562851B2
1.6.2|[c:8]:[c&H0&+0&D3:7](:[c:6])-Br.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[c:8]:[c&H0&+0&D3:7](:[c:6])-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|Br[c:1]1[cH:2][cH:3][cH:4][c:5]([cH:6]1)-[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.[cH:13]1[cH:14][cH:15][c:16]2[nH:17][cH:18][n:19][c:20]2[n:21]1>CN1CCCC1=O.O=C(O[K])O[K].[Cu]>[cH:10]1[cH:11][cH:12][c:7]([cH:8][cH:9]1)-[c:5]1[cH:4][cH:3][cH:2][c:1]([cH:6]1)-[n:19]1[cH:18][n:17][c:16]2[cH:15][cH:14][cH:13][n:21][c:20]21|US10112938B2_0731
1.8.12|[C:7]-[C&H2&+0&D2:6]-Br.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[n:3]):[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[n:3]):[n&H0&+0&D2:2]:[c:1]|[NH2:1][c:2]1[cH:3][cH:4][nH:5][c:6]([n:7]1)=[S:8].[O:9]=[C:10]1[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[C:17]([N:18]1[CH2:19][CH2:20][CH2:21][CH2:22]Br)=[O:23]>CCO.C1=NCCCN2CCCCC12>[NH2:1][c:2]1[cH:3][cH:4][n:5][c:6]([n:7]1)[S:8][CH2:22][CH2:21][CH2:20][CH2:19][N:18]1[C:10]([c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[C:17]1=[O:23])=[O:9]|US20100190747A1_1439
1.8.12|[C:7]-[C&H2&+0&D2:6]-Br.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][C@@:2]12[CH2:3][CH2:4][C@H:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@@:14]1([C@H:15]([CH2:16][CH2:17][C@@H:18]21)[C:19](=[O:20])[CH2:21]Br)[CH3:22])=[O:23])[OH:24].[S:25]=[c:26]1[cH:27][cH:28][cH:29][cH:30][nH:31]1>O.CCOCC.O[Na].C1CCOC1>[CH3:1][C@@:2]12[CH2:3][CH2:4][C@H:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@:14]1([C@H:18]2[CH2:17][CH2:16][C@@H:15]1[C:19](=[O:20])[CH2:21][S:25][c:26]1[cH:27][cH:28][cH:29][cH:30][n:31]1)[CH3:22])=[O:23])[OH:24]|US08916579B2_0152
1.6.4|[c:8]:[c&H0&+0&D3:7](:[n:6])-Cl.[c:5]1:[c:4]:[n&H0&+0&D2:3]:[c:2]:[n&H1&+0&D2:1]:1>>[c:8]:[c&H0&+0&D3:7](:[n:6])-[n&H0&+0&D3:3]1:[c:4]:[c:5]:[n&H0&+0&D2:1]:[c:2]:1|[CH3:1][C@H:2]([NH:3][c:4]1[n:5][cH:6][cH:7][c:8]([n:9]1)Cl)[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH3:16][c:17]1[cH:18][cH:19][c:20]2[n:21][cH:22][nH:23][c:24]2[c:25]1[N+:26]([O-:27])=[O:28]>[Na+].CN(C)C=O.[H-]>[CH3:16][c:17]1[cH:18][cH:19][c:20]2[c:24]([n:23][cH:22][n:21]2-[c:8]2[cH:7][cH:6][n:5][c:4]([n:9]2)[NH:3][C@@H:2]([CH3:1])[c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)[c:25]1[N+:26]([O-:27])=[O:28]|EP1636206B1_0123
1.8.13|[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](-[N:4])=[S&H0&+0&D1:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[C:7]-[N&H0&+0&D2:6]=[C&H0&+0&D3:5](-[N:4])-[S&H0&+0&D2:3]-[C&H2&+0&D2:1]-[c:2]|[CH3:1][O:2][C:3](=[O:4])[NH:5][C:6](=[S:7])[NH:8][CH:9]1[C:10](=[CH:11][CH:12]=[CH:13][C:14]1=[NH:15])[CH2:16][c:17]1[cH:18][cH:19][cH:20][o:21]1.Cl[CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>O.CS(C)=O.O[Na]>[CH3:1][O:2][C:3](=[O:4])[N:5]=[C:6]([NH:8][CH:9]1[C:14]([CH:13]=[CH:12][CH:11]=[C:10]1[CH2:16][c:17]1[cH:18][cH:19][cH:20][o:21]1)=[NH:15])[S:7][CH2:22][c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1|US04855301A
4.2.51|[C:7]-[N&H1&+0&D2:6]-[C:5]-[C:4]-[O&H1&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C)-O-C>>[C:7]-[N&H0&+0&D3:6]1-[C:5]-[C:4]-[O&H0&+0&D2:3]-[C&H0&+0&D3:1]-1=[O&H0&D1:2]|CO[C:1](=[O:2])OC.[OH:3][CH2:4][CH2:5][NH:6][CH2:7][CH2:8][OH:9]>>[O:2]=[C:1]1[O:9][CH2:8][CH2:7][N:6]1[CH2:5][CH2:4][OH:3]|US20200172539A1_0571
1.7.13|[C:7]-[C&H2&+0&D2:6]-Br.[O&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[O&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][n:2]1[c:3]2[cH:4][cH:5][c:6]([cH:7][c:8]2[c:9]2[c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[c:16]([nH:17][c:18]21)=[O:19])[Cl:20].Br[CH2:21][CH:22]1[CH2:23][CH2:24]1>[NaH]>[CH3:1][n:2]1[c:3]2[cH:4][cH:5][c:6]([cH:7][c:8]2[c:9]2[c:18]1[n:17][c:16]([c:15]1[cH:14][cH:13][cH:12][cH:11][c:10]21)[O:19][CH2:21][CH:22]1[CH2:23][CH2:24]1)[Cl:20]|US20170349594A1_0951
1.7.13|[C:7]-[C&H2&+0&D2:6]-Cl.[O&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[O&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][n:2]1[c:3]2[cH:4][cH:5][c:6]([cH:7][c:8]2[c:9]2[c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[c:16]([nH:17][c:18]21)=[O:19])[Cl:20].Cl[CH2:21][CH2:22][N:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1>[NaH]>[CH3:1][n:2]1[c:3]2[cH:4][cH:5][c:6]([cH:7][c:8]2[c:9]2[c:18]1[n:17][c:16]([c:15]1[cH:14][cH:13][cH:12][cH:11][c:10]21)[O:19][CH2:21][CH2:22][N:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1)[Cl:20]|US20200291026A1_0368
1.1.3|[C&H3&+0&D1:7]-I.[c:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4](:[s:3])-[N&H1&+0&D2:2]-[c:1]>>[C&H3&+0&D1:7]-[n&H0&+0&D3:5](:[c:6]):[c&H0&+0&D3:4](:[s:3])=[N&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[Cl:14])[NH:15][c:16]1[n:17][cH:18][cH:19][s:20]1.[CH3:21]I>CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH3:7])[c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[Cl:14])[N:15]=[c:16]1[s:20][cH:19][cH:18][n:17]1[CH3:21]|US06133258A
4.1.56|[N&H2&+0&D1:7]-[c:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3]:[c:2]-[C&H2&+0&D2:1]-Br)-O-C>>[N&H0&+0&D3:7]1(-[c:6])-[C&H2&+0&D2:1]-[c:2]:[c:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|CO[C:1](=[O:2])[c:3]1[c:4]([cH:5][cH:6][cH:7][c:8]1[N+:9]([O-:10])=[O:11])[CH2:12]Br.[CH3:13][C:14]([CH3:15])([CH3:16])[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[NH2:23]>CC(C)N(CC)C(C)C.CC(C)(C)O>[CH3:13][C:14]([CH3:15])([CH3:16])[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[N:23]1[CH2:12][c:4]2[cH:5][cH:6][cH:7][c:8]([c:3]2[C:1]1=[O:2])[N+:9]([O-:10])=[O:11]|US20070032475A1_0885
1.2.14|[C:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[O:3]-[N&H1&+0&D2:2]-[S:1]>>[C:7]-[C@&H1&+0&D3:6](-[C&H2&+0&D2:5]-[N&H0&+0&D3:2](-[O:3])-[S:1])-[O&H1&+0&D1:4]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]([CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[CH:17]1[CH2:18][O:19]1.[CH3:20][O:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[S:28](=[O:29])(=[O:30])[NH:31][O:32][CH:33]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1>>[CH3:20][O:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[S:28](=[O:29])(=[O:30])[N:31]([CH2:18][C@@H:17]([OH:19])[C@H:9]([CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[O:32][CH:33]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1|
8.1.34|[C:7]-[C&H0&+0&D3:6](-[O&H1&+0&D1:5])=[C&H0&+0&D3:4](-[C:3])-[C&H2&+0&D2:2]-[C:1]>>[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[C&H0&+0&D3:4](-[C:3])=[C&H1&+0&D2:2]-[C:1]|[CH3:1][C:2]1([CH2:3][C@H:4]2[C@H:5]3[C:6]([CH2:7][C@H:8]4[C@@:9]([CH2:10][CH2:11][C@@H:12]5[C@@:13]4([CH2:14][C:15](=[C:16]([C:17]5([CH3:18])[CH3:19])[OH:20])[C:21]#[N:22])[CH3:23])([C@@:24]3([CH2:25][CH2:26][C@:27]2([CH2:28][CH2:29]1)[CH2:30][S:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)[CH3:38])[CH3:39])=[O:40])[CH3:41]>>[CH3:1][C:2]1([CH2:29][CH2:28][C@@:27]2([CH2:26][CH2:25][C@@:24]3([C@H:5]([C:6]([CH2:7][C@H:8]4[C@:9]3([CH2:10][CH2:11][C@H:12]3[C:17]([C:16]([C:15](=[CH:14][C@:13]43[CH3:23])[C:21]#[N:22])=[O:20])([CH3:18])[CH3:19])[CH3:39])=[O:40])[C@@H:4]2[CH2:3]1)[CH3:38])[CH2:30][S:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)[CH3:41]|US20200299230A1_0753
9.7.90|[N:7]-[C&H0&+0&D3:6](=[S&H0&+0&D1:5])-[O&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[N:7]-[C&H0&+0&D3:6](-[S&H0&+0&D2:5]-[c&H0&+0&D3:3](:[c:2]):[c:1])=[O&H0&+0&D1:4]|[CH3:1][N:2]([CH3:3])[C:4](=[S:5])[O:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[S:13](=[O:14])(=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>>[CH3:1][N:2]([CH3:3])[C:4](=[O:6])[S:5][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[S:13](=[O:14])(=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20190315793A1_0316
4.1.45|[C:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[N&H0&+0&D1:2]#[C&H0&+0&D2:1]-Br>>[C:7]-[n&H0&+0&D3:6]1:[c&H0&+0&D3:1](-[N&H2&+0&D1:2]):[n&H0&+0&D2:3]:[c:4]:[c:5]:1|[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH2:8][CH2:9][CH2:10][NH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[NH2:18].[N:19]#[C:20]Br>O.CC(C)=O.[OH-].[K+]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[CH2:8][CH2:9][CH2:10][n:11]1[c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[n:18][c:20]1[NH2:19]|US20200330556A1_0231
1.2.14|[C:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C:7]-[C@&H1&+0&D3:6](-[C&H2&+0&D2:5]-[N&H0&+0&D3:2](-[C:3])-[c:1])-[O&H1&+0&D1:4]|[F:1][C:2]([F:3])([F:4])[O:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[C@H:12]1[CH2:13][O:14][c:15]2[c:16]([NH:17]1)[cH:18][cH:19][cH:20][c:21]2-[c:22]1[cH:23][cH:24][cH:25][c:26]([cH:27]1)[O:28][C:29]([F:30])([F:31])[F:32].[F:33][C:34]([F:35])([F:36])[CH:37]1[CH2:38][O:39]1>FC(F)(F)Oc1cccc(c1)[C@H]1COc2c(N1)cccc2-c1cccc(c1)OC(F)(F)F.ClCCl>[OH:39][C@@H:37]([CH2:38][N:17]1[c:16]2[cH:18][cH:19][cH:20][c:21]([c:15]2[O:14][CH2:13][C@@H:12]1[c:10]1[cH:9][cH:8][cH:7][c:6]([cH:11]1)[O:5][C:2]([F:1])([F:3])[F:4])-[c:22]1[cH:23][cH:24][cH:25][c:26]([cH:27]1)[O:28][C:29]([F:30])([F:31])[F:32])[C:34]([F:33])([F:35])[F:36]|US09688630B2_0208
7.5.1|[C:6]-[C&H1&+0&D3:5](-[O&H0&+0&D2:4]-C(-C)=O)-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C:6]-[C@@&H1&+0&D3:5](-[O&H1&+0&D1:4])-[C@@&H1&+0&D3:3](-[O&H1&+0&D1:2])-[c:1]|CC(=O)[O:1][CH:2]1[CH2:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][c:9]([c:10]2[C:11]1=[O:12])[Cl:13]>CCN(CC)CC.O=CO.ClCCl>[OH:12][C@H:11]1[c:10]2[c:5]([cH:6][cH:7][cH:8][c:9]2[Cl:13])[CH2:4][CH2:3][C@H:2]1[OH:1]|US20180057449A1_0320
1.7.17|[C&H3&D1:6]-[C@@&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[O&H0&+0&D2:3]-1.[O&H1&+0&D1:2]-[c:1]>>[C&H3&D1:6]-[C@&H1&+0&D3:5](-[C&H2&+0&D2:4]-[O&H0&+0&D2:2]-[c:1])-[O&H1&+0&D1:3]|[OH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.[CH3:15][C@H:16]1[CH2:17][O:18]1>CCCC[N+](CCCC)(CCCC)CCCC.Cc1ccccc1.ClC(Cl)Cl.O[Na].O.[Br-]>[CH3:15][C@H:16]([OH:18])[CH2:17][O:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1|EP3753939A1_0979
1.2.14|[C:7]-[C@&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[C&H1&+0&D3:6](-[C&H2&+0&D2:5]-[N&H0&+0&D3:2](-[C:3])-[C:1])-[O&H1&+0&D1:4]|[O:1]=[C:2]([NH:3][CH:4]1[CH2:5][CH2:6][NH:7][CH2:8][CH2:9]1)[CH:10]([CH2:11][CH2:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[CH2:20][CH2:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[cH:29]1[cH:30][c:31]([c:32]2[cH:33][cH:34][cH:35][n:36][c:37]2[cH:38]1)[O:39][CH2:40][C@H:41]1[CH2:42][O:43]1>CC(C)O>[O:1]=[C:2]([NH:3][CH:4]1[CH2:9][CH2:8][N:7]([CH2:6][CH2:5]1)[CH2:42][CH:41]([OH:43])[CH2:40][O:39][c:31]1[cH:30][cH:29][cH:38][c:37]2[n:36][cH:35][cH:34][cH:33][c:32]21)[CH:10]([CH2:11][CH2:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[CH2:20][CH2:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|US07074800B1_1845
1.7.17|[C:7]-[C&H1&+0&D3:6]1-[O&H0&+0&D2:5]-[C&H1&+0&D3:4]-1-[C:3].[O&H1&+0&D1:2]-[c:1]>>[C:7]-[C@&H1&+0&D3:6](-[O&H1&+0&D1:5])-[C&H1&+0&D3:4](-[C:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3][c:4]1[n:5][c:6]([n:7]([c:8]([c:9]1[CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)-[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[C:23]#[N:24])=[O:25])-[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[OH:32])[CH2:33][CH3:34].[CH2:35]1[CH2:36][CH:37]2[O:38][CH:39]2[CH2:40]1>CC(=O)N(C)C.O=C(O[Cs])O[Cs]>[CH3:34][CH2:33][c:6]1[n:5][c:4]([c:9]([c:8]([n:7]1-[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[O:32][CH:37]1[CH2:36][CH2:35][CH2:40][C@H:39]1[OH:38])=[O:25])[CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)-[c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[C:23]#[N:24])[CH2:3][CH2:2][CH3:1]|EP0221725B1_0037
3.7.2|[C&H1&D1:6]#[C&H0&+0&D2:5]-[#12]-Br.[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H1&D1:6]#[C&H0&+0&D2:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[O&H1&+0&D1:1]|[CH:1]#[C:2][Mg]Br.[CH3:3][CH2:4][S:5][CH2:6][C:7]([CH3:8])=[O:9]>[NH4+].[Cl-]>[CH:1]#[C:2][C:7]([CH3:8])([OH:9])[CH2:6][S:5][CH2:4][CH3:3]|US20110086834A1_0725
1.7.13|[O&H0&+0&D1:7]=[c&H0&+0&D3:6](:[c:5]):[n&H1&+0&D2:4]:[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[O&H0&+0&D2:7](-[C&H2&+0&D2:1]-[c:2])-[c&H0&+0&D3:6](:[c:5]):[n&H0&+0&D2:4]:[c:3]|[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][c:6]2[nH:7][c:8]([cH:9][cH:10][c:11]12)=[O:12].Br[CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>Cc1ccccc1.[O-]C([O-])=O.[Ag+].[Ag+]>[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][c:6]2[n:7][c:8]([cH:9][cH:10][c:11]12)[O:12][CH2:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1|EP2588455B1_0551
4.1.29|[C&H3&+0&D1:7]-[C&H0&+0&D3:6](-[C:5])=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[C&H1&+0&D2:1]=O>>[c&H1&+0&D2:7]1:[c&H1&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][N:7]1[C:8]([C@H:9]([CH2:10][C@H:11]1[CH3:12])[CH2:13][CH2:14][C:15]([CH3:16])=O)=[O:17].[NH2:18][c:19]1[n:20][cH:21][cH:22][cH:23][c:24]1[CH:25]=O>CCO.O=C(O)[C@@H]1CCCN1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][N:7]1[C:8]([C@H:9]([CH2:10][C@H:11]1[CH3:12])[CH2:13][CH2:14][c:15]1[cH:16][cH:25][c:24]2[cH:23][cH:22][cH:21][n:20][c:19]2[n:18]1)=[O:17]|US20200123152A1_0599
3.7.2|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[#12]-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][CH:2]([CH3:3])[Mg]Br.[O:4]=[CH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[Br:12]>C1CCOC1>[CH3:1][CH:2]([CH3:3])[CH:5]([OH:4])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[Br:12]|US20130012708A1_0432
3.7.2|[C&H2&D1:6]=[C&H1&+0&D2:5]-[#12]-Br.[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H2&D1:6]=[C&H1&+0&D2:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[O&H1&+0&D1:1]|[CH2:1]=[CH:2][Mg]Br.[CH3:3][CH2:4][CH2:5][CH2:6][C:7]([CH3:8])=[CH:9][CH2:10][CH2:11][C:12]([CH3:13])=[O:14]>>[CH2:1]=[CH:2][C:12]([CH3:13])([OH:14])[CH2:11][CH2:10][CH:9]=[C:7]([CH3:8])[CH2:6][CH2:5][CH2:4][CH3:3]|US20190076539A1_1241
1.7.13|[O&H0&+0&D1:7]=[c&H0&+0&D3:6](:[c:5]):[n&H1&+0&D2:4]:[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:7](-[C&H2&+0&D2:1]-[c:2])-[c&H0&+0&D3:6](:[c:5]):[n&H0&+0&D2:4]:[c:3]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[cH:12][c:13]([c:14]([nH:15][c:16]1-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23])=[O:24])[C:25]#[N:26].Cl[CH2:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>CC(C)=O.CN(C)C=O.[O-]C([O-])=O.[Ag+].[Ag+]>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[cH:12][c:13]([c:14]([n:15][c:16]1-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23])[O:24][CH2:27][c:28]1[cH:33][cH:32][cH:31][cH:30][cH:29]1)[C:25]#[N:26]|US20180030003A1_0844
5.5.2|[O&H0&+0&D1:7]=[C&H0&+0&D3:6](-[c:5])-[c:4].[O&H1&+0&D1:3]-[C:2]-[C&H2&+0&D2:1]-O>>[O&H0&+0&D2:7]1-[C&H2&+0&D2:1]-[C:2]-[O&H0&+0&D2:3]-[C&H0&+0&D4:6]-1(-[c:5])-[c:4]|[O:1]=[C:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Br:15].[OH:16][CH2:17][CH2:18]O>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[Br:15][c:12]1[cH:13][cH:14][c:9]([cH:10][cH:11]1)[C:2]1([O:1][CH2:18][CH2:17][O:16]1)[c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1|US20130296363A1_0592
1.8.13|[S&H0&+0&D1:7]=[c&H0&+0&D3:6](:[n:5]):[n&H1&+0&D2:4]:[n:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[S&H0&+0&D2:7](-[C&H2&+0&D2:1]-[c:2])-[c&H0&+0&D3:6](:[n:5]):[n&H0&+0&D2:4]:[n:3]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9]Cl.[NH2:10][CH2:11][CH2:12][n:13]1[n:14][n:15][nH:16][c:17]1=[S:18].Cl>CCN(CC)CC.CN(C)C=O.CC(C)=O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][S:18][c:17]1[n:16][n:15][n:14][n:13]1[CH2:12][CH2:11][NH2:10]|EP0409332A2_0070
1.6.2|[N&H2&+0&D1:7]-[c&H0&+0&D3:6](:[c:5]):[n&H0&+0&D2:4]:[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[N&H1&+0&D1:7]=[c&H0&+0&D3:6](:[c:5]):[n&H0&+0&D3:4](:[c:3])-[C&H2&+0&D2:1]-[c:2]|[NH2:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][n:8][c:9]1[NH2:10])[Cl:11].[F:12][C:13]([F:14])([F:15])[c:16]1[cH:17][cH:18][c:19]([o:20]1)[CH2:21]Br.CO.[ClH:22]>CCOC(C)=O.CN(C)C=O.CO>[NH:10]=[c:9]1[c:4]([cH:5][c:6]([cH:7][n:8]1[CH2:21][c:19]1[cH:18][cH:17][c:16]([o:20]1)[C:13]([F:12])([F:14])[F:15])[Cl:11])[C:2]([NH2:1])=[O:3].[ClH:22]|US10844044B2_1252
4.2.22|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[O&H1&+0&D1:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:6](-[C:5]):[o&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1]|[CH:1]#[C:2][CH2:3][c:4]1[n:5][c:6]([o:7][c:8]1[CH3:9])-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[O:16]=[CH:17][c:18]1[cH:19][cH:20][c:21]([c:22]([cH:23]1)I)[OH:24]>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.c1ccncc1.[O-2].[Cu+].[Cu+]>[CH3:9][c:8]1[o:7][c:6]([n:5][c:4]1[CH2:3][c:2]1[cH:1][c:22]2[cH:23][c:18]([cH:19][cH:20][c:21]2[o:24]1)[CH:17]=[O:16])-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|EP3057586B1_1336
1.8.12|[S&H0&+0&D1:7]=[c&H0&+0&D3:6](:[n:5]):[n&H1&+0&D2:4]:[c:3].[c:2]-[C&H2&+0&D2:1]-Br>>[S&H0&+0&D2:7](-[C&H2&+0&D2:1]-[c:2])-[c&H0&+0&D3:6](:[n:5]):[n&H0&+0&D2:4]:[c:3]|[CH3:1][n:2]1[c:3]([c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[nH:10][c:11]1=[S:12])=[O:13].[O:14]=[C:15]([c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22])[c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[CH2:29]Br>[Na+].CN(C)C=O.[O-]C(=O)O.[NaH]>[CH3:1][n:2]1[c:3]([c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[n:10][c:11]1[S:12][CH2:29][c:26]1[cH:25][cH:24][c:23]([cH:28][cH:27]1)[C:15](=[O:14])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[Cl:22])=[O:13]|US20200085053A1_0470
1.8.13|[S&H0&+0&D1:7]=[c&H0&+0&D3:6](:[n:5]):[n&H1&+0&D2:4]:[c:3].[c:2]-[C&H2&+0&D2:1]-Cl>>[S&H0&+0&D2:7](-[C&H2&+0&D2:1]-[c:2])-[c&H0&+0&D3:6](:[n:5]):[n&H0&+0&D2:4]:[c:3]|Cl.[CH3:1][O:2][c:3]1[cH:4][c:5]2[CH2:6][CH2:7][CH2:8][n:9]3[c:10]2[c:11]([cH:12]1)[nH:13][c:14]3=[S:15].Cl[CH2:16][c:17]1[cH:18][cH:19][cH:20][c:21]([n:22]1)-[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>CCO.O[Na]>[CH3:1][O:2][c:3]1[cH:12][c:11]2[n:13][c:14]([n:9]3[CH2:8][CH2:7][CH2:6][c:5]([cH:4]1)[c:10]23)[S:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][c:21]([n:22]1)-[c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1|EP1479671A1_0152
3.7.2|[C&H3&D1:6]-[C&H2&+0&D2:5]-[#12]-Br.[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&D1:6]-[C&H2&+0&D2:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[O&H1&+0&D1:2])-[c:1]|[CH2:1]=[CH:2][c:3]1[cH:4][n:5][c:6]([c:7]([c:8]1[C:9]([CH3:10])=[O:11])[OH:12])[CH3:13].[CH3:14][CH2:15][Mg]Br>C1CCOC1>[CH2:1]=[CH:2][c:3]1[cH:4][n:5][c:6]([c:7]([c:8]1[C:9]([CH3:10])([OH:11])[CH2:15][CH3:14])[OH:12])[CH3:13]|US09439904B2_0645
4.1.3|[C:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C:2]-[C&H2&+0&D2:1]-O-C)-O-C-C>>[C:7]-[N&H0&+0&D3:6]1-[C&H2&+0&D2:1]-[C:2]-[C:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|CO[CH2:1][CH2:2][C:3]1([CH2:4][CH2:5][N:6]([CH2:7][CH2:8]1)[S:9](=[O:10])(=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18])[C:19](=[O:20])OCC.[NH2:21][CH2:22][c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[Cl:29]>Cc1ccccc1.C[Al](C)Cl>[O:10]=[S:9](=[O:11])([c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18])[N:6]1[CH2:7][CH2:8][C:3]2([CH2:4][CH2:5]1)[CH2:2][CH2:1][N:21]([C:19]2=[O:20])[CH2:22][c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[Cl:29]|US20170260185A1_0724
3.9.79|[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#3]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[O&H1&+0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[s:5][c:6]([n:7][c:8]1[CH3:9])[CH3:10].[cH:11]1[cH:12][cH:13][c:14]([cH:15][n:16]1)[Li]>[Na+].CCOCC.[O-]C(=O)O>[CH3:10][c:6]1[n:7][c:8]([c:4]([s:5]1)[C:2]([CH3:1])([OH:3])[c:14]1[cH:13][cH:12][cH:11][n:16][cH:15]1)[CH3:9]|US07989449B2_0588
5.5.2|[C:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[O&H1&+0&D1:3]-[C:2]-[C&H2&+0&D2:1]-O>>[C:7]-[C&H0&+0&D4:6]1(-[C:5])-[O&H0&+0&D2:4]-[C&H2&+0&D2:1]-[C:2]-[O&H0&+0&D2:3]-1|[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][C:8]([CH2:9][CH2:10]1)=[O:11].[OH:12][CH2:13][CH2:14]O>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][C:8]2([CH2:9][CH2:10]1)[O:11][CH2:14][CH2:13][O:12]2|US07425634B2_1280
1.2.14|[C:7]-[C&H1&+0&D3:6]1-[O&H0&+0&D2:5]-[C&H1&+0&D3:4]-1-[C:3].[N&H2&+0&D1:2]-[c:1]>>[C:7]-[C@&H1&+0&D3:6](-[O&H1&+0&D1:5])-[C@&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:2]-[c:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[Cl:8])[Cl:9].[CH2:10]1[CH2:11][CH:12]2[O:13][CH:14]2[CH2:15]1>>[OH:13][C@@H:12]1[CH2:11][CH2:10][CH2:15][C@H:14]1[NH:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[Cl:8])[Cl:9]|US20200392149A1_0821
3.7.3|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[#12]-Cl.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[S:16][CH2:17][CH2:18][CH:19]=[O:20].[CH3:21][CH:22]([CH3:23])[Mg]Cl>C1CCOC1.O.Cl>[CH3:21][CH:22]([CH3:23])[CH:19]([OH:20])[CH2:18][CH2:17][S:16][c:7]1[cH:8][c:9]([c:10]([c:5]([cH:6]1)[C:2]([CH3:1])([CH3:3])[CH3:4])[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15]|US07994209B2_0376
3.7.2|[C&H1&D1:6]#[C&H0&+0&D2:5]-[#12]-Br.[C&H3&D1:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H1&D1:6]#[C&H0&+0&D2:5]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[O&H1&+0&D1:2])-[c:1]|[CH:1]#[C:2][Mg]Br.[CH3:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)-[c:12]1[cH:13][cH:14][n:15]2[n:16][c:17]([cH:18][c:19]2[cH:20]1)-[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[F:27]>C1CCOC1>[CH:1]#[C:2][C:4]([CH3:3])([OH:5])[c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)-[c:12]1[cH:13][cH:14][n:15]2[n:16][c:17]([cH:18][c:19]2[cH:20]1)-[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[F:27]|EP3380649B1_0113
1.6.2|[C:7]-[C&H2&+0&D2:6]-Br.[N&H2&+0&D1:5]-[c&H0&+0&D3:4](:[s:3]):[n&H0&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:4](=[N&H1&+0&D1:5]):[s:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][n:7][c:8]([s:9]1)[NH2:10].Br[CH2:11][CH:12]1[CH2:13][CH2:14][CH2:15]1>>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][n:7]([c:8]([s:9]1)=[NH:10])[CH2:11][CH:12]1[CH2:15][CH2:14][CH2:13]1|US08546583B2_0453
1.6.4|[C:7]-[C&H2&+0&D2:6]-Cl.[N&H2&+0&D1:5]-[c&H0&+0&D3:4](:[s:3]):[n&H0&+0&D2:2]:[c:1]>>[C:7]-[C&H2&+0&D2:6]-[n&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:4](=[N&H1&+0&D1:5]):[s:3]|[CH3:1][C:2](=[O:3])[NH:4][CH2:5][CH2:6]Cl.[NH2:7][c:8]1[n:9][c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]2[s:16]1)[O:17][C:18]([F:19])([F:20])[F:21]>CCC(C)=O.I[Na]>[CH3:1][C:2](=[O:3])[NH:4][CH2:5][CH2:6][n:9]1[c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]2[s:16][c:8]1=[NH:7])[O:17][C:18]([F:19])([F:20])[F:21]|EP2222165B1_0663
1.7.13|[O&H0&+0&D1:7]=[c&H0&+0&D3:6](:[c:5]):[n&H1&+0&D2:4]:[c:3].[O:2]-[C&H2&+0&D2:1]-Cl>>[O&H0&+0&D2:7](-[C&H2&+0&D2:1]-[O:2])-[c&H0&+0&D3:6](:[c:5]):[n&H0&+0&D2:4]:[c:3]|[CH3:1][c:2]1[n:3][n:4]([c:5]2[nH:6][c:7]([c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[c:14]12)=[O:15])[CH3:16].[CH3:17][O:18][CH2:19]Cl>O.O.CS(C)=O.[NaH]>[CH3:17][O:18][CH2:19][O:15][c:7]1[n:6][c:5]2[c:14]([c:13]3[cH:12][cH:11][cH:10][cH:9][c:8]13)[c:2]([n:3][n:4]2[CH3:16])[CH3:1]|US09539252B2_1067
4.1.69|[N&H2&+0&D1:6]-[N&H1&+0&D2:5]-[c:4]:[n&H0&+0&D2:3]:[c:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:6]1:[n&H0&+0&D2:5]:[c:4]:[n&H0&+0&D3:3](:[c:2]):[c&H1&+0&D2:1]:1|[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([cH:7][c:8]1[O:9][CH3:10])[n:11][c:12]([n:13][c:14]2[NH:15][NH2:16])[Cl:17].CO[CH:18](OC)OC>Cc1ccc(cc1)S(=O)(=O)O>[CH3:10][O:9][c:8]1[cH:7][c:6]2[n:11][c:12]([n:13]3[cH:18][n:16][n:15][c:14]3[c:5]2[cH:4][c:3]1[O:2][CH3:1])[Cl:17]|US20200360353A1_1022
4.2.22|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[O&H1&+0&D1:4]-[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:6](-[C:5]):[o&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[n:1]|[CH:1]#[C:2][C@@H:3]1[CH2:4][CH2:5][CH2:6][N:7]1[C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14].[OH:15][c:16]1[cH:17][cH:18][cH:19][n:20][c:21]1I>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCN(CC)CC.Cc1ccccc1.CN(C)C=O.I[Cu]>[CH3:12][C:11]([CH3:13])([CH3:14])[O:10][C:8](=[O:9])[N:7]1[CH2:6][CH2:5][CH2:4][C@H:3]1[c:2]1[cH:1][c:21]2[n:20][cH:19][cH:18][cH:17][c:16]2[o:15]1|US20180057505A1_0634
3.9.1|[Br&H0&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-Br.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[Br&H0&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[C@@H:7]1[N:8]2[C:9]([C:10]([C@H:11]2[S:12][C:13]1([CH3:14])[CH3:15])([Br:16])Br)=[O:17].[O:18]=[CH:19][C:20](=[O:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>[NH4+].[Cl-].C[Mg]Br.O=CC=O.C1CCOC1>[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[C@@H:7]1[N:8]2[C:9]([C:10]([C@H:11]2[S:12][C:13]1([CH3:14])[CH3:15])([Br:16])[CH:19]([OH:18])[C:20](=[O:21])[c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1)=[O:17]|EP0201221B1_0064
1.2.14|[C:7]-[C&H1&+0&D3:6]1-[O&H0&+0&D2:5]-[C&H1&+0&D3:4]-1-[C:3].[C:2]-[N&H2&+0&D1:1]>>[C:7]-[C@&H1&+0&D3:6](-[O&H1&+0&D1:5])-[C@&H1&+0&D3:4](-[C:3])-[N&H1&+0&D2:1]-[C:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[CH2:8][CH:9]3[O:10][CH:11]3[CH2:12][c:13]12)[O:14][CH3:15].[CH3:16][CH:17]([CH3:18])[NH2:19]>CCO>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[CH2:8][C@H:9]([C@@H:11]([CH2:12][c:13]12)[NH:19][CH:17]([CH3:16])[CH3:18])[OH:10])[O:14][CH3:15]|US20170190713A1_0379
1.9.11|[O&H0&D1:7]=[C&H0&+0&D3:6](-[O:5])-Cl.[O:4]-[P&H0&+0&D3:3](-[O:2])-[O&H0&+0&D2:1]-C>>[O&H0&D1:7]=[C&H0&+0&D3:6](-[O:5])-[P&H0&+0&D4:3](-[O:4])(-[O:2])=[O&H0&+0&D1:1]|C[O:1][P:2]([O:3][CH3:4])[O:5][CH3:6].[CH3:7][O:8][C:9](=[O:10])Cl>>[CH3:6][O:5][P:2](=[O:1])([O:3][CH3:4])[C:9](=[O:10])[O:8][CH3:7]|US10374256B2_0200
5.5.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[O&H1&+0&D1:3]-[C:2]-[C&H2&+0&D2:1]-O>>[C:7]-[C&H0&+0&D4:6]1(-[O&H0&+0&D2:5]-[C&H2&+0&D2:1]-[C:2]-[O&H0&+0&D2:3]-1)-[c:4]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[C:7]([C:8]3([CH2:9][CH2:10][C:11]([CH2:12][CH2:13]3)=[O:14])[CH2:15][c:16]2[cH:17]1)=[O:18].[OH:19][CH2:20][CH2:21]O>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:16]([cH:17]1)[CH2:15][C:8]1([CH2:9][CH2:10][C:11]([CH2:12][CH2:13]1)=[O:14])[C:7]21[O:18][CH2:21][CH2:20][O:19]1|US20200299273A1_0399
3.7.3|[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[#12]-Cl.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:6]-[C&H1&+0&D3:5](-[C&H3&D1:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([n:7][c:8]([c:9]([c:10]1[CH2:11][CH:12]([CH3:13])[CH3:14])[CH:15]=[O:16])[C:17]([F:18])([F:19])[F:20])[CH:21]([F:22])[F:23].[CH3:24][CH:25]([CH3:26])[Mg]Cl>O=Cc1ccccn1.CCOCC.O.Cl>[CH3:13][CH:12]([CH3:14])[CH2:11][c:10]1[c:5]([c:6]([n:7][c:8]([c:9]1[CH:15]([OH:16])[CH:25]([CH3:24])[CH3:26])[C:17]([F:18])([F:19])[F:20])[CH:21]([F:22])[F:23])[C:3](=[O:4])[O:2][CH3:1]|US20200255407A1_1068
2.3.2|[C&H3&D1:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[S&H0&D1:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[S&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5]1=[CH:6][CH2:7][NH:8][CH2:9][CH2:10]1.[CH3:11][N:12]=[C:13]=[S:14]>C1CCOC1>[CH3:1][C:2]([CH3:3])([CH3:4])[C:5]1=[CH:6][CH2:7][N:8]([CH2:9][CH2:10]1)[C:13](=[S:14])[NH:12][CH3:11]|US20190337950A1_0455
1.2.14|[C:7]-[C@@&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:7]-[C@&H1&+0&D3:6](-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:3]):[n:1])-[O&H1&+0&D1:4]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]2[c:8]1[cH:9][cH:10][cH:11][cH:12]2)[CH2:13][O:14][C@H:15]1[CH2:16][N:17]([CH2:18][C@H:19]([C@@H:20]1[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[O:27][CH2:28][CH2:29][CH2:30][O:31][c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1[N+:38]([O-:39])=[O:40])[O:41][CH2:42][C@H:43]1[CH2:44][O:45]1)[C:46](=[O:47])[O:48][C:49]([CH3:50])([CH3:51])[CH3:52].[cH:53]1[n:54][cH:55][nH:56][n:57]1>CN(C)C=O.[NaH]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]2[c:8]1[cH:9][cH:10][cH:11][cH:12]2)[CH2:13][O:14][C@H:15]1[CH2:16][N:17]([CH2:18][C@H:19]([C@@H:20]1[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[O:27][CH2:28][CH2:29][CH2:30][O:31][c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1[N+:38]([O-:39])=[O:40])[O:41][CH2:42][C@H:43]([OH:45])[CH2:44][n:56]1[cH:55][n:54][cH:53][n:57]1)[C:46](=[O:47])[O:48][C:49]([CH3:50])([CH3:51])[CH3:52]|US20200317637A1_0762
2.3.1|[C&H3&D1:7]-[N&H1&+0&D2:6]-[c:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[c:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[Cl:17].[O:18]=[C:19]=[N:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>ClCCl>[CH3:1][N:2]([C:19](=[O:18])[NH:20][c:21]1[cH:26][cH:25][cH:24][cH:23][cH:22]1)[c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[Cl:17]|EP1781297B1_0133
4.1.13|[C:7]-[N&H1&+0&D2:6]-[N&H2&+0&D1:5].[n:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-Cl>>[C:7]-[n&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[c&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:3]:1:[n:4]|[NH2:1][NH:2][CH2:3][CH2:4][OH:5].[NH2:6][c:7]1[n:8][c:9]([c:10]([c:11]([n:12]1)Cl)[CH:13]=O)[NH:14][NH:15][C:16](=[O:17])[c:18]1[cH:19][cH:20][cH:21][o:22]1>>[NH2:6][c:7]1[n:8][c:9]([c:10]2[cH:13][n:1][n:2]([c:11]2[n:12]1)[CH2:3][CH2:4][OH:5])[NH:14][NH:15][C:16](=[O:17])[c:18]1[cH:19][cH:20][cH:21][o:22]1|US20190185479A1_1872
2.3.1|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][c:2]1[n:3][n:4][c:5]([s:6]1)[N:7]=[C:8]=[O:9].[CH3:10][NH:11][CH2:12][CH2:13][CH:14]=[O:15]>c1ccccc1>[CH3:1][c:2]1[n:3][n:4][c:5]([s:6]1)[NH:7][C:8](=[O:9])[N:11]([CH3:10])[CH2:12][CH2:13][CH:14]=[O:15]|US20190144416A1_0178
2.3.2|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][NH:2][CH:3]1[CH2:4][CH2:5][N:6]([CH2:7][CH2:8]1)[CH2:9][CH2:10][c:11]1[cH:12][nH:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]12.[S:20]=[C:21]=[N:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>c1ccccc1>[CH3:1][N:2]([C:21](=[S:20])[NH:22][c:23]1[cH:28][cH:27][cH:26][cH:25][cH:24]1)[CH:3]1[CH2:4][CH2:5][N:6]([CH2:7][CH2:8]1)[CH2:9][CH2:10][c:11]1[cH:12][nH:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21|US20140004243A1_0231
4.1.12|[C:7]-[C&H1&+0&D3:6](-[C&H1&+0&D2:5]=O)-Cl.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[n:1]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[n:1]|Cl.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][CH:10](Cl)[CH:11]=O.[NH2:12][c:13]1[n:14][n:15][c:16]([cH:17][n:18]1)-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25]>CCC(C)(C)O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][c:10]1[cH:11][n:12][c:13]2[n:18][cH:17][c:16]([n:15][n:14]12)-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25]|US09868742B2_0413
2.3.2|[C&H3&D1:7]-[N&H1&+0&D2:6]-[c:5].[C:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:2]=[S&H0&D1:1]>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[c:5])-[C&H0&+0&D3:2](=[S&H0&D1:1])-[N&H1&+0&D2:3]-[C:4]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[CH3:9][CH2:10][O:11][C:12](=[O:13])[N:14]1[CH2:15][CH2:16][CH:17]([CH2:18][CH2:19]1)[N:20]=[C:21]=[S:22]>Cc1ccccc1.CN(C)c1ccncc1>[CH3:9][CH2:10][O:11][C:12](=[O:13])[N:14]1[CH2:15][CH2:16][CH:17]([CH2:18][CH2:19]1)[NH:20][C:21](=[S:22])[N:2]([CH3:1])[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|EP1781297B1_0111
2.3.1|[C&H3&D1:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]=[C:3]=[O:4].[O:5]=[c:6]1[nH:7][c:8]([nH:9][cH:10][c:11]1[F:12])=[O:13]>CS(C)=O>[CH3:1][NH:2][C:3](=[O:4])[n:9]1[cH:10][c:11]([c:6]([nH:7][c:8]1=[O:13])=[O:5])[F:12]|EP1660484B1_0200
4.1.12|[C:7]-[C&H1&+0&D3:6](-[C&H1&+0&D2:5]=O)-Cl.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Cl)[CH:7]=O.[NH2:8][c:9]1[cH:10][cH:11][cH:12][c:13]([n:14]1)[NH2:15].[K]>CCO.CC(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:15][c:13]2[cH:12][cH:11][cH:10][c:9]([n:14]21)[NH2:8]|EP2914596B1_0249
4.1.12|[C:7]-[C&H1&+0&D3:6](-[C&H1&+0&D2:5]=O)-Br.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[CH:14](Br)[CH:15]=O.[NH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][n:22]1>CCO>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[c:14]1[cH:15][n:16][c:17]2[cH:18][cH:19][cH:20][cH:21][n:22]12|US20200295277A1_0212
2.3.2|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C:5].[C:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:2]=[S&H0&D1:1]>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:2](=[S&H0&D1:1])-[N&H1&+0&D2:3]-[C:4]|[CH3:1][NH:2][CH2:3][CH:4]([CH3:5])[CH3:6].[O:7]=[C:8]([N:9]=[C:10]=[S:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>ClC(Cl)Cl>[CH3:5][CH:4]([CH3:6])[CH2:3][N:2]([CH3:1])[C:10](=[S:11])[NH:9][C:8](=[O:7])[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US20090062251A1_0343
1.2.14|[C:7]-[C@&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:7]-[C@@&H1&+0&D3:6](-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:3]):[c:1])-[O&H1&+0&D1:4]|[O-:1][N+:2](=[O:3])[c:4]1[n:5][cH:6][cH:7][nH:8]1.[Cl:9][CH2:10][C@H:11]1[CH2:12][O:13]1>O=C(O[K])O[K]>[O-:1][N+:2](=[O:3])[c:4]1[n:5][cH:6][cH:7][n:8]1[CH2:12][C@@H:11]([OH:13])[CH2:10][Cl:9]|US09394317B2_0100
4.1.13|[C:7]-[N&H1&+0&D2:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-Cl>>[C:7]-[n&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[c&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:3]:1:[c:4]|Cl.[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][NH:7][NH2:8].[O:9]=[c:10]1[o:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[c:18]([c:19]1[CH:20]=O)Cl>CCO.CC(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][n:7]1[n:8][cH:20][c:19]2[c:10]([o:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[c:18]21)=[O:9]|US10538525B2_0313
1.2.14|[C:7]-[C@@&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:7]-[C@&H1&+0&D3:6](-[C&H2&+0&D2:5]-[N&H0&+0&D3:2](-[C:3])-[C:1])-[O&H1&+0&D1:4]|[CH3:1][C:2]([CH3:3])([CH3:4])[NH:5][C:6](=[O:7])[CH:8]1[CH2:9][CH:10]2[CH2:11][CH2:12][CH2:13][CH:14]2[NH:15]1.[O:16]=[C:17]([NH:18][C@@H:19]([CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[C@H:27]1[CH2:28][O:29]1)[O:30][CH2:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1>CCO>[CH3:1][C:2]([CH3:3])([CH3:4])[NH:5][C:6](=[O:7])[CH:8]1[CH2:9][CH:10]2[CH2:11][CH2:12][CH2:13][CH:14]2[N:15]1[CH2:28][C@@H:27]([OH:29])[C@H:19]([CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)[NH:18][C:17](=[O:16])[O:30][CH2:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1|EP2809671B1_0152
2.3.1|[C&H3&D1:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[Cl:12])[Cl:13].[CH3:14][N:15]=[C:16]=[O:17]>CC(C)OC(C)C.CCN(CC)CC>[CH3:14][NH:15][C:16](=[O:17])[N:5]([CH2:4][CH2:3][CH2:2][CH3:1])[c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[Cl:12])[Cl:13]|US20070060573A1_1015
1.7.17|[C:7]-[C&H1&+0&D3:6]1-[O&H0&+0&D2:5]-[C&H1&+0&D3:4]-1-[c:3].[O&H1&+0&D1:2]-[c:1]>>[C:7]-[C@@&H1&+0&D3:6](-[O&H1&+0&D1:5])-[C@&H1&+0&D3:4](-[O&H0&+0&D2:2]-[c:1])-[c:3]|[F:1][CH2:2][C:3]1([O:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[CH:11]2[O:12][CH:13]21)[C:14]([F:15])([F:16])[C:17]([F:18])([F:19])[F:20])[CH2:21][F:22].[OH:23][c:24]1[cH:25][cH:26][cH:27][cH:28][n:29]1>c1ccncc1.CCO>[OH:12][C@H:13]1[C@@H:11]([c:10]2[cH:9][c:8]([cH:7][cH:6][c:5]2[O:4][C:3]1([CH2:21][F:22])[CH2:2][F:1])[C:14]([F:15])([F:16])[C:17]([F:18])([F:19])[F:20])[O:23][c:24]1[cH:25][cH:26][cH:27][cH:28][n:29]1|US07326718B2_0212
2.8.5|[O&H1&+0&D1:7]-[C&H0&+0&D3:6](=[S&H0&+0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[O&H0&+0&D1:7]=[C&H0&+0&D3:6](-[S&H0&+0&D2:5]-[c&H0&+0&D3:2](:[c:3]):[c:1])-[c:4]|[F:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[n:8]1[n:9][cH:10][c:11]2[cH:12][c:13]([cH:14][cH:15][c:16]21)I.[OH:17][C:18](=[S:19])[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>Cc1c(cnc2c3ncc(c(c3ccc21)C)C)C.Cc1ccccc1.CC(C)NC(C)C.CCOC(C)=O.[Cu+].[I+]>[O:17]=[C:18]([S:19][c:13]1[cH:14][cH:15][c:16]2[c:11]([cH:10][n:9][n:8]2-[c:5]2[cH:4][cH:3][c:2]([cH:7][cH:6]2)[F:1])[cH:12]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US20180022696A1_0069
4.2.22|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[O&H1&+0&D1:4]-[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:6](-[C:5]):[o&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[n:1]|[CH:1]#[C:2][C:3]1([CH2:4][CH2:5][c:6]2[c:7]([c:8]([c:9]([c:10]([c:11]2[O:12]1)[CH3:13])[CH3:14])[OH:15])[CH3:16])[CH3:17].[OH:18][c:19]1[cH:20][cH:21][cH:22][n:23][c:24]1Br>CCN(CC)CC>[CH3:13][c:10]1[c:11]2[O:12][C:3]([CH2:4][CH2:5][c:6]2[c:7]([c:8]([c:9]1[CH3:14])[OH:15])[CH3:16])([CH3:17])[c:2]1[cH:1][c:24]2[n:23][cH:22][cH:21][cH:20][c:19]2[o:18]1|US05015661A
2.3.1|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C:5].[C:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:2]=[O&H0&D1:1]>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:2](=[O&H0&D1:1])-[N&H1&+0&D2:3]-[C:4]|[CH3:1][NH:2][CH:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[O:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21.[CH3:17][CH2:18][N:19]=[C:20]=[O:21]>ClCCl>[CH3:17][CH2:18][NH:19][C:20](=[O:21])[N:2]([CH3:1])[CH:3]1[c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[O:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]21|US20090124598A1_0915
2.3.1|[C&H3&D1:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[c:2]1[nH:3][nH:4][c:5]([n:6]1-[c:7]1[cH:8][c:9]([cH:10][c:11]([cH:12]1)[Cl:13])[Cl:14])=[O:15].[CH3:16][N:17]=[C:18]=[O:19]>CCN(CC)CC.CN(C)C=O.O>[CH3:16][NH:17][C:18](=[O:19])[n:4]1[nH:3][c:2]([n:6]([c:5]1=[O:15])-[c:7]1[cH:12][c:11]([cH:10][c:9]([cH:8]1)[Cl:14])[Cl:13])=[O:1]|US07700786B2_0419
2.3.1|[C&H3&D1:7]-[N&H0&+0&D2:6]=[C&H0&+0&D2:5]=[O&H0&D1:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][N:2]1[C:3]([CH2:4][C:5]([NH:6][CH2:7][C:8]1([CH3:9])[CH3:10])=[O:11])([CH3:12])[CH3:13].[CH3:14][N:15]=[C:16]=[O:17]>>[CH3:14][NH:15][C:16](=[O:17])[N:6]1[CH2:7][C:8]([N:2]([C:3]([CH2:4][C:5]1=[O:11])([CH3:12])[CH3:13])[CH3:1])([CH3:9])[CH3:10]|US20200109148A1_0709
2.3.1|[C&H3&D1:7]-[N&H1&+0&D2:6]-[c:5].[C:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:2]=[O&H0&D1:1]>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[c:5])-[C&H0&+0&D3:2](=[O&H0&D1:1])-[N&H1&+0&D2:3]-[C:4]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]12.[O:13]=[C:14]=[N:15][CH2:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][n:23]1>C1CCOC1>[CH3:1][N:2]([C:14](=[O:13])[NH:15][CH2:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][n:23]1)[c:3]1[cH:4][cH:5][cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21|US20090176786A1_0817
4.2.22|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[O&H1&+0&D1:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:6](-[C:5]):[o&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1]|[OH:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[OH:8])Br.[CH:9]#[C:10][CH2:11][CH2:12][OH:13]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCN(CC)CC.Cl[Pd]Cl.[I-].[I-].[Cu+2]>[OH:13][CH2:12][CH2:11][c:10]1[cH:9][c:6]2[cH:5][cH:4][cH:3][c:2]([c:7]2[o:8]1)[OH:1]|EP3421458A1_0341
4.2.11|[C:7]-[C&H0&+0&D3:6](=[N&H0&+0&D2:5]-[O&H1&+0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[o&H0&+0&D2:4]:[c&H0&+0&D3:2](:[c:1]):[c:3]:1|Cl.[OH:1][N:2]=[C:3]([c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1F)[F:10])[CH:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1>O.O[K]>[F:10][c:7]1[cH:6][cH:5][c:4]2[c:3]([n:2][o:1][c:9]2[cH:8]1)[CH:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1|EP3344604B1_0467
4.2.11|[C:7]-[C&H0&+0&D3:6](=[N&H0&+0&D2:5]-[O&H1&+0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[o&H0&+0&D2:4]:[c&H0&+0&D3:2](:[c:1]):[c:3]:1|[CH3:1][CH2:2][CH2:3][c:4]1[c:5]([c:6]([cH:7][c:8]([c:9]1O)[C:10](=[N:11][OH:12])[C:13]([F:14])([F:15])[F:16])[CH2:17][CH2:18][CH3:19])[OH:20]>CCN(CC)CC.CC(=O)OC(C)=O.c1ccncc1>[CH3:1][CH2:2][CH2:3][c:4]1[c:5]([c:6]([cH:7][c:8]2[c:10]([n:11][o:12][c:9]12)[C:13]([F:14])([F:15])[F:16])[CH2:17][CH2:18][CH3:19])[OH:20]|US07176242B2_2275
4.1.90|[N&H2&+0&D1:6]-[c:5]:[n&H0&+0&D2:4]:[c:3].[C&H1&+0&D3:2](-[N&H0&+0&D3:1](-C)-C)(-O-C)-O-C>>[n&H0&+0&D2:6]1:[c:5]:[n&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:1]:[c&H1&+0&D2:2]:1|CO[CH:1](OC)[N:2](C)C.[NH2:3][c:4]1[cH:5][c:6]([cH:7][cH:8][n:9]1)[I:10]>CO.CN(C)C=O.NOS(=O)(=O)O.c1ccncc1>[I:10][c:6]1[cH:7][cH:8][n:9]2[n:2][cH:1][n:3][c:4]2[cH:5]1|US20200131180A1_0302
2.3.10|[C&H3&D1:6]-[N&H1&+0&D2:5]-[C&H3&D1:4].[N:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-c1:c:c:c:c:c:1>>[C&H3&D1:6]-[N&H0&+0&D3:5](-[C&H3&D1:4])-[C&H0&+0&D3:2](-[N:3])=[O&H0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][s:9][c:10]1[NH:11][C:12](=[O:13])Oc1ccccc1)[O:14][CH2:15][CH3:16].[CH3:17][NH:18][CH3:19]>CN(C)C=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:8][s:9][c:10]1[NH:11][C:12](=[O:13])[N:18]([CH3:17])[CH3:19])[O:14][CH2:15][CH3:16]|US09290459B1_0419
1.2.14|[C:7]-[N&H1&+0&D2:6]-[C:5].[c:4]-[C@@&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[C&H2&+0&D2:2]-[C@@&H1&+0&D3:3](-[c:4])-[O&H1&+0&D1:1]|[NH2:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])[O:11][CH2:12][CH2:13][NH:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[cH:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[C@@H:28]1[CH2:29][O:30]1>CC(C)O>[NH2:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])[O:11][CH2:12][CH2:13][N:14]([CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[CH2:29][C@H:28]([OH:30])[c:25]1[cH:26][cH:27][cH:22][cH:23][cH:24]1|US09751881B2_0628
4.1.34|[C&H3&+0&D1:7]-[C&H0&+0&D3:6](-[C:5])=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:6]:1-[C:5]|Cl.Cl.[CH3:1][C:2](=O)[CH:3]1[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1.N[NH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[Cl:16]>CCO.c1ccncc1>[Cl:16][c:13]1[cH:14][cH:15][c:10]2[nH:9][c:2]([cH:1][c:11]2[cH:12]1)[CH:3]1[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1|US20100087446A1_0181
4.2.11|[N:7]-[C&H0&+0&D3:6](=[N&H0&+0&D2:5]-[O&H1&+0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[N:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[o&H0&+0&D2:4]:[c&H0&+0&D3:2](:[c:1]):[c:3]:1|[CH3:1][c:2]1[n:3][c:4]2[S:5][CH2:6][CH2:7][n:8]2[c:9]([c:10]1[CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][N:16]([CH2:17][CH2:18]1)[C:19](=[N:20][OH:21])[c:22]1[cH:23][cH:24][c:25]([cH:26][c:27]1F)[F:28])=[O:29]>[NH4+].CCO.CC(=O)O.Cc1ccccc1.C1CCOC1.[OH-].[NaH]>[CH3:1][c:2]1[n:3][c:4]2[S:5][CH2:6][CH2:7][n:8]2[c:9]([c:10]1[CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][N:16]([CH2:17][CH2:18]1)[c:19]1[n:20][o:21][c:27]2[cH:26][c:25]([cH:24][cH:23][c:22]12)[F:28])=[O:29]|US09556135B2_1172
4.3.6|[C:7]-[C&H2&+0&D2:6]-[S&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-F>>[C:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:5]:[c&H0&+0&D3:3](:[c:4]):[c:2]:[c&H1&+0&D2:1]:1|[CH3:1][O:2][C:3](=[O:4])[CH2:5][SH:6].O=[CH:7][c:8]1[c:9]([cH:10][cH:11][cH:12][c:13]1F)[CH:14]1[O:15][CH2:16][CH2:17][O:18]1>O.O.[Na+].CCCCCC.CS(C)=O.[H-]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:7][c:8]2[c:9]([cH:10][cH:11][cH:12][c:13]2[s:6]1)[CH:14]1[O:15][CH2:16][CH2:17][O:18]1|US20200024226A1_1463
4.2.32|[C:7]-[C&H1&+0&D3:6](-[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1])-O>>[C:7]-[C&H1&+0&D3:6]1-[O&H0&+0&D2:2]-[C&H0&+0&D3:3](-[c:1])=[N&H0&+0&D2:4]-[C:5]-1|[CH3:1][CH2:2][CH:3](O)[CH2:4][NH:5][C:6](=[O:7])[c:8]1[cH:9][n:10][c:11]([c:12]([cH:13]1)[Cl:14])[Cl:15]>ClCCl>[CH3:1][CH2:2][CH:3]1[CH2:4][N:5]=[C:6]([O:7]1)[c:8]1[cH:9][n:10][c:11]([c:12]([cH:13]1)[Cl:14])[Cl:15]|US08017610B2_0943
4.1.3|[N&H2&+0&D1:7]-[c:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C:2]-[C&H2&+0&D2:1]-O-C)-O-C-C>>[N&H0&+0&D3:7]1(-[c:6])-[C&H2&+0&D2:1]-[C:2]-[C:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|CO[CH2:1][CH2:2][C:3]1([CH2:4][CH2:5][N:6]([CH2:7][CH2:8]1)[S:9](=[O:10])(=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18])[C:19](=[O:20])OCC.[NH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[O:28][C:29]([F:30])([F:31])[F:32]>CCCCCCC.Cc1ccccc1.C[Al](C)Cl.O>[O:10]=[S:9](=[O:11])([c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18])[N:6]1[CH2:5][CH2:4][C:3]2([CH2:8][CH2:7]1)[CH2:2][CH2:1][N:21]([C:19]2=[O:20])[c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[O:28][C:29]([F:30])([F:31])[F:32]|EP2430023B1_0329
3.11.24|[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[O&H0&+0&D2:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[c&H0&+0&D3:2](:[c:1]):[c:3]-[O&H1&+0&D1:4]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[Cl:8])[O:9][C:10]([CH3:11])=[O:12]>O.Cl.Cl[Al](Cl)Cl>[CH3:11][C:10](=[O:12])[c:5]1[cH:6][c:7]([c:2]([cH:3][c:4]1[OH:9])[CH3:1])[Cl:8]|US20120083501A1_0474
8.8.18|[O&H0&D1:8]=[C&H0&+0&D3:7]1-[c:6]:[c:5]-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1>>[O&H0&D1:8]=[c&H0&+0&D3:7]1:[c:6]:[c:5]:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1|[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]2[C:7]([c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[CH2:14][CH2:15][c:16]2[cH:17]1)=[O:18]>Cc1ccc2C(c3ccccc3CCc2c1)=O.Cc1ccc2c(ccc3ccccc3c2=O)c1.O=C1CCC(N1Br)=O.ClC(Cl)(Cl)Cl>[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]2[c:16]([cH:15][cH:14][c:13]3[cH:12][cH:11][cH:10][cH:9][c:8]3[c:7]2=[O:18])[cH:17]1|US20050107608A1_0470
2.2.3|[O&H0&D1:6]=[S&H0&+0&D4:5](=[O&H0&D1:4])(-[c:3])-Cl.[c:2]-[N&H1&+0&D2:1]-S(=O)(=O)-c1:c:c:c:c:c:1>>[O&H0&D1:6]=[S&H0&+0&D4:5](=[O&H0&D1:4])(-[c:3])-[N&H1&+0&D2:1]-[c:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([s:8][c:9]2[CH2:10][CH2:11][CH2:12][CH2:13][c:14]21)[NH:15]S(=O)(=O)c1ccccc1.[CH3:16][O:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[S:24](=[O:25])(=[O:26])Cl>>[CH3:16][O:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[S:24](=[O:25])(=[O:26])[NH:15][c:7]1[s:8][c:9]2[CH2:10][CH2:11][CH2:12][CH2:13][c:14]2[c:6]1[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20130158075A1_1947
1.3.7|[C:7]-[C&H0&+0&D3:6](=[N&H0&+0&D2:5]-[N&H2&+0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[n&H1&+0&D2:4]:[c&H0&+0&D3:2](:[c:1]):[c:3]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[C:16]12[CH2:17][CH2:18][C:19]([CH2:20][CH2:21]1)([CH2:22][CH2:23]2)[C:24](=[N:25][NH2:26])[c:27]1[c:28]2[cH:29][cH:30][nH:31][c:32]2[n:33][cH:34][c:35]1Cl>>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[C:16]12[CH2:17][CH2:18][C:19]([CH2:20][CH2:21]1)([CH2:22][CH2:23]2)[c:24]1[n:25][nH:26][c:35]2[cH:34][n:33][c:32]3[nH:31][cH:30][cH:29][c:28]3[c:27]21|US09365579B2_1265
4.1.12|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Br)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[c:1]):[c&H1&+0&D2:5]:1|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][n:7]1.O=[C:8]([CH2:9][CH2:10][N:11]1[C:12]([c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[C:19]1=[O:20])=[O:21])[CH2:22]Br>O.CCO.CN(C)C=O.O=C(O)O[Na]>[O:21]=[C:12]1[c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[C:19]([N:11]1[CH2:10][CH2:9][c:8]1[cH:22][n:7]2[cH:6][cH:5][cH:4][cH:3][c:2]2[n:1]1)=[O:20]|US09695180B2_0356
4.1.12|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Cl)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[n:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[n:1]):[c&H1&+0&D2:5]:1|[CH3:1][O:2][C:3](=[O:4])[CH2:5][C:6](=O)[CH2:7]Cl.[NH2:8][c:9]1[cH:10][cH:11][c:12]([n:13][n:14]1)[Cl:15]>CO>[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[cH:7][n:14]2[n:13][c:12]([cH:11][cH:10][c:9]2[n:8]1)[Cl:15]|US20190284182A1_1375
4.1.12|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Br)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[n:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[n:1]):[c&H1&+0&D2:5]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])[C:9](=O)[CH2:10]Br.[NH2:11][c:12]1[cH:13][cH:14][c:15]([n:16][n:17]1)[Cl:18]>O.[Na+].[Na+].CCO.[O-]P([O-])(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([CH3:7])([CH3:8])[c:9]1[cH:10][n:17]2[n:16][c:15]([cH:14][cH:13][c:12]2[n:11]1)[Cl:18]|US20190284182A1_1829
4.3.6|[C:7]-[C&H2&+0&D2:6]-[S&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-Br>>[C:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:5]:[c&H0&+0&D3:3](:[c:4]):[c:2]:[c&H1&+0&D2:1]:1|[CH3:1][O:2][C:3](=[O:4])[CH2:5][SH:6].O=[CH:7][c:8]1[cH:9][c:10]2[O:11][CH2:12][O:13][c:14]2[cH:15][c:16]1Br>[NaH]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:7][c:8]2[cH:9][c:10]3[O:11][CH2:12][O:13][c:14]3[cH:15][c:16]2[s:6]1|US20180170909A1_2529
10.3.1|[O&H0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[O&H1&D1:4])-O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&D1:7]=[S&H0&+0&D4:6](=[O&H0&D1:5])(-[O&H1&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[S:2](=[O:3])(O)[OH:4].[OH:5][c:6]1[cH:7][cH:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[cH:15]1>[Na+].[O-]S(=O)(=O)c1ccc2cc(ccc2c1)O>[O:1]=[S:2](=[O:3])([OH:4])[c:11]1[cH:12][cH:13][c:14]2[cH:15][c:6]([cH:7][cH:8][c:9]2[cH:10]1)[OH:5]|US09556195B2_0321
4.1.12|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Cl)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[c:1]):[c&H1&+0&D2:5]:1|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][n:7]1.O=[C:8]([CH2:9]Cl)[CH2:10][Cl:11]>CCO>[Cl:11][CH2:10][c:8]1[cH:9][n:7]2[cH:6][cH:5][cH:4][cH:3][c:2]2[n:1]1|US20200317667A1_0402
1.8.17|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H3&D1:5])=[C&H1&+0&D2:4]-[C:3].[C:2]-[S&H1&+0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[S&H0&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[C:3]|[CH3:1][C:2]([CH3:3])=[CH:4][C:5](=[O:6])[OH:7].[SH:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>C1CCNCC1>[CH3:1][C:2]([CH3:3])([CH2:4][C:5](=[O:6])[OH:7])[S:8][CH2:9][c:10]1[cH:15][cH:14][cH:13][cH:12][cH:11]1|EP3533786A1_0080
2.2.3|[F&H0&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-F.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[F&H0&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[n:5][cH:6][cH:7][nH:8]1.[O:9]=[S:10](=[O:11])([F:12])F>CC#N.O=C(O[Na])O[Na]>[CH3:1][CH:2]([CH3:3])[c:4]1[n:5][cH:6][cH:7][n:8]1[S:10](=[O:9])(=[O:11])[F:12]|
4.3.6|[C:7]-[C&H2&+0&D2:6]-[S&H1&+0&D1:5].[n:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-Cl>>[C:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:5]:[c&H0&+0&D3:3](:[n:4]):[c:2]:[c&H1&+0&D2:1]:1|[CH3:1][n:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[c:9]([c:10]1Cl)[CH:11]=O.[CH3:12][O:13][C:14](=[O:15])[CH2:16][SH:17]>[O-]C([O-])=O.[K+].[K+]>[CH3:12][O:13][C:14](=[O:15])[c:16]1[cH:11][c:9]2[c:8]3[cH:7][cH:6][cH:5][cH:4][c:3]3[n:2]([c:10]2[s:17]1)[CH3:1]|US20090182140A1_0287
4.2.16|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[N&H1&+0&D2:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:5]:[c&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:1|[CH3:1][N:2]1[C:3]([NH:4][C:5]([C@@:6]11[CH2:7][c:8]2[cH:9][c:10]([c:11]([cH:12][c:13]2[CH2:14]1)Br)[NH:15][C:16](=[O:17])[CH2:18][n:19]1[c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[n:26]([c:27]1=[O:28])-[c:29]1[cH:30][cH:31][cH:32][cH:33][n:34]1)=[O:35])=[O:36]>CN(C)C=O.[O-]C([O-])=O.Br[Cu].c1ccncc1.[K+].[K+]>[CH3:1][N:2]1[C:3]([NH:4][C:5]([C@:6]11[CH2:14][c:13]2[cH:12][c:11]3[o:17][c:16]([n:15][c:10]3[cH:9][c:8]2[CH2:7]1)[CH2:18][n:19]1[c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[n:26]([c:27]1=[O:28])-[c:29]1[cH:30][cH:31][cH:32][cH:33][n:34]1)=[O:35])=[O:36]|US20130085150A1_0380
1.7.12|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H3&D1:5])=[C&H1&+0&D2:4]-[C:3].[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[O&H0&+0&D2:1]-[C:2])-[C&H2&+0&D2:4]-[C:3]|[CH3:1][CH2:2][OH:3].[CH3:4][CH2:5][O:6][C:7](=[O:8])[CH:9]=[C:10]([CH3:11])/[CH:12]=[CH:13]/[CH2:14][CH:15]([CH3:16])[CH2:17][CH2:18][CH:19]=[C:20]([CH3:21])[CH3:22]>[Na+].CC([O-])=O.CC([O-])=O.O[K].[BH4-].[Hg+2]>[CH3:4][CH2:5][O:6][C:7](=[O:8])[CH:9]=[C:10]([CH3:11])/[CH:12]=[CH:13]/[CH2:14][CH:15]([CH3:16])[CH2:17][CH2:18][CH2:19][C:20]([CH3:21])([CH3:22])[O:3][CH2:2][CH3:1]|US20130109682A1_1006
3.11.24|[O&H0&D1:8]=[C&H0&+0&D3:7]1-[C:6]-[C:5]-[N&H0&+0&D3:4]-1-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&D1:8]=[C&H0&+0&D3:7]1-[C:6]-[C:5]-[N&H1&+0&D2:4]-[c:3]:[c&H0&+0&D3:2]-1:[c:1]|[CH3:1][C:2]1([CH2:3][N:4]([C:5]1=[O:6])[c:7]1[cH:8][c:9]([cH:10][cH:11][cH:12]1)[C:13]([F:14])([F:15])[F:16])[CH3:17]>O=P(O)(O)O.O>[CH3:1][C:2]1([CH2:3][NH:4][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[C:5]1=[O:6])[C:13]([F:14])([F:15])[F:16])[CH3:17]|EP2914594B1_0440
4.3.6|[C:7]-[C&H2&+0&D2:6]-[S&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-Cl>>[C:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:5]:[c&H0&+0&D3:3](:[c:4]):[c:2]:[c&H1&+0&D2:1]:1|[CH3:1][C:2](=[O:3])[CH2:4][SH:5].[N:6]#[C:7][c:8]1[c:9]([s:10][c:11]([c:12]1Cl)[CH:13]=O)[NH2:14]>CN(C)C=O.O=C(O[K])O[K]>[CH3:1][C:2](=[O:3])[c:4]1[cH:13][c:11]2[s:10][c:9]([c:8]([c:12]2[s:5]1)[C:7]#[N:6])[NH2:14]|US20190194198A1_0366
3.10.2|[F&H0&D1:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-I.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[F&H0&D1:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[c:2]1[cH:3][cH:4][nH:5][c:6]([nH:7]1)=[O:8].[F:9][C:10]([F:11])([F:12])I>[O-]S([O-])(=O)=O.CS(C)=O.OO.[Fe+2]>[O:8]=[c:6]1[nH:5][cH:4][c:3]([c:2]([nH:7]1)=[O:1])[C:10]([F:9])([F:11])[F:12]|EP1947092B1_0194
3.10.2|[F&H0&D1:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-I.[n:3]:[c&H1&+0&D2:2]:[n:1]>>[F&H0&D1:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[c&H0&+0&D3:2](:[n:3]):[n:1]|[NH2:1][c:2]1[n:3][cH:4][n:5][c:6]2[n:7][cH:8][nH:9][c:10]12.[F:11][C:12]([F:13])([F:14])I>[O-]S([O-])(=O)=O.O=S(=O)(O)O.CS(C)=O.OO.[Fe+2]>[NH2:1][c:2]1[n:3][cH:4][n:5][c:6]2[n:7][c:8]([nH:9][c:10]12)[C:12]([F:11])([F:13])[F:14]|EP1947092B1_0233
4.1.60|[C:7]-[C&H0&+0&D3:6](-[c:5]:[c&H0&+0&D3:4](:[c:3])-O)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](:[c:3]):[c:5]:1|O.[NH2:1][NH2:2].[O:3]=[c:4]1[c:5]([c:6]([c:7]2[cH:8][cH:9][cH:10][n:11][c:12]2[n:13]1-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)O)[C:20](=O)[CH2:21][CH2:22][c:23]1[cH:24][cH:25][n:26][cH:27][cH:28]1>CCO>[O:3]=[c:4]1[c:5]2[c:20]([n:1][nH:2][c:6]2[c:7]2[cH:8][cH:9][cH:10][n:11][c:12]2[n:13]1-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[CH2:21][CH2:22][c:23]1[cH:24][cH:25][n:26][cH:27][cH:28]1|EP1559716B1_0145
2.2.3|[C&H3&D1:7]-[N&H1&+0&D2:6]-[c:5].[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[c:5])-[S&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)/[CH:9]=[CH:10]/[S:11](=[O:12])(=[O:13])Cl.[CH3:14][NH:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>>[CH3:1][O:2][c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)/[CH:9]=[CH:10]/[S:11](=[O:12])(=[O:13])[N:15]([CH3:14])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20190241559A1_0893
4.1.45|[C&H3&D1:7]-[C&H0&+0&D4:6](-O-C)(-O-C)-O-C.[C:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D3:4]:1-[C:5]|[NH2:1][c:2]1[n:3][c:4]([c:5]([c:6]([n:7]1)[NH:8][C@H:9]1[CH:10]=[CH:11][C@H:12]([CH2:13]1)[CH2:14][OH:15])[NH2:16])[Cl:17].CO[C:18]([CH3:19])(OC)OC>CCS(=O)(=O)O.CN(C)C=O>[CH3:19][c:18]1[n:16][c:5]2[c:4]([n:3][c:2]([n:7][c:6]2[n:8]1[C@H:9]1[CH:10]=[CH:11][C@H:12]([CH2:13]1)[CH2:14][OH:15])[NH2:1])[Cl:17]|US20190330196A1_1058
4.2.22|[#14:7]-[C&H0&+0&D2:6]#[C&H1&+0&D1:5].[O&H1&+0&D1:4]-[c:3]:[c&H0&+0&D3:2](:[n:1])-I>>[#14:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c&H0&+0&D3:2](:[n:1]):[c:3]:[o&H0&+0&D2:4]:1|[CH:1]#[C:2][Si:3]([CH3:4])([CH3:5])[CH3:6].[OH:7][c:8]1[cH:9][c:10]([cH:11][n:12][c:13]1I)[Br:14]>>[CH3:4][Si:3]([CH3:5])([CH3:6])[c:2]1[cH:1][c:13]2[n:12][cH:11][c:10]([cH:9][c:8]2[o:7]1)[Br:14]|EP3643718A1_0379
2.2.3|[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[c:1]|[CH3:1][S:2](=[O:3])(=[O:4])Cl.[CH3:5][S:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[NH:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[N+:21]([O-:22])=[O:23]>>[CH3:5][S:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[N:13]([CH2:14][c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[N+:21]([O-:22])=[O:23])[S:2]([CH3:1])(=[O:3])=[O:4]|US20190322662A1_0532
4.1.24|[C:6]-[C&H0&+0&D2:5]#[N&H0&+0&D1:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#11]>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:1|[N-:1]=[N+:2]=[N:3][Na].[N:4]#[C:5][CH2:6][O:7][c:8]1[cH:9][c:10]2[CH2:11][C:12]3([CH2:13][CH2:14][CH2:15][CH2:16]3)[C:17]([c:18]2[c:19]([c:20]1[Cl:21])[Cl:22])=[O:23]>[NH4+].[Cl-].CN(C)C=O>[O:23]=[C:17]1[c:18]2[c:10]([cH:9][c:8]([c:20]([c:19]2[Cl:22])[Cl:21])[O:7][CH2:6][c:5]2[n:4][n:1][n:2][nH:3]2)[CH2:11][C:12]11[CH2:13][CH2:14][CH2:15][CH2:16]1|US20100210635A1_0810
2.2.3|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][NH:2][c:3]1[n:4][n:5][c:6]([s:7]1)[S:8](=[O:9])(=[O:10])Cl.[CH3:11][NH:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][o:18]1>CCN(CC)CC.C1CCOC1.O>[CH3:1][NH:2][c:3]1[n:4][n:5][c:6]([s:7]1)[S:8](=[O:9])(=[O:10])[N:12]([CH3:11])[CH2:13][c:14]1[cH:15][cH:16][cH:17][o:18]1|EP3597653A1_0351
4.1.13|[C:7]-[C&H0&+0&D3:6](-[c:5]:[c&H0&+0&D3:4](:[c:3])-F)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](:[c:3]):[c:5]:1|O.[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[C:8](=O)[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1F.[NH2:15][NH2:16]>O>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[c:8]1[n:15][nH:16][c:14]2[cH:13][cH:12][cH:11][cH:10][c:9]12|EP3204360B1_0229
4.2.16|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[N&H1&+0&D2:3]-[C&H2&+0&D2:2]-[C&H1&+0&D2:1]=O>>[C:6]-[c&H0&+0&D3:5]1:[o&H0&+0&D2:4]:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[n&H0&+0&D2:3]:1|[CH3:1][C:2]([CH3:3])([F:4])[CH2:5][CH2:6][CH:7]([CH2:8][CH:9]([O:10][Si:11]([CH3:12])([CH3:13])[C:14]([CH3:15])([CH3:16])[CH3:17])[CH:18]([CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[NH:26][C:27](=[O:28])[c:29]1[cH:30][n:31][c:32]2[cH:33][cH:34][cH:35][cH:36][c:37]2[n:38]1)[C:39](=[O:40])[NH:41][CH2:42][CH:43]=O>c1ccc(cc1)P(c1ccccc1)c1ccccc1.ClC(Cl)(Cl)C(Cl)(Cl)Cl.CCN(CC)CC.ClCCl>[CH3:15][C:14]([CH3:16])([CH3:17])[Si:11]([CH3:12])([CH3:13])[O:10][CH:9]([CH2:8][CH:7]([CH2:6][CH2:5][C:2]([CH3:1])([CH3:3])[F:4])[c:39]1[n:41][cH:42][cH:43][o:40]1)[CH:18]([CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[NH:26][C:27](=[O:28])[c:29]1[cH:30][n:31][c:32]2[cH:33][cH:34][cH:35][cH:36][c:37]2[n:38]1|US20200299273A1_0380
2.2.3|[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH3:1][S:2](=[O:3])(=[O:4])Cl.[O:5]=[C:6]1[NH:7][CH2:8][CH2:9][CH2:10][NH:11]1>C[Si](C)(C)Cl>[CH3:1][S:2](=[O:3])(=[O:4])[N:11]1[CH2:10][CH2:9][CH2:8][NH:7][C:6]1=[O:5]|EP3527570A1_0324
2.2.3|[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[c:2]1[c:3]([cH:4][nH:5][n:6]1-[c:7]1[cH:8][cH:9][cH:10][cH:11][n:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[CH3:19][S:20](=[O:21])(=[O:22])Cl>CCN(CC)CC.C1COCCO1.O>[CH3:19][S:20](=[O:21])(=[O:22])[n:5]1[cH:4][c:3]([c:2]([n:6]1-[c:7]1[cH:8][cH:9][cH:10][cH:11][n:12]1)=[O:1])-[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|EP3204360B1_0624
4.2.3|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[N&H1&+0&D2:3]-[N&H1&+0&D2:2]-[C&H1&+0&D2:1]=O>>[C:6]-[c&H0&+0&D3:5]1:[o&H0&+0&D2:4]:[c&H1&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D2:3]:1|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)-[c:8]1[cH:9][n:10][c:11]([s:12]1)[CH2:13][C:14]([CH3:15])([CH3:16])[C:17](=[O:18])[NH:19][NH:20][CH:21]=O)[NH:22][c:23]1[n:24][cH:25][cH:26][c:27]([n:28]1)[C:29]([F:30])([F:31])[F:32]>CC[N+](CC)(CC)S(=O)(=O)N=C([O-])OC.C1CCOC1>[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)-[c:8]1[cH:9][n:10][c:11]([s:12]1)[CH2:13][C:14]([CH3:15])([CH3:16])[c:17]1[n:19][n:20][cH:21][o:18]1)[NH:22][c:23]1[n:24][cH:25][cH:26][c:27]([n:28]1)[C:29]([F:30])([F:31])[F:32]|US20200071301A1_1782
2.2.3|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C:5].[N:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](-[N:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])Cl.[CH3:7][NH:8][CH:9]1[CH2:10][CH2:11][N:12]([CH2:13]1)[C:14](=[O:15])[c:16]1[cH:17][c:18]2[n:19][cH:20][cH:21][c:22]([c:23]2[s:24]1)[Cl:25]>>[CH3:1][N:2]([CH3:3])[S:4](=[O:5])(=[O:6])[N:8]([CH3:7])[CH:9]1[CH2:10][CH2:11][N:12]([CH2:13]1)[C:14](=[O:15])[c:16]1[cH:17][c:18]2[n:19][cH:20][cH:21][c:22]([c:23]2[s:24]1)[Cl:25]|EP0897923A1_0061
2.2.3|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C:5].[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][NH:2][CH2:3][CH2:4][c:5]1[cH:6][cH:7][n:8][cH:9][cH:10]1.[O:11]=[S:12](=[O:13])(Cl)[CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1>O.O.CCO.CN(C)C=O.[NaH]>[CH3:1][N:2]([CH2:3][CH2:4][c:5]1[cH:6][cH:7][n:8][cH:9][cH:10]1)[S:12](=[O:11])(=[O:13])[CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1|US20200385345A1_0949
3.7.2|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]([CH3:8])=[O:9].Br[Mg][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[O:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>[NH4+].[Cl-].CCOCC>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]([CH3:8])([OH:9])[c:10]1[cH:15][cH:14][c:13]([cH:12][cH:11]1)[O:16][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1|US10214546B2_0764
2.2.3|[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[n&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[c:2]1[nH:3][c:4]([nH:5][cH:6][c:7]1[F:8])=[O:9].[CH3:10][S:11](=[O:12])(=[O:13])Cl>O=C(O[K])O[K].C1COCCO1.CO>[CH3:10][S:11](=[O:12])(=[O:13])[n:5]1[cH:6][c:7]([c:2]([nH:3][c:4]1=[O:9])=[O:1])[F:8]|US20200123117A1_0973
3.10.2|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[F:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[CH3:8][C:9]([CH3:10])([CH3:11])Cl>CC(C)(C)c1ccc(c(c1)O)F.C[N+]([O-])=O.Cl[Al](Cl)Cl>[CH3:8][C:9]([CH3:10])([CH3:11])[c:5]1[cH:6][cH:7][c:2]([cH:3][cH:4]1)[F:1]|US20200017611A1_0085
3.7.2|[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-[#12]-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[O&H1&+0&D1:5])(-[c:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])[CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1.Br[Mg][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>Cl.CCOCC>[CH3:1][C:2]([OH:3])([c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1)[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])[CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1|US20090270361A1_1444
3.10.2|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-Br.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[cH:1]1[cH:2][c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[nH:9]1.[CH3:10][C:11]([CH3:12])([CH3:13])Br>CCCC[N+](CCCC)(CCCC)CCCC.CC(C)N(CC)C(C)C.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.Cc1ccccc1.[NH4+].[Cl-].[I-].[Zn+2]>[CH3:10][C:11]([CH3:12])([CH3:13])[c:2]1[cH:1][nH:9][c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]21|US08367843B2_0136
4.1.24|[N&H0&+0&D1:6]#[C&H0&+0&D2:5]-[N:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#11]>>[n&H0&+0&D2:6]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:5]:1-[N:4]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[O:8][c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)[S:15](=[O:16])(=[O:17])[NH:18][CH:19]1[CH2:20][CH2:21]1)[OH:22])[Cl:23])[NH:24][C:25]#[N:26].[N-:27]=[N+:28]=[N:29][Na]>[NH4+].[Cl-]>[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[O:8][c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)[S:15](=[O:16])(=[O:17])[NH:18][CH:19]1[CH2:20][CH2:21]1)[OH:22])[Cl:23])[NH:24][c:25]1[n:26][n:27][n:28][nH:29]1|US09765030B2_2366
2.2.3|[C&H3&D1:7]-[N&H1&+0&D2:6]-[c:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[c:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[Cl:9])[Cl:10].[O:11]=[S:12](=[O:13])(Cl)[c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1>ClCCl>[CH3:1][N:2]([c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[Cl:9])[Cl:10])[S:12](=[O:11])(=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1|US20200299282A1_0242
10.3.2|[Cl&H0&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-O.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[Cl&H0&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[O:1]=[S:2](=[O:3])(O)[Cl:4].[cH:5]1[cH:6][cH:7][s:8][cH:9]1>Cc1sccc1S(=O)(=O)Cl.ClP(Cl)(Cl)(Cl)Cl>[O:1]=[S:2](=[O:3])([Cl:4])[c:7]1[cH:6][cH:5][cH:9][s:8]1|US20080139558A1_0365
4.1.13|[C:7]-[C&H0&+0&D3:6](-[c:5]:[c&H0&+0&D3:4](:[n:3])-Cl)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](:[n:3]):[c:5]:1|[CH3:1][S:2][c:3]1[n:4][c:5]([c:6]([c:7]([n:8]1)Cl)[C:9](=O)[CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14]1)[Cl:15].[NH2:16][NH2:17]>CC(C)N(CC)C(C)C.C1CCOC1>[CH3:1][S:2][c:3]1[n:4][c:5]([c:6]2[c:9]([n:16][nH:17][c:7]2[n:8]1)[CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14]1)[Cl:15]|US20180148453A1_0300
10.3.2|[Cl&H0&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-O.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[Cl&H0&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[S:2](=[O:3])(O)[Cl:4].[Cl:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[n:13][cH:14][cH:15][nH:16]1>O.O=S(Cl)Cl>[O:1]=[S:2](=[O:3])([Cl:4])[c:14]1[cH:15][nH:16][c:12]([n:13]1)-[c:9]1[cH:10][cH:11][c:6]([cH:7][cH:8]1)[Cl:5]|US09663502B2_0913
10.3.1|[C:7]-[N&H1&+0&D2:6]-[C:5].[O&H0&+0&D1:4]=[S&H0&+0&D3:3](=[O&H0&D1:2])=[O&H0&D1:1]>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](-[O&H1&+0&D1:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[n:10][c:11]([cH:12][s:13]1)[C:14](=[O:15])[C:16](=[O:17])[NH:18][C@@H:19]1[C:20]([NH:21][C@@H:22]1[CH2:23][n:24]1[cH:25][n:26][cH:27][n:28]1)=[O:29].CN(C)C=O.[O:30]=[S:31](=[O:32])=[O:33]>CN(C)C=O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[n:10][c:11]([cH:12][s:13]1)[C:14](=[O:15])[C:16](=[O:17])[NH:18][C@@H:19]1[C:20]([N:21]([C@@H:22]1[CH2:23][n:24]1[cH:25][n:26][cH:27][n:28]1)[S:31](=[O:32])(=[O:33])[OH:30])=[O:29]|EP3122745B1_0798
1.6.8|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C&H3&D1:5])-I.[c:4]:[n&H0&+0&D2:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[C&H1&+0&D3:6](-[C&H3&D1:5])-[n&H0&+0&D3:3](:[c:4]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][CH:2]([CH3:3])I.[CH3:4][O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[n:13][nH:14][c:15]2[c:16]([cH:17][cH:18][cH:19][c:20]12)[CH3:21]>[NaH]>[CH3:4][O:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[c:20]2[cH:19][cH:18][cH:17][c:16]([c:15]2[n:14][n:13]1[CH:2]([CH3:1])[CH3:3])[CH3:21]|US20190307763A1_0330
10.3.2|[Cl&H0&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-O.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[Cl&H0&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[C:2]([CH2:3][S:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[Cl:11])[NH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[O:19]=[S:20](=[O:21])(O)[Cl:22]>Clc1ccccc1Cl>[O:1]=[C:2]([CH2:3][S:4][c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[Cl:11])[S:20](=[O:19])(=[O:21])[Cl:22])[NH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US20050075334A1_0294
2.2.3|[C:7]-[N&H1&+0&D2:6]-[C:5].[Cl&H0&D1:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](-[Cl&H0&D1:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[O:1]=[S:2](=[O:3])([Cl:4])Cl.[cH:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][N:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1>CC#N>[O:1]=[S:2](=[O:3])([Cl:4])[N:15]1[CH2:14][CH2:13][N:12]([CH2:17][CH2:16]1)[CH2:11][c:8]1[cH:9][cH:10][cH:5][cH:6][cH:7]1|US20180179183A1_1227
3.7.2|[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[C:3]1-[C:2]-[C&H1&+0&D3:1]-1-[#12]-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[O&H1&+0&D1:5])(-[c:4])-[C&H1&+0&D3:1]1-[C:3]-[C:2]-1|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[F:10])[F:11].Br[Mg][CH:12]1[CH2:13][CH2:14]1>O.CCOCC.CCOC(C)=O.C1CCOC1>[CH3:1][C:2]([OH:3])([c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[F:10])[F:11])[CH:12]1[CH2:13][CH2:14]1|US09458156B2_1169
4.1.16|[C&H3&D1:7]-[C&H0&+0&D3:6](-O)=O.[C&H3&D1:5]-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D3:4]:1-[C&H3&D1:5]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[NH2:9])[NH:10][CH3:11].[CH3:12][C:13](=O)O>Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[c:8]1[n:9][c:13]([n:10]2[CH3:11])[CH3:12]|US20060194782A1_0624
4.2.20|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H3&D1:5])=O.[O&H1&+0&D1:4]-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6]1(-[C&H3&D1:5])-[O&H0&+0&D2:4]-[c:3]:[c:2]-[O&H0&+0&D2:1]-1|[CH3:1][C:2]([CH3:3])=O.[OH:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[OH:11]>O.O.Cl>[CH3:1][C:2]1([O:11][c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]2[O:4]1)[CH3:3]|EP1916249A1_0040
3.11.45|[O&H0&+0&D1:7]=[C&H0&+0&D2:6]=[O&H0&D1:5].[O&H0&-&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H1&+0&D1:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[c&H0&+0&D3:2](:[c:1]):[c:3]-[O&H1&+0&D1:4]|[Na+].[O-:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[cH:11]1.[O:12]=[C:13]=[O:14]>[O-]c1ccc2ccccc2c1.[K+]>[O:14]=[C:13]([OH:12])[c:3]1[cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[cH:11][c:2]1[OH:1]|EP1095929B1_0004
4.2.20|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H3&D1:5])=O.[O&H1&+0&D1:4]-[C:3]-[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6]1(-[C&H3&D1:5])-[O&H0&+0&D2:4]-[C:3]-[C:2]-[O&H0&+0&D2:1]-1|[CH3:1][C:2]([CH3:3])=O.[O:4]=[C:5]([OH:6])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]([OH:14])[C:15](=[O:16])[OH:17]>O.O=C(O[Na])O[Na].O=S(=O)(O)O>[CH3:1][C:2]1([O:17][C:15]([CH:13]([O:14]1)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:5](=[O:4])[OH:6])=[O:16])[CH3:3]|US20190241528A1_0417
3.11.16|[F&H0&D1:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-I.[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[F&H0&D1:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8][cH:9][cH:10][c:11]2[c:12]1I)[C:13](=[O:14])[O:15][CH3:16].[F:17][C:18]([F:19])([F:20])I>CCOC(C)=O.c1ccncc1.CCOCC.[Cu]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8][cH:9][cH:10][c:11]2[c:12]1[C:18]([F:17])([F:19])[F:20])[C:13](=[O:14])[O:15][CH3:16]|US20040102435A1_0276
9.7.56|[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[C&H0&+0&D3:3](=[O&H0&D1:2])-[N&H0&+0&D2:1]=[N&+]=[N&-]>>[C:7]-[C&H0&+0&D4:6](-[C:5])(-[C:4])-[N&H0&+0&D2:1]=[C&H0&+0&D2:3]=[O&H0&D1:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[C:8]1([CH2:9][CH:10]=[CH:11][CH2:12]1)[C:13](=[O:14])[N:15]=[N+]=[N-]>Cc1ccccc1.COC(C)(C)C>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[C:8]1([CH2:9][CH:10]=[CH:11][CH2:12]1)[N:15]=[C:13]=[O:14]|US07241798B2_0462
2.6.4|[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[c&H0&+0&D3:4](:[c:3]):[c:2].[O&H1&+0&D1:1]-O>>[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[O&H0&+0&D2:1]-[c&H0&+0&D3:4](:[c:3]):[c:2]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[cH:11][cH:12][c:13]2[o:14][c:15]([cH:16][c:17]2[cH:18]1)[C:19](=[O:20])[OH:21].O[OH:22]>CC(=O)O.O=C(O)C(F)(F)F>[CH3:1][C:2](=[O:3])[O:22][c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[c:10]1[cH:11][cH:12][c:13]2[o:14][c:15]([cH:16][c:17]2[cH:18]1)[C:19](=[O:20])[OH:21]|US20110105462A1_0362
1.9.8|[C&H3&D1:7]-[#50&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[C&H3&D1:7]-[#50&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][n:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[cH:12]1.[CH3:13][Sn:14]([CH3:15])([CH3:16])Cl>COc1cc2ccccc2nc1Br.COCCOC.[Na]>[CH3:1][O:2][c:3]1[cH:12][c:11]2[cH:10][cH:9][cH:8][cH:7][c:6]2[n:5][c:4]1[Sn:14]([CH3:13])([CH3:15])[CH3:16]|EP0835252B1_0255
1.9.8|[C&H3&D1:7]-[#50&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[#50&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[F:1][c:2]1[cH:3][cH:4][cH:5][cH:6][n:7]1.[CH3:8][Sn:9]([CH3:10])([CH3:11])Cl>C1CCOC1>[CH3:8][Sn:9]([CH3:10])([CH3:11])[c:3]1[cH:4][cH:5][cH:6][n:7][c:2]1[F:1]|US20110178053A1_1556
2.1.2|[C&H3&D1:7]-[C@&H1&+0&D3:6](-[N:5])-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C&H3&D1:7]-[C&H1&+0&D3:6](-[N:5])-[C&H0&+0&D3:4](-[N&H1&+0&D2:2]-[c:1])=[O&H0&D1:3]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[Cl:16])[N+:17]([O-:18])=[O:19].[CH3:20][C@H:21]([NH:22][C:23](=[O:24])[O:25][CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[C:33](=[O:34])O>ClP(Cl)(Cl)(Cl)Cl.C1CCOC1>[CH3:20][CH:21]([NH:22][C:23](=[O:24])[O:25][CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[C:33](=[O:34])[NH:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[Cl:16])[N+:17]([O-:18])=[O:19]|US20100029643A1_0488
1.2.6|[C&H3&D1:7]-[C&H0&+0&D3:6](-[c:5])=O.[C:4]-[S&H0&+0&D3:3](-[N&H2&+0&D1:2])=[O&H0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D3:6](=[N&H0&+0&D2:2]-[S@&H0&+0&D3:3](-[C:4])=[O&H0&D1:1])-[c:5]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[Br:9].[CH3:10][C:11]([CH3:12])([CH3:13])[S:14]([NH2:15])=[O:16]>CCO[Ti](OCC)(OCC)OCC.C1CCOC1.O.[Na+].[Cl-]>[CH3:1][C:2](=[N:15][S@:14](=[O:16])[C:11]([CH3:10])([CH3:12])[CH3:13])[c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[Br:9]|US20200308166A1_0427
2.1.2|[C:7]-[C@&H1&+0&D3:6](-[N&H2&D1:5])-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[C:2]-[N&H2&+0&D1:1]>>[C:7]-[C&H1&+0&D3:6](-[N&H2&D1:5])-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[ClH:1].[NH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C@H:7]([NH2:8])[C:9](=[O:10])O>[Na+].CCCCCCO.[OH-]>[ClH:1].[NH2:8][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3][NH:2][C:9]1=[O:10]|US06133261A
9.7.227|[C&H3&D1:7]-[S&H0&+0&D3:6](-[O&H0&-&D1:5])=[O&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&+0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1I)[Br:8].[CH3:9][S:10]([O-:11])=[O:12]>O.CS(C)=O.I[Cu]>[CH3:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[S:10]([CH3:9])(=[O:12])=[O:11])[Br:8]|US20160145247A1_2451
1.9.8|[C&H3&D1:7]-[#50&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[s:1]>>[C&H3&D1:7]-[#50&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[s:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]2[s:6][cH:7][cH:8][c:9]2[cH:10]1.[CH3:11][Sn:12]([CH3:13])([CH3:14])Cl>CCCCCC.CCOCC.CCCC[Li].[NH4+].[Cl-]>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[s:6][c:7]([cH:8][c:9]2[cH:10]1)[Sn:12]([CH3:11])([CH3:13])[CH3:14]|US20180026192A1_0364
1.8.3|[C&H3&D1:7]-[S&H0&+0&D3:6](-[O&H0&-&D1:5])=[O&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&+0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][S:2]([O-:3])=[O:4].[O:5]=[S:6](=[O:7])([NH:8][CH2:9][CH2:10][c:11]1[cH:12][c:13]([cH:14][c:15]([cH:16]1)[C:17](=[O:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)F)[CH2:25][CH2:26][C:27](=[O:28])[OH:29])[c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[Cl:36]>O.Cl.CS(C)=O>[CH3:1][S:2](=[O:4])(=[O:3])[c:22]1[cH:23][cH:24][c:19]([cH:20][cH:21]1)[C:17](=[O:18])[c:15]1[cH:16][c:11]([cH:12][c:13]([cH:14]1)[CH2:25][CH2:26][C:27](=[O:28])[OH:29])[CH2:10][CH2:9][NH:8][S:6](=[O:5])(=[O:7])[c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[Cl:36]|US20200069648A1_0298
2.1.2|[C:7]-[C@&H1&+0&D3:6](-[O&H1&D1:5])-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[C:2]-[N&H2&+0&D1:1]>>[C:7]-[C&H1&+0&D3:6](-[O&H1&D1:5])-[C&H0&+0&D3:4](-[N&H1&+0&D2:1]-[C:2])=[O&H0&D1:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]([CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[CH:17]([OH:18])[CH2:19][NH:20][CH2:21][CH:22]([OH:23])[CH:24]([NH2:25])[CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1.[CH3:33][C:34]([CH3:35])([CH3:36])[C@H:37]([OH:38])[C:39](=[O:40])O>>[CH3:33][C:34]([CH3:35])([CH3:36])[CH:37]([OH:38])[C:39](=[O:40])[NH:25][CH:24]([CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[CH:22]([OH:23])[CH2:21][NH:20][CH2:19][CH:17]([OH:18])[CH:9]([CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20050107381A1_0370
7.5.1|[O&H0&+0&D1:8]=[c&H0&+0&D3:7]1:[c:6]:[c:5]:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1>>[O&H1&+0&D1:8]-[C&H1&+0&D3:7]1-[c:6]:[c:5]-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[c:2]:[c:1]-1|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[cH:8][cH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[c:16]2=[O:17]>O.[Na+].C1COCCO1.[BH4-]>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[CH:8]=[CH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[CH:16]2[OH:17]|US20090131423A1_0427
3.9.44|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-C(-O)=O.[c:3]:[c&H1&+0&D2:2]:[n:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[cH:6][cH:7][cH:8][n:9][c:10]2[c:11]([cH:12]1)[N+:13]([O-:14])=[O:15].[CH3:16][C:17]([CH3:18])([CH3:19])C(=O)O>[O-]S(=O)(=O)OOS([O-])(=O)=O.[O-][N+](=O)O[Ag].O=S(=O)(O)O.CC#N.O=C=O.[NH4+].[NH4+].[NH4+].O.[OH-]>[CH3:1][O:2][c:3]1[cH:12][c:11]([c:10]2[n:9][c:8]([cH:7][cH:6][c:5]2[cH:4]1)[C:17]([CH3:16])([CH3:18])[CH3:19])[N+:13]([O-:14])=[O:15]|US20070066624A1_0500
9.7.30|[C&H3&D1:7]-[S&H0&+0&D3:6](-[O&H0&-&D1:5])=[O&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&+0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][N:2]([C:3](=[O:4])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9])[c:10]1[cH:11][c:12]2[cH:13][cH:14][n:15]([c:16]([c:17]2[cH:18][c:19]1[F:20])=[O:21])-[c:22]1[cH:23][cH:24][c:25]([c:26]([cH:27]1)Br)[N+:28]([O-:29])=[O:30].[CH3:31][S:32]([O-:33])=[O:34].[Na+]>CS(C)=O>[CH3:7][C:6]([CH3:8])([CH3:9])[O:5][C:3](=[O:4])[N:2]([CH3:1])[c:10]1[cH:11][c:12]2[cH:13][cH:14][n:15]([c:16]([c:17]2[cH:18][c:19]1[F:20])=[O:21])-[c:22]1[cH:23][cH:24][c:25]([c:26]([cH:27]1)[S:32]([CH3:31])(=[O:33])=[O:34])[N+:28]([O-:29])=[O:30]|EP3294736B1_0263
9.7.47|[C&H3&D1:7]-[S&H0&+0&D3:6](-[O&H0&-&D1:5])=[O&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&+0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[Na+].[CH3:1][c:2]1[n:3][c:4]([c:5]([c:6]([n:7]1)[OH:8])Cl)[OH:9].[CH3:10][S:11]([O-:12])=[O:13]>CS(C)=O>[CH3:1][c:2]1[n:3][c:4]([c:5]([c:6]([n:7]1)[OH:8])[S:11]([CH3:10])(=[O:12])=[O:13])[OH:9]|EP1972631A1_0144
8.8.18|[c:8]:[c&H0&+0&D3:7]1:[c:6]-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[c:3]:[c&H0&+0&D3:2]-1:[n:1]>>[c:8]:[c&H0&+0&D3:7]1:[c:6]:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[n:1]|[cH:1]1[cH:2][c:3]([cH:4][cH:5][n:6]1)-[c:7]1[nH:8][n:9][c:10]2[c:11]1[CH2:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1-2>C1COCCO1.CCO.ClCCl.CO.[Pd]>[cH:1]1[cH:2][c:3]([cH:4][cH:5][n:6]1)-[c:7]1[nH:8][n:9][c:10]2[c:19]3[cH:18][cH:17][cH:16][cH:15][c:14]3[cH:13][cH:12][c:11]21|EP3239153A1_0331
7.6.1|[O&H0&D1:7]=[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c:3]:[c:2]:[o&H0&+0&D2:1]:1>>[O&H0&D1:7]=[C&H0&+0&D3:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[c:3]:[c:2]-[O&H0&+0&D2:1]-1|[O:1]=[c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[o:11]1>CCOC(C)=O.[O-2].[Pt+2]>[O:1]=[C:2]1[CH2:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[O:11]1|US08143424B2_0303
1.2.6|[C&H3&D1:7]-[C&H0&+0&D3:6](-[c:5])=O.[C:4]-[S&H0&+0&D3:3](-[N&H2&+0&D1:2])=[O&H0&D1:1]>>[C&H3&D1:7]/[C&H0&+0&D3:6](=[N&H0&+0&D2:2]\[S@@&H0&+0&D3:3](-[C:4])=[O&H0&D1:1])-[c:5]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[CH3:9].[CH3:10][C:11]([CH3:12])([CH3:13])[S:14]([NH2:15])=[O:16]>CCO[Ti](OCC)(OCC)OCC.C1CCOC1>[CH3:9][c:7]1[cH:6][cH:5][cH:4][c:3]([cH:8]1)[C:2](/[CH3:1])=[N:15]/[S@:14](=[O:16])[C:11]([CH3:10])([CH3:12])[CH3:13]|US09868738B2_0364
1.7.13|[C&H3&D1:7]-[C&H2&+0&D2:6]-I.[O&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[C&H2&+0&D2:6]-[O&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][c:2]1[n:3][c:4]([c:5]([c:6]([nH:7]1)=[O:8])[C:9]#[N:10])[N:11]1[CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]2[CH2:20][CH2:21]1.[CH3:22][CH2:23]I>CN(C)C=O.O=C(O[K])O[K]>[CH3:22][CH2:23][O:8][c:6]1[n:7][c:2]([n:3][c:4]([c:5]1[C:9]#[N:10])[N:11]1[CH2:12][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]2[CH2:20][CH2:21]1)[CH3:1]|US20170239249A1_0302
2.6.2|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C:5])-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:7]-[C@@&H1&+0&D3:6](-[C:5])-[O&H0&+0&D2:4]-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][C@@H:13]1[CH2:14][C:15](=[O:16])O)[C:17]1=[N:18][c:19]2[cH:20][c:21]([cH:22][cH:23][c:24]2[O:25][c:26]2[c:27]1[cH:28][cH:29][cH:30][cH:31]2)[Cl:32].[CH3:33][CH:34]([OH:35])[CH2:36][C:37]([CH3:38])([CH3:39])[OH:40]>CCN=C=NCCCN(C)C.CN(C)c1ccncc1.CN(C)C=O.Cl>[CH3:33][C@H:34]([CH2:36][C:37]([CH3:38])([CH3:39])[OH:40])[O:35][C:15](=[O:16])[CH2:14][C@H:13]1[CH2:12][N:11]([CH2:10][CH2:9][N:8]1[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[C:17]1=[N:18][c:19]2[cH:20][c:21]([cH:22][cH:23][c:24]2[O:25][c:26]2[c:27]1[cH:28][cH:29][cH:30][cH:31]2)[Cl:32]|US10640482B2_0190
4.3.3|[N&H2&+0&D1:6]-[C&H0&+0&D3:5](-[N:4])=[S&H0&+0&D1:3].[C&H1&+0&D2:2](-[C&H2&+0&D2:1]-Cl)=O>>[n&H0&+0&D2:6]1:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:[s&H0&+0&D2:3]:[c&H0&+0&D3:5]:1-[N:4]|[NH2:1][C:2](=[S:3])[NH:4][N:5]=[c:6]1[c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[nH:13][c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21.O=[CH:20][CH2:21]Cl>[Na+].CC([O-])=O.CO>[cH:9]1[cH:10][cH:11][c:12]2[nH:13][c:14]3[cH:15][cH:16][cH:17][cH:18][c:19]3[c:6]([c:7]2[cH:8]1)=[N:5][NH:4][c:2]1[n:1][cH:20][cH:21][s:3]1|US08133911B2_0072
1.8.15|[C&H3&D1:7]-[C&H2&+0&D2:6]-I.[S&H0&+0&D1:5]=[c&H0&+0&D3:4](:[n:3]):[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[C&H2&+0&D2:6]-[S&H0&+0&D2:5]-[c&H0&+0&D3:4](:[n:3]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][CH2:2]I.[CH3:3][O:4][C:5](=[O:6])[c:7]1[s:8][c:9]([c:10]2[nH:11][c:12]([nH:13][c:14]12)=[S:15])[CH3:16]>[Na+].CO.[OH-]>[CH3:16][c:9]1[s:8][c:7]([c:14]2[n:13][c:12]([nH:11][c:10]12)[S:15][CH2:2][CH3:1])[C:5](=[O:6])[O:4][CH3:3]|US20100190747A1_1652
9.7.30|[C&H3&D1:7]-[S&H0&+0&D3:6](-[O&H0&-&D1:5])=[O&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&+0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[O:1]=[C:2]([NH:3][CH2:4][c:5]1[cH:6][cH:7][c:8]([n:9][cH:10]1)Br)[c:11]1[cH:12][n:13][cH:14][c:15]2[c:16]1[cH:17][n:18][n:19]2-[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[F:26].[CH3:27][S:28]([O-:29])=[O:30].[Na+]>[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.CNCCNC.CCOC(C)=O.CS(C)=O.[NH4+].[Cl-].[Cu+2]>[CH3:27][S:28](=[O:30])(=[O:29])[c:8]1[cH:7][cH:6][c:5]([cH:10][n:9]1)[CH2:4][NH:3][C:2](=[O:1])[c:11]1[cH:12][n:13][cH:14][c:15]2[c:16]1[cH:17][n:18][n:19]2-[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[F:26]|US20200361939A1_1987
7.6.1|[O&H0&D1:7]=[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[o&H0&+0&D2:3]:[c:2]:[c:1]:1>>[O&H0&D1:7]=[C&H0&+0&D3:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[O&H0&+0&D2:3]-[c:2]:[c:1]-1|[CH3:1][S:2](=[O:3])(=[O:4])[NH:5][c:6]1[cH:7][c:8]2[o:9][cH:10][cH:11][c:12]([c:13]2[cH:14][c:15]1[O:16][c:17]1[cH:18][cH:19][c:20]([cH:21][c:22]1[F:23])[F:24])=[O:25]>CC(=O)O.[Pd]>[CH3:1][S:2](=[O:3])(=[O:4])[NH:5][c:6]1[cH:7][c:8]2[O:9][CH2:10][CH2:11][C:12]([c:13]2[cH:14][c:15]1[O:16][c:17]1[cH:18][cH:19][c:20]([cH:21][c:22]1[F:23])[F:24])=[O:25]|EP1764367A1_0653
9.7.47|[C&H3&D1:7]-[S&H0&+0&D3:6](-[O&H0&-&D1:5])=[O&H0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&+0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[cH:9][c:10]([n:11][cH:12][c:13]1[C:14](=[O:15])[N:16]([CH3:17])[CH2:18][c:19]1[cH:20][c:21]([cH:22][c:23]([cH:24]1)[C:25]([F:26])([F:27])[F:28])[C:29]([F:30])([F:31])[F:32])Cl.[CH3:33][S:34]([O-:35])=[O:36].[Na+]>CN(C)C=O.O=C(O)O[Na].ClCCl>[CH3:17][N:16]([CH2:18][c:19]1[cH:24][c:23]([cH:22][c:21]([cH:20]1)[C:29]([F:30])([F:31])[F:32])[C:25]([F:26])([F:27])[F:28])[C:14](=[O:15])[c:13]1[cH:12][n:11][c:10]([cH:9][c:8]1-[c:7]1[cH:6][cH:5][cH:4][cH:3][c:2]1[CH3:1])[S:34]([CH3:33])(=[O:36])=[O:35]|EP2681194B1_0870
7.9.12|[C&H3&D1:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D2:1]:1>>[C&H3&D1:7]-[C&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[c:3]:[c:2]-[N&H1&+0&D2:1]-1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[n:7][c:8]([cH:9][cH:10][c:11]2[cH:12]1)[CH3:13]>[Rh]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[NH:7][CH:8]([CH2:9][CH2:10][c:11]2[cH:12]1)[CH3:13]|US20200299295A1_0182
8.8.18|[O&H0&D1:7]=[C&H0&+0&D3:6]1-[N&H1&+0&D2:5]-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1>>[O&H0&D1:7]=[c&H0&+0&D3:6]1:[n&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1|[CH3:1][n:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[c:9]2[C:10]([NH:11][CH2:12][CH2:13][c:14]21)=[O:15]>[O-2].[Pd+2]>[CH3:1][n:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[c:9]2[c:14]1[cH:13][cH:12][nH:11][c:10]2=[O:15]|US20160368872A1_0141
4.1.56|[C&H3&D1:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3]:[c:2]-[C&H2&+0&D2:1]-Br)-O-C>>[C&H3&D1:7]-[N&H0&+0&D3:6]1-[C&H2&+0&D2:1]-[c:2]:[c:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|CO[C:1](=[O:2])[c:3]1[cH:4][cH:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[c:12]1[CH2:13]Br)[C:14](=[O:15])[c:16]1[cH:17][n:18]([cH:19][n:20]1)[C:21]([c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)([c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)[c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1.[CH3:40][NH2:41].CO>C1CCOC1>[CH3:40][N:41]1[CH2:13][c:12]2[c:11]3[cH:10][cH:9][c:8]([cH:7][c:6]3[cH:5][cH:4][c:3]2[C:1]1=[O:2])[C:14](=[O:15])[c:16]1[cH:17][n:18]([cH:19][n:20]1)[C:21]([c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)([c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)[c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1|US20180251449A1_0271
7.6.1|[O&H0&D1:7]=[c&H0&+0&D3:6]1:[c:5]:[c:4]:[c&H1&+0&D2:3]:[c&H1&+0&D2:2]:[n&H1&+0&D2:1]:1>>[O&H0&D1:7]=[C&H0&+0&D3:6]1-[c:5]:[c:4]-[C&H2&+0&D2:3]-[C&H2&+0&D2:2]-[N&H1&+0&D2:1]-1|[CH3:1][c:2]1[n:3][c:4]([cH:5][c:6]2[cH:7][cH:8][nH:9][c:10]([c:11]12)=[O:12])-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>CCO.[H][H].[Pd]>[CH3:1][c:2]1[n:3][c:4]([cH:5][c:6]2[CH2:7][CH2:8][NH:9][C:10]([c:11]12)=[O:12])-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US07294635B2_0387
4.3.3|[C:6]-[C&H0&+0&D3:5](-[N&H2&+0&D1:4])=[S&H0&+0&D1:3].[C&H1&+0&D2:2](-[C&H2&+0&D2:1]-Cl)=O>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:[s&H0&+0&D2:3]:1|[NH2:1][C:2](=[S:3])[CH2:4][c:5]1[cH:6][cH:7][c:8]2[CH2:9][CH2:10][N:11]([c:12]2[cH:13]1)[CH:14]1[CH2:15][CH2:16][N:17]([CH2:18][CH2:19]1)[CH2:20][CH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28].O=[CH:29][CH2:30]Cl>Cl.COCCOC.O=C(O[K])O[K]>[F:28][c:25]1[cH:26][cH:27][c:22]([cH:23][cH:24]1)[CH2:21][CH2:20][N:17]1[CH2:18][CH2:19][CH:14]([CH2:15][CH2:16]1)[N:11]1[CH2:10][CH2:9][c:8]2[cH:7][cH:6][c:5]([cH:13][c:12]21)[CH2:4][c:2]1[n:1][cH:29][cH:30][s:3]1|US20110263647A1_0364
8.8.18|[c:8]:[c&H0&+0&D3:7]1:[c:6]-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[c:3]:[c&H0&+0&D3:2]-1:[c:1]>>[c:8]:[c&H0&+0&D3:7]1:[c:6]:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])-[n:11]1[c:12]([cH:13][c:14]2-[c:15]3[cH:16][cH:17][cH:18][cH:19][c:20]3[CH2:21][CH2:22][c:23]21)-[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>Cc1ccccc1C.[Pd]>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])-[n:11]1[c:23]2[cH:22][cH:21][c:20]3[cH:19][cH:18][cH:17][cH:16][c:15]3[c:14]2[cH:13][c:12]1-[c:24]1[cH:29][cH:28][cH:27][cH:26][cH:25]1|EP1201632B1_0172
7.6.1|[O&H0&D1:7]=[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1>>[O&H0&D1:7]=[C&H0&+0&D3:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[c:3]:[c:2]-[N&H1&+0&D2:1]-1|[O:1]=[c:2]1[cH:3][cH:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[nH:11]1)[O:12][CH2:13][CH2:14][CH2:15][c:16]1[n:17][n:18][n:19][n:20]1[CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1>CO.[Pd]>[O:1]=[C:2]1[CH2:3][CH2:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[NH:11]1)[O:12][CH2:13][CH2:14][CH2:15][c:16]1[n:17][n:18][n:19][n:20]1[CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1|EP0638571A1_0312
8.8.18|[O&H0&D1:7]=[C&H0&+0&D3:6]1-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[c:3]:[c:2]-[N&H1&+0&D2:1]-1>>[O&H0&D1:7]=[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1|[O:1]=[C:2]1[CH2:3][CH2:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[NH:11]1)[O:12][CH2:13][CH2:14][CH2:15][c:16]1[n:17][n:18][n:19][n:20]1[CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1>N#CC1=C(C(C(=C(C1=O)Cl)Cl)=O)C#N.C1COCCO1.ClC(Cl)Cl>[O:1]=[c:2]1[cH:3][cH:4][c:5]2[cH:6][c:7]([cH:8][cH:9][c:10]2[nH:11]1)[O:12][CH2:13][CH2:14][CH2:15][c:16]1[n:17][n:18][n:19][n:20]1[CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1|EP2566329B1_0016
4.1.2|[N&H3&+0&D0:7].[O&H0&D1:6]=[C&H0&+0&D3:5]1-[C:4]=[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-1>>[N&H1&+0&D2:7]1-[C&H0&+0&D3:5](=[O&H0&D1:6])-[C:4]=[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[NH3:1].[CH3:2][n:3]1[cH:4][c:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21)[C:12]1=[C:13]([C:14](O[C:15]1=[O:16])=[O:17])[c:18]1[cH:19][n:20]([c:21]2[cH:22][cH:23][c:24]([cH:25][c:26]12)[N+:27]([O-:28])=[O:29])[CH3:30]>CN(C)C=O>[CH3:30][n:20]1[cH:19][c:18]([c:26]2[cH:25][c:24]([cH:23][cH:22][c:21]21)[N+:27]([O-:28])=[O:29])[C:13]1=[C:12]([C:15]([NH:1][C:14]1=[O:17])=[O:16])[c:5]1[cH:4][n:3]([c:11]2[cH:10][cH:9][cH:8][cH:7][c:6]21)[CH3:2]|US06479490B2
7.6.1|[c:8]:[c&H0&+0&D3:7]1:[c:6]:[c&H1&+0&D2:5]:[c&H1&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1]>>[c:8]:[c&H0&+0&D3:7]1:[c:6]-[C&H2&+0&D2:5]-[C&H2&+0&D2:4]-[c:3]:[c&H0&+0&D3:2]-1:[c:1]|[cH:1]1[cH:2][cH:3][c:4]2[cH:5][cH:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3[c:13]2[cH:14]1>>[cH:1]1[cH:2][cH:3][c:4]2[CH2:5][CH2:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]3-[c:13]2[cH:14]1|US09371270B2_0161
2.1.2|[N&H2&+0&D1:7]-[c:6]:[c:5]/[C&H1&+0&D2:4]=[C&H1&+0&D2:3]/[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[n&H1&+0&D2:7]1:[c:6]:[c:5]:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1]|[NH2:1][c:2]1[n:3][c:4]([n:5]([cH:6][c:7]1/[CH:8]=[CH:9]/[C:10](=[O:11])O)[C@@H:12]1[O:13][C@@H:14]([C@H:15]([C@H:16]1[OH:17])[OH:18])[CH2:19][OH:20])=[O:21]>CN(C)C(On1nnc2ccc(cc21)Cl)=[N+](C)C.On1nnc2ccccc21.CCN(CC)CC.F[P-](F)(F)(F)(F)F.[Cl]>[O:21]=[c:4]1[n:3][c:2]2[nH:1][c:10]([cH:9][cH:8][c:7]2[cH:6][n:5]1[C@@H:12]1[O:13][C@@H:14]([C@H:15]([C@H:16]1[OH:17])[OH:18])[CH2:19][OH:20])=[O:11]|US07879872B2_1597
4.1.69|[C:7]-[C&H0&+0&D4:6](-O-C)(-O-C)-O-C.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[c:1]|CO[C:1]([CH2:2][CH2:3][CH3:4])(OC)OC.[CH3:5][O:6][C:7](=[O:8])[c:9]1[cH:10][cH:11][c:12]2[n:13][c:14]([c:15]([n:16][c:17]2[cH:18]1)[Cl:19])[NH:20][NH2:21]>>[CH3:4][CH2:3][CH2:2][c:1]1[n:21][n:20][c:14]2[c:15]([n:16][c:17]3[cH:18][c:9]([cH:10][cH:11][c:12]3[n:13]21)[C:7](=[O:8])[O:6][CH3:5])[Cl:19]|US09796706B2_0546
3.9.1|[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-Br.[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[C&H1&+0&D3:2](-[C:3])-[O&H1&+0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([F:7])([F:8])Br.[CH3:9][N:10]([CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[C:18](=[O:19])[CH2:20][CH2:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][CH2:27][C@H:28]1[CH:29]=[O:30]>O=C(O)O[Na].C1CCOC1.[Zn]>[CH3:9][N:10]([CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[C:18](=[O:19])[CH2:20][CH2:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][CH2:27][C@H:28]1[CH:29]([OH:30])[C:6]([F:7])([F:8])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20200131209A1_0818
4.3.9|[C&H3&D1:7]-[C&H0&+0&D3:6](=[S&H0&+0&D1:5])-[N&H1&+0&D2:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:5]:[c&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[CH3:9])[NH:10][C:11]([CH3:12])=[S:13]>N#C[Fe-3](C#N)(C#N)(C#N)(C#N)C#N.C1COCCO1.O.[Na+].C.[OH-].[K+].[K+].[K+]>[CH3:1][O:2][c:3]1[cH:4][c:5]2[s:13][c:11]([n:10][c:6]2[cH:7][c:8]1[CH3:9])[CH3:12]|EP3119765B1_0146
4.1.100|[C:7]-[C&H0&+0&D3:6](=[C&H1&+0&D2:5]-[c:4]:[c&H1&+0&D2:3]:[c:2])-[N&H0&+0&D2:1]=[N&+]=[N&-]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c:4]:[c&H0&+0&D3:3](:[c:2]):[n&H1&+0&D2:1]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][c:8]1[cH:9][cH:10][cH:11][s:12]1)[N:13]=[N+]=[N-]>Cc1ccccc1C>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]2[s:12][cH:11][cH:10][c:9]2[nH:13]1|US06130237A
4.1.100|[C:7]-[C&H0&+0&D3:6](=[C&H1&+0&D2:5]-[c:4]:[c&H1&+0&D2:3]:[s:2])-[N&H0&+0&D2:1]=[N&+]=[N&-]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c:4]:[c&H0&+0&D3:3](:[s:2]):[n&H1&+0&D2:1]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][c:8]1[cH:9][s:10][cH:11][c:12]1[Br:13])[N:14]=[N+]=[N-]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]2[c:12]([cH:11][s:10][c:9]2[nH:14]1)[Br:13]|US07884124B2_0640
2.1.2|[C:8]-[C&H1&+0&D3:7](-[C:6])-[C&H0&+0&D3:5](=[O&H0&D1:4])-O.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:8]-[C@&H1&+0&D3:7](-[C:6])-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C:3])-[C:1]|[CH2:1]=[CH:2][CH2:3][N:4]1[CH2:5][CH:6]([CH2:7][C:8]1=[O:9])[C:10](=[O:11])O.[O:12]=[C:13]1[NH:14][C@H:15]([CH2:16][O:17]1)[CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>CC(C)(C)C(=O)Cl.Cl[Li]>[CH2:1]=[CH:2][CH2:3][N:4]1[CH2:5][C@H:6]([CH2:7][C:8]1=[O:9])[C:10](=[O:11])[N:14]1[C:13]([O:17][CH2:16][C@@H:15]1[CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)=[O:12]|EP1802307B1_0163
2.1.2|[C:8]-[N&H1&+0&D2:7]-[C:6].[C:5]-[C&H1&+0&D3:4](-[N:3])-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:8]-[N&H0&+0&D3:7](-[C:6])-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C@&H1&+0&D3:4](-[C:5])-[N:3]|[CH3:1][N:2]([C:3](=[O:4])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9])[CH:10]([CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[C:18](=[O:19])O.[CH3:20][O:21][c:22]1[cH:23][cH:24][c:25]([cH:26][c:27]1[CH:28]1[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]1)[F:34]>CCN=C=NCCCN(C)C.On1nnc2c1cccc2.CN1CCOCC1.CCOC(C)=O.CN(C)C=O.O.O.Cl>[CH3:20][O:21][c:22]1[cH:23][cH:24][c:25]([cH:26][c:27]1[CH:28]1[CH2:29][CH2:30][N:31]([CH2:32][CH2:33]1)[C:18](=[O:19])[C@@H:10]([CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[N:2]([CH3:1])[C:3](=[O:4])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9])[F:34]|US20170137410A1_0234
4.3.9|[N&H2&D1:7]-[C&H0&+0&D3:6](=[S&H0&+0&D1:5])-[N&H1&+0&D2:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[N&H2&D1:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:5]:[c&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:9][C:10]([NH2:11])=[S:12]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[s:12][c:10]([n:9][c:6]2[cH:7][cH:8]1)[NH2:11]|EP3623369A1_0068
1.6.4|[N:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-Cl.[c:5]1:[n&H0&+0&D2:4]:[c:3]:[n&H1&+0&D2:2]:[o:1]:1>>[N:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-[n&H0&+0&D3:4]1:[c:5]:[o:1]:[n&H0&+0&D2:2]:[c:3]:1|[O:1]=[c:2]1[n:3][c:4]([nH:5][o:6]1)-[c:7]1[cH:8][c:9]([cH:10][cH:11][n:12]1)[C:13]([F:14])([F:15])[F:16].[CH3:17][N:18]([CH3:19])[C:20](=[O:21])Cl>C1CN=C2CCCCCN2C1.c1ccncc1>[CH3:17][N:18]([CH3:19])[C:20](=[O:21])[n:3]1[c:2]([o:6][n:5][c:4]1-[c:7]1[cH:8][c:9]([cH:10][cH:11][n:12]1)[C:13]([F:14])([F:15])[F:16])=[O:1]|US20120041009A1_0394
4.1.100|[C:7]-[C&H0&+0&D3:6](=[C&H1&+0&D2:5]-[c:4]:[c&H1&+0&D2:3]:[n:2])-[N&H0&+0&D2:1]=[N&+]=[N&-]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[c:4]:[c&H0&+0&D3:3](:[n:2]):[n&H1&+0&D2:1]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][c:8]1[cH:9][n:10][cH:11][n:12]1-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Br:19])[N:20]=[N+]=[N-]>Cc1ccc(cc1)C>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]2[c:9]([n:10][cH:11][n:12]2-[c:13]2[cH:14][cH:15][c:16]([cH:17][cH:18]2)[Br:19])[nH:20]1|US09085583B2_0634
3.9.79|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H3&D1:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[n:1])-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[n:1]|[CH3:1][C:2]([CH3:3])=[O:4].[Br:5][c:6]1[cH:7][n:8][c:9]([cH:10][cH:11]1)Br>CCCC[Li].Cc1ccccc1>[CH3:1][C:2]([CH3:3])([OH:4])[c:9]1[cH:10][cH:11][c:6]([cH:7][n:8]1)[Br:5]|EP2502909A1_0311
3.9.79|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H3&D1:5])=[O&H0&+0&D1:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[O&H1&+0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[c:9]([n:10][cH:11][n:12][c:13]1[O:14][CH2:15][CH2:16][O:17][c:18]1[n:19][cH:20][c:21]([cH:22][n:23]1)Br)[NH:24][S:25](=[O:26])(=[O:27])[c:28]1[cH:29][cH:30][c:31]([cH:32][cH:33]1)[C:34]([CH3:35])([CH3:36])[CH3:37].[CH3:38][C:39]([CH3:40])=[O:41]>CCCCCC.CCCC[Li].C1CCOC1.[NH4+].[Cl-]>[CH3:35][C:34]([CH3:36])([CH3:37])[c:31]1[cH:30][cH:29][c:28]([cH:33][cH:32]1)[S:25](=[O:26])(=[O:27])[NH:24][c:9]1[n:10][cH:11][n:12][c:13]([c:8]1-[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[CH3:1])[O:14][CH2:15][CH2:16][O:17][c:18]1[n:19][cH:20][c:21]([cH:22][n:23]1)[C:39]([CH3:38])([CH3:40])[OH:41]|EP3643703A1_0404
3.9.1|[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-Br.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C:7]-[C&H0&+0&D4:6](-[F&H0&D1:5])(-[F&H0&D1:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([F:7])([F:8])Br.[O-:9][N+:10](=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[CH:18]=[O:19]>CCOC(C)=O.C1CCOC1.[Zn]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([F:7])([F:8])[CH:18]([OH:19])[c:17]1[cH:16][cH:15][cH:14][cH:13][c:12]1[N+:10]([O-:9])=[O:11]|EP0493209A1_0027
3.10.2|[Cl&H0&D1:7]-[C&H0&+0&D4:6](-[Cl&H0&D1:5])(-[Cl&H0&D1:4])-Cl.[c:3]:[c&H1&+0&D2:2]:[c:1]>>[Cl&H0&D1:7]-[C&H0&+0&D4:6](-[Cl&H0&D1:5])(-[Cl&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[F:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[F:8])[Cl:9].[Cl:10][C:11]([Cl:12])([Cl:13])Cl>Cl[Al](Cl)Cl.O.Cl>[F:8][c:7]1[cH:6][c:5]([c:4]([cH:3][c:2]1[F:1])[Cl:9])[C:11]([Cl:10])([Cl:12])[Cl:13]|EP3084765B1_0098
2.1.2|[C:8]-[N&H1&+0&D2:7]-[C:6].[C:5]-[C&H1&+0&D3:4](-[O:3])-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:8]-[N&H0&+0&D3:7](-[C:6])-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C@&H1&+0&D3:4](-[C:5])-[O:3]|[CH2:1]=[CH:2][C@@H:3]1[CH2:4][C@:5]1([NH:6][C:7](=[O:8])[C@@H:9]1[CH2:10][C@H:11]([CH2:12][NH:13]1)[O:14][c:15]1[cH:16][c:17]([cH:18][c:19]([n:20]1)-[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)-[c:27]1[cH:28][cH:29][cH:30][s:31]1)[C:32](=[O:33])[NH:34][S:35](=[O:36])(=[O:37])[CH:38]1[CH2:39][CH2:40]1.[CH3:41][C:42]([CH3:43])([CH3:44])[NH:45][C:46](=[O:47])[O:48][CH:49]([C:50](=[O:51])O)[C:52]([CH3:53])([CH3:54])[CH3:55]>CN(C)C(On1nnc2c1nccc2)=[N+](C)C.CC(C)N(CC)C(C)C.F[P-](F)(F)(F)(F)F.ClCCl.Cl.Cl>[CH2:1]=[CH:2][C@@H:3]1[CH2:4][C@:5]1([NH:6][C:7](=[O:8])[C@@H:9]1[CH2:10][C@H:11]([CH2:12][N:13]1[C:50](=[O:51])[C@@H:49]([O:48][C:46](=[O:47])[NH:45][C:42]([CH3:41])([CH3:43])[CH3:44])[C:52]([CH3:53])([CH3:54])[CH3:55])[O:14][c:15]1[cH:16][c:17]([cH:18][c:19]([n:20]1)-[c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)-[c:27]1[cH:28][cH:29][cH:30][s:31]1)[C:32](=[O:33])[NH:34][S:35](=[O:36])(=[O:37])[CH:38]1[CH2:39][CH2:40]1|US20200247747A1_0641
9.7.249|[Cl&H0&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[Cl&H0&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|[O:1]=[S:2](=[O:3])(Cl)[Cl:4].Br[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1-[n:11]1[cH:12][cH:13][cH:14][n:15]1>CCCCCC.CCOCC.CCCC[Li]>[O:1]=[S:2](=[O:3])([Cl:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1-[n:11]1[cH:12][cH:13][cH:14][n:15]1|US20090069337A1_0555
2.1.1|[C:8]-[N&H1&+0&D2:7]-[C&H1&+0&D3:6](-[c:5])-[c:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:8]-[N&H0&+0&D3:7](-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1])-[C@&H1&+0&D3:6](-[c:5])-[c:4]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[nH:11][c:12]1[c:13]2[CH2:14][C@@H:15]([NH:16][CH:17]1[c:18]1[cH:19][cH:20][c:21]2[O:22][CH2:23][O:24][c:25]2[cH:26]1)[C:27](=[O:28])[O:29][CH3:30].[O:31]=[C:32](Cl)[CH2:33][Cl:34]>CCN(CC)CC.ClCCl>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[nH:11][c:12]1[c:13]2[CH2:14][C@@H:15]([N:16]([C@@H:17]1[c:18]1[cH:19][cH:20][c:21]2[O:22][CH2:23][O:24][c:25]2[cH:26]1)[C:32](=[O:31])[CH2:33][Cl:34])[C:27](=[O:28])[O:29][CH3:30]|US20200299283A1_0474
2.1.1|[C:8]-[C&H1&+0&D3:7](-[C:6])-[N&H1&+0&D2:5]-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl>>[C:8]-[C@&H1&+0&D3:7](-[C:6])-[N&H0&+0&D3:5](-[C:4])-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1]|[CH3:1][CH:2]([CH3:3])[CH:4]1[CH2:5][O:6][C:7]([NH:8]1)=[O:9].[O:10]=[C:11](Cl)[CH2:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>CCCCCC.CCCC[Li].C1CCOC1>[CH3:1][CH:2]([CH3:3])[C@@H:4]1[CH2:5][O:6][C:7]([N:8]1[C:11](=[O:10])[CH2:12][CH2:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)=[O:9]|EP0342541A2_0160
2.1.2|[C:8]-[N&H1&+0&D2:7]-[C&H1&+0&D3:6](-[C:5])-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:8]-[N&H0&+0&D3:7](-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1])-[C@@&H1&+0&D3:6](-[C:5])-[C:4]|[CH3:1][CH2:2][O:3][P:4](=[O:5])([CH2:6][CH2:7][CH2:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[CH2:16][C:17](=[O:18])O.[O:19]=[C:20]([OH:21])[CH:22]1[CH2:23][C:24]2([CH2:25][NH:26]1)[S:27][CH2:28][CH2:29][S:30]2.Cl>O=C(n1cncc1)n1cncc1.CCN(CC)CC.CC#N>[CH3:1][CH2:2][O:3][P:4](=[O:5])([CH2:6][CH2:7][CH2:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[CH2:16][C:17](=[O:18])[N:26]1[CH2:25][C:24]2([CH2:23][C@H:22]1[C:20](=[O:19])[OH:21])[S:27][CH2:28][CH2:29][S:30]2|US08927546B2_1094
1.6.8|[C:8]-[C&H2&+0&D2:7]-I.[c:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4](:[s:3])-[N&H1&+0&D2:2]-[c:1]>>[C:8]-[C&H2&+0&D2:7]-[n&H0&+0&D3:5](:[c:6]):[c&H0&+0&D3:4](:[s:3])=[N&H0&+0&D2:2]-[c:1]|[CH3:1][CH2:2][CH2:3]I.[CH3:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[NH:11][c:12]1[n:13][c:14]([c:15]2[cH:16][cH:17][cH:18][n:19][c:20]2[s:21]1)=[O:22]>CN(C)C=O.[LiH]>[CH3:4][c:5]1[cH:10][cH:9][c:8]([cH:7][cH:6]1)[N:11]=[c:12]1[s:21][c:20]2[n:19][cH:18][cH:17][cH:16][c:15]2[c:14]([n:13]1[CH2:3][CH2:2][CH3:1])=[O:22]|US06133258A
2.1.2|[C:8]-[N&H1&+0&D2:7]-[C:6].[C:5]-[C@@&H1&+0&D3:4](-[N:3])-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:8]-[N&H0&+0&D3:7](-[C:6])-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C&H1&+0&D3:4](-[C:5])-[N:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@H:9]([CH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17])[C:18](=[O:19])O.[OH:20][CH2:21][C:22]1([CH2:23][CH2:24][NH:25][CH2:26][CH2:27]1)[N:28]1[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1>>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]([CH2:10][c:11]1[cH:16][cH:15][c:14]([cH:13][cH:12]1)[Cl:17])[C:18](=[O:19])[N:25]1[CH2:24][CH2:23][C:22]([CH2:27][CH2:26]1)([CH2:21][OH:20])[N:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1|US08680114B2_0735
4.1.45|[C&H3&D1:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[N&H0&+0&D1:2]#[C&H0&+0&D2:1]-Br>>[C&H3&D1:7]-[n&H0&+0&D3:6]1:[c&H0&+0&D3:1](-[N&H2&+0&D1:2]):[n&H0&+0&D2:3]:[c:4]:[c:5]:1|[CH3:1][NH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[NH2:9])[N+:10]([O-:11])=[O:12].[N:13]#[C:14]Br>CO>[CH3:1][n:2]1[c:3]2[cH:4][cH:5][c:6]([cH:7][c:8]2[n:9][c:14]1[NH2:13])[N+:10]([O-:11])=[O:12]|US10640518B2_0393
2.1.2|[C:8]-[N&H1&+0&D2:7]-[C:6].[C:5]-[C&H1&+0&D3:4](-[c:3])-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:8]-[N&H0&+0&D3:7](-[C:6])-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C@@&H1&+0&D3:4](-[C:5])-[c:3]|[O:1]=[C:2](O)[CH:3]([CH2:4][CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1)[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[Cl:16])[Cl:17].[CH3:18][CH:19]([CH3:20])[C@H:21]1[CH2:22][O:23][C:24]([NH:25]1)=[O:26]>CCN(CC)CC.CC(C)(C)C(=O)Cl.CCCC[Li].C1CCOC1>[CH3:18][CH:19]([CH3:20])[C@H:21]1[CH2:22][O:23][C:24]([N:25]1[C:2](=[O:1])[C@@H:3]([CH2:4][CH:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1)[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[Cl:16])[Cl:17])=[O:26]|US20200129627A1_2383
2.8.1|[C&H3&D1:7]-[C&H0&+0&D3:6](=[N&H0&+0&D2:5]-[O&H1&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:4])-[N&H1&+0&D2:5]-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[o:14]1)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[C:21]([CH3:22])=[N:23][OH:24]>ClP(Cl)(Cl)(Cl)Cl.ClC(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[o:14]1)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[NH:23][C:21]([CH3:22])=[O:24]|US09873704B2_0222
1.6.8|[C:8]-[C&H2&+0&D2:7]-I.[S:6]-[N&H1&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[c:1]>>[C:8]-[C&H2&+0&D2:7]-[n&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:4](:[c:3])=[N&H0&+0&D2:5]-[S:6]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[NH:11][c:12]1[cH:13][cH:14][c:15]([cH:16][n:17]1)[F:18].[NH2:19][C:20](=[O:21])[CH2:22]I>CN(C)C=O.[NaH]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[N:11]=[c:12]1[cH:13][cH:14][c:15]([cH:16][n:17]1[CH2:22][C:20]([NH2:19])=[O:21])[F:18]|US08431608B2_0260
1.7.12|[C:8]/[C&H1&+0&D2:7]=[C&H1&+0&D2:6]/[C:5].[O&H1&+0&D1:4]-[C&H1&+0&D3:3](-[c:2])-[c:1]>>[C:8]-[C@@&H1&+0&D3:7](-[O&H0&+0&D2:4]-[C@&H1&+0&D3:3](-[c:2])-[c:1])-[C&H2&+0&D2:6]-[C:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])/[CH:6]=[CH:7]/[C:8](=[O:9])[N:10]([CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[O:18][CH3:19])[O:20][CH3:21])[c:22]1[cH:23][cH:24][c:25]([cH:26][c:27]1[CH:28]([OH:29])[c:30]1[cH:31][cH:32][cH:33][c:34]([c:35]1[Cl:36])[O:37][CH3:38])[Cl:39]>CCO.O=C(O[K])O[K]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C@H:7]1[O:29][C@@H:28]([c:27]2[cH:26][c:25]([cH:24][cH:23][c:22]2[N:10]([C:8]1=[O:9])[CH2:11][c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[O:18][CH3:19])[O:20][CH3:21])[Cl:39])[c:30]1[cH:31][cH:32][cH:33][c:34]([c:35]1[Cl:36])[O:37][CH3:38]|EP1939205A1_4686
1.6.2|[C:8]-[C&H2&+0&D2:7]-Br.[C:6]-[N&H1&+0&D2:5]-[c&H0&+0&D3:4](:[s:3]):[n&H0&+0&D2:2]:[c:1]>>[C:8]-[C&H2&+0&D2:7]-[n&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:4](:[s:3])=[N&H0&+0&D2:5]-[C:6]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]2[n:9][c:10]([s:11][c:12]2[cH:13]1)[NH:14][C:15](=[O:16])[C:17]12[CH2:18][CH:19]3[CH2:20][CH:21]([CH2:22][CH:23]([CH2:24]3)[CH2:25]1)[CH2:26]2.[CH3:27][O:28][CH2:29][CH2:30]Br>[NaH]>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]2[c:12]([cH:13]1)[s:11][c:10]([n:9]2[CH2:30][CH2:29][O:28][CH3:27])=[N:14][C:15](=[O:16])[C:17]12[CH2:18][CH:19]3[CH2:20][CH:21]([CH2:22][CH:23]([CH2:24]3)[CH2:25]1)[CH2:26]2|US20150011528A1_0856
5.5.2|[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c:4].[O&H1&+0&D1:3]-[C:2]-[C&H2&+0&D2:1]-O>>[C&H3&D1:7]-[C&H0&+0&D4:6]1(-[O&H0&+0&D2:5]-[C&H2&+0&D2:1]-[C:2]-[O&H0&+0&D2:3]-1)-[c:4]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][c:8]2[C:9]([c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][CH2:17][c:18]21)=[O:19].[OH:20][CH2:21][CH2:22]O>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][C:2]1([O:3][CH2:22][CH2:21][O:20]1)[c:4]1[cH:5][cH:6][cH:7][c:8]2[C:9]([c:10]3[cH:11][cH:12][cH:13][cH:14][c:15]3[CH2:16][CH2:17][c:18]21)=[O:19]|EP2091918B1_0113
4.1.30|[N&H2&+0&D1:7]-[C&H1&+0&D2:6]=O.[N&H2&+0&D1:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[n&H1&+0&D2:7]1:[c&H1&+0&D2:6]:[n&H0&+0&D2:5]:[c:4]:[c:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1]|[CH3:1][N:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[C:10](=[O:11])O)[NH2:12].[NH2:13][CH:14]=O>O>[CH3:1][N:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]2[n:12][cH:14][nH:13][c:10]([c:8]2[cH:9]1)=[O:11]|EP3299366A1_0095
4.1.79|[C:7]-[N&H0&+0&D2:6]=[N&H0&+&D2:5]=[N&H0&-&D1:4].[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[C:7]-[n&H0&+0&D3:6]1:[c&H0&+0&D3:2](-[C:3]):[n&H0&+0&D2:1]:[n&H0&+0&D2:4]:[n&H0&+0&D2:5]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]#[N:7].[CH3:8][CH2:9][O:10][C:11](=[O:12])[CH2:13][N:14]=[N+:15]=[N-:16]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][n:16][n:15][n:14]1[CH2:13][C:11](=[O:12])[O:10][CH2:9][CH3:8]|US09914726B2_0038
5.5.2|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C:5])=[O&H0&+0&D1:4].[O&H1&+0&D1:3]-[C:2]-[C&H2&+0&D2:1]-O>>[C&H3&D1:7]-[C&H0&+0&D4:6]1(-[C:5])-[O&H0&+0&D2:4]-[C&H2&+0&D2:1]-[C:2]-[O&H0&+0&D2:3]-1|[CH3:1][C@@:2]12[CH2:3][C@@H:4]([C@H:5]([CH2:6][C@@H:7]2[CH2:8][CH2:9][C@@H:10]2[C@@H:11]1[C:12]([CH2:13][C@:14]1([C@H:15]2[CH2:16][CH2:17][C@@H:18]1[C:19]([CH3:20])=[O:21])[CH3:22])=[O:23])[OH:24])[O:25][CH2:26][CH2:27][Cl:28].[OH:29][CH2:30][CH2:31]O>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1>[CH3:22][C@@:14]12[CH2:13][C:12]([C@H:11]3[C@@H:10]([CH2:9][CH2:8][C@H:7]4[CH2:6][C@@H:5]([C@H:4]([CH2:3][C@:2]34[CH3:1])[O:25][CH2:26][CH2:27][Cl:28])[OH:24])[C@@H:15]2[CH2:16][CH2:17][C@@H:18]1[C:19]1([O:21][CH2:31][CH2:30][O:29]1)[CH3:20])=[O:23]|US20200109141A1_1320
5.5.4|[C:8]-[C&H0&+0&D3:7](=[O&H0&+0&D1:6])-[c:5].[O&H1&+0&D1:4]-[C:3]-[C:2]-[C&H2&+0&D2:1]-O>>[C:8]-[C&H0&+0&D4:7]1(-[O&H0&+0&D2:6]-[C&H2&+0&D2:1]-[C:2]-[C:3]-[O&H0&+0&D2:4]-1)-[c:5]|[CH3:1][CH:2]([CH3:3])[C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[Br:12].[OH:13][CH2:14][CH2:15][CH2:16]O>>[CH3:1][CH:2]([CH3:3])[C:4]1([O:5][CH2:16][CH2:15][CH2:14][O:13]1)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[Br:12]|US07705155B2_0231
4.1.42|[N&H2&+0&D1:8]-[c:7]:[c:6]-[C&H0&+0&D2:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[n&H1&+0&D2:8]1:[c&H0&+0&D3:4](:[c&H1&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)[C:8]#[C:9][c:10]1[cH:11][c:12]([cH:13][cH:14][c:15]1[NH2:16])[N+:17]([O-:18])=[O:19])[CH3:20]>Cl[Pd]Cl>[CH3:20][c:4]1[cH:3][c:2]([cH:7][c:6]([cH:5]1)-[c:8]1[cH:9][c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[nH:16]1)[N+:17]([O-:18])=[O:19])[CH3:1]|US09676748B2_0730
2.4.4|[N&H2&+0&D1:6]-[c:5]:[c:4]-[O&H1&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[n&H1&+0&D2:6]1:[c:5]:[c:4]:[o&H0&+0&D2:3]:[c&H0&+0&D3:1]:1=[O&H0&D1:2]|[O:1]=[C:2](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[NH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[OH:10])[F:11]>Oc1ccccc1.c1ccncc1.ClCCl.Cl>[O:1]=[c:2]1[nH:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[o:10]1)[F:11]|US20100324030A1_0207
1.2.14|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C:5].[C:4]-[C@&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C:5])-[C&H2&+0&D2:2]-[C@&H1&+0&D3:3](-[C:4])-[O&H1&+0&D1:1]|[CH3:1][NH:2][CH2:3][c:4]1[cH:5][cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n:13]1.[O-:14][N+:15](=[O:16])[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[O:23][CH2:24][C@H:25]1[CH2:26][O:27]1>CC#N>[CH3:1][N:2]([CH2:3][c:4]1[cH:5][cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n:13]1)[CH2:26][C@@H:25]([OH:27])[CH2:24][O:23][c:20]1[cH:21][cH:22][c:17]([cH:18][cH:19]1)[N+:15]([O-:14])=[O:16]|US10174016B2_2280
4.1.4|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[C:4]-[N&H0&+0&D2:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[c&H1&+0&D2:7]1:[n&H0&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D3:3](-[C:4]):[c&H0&+0&D3:6]:1-[C:5]|[CH:1]#[C:2][CH2:3][OH:4].[N-:5]=[N+:6]=[N:7][CH2:8][CH2:9][N:10]1[C:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[C:18]1=[O:19])=[O:20]>Cc1ccccc1>[O:20]=[C:11]1[c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[C:18]([N:10]1[CH2:9][CH2:8][n:7]1[n:6][n:5][cH:1][c:2]1[CH2:3][OH:4])=[O:19]|US20200308213A1_0146
4.1.46|[N&H2&+0&D1:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[n&H1&+0&D2:6]1:[c:5]:[c:4]:[n&H1&+0&D2:3]:[c&H0&+0&D3:1]:1=[O&H0&D1:2]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:7]([c:8]([c:9]1[NH2:10])[NH2:11])[CH3:12].[O:13]=[C:14](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>CN(C)C=O.ClCCl>[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:7]([c:8]2[nH:11][c:14]([nH:10][c:9]12)=[O:13])[CH3:12]|US20200095261A1_0396
4.1.58|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H1&+0&D2:5]=O)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|Cl.[CH3:1][C:2](=O)[CH:3]=O.[NH2:4][c:5]1[nH:6][c:7]([n:8][c:9]([c:10]1[NH2:11])[NH2:12])=[O:13]>O>[CH3:1][c:2]1[cH:3][n:11][c:10]2[c:9]([n:8][c:7]([nH:6][c:5]2[n:4]1)=[O:13])[NH2:12]|EP1310485A1_0278
4.1.49|[C:8]-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[C:5])=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[C&H1&+0&D2:1]=O>>[C:8]-[c&H0&+0&D3:7]1:[c&H1&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7][C:8](=[O:9])[O:10][CH2:11][CH3:12].[NH2:13][c:14]1[cH:15][cH:16][o:17][c:18]1[CH:19]=O>CCOC(OCC)C([O-])=O.CCO.[N-]=[N+]=Nc1ccoc1C=O.C1CCNCC1>[CH3:12][CH2:11][O:10][C:8](=[O:9])[c:7]1[cH:19][c:18]2[o:17][cH:16][cH:15][c:14]2[n:13][c:6]1[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20130085131A1_0197
2.8.5|[C&H3&D1:7]-[C&H0&+0&D3:6](-[O&H0&-&D1:5])=[S&H0&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-O>>[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[S&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[cH:9][cH:10][c:11]([n:12]1)/[CH:13]=[C:14]1\[CH2:15][N:16]([CH2:17][CH2:18][CH:19]1O)[C:20]([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)([c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1.[CH3:39][C:40]([O-:41])=[S:42].[K+]>CCN(CC)CC.CS(=O)(=O)Cl.ClCCl.O>[CH3:39][C:40](=[O:41])[S:42][CH:19]1[CH2:18][CH2:17][N:16]([CH2:15]/[C:14]1=[CH:13]\[c:11]1[cH:10][cH:9][n:8]([n:12]1)[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[C:20]([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)([c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1|EP1600451A2_0175
4.1.103|[C:8]-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[C:5])=N-[N&H1&+0&D2:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:8]-[c&H0&+0&D3:7]1:[c&H0&+0&D3:2](:[c:1]):[c:3]:[n&H1&+0&D2:4]:[c&H0&+0&D3:6]:1-[C:5]|[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[NH:7]N=[C:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1>Cl.c1ccncc1>[cH:6]1[cH:1][cH:2][c:3]2[c:9]3[CH2:10][CH2:11][CH2:12][CH2:13][c:8]3[nH:7][c:4]2[cH:5]1|US09611217B2_0091
4.1.40|[N&H2&+0&D1:7]-[C&H1&+0&D2:6]=N.[N&H2&+0&D1:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[n&H1&+0&D2:7]1:[c&H1&+0&D2:6]:[n&H0&+0&D2:5]:[c:4]:[c:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1]|CC(=O)O.N=[CH:1][NH2:2].[NH2:3][c:4]1[cH:5][n:6][c:7]([cH:8][c:9]1[C:10](=[O:11])O)[F:12]>O.COCCO>[O:11]=[c:10]1[nH:2][cH:1][n:3][c:4]2[cH:5][n:6][c:7]([cH:8][c:9]21)[F:12]|US20200407344A1_0679
4.1.4|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[C:4]-[N&H0&+0&D2:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:6](-[C:5]):[n&H0&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D3:3]:1-[C:4]|[CH:1]#[C:2][C:3](=[O:4])[OH:5].[N-:6]=[N+:7]=[N:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>CC(C)=O>[O:4]=[C:3]([OH:5])[c:2]1[cH:1][n:8]([n:7][n:6]1)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|EP3083601B1_0208
2.3.2|[C&H3&D1:7]-[N&H1&+0&D2:6]-[N&H2&D1:5].[S&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[N&H2&D1:5])-[C&H0&+0&D3:3](=[S&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][NH:2][NH2:3].[O:4]=[C:5]([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[c:12]1[cH:13][c:14]([cH:15][cH:16][c:17]1[N:18]=[C:19]=[S:20])[Cl:21]>CCOCC.[N-]=C=S>[CH3:1][N:2]([NH2:3])[C:19](=[S:20])[NH:18][c:17]1[cH:16][cH:15][c:14]([cH:13][c:12]1[C:5](=[O:4])[c:6]1[cH:11][cH:10][cH:9][cH:8][cH:7]1)[Cl:21]|US05108486A
2.1.24|[C:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[c&H0&+0&D3:4](:[c:3]):[c:2].[N&H0&+0&D2:1](-[#11])=[N&+]=[N&-]>>[C:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[N&H1&+0&D2:1]-[c&H0&+0&D3:4](:[c:3]):[c:2]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[CH2:7][CH2:8][CH2:9][C:10]([c:11]2[cH:12]1)=[O:13].[N-]=[N+]=[N:14][Na]>CC(=O)O.O=S(=O)(O)O.O[Na]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[CH2:7][CH2:8][CH2:9][C:10]([NH:14][c:11]2[cH:12]1)=[O:13]|US20200270273A1_0230
2.3.1|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C&H3&D1:5].[O&H0&D1:4]=[C&H0&+0&D2:3]=[N&H0&+0&D2:2]-[c:1]>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C&H3&D1:5])-[C&H0&+0&D3:3](=[O&H0&D1:4])-[N&H1&+0&D2:2]-[c:1]|[CH3:1][NH:2][CH3:3].[CH3:4][S:5](=[O:6])(=[O:7])[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[Cl:15])[N:16]=[C:17]=[O:18]>Clc1ccccc1>[CH3:4][S:5](=[O:6])(=[O:7])[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[Cl:15])[NH:16][C:17](=[O:18])[N:2]([CH3:1])[CH3:3]|US04959092A
7.6.1|[c:8]:[c&H0&+0&D3:7](:[c:6])-[c&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1>>[c:8]:[c&H0&+0&D3:7](:[c:6])-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[c:3]:[c:2]-[N&H1&+0&D2:1]-1|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[cH:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[nH:16]1>O.[Na+].CC(=O)O.N#C[BH3-]>[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[CH:8]1[CH2:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[NH:16]1|EP0406734A2_0071
1.2.14|[C&H3&D1:7]-[C@@&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:7]-[C@&H1&+0&D3:6](-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:3]):[n:1])-[O&H1&+0&D1:4]|[cH:1]1[n:2][nH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]12.[CH3:10][C@H:11]1[CH2:12][O:13]1>CC(C)(C)O.CC(C)(C)[O-].C1CCOC1.[K+]>[CH3:10][C@H:11]([OH:13])[CH2:12][n:3]1[n:2][cH:1][c:9]2[cH:8][cH:7][cH:6][cH:5][c:4]21|EP3322706B1_1274
1.2.14|[C&H3&D1:7]-[C@@&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:7]-[C@&H1&+0&D3:6](-[C&H2&+0&D2:5]-[N&H0&+0&D3:2](-[C:3])-[C:1])-[O&H1&+0&D1:4]|[CH3:1][CH2:2][S:3](=[O:4])(=[O:5])[CH2:6][CH2:7][c:8]1[cH:9][cH:10][c:11]2[nH:12][cH:13][c:14]([c:15]2[cH:16]1)[CH2:17][C@H:18]1[CH2:19][CH2:20][CH2:21][NH:22]1.[CH3:23][C@H:24]1[CH2:25][O:26]1.Cl>CCN(CC)CC.CO.O>[CH3:23][C@H:24]([OH:26])[CH2:25][N:22]1[CH2:21][CH2:20][CH2:19][C@@H:18]1[CH2:17][c:14]1[cH:13][nH:12][c:11]2[cH:10][cH:9][c:8]([cH:16][c:15]21)[CH2:7][CH2:6][S:3](=[O:4])(=[O:5])[CH2:2][CH3:1]|US20200055860A1_1286
1.9.4|[C&H3&D1:7]-[#50&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:7]-[#50&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|Br[c:1]1[cH:2][cH:3][cH:4][n:5][cH:6]1.[CH3:7][Sn:8]([CH3:9])([CH3:10])Cl>CCCCCC.c1ccccc1.CCOCC.CCCC[Li].[NH4+].O.[Cl-]>[CH3:7][Sn:8]([CH3:9])([CH3:10])[c:1]1[cH:6][n:5][cH:4][cH:3][cH:2]1|US20040072871A1_0459
2.8.5|[C&H3&D1:7]-[C&H0&+0&D3:6](-[O&H1&+0&D1:5])=[S&H0&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-O>>[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[S&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][C:8]#[C:9][CH2:10][CH:11](O)[CH2:12][O:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24].[CH3:25][C:26]([OH:27])=[S:28]>Cc1ccccc1.CCN(CC)CC.CC(C)=O>[CH3:24][CH2:23][CH2:22][CH2:21][CH2:20][c:17]1[cH:16][cH:15][c:14]([cH:19][cH:18]1)[O:13][CH2:12][CH:11]([CH2:10][C:9]#[C:8][CH2:7][CH2:6][CH2:5][C:3](=[O:4])[O:2][CH3:1])[S:28][C:26]([CH3:25])=[O:27]|EP0411636A2_0092
4.2.22|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C&H3&D1:5].[O&H1&+0&D1:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:6](-[C&H3&D1:5]):[o&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])Br)[F:12].[CH:13]#[C:14][CH3:15]>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.I[Cu]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([cH:8][c:9]2[cH:13][c:14]([o:11][c:10]12)[CH3:15])[F:12]|EP3421458B1_0553
2.3.1|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C:5].[C&H3&D1:4]-[N&H0&+0&D2:3]=[C&H0&+0&D2:2]=[O&H0&D1:1]>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:2](=[O&H0&D1:1])-[N&H1&+0&D2:3]-[C&H3&D1:4]|[CH3:1][NH:2][C:3](=[O:4])[N:5]1[CH2:6][CH2:7][N:8]([CH2:9][CH2:10]1)[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[C:17]([F:18])([F:19])[F:20].[CH3:21][N:22]=[C:23]=[O:24]>Cl[Sn](Cl)(Cl)Cl.ClCCl>[CH3:21][NH:22][C:23](=[O:24])[N:2]([CH3:1])[C:3](=[O:4])[N:5]1[CH2:6][CH2:7][N:8]([CH2:9][CH2:10]1)[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[C:17]([F:18])([F:19])[F:20]|US20050113419A1_0162
4.3.9|[N&H0&+0&D1:7]#[C&H0&+0&D2:6]-[S&H0&-&D1:5].[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[N&H2&+0&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[s&H0&+0&D2:5]:1):[c:1]|[NH4+].[N:1]#[C:2][S-:3].[NH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=[O:12])[OH:13]>O.CC(=O)O.BrBr>[NH2:1][c:2]1[n:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[s:3]1)[C:11](=[O:12])[OH:13]|EP3484894B1_1524
1.2.14|[C&H3&D1:7]-[C@&H1&+0&D3:6]1-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[C@@&H1&+0&D3:6](-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:3]):[c:1])-[O&H1&+0&D1:4]|[CH3:1][C@H:2]1[CH2:3][O:4]1.[F:5][c:6]1[cH:7][cH:8][c:9]2[nH:10][cH:11][cH:12][c:13]2[cH:14]1>O.CCOCC.C1CCOC1.[NaH]>[CH3:1][C@H:2]([OH:4])[CH2:3][n:10]1[cH:11][cH:12][c:13]2[cH:14][c:6]([cH:7][cH:8][c:9]21)[F:5]|US20200317637A1_0781
2.8.5|[C&H3&D1:7]-[C&H0&+0&D3:6](-[O&H0&-&D1:5])=[S&H0&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[C:1])-Br>>[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[S&H0&+0&D2:4]-[C&H1&+0&D3:2](-[C:3])-[C:1]|[CH3:1][CH:2]([C:3](=[O:4])[N:5]1[CH2:6][CH2:7][CH2:8][C@H:9]1[C:10](=[O:11])[OH:12])[CH:13](Br)[C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[CH3:22][C:23]([O-:24])=[S:25].[K+]>CCO>[CH3:22][C:23](=[O:24])[S:25][CH:13]([C:14](=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[CH:2]([CH3:1])[C:3](=[O:4])[N:5]1[CH2:6][CH2:7][CH2:8][C@H:9]1[C:10](=[O:11])[OH:12]|EP0981366B1_0041
8.8.18|[c:8]:[c&H0&+0&D3:7](:[c:6])-[N&H0&+0&D3:5]1-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1>>[c:8]:[c&H0&+0&D3:7](:[c:6])-[n&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1|[cH:1]1[cH:2][cH:3][c:4]([cH:5][cH:6]1)[C:7]1=[N:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[N:15]2[CH2:16][CH2:17][c:18]3[cH:19][cH:20][cH:21][c:22]1[c:23]32>Cc1ccccc1C.N#CC1=C(C(C(=C(C1=O)Cl)Cl)=O)C#N>[cH:1]1[cH:6][cH:5][c:4]([cH:3][cH:2]1)[C:7]1=[N:8][c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2-[n:15]2[cH:16][cH:17][c:18]3[cH:19][cH:20][cH:21][c:22]1[c:23]32|US09688683B2_0173
7.6.1|[c:8]:[c&H0&+0&D3:7](:[c:6])-[n&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c:2]:[c:1]:1>>[c:8]:[c&H0&+0&D3:7](:[c:6])-[N&H0&+0&D3:5]1-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[c:2]:[c:1]-1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[cH:9][cH:10][n:11]2-[c:12]1[cH:13][c:14]([cH:15][cH:16][cH:17]1)[C:18]#[N:19]>O.[Na+].[Na+].CC(=O)O.N#C[BH3-].[OH-]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[CH2:9][CH2:10][N:11]2[c:12]1[cH:17][cH:16][cH:15][c:14]([cH:13]1)[C:18]#[N:19]|US08222261B2_0484
2.1.2|[C:8]-[C&H0&+0&D4:7](-[C:6])(-[C:5])-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[c:1])-O>>[C:8]-[C@@&H0&+0&D4:7](-[C:6])(-[C:5])-[N&H1&+0&D2:4]-[C&H0&+0&D3:2](=[O&H0&D1:3])-[c:1]|[NH2:1][C:2]1([CH2:3][CH2:4][N:5]([CH2:6]1)[c:7]1[n:8][cH:9][cH:10][n:11]2[cH:12][cH:13][cH:14][c:15]12)[CH2:16][OH:17].[O:18]=[C:19](O)[c:20]1[n:21][cH:22][n:23]([n:24]1)-[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>Cl.Cl>[O:18]=[C:19]([NH:1][C@:2]1([CH2:3][CH2:4][N:5]([CH2:6]1)[c:7]1[n:8][cH:9][cH:10][n:11]2[cH:12][cH:13][cH:14][c:15]12)[CH2:16][OH:17])[c:20]1[n:21][cH:22][n:23]([n:24]1)-[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1|
7.6.1|[c:8]:[c&H0&+0&D3:7](:[c:6])-[c&H0&+0&D3:5]1:[c&H1&+0&D2:4]:[o&H0&+0&D2:3]:[c:2]:[c:1]:1>>[c:8]:[c&H0&+0&D3:7](:[c:6])-[C&H1&+0&D3:5]1-[C&H2&+0&D2:4]-[O&H0&+0&D2:3]-[c:2]:[c:1]-1|[CH3:1][c:2]1[c:3]([cH:4][c:5]([c:6]2[c:7]([cH:8][o:9][c:10]12)-[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[Br:17])[CH3:18])[CH3:19]>CCCCCC.CCOC(C)=O>[CH3:1][c:2]1[c:3]([cH:4][c:5]([c:6]2[c:10]1[O:9][CH2:8][CH:7]2[c:11]1[cH:16][c:15]([cH:14][cH:13][cH:12]1)[Br:17])[CH3:18])[CH3:19]|US07507841B2_1096
4.2.32|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1])-O>>[C&H3&D1:7]-[C&H1&+0&D3:6]1-[O&H0&+0&D2:2]-[C&H0&+0&D3:3](-[c:1])=[N&H0&+0&D2:4]-[C:5]-1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[c:12]1[C:13](=[O:14])[NH:15][CH2:16][CH:17]([CH3:18])O>O.O.CCOCC.O=S(Cl)Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[c:12]1[C:13]1=[N:15][CH2:16][CH:17]([O:14]1)[CH3:18]|US20160002269A1_0268
4.2.20|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-O-C)-O-C.[O&H1&+0&D1:4]-[C:3]-[C:2]-[O&H1&+0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6]1(-[C&H3&D1:5])-[O&H0&+0&D2:4]-[C:3]-[C:2]-[O&H0&+0&D2:1]-1|CO[C:1]([CH3:2])([CH3:3])OC.[OH:4][CH2:5][CH:6]([OH:7])[CH:8]([Cl:9])[CH2:10][OH:11]>O.CC(C)=O.O=S(=O)(O)O.[OH-].[OH-].[Ba+2]>[CH3:2][C:1]1([O:4][CH2:5][CH:6]([O:7]1)[CH:8]([Cl:9])[CH2:10][OH:11])[CH3:3]|US04568491A
1.6.4|[c:9]-[C&H0&+0&D4:8](-[c:7])(-[c:6])-Cl.[c:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H1&+0&D2:1]:1>>[c:9]-[C&H0&+0&D4:8](-[c:7])(-[c:6])-[n&H0&+0&D3:4]1:[c:5]:[n&H0&+0&D2:1]:[c:2]:[c:3]:1|Cl[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[CH3:20][c:21]1[n:22][cH:23][nH:24][c:25]1[CH2:26][OH:27].Cl>CCN(CC)CC.CN(C)C=O>[CH3:20][c:21]1[c:25]([n:24][cH:23][n:22]1[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)[CH2:26][OH:27]|US20060128613A1_0285
4.1.1|[C&H1&+0&D1:6]#[C&H0&+0&D2:5]-[C:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#14](-C)(-C)-C>>[c&H1&+0&D2:6]1:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:5]:1-[C:4]|[CH:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C[Si](C)(C)[N:10]=[N+:11]=[N-:12]>CCOCC>[CH3:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][c:2]1[cH:1][nH:12][n:11][n:10]1|US20200352925A1_0403
4.1.24|[C:6]-[C&H0&+0&D2:5]#[N&H0&+0&D1:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#14](-C)(-C)-C>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]#[N:7].C[Si](C)(C)[N:8]=[N+:9]=[N-:10]>c1ccccc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][n:10][n:9][nH:8]1|EP3757091A1_0351
4.2.17|[N&H2&+0&D1:8]-[c:7]:[c:6]-[O&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:1](:[o&H0&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[OH:8].O=[CH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[OH:16]>[O-][N+](=O)c1ccccc1>[OH:16][c:13]1[cH:12][cH:11][c:10]([cH:15][cH:14]1)-[c:9]1[n:1][c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[o:8]1|US20130102584A1_0319
4.1.58|[C:8]-[C&H0&+0&D3:7](-[C&H0&+0&D3:6](-[C:5])=O)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:6]:1-[C:5]|[NH2:1][c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[NH2:8])[Cl:9])[Cl:10].O=[C:11]([CH2:12][Br:13])[C:14](=O)[CH2:15][Br:16]>>[Cl:10][c:4]1[cH:3][c:2]2[n:1][c:11]([c:14]([n:8][c:7]2[cH:6][c:5]1[Cl:9])[CH2:15][Br:16])[CH2:12][Br:13]|US20090088439A1_0245
1.2.13|[C:8]-[N&H1&+0&D2:7]-[C:6].[C:5]-[C&H1&+0&D3:4]1-[C&H2&+0&D2:3]-[N@@&H0&+0&D3:2]-1-[S:1]>>[C:8]-[N&H0&+0&D3:7](-[C:6])-[C&H2&+0&D2:3]-[C@@&H1&+0&D3:4](-[C:5])-[N&H1&+0&D2:2]-[S:1]|[CH3:1][CH:2]([CH3:3])[C@@H:4]1[CH2:5][C@H:6]([O:7][C:8]1=[O:9])[CH:10]1[CH2:11][N@@:12]1[S:13](=[O:14])(=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[N+:22]([O-:23])=[O:24].[CH3:25][C:26]1([CH2:27][N:28]([C:29]([CH2:30][NH:31]1)=[O:32])[c:33]1[cH:34][cH:35][cH:36][cH:37][c:38]1[Cl:39])[CH3:40]>Cc1ccccc1>[CH3:25][C:26]1([CH2:27][N:28]([C:29]([CH2:30][N:31]1[CH2:11][C@H:10]([NH:12][S:13](=[O:14])(=[O:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[N+:22]([O-:23])=[O:24])[C@@H:6]1[CH2:5][C@H:4]([C:8]([O:7]1)=[O:9])[CH:2]([CH3:1])[CH3:3])=[O:32])[c:33]1[cH:34][cH:35][cH:36][cH:37][c:38]1[Cl:39])[CH3:40]|US08158790B2_1231
4.1.11|[C&H1&+0&D1:8]#[C&H0&+0&D2:7]-[C:6].[S:5]-[N&H1&+0&D2:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c&H1&+0&D2:8]1:[c&H0&+0&D3:7](-[C:6]):[n&H0&+0&D3:4](-[S:5]):[c:3]:[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)I)[NH:11][S:12](=[O:13])(=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[CH:21]#[C:22][CH:23]1[CH2:24][CH2:25][CH2:26][O:27]1>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCN(CC)CC.C1COCCO1.I[Cu].O>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[cH:21][c:22]([n:11]2[S:12](=[O:13])(=[O:14])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[CH:23]1[CH2:24][CH2:25][CH2:26][O:27]1|EP3312172A1_0335
4.2.11|[C&H3&D1:7]-[C&H0&+0&D3:6](=[N&H0&+0&D2:5]-[O&H1&+0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[c:1])-O>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[o&H0&+0&D2:4]:[c&H0&+0&D3:2](:[c:1]):[c:3]:1|[CH3:1][C:2](=[N:3][OH:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1O)[F:11]>O=C(n1ccnc1)n1ccnc1>[CH3:1][c:2]1[n:3][o:4][c:10]2[cH:9][c:8]([cH:7][cH:6][c:5]12)[F:11]|US08334292B1_0270
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[s:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[s:2]|[CH3:1][C:2]1([C:3]([NH:4][c:5]2[cH:6][c:7]([c:8]([cH:9][c:10]21)[NH2:11])[NH2:12])=[O:13])[CH3:14].O=[CH:15][c:16]1[cH:17][cH:18][cH:19][s:20]1>CCO.CC(=O)O>[CH3:1][C:2]1([C:3]([NH:4][c:5]2[cH:6][c:7]3[nH:12][c:15]([n:11][c:8]3[cH:9][c:10]21)-[c:16]1[cH:17][cH:18][cH:19][s:20]1)=[O:13])[CH3:14]|EP2809671B1_0282
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[n:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[n:2]|[CH3:1][C:2]1([C:3]([NH:4][c:5]2[cH:6][c:7]([c:8]([cH:9][c:10]21)[NH2:11])[NH2:12])=[O:13])[CH3:14].O=[CH:15][c:16]1[cH:17][cH:18][cH:19][nH:20]1>Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][C:2]1([C:3]([NH:4][c:5]2[cH:6][c:7]3[nH:12][c:15]([n:11][c:8]3[cH:9][c:10]21)-[c:16]1[cH:17][cH:18][cH:19][nH:20]1)=[O:13])[CH3:14]|US10253023B2_0390
4.1.1|[C&H1&+0&D1:6]#[C&H0&+0&D2:5]-[C:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#14](-C)(-C)-C>>[c&H1&+0&D2:6]1:[n&H0&+0&D2:3]:[n&H1&+0&D2:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:5]:1-[C:4]|[CH:1]#[C:2][C@@H:3]1[CH2:4][C:5]([N:6]1[Si:7]([CH3:8])([CH3:9])[C:10]([CH3:11])([CH3:12])[CH3:13])=[O:14].C[Si](C)(C)[N:15]=[N+:16]=[N-:17]>>[CH3:11][C:10]([CH3:12])([CH3:13])[Si:7]([CH3:8])([CH3:9])[N:6]1[C:5]([CH2:4][C@H:3]1[c:2]1[cH:1][n:17][nH:16][n:15]1)=[O:14]|EP3511328A1_0191
4.3.9|[N&H2&+0&D1:8]-[c:7]:[c:6]-[S&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:1](:[s&H0&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[SH:8].O=[CH:9][c:10]1[cH:11][c:12]([cH:13][cH:14][c:15]1[OH:16])[Br:17]>c1ccncc1>[OH:16][c:15]1[cH:14][cH:13][c:12]([cH:11][c:10]1-[c:9]1[n:1][c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[s:8]1)[Br:17]|US08889881B2_0337
4.1.24|[C:6]-[C&H0&+0&D2:5]#[N&H0&+0&D1:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#50](-C)(-C)-C>>[C:6]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:1|[CH3:1][CH2:2][CH2:3][c:4]1[n:5][c:6]2[c:7]([cH:8][cH:9][n:10][c:11]2[n:12]1[CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20][CH:21]([C:22]#[N:23])[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[CH3:30].C[Sn](C)(C)[N:31]=[N+:32]=[N-:33]>Cc1ccccc1>[CH3:1][CH2:2][CH2:3][c:4]1[n:5][c:6]2[c:7]([cH:8][cH:9][n:10][c:11]2[n:12]1[CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20][CH:21]([c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)[c:22]1[n:23][n:33][n:32][nH:31]1)[CH3:30]|US20160137639A1_3226
4.2.4|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[C:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[O&H1&+0&D1:1]>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:6](-[C:5]):[o&H0&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:3]:1-[C:4]|[CH:1]#[C:2][CH2:3][CH2:4][CH2:5][O:6][c:7]1[c:8]([cH:9][c:10]([cH:11][c:12]1[CH3:13])-[c:14]1[n:15][o:16][c:17]([n:18]1)[CH3:19])[CH3:20].[OH:21][N:22]=[CH:23][CH:24]1[CH2:25][CH2:26]1>O=C1CCC(N1Cl)=O.CCN(CC)CC.c1ccncc1.CN(C)C=O>[CH3:13][c:12]1[cH:11][c:10]([cH:9][c:8]([c:7]1[O:6][CH2:5][CH2:4][CH2:3][c:2]1[cH:1][c:23]([n:22][o:21]1)[CH:24]1[CH2:25][CH2:26]1)[CH3:20])-[c:14]1[n:15][o:16][c:17]([n:18]1)[CH3:19]|US10093683B2_0319
4.1.70|[N&H2&+0&D1:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3]:[c:2]-[C&H1&+0&D2:1]=O)-O>>[n&H0&+0&D2:7]1:[n&H1&+0&D2:6]:[c&H0&+0&D3:4](=[O&H0&D1:5]):[c:3]:[c:2]:[c&H1&+0&D2:1]:1|O.[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[O:9][CH3:10])[C:11](=[O:12])O)[CH:13]=O.[NH2:14][NH2:15]>CCO>[CH3:1][O:2][c:3]1[cH:4][c:5]2[cH:13][n:14][nH:15][c:11]([c:6]2[cH:7][c:8]1[O:9][CH3:10])=[O:12]|US20200207785A1_0184
1.2.3|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[n&H1&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[S:9]([NH2:10])(=[O:11])=[O:12])[C:13](=O)[NH:14][c:15]1[c:16]([nH:17][c:18]([nH:19][c:20]1=[O:21])=[O:22])[NH2:23])[O:24][CH3:25]>>[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[S:9]([NH2:10])(=[O:11])=[O:12])-[c:13]1[n:23][c:16]2[nH:17][c:18]([nH:19][c:20]([c:15]2[nH:14]1)=[O:21])=[O:22])[O:24][CH3:25]|EP0149200A1_0236
4.1.35|[C:8]-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[C:5])=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[C:8]-[c&H0&+0&D3:7]1:[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:6]:1-[C:5]|Cl.[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:5][CH2:6][C:7]([CH2:8][CH2:9]1)=O.N[NH:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[O:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>Cl.CCO>[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:5][c:6]2[c:12]3[cH:13][c:14]([cH:15][cH:16][c:11]3[nH:10][c:7]2[CH2:8][CH2:9]1)[O:17][c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1|US07297704B2_0392
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H1&+0&D2:8]1:[c&H0&+0&D3:1](:[n&H0&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|[NH2:1][c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[NH2:8])[S:9]([NH2:10])(=[O:11])=[O:12])[Cl:13].O=[CH:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CCO.CC(=O)O>[NH2:10][S:9](=[O:11])(=[O:12])[c:5]1[cH:6][c:7]2[nH:8][c:14]([n:1][c:2]2[cH:3][c:4]1[Cl:13])-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US08222248B2_1422
1.2.14|[C:8]-[C&H1&+0&D3:7]1-[O&H0&+0&D2:6]-[C&H1&+0&D3:5]-1-[C:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C:8]-[C@&H1&+0&D3:7](-[N&H0&+0&D3:2](-[C:3])-[C:1])-[C@&H1&+0&D3:5](-[C:4])-[O&H1&+0&D1:6]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]2[CH2:8][CH:9]3[O:10][CH:11]3[CH2:12][c:13]12)[O:14][CH3:15].[CH3:16][O:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[N:24]1[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]1>Cc1ccccc1C.CC(C)O>[CH3:15][O:14][c:6]1[cH:5][cH:4][c:3]([c:13]2[CH2:12][C@H:11]([C@@H:9]([CH2:8][c:7]12)[OH:10])[N:27]1[CH2:28][CH2:29][N:24]([CH2:25][CH2:26]1)[c:23]1[cH:22][cH:21][cH:20][cH:19][c:18]1[O:17][CH3:16])[O:2][CH3:1]|US20160008322A1_0272
1.2.14|[C:8]-[C&H1&+0&D3:7]1-[O&H0&+0&D2:6]-[C&H1&+0&D3:5]-1-[C:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C:8]-[C@&H1&+0&D3:7](-[n&H0&+0&D3:2](:[c:3]):[c:1])-[C@&H1&+0&D3:5](-[C:4])-[O&H1&+0&D1:6]|[cH:1]1[cH:2][nH:3][cH:4][n:5]1.[CH2:6]1[CH2:7][CH2:8][CH:9]2[O:10][CH:11]2[CH2:12]1>O.[O-]C([O-])=O.[K+].[K+]>[OH:10][C@@H:9]1[CH2:8][CH2:7][CH2:6][CH2:12][C@H:11]1[n:3]1[cH:2][cH:1][n:5][cH:4]1|US09908863B2_0233
4.2.20|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-O-C)-O-C.[O&H1&+0&D1:4]-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6]1(-[C&H3&D1:5])-[O&H0&+0&D2:4]-[c:3]:[c:2]-[O&H0&+0&D2:1]-1|[OH:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[OH:8])[OH:9].CO[C:10]([CH3:11])([CH3:12])OC>Cc1ccc(cc1)S(=O)(=O)O.c1ccccc1>[CH3:11][C:10]1([O:9][c:6]2[cH:5][cH:4][cH:3][c:2]([c:7]2[O:8]1)[OH:1])[CH3:12]|EP2774925B1_0295
2.1.2|[C:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-O.[C:5]-[C&H0&+0&D4:4]1(-[N&H2&+0&D1:3])-[C:2]-[C:1]-1>>[C:8]-[C&H0&+0&D3:7](-[N&H1&+0&D2:3]-[C@&H0&+0&D4:4]1(-[C:5])-[C:2]-[C:1]-1)=[O&H0&D1:6]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C@@H:10]([CH2:11][C@H:12]1[C:13](=[O:14])O)[O:15][c:16]1[cH:17][c:18]([n:19][c:20]2[c:21]1[cH:22][cH:23][c:24]([cH:25]2)[O:26][CH3:27])-[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[CH2:34]=[CH:35][CH:36]1[CH2:37][C:38]1([NH2:39])[C:40](=[O:41])[O:42][CH2:43][CH3:44].Cl>CN(C)C(On1nnc2c1cccc2)=[N+](C)C.CC(C)N(CC)C(C)C.F[P-](F)(F)(F)(F)F.ClCCl>[CH2:34]=[CH:35][CH:36]1[CH2:37][C@:38]1([NH:39][C:13](=[O:14])[C@@H:12]1[CH2:11][C@H:10]([CH2:9][N:8]1[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[O:15][c:16]1[cH:17][c:18]([n:19][c:20]2[c:21]1[cH:22][cH:23][c:24]([cH:25]2)[O:26][CH3:27])-[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)[C:40](=[O:41])[O:42][CH2:43][CH3:44]|
4.1.1|[C&H1&+0&D1:6]#[C&H0&+0&D2:5]-[C:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#14](-C)(-C)-C>>[c&H1&+0&D2:6]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:5]:1-[C:4]|[CH:1]#[C:2][CH2:3][CH2:4][N:5]([CH2:6][C:7](=[O:8])[N:9]1[CH2:10][c:11]2[n:12][c:13]([n:14][cH:15][c:16]2[CH2:17]1)[NH:18][CH:19]1[CH2:20][c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[CH2:27]1)[C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34].C[Si](C)(C)[N:35]=[N+:36]=[N-:37]>[O-]C1=C(C(O[C@@H]1[C@@H](O)CO)=O)O.Cc1ccccc1.CCOC(C)=O.CN(C)C=O.O.[Na+]>[CH3:32][C:31]([CH3:33])([CH3:34])[O:30][C:28](=[O:29])[N:5]([CH2:6][C:7](=[O:8])[N:9]1[CH2:10][c:11]2[n:12][c:13]([n:14][cH:15][c:16]2[CH2:17]1)[NH:18][CH:19]1[CH2:20][c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[CH2:27]1)[CH2:4][CH2:3][c:2]1[cH:1][n:37][n:36][nH:35]1|US20200354379A1_0518
4.1.42|[C:7]-[N&H2&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3]-[C&H0&+0&D2:2]#[C&H0&+0&D2:1]-[#14](-C)(-C)-C)-F>>[C:7]-[n&H0&+0&D3:6]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c:3]:[c&H0&+0&D3:4]:1:[c:5]|C[Si](C)(C)[C:1]#[C:2][c:3]1[c:4]([cH:5][cH:6][c:7]([c:8]1[C:9]([F:10])([F:11])[F:12])[C:13]#[N:14])F.[CH3:15][C@H:16]([NH2:17])[C:18]([CH3:19])([CH3:20])[OH:21]>CC(C)N(CC)C(C)C.c1ccc2[nH]ccc2c1.CN1CCCC1=O.Nc1ccccc1.CC(C)(C)[O-].[K+]>[CH3:19][C:18]([CH3:20])([OH:21])[C@H:16]([CH3:15])[n:17]1[cH:1][cH:2][c:3]2[c:8]([c:7]([cH:6][cH:5][c:4]21)[C:13]#[N:14])[C:9]([F:10])([F:11])[F:12]|US10710963B2_0383
4.1.83|[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H2&+0&D1:4].[O&H0&D1:3]=[C&H0&+0&D3:2](-[C&H1&+0&D2:1]=O)-O>>[n&H0&+0&D2:7]1:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](:[n&H1&+0&D2:4]:[c:5]:[c:6]:1)=[O&H0&D1:3]|[NH2:1][c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[NH2:8])[Cl:9])[Cl:10].O=[CH:11][C:12](=[O:13])O>CCO>[O:13]=[c:12]1[cH:11][n:8][c:7]2[cH:6][c:5]([c:4]([cH:3][c:2]2[nH:1]1)[Cl:10])[Cl:9]|EP1000617A2_0328
1.8.15|[S&H0&+0&D1:8]=[c&H0&+0&D3:7](:[n:6]):[n&H1&+0&D2:5]:[c:4].[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[S&H0&+0&D2:8](-[c&H0&+0&D3:2](:[c:3]):[c:1])-[c&H0&+0&D3:7](:[n:6]):[n&H0&+0&D2:5]:[c:4]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][CH2:8][n:9]1[c:10]([s:11][c:12]2[cH:13][c:14]([cH:15][cH:16][c:17]21)[CH:18]([CH3:19])[c:20]1[cH:21][cH:22][n:23]([n:24]1)-[c:25]1[cH:26][cH:27][c:28]([cH:29][n:30]1)I)=[O:31].[CH3:32][n:33]1[cH:34][cH:35][nH:36][c:37]1=[S:38]>C1COCCO1.[OH-].[K+]>[CH3:19][CH:18]([c:14]1[cH:15][cH:16][c:17]2[c:12]([cH:13]1)[s:11][c:10]([n:9]2[CH2:8][O:7][CH2:6][CH2:5][Si:2]([CH3:1])([CH3:3])[CH3:4])=[O:31])[c:20]1[cH:21][cH:22][n:23]([n:24]1)-[c:25]1[cH:26][cH:27][c:28]([cH:29][n:30]1)[S:38][c:37]1[n:36][cH:35][cH:34][n:33]1[CH3:32]|US20140221343A1_0357
3.5.2|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[#12]-Cl.[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[c&H0&+0&D3:2](:[c:3]):[c:1]|Br[c:1]1[cH:2][cH:3][c:4]([n:5][cH:6]1)-[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[CH3:19][C:20]([CH3:21])([CH3:22])[Mg]Cl>C1CCOC1.[C-]#N.[NH4+].[OH-].[Cu+]>[CH3:19][C:20]([CH3:21])([CH3:22])[c:1]1[cH:6][n:5][c:4]([cH:3][cH:2]1)-[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)-[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|EP2935291B1_0134
4.1.12|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Cl)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[c:1]):[c&H1&+0&D2:5]:1|[CH3:1][C:2](=O)[CH2:3]Cl.[NH2:4][c:5]1[n:6][cH:7][cH:8][n:9][c:10]1[Cl:11]>>[CH3:1][c:2]1[cH:3][n:6]2[cH:7][cH:8][n:9][c:10]([c:5]2[n:4]1)[Cl:11]|US20110112135A1_0646
4.1.11|[C&H1&+0&D1:8]#[C&H0&+0&D2:7]-[C:6].[C:5]-[N&H1&+0&D2:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[c&H1&+0&D2:8]1:[c&H0&+0&D3:7](-[C:6]):[n&H0&+0&D3:4](-[C:5]):[c:3]:[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][NH:6][c:7]1[n:8][c:9]([n:10][cH:11][c:12]1Br)[C:13]#[N:14].[CH:15]#[C:16][CH2:17][n:18]1[cH:19][cH:20][n:21][cH:22]1>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCN(CC)CC.CCOC(C)=O.CN(C)C=O.I[Cu].O>[CH3:1][C:2]([CH3:3])([CH3:4])[CH2:5][n:6]1[c:16]([cH:15][c:12]2[c:7]1[n:8][c:9]([n:10][cH:11]2)[C:13]#[N:14])[CH2:17][n:18]1[cH:19][cH:20][n:21][cH:22]1|US20060247251A1_0366
1.2.14|[C:8]-[N&H1&+0&D2:7]-[C:6].[C:5]-[C&H1&+0&D3:4]1-[O&H0&+0&D2:3]-[C&H1&+0&D3:2]-1-[c:1]>>[C:8]-[N&H0&+0&D3:7](-[C:6])-[C@&H1&+0&D3:2](-[c:1])-[C@@&H1&+0&D3:4](-[C:5])-[O&H1&+0&D1:3]|[ClH:1].[CH3:2][C:3]1([O:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[CH:11]2[O:12][CH:13]21)[C:14]#[N:15])[CH3:16].[CH2:17]1[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]1>CCO>[ClH:1].[CH3:2][C:3]1([O:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[C@H:11]([C@@H:13]1[OH:12])[N:20]1[CH2:19][CH2:18][CH2:17][CH2:22][CH2:21]1)[C:14]#[N:15])[CH3:16]|EP0344747A1_0105
1.3.6|[C:8]-[C&H0&+0&D3:7](=[N&H0&+0&D2:6]-[c:5]:[c&H0&+0&D3:4](:[c:3])-Br)-[N&H1&+0&D2:2]-[C:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c:5]:[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D3:2]:1-[C:1]|[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[CH:8]1[CH2:9][CH2:10][C:11]([NH:12]1)=[N:13][c:14]1[cH:15][cH:16][c:17]([cH:18][c:19]1Br)[Cl:20]>>[F:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[CH:8]1[CH2:9][CH2:10][c:11]2[n:13][c:14]3[cH:15][cH:16][c:17]([cH:18][c:19]3[n:12]21)[Cl:20]|US09856253B2_2022
1.3.6|[C:8]-[C&H0&+0&D3:7](=[N&H0&+0&D2:6]-[c:5]:[c&H0&+0&D3:4](:[n:3])-Br)-[N&H1&+0&D2:2]-[C:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c:5]:[c&H0&+0&D3:4](:[n:3]):[n&H0&+0&D3:2]:1-[C:1]|[Br:1][c:2]1[cH:3][cH:4][c:5]([c:6]([n:7]1)Br)[N:8]=[C:9]1[CH2:10][CH2:11][CH:12]([NH:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]2[n:8][c:9]3[CH2:10][CH2:11][CH:12]([n:13]3[c:6]2[n:7]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US09856253B2_1886
4.1.12|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Cl)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[n:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[n:1]):[c&H1&+0&D2:5]:1|[CH3:1][C:2](=O)[CH2:3]Cl.[CH3:4][c:5]1[cH:6][c:7]([c:8]([n:9][n:10]1)[NH2:11])[CH:12]([CH2:13][CH3:14])[CH2:15][CH3:16]>CCO.O=C(O)O[Na]>[CH3:16][CH2:15][CH:12]([CH2:13][CH3:14])[c:7]1[cH:6][c:5]([n:10][n:9]2[cH:3][c:2]([n:11][c:8]12)[CH3:1])[CH3:4]|US20200165256A1_0450
4.3.9|[C&H3&D1:7]-[C&H0&+0&D3:6](=[S&H0&+0&D1:5])-[N&H1&+0&D2:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-Br>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:5]:[c&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:1|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[Br:8])[NH:9][C:10]([CH3:11])=[S:12])Br>COCCOC.O=C(O[Cs])O[Cs].I[Cu].c1ccc2ccc3cccnc3c2n1>[CH3:1][c:2]1[cH:7][c:6]([c:5]2[n:9][c:10]([s:12][c:4]2[cH:3]1)[CH3:11])[Br:8]|EP2881397B1_0067
4.1.12|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Br)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[c:1]):[c&H1&+0&D2:5]:1|[CH3:1][C:2](=O)[CH2:3]Br.[NH2:4][c:5]1[n:6][cH:7][cH:8][cH:9][c:10]1[CH:11]=[O:12]>O.Cl.COCCOC.CCO>[CH3:1][c:2]1[cH:3][n:6]2[cH:7][cH:8][cH:9][c:10]([c:5]2[n:4]1)[CH:11]=[O:12]|US20150057260A1_0782
8.2.1|[O&H1&+0&D1:8]-O.[c:7]:[c&H0&+0&D3:6]1:[c:5]:[s&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1]>>[O&H0&+0&D1:8]=[S&H0&+0&D3:4]1-[c:5]:[c&H0&+0&D3:6](:[c:7])-[c&H0&+0&D3:2](:[c:1]):[c:3]-1|[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10][O:11][C:12](=[O:13])[NH:14][c:15]1[cH:16][cH:17][c:18]2[s:19][c:20]3[cH:21][cH:22][cH:23][cH:24][c:25]3[c:26]2[cH:27]1.[OH:28]O>CC(=O)O>[O-:1][N+:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[CH2:10][O:11][C:12](=[O:13])[NH:14][c:15]1[cH:16][cH:17][c:18]2[c:26]([cH:27]1)-[c:25]1[cH:24][cH:23][cH:22][cH:21][c:20]1[S:19]2=[O:28]|US20180201604A1_0334
1.7.13|[C:8]-[C@&H1&+0&D3:7](-[O:6])-Br.[O&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[n:1]>>[C:8]-[C@&H1&+0&D3:7](-[O&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[n:1])-[O:6]|[CH3:1][c:2]1[nH:3][nH:4][c:5]([c:6]1[CH2:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[O:14][CH:15]([CH3:16])[CH3:17])=[O:18].[CH3:19][C:20](=[O:21])[O:22][CH2:23][C@H:24]1[O:25][C@@H:26]([C@@H:27]([C@H:28]([C@@H:29]1[O:30][C:31]([CH3:32])=[O:33])[O:34][C:35]([CH3:36])=[O:37])[O:38][C:39]([CH3:40])=[O:41])Br>[O-]C([O-])=O.C1CCOC1.[Ag+].[Ag+]>[CH3:16][CH:15]([CH3:17])[O:14][c:11]1[cH:12][cH:13][c:8]([cH:9][cH:10]1)[CH2:7][c:6]1[c:2]([nH:3][n:4][c:5]1[O:18][C@@H:26]1[O:25][C@@H:24]([C@H:29]([C@@H:28]([C@H:27]1[O:38][C:39]([CH3:40])=[O:41])[O:34][C:35]([CH3:36])=[O:37])[O:30][C:31]([CH3:32])=[O:33])[CH2:23][O:22][C:20]([CH3:19])=[O:21])[CH3:1]|EP1864993A1_0084
4.3.6|[C:7]-[C&H2&+0&D2:6]-[S&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-[N&+](-[O&-])=O>>[C:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:5]:[c&H0&+0&D3:3](:[c:4]):[c:2]:[c&H1&+0&D2:1]:1|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[N+]([O-])=O)[CH:9]=O.[CH3:10][O:11][C:12](=[O:13])[CH2:14][SH:15]>O=C(O[K])O[K]>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[cH:9][c:14]([s:15][c:8]12)[C:12](=[O:13])[O:11][CH3:10]|US10562912B2_0714
4.3.11|[S&H0&+0&D1:6]=[C&H0&+0&D3:5](-[N&H1&+0&D2:4]-C(-C)(-C)-C)-[N&H1&+0&D2:3]-[C:2]-[C&H2&+0&D2:1]-O>>[S&H0&+0&D2:6]1-[C&H2&+0&D2:1]-[C:2]-[N&H0&+0&D2:3]=[C&H0&+0&D3:5]-1-[N&H2&+0&D1:4]|[ClH:1].CC(C)(C)[NH:2][C:3](=[S:4])[NH:5][CH:6]([CH2:7]O)[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[Br:14]>>[ClH:1].[NH2:2][C:3]1=[N:5][CH:6]([CH2:7][S:4]1)[c:8]1[cH:13][c:12]([cH:11][cH:10][cH:9]1)[Br:14]|US20020022631A1_0354
4.2.17|[N&H2&+0&D1:8]-[c:7]:[c:6]-[O&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[n:2])-[C&H0&+0&D3:1](-O)=O>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[o&H0&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[n:2]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[OH:8].O=[C:9](O)[c:10]1[cH:11][cH:12][cH:13][cH:14][n:15]1>O.O=P(O)(O)O.O[Na]>[cH:3]1[cH:4][cH:5][cH:6][c:7]2[o:8][c:9]([n:1][c:2]12)-[c:10]1[cH:11][cH:12][cH:13][cH:14][n:15]1|EP2526129B1_0062
4.3.6|[C:8]-[C&H2&+0&D2:7]-[S&H1&+0&D1:6].[C:5]-[C&H0&+0&D3:4](-[c:3]:[c&H0&+0&D3:2](:[c:1])-F)=O>>[C:8]-[c&H0&+0&D3:7]1:[s&H0&+0&D2:6]:[c&H0&+0&D3:2](:[c:1]):[c:3]:[c&H0&+0&D3:4]:1-[C:5]|[CH3:1][C:2](=[O:3])[N:4]1[CH2:5][CH2:6][CH:7]([CH2:8][CH2:9]1)[C:10](=O)[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1F)[F:17].[CH3:18][O:19][C:20](=[O:21])[CH2:22][SH:23]>C1CCOC1.[NaH]>[CH3:18][O:19][C:20](=[O:21])[c:22]1[s:23][c:16]2[cH:15][c:14]([cH:13][cH:12][c:11]2[c:10]1[CH:7]1[CH2:8][CH2:9][N:4]([CH2:5][CH2:6]1)[C:2]([CH3:1])=[O:3])[F:17]|EP3643711A1_0226
2.2.3|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C&H3&D1:5].[C:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C&H3&D1:5])-[S&H0&+0&D4:3](-[C:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[CH2:14][S:15](=[O:16])(=[O:17])Cl.[CH3:18][NH:19][CH3:20]>Cl.CCO.ClCCl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[CH2:14][S:15](=[O:16])(=[O:17])[N:19]([CH3:18])[CH3:20]|US20190382354A1_0325
3.7.3|[C&H3&D1:7]-[C&H1&+0&D3:6](-[C&H3&D1:5])-[#12]-Cl.[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&D1:7]-[C&H1&+0&D3:6](-[C&H3&D1:5])-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[O&H1&+0&D1:1]|[CH3:1][CH:2]([CH3:3])[Mg]Cl.[N:4]#[C:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[O:18][CH2:19][CH2:20][CH2:21][N:22]1[CH2:23][CH2:24][C:25]([CH2:26]1)=[O:27]>C1CCOC1>[CH3:1][CH:2]([CH3:3])[C:25]1([CH2:24][CH2:23][N:22]([CH2:26]1)[CH2:21][CH2:20][CH2:19][O:18][c:15]1[cH:16][cH:17][c:12]([cH:13][cH:14]1)-[c:9]1[cH:10][cH:11][c:6]([cH:7][cH:8]1)[C:5]#[N:4])[OH:27]|EP1937407B1_0051
4.1.16|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[s:2])-[C&H0&+0&D3:1](-O)=O>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[n&H1&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[s:2]|[CH3:1][S:2][c:3]1[cH:4][c:5]([c:6]([s:7]1)[C:8](=O)O)[O:9][CH3:10].[NH2:11][c:12]1[cH:13][cH:14][cH:15][n:16][c:17]1[NH2:18]>N.O.CO.O=P(Cl)(Cl)Cl>[CH3:10][O:9][c:5]1[cH:4][c:3]([s:7][c:6]1-[c:8]1[n:18][c:17]2[n:16][cH:15][cH:14][cH:13][c:12]2[nH:11]1)[S:2][CH3:1]|US20080139558A1_0466
4.1.11|[#14:8]-[C&H0&+0&D2:7]#[C&H0&+0&D2:6]-[C:5].[N&H2&+0&D1:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[#14:8]-[c&H0&+0&D3:7]1:[n&H1&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([CH3:6])([CH3:7])[O:8][CH2:9][CH2:10][CH2:11][C:12]#[C:13][Si:14]([CH3:15])([CH3:16])[CH3:17].[CH3:18][NH:19][S:20](=[O:21])(=[O:22])[CH2:23][c:24]1[cH:25][cH:26][c:27]([c:28]([cH:29]1)I)[NH2:30]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCCC[N+](CCCC)(CCCC)CCCC.O=C(O[Na])O[Na].CN(C)C=O.CC([O-])=O.CC([O-])=O.[Cl-].[Pd+2]>[CH3:18][NH:19][S:20](=[O:21])(=[O:22])[CH2:23][c:24]1[cH:25][cH:26][c:27]2[nH:30][c:13]([c:12]([c:28]2[cH:29]1)[CH2:11][CH2:10][CH2:9][O:8][Si:5]([CH3:6])([CH3:7])[C:2]([CH3:1])([CH3:3])[CH3:4])[Si:14]([CH3:15])([CH3:16])[CH3:17]|EP3190109B1_0263
4.1.13|[C&H3&D1:7]-[C&H0&+0&D3:6](-[c:5]:[c&H0&+0&D3:4](:[c:3])-F)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](:[c:3]):[c:5]:1|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1F)[F:9].[NH2:10][NH2:11]>CCO>[CH3:1][c:2]1[n:10][nH:11][c:8]2[cH:7][c:6]([cH:5][cH:4][c:3]12)[F:9]|US20200095261A1_0260
2.2.3|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C&H3&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C&H3&D1:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[S:10](=[O:11])(=[O:12])Cl)[Cl:13].[CH3:14][NH:15][CH3:16]>O.CO>[CH3:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[S:10](=[O:11])(=[O:12])[N:15]([CH3:14])[CH3:16])[Cl:13]|EP1844020B1_0268
4.1.40|[N&H2&+0&D1:7]-[c:6]:[c:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O-C.[N&H2&+0&D1:2]-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:7]1:[c&H1&+0&D2:1]:[n&H1&+0&D2:2]:[c&H0&+0&D3:4](=[O&H0&D1:3]):[c:5]:[c:6]:1|CO[C:1](=[O:2])[c:3]1[cH:4][c:5]2[O:6][CH2:7][CH2:8][O:9][c:10]2[cH:11][c:12]1[NH2:13].[NH2:14][CH:15]=O>>[O:2]=[c:1]1[nH:14][cH:15][n:13][c:12]2[cH:11][c:10]3[O:9][CH2:8][CH2:7][O:6][c:5]3[cH:4][c:3]21|US20180360837A1_0136
4.1.16|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[n:2])-[C&H0&+0&D3:1](-O)=O>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[n&H1&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[n:2]|[CH3:1][c:2]1[cH:3][n:4][c:5]([cH:6][cH:7]1)[C:8](=O)O.[NH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[NH2:16]>O.O=C(O[Na])O[Na].O=P(O)(O)O>[CH3:1][c:2]1[cH:7][cH:6][c:5]([n:4][cH:3]1)-[c:8]1[n:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[nH:16]1|US07205403B2_0263
4.1.16|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-O)=O>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[n&H1&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][n:7]1)[C:8](=O)O.[NH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[NH2:16]>O.O=C(O[Na])O[Na].O=P(O)(O)O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][n:7]1)-[c:8]1[n:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[nH:16]1|US06627111B2
4.2.17|[N&H2&+0&D1:8]-[c:7]:[c:6]-[O&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-O)=O>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[o&H0&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2]|Cl.[NH2:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[OH:8])[Cl:9])[Cl:10].O=[C:11](O)[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[OH:18]>OB(O)O.O[Na].Clc1ccccc1Cl>[OH:18][c:16]1[cH:15][cH:14][cH:13][c:12]([cH:17]1)-[c:11]1[n:1][c:2]2[cH:3][c:4]([cH:5][c:6]([c:7]2[o:8]1)[Cl:9])[Cl:10]|US09221770B2_0175
2.2.3|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C:5].[C&H3&D1:4]-[S&H0&+0&D4:3](=[O&H0&D1:2])(=[O&H0&D1:1])-Cl>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C:5])-[S&H0&+0&D4:3](-[C&H3&D1:4])(=[O&H0&D1:2])=[O&H0&D1:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1=[C:7]([NH:8][C:9](=[C:10]([CH:11]1[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18])[C:19](=[O:20])[O:21][CH3:22])[CH3:23])[CH2:24][O:25][CH2:26][CH2:27][NH:28][CH3:29].[CH3:30][S:31](=[O:32])(=[O:33])Cl>CCN(CC)CC.ClCCl.O.O>[CH3:22][O:21][C:19](=[O:20])[C:10]1=[C:9]([NH:8][C:7](=[C:6]([CH:11]1[c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[Cl:18])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[CH2:24][O:25][CH2:26][CH2:27][N:28]([CH3:29])[S:31]([CH3:30])(=[O:32])=[O:33])[CH3:23]|US20200347090A1_1458
4.1.62|[N&H2&+0&D1:7]-[c:6]:[c:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O-C.[N&H2&+0&D1:2]-[C&H1&+0&D2:1]=N>>[n&H0&+0&D2:7]1:[c&H1&+0&D2:1]:[n&H1&+0&D2:2]:[c&H0&+0&D3:4](=[O&H0&D1:3]):[c:5]:[c:6]:1|CC(=O)O.[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[C:9](=[O:10])OC)[NH2:11])[O:12][CH3:13].N=[CH:14][NH2:15]>COCCO>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]2[n:11][cH:14][nH:15][c:9]([c:8]12)=[O:10])[O:12][CH3:13]|US20030144308A1_0164
2.2.3|[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-Cl.[C&H3&D1:3]-[N&H1&+0&D2:2]-[c:1]>>[C&H3&D1:7]-[S&H0&+0&D4:6](=[O&H0&D1:5])(=[O&H0&D1:4])-[N&H0&+0&D3:2](-[C&H3&D1:3])-[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][c:8]([c:9]([cH:10][c:11]1[C:12](=[O:13])[O:14][CH2:15][CH3:16])[NH:17][CH3:18])[CH3:19].[CH3:20][S:21](=[O:22])(=[O:23])Cl>CCCC[Li].C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][c:8]([c:9]([cH:10][c:11]1[C:12](=[O:13])[O:14][CH2:15][CH3:16])[N:17]([CH3:18])[S:21]([CH3:20])(=[O:22])=[O:23])[CH3:19]|US20110295005A1_0054
4.1.7|[C&H2&+0&D1:7]=[C&H1&+0&D2:6]-[C&H1&+0&D2:5]=O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[c&H1&+0&D2:7]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H1&+0&D2:5]:[c&H1&+0&D2:6]:1|[CH2:1]=[CH:2][CH:3]=O.[NH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[N:11]1[CH2:12][CH2:13][CH2:14][C:15]1=[O:16]>N.O.O=S(=O)(O)O.O=[As+3]>[O:16]=[C:15]1[CH2:14][CH2:13][CH2:12][N:11]1[c:10]1[cH:9][cH:8][cH:7][c:6]2[cH:3][cH:2][cH:1][n:4][c:5]12|US20170015677A1_0634
4.1.34|[C:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[S:5])=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[C:8]-[c&H0&+0&D3:7]1:[c&H0&+0&D3:6](-[S:5]):[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:1|[CH3:1][O:2][C:3](=[O:4])[C:5]([CH3:6])([CH3:7])[CH2:8][C:9](=O)[CH2:10][S:11][C:12]([CH3:13])([CH3:14])[CH3:15].[CH3:16][O:17][c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[NH:24]N.Cl>CC(C)(C)O>[CH3:16][O:17][c:18]1[cH:19][cH:20][c:21]2[c:10]([c:9]([nH:24][c:22]2[cH:23]1)[CH2:8][C:5]([CH3:6])([CH3:7])[C:3](=[O:4])[O:2][CH3:1])[S:11][C:12]([CH3:13])([CH3:14])[CH3:15]|US20100298343A1_0690
4.2.17|[N&H2&+0&D1:8]-[c:7]:[c:6]-[O&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-Cl)=O>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[o&H0&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[OH:8])[NH2:9].O=[C:10](Cl)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>c1ccncc1>[CH3:1][c:2]1[cH:3][cH:4][c:5]2[n:9][c:10]([o:8][c:6]2[cH:7]1)-[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US20200299277A1_1082
4.1.12|[C:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-Cl)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH2:2][C:3](=O)[CH:4](Cl)[C:5](=[O:6])[O:7][CH3:8].[NH2:9][c:10]1[n:11][cH:12][cH:13][n:14][c:15]1[Cl:16]>>[CH3:8][O:7][C:5](=[O:6])[c:4]1[c:3]([n:9][c:10]2[c:15]([n:14][cH:13][cH:12][n:11]12)[Cl:16])[CH2:2][CH3:1]|US20170050961A1_1090
4.2.19|[C&H2&+0&D1:8]=[C&H0&+0&D3:7](-[C:6])-[c:5].[O&H1&+0&D1:4]-[N:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H2&+0&D2:8]1-[C&H0&+0&D3:2](-[c:1])=[N:3]-[O&H0&+0&D2:4]-[C&H0&+0&D4:7]-1(-[C:6])-[c:5]|[CH2:1]=[C:2]([c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[Cl:9])[Cl:10])[C:11]([F:12])([F:13])[F:14].[CH3:15][c:16]1[cH:17][c:18]([cH:19][cH:20][c:21]1[Br:22])[C:23](Cl)=[N:24][OH:25]>C1CCOC1.[O-]C(=O)O.[K+]>[CH3:15][c:16]1[cH:17][c:18]([cH:19][cH:20][c:21]1[Br:22])[C:23]1[CH2:1][C:2]([O:25][N:24]=1)([c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[Cl:9])[Cl:10])[C:11]([F:12])([F:13])[F:14]|US20200178531A1_0611
4.1.13|[C&H3&D1:7]-[C&H0&+0&D3:6](-[c:5]:[c&H0&+0&D3:4](:[n:3])-Cl)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](:[n:3]):[c:5]:1|[CH3:1][C:2](=O)[c:3]1[c:4]([n:5][c:6]([n:7][c:8]1Cl)[NH2:9])[Cl:10].[NH2:11][NH2:12]>ClCCl>[CH3:1][c:2]1[n:12][nH:11][c:8]2[n:7][c:6]([n:5][c:4]([c:3]12)[Cl:10])[NH2:9]|US20180201609A1_0387
4.2.19|[C&H2&+0&D1:8]=[C&H0&+0&D3:7](-[C:6])-[C:5].[C:4]-[C&H0&+0&D3:3](=[N:2]-[O&H1&+0&D1:1])-Cl>>[C&H2&+0&D2:8]1-[C&H0&+0&D3:3](-[C:4])=[N:2]-[O&H0&+0&D2:1]-[C&H0&+0&D4:7]-1(-[C:6])-[C:5]|[CH3:1][CH:2]([CH3:3])[C@H:4]([NH:5][C:6](=[O:7])[O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[C:16](Cl)=[N:17][OH:18].[CH2:19]=[C:20]([CH2:21][O:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:29](=[O:30])[O:31][CH2:32][CH3:33]>CCN(CC)CC.CCOCC.O>[CH3:1][CH:2]([CH3:3])[C@H:4]([NH:5][C:6](=[O:7])[O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[C:16]1[CH2:19][C:20]([O:18][N:17]=1)([CH2:21][O:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[C:29](=[O:30])[O:31][CH2:32][CH3:33]|US09605000B2_2071
4.1.12|[C:8]-[C&H1&+0&D3:7](-[C&H0&+0&D3:6](-[C:5])=O)-Br.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Br)[C:7](=O)[C:8](=[O:9])[O:10][CH2:11][CH3:12].[NH2:13][c:14]1[cH:15][cH:16][cH:17][n:18][c:19]1[NH2:20]>COCCOC.O=C(O[Na])O[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:20][c:19]2[c:14]([cH:15][cH:16][cH:17][n:18]12)[NH2:13])[C:8](=[O:9])[O:10][CH2:11][CH3:12]|US20150284385A1_0291
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-Cl)=O>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[n&H1&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2]|Cl.Cl.[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[O:9][CH3:10])[C:11](=O)Cl.[NH2:12][c:13]1[n:14][cH:15][n:16][cH:17][c:18]1[NH2:19]>CCO.O=P(Cl)(Cl)Cl>[CH3:10][O:9][c:7]1[cH:8][c:3]([cH:4][cH:5][c:6]1-[c:11]1[n:12][c:13]2[n:14][cH:15][n:16][cH:17][c:18]2[nH:19]1)[S:2][CH3:1]|US20190241558A1_0708
4.2.19|[C&H2&+0&D1:8]=[C&H0&+0&D3:7](-[C:6])-[C:5].[O&H1&+0&D1:4]-[N:3]=[C&H0&+0&D3:2](-[c:1])-Cl>>[C&H2&+0&D2:8]1-[C&H0&+0&D3:2](-[c:1])=[N:3]-[O&H0&+0&D2:4]-[C&H0&+0&D4:7]-1(-[C:6])-[C:5]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[C:8](Cl)=[N:9][OH:10])[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[CH2:19]=[C:20]([CH2:21][C:22](=[O:23])[O:24][CH3:25])[C:26](=[O:27])[O:28][CH3:29]>CCN(CC)CC.C1CCOC1.O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[C:8]1[CH2:19][C:20]([O:10][N:9]=1)([CH2:21][C:22](=[O:23])[O:24][CH3:25])[C:26](=[O:27])[O:28][CH3:29])[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US20060116400A1_0540
4.1.16|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H1&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[c:2].[C&H1&+0&D2:1](-O)=O>>[n&H0&+0&D2:8]1:[c&H1&+0&D2:1]:[n&H0&+0&D3:5](:[c:6]:[c:7]:1)-[c&H0&+0&D3:4](:[c:3]):[c:2]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[NH2:9])[NH:10][c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[I:17].O=[CH:18]O>>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[n:9][cH:18][n:10]2-[c:11]1[cH:16][c:15]([cH:14][cH:13][cH:12]1)[I:17]|US10647680B2_0462
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H1&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n:2].[C&H1&+0&D2:1](=N)-N>>[n&H0&+0&D2:8]1:[c&H1&+0&D2:1]:[n&H0&+0&D3:5](:[c:6]:[c:7]:1)-[c&H0&+0&D3:4](:[c:3]):[n:2]|[CH3:1][c:2]1[n:3][c:4]([n:5][c:6]([c:7]1[NH2:8])[NH:9][c:10]1[cH:11][c:12]([nH:13][n:14]1)[CH:15]1[CH2:16][CH2:17]1)[NH:18][C@@H:19]([CH2:20][OH:21])[c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28].CC(=O)O.N=[CH:29]N>CCO>[CH3:1][c:2]1[n:3][c:4]([n:5][c:6]2[c:7]1[n:8][cH:29][n:9]2-[c:10]1[cH:11][c:12]([nH:13][n:14]1)[CH:15]1[CH2:16][CH2:17]1)[NH:18][C@@H:19]([CH2:20][OH:21])[c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28]|US20120122892A1_0258
1.2.14|[C:8]-[C@@&H0&+0&D4:7]1(-[c:6])-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:8]-[C@@&H0&+0&D4:7](-[c:6])(-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:3]):[n:1])-[O&H1&+0&D1:4]|[CH3:1][C@@H:2]([n:3]1[n:4][cH:5][n:6][n:7]1)[C@:8]1([CH2:9][O:10]1)[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[F:17])[F:18].[cH:19]1[n:20][cH:21][nH:22][n:23]1>O.CCOC(C)=O.CN(C)C=O.[NaH]>[CH3:1][C@@H:2]([n:3]1[n:4][cH:5][n:6][n:7]1)[C@:8]([OH:10])([CH2:9][n:22]1[cH:21][n:20][cH:19][n:23]1)[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[F:17])[F:18]|EP0548553A1_0205
4.1.59|[N&H0&+0&D1:7]#[C&H0&+0&D2:6]-[c:5]:[c&H0&+0&D3:4](:[c:3])-F.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[N&H2&+0&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](:[c:3]):[c:5]:1|[N:1]#[C:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1F)[CH2:9][N:10]1[C:11]([N:12]([C@@H:13]([C@@H:14]([C@H:15]([C@H:16]1[CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[OH:24])[OH:25])[CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)=[O:40].[NH2:41][NH2:42]>O.CCOC(C)=O.CC(C)O.[O-]C([O-])=O.[Ca+2]>[NH2:1][c:2]1[n:41][nH:42][c:8]2[c:3]1[cH:4][c:5]([cH:6][cH:7]2)[CH2:9][N:10]1[C:11]([N:12]([C@@H:13]([C@@H:14]([C@H:15]([C@H:16]1[CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[OH:24])[OH:25])[CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[CH2:33][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)=[O:40]|US08324231B2_0271
1.7.11|[O&H1&+0&D1:8]-[c:7]:[c&H0&+0&D3:6](:[c:5])-[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2](:[c:1])-F>>[o&H0&+0&D2:8]1:[c:7]:[c&H0&+0&D3:6](:[c:5]):[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][cH:6][c:7]([c:8]([c:9]1[F:10])[OH:11])-[c:12]1[cH:13][c:14]([c:15]([c:16]([c:17]1F)[F:18])[F:19])[CH2:20][CH2:21][CH3:22]>CS(C)=O.[NaH]>[CH3:22][CH2:21][CH2:20][c:14]1[cH:13][c:12]2[c:7]3[cH:6][cH:5][c:4]([c:9]([c:8]3[o:11][c:17]2[c:16]([c:15]1[F:19])[F:18])[F:10])[CH2:3][CH2:2][CH3:1]|US20190393420A1_0400
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[n:2])-[C&H0&+0&D3:1](=N)-O-C>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[n&H1&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[n:2]|CO[C:1](=N)[c:2]1[cH:3][cH:4][cH:5][cH:6][n:7]1.[NH2:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[NH2:15])[CH:16]([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[n:23]1[cH:24][n:25][cH:26][cH:27]1>CC(=O)O>[cH:26]1[cH:27][n:23]([cH:24][n:25]1)[CH:16]([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:12]1[cH:13][c:14]2[n:15][c:1]([nH:8][c:9]2[cH:10][cH:11]1)-[c:2]1[cH:3][cH:4][cH:5][cH:6][n:7]1|US09296745B2_0683
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H1&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[c:2].[C&H1&+0&D2:1](-N)=N>>[n&H0&+0&D2:8]1:[c&H1&+0&D2:1]:[n&H0&+0&D3:5](:[c:6]:[c:7]:1)-[c&H0&+0&D3:4](:[c:3]):[c:2]|CC(=O)O.[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[NH:14][C:15](=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[NH:23][c:24]1[cH:25][cH:26][cH:27][cH:28][c:29]1[NH2:30].N=[CH:31]N>O.COCCO.CCOC(C)=O.CC([O-])=O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[NH:14][C:15](=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)-[n:23]1[cH:31][n:30][c:29]2[cH:28][cH:27][cH:26][cH:25][c:24]21|EP2172454A1_0148
4.2.3|[C:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[N&H1&+0&D2:3]-[N&H2&+0&D1:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[C:6]-[c&H0&+0&D3:5]1:[o&H0&+0&D2:4]:[c&H1&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D2:3]:1|[NH2:1][NH:2][C:3](=[O:4])[CH2:5][S:6](=[O:7])(=[O:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.CO[CH:15](OC)OC>O=P(Cl)(Cl)Cl>[O:7]=[S:6](=[O:8])([CH2:5][c:3]1[n:2][n:1][cH:15][o:4]1)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US20070259874A1_0230
4.1.118|[N&H2&+0&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-N.[N&H2&+0&D1:4]-[c:3]:[c:2]-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:7]1:[c&H1&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[O&H1&+0&D1:5]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([c:8]1[NH2:9])[CH:10]=O.N[C:11]([NH2:12])=[O:13]>[NH4+].CC([O-])=O>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[cH:10][n:12][c:11]([n:9][c:8]12)[OH:13]|US20200165256A1_0437
1.3.2|[N&H2&+0&D1:8]-[c:7]:[c&H0&+0&D3:6](:[c:5])-[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2](:[c:1])-Cl>>[n&H1&+0&D2:8]1:[c:7]:[c&H0&+0&D3:6](:[c:5]):[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][c:2]1[n:3][cH:4][c:5]([c:6]([c:7]1Cl)-[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[NH2:14])[C@@H:15]1[CH2:16][CH2:17][CH2:18][N:19]1[CH3:20]>O=C(O[Cs])O[Cs].C1CCC(CC1)PC1CCCCC1.[Pd]>[CH3:20][N:19]1[CH2:18][CH2:17][CH2:16][C@H:15]1[c:5]1[cH:4][n:3][c:2]([c:7]2[nH:14][c:13]3[cH:12][cH:11][cH:10][cH:9][c:8]3[c:6]12)[CH3:1]|US20120208809A1_0626
4.1.59|[N&H0&+0&D1:7]#[C&H0&+0&D2:6]-[c:5]:[c&H0&+0&D3:4](:[c:3])-Cl.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[N&H2&+0&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](:[c:3]):[c:5]:1|O.[N:1]#[C:2][c:3]1[cH:4][n:5][c:6]2[c:7]([cH:8][cH:9][cH:10][c:11]2[c:12]1Cl)[NH:13][C:14](=[O:15])[c:16]1[c:17]([cH:18][cH:19][cH:20][c:21]1[Cl:22])[Cl:23].[NH2:24][NH2:25]>O.CN1CCCC1=O>[NH2:1][c:2]1[n:24][nH:25][c:12]2[c:11]3[cH:10][cH:9][cH:8][c:7]([c:6]3[n:5][cH:4][c:3]12)[NH:13][C:14](=[O:15])[c:16]1[c:17]([cH:18][cH:19][cH:20][c:21]1[Cl:22])[Cl:23]|US09233979B2_0583
4.1.47|[c:8]:[c&H0&+0&D3:7](:[c:6])-[N&H0&+0&D2:5]=[N&H0&+0&D2:4]-[c:3]:[c:2]-[N&H0&+&D3:1](-[O&-])=O>>[c:8]:[c&H0&+0&D3:7](:[c:6])-[n&H0&+0&D3:5]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D2:1]:1|[CH3:1][CH2:2][C:3]([CH3:4])([CH3:5])[c:6]1[cH:7][c:8]([c:9]([c:10]([cH:11]1)[C:12]([CH3:13])([CH3:14])[CH2:15][CH3:16])[OH:17])[N:18]=[N:19][c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1[N+:26]([O-])=O>O.CC(C)O.[O-][N+](=O)c1ccccc1N=Nc1ccccc1.O[Na].[Zn]>[CH3:1][CH2:2][C:3]([CH3:4])([CH3:5])[c:6]1[cH:11][c:10]([c:9]([c:8]([cH:7]1)-[n:18]1[n:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[n:26]1)[OH:17])[C:12]([CH3:13])([CH3:14])[CH2:15][CH3:16]|EP2346840B1_0034
4.1.59|[N&H0&+0&D1:7]#[C&H0&+0&D2:6]-[c:5]:[c&H0&+0&D3:4](:[n:3])-Cl.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[N&H2&+0&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](:[n:3]):[c:5]:1|O.[N:1]#[C:2][c:3]1[c:4]([cH:5][c:6]([n:7][c:8]1Cl)[N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1)-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[NH2:21][NH2:22]>O.OCCO>[NH2:1][c:2]1[n:21][nH:22][c:8]2[n:7][c:6]([cH:5][c:4]([c:3]12)-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1|US20200339564A1_0342
4.2.4|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[C:4]/[C&H0&+0&D3:3](=[N&H0&+0&D2:2]\[O&H1&+0&D1:1])-Cl>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:6](-[C:5]):[o&H0&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:3]:1-[C:4]|[CH:1]#[C:2][CH2:3][NH:4][C:5](=[O:6])[O:7][C:8]([CH3:9])([CH3:10])[CH3:11].[CH3:12][CH2:13][O:14][C:15](=[O:16])[C:17](/Cl)=[N:18]\[OH:19]>CCN(CC)CC.C1CCOC1>[CH3:12][CH2:13][O:14][C:15](=[O:16])[c:17]1[cH:1][c:2]([o:19][n:18]1)[CH2:3][NH:4][C:5](=[O:6])[O:7][C:8]([CH3:9])([CH3:10])[CH3:11]|US20190048013A1_0870
1.7.8|[O&H1&+0&D1:8]-[c:7]:[c&H0&+0&D3:6](:[c:5])-[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2](:[c:1])-Cl>>[o&H0&+0&D2:8]1:[c:7]:[c&H0&+0&D3:6](:[c:5]):[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1-[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1Cl)[Cl:14])[OH:15]>[O-]C([O-])=O.O=[Cu].c1ccncc1.[K+].[K+]>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[o:15][c:13]3[cH:12][c:11]([cH:10][cH:9][c:8]3[c:7]12)[Cl:14]|EP2881397B1_0185
1.3.6|[N&H2&+0&D1:8]-[c:7]:[n&H0&+0&D3:6](:[n:5])-[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2](:[c:1])-Br>>[n&H1&+0&D2:8]1:[c:7]:[n&H0&+0&D3:6](:[n:5]):[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2]:1:[c:1]|[NH2:1][C:2](=[O:3])[c:4]1[c:5]([n:6][n:7]([c:8]1[NH2:9])-[c:10]1[cH:11][cH:12][n:13][cH:14][c:15]1Br)-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[O:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>CNCCNC.CN(C)C=O.[O-]P([O-])([O-])=O.I[Cu].[K+].[K+].[K+]>[NH2:1][C:2](=[O:3])[c:4]1[c:5]([n:6][n:7]2[c:10]3[cH:11][cH:12][n:13][cH:14][c:15]3[nH:9][c:8]12)-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[O:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1|EP3130592A1_0611
4.2.4|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[C:4]-[C&H0&+0&D3:3](=[N&H0&+0&D2:2]-[O&H1&+0&D1:1])-Cl>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:6](-[C:5]):[o&H0&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:3]:1-[C:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](Cl)=[N:7][OH:8].[CH:9]#[C:10][CH2:11][Br:12]>CC(C)OC(C)C.CCN(CC)CC>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:9][c:10]([o:8][n:7]1)[CH2:11][Br:12]|EP3744722A1_0157
1.2.14|[C:8]-[N&H1&+0&D2:7]-[C:6].[C:5]-[C@@&H1&+0&D3:4]1-[O&H0&+0&D2:3]-[C@@&H1&+0&D3:2]-1-[c:1]>>[C:8]-[N&H0&+0&D3:7](-[C:6])-[C@@&H1&+0&D3:2](-[c:1])-[C@&H1&+0&D3:4](-[C:5])-[O&H1&+0&D1:3]|[CH3:1][C:2]1([O:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[C@@H:10]2[O:11][C@@H:12]21)[C:13]#[N:14])[CH3:15].[N:16]#[C:17][N:18]=[C:19]1[NH:20][CH2:21][CH2:22][S:23]1>CCN(CC)CC>[CH3:1][C:2]1([O:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]2[C@H:10]([C@@H:12]1[OH:11])[N:20]1[CH2:21][CH2:22][S:23][C:19]1=[N:18][C:17]#[N:16])[C:13]#[N:14])[CH3:15]|EP2368876A1_0064
4.3.9|[N&H0&+0&D1:7]#[C&H0&+0&D2:6]-[S&H0&+0&D2:5]-[#19].[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[N&H2&+0&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[s&H0&+0&D2:5]:1|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][C:9]([F:10])([F:11])[F:12].[N:13]#[C:14][S:15][K]>CC(=O)O.BrBr.N.O>[NH2:13][c:14]1[n:1][c:2]2[cH:3][cH:4][c:5]([cH:6][c:7]2[s:15]1)[O:8][C:9]([F:10])([F:11])[F:12]|EP3650449A1_0237
4.2.16|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[N&H1&+0&D2:4]-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:5]:[c&H0&+0&D3:2](-[C:1]):[c&H1&+0&D2:3]:[n&H0&+0&D2:4]:1|[CH3:1][CH2:2][C:3](=O)[CH2:4][NH:5][C:6](=[O:7])[CH2:8][S:9][c:10]1[cH:11][n:12][c:13]([s:14]1)[NH:15][C:16]([CH3:17])=[O:18]>[Na+].CC(=O)OC(C)=O.CC([O-])=O.O=S(=O)(O)O>[CH3:17][C:16](=[O:18])[NH:15][c:13]1[n:12][cH:11][c:10]([s:14]1)[S:9][CH2:8][c:6]1[n:5][cH:4][c:3]([o:7]1)[CH2:2][CH3:1]|US20200239435A1_0553
4.2.2|[C:7]-[C&H0&+0&D3:6](-[O&H0&+0&D2:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:3](-[C:2])-[N&H2&+0&D1:1])=O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:1]:[c&H0&+0&D3:3](-[C:2]):[n&H0&+0&D2:4]:[o&H0&+0&D2:5]:1|[CH3:1][S:2][CH2:3][C:4]([NH2:5])=[N:6][O:7][C:8](=O)[CH2:9][Cl:10]>>[CH3:1][S:2][CH2:3][c:4]1[n:5][c:8]([o:7][n:6]1)[CH2:9][Cl:10]|EP2857388A1_0073
4.2.3|[C:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1])=O>>[C:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:1]:[c&H0&+0&D3:3](-[C:2]):[n&H0&+0&D2:4]:[n&H0&+0&D2:5]:1|[O-:1][N+:2](=[O:3])[C:4]([CH2:5][CH2:6][C:7](=[O:8])[NH:9][NH:10][C:11](=O)[C:12]([F:13])([F:14])[C:15]([F:16])([F:17])[C:18]([F:19])([F:20])[F:21])([N+:22]([O-:23])=[O:24])[N+:25]([O-:26])=[O:27]>ClP(Cl)(Cl)(Cl)Cl.CC(Cl)Cl>[O-:1][N+:2](=[O:3])[C:4]([CH2:5][CH2:6][c:7]1[n:9][n:10][c:11]([o:8]1)[C:12]([F:14])([F:13])[C:15]([F:16])([F:17])[C:18]([F:19])([F:20])[F:21])([N+:22]([O-:23])=[O:24])[N+:25]([O-:26])=[O:27]|US07285568B2_0211
4.1.53|[C:7]-[C&H0&+0&D3:6](-[N&H2&+0&D1:5])=[N&H0&+0&D2:4]-[N&H1&+0&D2:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C:7]-[c&H0&+0&D3:6]1:[n&H1&+0&D2:5]:[c&H0&+0&D3:2](-[C:1]):[n&H0&+0&D2:3]:[n&H0&+0&D2:4]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([NH2:7])=[N:8][NH:9][C:10](=O)[CH2:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[F:18]>CO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:8][n:9][c:10]([nH:7]1)[CH2:11][c:12]1[cH:17][c:16]([cH:15][cH:14][cH:13]1)[F:18]|US20200062735A1_0584
4.3.8|[C:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1])=O>>[C:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](-[N:2]):[n&H0&+0&D2:4]:[n&H0&+0&D2:5]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[NH:7][NH:8][C:9](=[S:10])[N:11]1[CH2:12][CH2:13][N:14]([CH2:15][CH2:16]1)[C:17](=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[C:25]([F:26])([F:27])[F:28]>Cc1ccccc1.CN1CCCC1=O.CS(=O)(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][n:8][c:9]([s:10]1)[N:11]1[CH2:12][CH2:13][N:14]([CH2:15][CH2:16]1)[C:17](=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[C:25]([F:26])([F:27])[F:28]|US10472336B2_0529
4.1.60|[C:7]-[C&H0&+0&D3:6](=[C&H1&+0&D2:5]-O)-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c&H0&+0&D3:4]:1-[C:3]|O.[NH2:1][NH2:2].O=[C:3]1[CH2:4][CH:5]2[CH2:6][CH2:7][CH2:8][CH:9]([C:10]1=[CH:11]O)[N:12]2[S:13](=[O:14])(=[O:15])[c:16]1[cH:17][cH:18][c:19]([s:20]1)[Cl:21]>CC(=O)O>[O:14]=[S:13](=[O:15])([c:16]1[cH:17][cH:18][c:19]([s:20]1)[Cl:21])[N:12]1[CH:5]2[CH2:6][CH2:7][CH2:8][CH:9]1[c:10]1[cH:11][n:1][nH:2][c:3]1[CH2:4]2|US10342780B2_0885
4.3.9|[N&H0&+0&D1:7]#[C&H0&+0&D2:6]-[S&H0&+0&D2:5]-[#11].[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[N&H2&+0&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[s&H0&+0&D2:5]:1|[N:1]#[C:2][S:3][Na].[NH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[Cl:12]>CC(=O)O.BrBr>[NH2:1][c:2]1[n:4][c:5]2[c:10]([cH:9][c:8]([cH:7][c:6]2[s:3]1)[Cl:12])[Cl:11]|US20200361920A1_0414
4.3.9|[N&H0&+0&D1:7]#[C&H0&+0&D2:6]-[S&H0&+0&D2:5]-[#19].[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[n:1]>>[N&H2&+0&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[n:1]):[s&H0&+0&D2:5]:1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][n:8]1)[NH2:9].[N:10]#[C:11][S:12][K]>CC(=O)O.BrBr>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[n:9][c:11]([s:12][c:7]2[n:8]1)[NH2:10]|US20100137303A1_0196
4.1.101|[c:8]:[c&H0&+0&D3:7](:[c&H1&+0&D2:6]:[n:5])-[c&H0&+0&D3:4](:[n:3]):[c:2]-[N&H0&+&D3:1](-[O&-])=O>>[c:8]:[c&H0&+0&D3:7]1:[c&H0&+0&D3:6](:[n:5]):[n&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:4]:1:[n:3]|[CH3:1][c:2]1[cH:3][n:4][c:5]([c:6]([cH:7]1)[N+:8]([O-])=O)-[c:9]1[cH:10][cH:11][c:12]([n:13][cH:14]1)[F:15]>CCOP(OCC)OCC>[CH3:1][c:2]1[cH:3][n:4][c:5]2[c:9]3[cH:10][cH:11][c:12]([n:13][c:14]3[nH:8][c:6]2[cH:7]1)[F:15]|US20190040063A1_0554
4.1.2|[C:8]-[N&H2&+0&D1:7].[O&H0&D1:6]=[C&H0&+0&D3:5]1-[C:4]-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-1>>[C:8]-[N&H0&+0&D3:7]1-[C&H0&+0&D3:5](=[O&H0&D1:6])-[C:4]-[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([CH2:10][CH2:11]1)[c:12]1[n:13][cH:14][cH:15][cH:16][n:17]1.[O:18]=[C:19]1O[C:20]([CH:21]2[CH:22]3[CH2:23][CH2:24][CH:25]([CH2:26][CH2:27]3)[CH:28]12)=[O:29].CC(C)O.[ClH:30]>c1ccncc1>[O:29]=[C:20]1[CH:21]2[CH:22]3[CH2:23][CH2:24][CH:25]([CH2:26][CH2:27]3)[CH:28]2[C:19]([N:1]1[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([CH2:8][CH2:7]1)[c:12]1[n:13][cH:14][cH:15][cH:16][n:17]1)=[O:18].[ClH:30]|US20190194166A1_10394
4.1.101|[c:8]:[c&H0&+0&D3:7](:[c&H1&+0&D2:6]:[c:5])-[c&H0&+0&D3:4](:[n:3]):[c:2]-[N&H0&+&D3:1](-[O&-])=O>>[c:8]:[c&H0&+0&D3:7]1:[c&H0&+0&D3:6](:[c:5]):[n&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:4]:1:[n:3]|[CH3:1][C:2]1([c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2-[c:9]2[cH:10][cH:11][c:12]([cH:13][c:14]21)-[c:15]1[n:16][cH:17][cH:18][cH:19][c:20]1[N+:21]([O-])=O)-[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[CH3:28]>c1ccc(cc1)P(c1ccccc1)c1ccccc1>[CH3:1][C:2]1([c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2-[c:9]2[cH:10][c:11]3[nH:21][c:20]4[cH:19][cH:18][cH:17][n:16][c:15]4[c:12]3[cH:13][c:14]21)-[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[CH3:28]|EP3512848B1_0175
4.1.101|[c:8]:[c&H0&+0&D3:7](:[c:6]-[N&H0&+&D3:5](-[O&-])=O)-[c&H0&+0&D3:4](:[c:3]):[c&H1&+0&D2:2]:[n:1]>>[c:8]:[c&H0&+0&D3:7]1:[c:6]:[n&H1&+0&D2:5]:[c&H0&+0&D3:2](:[n:1]):[c&H0&+0&D3:4]:1:[c:3]|[O-][N+:1](=O)[c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1-[c:8]1[cH:9][n:10][cH:11][cH:12][cH:13]1)[O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH2:21][CH2:22][F:23]>CCOP(OCC)OCC>[F:23][CH2:22][CH2:21][O:20][CH2:19][CH2:18][O:17][CH2:16][CH2:15][O:14][c:4]1[cH:5][cH:6][c:7]2[c:8]3[cH:13][cH:12][cH:11][n:10][c:9]3[nH:1][c:2]2[cH:3]1|US20200010468A1_0731
8.8.18|[C:8]-[N&H0&+0&D3:7]1-[c:6]:[c:5]-[C&H2&+0&D2:4]-[C&H2&+0&D2:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]>>[C:8]-[n&H0&+0&D3:7]1:[c:6]:[c:5]:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[CH2:8][CH2:9][C:10]([N:11]2[CH2:12][CH2:13][CH2:14][Cl:15])=[O:16]>N#CC1=C(C(C(=C(C1=O)Cl)Cl)=O)C#N.CCOC(C)=O.C1COCCO1>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:7]1[cH:8][cH:9][c:10]([n:11]2[CH2:12][CH2:13][CH2:14][Cl:15])=[O:16]|US20200330462A1_0865
4.1.101|[c:8]:[c&H0&+0&D3:7](:[c:6]-[N&H0&+&D3:5](-[O&-])=O)-[c&H0&+0&D3:4](:[c:3]):[c&H1&+0&D2:2]:[c:1]>>[c:8]:[c&H0&+0&D3:7]1:[c:6]:[n&H1&+0&D2:5]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:4]:1:[c:3]|[O-][N+:1](=O)[c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[cH:9][cH:10][c:11]([c:12]2[C:13]([NH:14][C:15]([c:16]21)=[O:17])=[O:18])-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>c1ccc(cc1)P(c1ccccc1)c1ccccc1.Cc1cc(nc(c1)C)C>[O:18]=[C:13]1[NH:14][C:15]([c:16]2[c:12]1[c:11]([cH:10][c:9]1[nH:1][c:2]3[cH:3][cH:4][cH:5][cH:6][c:7]3[c:8]21)-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)=[O:17]|EP3016951B1_0481
4.1.12|[N&H4&+&D0:7].[C:6]-[C&H0&+0&D3:5](-[C&H2&+0&D2:4]-[N&H1&+0&D2:3]-[C&H0&+0&D3:2](-[C:1])=O)=O>>[n&H0&+0&D2:7]1:[c&H0&+0&D3:5](-[C:6]):[c&H1&+0&D2:4]:[n&H1&+0&D2:3]:[c&H0&+0&D3:2]:1-[C:1]|[NH4+:1].CC([O-])=O.[CH3:2][c:3]1[cH:4][n:5]([cH:6][n:7]1)-[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[O:14][CH3:15])/[CH:16]=[CH:17]/[C:18](=O)[NH:19][CH2:20][C:21](=O)[CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29]>O.[Na+].CCOC(C)=O.CC(=O)O.Cc1ccccc1C.[O-]C(=O)O>[CH3:2][c:3]1[cH:4][n:5]([cH:6][n:7]1)-[c:8]1[cH:9][cH:10][c:11]([cH:12][c:13]1[O:14][CH3:15])/[CH:16]=[CH:17]/[c:18]1[n:1][c:21]([cH:20][nH:19]1)[CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29]|US09868758B2_0143
4.1.2|[C:8]-[N&H2&+0&D1:7].[O&H0&D1:6]=[C&H0&+0&D3:5]1-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-1>>[C:8]-[N&H0&+0&D3:7]1-[C&H0&+0&D3:5](=[O&H0&D1:6])-[c:4]:[c:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[CH3:1][CH2:2][CH:3]([NH2:4])[CH2:5][OH:6].[O:7]=[C:8]1O[C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]12)=[O:16]>CC(C)O>[CH3:1][CH2:2][CH:3]([CH2:5][OH:6])[N:4]1[C:9]([c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[C:8]1=[O:7])=[O:16]|US20200291002A1_0199
7.6.1|[C:8]-[n&H0&+0&D3:7]1:[c&H1&+0&D2:6]:[c&H1&+0&D2:5]:[c:4]:[c:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1]>>[C:8]-[N&H0&+0&D3:7]1-[C&H2&+0&D2:6]-[C&H2&+0&D2:5]-[c:4]:[c:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|Cl.[CH3:1][n:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[c:9]2[c:10]([n:11]([cH:12][cH:13][c:14]21)[CH:15]1[CH2:16][N:17]2[CH2:18][CH2:19][CH:20]1[CH2:21][CH2:22]2)=[O:23]>CC(=O)O.[OH-].[OH-].[Pd+2]>[CH3:1][n:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[c:9]2[C:10]([N:11]([CH2:12][CH2:13][c:14]21)[CH:15]1[CH2:16][N:17]2[CH2:18][CH2:19][CH:20]1[CH2:21][CH2:22]2)=[O:23]|US09567339B2_1343
4.2.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[N&H0&+0&D2:1]-O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N:2]):[n&H0&+0&D2:1]:[o&H0&+0&D2:5]:1|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH:8][C:9](=[O:10])[c:11]1[cH:12][n:13][c:14]2[n:15]1[cH:16][cH:17][cH:18][cH:19]2)[NH:20][C:21]([NH2:22])=[N:23]O.[CH3:24][C:25]([CH3:26])([CH2:27][OH:28])[C:29](=[O:30])O>CN(C)C(On1nnc2c1nccc2)=[N+](C)C.CCN(C(C)C)C(C)C.F[P-](F)(F)(F)(F)F.CN(C)C=O.O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH:8][C:9](=[O:10])[c:11]1[cH:12][n:13][c:14]2[n:15]1[cH:16][cH:17][cH:18][cH:19]2)[NH:20][c:21]1[n:22][c:29]([o:30][n:23]1)[C:25]([CH3:24])([CH3:26])[CH2:27][OH:28]|US20130184257A1_0624
4.2.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[O:2])=[N&H0&+0&D2:1]-O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[O:2]):[n&H0&+0&D2:1]:[o&H0&+0&D2:5]:1|[O:1]=[C:2](O)[CH:3]1[CH2:4][CH:5]([CH2:6][N:7]([CH2:8]1)[C:9](=[O:10])[N:11]1[CH2:12][CH2:13][S:14][CH2:15][CH2:16]1)[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[O:23][C:24]([F:25])([F:26])[F:27].[CH3:28][CH:29]([CH3:30])[O:31][C:32]([NH2:33])=[N:34]O>CN(C)C(On1nnc2c1nccc2)=[N+](C)C.CC(C)N(CC)C(C)C.F[P-](F)(F)(F)(F)F.CN(C)C=O>[CH3:28][CH:29]([CH3:30])[O:31][c:32]1[n:33][c:2]([o:1][n:34]1)[CH:3]1[CH2:4][CH:5]([CH2:6][N:7]([CH2:8]1)[C:9](=[O:10])[N:11]1[CH2:12][CH2:13][S:14][CH2:15][CH2:16]1)[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[O:23][C:24]([F:25])([F:26])[F:27]|US08084469B2_1250
4.2.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N:2])-[N&H1&+0&D2:1]-O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N:2]):[n&H0&+0&D2:1]:[o&H0&+0&D2:5]:1|[NH:1]=[C:2]([NH:3]O)[NH:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=[O:12])[OH:13].[O:14]=[C:15](O)[C:16]([F:17])([F:18])[F:19]>C1CCOC1>[O:12]=[C:11]([OH:13])[c:8]1[cH:7][cH:6][c:5]([cH:10][cH:9]1)[NH:4][c:2]1[n:1][c:15]([o:14][n:3]1)[C:16]([F:17])([F:18])[F:19]|US20130184257A1_0536
4.1.8|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[C:3])=O)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](-[C:3]):[c&H1&+0&D2:5]:1|O.[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7][C:8](=O)[CH:9]=[CH:10][c:11]1[cH:12][cH:13][c:14]([c:15]([cH:16]1)[O:17][CH3:18])[OH:19].[NH2:20][NH2:21]>>[CH3:18][O:17][c:15]1[cH:16][c:11]([cH:12][cH:13][c:14]1[OH:19])[CH:10]=[CH:9][c:8]1[cH:7][c:6]([nH:21][n:20]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20080242661A1_0402
4.2.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O.[C:4]-[C&H0&+0&D3:3](=[N&H1&+0&D1:2])-[N&H1&+0&D2:1]-O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:1]:[o&H0&+0&D2:5]:1|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13](=[NH:14])[NH:15]O.[CH3:16][O:17][c:18]1[cH:19][c:20]([cH:21][c:22]([c:23]1[NH:24][C:25](=[O:26])[CH:27]([C:28](=[O:29])O)[c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)[O:36][CH3:37])[O:38][CH3:39]>O=C(c1ncc[nH]1)c1ncc[nH]1.C1CCOC1>[CH3:39][O:38][c:20]1[cH:19][c:18]([c:23]([c:22]([cH:21]1)[O:36][CH3:37])[NH:24][C:25](=[O:26])[CH:27]([c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)[c:28]1[n:14][c:13]([n:15][o:29]1)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH3:1])[O:17][CH3:16]|US07482448B2_0377
4.1.16|[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H2&+0&D1:4].[C:3](-[N&H1&+0&D2:2]-C(=O)-O-C(-C)(-C)-C)-[C&H0&+0&D3:1](=O)-O>>[n&H0&+0&D2:7]1:[c:6]:[c:5]:[n&H1&+0&D2:4]:[c&H0&+0&D3:1]:1-[C:3]-[N&H2&+0&D1:2]|CC(C)(C)OC(=O)[NH:1][C:2]1([CH2:3][CH2:4][CH2:5][CH2:6]1)[C:7](=O)O.[CH3:8][O:9][C:10](=[O:11])/[CH:12]=[CH:13]/[c:14]1[cH:15][cH:16][c:17]([c:18]([cH:19]1)[NH2:20])[NH2:21]>C1COCCO1.CC(=O)O.Cl>[CH3:8][O:9][C:10](=[O:11])/[CH:12]=[CH:13]/[c:14]1[cH:15][cH:16][c:17]2[nH:21][c:7]([n:20][c:18]2[cH:19]1)[C:2]1([CH2:3][CH2:4][CH2:5][CH2:6]1)[NH2:1]|US20110052562A1_0466
4.1.69|[C&H3&D1:7]-[C&H0&+0&D4:6](-O-C)(-O-C)-O-C.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[c:1]|[NH2:1][NH:2][c:3]1[n:4][cH:5][cH:6][c:7]2[n:8][c:9]([c:10]([cH:11][c:12]21)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[CH2:25][N:26]1[CH2:27][CH2:28][CH:29]([CH2:30][CH2:31]1)[c:32]1[n:33][nH:34][c:35]([n:36]1)-[c:37]1[cH:38][cH:39][cH:40][cH:41][n:42]1.CO[C:43]([CH3:44])(OC)OC>CN(C)C=O>[CH3:44][c:43]1[n:1][n:2][c:3]2[c:12]3[cH:11][c:10]([c:9]([n:8][c:7]3[cH:6][cH:5][n:4]12)-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[CH2:25][N:26]1[CH2:31][CH2:30][CH:29]([CH2:28][CH2:27]1)[c:32]1[n:33][nH:34][c:35]([n:36]1)-[c:37]1[cH:38][cH:39][cH:40][cH:41][n:42]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US04532242A
1.2.17|[C:9]-[C&H0&+0&D2:8]#[C&H0&+0&D2:7]-[c:6]:[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[c:6]:[c:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([C:4]#[N:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[NH:12][c:13]1[n:14][c:15]([n:16][cH:17][c:18]1[C:19]#[C:20][CH2:21][OH:22])[Cl:23]>CCCC[N+](CCCC)(CCCC)CCCC.C1CCOC1.[F-]>[CH3:1][C:2]([CH3:3])([C:4]#[N:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)-[n:12]1[c:20]([cH:19][c:18]2[cH:17][n:16][c:15]([n:14][c:13]21)[Cl:23])[CH2:21][OH:22]|US20200361939A1_1955
4.2.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O.[C:4]/[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[N&H0&+0&D2:1]\O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:1]:[o&H0&+0&D2:5]:1|[NH2:1]/[C:2](=[N:3]/O)[CH:4]1[CH2:5][CH2:6]1.[O:7]=[C:8](O)[CH2:9][N:10]1[C:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[C:18]1=[O:19])=[O:20]>O.CN(C)C=O.O=C(n1cncc1)n1cncc1>[O:19]=[C:18]1[c:17]2[cH:16][cH:15][cH:14][cH:13][c:12]2[C:11]([N:10]1[CH2:9][c:8]1[n:1][c:2]([n:3][o:7]1)[CH:4]1[CH2:5][CH2:6]1)=[O:20]|US08461134B2_0698
4.2.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[N&H0&+0&D2:1]-O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:1]:[o&H0&+0&D2:5]:1|[CH3:1][CH:2]([C:3](=[O:4])O)[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[F:11])-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[NH2:18][C:19]([CH2:20][CH2:21][O:22][CH:23]1[CH2:24][CH2:25][CH2:26][CH2:27][O:28]1)=[N:29]O>>[CH3:1][CH:2]([c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[F:11])-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:3]1[n:18][c:19]([n:29][o:4]1)[CH2:20][CH2:21][O:22][CH:23]1[CH2:24][CH2:25][CH2:26][CH2:27][O:28]1|EP3303284B1_0450
4.2.3|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[N&H1&+0&D2:4]-[N&H2&+0&D1:3].[C:2]-[C&H0&+0&D3:1](-O)=O>>[C:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:5]:[c&H0&+0&D3:1](-[C:2]):[n&H0&+0&D2:3]:[n&H0&+0&D2:4]:1|[CH3:1][n:2]1[c:3]([n:4][n:5][c:6]1[C:7]12[CH2:8][CH2:9][C:10]([CH2:11][CH2:12]1)([CH2:13][CH2:14]2)[C:15](=[O:16])[NH:17][NH2:18])-[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[C:25]([F:26])([F:27])[F:28].[CH3:29][C:30]([F:31])([F:32])[C:33](=O)O>ClCCl>[CH3:1][n:2]1[c:3]([n:4][n:5][c:6]1[C:7]12[CH2:14][CH2:13][C:10]([CH2:9][CH2:8]1)([CH2:11][CH2:12]2)[c:15]1[n:17][n:18][c:33]([o:16]1)[C:30]([CH3:29])([F:31])[F:32])-[c:19]1[cH:20][cH:21][cH:22][cH:23][c:24]1[C:25]([F:26])([F:27])[F:28]|US10864196B2_0385
4.1.2|[N&H2&+0&D1:8]-[N:7].[O&H0&D1:6]=[C&H0&+0&D3:5]1-[C:4]-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-1>>[N&H0&+0&D3:8]1(-[N:7])-[C&H0&+0&D3:5](=[O&H0&D1:6])-[C:4]-[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH:19]1[CH2:20][C:21](O[C:22]1=[O:23])=[O:24].[CH3:25][C:26]([CH3:27])([CH3:28])[c:29]1[cH:30][c:31]([cH:32][c:33]([c:34]1[OH:35])[C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:40][CH2:41][C:42](=[O:43])[NH:44][NH2:45]>Cc1ccccc1C.O>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH:19]1[CH2:20][C:21]([N:45]([C:22]1=[O:23])[NH:44][C:42](=[O:43])[CH2:41][CH2:40][c:31]1[cH:30][c:29]([c:34]([c:33]([cH:32]1)[C:36]([CH3:37])([CH3:38])[CH3:39])[OH:35])[C:26]([CH3:25])([CH3:27])[CH3:28])=[O:24]|EP0443540A1_0066
4.1.2|[N&H2&+0&D1:8]-[N:7].[O&H0&D1:6]=[C&H0&+0&D3:5]1-[C:4]=[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-1>>[N&H0&+0&D3:8]1(-[N:7])-[C&H0&+0&D3:5](=[O&H0&D1:6])-[C:4]=[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:16][CH2:17][C:18](=[O:19])[NH:20][NH2:21].[O:22]=[C:23]1[CH:24]=[CH:25][C:26](O1)=[O:27]>Cc1ccccc1C.O>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:16][CH2:17][C:18](=[O:19])[NH:20][N:21]1[C:26]([CH:25]=[CH:24][C:23]1=[O:22])=[O:27]|EP1257172B1_0051
4.3.3|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Cl)=O.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[S&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[s&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|[CH3:1][N:2]([CH2:3][C:4]([NH2:5])=[S:6])[C:7](=[O:8])[O:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.O=[C:16]([CH2:17][Cl:18])[CH2:19]Cl>CCO.c1ccncc1>[CH3:1][N:2]([CH2:3][c:4]1[n:5][c:16]([cH:19][s:6]1)[CH2:17][Cl:18])[C:7](=[O:8])[O:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US20130261154A1_0496
4.3.3|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Br)=O.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[S&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[s&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[N:6]([CH3:7])[CH2:8][C:9]([NH2:10])=[S:11].[CH3:12][CH2:13][O:14][C:15](=[O:16])[C:17](=O)[CH2:18]Br>CCO>[CH3:12][CH2:13][O:14][C:15](=[O:16])[c:17]1[cH:18][s:11][c:9]([n:10]1)[CH2:8][N:6]([CH3:7])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|EP3628672A1_0536
4.1.2|[N&H2&+0&D1:8]-[c:7].[O&H0&D1:6]=[C&H0&+0&D3:5]1-[C:4]-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-1>>[N&H0&+0&D3:8]1(-[c:7])-[C&H0&+0&D3:5](=[O&H0&D1:6])-[C:4]-[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[N+:8]([O-:9])=[O:10].[O:11]=[C:12]1O[C:13]([CH:14]2[CH:15]3[CH:16]=[CH:17][CH:18]([CH:19]4[CH2:20][CH:21]43)[CH:22]12)=[O:23]>O.CC(=O)O>[O-:9][N+:8](=[O:10])[c:5]1[cH:4][cH:3][c:2]([cH:7][cH:6]1)[N:1]1[C:12]([CH:22]2[CH:18]3[CH:17]=[CH:16][CH:15]([CH:21]4[CH2:20][CH:19]43)[CH:14]2[C:13]1=[O:23])=[O:11]|EP1575951B1_0560
4.2.16|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Cl)=O.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[O&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[o&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|[CH3:1][CH2:2][CH2:3][C:4]([NH2:5])=[O:6].O=[C:7]([CH2:8][Cl:9])[CH2:10]Cl>O.O=C(O)O[Na]>[CH3:1][CH2:2][CH2:3][c:4]1[n:5][c:7]([cH:10][o:6]1)[CH2:8][Cl:9]|EP1622896B1_0099
4.3.3|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Br)=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N:2]):[s&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=O)[CH2:6]Br.[NH2:7][C:8](=[S:9])[N:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[CH2:16][CH2:17][OH:18]>CCO.O[Na]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][s:9][c:8]([n:7]1)[N:10]1[CH2:15][CH2:14][N:13]([CH2:12][CH2:11]1)[CH2:16][CH2:17][OH:18]|US20200385375A1_0269
4.3.3|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Cl)=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N:2]):[s&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7]1)[C:8]([NH2:9])=[S:10].[CH3:11][C:12]([CH3:13])([CH3:14])[C:15](=O)[CH2:16]Cl>CCOCC.CCO>[CH3:11][C:12]([CH3:13])([CH3:14])[c:15]1[cH:16][s:10][c:8]([n:9]1)[N:5]1[CH2:4][CH2:3][N:2]([CH2:7][CH2:6]1)[CH3:1]|US04312869A
4.2.2|[C:7]-[C&H0&+0&D3:6](-[N&H2&+0&D1:5])=[N&H0&+0&D2:4]-O.[C:3]-[C&H0&+0&D3:2](=[O&H0&+0&D1:1])-Cl>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[c&H0&+0&D3:2](-[C:3]):[o&H0&+0&D2:1]:[n&H0&+0&D2:4]:1|[NH2:1][C:2]([CH2:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)=[N:10]O.[CH3:11][CH:12]([Cl:13])[C:14](=[O:15])Cl>CCN(CC)CC.CC(C)=O>[CH3:11][CH:12]([Cl:13])[c:14]1[n:1][c:2]([n:10][o:15]1)[CH2:3][c:4]1[cH:9][cH:8][cH:7][cH:6][cH:5]1|US10301284B2_0454
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H0&+&D3:5](-[O&-])=O.[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H1&+0&D2:8]1:[c&H0&+0&D3:1](:[n&H0&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[N+:8]([O-])=O)[NH2:9])[N:10]1[CH2:11][CH2:12][CH:13]([CH2:14][CH2:15]1)[NH:16][C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23].[CH3:24][O:25][c:26]1[n:27][cH:28][cH:29][c:30]([c:31]1[CH:32]=O)[I:33]>CO.[H][H].[Pd]>[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]2[nH:9][c:32]([n:8][c:7]12)-[c:31]1[c:30]([cH:29][cH:28][n:27][c:26]1[O:25][CH3:24])[I:33])[N:10]1[CH2:11][CH2:12][CH:13]([CH2:14][CH2:15]1)[NH:16][C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23]|EP1963315B1_0074
4.2.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-Cl.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N:2])-[N&H1&+0&D2:1]-O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N:2]):[n&H0&+0&D2:1]:[o&H0&+0&D2:5]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[C:14](=[NH:15])[NH:16]O.[CH3:17][C:18](=[O:19])[O:20][CH2:21][C:22](=[O:23])Cl>CC(C)N(CC)C(C)C.C1CCOC1.O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[c:14]1[n:15][c:22]([o:23][n:16]1)[CH2:21][O:20][C:18]([CH3:17])=[O:19]|EP2665719B1_0344
2.1.2|[C&H3&D1:8]-[N&H1&+0&D2:7]-[C&H1&+0&D3:6](-[C:5])-[C:4].[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C&H3&D1:8]-[N&H0&+0&D3:7](-[C&H0&+0&D3:2](-[C:3])=[O&H0&D1:1])-[C@@&H1&+0&D3:6](-[C:5])-[C:4]|[CH3:1][NH:2][C:3](=[O:4])[C@@H:5]([CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[N:13]([CH3:14])[C:15](=[O:16])[CH:17]([CH2:18][c:19]1[cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[cH:28]1)[NH:29][CH3:30].[CH3:31][C:32]([CH3:33])([CH2:34]/[CH:35]=[CH:36]/[C:37](=[O:38])O)[NH:39][C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46]>CCN=C=NCCCN(C)C.On1nnc2c1nccc2.CCN(C(C)C)C(C)C.CN(C)C=O.ClCCl.Cl>[CH3:1][NH:2][C:3](=[O:4])[C@@H:5]([CH2:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[N:13]([CH3:14])[C:15](=[O:16])[C@@H:17]([CH2:18][c:19]1[cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[cH:28]1)[N:29]([CH3:30])[C:37](=[O:38])/[CH:36]=[CH:35]/[CH2:34][C:32]([CH3:31])([CH3:33])[NH:39][C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46]|US20030040483A1_0335
4.1.2|[N&H2&+0&D1:8]-[c:7].[O&H0&D1:6]=[C&H0&+0&D3:5]1-[C:4]=[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-1>>[N&H0&+0&D3:8]1(-[c:7])-[C&H0&+0&D3:5](=[O&H0&D1:6])-[C:4]=[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[F:8])[Cl:9].[O:10]=[C:11]1O[C:12]([C:13]2[CH2:14][CH2:15][CH2:16][CH2:17][C:18]=21)=[O:19]>CC(=O)O>[O:10]=[C:11]1[C:18]2[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=2[C:12]([N:1]1[c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[F:8])[Cl:9])=[O:19]|US20200024266A1_1297
4.3.3|[C:7]-[C&H1&+0&D3:6](-[C&H1&+0&D2:5]=O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H1&+0&D2:5]:1)-[N:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[C:8]([CH3:9])([CH3:10])[O:11][N:12]=[C:13]([C:14](=[O:15])[NH:16][CH:17]1[C:18]([N:19]2[CH:20]1[S:21][CH2:22][C:23](=[C:24]2[C:25](=[O:26])[O:27][CH:28]([c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)[c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1)[CH:41](Br)[CH:42]=O)=[O:43])[c:44]1[cH:45][s:46][c:47]([n:48]1)[NH:49][C:50]([c:51]1[cH:52][cH:53][cH:54][cH:55][cH:56]1)([c:57]1[cH:58][cH:59][cH:60][cH:61][cH:62]1)[c:63]1[cH:64][cH:65][cH:66][cH:67][cH:68]1.[NH2:69][C:70](=[S:71])[NH:72][c:73]1[cH:74][cH:75][cH:76][n:77][cH:78]1>CC(=O)OCC.c1ccncc1.C1CCOC1.O.Cl>[CH3:3][C:2]([CH3:4])([CH3:1])[O:5][C:6](=[O:7])[C:8]([CH3:9])([CH3:10])[O:11][N:12]=[C:13]([C:14](=[O:15])[NH:16][CH:17]1[C:18]([N:19]2[CH:20]1[S:21][CH2:22][C:23](=[C:24]2[C:25](=[O:26])[O:27][CH:28]([c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)[c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1)[c:41]1[cH:42][n:69][c:70]([s:71]1)[NH:72][c:73]1[cH:74][cH:75][cH:76][n:77][cH:78]1)=[O:43])[c:44]1[cH:45][s:46][c:47]([n:48]1)[NH:49][C:50]([c:51]1[cH:52][cH:53][cH:54][cH:55][cH:56]1)([c:57]1[cH:58][cH:59][cH:60][cH:61][cH:62]1)[c:63]1[cH:64][cH:65][cH:66][cH:67][cH:68]1|US20110301155A1_1206
4.1.2|[N&H2&+0&D1:8]-[N:7].[O&H0&D1:6]=[C&H0&+0&D3:5]1-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-1>>[N&H0&+0&D3:8]1(-[N:7])-[C&H0&+0&D3:5](=[O&H0&D1:6])-[c:4]:[c:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[NH2:1][NH:2][c:3]1[cH:4][cH:5][n:6][cH:7][c:8]1[F:9].[O:10]=[C:11]1O[C:12]([c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]12)=[O:19]>CC(=O)O>[O:19]=[C:12]1[c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[C:11]([N:1]1[NH:2][c:3]1[cH:4][cH:5][n:6][cH:7][c:8]1[F:9])=[O:10]|US20200331881A1_0553
4.2.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-Cl.[C:4]-[C&H0&+0&D3:3](=[N&H1&+0&D1:2])-[N&H1&+0&D2:1]-O>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:1]:[o&H0&+0&D2:5]:1|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][C:10](=[NH:11])[NH:12]O.[CH3:13][O:14][C:15](=[O:16])[CH2:17][CH2:18][C:19](=[O:20])Cl>CCOC(C)=O.CC#N.c1ccncc1>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][c:10]1[n:11][c:19]([o:20][n:12]1)[CH2:18][CH2:17][C:15](=[O:16])[O:14][CH3:13]|US20090042929A1_0351
4.3.3|[C:7]-[C&H0&+0&D3:6](-[N&H2&+0&D1:5])=[S&H0&+0&D1:4].[C:3]-[C&H1&+0&D3:2](-[C&H1&+0&D2:1]=O)-Cl>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](-[C:3]):[s&H0&+0&D2:4]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Cl)[CH:7]=O.[CH3:8][CH2:9][CH2:10][C:11]([NH2:12])=[S:13]>C1COCCO1.[O-]C([O-])=O.[Mg+2]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:12][c:11]([s:13]1)[CH2:10][CH2:9][CH3:8]|US09187472B2_5745
8.8.18|[Br&H0&D1:8]-[C&H0&+0&D3:7]1-[C&H2&+0&D2:6]-[C&H2&+0&D2:5]-[c:4]:[c:3]-[C&H0&+0&D3:2]=1-[C:1]>>[Br&H0&D1:8]-[c&H0&+0&D3:7]1:[c&H1&+0&D2:6]:[c&H1&+0&D2:5]:[c:4]:[c:3]:[c&H0&+0&D3:2]:1-[C:1]|[O:1]=[CH:2][C:3]1=[C:4]([CH2:5][CH2:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]12)[Br:13]>Cc1ccccc1.N#CC1=C(C(C(=C(C1=O)Cl)Cl)=O)C#N>[O:1]=[CH:2][c:3]1[c:4]([cH:5][cH:6][c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]21)[Br:13]|EP1914229A1_0795
4.1.2|[N&H2&+0&D1:8]-[c:7].[O&H0&D1:6]=[C&H0&+0&D3:5]1-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-1>>[N&H0&+0&D3:8]1(-[c:7])-[C&H0&+0&D3:5](=[O&H0&D1:6])-[c:4]:[c:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[Cl:8])[N+:9]([O-:10])=[O:11].[O:12]=[C:13]1O[C:14]([c:15]2[cH:16][cH:17][c:18]([cH:19][c:20]12)[Cl:21])=[O:22]>CC(=O)O>[O-:10][N+:9](=[O:11])[c:5]1[cH:4][cH:3][c:2]([c:7]([cH:6]1)[Cl:8])[N:1]1[C:14]([c:15]2[cH:16][cH:17][c:18]([cH:19][c:20]2[C:13]1=[O:12])[Cl:21])=[O:22]|EP2099748B1_0220
4.2.16|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Br)=O.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[O&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[o&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|[NH2:1][C:2](=[O:3])[CH:4]=[CH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[C:12]([F:13])([F:14])[F:15].[CH3:16][CH2:17][O:18][C:19](=[O:20])[C:21](=O)[CH2:22]Br>O=C(OC(=O)C(F)(F)F)C(F)(F)F.C1CCOC1.[O-]C(=O)O.[Na+]>[CH3:16][CH2:17][O:18][C:19](=[O:20])[c:21]1[cH:22][o:3][c:2]([n:1]1)[CH:4]=[CH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[C:12]([F:13])([F:14])[F:15]|US20200407339A1_1114
4.1.40|[C:8]-[C&H0&+0&D2:7]#[N&H0&+0&D1:6].[N&H2&+0&D1:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:8]-[c&H0&+0&D3:7]1:[n&H1&+0&D2:6]:[c&H0&+0&D3:2](=[O&H0&D1:1]):[c:3]:[c:4]:[n&H0&+0&D2:5]:1|[CH3:1][c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[Cl:8])[NH2:9])[C:10](=[O:11])O.[N:12]#[C:13][CH2:14][Cl:15]>CO.[Na]>[CH3:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][c:7]1[Cl:8])[n:9][c:13]([nH:12][c:10]2=[O:11])[CH2:14][Cl:15]|US20130317045A1_0614
2.2.3|[N&H2&+0&D1:8]-[c:7]:[c:6]-[O&H0&+0&D2:5]-C.[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[N&H1&+0&D2:8](-[c:7]:[c:6]-[O&H1&+0&D1:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[O:1]=[S:2](=[O:3])(Cl)[c:4]1[cH:5][cH:6][c:7]([n:8][cH:9]1)[C:10]([F:11])([F:12])[F:13].C[O:14][c:15]1[cH:16][c:17]([cH:18][n:19][c:20]1[NH2:21])[Br:22]>COc1cc(cnc1NS(=O)(=O)c1sc(nc1C)C)Cl.Cc1nc(c(s1)S(=O)(=O)Cl)C.COc1cc(cnc1N)Cl>[O:1]=[S:2](=[O:3])([NH:21][c:20]1[n:19][cH:18][c:17]([cH:16][c:15]1[OH:14])[Br:22])[c:4]1[cH:5][cH:6][c:7]([n:8][cH:9]1)[C:10]([F:11])([F:12])[F:13]|US09873687B2_0873
4.1.45|[C:9]-[C&H1&+0&D2:8]=O.[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:9][c:10]1[cH:11][cH:12][n:13][cH:14][c:15]1[NH2:16].O=[CH:17][C:18]([F:19])([F:20])[F:21].O>[O-]S(=O)S([O-])(=O)=O.CC(=O)OCC.CC(=O)N(C)C.[Na+].[Na+]>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[n:9]1[c:10]2[cH:11][cH:12][n:13][cH:14][c:15]2[n:16][c:17]1[C:18]([F:19])([F:20])[F:21]|US20190233384A1_0237
2.4.4|[C:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[O&H1&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[C:7]-[n&H0&+0&D3:6]1:[c:5]:[c:4]:[o&H0&+0&D2:3]:[c&H0&+0&D3:1]:1=[O&H0&D1:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[NH:14][c:15]1[cH:16][cH:17][cH:18][cH:19][c:20]1[OH:21].[O:22]=[C:23](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>CC(C)N(CC)C(C)C.C1CCOC1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[n:14]1[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]2[o:21][c:23]1=[O:22]|US09505749B2_0504
4.1.29|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C:5])=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[C&H1&+0&D2:1]=O>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[c&H1&+0&D2:1]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]([CH3:8])=O.[NH2:9][c:10]1[cH:11][c:12]([cH:13][cH:14][c:15]1[CH:16]=O)[NH:17][C:18](=[O:19])[c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1-[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[C:32]([F:33])([F:34])[F:35]>O.[Na+].CC(=O)O.[OH-]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:16][c:15]2[cH:14][cH:13][c:12]([cH:11][c:10]2[n:9][c:7]1[CH3:8])[NH:17][C:18](=[O:19])[c:20]1[cH:21][cH:22][cH:23][cH:24][c:25]1-[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[C:32]([F:33])([F:34])[F:35]|EP2401275B1_0441
2.2.3|[N&H2&+0&D1:8]-[C:7]-[C:6]-[O&H0&+0&D2:5]-C.[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[N&H1&+0&D2:8](-[C:7]-[C:6]-[O&H1&+0&D1:5])-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|C[O:1][C:2](=[O:3])[C@@H:4]([NH2:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[Cl:13])[CH:14]1[CH2:15][C:16]([NH:17][S:18]1(=[O:19])=[O:20])=[O:21].[O:22]=[S:23](=[O:24])(Cl)[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1.O=C(O)C(F)(F)F>CCN(CC)CC.O=C(O)C(F)(F)F.CO.O[Li].Cl>[O:3]=[C:2]([OH:1])[C@H:4]([CH2:6][c:7]1[cH:8][cH:9][c:10]([c:11]([cH:12]1)[Cl:13])[CH:14]1[CH2:15][C:16]([NH:17][S:18]1(=[O:19])=[O:20])=[O:21])[NH:5][S:23](=[O:22])(=[O:24])[c:25]1[cH:30][cH:29][cH:28][cH:27][cH:26]1|US10626112B2_0448
1.2.17|[C:9]-[N&H1&+0&D2:8]-[c:7]:[c:6]-[C&H0&+0&D2:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[n&H0&+0&D3:8]1:[c&H0&+0&D3:4](:[c&H1&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]#[C:10][c:11]1[cH:12][cH:13][cH:14][c:15]2[C:16]([NH:17][CH2:18][CH2:19][NH:20][c:21]12)=[O:22]>CC#N.Cl[Pd]Cl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][c:11]2[cH:12][cH:13][cH:14][c:15]3[C:16]([NH:17][CH2:18][CH2:19][n:20]1[c:21]23)=[O:22]|US20110218189A1_0292
2.3.8|[C:7]-[N&H1&+0&D2:6]-[C:5]-[C:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[C:7]-[N&H0&+0&D3:6]1-[C:5]-[C:4]-[N&H1&+0&D2:3]-[C&H0&+0&D3:1]-1=[O&H0&D1:2]|[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)-[c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[CH2:16][NH:17][CH2:18][CH:19]([NH2:20])[c:21]1[cH:22][c:23]([cH:24][c:25]([cH:26]1)[C:27]([F:28])([F:29])[F:30])[C:31]([F:32])([F:33])[F:34])[C:35]([F:36])([F:37])[F:38])[O:39][CH3:40].[O:41]=[C:42](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>CC(C)N(CC)C(C)C.[O-]C(=O)O.ClCCl.[Na+]>[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)-[c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[CH2:16][N:17]1[CH2:18][CH:19]([NH:20][C:42]1=[O:41])[c:21]1[cH:22][c:23]([cH:24][c:25]([cH:26]1)[C:27]([F:28])([F:29])[F:30])[C:31]([F:32])([F:33])[F:34])[C:35]([F:36])([F:37])[F:38])[O:39][CH3:40]|US20190152992A1_0079
4.1.4|[C:8]-[C&H0&+0&D2:7]#[C&H0&+0&D2:6]-[C:5].[C:4]-[N&H0&+0&D2:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[c&H0&+0&D3:6](-[C:5]):[n&H0&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D3:3]:1-[C:4]|[N-:1]=[N+:2]=[N:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[Cl:11].[CH3:12][O:13][C:14](=[O:15])[C:16]#[C:17][C:18](=[O:19])[O:20][CH3:21]>c1ccccc1.C1CCCCC1>[CH3:21][O:20][C:18](=[O:19])[c:17]1[c:16]([n:1][n:2][n:3]1[CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[Cl:11])[C:14](=[O:15])[O:13][CH3:12]|US20140023611A1_1699
2.1.10|[C:8]-[N&H1&+0&D2:7]-[c:6]:[c:5]/[C&H1&+0&D2:4]=[C&H1&+0&D2:3]/[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[C:8]-[n&H0&+0&D3:7]1:[c:6]:[c:5]:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1]|CO[C:1](=[O:2])/[CH:3]=[CH:4]/[c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[NH:11][CH2:12][CH2:13][CH2:14][O:15][c:16]1[cH:17][cH:18][c:19]2[c:20]([n:21][o:22][c:23]2[c:24]1[CH2:25][CH2:26][CH3:27])[C:28]([F:29])([F:30])[F:31])[CH2:32][C:33](=[O:34])[O:35][CH3:36]>CO>[CH3:36][O:35][C:33](=[O:34])[CH2:32][c:7]1[cH:8][cH:9][c:10]2[c:5]([cH:6]1)[cH:4][cH:3][c:1]([n:11]2[CH2:12][CH2:13][CH2:14][O:15][c:16]1[cH:17][cH:18][c:19]2[c:20]([n:21][o:22][c:23]2[c:24]1[CH2:25][CH2:26][CH3:27])[C:28]([F:29])([F:30])[F:31])=[O:2]|US10487093B2_0798
4.1.101|[c:8]:[c&H0&+0&D3:7](:[c&H1&+0&D2:6]:[c:5])-[c&H0&+0&D3:4](:[n:3]):[c:2]-[N&H0&+0&D2:1]=[N&+]=[N&-]>>[c:8]:[c&H0&+0&D3:7]1:[c&H0&+0&D3:6](:[c:5]):[n&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:4]:1:[n:3]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[n:10][c:11]([cH:12][c:13]([c:14]1[N:15]=[N+]=[N-])[C:16](=[O:17])[O:18][CH3:19])-[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[O:26][CH3:27]>Clc1ccccc1Cl>[CH3:19][O:18][C:16](=[O:17])[c:13]1[cH:12][c:11]([n:10][c:9]2[c:6]3[cH:7][cH:8][c:3]([cH:4][c:5]3[nH:15][c:14]21)[O:2][CH3:1])-[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[O:26][CH3:27]|US08815840B2_0824
4.1.46|[C:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[C:7]-[n&H0&+0&D3:6]1:[c:5]:[c:4]:[n&H1&+0&D2:3]:[c&H0&+0&D3:1]:1=[O&H0&D1:2]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[O:16]=[C:17](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>ClCCl.O>[O:16]=[c:17]1[nH:1][c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[n:8]1[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US20160304510A1_0603
4.1.23|[N&H2&+0&D1:7]-[c:6]:[c&H1&+0&D2:5]:[n:4].[C&H2&+0&D2:3](-[C&H1&+0&D3:2](-[C&H2&+0&D2:1]-O)-O)-O>>[n&H0&+0&D2:7]1:[c&H1&+0&D2:3]:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:[c&H0&+0&D3:5](:[n:4]):[c:6]:1|[NH2:1][c:2]1[cH:3][cH:4][cH:5][n:6][cH:7]1.O[CH2:8][CH:9](O)[CH2:10]O>>[cH:5]1[cH:4][cH:3][c:2]2[n:1][cH:10][cH:9][cH:8][c:7]2[n:6]1|US20200147234A1_0156
4.1.23|[N&H2&+0&D1:7]-[c:6]:[c&H1&+0&D2:5]:[c:4].[C&H2&+0&D2:3](-[C&H1&+0&D3:2](-[C&H2&+0&D2:1]-O)-O)-O>>[n&H0&+0&D2:7]1:[c&H1&+0&D2:3]:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:[c&H0&+0&D3:5](:[c:4]):[c:6]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[NH2:11].O[CH2:12][CH:13](O)[CH2:14]O>[O-]S(=O)(=O)c1cccc(c1)[N+]([O-])=O.O=S(=O)(O)O.O[Na].O.[Na+]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:10][cH:9][c:8]2[n:11][cH:14][cH:13][cH:12][c:7]2[cH:6]1|US08993612B2_0455
7.6.1|[C:8]-[c&H0&+0&D3:7]1:[c&H1&+0&D2:6]:[c&H0&+0&D3:5](=[O&H0&D1:4]):[c:3]:[c:2]:[o&H0&+0&D2:1]:1>>[C:8]-[C&H1&+0&D3:7]1-[C&H2&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c:3]:[c:2]-[O&H0&+0&D2:1]-1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([c:9]2[cH:10][c:11]([cH:12][c:13]([c:14]2[o:15]1)[C:16]([CH3:17])([CH3:18])[CH3:19])[C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24]>[H][H].[Ni]>[CH3:21][C:20]([CH3:22])([CH3:23])[c:11]1[cH:12][c:13]([c:14]2[O:15][CH:6]([CH2:7][C:8]([c:9]2[cH:10]1)=[O:24])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[C:16]([CH3:17])([CH3:18])[CH3:19]|EP0331078A2_0084
2.2.3|[C:8]-[C&H1&+0&D3:7](-[C:6])-[N&H2&+0&D1:5].[O&H0&D1:4]=[S&H0&+0&D4:3](=[O&H0&D1:2])(-[c:1])-Cl>>[C:8]-[C@&H1&+0&D3:7](-[C:6])-[N&H1&+0&D2:5]-[S&H0&+0&D4:3](=[O&H0&D1:4])(=[O&H0&D1:2])-[c:1]|[NH2:1][CH:2]([CH2:3][C:4](=[O:5])[O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[C:14](=[O:15])[OH:16].[O:17]=[S:18](=[O:19])(Cl)[c:20]1[cH:21][cH:22][c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[cH:29]1>C1COCCO1.[Na+].Cl.[OH-]>[O:5]=[C:4]([CH2:3][C@@H:2]([NH:1][S:18](=[O:17])(=[O:19])[c:20]1[cH:21][cH:22][c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[cH:29]1)[C:14](=[O:15])[OH:16])[O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|EP0944386B1_0257
4.1.45|[c:8]:[c&H0&+0&D3:7](:[c:6])-[N&H1&+0&D2:5]-[c:4]:[c:3]-[N&H0&+&D3:2](-[O&-])=O.[C&H1&+0&D2:1](=O)-O>>[c:8]:[c&H0&+0&D3:7](:[c:6])-[n&H0&+0&D3:5]1:[c&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c:3]:[c:4]:1|[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]=[C:6]([CH2:7]1)[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[NH:14][c:15]1[cH:16][cH:17][c:18]([cH:19][c:20]1[N+:21]([O-])=O)[C:22]([CH3:23])=[O:24].O=[CH:25]O>S([Na])[Na]>[CH3:23][C:22](=[O:24])[c:18]1[cH:17][cH:16][c:15]2[c:20]([cH:19]1)[n:21][cH:25][n:14]2-[c:12]1[cH:13][c:8]([cH:9][cH:10][cH:11]1)[C:6]1=[CH:5][CH2:4][CH2:3][N:2]([CH2:7]1)[CH3:1]|US20190308938A1_0940
4.1.65|[N&H2&+0&D1:7]-[C&H2&+0&D2:6]-[C&H1&+0&D3:5](-O-C)-O-C.[c:4]:[c&H1&+0&D2:3]:[c:2]-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:7]1:[c&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:3](:[c:4]):[c&H1&+0&D2:5]:[c&H1&+0&D2:6]:1|CO[CH:1]([CH2:2][NH2:3])OC.[CH3:4][c:5]1[cH:6][cH:7][cH:8][c:9]([c:10]1[Cl:11])[CH:12]=O>>[CH3:4][c:5]1[cH:6][cH:7][c:8]2[cH:1][cH:2][n:3][cH:12][c:9]2[c:10]1[Cl:11]|US05362878A
2.3.8|[N&H2&+0&D1:7]-[C:6]-[C:5]-[N&H1&+0&D2:4]-[c:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[N&H1&+0&D2:7]1-[C:6]-[C:5]-[N&H0&+0&D3:4](-[c:3])-[C&H0&+0&D3:1]-1=[O&H0&D1:2]|[CH3:1][O:2][C:3](=[O:4])[C:5]([CH3:6])([NH2:7])[CH2:8][NH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[F:16].[O:17]=[C:18](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>CCN(CC)CC.C1CCOC1.ClCCl>[CH3:1][O:2][C:3](=[O:4])[C:5]1([CH2:8][N:9]([C:18]([NH:7]1)=[O:17])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[F:16])[CH3:6]|US20200360379A1_1349
4.1.60|[C:7]-[C&H0&+0&D3:6](=[C&H1&+0&D2:5]-N(-C)-C)-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c&H0&+0&D3:4]:1-[C:3]|O.CN(C)[CH:1]=[C:2]1[C:3]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]1=O)=[O:9].[NH2:10][NH2:11]>CO>[O:9]=[C:3]1[CH2:4][CH2:5][CH2:6][CH2:7][c:8]2[nH:11][n:10][cH:1][c:2]12|US08778984B2_0194
4.1.47|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H1&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[c:2].[N&H0&+0&D2:1](=O)-O-C-C-C-C>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:1]:[n&H0&+0&D3:5](:[c:6]:[c:7]:1)-[c&H0&+0&D3:4](:[c:3]):[c:2]|[CH3:1][CH2:2][CH:3]([CH2:4][CH3:5])[NH:6][c:7]1[cH:8][c:9]([n:10][c:11]([c:12]1[NH2:13])[NH:14][c:15]1[c:16]([cH:17][c:18]([cH:19][c:20]1[CH3:21])[CH3:22])[CH3:23])[CH3:24].CCCCO[N:25]=O>[Na+].Cl.CC#N.[OH-]>[CH3:22][c:18]1[cH:19][c:20]([c:15]([c:16]([cH:17]1)[CH3:23])-[n:14]1[n:25][n:13][c:12]2[c:7]([cH:8][c:9]([n:10][c:11]21)[CH3:24])[NH:6][CH:3]([CH2:4][CH3:5])[CH2:2][CH3:1])[CH3:21]|US09855268B2_0764
4.1.60|[C:7]-[C&H0&+0&D3:6](=[C&H1&+0&D2:5]-N(-C)-C)-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:4]:1-[C:3]|O.[CH3:1][C:2]1([CH2:3][CH2:4][C:5]([C:6]1=O)=[CH:7]N(C)C)[CH3:8].[NH2:9][NH2:10]>CCO>[CH3:1][C:2]1([CH2:3][CH2:4][c:5]2[cH:7][nH:9][n:10][c:6]21)[CH3:8]|US20170210751A1_1115
4.1.45|[C:9]-[N&H1&+0&D2:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[C:9]-[n&H0&+0&D3:8]1:[c&H0&+0&D3:1](:[n&H0&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][CH:2]([CH3:3])[CH2:4][NH:5][c:6]1[c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[n:13][cH:14][c:15]1[NH2:16].[CH3:17][O:18][c:19]1[cH:20][c:21]([cH:22][cH:23][c:24]1[O:25][CH3:26])[CH:27]=O>>[CH3:26][O:25][c:24]1[cH:23][cH:22][c:21]([cH:20][c:19]1[O:18][CH3:17])-[c:27]1[n:16][c:15]2[cH:14][n:13][c:12]3[cH:11][cH:10][cH:9][cH:8][c:7]3[c:6]2[n:5]1[CH2:4][CH:2]([CH3:1])[CH3:3]|EP3162802B1_0343
1.2.14|[C&H3&D1:7]-[N&H1&+0&D2:6]-[C&H3&D1:5].[C:4]-[C@@&H1&+0&D3:3]1-[C&H2&+0&D2:2]-[O&H0&+0&D2:1]-1>>[C&H3&D1:7]-[N&H0&+0&D3:6](-[C&H3&D1:5])-[C&H2&+0&D2:2]-[C@@&H1&+0&D3:3](-[C:4])-[O&H1&+0&D1:1]|[CH3:1][c:2]1[cH:3][nH:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]12)[O:11][c:12]1[n:13][cH:14][n:15][c:16]2[cH:17][c:18]([c:19]([cH:20][c:21]12)[O:22][CH3:23])[O:24][CH2:25][C@H:26]1[CH2:27][O:28]1.[CH3:29][NH:30][CH3:31]>CCO.CN(C)C=O>[CH3:29][N:30]([CH3:31])[CH2:27][C@@H:26]([OH:28])[CH2:25][O:24][c:18]1[cH:17][c:16]2[n:15][cH:14][n:13][c:12]([c:21]2[cH:20][c:19]1[O:22][CH3:23])[O:11][c:8]1[cH:7][cH:6][c:5]2[nH:4][cH:3][c:2]([c:10]2[cH:9]1)[CH3:1]|US20120010235A1_0512
4.1.45|[C:9]-[N&H1&+0&D2:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[n:2])-[C&H1&+0&D2:1]=O>>[C:9]-[n&H0&+0&D3:8]1:[c&H0&+0&D3:1](:[n&H0&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[n:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[NH2:12])[NH:13][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1.O=[CH:20][c:21]1[cH:22][cH:23][cH:24][cH:25][n:26]1>O.CN(C)C=O.O=S(=O)(OO)O[K]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:11][c:10]2[n:12][c:20]([n:13]([c:9]2[cH:8][cH:7]1)[CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1)-[c:21]1[cH:22][cH:23][cH:24][cH:25][n:26]1|US10259809B2_0348
4.2.4|[C&H1&+0&D1:7]#[C&H0&+0&D2:6]-[C:5].[C&H3&D1:4]-[C&H1&+0&D2:3]=[N&H0&+0&D2:2]-[O&H1&+0&D1:1]>>[c&H1&+0&D2:7]1:[c&H0&+0&D3:6](-[C:5]):[o&H0&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:3]:1-[C&H3&D1:4]|[CH:1]#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][c:13]1[c:14]([cH:15][c:16]([cH:17][c:18]1[CH3:19])-[c:20]1[n:21][o:22][c:23]([n:24]1)[C:25]([F:26])([F:27])[F:28])[CH3:29].[CH3:30][CH:31]=[N:32][OH:33]>>[CH3:30][c:31]1[cH:1][c:2]([o:33][n:32]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][c:13]1[c:14]([cH:15][c:16]([cH:17][c:18]1[CH3:19])-[c:20]1[n:21][o:22][c:23]([n:24]1)[C:25]([F:26])([F:27])[F:28])[CH3:29]|US09321727B2_0822
4.1.22|[N&H2&+0&D1:8]-[c:7].[O&H0&D1:6]=[C&H0&+0&D3:5](-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-Cl)-Cl>>[N&H0&+0&D3:8]1(-[c:7])-[C&H0&+0&D3:5](=[O&H0&D1:6])-[c:4]:[c:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[NH2:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[nH:10]1.[O:11]=[C:12](Cl)[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[C:19](=[O:20])Cl>c1ccncc1>[O:20]=[C:19]1[c:18]2[cH:17][cH:16][cH:15][cH:14][c:13]2[C:12]([N:1]1[c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[nH:10]1)=[O:11]|US20200172512A1_0700
4.2.4|[C:7]-[C&H0&+0&D3:6](=[C&H1&+0&D2:5]-N(-C)-C)-[C&H0&+0&D3:4](-[C:3])=O.[N&H2&+0&D1:2]-[O&H1&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[c&H1&+0&D2:5]:[n&H0&+0&D2:2]:[o&H0&+0&D2:1]:[c&H0&+0&D3:4]:1-[C:3]|Cl.CN(C)[CH:1]=[C:2]([C:3](=[O:4])[c:5]1[n:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[Cl:12])[C:13](=O)[CH:14]1[CH2:15][CH2:16]1.[NH2:17][OH:18]>CCO>[O:4]=[C:3]([c:5]1[n:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[Cl:12])[c:2]1[cH:1][n:17][o:18][c:13]1[CH:14]1[CH2:15][CH2:16]1|EP0918056A1_0055
4.1.40|[N&H2&+0&D1:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[c:4]:[c:3]-[N&H2&+0&D1:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H1&+0&D2:7]1:[c&H0&+0&D3:6](=[O&H0&D1:5]):[c:4]:[c:3]:[n&H0&+0&D2:2]:[c&H1&+0&D2:1]:1|CO[CH:1](OC)OC.[NH2:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[C:9]([NH2:10])=[O:11])[CH:12]([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[n:19]1[cH:20][cH:21][n:22][cH:23]1>O=CO>[O:11]=[c:9]1[nH:10][cH:1][n:2][c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]21)[CH:12]([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[n:19]1[cH:23][n:22][cH:21][cH:20]1|US20190284189A1_0607
4.1.62|[C:8]-[C&H0&+0&D3:7](-[N&H1&+0&D2:6]-[c:5]:[c:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[O&H0&D1:1])=O>>[C:8]-[c&H0&+0&D3:7]1:[n&H1&+0&D2:2]:[c&H0&+0&D3:3](=[O&H0&D1:1]):[c:4]:[c:5]:[n&H0&+0&D2:6]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[NH:7][c:8]1[s:9][c:10]2[CH2:11][CH2:12][CH2:13][CH2:14][c:15]2[c:16]1[C:17]([NH2:18])=[O:19]>O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][c:8]2[s:9][c:10]3[CH2:11][CH2:12][CH2:13][CH2:14][c:15]3[c:16]2[c:17]([nH:18]1)=[O:19]|US05639881A
4.2.2|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O.[C:4]/[C&H0&+0&D3:3](=[N&H0&+0&D2:2]/[#1])-[N&H1&+0&D2:1]-O>>[C:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:5]:[n&H0&+0&D2:1]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:2]:1|[O:1]=[C:2](O)[CH2:3][N:4]1[CH2:5][CH2:6][C:7]([C:8]1=[O:9])([c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[F:16])[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23].O[NH:24]/[C:25]([CH2:26][CH2:27][c:28]1[cH:29][cH:30][c:31]([cH:32][cH:33]1)[Cl:34])=[N:35]\[H]>CCN=C=NCCCN(C)C.CCOC(C)=O.C1COCCO1>[O:9]=[C:8]1[N:4]([CH2:5][CH2:6][C:7]1([c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[F:16])[CH2:3][c:2]1[n:35][c:25]([n:24][o:1]1)[CH2:26][CH2:27][c:28]1[cH:29][cH:30][c:31]([cH:32][cH:33]1)[Cl:34]|US20100179128A1_0854
1.2.14|[C&H3&D1:8]-[C&H0&+0&D4:7]1(-[C:6])-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:8]-[C@@&H0&+0&D4:7](-[C:6])(-[C&H2&+0&D2:5]-[N&H0&+0&D3:2](-[C:3])-[C:1])-[O&H1&+0&D1:4]|[CH3:1][C@H:2]1[CH2:3][NH:4][CH2:5][C@H:6]([O:7]1)[CH3:8].[CH3:9][O:10][c:11]1[c:12]2[N:13]=[C:14]([N:15]3[CH2:16][CH2:17][N:18]=[C:19]3[c:20]2[cH:21][cH:22][c:23]1[O:24][CH2:25][C:26]1([CH2:27][O:28]1)[CH3:29])[NH2:30]>CN(C)C=O>[CH3:9][O:10][c:11]1[c:23]([cH:22][cH:21][c:20]2[C:19]3=[N:18][CH2:17][CH2:16][N:15]3[C:14](=[N:13][c:12]21)[NH2:30])[O:24][CH2:25][C@:26]([CH3:29])([OH:28])[CH2:27][N:4]1[CH2:3][C@@H:2]([O:7][C@@H:6]([CH2:5]1)[CH3:8])[CH3:1]|US10227362B2_1016
4.1.13|[C&H3&D1:8]-[N&H1&+0&D2:7]-[N&H2&+0&D1:6].[C:5]-[C&H0&+0&D3:4](-[c:3]:[c&H0&+0&D3:2](:[c:1])-F)=O>>[C&H3&D1:8]-[n&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:4](-[C:5]):[c:3]:[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][C:2](=[O:3])[N:4]1[CH2:5][CH2:6][CH:7]([CH2:8][CH2:9]1)[C:10](=O)[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1F)[F:17].[CH3:18][NH:19][NH2:20]>CCCCO>[CH3:1][C:2](=[O:3])[N:4]1[CH2:5][CH2:6][CH:7]([CH2:8][CH2:9]1)[c:10]1[n:20][n:19]([c:16]2[cH:15][c:14]([cH:13][cH:12][c:11]12)[F:17])[CH3:18]|US20200029566A1_0731
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H1&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[c:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[n&H0&+0&D3:5](:[c&H1&+0&D2:1]:1)-[c&H0&+0&D3:4](:[c:3]):[c:2]|[CH3:1][CH2:2][CH:3]([CH2:4][CH3:5])[O:6][c:7]1[cH:8][c:9]([n:10][c:11]([c:12]1[NH2:13])[NH:14][c:15]1[c:16]([cH:17][c:18]([cH:19][c:20]1[CH3:21])[CH3:22])[CH3:23])[CH3:24].CO[CH:25](OC)OC>Cc1ccc(cc1)S(=O)(=O)O.Cc1ccccc1.O>[CH3:22][c:18]1[cH:17][c:16]([c:15]([c:20]([cH:19]1)[CH3:21])-[n:14]1[cH:25][n:13][c:12]2[c:7]([cH:8][c:9]([n:10][c:11]21)[CH3:24])[O:6][CH:3]([CH2:4][CH3:5])[CH2:2][CH3:1])[CH3:23]|US20080262021A1_0327
4.1.34|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C:5])=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[c&H0&+0&D3:6](-[C:5]):[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:1|[CH3:1][C:2](=O)[CH2:3][CH2:4][CH2:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.N[NH:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>CC(=O)O>[CH3:1][c:2]1[nH:20][c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]2[c:3]1[CH2:4][CH2:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:12][CH2:13]1)[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|EP1305285B1_0090
4.1.62|[C:8]-[C&H0&+0&D3:7](-O)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H1&+0&D2:6]:[c&H0&+0&D3:5](=[O&H0&D1:4]):[c:3]:[c:2]:[n&H0&+0&D2:1]:1|[CH3:1][CH:2]([CH2:3][CH2:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[n:12]1[n:13][n:14][c:15]([c:16]1[NH2:17])[C:18]([NH2:19])=[O:20].[NH2:21][c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[CH2:28][C:29](=O)O>>[CH3:1][CH:2]([CH2:3][CH2:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[n:12]1[n:13][n:14][c:15]2[c:16]1[n:17][c:29]([nH:19][c:18]2=[O:20])[CH2:28][c:25]1[cH:26][cH:27][c:22]([cH:23][cH:24]1)[NH2:21]|EP3442975B1_0095
4.1.3|[C&H2&+0&D1:8]=[C&H0&+0&D3:7](-[C:6])-[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[C:2]-[N&H2&+0&D1:1]>>[C&H2&+0&D2:8]1-[N&H0&+0&D3:1](-[C:2])-[C&H0&+0&D3:4](=[O&H0&D1:3])-[C:5]-[C&H1&+0&D3:7]-1-[C:6]|[CH2:1]=[C:2]([CH2:3][C:4](=[O:5])O)[C:6](=[O:7])[O:8][CH3:9].[CH3:10][CH:11]([CH3:12])[NH2:13]>CCOCC>[CH3:9][O:8][C:6](=[O:7])[CH:2]1[CH2:3][C:4]([N:13]([CH2:1]1)[CH:11]([CH3:10])[CH3:12])=[O:5]|US09150740B2_0089
3.7.3|[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[#12]-Cl.[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:7]-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-[C&H1&+0&D3:2](-[O&H1&+0&D1:3])-[c:1]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][C:10]([F:11])([F:12])[F:13].[CH3:14][C:15]([CH3:16])([CH3:17])[Mg]Cl>CCOCC.O=S(=O)(O)O.C1CCOC1>[CH3:14][C:15]([CH3:16])([CH3:17])[CH:2]([OH:1])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][C:10]([F:11])([F:12])[F:13]|US20180148453A1_0259
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H1&+0&D2:5]-[c&H0&+0&D3:4](:[n:3]):[n:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[n&H0&+0&D3:5](:[c&H1&+0&D2:1]:1)-[c&H0&+0&D3:4](:[n:3]):[n:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[c:9]([n:10]([c:11]2[n:12][c:13]([n:14][cH:15][c:16]21)[NH:17][c:18]1[cH:19][c:20]([cH:21][cH:22][c:23]1[NH2:24])[C:25]#[N:26])[CH2:27][c:28]1[c:29]([cH:30][cH:31][cH:32][c:33]1[F:34])[F:35])=[O:36].CO[CH:37](OC)OC>Cc1ccc(cc1)S(=O)(=O)O.CO.O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[c:16]2[cH:15][n:14][c:13]([n:12][c:11]2[n:10]([c:9]1=[O:36])[CH2:27][c:28]1[c:29]([cH:30][cH:31][cH:32][c:33]1[F:34])[F:35])-[n:17]1[cH:37][n:24][c:23]2[cH:22][cH:21][c:20]([cH:19][c:18]21)[C:25]#[N:26]|US07902187B2_0332
4.1.70|[C:8]-[C&H0&+0&D3:7](-[c:6]:[c:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](=[O&H0&D1:3]):[c:5]:[c:6]:1|O.[NH2:1][NH2:2].[O:3]=[C:4](O)[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[C:11](=O)[CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1>CCO>[O:3]=[c:4]1[nH:2][n:1][c:11]([c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]21)[CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1|EP3241832A1_0584
4.2.18|[C:8]-[C&H0&+0&D3:7](-O)=O.[N&H2&+0&D1:6]-[c:5]:[c:4]-[C&H0&+0&D3:3](=[O&H0&D1:2])-[O&H1&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c:5]:[c:4]:[c&H0&+0&D3:3](=[O&H0&D1:2]):[o&H0&+0&D2:1]:1|[NH2:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11])[C:12](=[O:13])[OH:14].[CH3:15][C:16]([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[NH:22][CH2:23][C:24](=O)O>CC(C)COC(=O)Cl.CN1CCOCC1.ClCCl.O.Cl>[CH3:15][C:16]([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[NH:22][CH2:23][c:24]1[n:1][c:2]2[c:3]([cH:4][cH:5][cH:6][c:7]2[C:8]([F:9])([F:10])[F:11])[c:12]([o:14]1)=[O:13]|EP0903344A1_0124
4.1.16|[C:9]-[N&H1&+0&D2:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-O)=O>>[C:9]-[n&H0&+0&D3:8]1:[c:7]:[c:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][CH2:2][NH:3][c:4]1[cH:5][cH:6][c:7]2[cH:8][c:9]([cH:10][n:11][c:12]2[c:13]1[NH2:14])[Cl:15].O=[C:16](O)[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23]>O.O=P(O)(O)O.O[Na]>[CH3:1][CH2:2][n:3]1[c:4]2[cH:5][cH:6][c:7]3[cH:8][c:9]([cH:10][n:11][c:12]3[c:13]2[n:14][c:16]1-[c:17]1[cH:22][cH:21][c:20]([cH:19][cH:18]1)[Cl:23])[Cl:15]|US07511145B2_0942
4.1.34|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[S:5])=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[c&H0&+0&D3:6](-[S:5]):[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:1|Cl.[ClH:1].[CH3:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:9]N.[CH3:10][C:11](=O)[CH2:12][S:13][CH:14]1[CH2:15][CH2:16][N:17]([CH2:18][CH2:19]1)[CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>CC(C)O>[ClH:1].[CH3:2][c:3]1[cH:4][c:5]2[c:12]([c:11]([nH:9][c:6]2[cH:7][cH:8]1)[CH3:10])[S:13][CH:14]1[CH2:15][CH2:16][N:17]([CH2:18][CH2:19]1)[CH2:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1|US09260416B2_0505
4.1.36|[N&H2&+0&D1:8]-[c:7]:[c&H1&+0&D2:6]:[c:5].[O&H0&D1:4]=[C&H0&+0&D3:3](-[C&H2&+0&D2:2]-[S:1])-O-C>>[N&H1&+0&D2:8]1-[c:7]:[c&H0&+0&D3:6](:[c:5])-[C&H1&+0&D3:2](-[S:1])-[C&H0&+0&D3:3]-1=[O&H0&D1:4]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8]([F:9])([F:10])[F:11].[CH3:12][S:13][CH2:14][C:15](=[O:16])OC>CCN(CC)CC.CC(C)(C)OCl.ClCCl>[CH3:12][S:13][CH:14]1[C:15]([NH:1][c:2]2[cH:3][cH:4][c:5]([cH:6][c:7]21)[C:8]([F:9])([F:10])[F:11])=[O:16]|US20050075334A1_0256
4.1.16|[C:9]-[C&H0&+0&D3:8](-O)=O.[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[n:2]):[n:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[n:2]):[n:1]|[CH3:1][C:2]([CH3:3])([OH:4])[CH:5]1[CH2:6][CH2:7][N:8]([CH2:9][CH2:10]1)[CH2:11][c:12]1[n:13][c:14]2[c:15]([n:16][c:17]([n:18][c:19]2[n:20]1[CH3:21])[NH:22][c:23]1[cH:24][cH:25][cH:26][cH:27][c:28]1[NH2:29])[N:30]1[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1.[CH3:36][CH2:37][C:38](=O)O>>[CH3:36][CH2:37][c:38]1[n:29][c:28]2[cH:27][cH:26][cH:25][cH:24][c:23]2[n:22]1-[c:17]1[n:16][c:15]([c:14]2[n:13][c:12]([n:20]([c:19]2[n:18]1)[CH3:21])[CH2:11][N:8]1[CH2:7][CH2:6][CH:5]([CH2:10][CH2:9]1)[C:2]([CH3:1])([CH3:3])[OH:4])[N:30]1[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1|US08173650B2_1025
4.1.16|[C:9]-[C&H0&+0&D3:8](=O)-O.[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.O=[C:15](O)[CH2:16][c:17]1[cH:18][cH:19][cH:20][n:21][cH:22]1>O=P(Cl)(Cl)Cl.ClC(Cl)Cl>[cH:20]1[cH:19][cH:18][c:17]([cH:22][n:21]1)[CH2:16][c:15]1[n:1][c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[n:8]1-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1|US09120788B2_0233
1.6.2|[C:9]-[C&H1&+0&D3:8](-[C:7])-Br.[C:6]-[N&H1&+0&D2:5]-[c&H0&+0&D3:4](:[s:3]):[n&H0&+0&D2:2]:[c:1]>>[C:9]-[C&H1&+0&D3:8](-[C:7])-[n&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:4](:[s:3])=[N&H0&+0&D2:5]-[C:6]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[n:10][c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[s:17]1.[CH3:18][CH2:19][O:20][C:21](=[O:22])[CH:23](Br)[CH2:24][CH3:25]>O=C(O[K])O[K].CN(C)C=O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]=[c:9]1[s:17][c:16]2[cH:15][cH:14][cH:13][cH:12][c:11]2[n:10]1[CH:23]([CH2:24][CH3:25])[C:21](=[O:22])[O:20][CH2:19][CH3:18]|US20150011528A1_0828
4.1.45|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H1&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[n&H0&+0&D3:5](:[c&H1&+0&D2:1]:1)-[c&H0&+0&D3:4](:[c:3]):[n:2]|[NH2:1][C:2](=[O:3])[CH2:4][c:5]1[cH:6][n:7][c:8]([cH:9][c:10]1[NH:11][CH2:12][c:13]1[cH:14][c:15]([cH:16][c:17]([cH:18]1)[F:19])[F:20])[NH:21][c:22]1[cH:23][cH:24][cH:25][cH:26][c:27]1[NH2:28].CO[CH:29](OC)OC>Cc1ccc(cc1)S(=O)(=O)O.CO.O>[NH2:1][C:2](=[O:3])[CH2:4][c:5]1[cH:6][n:7][c:8]([cH:9][c:10]1[NH:11][CH2:12][c:13]1[cH:14][c:15]([cH:16][c:17]([cH:18]1)[F:19])[F:20])-[n:21]1[cH:29][n:28][c:27]2[cH:26][cH:25][cH:24][cH:23][c:22]21|US10793551B2_0258
4.1.3|[C&H2&+0&D1:8]=[C&H0&+0&D3:7](-[C:6])-[C:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-O.[N&H2&+0&D1:2]-[c:1]>>[C&H2&+0&D2:8]1-[N&H0&+0&D3:2](-[c:1])-[C&H0&+0&D3:4](=[O&H0&D1:3])-[C:5]-[C&H1&+0&D3:7]-1-[C:6]|[NH2:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)[C:8]([F:9])([F:10])[F:11])[C:12]([F:13])([F:14])[F:15].[CH2:16]=[C:17]([CH2:18][C:19](=[O:20])O)[C:21](=[O:22])[OH:23]>O>[O:20]=[C:19]1[CH2:18][CH:17]([CH2:16][N:1]1[c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)[C:8]([F:9])([F:10])[F:11])[C:12]([F:13])([F:14])[F:15])[C:21](=[O:22])[OH:23]|US20120252792A1_0180
4.1.70|[N&H2&+0&D1:8]-[N&H2&+0&D1:7].[O&H0&D1:6]=[C&H0&+0&D3:5](-[C:4]-[C:3]-[C&H0&+0&D3:2](-[c:1])=O)-O>>[N&H0&+0&D2:8]1-[N&H1&+0&D2:7]-[C&H0&+0&D3:5](=[O&H0&D1:6])-[C:4]-[C:3]-[C&H0&+0&D3:2]=1-[c:1]|O.[NH2:1][NH2:2].[O:3]=[C:4](O)[CH2:5][CH2:6][C:7](=O)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1>CCO>[O:3]=[C:4]1[CH2:5][CH2:6][C:7](=[N:1][NH:2]1)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1|US04886804A
4.1.12|[C&H3&D1:8]-[C&H1&+0&D3:7](-[C&H0&+0&D3:6](-[C:5])=O)-Br.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[n:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D3:2](:[n:1]):[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH:2](Br)[C:3](=O)[C:4]([F:5])([F:6])[F:7].[NH2:8][c:9]1[cH:10][cH:11][c:12]([n:13][n:14]1)[Cl:15]>COCCOC>[CH3:1][c:2]1[c:3]([n:8][c:9]2[cH:10][cH:11][c:12]([n:13][n:14]12)[Cl:15])[C:4]([F:5])([F:6])[F:7]|US20190055196A1_1935
4.2.18|[N&H2&+0&D1:8]-[c:7]:[c:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[O&H1&+0&D1:3].[O:2]-[C&H0&+0&D3:1](-Cl)=O>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[c&H0&+0&D3:5](=[O&H0&D1:4]):[o&H0&+0&D2:3]:[c&H0&+0&D3:1]:1-[O:2]|[CH3:1][CH2:2][O:3][C:4](=O)Cl.[NH2:5][c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[C:12](=[O:13])[OH:14]>CCOC(C)=O.c1ccncc1.C>[CH3:1][CH2:2][O:3][c:4]1[n:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[c:12]([o:14]1)=[O:13]|US20040147739A1_0498
4.1.45|[C:9]-[C&H0&+0&D3:8](-Cl)=O.[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[n:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][n:14]1.O=[C:15](Cl)/[CH:16]=[CH:17]/[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>Cc1ccccc1>[CH:17](=[CH:16]\[c:15]1[n:1][c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[n:8]1-[c:9]1[cH:10][cH:11][cH:12][cH:13][n:14]1)/[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20040181062A1_0446
4.1.45|[C:9]-[C&H0&+0&D3:8](-Cl)=O.[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH:8][c:9]1[cH:10][cH:11][cH:12][n:13][cH:14]1.O=[C:15](Cl)/[CH:16]=[CH:17]/[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>Cc1ccccc1C>[CH:17](=[CH:16]\[c:15]1[n:1][c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[n:8]1-[c:9]1[cH:10][cH:11][cH:12][n:13][cH:14]1)/[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20180118740A1_0809
4.1.12|[C&H3&D1:8]-[C&H1&+0&D3:7](-[C&H0&+0&D3:6](-[C:5])=O)-Br.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH:2](Br)[C:3](=O)[CH2:4][C:5](=[O:6])[O:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[N+:15]([O-:16])=[O:17].[NH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][n:24]1>COCCOC.O=C(O)O[Na]>[CH3:1][c:2]1[c:3]([n:18][c:19]2[cH:20][cH:21][cH:22][cH:23][n:24]12)[CH2:4][C:5](=[O:6])[O:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[N+:15]([O-:16])=[O:17]|US10385069B2_0742
7.6.1|[c:9]-[C&H1&+0&D2:8]=[c&H0&+0&D3:7]1:[c:6]:[c&H0&+0&D3:5](:[n:4]):[c&H0&+0&D3:3](:[c:2]):[c:1]:1>>[c:9]-[C&H2&+0&D2:8]-[C&H1&+0&D3:7]1-[c:6]:[c&H0&+0&D3:5](:[n:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]-1|[O:1]=[c:2]1[nH:3][c:4]2[c:5]3[cH:6][cH:7][cH:8][cH:9][c:10]3[c:11]([c:12]2[n:13]2[cH:14][cH:15][n:16][c:17]12)=[CH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>CO.CN(C)C=O.[H][H].[Pd]>[O:1]=[c:2]1[nH:3][c:4]2-[c:5]3[cH:6][cH:7][cH:8][cH:9][c:10]3[CH:11]([c:12]2[n:13]2[cH:14][cH:15][n:16][c:17]12)[CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|US05807859A
7.9.22|[O:9]-[C&H0&+0&D3:8]1-[c:7]:[c:6]-[S&H0&+0&D3:5](-[C&H0&+0&D3:4]=1-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[O:9]-[c&H0&+0&D3:8]1:[c:7]:[c:6]:[s&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[C:6](=[O:7])[O:8][c:9]1[cH:10][cH:11][c:12]2[C:13](=[C:14]([S:15]([c:16]2[cH:17]1)=O)[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[O:24][CH3:25])[O:26][c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)[O:33][CH2:34][CH2:35][N:36]1[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]1>[Na+].Cl.CCCCCC.CCCO.CCOC(C)=O.[O-]C(=O)O.ClCCl>[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[C:6](=[O:7])[O:8][c:9]1[cH:10][cH:11][c:12]2[c:13]([c:14]([s:15][c:16]2[cH:17]1)-[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[O:24][CH3:25])[O:26][c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)[O:33][CH2:34][CH2:35][N:36]1[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]1|US10604506B2_1529
4.1.62|[C:8]-[C&H0&+0&D3:7](-Cl)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H1&+0&D2:6]:[c&H0&+0&D3:5](=[O&H0&D1:4]):[c:3]:[c:2]:[n&H0&+0&D2:1]:1|[NH2:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[NH2:10].[CH3:11][CH2:12][CH2:13][CH2:14][C:15](=O)Cl>CCN(CC)CC.O=C(O)O[Na].C1CCOC1>[CH3:11][CH2:12][CH2:13][CH2:14][c:15]1[n:10][c:9]2[cH:8][cH:7][cH:6][cH:5][c:4]2[c:2]([nH:1]1)=[O:3]|US20090137549A1_0435
4.2.18|[C:8]-[C&H0&+0&D3:7](-Cl)=O.[N&H2&+0&D1:6]-[c:5]:[c:4]-[C&H0&+0&D3:3](=[O&H0&D1:2])-[O&H1&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c:5]:[c:4]:[c&H0&+0&D3:3](=[O&H0&D1:2]):[o&H0&+0&D2:1]:1|[NH2:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[OH:10])[C:11]([F:12])([F:13])[F:14].O=[C:15](Cl)[CH:16]([Cl:17])[Cl:18]>Cl>[O:9]=[c:8]1[o:10][c:15]([n:1][c:2]2[c:7]1[cH:6][cH:5][cH:4][c:3]2[C:11]([F:12])([F:13])[F:14])[CH:16]([Cl:17])[Cl:18]|US20040235959A1_0237
4.1.12|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-Cl)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Cl)[C:7]([CH3:8])=O.[NH2:9][c:10]1[n:11][cH:12][cH:13][cH:14][c:15]1[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[F:24]>CCCCCC.COCCOC.O=C(O)O[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:7]([n:9][c:10]2[c:15]([cH:14][cH:13][cH:12][n:11]12)[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[F:24])[CH3:8]|EP2914594B1_0259
4.3.8|[C:7]-[C&H0&+0&D2:6]#N.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N&H2&D1:2]):[s&H0&+0&D2:1]:1|N#[C:1][CH2:2][CH2:3][CH:4]1[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1.[NH2:10][C:11](=[S:12])[NH:13][NH2:14]>N.O.O.O=C(O)C(F)(F)F>[NH2:10][c:11]1[n:13][n:14][c:1]([s:12]1)[CH2:2][CH2:3][CH:4]1[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1|US20160297761A1_0480
4.2.3|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[N&H1&+0&D2:4]-[N&H2&+0&D1:3].[S&H0&D1:2]=[C&H0&+0&D2:1]=S>>[C:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:5]:[c&H0&+0&D3:1](:[n&H1&+0&D2:3]:[n&H0&+0&D2:4]:1)=[S&H0&D1:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH:16]=[CH:17][C:18](=[O:19])[NH:20][NH2:21].[S:22]=[C:23]=S>CCO.O[K]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[CH:16]=[CH:17][c:18]1[n:20][nH:21][c:23]([o:19]1)=[S:22]|EP2138482A1_0113
4.3.6|[C&H3&D1:8]-[C&H0&+0&D3:7](-[c:6]:[c&H0&+0&D3:5](:[c:4])-F)=O.[C:3]-[C&H2&+0&D2:2]-[S&H1&+0&D1:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[c&H0&+0&D3:2](-[C:3]):[s&H0&+0&D2:1]:[c&H0&+0&D3:5](:[c:4]):[c:6]:1|[CH3:1][C:2](=O)[c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1F)[C:9]([F:10])([F:11])[F:12].[CH3:13][CH2:14][O:15][C:16](=[O:17])[CH2:18][SH:19]>O=C(O[Cs])O[Cs].CN(C)C=O.O>[CH3:13][CH2:14][O:15][C:16](=[O:17])[c:18]1[s:19][c:8]2[cH:7][cH:6][c:5]([cH:4][c:3]2[c:2]1[CH3:1])[C:9]([F:10])([F:11])[F:12]|US20100041891A1_1500
7.6.1|[c:9]:[c&H0&+0&D3:8]1:[c:7]-[C:6]-[c&H0&+0&D3:5]2:[c:4]:[c:3]:[n&H1&+0&D2:2]:[c&H0&+0&D3:1]:2-1>>[c:9]:[c&H0&+0&D3:8]1:[c:7]-[C:6]-[C@@&H1&+0&D3:5]2-[c:4]:[c:3]-[N&H1&+0&D2:2]-[C@&H1&+0&D3:1]-1-2|[cH:1]1[cH:2][cH:3][cH:4][c:5]2[c:6]1[CH2:7][c:8]1[c:9]3[cH:10][cH:11][cH:12][cH:13][c:14]3[nH:15][c:16]1-2>O.[Na+].CC(=O)O.N#C[BH3-].O[Na]>[cH:12]1[cH:11][cH:10][c:9]2[c:14]([cH:13]1)[NH:15][C@@H:16]1[c:5]3[cH:4][cH:3][cH:2][cH:1][c:6]3[CH2:7][C@H:8]21|EP0409410A1_0056
1.2.14|[C&H3&D1:8]-[C@@&H0&+0&D4:7]1(-[C:6])-[C&H2&+0&D2:5]-[O&H0&+0&D2:4]-1.[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:8]-[C@@&H0&+0&D4:7](-[C:6])(-[C&H2&+0&D2:5]-[n&H0&+0&D3:2](:[c:3]):[c:1])-[O&H1&+0&D1:4]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[O:11][CH2:12][C@:13]1([CH2:14][O:15]1)[CH3:16].[O-:17][N+:18](=[O:19])[c:20]1[cH:21][nH:22][c:23]([n:24]1)[Cl:25]>CC[N+](CC)(CC)Cc1ccccc1.CC#N.[Cl-]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[O:11][CH2:12][C@:13]([CH3:16])([OH:15])[CH2:14][n:22]1[cH:21][c:20]([n:24][c:23]1[Cl:25])[N+:18]([O-:17])=[O:19]|US10017471B2_0749
4.3.6|[C:8]-[C&H2&+0&D2:7]-[S&H1&+0&D1:6].[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:8]-[c&H0&+0&D3:7]1:[s&H0&+0&D2:6]:[c&H0&+0&D3:2](:[c:1]):[c:3]:[c&H0&+0&D3:4]:1-[N&H2&+0&D1:5]|[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1F.[CH3:9][O:10][C:11](=[O:12])[CH2:13][SH:14]>CCN(CC)CC.CS(C)=O.O.O.[Na+].[H-]>[CH3:9][O:10][C:11](=[O:12])[c:13]1[s:14][c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]2[c:2]1[NH2:1]|EP3643711A1_0240
4.3.6|[C:8]-[C&H2&+0&D2:7]-[S&H1&+0&D1:6].[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:8]-[c&H0&+0&D3:7]1:[s&H0&+0&D2:6]:[c&H0&+0&D3:2](:[c:1]):[c:3]:[c&H0&+0&D3:4]:1-[N&H2&+0&D1:5]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][SH:6].[N:7]#[C:8][c:9]1[cH:10][c:11]([cH:12][cH:13][c:14]1Cl)[C:15]#[N:16]>[Na+].[Na+].CO.[O-]C([O-])=O>[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:14]2[cH:13][cH:12][c:11]([cH:10][c:9]2[c:8]1[NH2:7])[C:15]#[N:16]|US20200179377A1_0188
4.3.6|[C:8]-[C&H2&+0&D2:7]-[S&H1&+0&D1:6].[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:8]-[c&H0&+0&D3:7]1:[s&H0&+0&D2:6]:[c&H0&+0&D3:2](:[n:1]):[c:3]:[c&H0&+0&D3:4]:1-[N&H2&+0&D1:5]|[CH3:1][O:2][c:3]1[cH:4][c:5]2[cH:6][c:7]([c:8]([n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14])Cl)[C:15]#[N:16].[NH2:17][C:18](=[O:19])[CH2:20][SH:21]>O.CN(C)C=O.O[K]>[CH3:14][O:13][c:12]1[cH:11][c:10]2[n:9][c:8]3[s:21][c:20]([c:15]([c:7]3[cH:6][c:5]2[cH:4][c:3]1[O:2][CH3:1])[NH2:16])[C:18]([NH2:17])=[O:19]|US20200017525A1_0471
1.7.12|[C:8]-[C&H0&+0&D3:7](-[F&H0&D1:6])=[C&H0&+0&D3:5](-[F&H0&D1:4])-[F&H0&D1:3].[C:2]-[O&H1&+0&D1:1]>>[C:8]-[C&H1&+0&D3:7](-[F&H0&D1:6])-[C&H0&+0&D4:5](-[F&H0&D1:4])(-[F&H0&D1:3])-[O&H0&+0&D2:1]-[C:2]|[F:1][C:2]([F:3])=[C:4]([F:5])[C:6]([F:7])([F:8])[F:9].[OH:10][CH2:11][C:12]([F:13])([F:14])[F:15]>O[K]>[F:7][C:6]([F:8])([F:9])[CH:4]([F:5])[C:2]([F:1])([F:3])[O:10][CH2:11][C:12]([F:13])([F:14])[F:15]|US20090326083A1_0052
1.7.12|[C:8]-[C&H0&+0&D3:7](-[F&H0&D1:6])=[C&H0&+0&D3:5](-[F&H0&D1:4])-[F&H0&D1:3].[O&H1&+0&D1:2]-[c:1]>>[C:8]-[C&H1&+0&D3:7](-[F&H0&D1:6])-[C&H0&+0&D4:5](-[F&H0&D1:4])(-[F&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[OH:11].[F:12][C:13]([F:14])=[C:15]([F:16])[C:17]([F:18])([F:19])[F:20]>CC(C)=O.O[K]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][C:13]([F:12])([F:14])[CH:15]([F:16])[C:17]([F:18])([F:19])[F:20]|EP0975569B1_0031
1.7.12|[F&H0&D1:8]-[C&H0&+0&D3:7](-[O:6])=[C&H0&+0&D3:5](-[F&H0&D1:4])-[F&H0&D1:3].[O&H1&+0&D1:2]-[c:1]>>[F&H0&D1:8]-[C&H1&+0&D3:7](-[O:6])-[C&H0&+0&D4:5](-[F&H0&D1:4])(-[F&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[F:1][C:2]([F:3])=[C:4]([F:5])[O:6][C:7]([F:8])([F:9])[C:10]([F:11])([F:12])[C:13]([F:14])([F:15])[F:16].[CH3:17][O:18][C:19](=[O:20])[c:21]1[cH:22][c:23]([cH:24][c:25]([cH:26]1)[OH:27])[C:28](=[O:29])[O:30][CH3:31]>CC(C)(C)[O-].C1CCOC1.[K+]>[CH3:17][O:18][C:19](=[O:20])[c:21]1[cH:22][c:23]([cH:24][c:25]([cH:26]1)[O:27][C:2]([F:1])([F:3])[CH:4]([F:5])[O:6][C:7]([F:9])([F:8])[C:10]([F:11])([F:12])[C:13]([F:14])([F:15])[F:16])[C:28](=[O:29])[O:30][CH3:31]|US20200199096A1_0296
2.1.2|[N&H2&+0&D1:8]-[c:7].[O&H0&D1:6]=[C&H0&+0&D3:5](-[C&H1&+0&D3:4]1-[C:3]-[C&H1&+0&D3:2]-1-[c:1])-O>>[N&H1&+0&D2:8](-[c:7])-[C&H0&+0&D3:5](=[O&H0&D1:6])-[C@@&H1&+0&D3:4]1-[C:3]-[C@&H1&+0&D3:2]-1-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[NH2:9])[Cl:10].[O:11]=[C:12](O)[CH:13]1[CH2:14][CH:15]1[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[NH:9][C:12](=[O:11])[C@@H:13]1[CH2:14][C@H:15]1[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[Cl:10]|US20200196607A1_2260
4.2.3|[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[N&H1&+0&D2:4]-[N&H1&+0&D2:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:5]:[c&H0&+0&D3:2](-[C:1]):[n&H0&+0&D2:3]:[n&H0&+0&D2:4]:1|[CH3:1][C:2](=[O:3])[NH:4][NH:5][C:6](=O)[CH2:7][n:8]1[n:9][c:10]([c:11]([c:12]1[CH2:13][CH3:14])[O:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[C:22]#[N:23])[CH2:24][CH3:25]>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCN(CC)CC.ClCCl.II>[CH3:14][CH2:13][c:12]1[c:11]([c:10]([n:9][n:8]1[CH2:7][c:6]1[n:5][n:4][c:2]([o:3]1)[CH3:1])[CH2:24][CH3:25])[O:15][c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[C:22]#[N:23]|EP2575473B1_0244
4.2.3|[C&H3&D1:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1])=O>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:1]:[c&H0&+0&D3:3](-[C:2]):[n&H0&+0&D2:4]:[n&H0&+0&D2:5]:1|[CH3:1][C:2](=O)[NH:3][NH:4][C:5](=[O:6])[C@@H:7]1[CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[S:13](=[O:14])(=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22]>>[CH3:1][c:2]1[n:3][n:4][c:5]([o:6]1)[C@@H:7]1[CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[S:13](=[O:14])(=[O:15])[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[F:22]|US20200181104A1_0589
4.1.40|[C:8]-[C&H0&+0&D2:7]#[N&H0&+0&D1:6].[N&H2&+0&D1:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&+0&D1:1])-O-C>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:2](-[O&H1&+0&D1:1]):[c:3]:[c:4]:[n&H0&+0&D2:5]:1|CO[C:1](=[O:2])[c:3]1[s:4][cH:5][cH:6][c:7]1[NH2:8].[N:9]#[C:10][CH:11]1[CH2:12][CH2:13]1>C1COCCO1.[NH4+].O.Cl.[OH-]>[OH:2][c:1]1[n:9][c:10]([n:8][c:7]2[cH:6][cH:5][s:4][c:3]21)[CH:11]1[CH2:12][CH2:13]1|US10865216B2_0639
4.1.71|[C:8]-[N&H2&+0&D1:7].[N&H0&+0&D1:6]#[C&H0&+0&D2:5]-[c:4]:[c:3]-[N&H0&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C>>[C:8]-[N&H1&+0&D2:7]-[c&H0&+0&D3:5]1:[n&H0&+0&D2:6]:[c&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c:3]:[c:4]:1|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[NH:8][c:9]1[n:10][nH:11][c:12]([c:13]1[C:14]#[N:15])[N:16]=[CH:17]N(C)C.[NH2:18][CH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[NH:8][c:9]1[n:10][nH:11][c:12]2[n:16][cH:17][n:15][c:14]([c:13]21)[NH:18][CH2:19][c:20]1[cH:25][cH:24][cH:23][cH:22][cH:21]1|US09546165B2_0497
4.1.45|[c:8]:[c&H0&+0&D3:7](:[c:6])-[C&H1&+0&D2:5]=O.[c:4](:[c:3]-[N&H0&+&D3:2](-[O&-])=O)-[N&H0&+&D3:1](-[O&-])=O>>[c:8]:[c&H0&+0&D3:7](:[c:6])-[c&H0&+0&D3:5]1:[n&H1&+0&D2:2]:[c:3]:[c:4]:[n&H0&+0&D2:1]:1|[CH3:1][n:2]1[cH:3][n:4][c:5]2[cH:6][c:7]([c:8]([cH:9][c:10]21)[N+:11]([O-])=O)[N+:12]([O-])=O.O=[CH:13][c:14]1[cH:15][cH:16][n:17][cH:18][cH:19]1>Cl.CCO.O=[Pt]=O.[H][H]>[CH3:1][n:2]1[cH:3][n:4][c:5]2[cH:6][c:7]3[nH:12][c:13]([n:11][c:8]3[cH:9][c:10]21)-[c:14]1[cH:19][cH:18][n:17][cH:16][cH:15]1|US09144557B2_1889
4.3.8|[C:7]-[C&H0&+0&D3:6](-[N&H1&+0&D2:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1])=O>>[C:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](-[N&H2&D1:2]):[n&H0&+0&D2:4]:[n&H0&+0&D2:5]:1|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12](=O)[NH:13][NH:14][C:15]([NH2:16])=[S:17]>Cc1ccccc1.CS(=O)(=O)O>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][c:12]1[n:13][n:14][c:15]([s:17]1)[NH2:16]|US20100120669A1_0547
4.2.16|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1])=O>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:1]:[c&H0&+0&D3:3](-[C:2]):[n&H0&+0&D2:4]:[c&H1&+0&D2:5]:1|[CH3:1][C:2](=O)[CH2:3][NH:4][C:5](=[O:6])[C:7]1([CH2:8][CH2:9]1)[Br:10]>O=S(=O)(O)O.[O-]C([O-])=O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+]>[CH3:1][c:2]1[cH:3][n:4][c:5]([o:6]1)[C:7]1([CH2:8][CH2:9]1)[Br:10]|US20200010415A1_1006
4.2.2|[C&H3&D1:7]-[C&H0&+0&D3:6](-[N&H2&+0&D1:5])=[N&H0&+0&D2:4]-O.[C:3]-[C&H0&+0&D3:2](=[O&H0&+0&D1:1])-O>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[c&H0&+0&D3:2](-[C:3]):[o&H0&+0&D2:1]:[n&H0&+0&D2:4]:1|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][C:12](=[O:13])O.[CH3:14][C:15]([NH2:16])=[N:17]O>CN(C)C=O.O=C(n1ccnc1)n1ccnc1>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:10][cH:9][c:8]([cH:7][cH:6]1)[CH2:11][c:12]1[n:16][c:15]([n:17][o:13]1)[CH3:14]|US10577382B2_1074
4.3.8|[C:7]-[C&H0&+0&D3:6](-O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N&H2&D1:2]):[s&H0&+0&D2:1]:1|[CH3:1][O:2][CH2:3][C:4](=O)O.[NH2:5][C:6](=[S:7])[NH:8][NH2:9]>O>[CH3:1][O:2][CH2:3][c:4]1[n:9][n:8][c:6]([s:7]1)[NH2:5]|US20200377493A1_0944
4.2.2|[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O.[C:4]-[C&H0&+0&D3:3](=[N&H1&+0&D1:2])-[N&H1&+0&D2:1]-O>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:1]:[o&H0&+0&D2:5]:1|[CH3:1][C:2](=[O:3])O.[CH3:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[S:11](=[O:12])(=[O:13])[N:14]1[CH:15]([CH2:16][CH2:17][CH:18]1[C:19](=[NH:20])[NH:21]O)[c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28]>CN(C)C=O.O=C(n1cncc1)n1cncc1>[CH3:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[S:11](=[O:12])(=[O:13])[N:14]1[CH:15]([CH2:16][CH2:17][CH:18]1[c:19]1[n:20][c:2]([o:3][n:21]1)[CH3:1])[c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28]|US08329904B2_0891
4.3.20|[C:8]-[C&H0&+0&D3:7](-[c:6])=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](=[S&H0&+0&D1:2])-[c:1]>>[C:8]-[C&H0&+0&D4:7]1(-[N&H1&+0&D2:5]-[N&H0&+0&D2:4]=[C&H0&+0&D3:3](-[S&H0&+0&D2:2]-1)-[c:1])-[c:6]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][CH2:10][CH2:11][C:12](=O)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[NH2:19][NH:20][C:21](=[S:22])[c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[F:29]>CCO.ClCCl>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][CH2:10][CH2:11][C:12]1([NH:19][N:20]=[C:21]([S:22]1)[c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[F:29])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US20140221412A1_0256
4.1.114|[C:7]-[C&H0&+0&D3:6](-[N&H2&+0&D1:5])=[N&H0&+0&D2:4]-[N&H1&+0&D2:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[C:7]-[c&H0&+0&D3:6]1:[n&H1&+0&D2:5]:[c&H0&+0&D3:2](=[O&H0&D1:1]):[n&H1&+0&D2:3]:[n&H0&+0&D2:4]:1|[CH3:1][C@@H:2]([O:3][C@H:4]1[O:5][CH2:6][CH2:7][N:8]([C@H:9]1[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[F:16])[CH2:17][C:18]([NH2:19])=[N:20][NH:21][C:22](=[O:23])OC)[c:24]1[cH:25][c:26]([cH:27][c:28]([cH:29]1)[C:30]([F:31])([F:32])[F:33])[C:34]([F:35])([F:36])[F:37]>>[CH3:1][C@@H:2]([O:3][C@H:4]1[O:5][CH2:6][CH2:7][N:8]([C@H:9]1[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[F:16])[CH2:17][c:18]1[n:20][nH:21][c:22]([nH:19]1)=[O:23])[c:24]1[cH:25][c:26]([cH:27][c:28]([cH:29]1)[C:30]([F:31])([F:32])[F:33])[C:34]([F:35])([F:36])[F:37]|
4.3.6|[S&H1&+0&D1:8]-[C&H2&+0&D2:7]-[C:6]-[O&H0&+0&D2:5]-C.[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-F>>[s&H0&+0&D2:8]1:[c&H0&+0&D3:7](:[c&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:3]:1:[c:4])-[C:6]-[O&H1&+0&D1:5]|C[O:1][C:2](=[O:3])[CH2:4][SH:5].O=[CH:6][c:7]1[cH:8][c:9]([cH:10][cH:11][c:12]1F)[Br:13]>CCC(=O)c1ccc2sccc2c1>[O:3]=[C:2]([OH:1])[c:4]1[cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[s:5]1)[Br:13]|US10730849B2_0631
4.1.71|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c:6]:[c:5]/[N&H0&+0&D2:4]=[C&H1&+0&D2:3]/N(-C)-C.[N&H2&+0&D1:2]-[c:1]>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:7](-[N&H1&+0&D2:2]-[c:1]):[c:6]:[c:5]:[n&H0&+0&D2:4]:[c&H1&+0&D2:3]:1|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[NH2:11].[CH3:12][CH:13]([CH3:14])[c:15]1[cH:16][cH:17][c:18]([c:19]([n:20]1)/[N:21]=[CH:22]/N(C)C)[C:23]#[N:24]>O.CC(=O)O>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[NH:11][c:23]1[n:24][cH:22][n:21][c:19]2[n:20][c:15]([cH:16][cH:17][c:18]21)[CH:13]([CH3:12])[CH3:14]|US20200190091A1_0417
4.2.2|[C&H3&D1:7]-[C&H0&+0&D3:6](=[N&H1&+0&D1:5])-[N&H1&+0&D2:4]-O.[C:3]-[C&H0&+0&D3:2](=[O&H0&+0&D1:1])-O>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[c&H0&+0&D3:2](-[C:3]):[o&H0&+0&D2:1]:[n&H0&+0&D2:4]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH2:8][C@@H:9]([CH2:10][CH2:11][CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[C:19](=[O:20])O.[CH3:21][C:22](=[NH:23])[NH:24]O>O=C(n1ccnc1)n1ccnc1.ClCCl>[CH3:21][c:22]1[n:23][c:19]([o:20][n:24]1)[C@H:9]([CH2:10][CH2:11][CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US07030118B2_0144
4.1.71|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c:6]:[c:5]-[N&H0&+0&D2:4]=[C&H1&+0&D2:3]-N(-C)-C.[N&H2&+0&D1:2]-[c:1]>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:7](-[N&H1&+0&D2:2]-[c:1]):[c:6]:[c:5]:[n&H0&+0&D2:4]:[c&H1&+0&D2:3]:1|CN(C)[CH:1]=[N:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[C:9]#[N:10])[N+:11]([O-:12])=[O:13].[NH2:14][c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[Br:21]>CC(=O)O>[O-:12][N+:11](=[O:13])[c:6]1[cH:5][cH:4][c:3]2[n:2][cH:1][n:10][c:9]([c:8]2[cH:7]1)[NH:14][c:15]1[cH:20][c:19]([cH:18][cH:17][cH:16]1)[Br:21]|US10828305B2_0330
4.2.2|[C&H3&D1:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[N&H0&+0&D2:1]-O>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:1]:[o&H0&+0&D2:5]:1|[CH3:1][C:2](=[O:3])O.[CH3:4][n:5]1[c:6]2[n:7][cH:8][n:9]([c:10]2[c:11]([n:12]([c:13]1=[O:14])[CH3:15])=[O:16])[CH2:17][C:18]([NH2:19])=[N:20]O>CC(=O)OC(C)=O>[CH3:15][n:12]1[c:13]([n:5]([c:6]2[n:7][cH:8][n:9]([c:10]2[c:11]1=[O:16])[CH2:17][c:18]1[n:19][c:2]([o:3][n:20]1)[CH3:1])[CH3:4])=[O:14]|US09409866B2_0902
4.3.3|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Br)=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N&H2&D1:2]):[s&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|[NH2:1][C:2]([NH2:3])=[S:4].[O:5]=[C:6]([OH:7])[C:8](=O)[CH2:9]Br>c1cscn1>[NH2:1][c:2]1[n:3][c:8]([cH:9][s:4]1)[C:6](=[O:5])[OH:7]|EP3556755A1_0118
4.3.3|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Cl)=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N&H2&D1:2]):[s&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|[CH3:1][O:2][N:3]=[C:4]([C:5](=[O:6])[O:7][CH2:8][CH3:9])[C:10](=O)[CH2:11]Cl.[NH2:12][C:13]([NH2:14])=[S:15]>O.[Na+].CO.CC([O-])=O.O=C(O)O[Na]>[CH3:9][CH2:8][O:7][C:5](=[O:6])[C:4](=[N:3][O:2][CH3:1])[c:10]1[cH:11][s:15][c:13]([n:14]1)[NH2:12]|EP0257275A2_0036
4.3.3|[C:7]-[C&H1&+0&D3:6](-[C&H1&+0&D2:5]=O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H1&+0&D2:5]:1)-[N&H2&D1:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7](Br)[CH:8]=O.[NH2:9][C:10]([NH2:11])=[S:12]>CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][n:11][c:10]([s:12]1)[NH2:9]|EP1640369A1_0141
4.3.3|[C&H3&D1:7]-[C&H0&+0&D3:6](-[N&H2&+0&D1:5])=[S&H0&+0&D1:4].[C:3]-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[c&H0&+0&D3:2](-[C:3]):[c&H1&+0&D2:1]:[s&H0&+0&D2:4]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[N:7][OH:8])[C:9](=O)[CH2:10]Br.[CH3:11][C:12]([NH2:13])=[S:14]>CCN(CC)CC.c1ccccc1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[N:7][OH:8])[c:9]1[cH:10][s:14][c:12]([n:13]1)[CH3:11]|EP1612204A1_0306
4.3.3|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Cl)=O.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[S&H0&+0&D1:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[s&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|[CH3:1][O:2][C:3](=[O:4])[C:5]1=[C:6]([NH:7][C:8](=[C:9]([CH:10]1[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17])[C:18](=[O:19])[O:20][CH2:21][CH3:22])[CH2:23][O:24][CH2:25][C:26]([NH2:27])=[S:28])[CH3:29].[CH3:30][C:31](=O)[CH2:32]Cl>CCO>[CH3:30][c:31]1[cH:32][s:28][c:26]([n:27]1)[CH2:25][O:24][CH2:23][C:8]1[NH:7][C:6](=[C:5]([CH:10]([C:9]=1[C:18](=[O:19])[O:20][CH2:21][CH3:22])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17])[C:3](=[O:4])[O:2][CH3:1])[CH3:29]|US20190084975A1_0283
4.2.22|[C&H1&+0&D1:8]#[C&H0&+0&D2:7]-[C:6].[C:5]-[C&H0&+0&D3:4](=[C&H0&+0&D3:3](-[C:2])-[O&H1&+0&D1:1])-Br>>[c&H1&+0&D2:8]1:[c&H0&+0&D3:7](-[C:6]):[o&H0&+0&D2:1]:[c&H0&+0&D3:3](-[C:2]):[c&H0&+0&D3:4]:1-[C:5]|[CH:1]#[C:2][C:3]1([O:4][CH2:5][CH2:6][O:7]1)[CH3:8].[O:9]=[C:10]1[C:11](=[C:12]([C:13]([c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]12)=[O:20])Br)[OH:21]>c1ccncc1.O([Cu])[Cu]>[CH3:8][C:3]1([O:4][CH2:5][CH2:6][O:7]1)[c:2]1[cH:1][c:12]2[C:13]([c:14]3[cH:15][cH:16][cH:17][cH:18][c:19]3[C:10]([c:11]2[o:21]1)=[O:9])=[O:20]|US20190062294A1_0398
4.1.71|[N&H1&+0&D1:8]=[C&H0&+0&D3:7](-[N&H2&+0&D1:6])-[N:5].[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-Br>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:7](:[n&H0&+0&D2:6]:[c&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:3]:1:[c:4])-[N:5]|[CH3:1][n:2]1[c:3]([c:4]2[cH:5][c:6]([cH:7][cH:8][c:9]2[c:10]([c:11]1[CH:12]=O)Br)[N+:13]([O-:14])=[O:15])=[O:16].[NH:17]=[C:18]([NH2:19])[NH:20][c:21]1[cH:22][cH:23][cH:24][c:25]([cH:26]1)[NH2:27]>O.CN(C)C=O.[O-]C([O-])=O.[K+].[K+]>[CH3:1][n:2]1[c:11]2[cH:12][n:19][c:18]([n:17][c:10]2[c:9]2[cH:8][cH:7][c:6]([cH:5][c:4]2[c:3]1=[O:16])[N+:13]([O-:14])=[O:15])[NH:20][c:21]1[cH:22][cH:23][cH:24][c:25]([cH:26]1)[NH2:27]|US09944641B2_0488
4.1.45|[C:9]-[N&H1&+0&D2:8]-[c:7]:[c:6]-[N&H0&+&D3:5](-[O&-])=O.[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[C:9]-[n&H0&+0&D3:8]1:[c&H0&+0&D3:1](:[n&H0&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|[O-][N+:1](=O)[c:2]1[cH:3][cH:4][cH:5][c:6]2[C:7]([NH:8][C@H:9]([CH2:10][NH:11][c:12]21)[CH2:13][O:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)=[O:22].O=[CH:23][c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[CH2:30][OH:31]>CO.CC(=O)N(C)C.O=S(O)O[Na].[H][H].[Pd]>[O:22]=[C:7]1[NH:8][C@H:9]([CH2:10][n:11]2[c:12]3[c:6]1[cH:5][cH:4][cH:3][c:2]3[n:1][c:23]2-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[CH2:30][OH:31])[CH2:13][O:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20200039953A1_0623
4.3.3|[C&H3&D1:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-Cl)=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C&H3&D1:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N:2]):[s&H0&+0&D2:1]:[c&H1&+0&D2:5]:1|[CH3:1][C:2](=O)[CH2:3]Cl.[NH2:4][C:5](=[S:6])[NH:7][CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][CH:13]([CH2:14][CH2:15]1)[NH:16][c:17]1[n:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[n:25]1[CH2:26][c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)[F:33]>O=C(O[K])O[K].C1CCOC1>[CH3:1][c:2]1[cH:3][s:6][c:5]([n:4]1)[NH:7][CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([CH2:12][CH2:11]1)[NH:16][c:17]1[n:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[n:25]1[CH2:26][c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)[F:33]|EP3511323A1_1573
4.1.59|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-[C&H0&+0&D2:4]#[N&H0&+0&D1:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](-[N&H2&+0&D1:3]):[c&H1&+0&D2:5]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=O)[CH2:6][C:7]#[N:8].[NH2:9][NH2:10]>CCO>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([nH:10][n:9]1)[NH2:8]|US20190248774A1_0887
4.1.59|[C:7]-[C&H1&+0&D3:6](-[C&H0&+0&D2:5]#[N&H0&+0&D1:4])-[C&H1&+0&D2:3]=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[c&H0&+0&D3:5](-[N&H2&+0&D1:4]):[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c&H1&+0&D2:3]:1|O.[CH3:1][CH:2]([CH3:3])[CH:4]([C:5]#[N:6])[CH:7]=O.[NH2:8][NH2:9]>CCO.CC(=O)O>[CH3:1][CH:2]([CH3:3])[c:4]1[cH:7][n:8][nH:9][c:5]1[NH2:6]|US20200331917A1_0875
4.1.59|[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-[C&H0&+0&D2:4]#[N&H0&+0&D1:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:7]-[c&H0&+0&D3:6]1:[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:4](-[N&H2&+0&D1:3]):[c&H1&+0&D2:5]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=O)[CH2:6][C:7]#[N:8].[NH2:9][NH2:10].O>CC(C)O>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([n:9][nH:10]1)[NH2:8]|US20170008877A1_3284
4.2.3|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[N&H1&+0&D2:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-Cl)-Cl>>[C:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:5]:[c&H0&+0&D3:1](:[n&H1&+0&D2:3]:[n&H0&+0&D2:4]:1)=[O&H0&D1:2]|[CH3:1][C:2]1([CH2:3][CH2:4]1)[C:5](=[O:6])[NH:7][NH2:8].[O:9]=[C:10](Cl)Cl>CCOC(C)=O>[CH3:1][C:2]1([CH2:3][CH2:4]1)[c:5]1[n:7][nH:8][c:10]([o:6]1)=[O:9]|US09221784B2_0431
4.1.8|[C:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D3:4](-[C:3])=O)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](-[C:3]):[c&H0&+0&D3:6]:1-[C:5]|O.[CH3:1][CH2:2][C:3](=O)[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][O:11][c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1[Cl:18])[O:19][CH3:20])[C:21](=O)[CH2:22][CH3:23].[NH2:24][NH2:25]>CO>[CH3:20][O:19][c:15]1[cH:14][cH:13][c:12]([c:17]([cH:16]1)[Cl:18])[O:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][c:4]1[c:21]([n:24][nH:25][c:3]1[CH2:2][CH3:1])[CH2:22][CH3:23]|US20200010477A1_0469
4.1.8|[C:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C&H0&+0&D3:5](-[C:4])=O)=O.[C:3]-[N&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:1]:[n&H0&+0&D3:2](-[C:3]):[c&H0&+0&D3:5](-[C:4]):[c&H1&+0&D2:6]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7][C:8](=O)[CH2:9][CH3:10].[CH3:11][CH2:12][NH:13][NH2:14].O=C(O)C(=O)O>CC(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([n:13]([n:14]1)[CH2:12][CH3:11])[CH2:9][CH3:10]|US20100167931A1_0552
4.1.46|[C&H3&D1:7]-[N&H1&+0&D2:6]-[c:5]:[c:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[C&H3&D1:7]-[n&H0&+0&D3:6]1:[c:5]:[c:4]:[n&H1&+0&D2:3]:[c&H0&+0&D3:1]:1=[O&H0&D1:2]|[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[S:8][c:9]1[cH:10][c:11]([c:12]([cH:13][c:14]1[Cl:15])[NH2:16])[NH:17][CH3:18].[O:19]=[C:20](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>CCN(CC)CC.C1CCOC1>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[S:8][c:9]1[cH:10][c:11]2[c:12]([cH:13][c:14]1[Cl:15])[nH:16][c:20]([n:17]2[CH3:18])=[O:19]|US20200165227A1_0288
4.3.3|[C:8]-[C&H1&+0&D3:7](-[C&H0&+0&D3:6](-[C:5])=O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[C:5])-[N:2]|[CH3:1][NH:2][C:3]([NH2:4])=[S:5].[CH3:6][C:7]1([CH2:8][C:9]([CH:10]([C:11]([CH2:12]1)=[O:13])Br)=O)[CH3:14]>[Na+].CC([O-])=O.CC(=O)O>[CH3:6][C:7]1([CH2:12][C:11]([c:10]2[s:5][c:3]([n:4][c:9]2[CH2:8]1)[NH:2][CH3:1])=[O:13])[CH3:14]|US10336775B2_0783
4.3.6|[C:8]-[C&H2&+0&D2:7]-[S&H1&+0&D1:6].[C:5]-[C&H0&+0&D3:4](=[C&H0&+0&D3:3](-[C:2])-[C&H1&+0&D2:1]=O)-Cl>>[C:8]-[c&H0&+0&D3:7]1:[s&H0&+0&D2:6]:[c&H0&+0&D3:4](-[C:5]):[c&H0&+0&D3:3](-[C:2]):[c&H1&+0&D2:1]:1|O=[CH:1][C:2]1[CH2:3][CH2:4][N:5]([CH2:6][CH2:7][C:8]=1Cl)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH3:16][CH2:17][O:18][C:19](=[O:20])[CH2:21][SH:22].Cl>CCN(CC)CC.c1ccncc1.O[K]>[CH3:16][CH2:17][O:18][C:19](=[O:20])[c:21]1[cH:1][c:2]2[CH2:3][CH2:4][N:5]([CH2:6][CH2:7][c:8]2[s:22]1)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US08716274B2_1198
1.7.13|[C&H3&D1:8]-[C&H1&+0&D3:7](-[C&H3&D1:6])-I.[O&H0&+0&D1:5]=[c&H0&+0&D3:4](:[c:3]):[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:8]-[C&H1&+0&D3:7](-[C&H3&D1:6])-[O&H0&+0&D2:5]-[c&H0&+0&D3:4](:[c:3]):[n&H0&+0&D2:2]:[c:1]|[CH3:1][CH:2]([CH3:3])I.[CH3:4][CH2:5][O:6][C:7](=[O:8])[C:9]1=[C:10]([NH:11][c:12]2[cH:13][cH:14][nH:15][c:16]([c:17]2[CH:18]1[c:19]1[cH:20][cH:21][cH:22][s:23]1)=[O:24])[CH3:25]>CN(C)C=O.[NaH]>[CH3:4][CH2:5][O:6][C:7](=[O:8])[C:9]1=[C:10]([NH:11][c:12]2[cH:13][cH:14][n:15][c:16]([c:17]2[CH:18]1[c:19]1[cH:20][cH:21][cH:22][s:23]1)[O:24][CH:2]([CH3:1])[CH3:3])[CH3:25]|US20130012491A1_0174
7.6.1|[C:9]-[c&H0&+0&D3:8]1:[c&H0&+0&D3:7](=[O&H0&D1:6]):[n&H1&+0&D2:5]:[c:4]:[c:3]:[c&H0&+0&D3:2]:1-[C:1]>>[C:9]-[C&H1&+0&D3:8]1-[C&H0&+0&D3:7](=[O&H0&D1:6])-[N&H1&+0&D2:5]-[c:4]:[c:3]-[C&H1&+0&D3:2]-1-[C:1]|[O:1]=[c:2]1[nH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]2[CH2:11][CH2:12][CH2:13][c:14]21>CO.[Mg]>[O:1]=[C:2]1[NH:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[CH:10]2[CH2:11][CH2:12][CH2:13][CH:14]12|EP1054869B1_0152
4.2.3|[C:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[N&H1&+0&D2:4]-[N&H2&+0&D1:3].[N&H0&+0&D1:2]#[C&H0&+0&D2:1]-Br>>[C:7]-[c&H0&+0&D3:6]1:[o&H0&+0&D2:5]:[c&H0&+0&D3:1](-[N&H2&+0&D1:2]):[n&H0&+0&D2:3]:[n&H0&+0&D2:4]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[S:16][CH2:17][CH2:18][C:19](=[O:20])[NH:21][NH2:22].[N:23]#[C:24]Br>CCOC(C)=O.C1COCCO1.O=C(O)O[Na].O>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[S:16][CH2:17][CH2:18][c:19]1[n:21][n:22][c:24]([o:20]1)[NH2:23]|US20130005721A1_0421
4.3.3|[C:8]-[C&H1&+0&D3:7](-[C&H0&+0&D3:6](-[C:5])=O)-Br.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[S&H0&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:2]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH:2]([CH3:3])[C:4]([NH2:5])=[S:6].[CH3:7][O:8][C:9](=[O:10])[CH2:11][CH:12](Br)[C:13](=O)[CH2:14][O:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>O.CO.O=C(O)O[Na]>[CH3:7][O:8][C:9](=[O:10])[CH2:11][c:12]1[s:6][c:4]([n:5][c:13]1[CH2:14][O:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[CH:2]([CH3:1])[CH3:3]|US20120065196A1_1035
4.3.3|[C:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-Cl)=O.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[S&H0&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[s&H0&+0&D2:1]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][O:2][CH2:3][C:4]([NH2:5])=[S:6].[CH3:7][CH2:8][CH2:9][C:10](=O)[CH:11](Cl)[CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[N+:19]([O-:20])=[O:21]>CCOC(C)=O.C>[CH3:7][CH2:8][CH2:9][c:10]1[n:5][c:4]([s:6][c:11]1[CH2:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[N+:19]([O-:20])=[O:21])[CH2:3][O:2][CH3:1]|US20090286814A1_0105
2.3.8|[O&H0&D1:8]=[C&H0&+0&D3:7](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl.[c:6]-[N&H1&+0&D2:5]-[C:4]-[C:3]-[N&H1&+0&D2:2]-[c:1]>>[O&H0&D1:8]=[C&H0&+0&D3:7]1-[N&H0&+0&D3:5](-[c:6])-[C:4]-[C:3]-[N&H0&+0&D3:2]-1-[c:1]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])[NH:11][S:12](=[O:13])(=[O:14])[c:15]1[cH:16][cH:17][c:18]2[cH:19][cH:20][c:21]([cH:22][c:23]2[cH:24]1)[NH:25][CH2:26][CH2:27][NH:28][c:29]1[cH:30][cH:31][c:32]2[cH:33][cH:34][c:35]([cH:36][c:37]2[cH:38]1)[S:39](=[O:40])(=[O:41])[NH:42][c:43]1[cH:44][cH:45][c:46]([c:47]([cH:48]1)[C:49](=[O:50])[OH:51])[OH:52].[O:53]=[C:54](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>O=C(O[Na])O[Na].C1CCOC1.CS(C)=O.CC#N.O.O.Cl>[O:1]=[C:2]([OH:3])[c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[OH:10])[NH:11][S:12](=[O:13])(=[O:14])[c:15]1[cH:16][cH:17][c:18]2[cH:19][cH:20][c:21]([cH:22][c:23]2[cH:24]1)[N:25]1[CH2:26][CH2:27][N:28]([C:54]1=[O:53])[c:29]1[cH:30][cH:31][c:32]2[cH:33][cH:34][c:35]([cH:36][c:37]2[cH:38]1)[S:39](=[O:40])(=[O:41])[NH:42][c:43]1[cH:44][cH:45][c:46]([c:47]([cH:48]1)[C:49](=[O:50])[OH:51])[OH:52]|US10562859B2_0373
4.1.40|[C&H3&D1:8]-[C&H0&+0&D2:7]#[N&H0&+0&D1:6].[N&H2&+0&D1:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H1&+0&D2:6]:[c&H0&+0&D3:2](=[O&H0&D1:1]):[c:3]:[c:4]:[n&H0&+0&D2:5]:1|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[NH2:11])[C:12](=[O:13])OC.[CH3:14][C:15]#[N:16]>Cl.C1COCCO1>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[n:11][c:15]([nH:16][c:12]2=[O:13])[CH3:14]|US10500205B2_0170
4.1.45|[C&H3&D1:9]-[N&H1&+0&D2:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[C&H3&D1:9]-[n&H0&+0&D3:8]1:[c&H0&+0&D3:1](:[n&H0&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][NH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[NH2:9])[CH2:10][N:11]1[CH2:12][CH2:13][N:14]([CH2:15][CH2:16]1)[CH:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1.O=[CH:30][c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[Cl:37]>O.Cl.[O-][N+](=O)c1ccccc1>[CH3:1][n:2]1[c:3]2[cH:4][cH:5][c:6]([cH:7][c:8]2[n:9][c:30]1-[c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[Cl:37])[CH2:10][N:11]1[CH2:12][CH2:13][N:14]([CH2:15][CH2:16]1)[CH:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1|EP3162802B1_0325
4.1.58|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H0&+0&D3:6](-[C&H3&D1:5])=O)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:4]:[c:3]:[c:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:6]:1-[C&H3&D1:5]|[CH3:1][C:2](=O)[C:3]([CH3:4])=O.[NH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1[NH2:12])[N+:13]([O-:14])=[O:15]>>[CH3:4][c:3]1[n:5][c:6]2[cH:7][cH:8][c:9]([cH:10][c:11]2[n:12][c:2]1[CH3:1])[N+:13]([O-:14])=[O:15]|US20200102303A1_0647
4.1.62|[C:9]-[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[c:6]:[c:5]-[C&H0&+0&D3:4](=[O&H0&D1:3])-[N&H1&+0&D2:2]-[C:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[c&H0&+0&D3:4](=[O&H0&D1:3]):[n&H0&+0&D3:2]:1-[C:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][C:5](=O)[NH:6][c:7]1[n:8][cH:9][cH:10][n:11][c:12]1[C:13](=[O:14])[NH:15][CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>CN(C)C=O.O=C(O[Na])O[Na]>[CH3:1][CH:2]([CH3:3])[CH2:4][c:5]1[n:6][c:7]2[n:8][cH:9][cH:10][n:11][c:12]2[c:13]([n:15]1[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)=[O:14]|EP3683222A1_3551
2.3.8|[C:8]-[N&H1&+0&D2:7]-[C:6]-[C:5]-[N&H1&+0&D2:4]-[O:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[C:8]-[N&H0&+0&D3:7]1-[C:6]-[C:5]-[N&H0&+0&D3:4](-[O:3])-[C&H0&+0&D3:1]-1=[O&H0&D1:2]|[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][CH:14]([CH2:15][CH2:16]1)[NH:17][C:18](=[O:19])[C@@H:20]1[CH2:21][CH2:22][C@H:23]([CH2:24][NH:25]1)[NH:26][O:27][CH2:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1.[O:35]=[C:36](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>Cc1ccc(cc1)S([O-])(=O)=O.CC(C)N(CC)C(C)C.O=P(O)(O)O.[O-]C(=O)O.ClCCl.[Na+]>[O:1]=[C:2]([O:3][CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:11]1[CH2:12][CH2:13][CH:14]([CH2:15][CH2:16]1)[NH:17][C:18](=[O:19])[C@@H:20]1[CH2:21][CH2:22][C@@H:23]2[CH2:24][N:25]1[C:36]([N:26]2[O:27][CH2:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1)=[O:35]|EP3670512A1_0122
4.1.67|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[O&H0&D1:4]=[C&H0&+0&D3:3](-[C&H0&+0&D3:2](=[O&H0&D1:1])-O)-O>>[n&H1&+0&D2:8]1:[c:7]:[c:6]:[n&H1&+0&D2:5]:[c&H0&+0&D3:3](=[O&H0&D1:4]):[c&H0&+0&D3:2]:1=[O&H0&D1:1]|O.O.[NH2:1][c:2]1[cH:3][c:4]([c:5]([cH:6][c:7]1[NH2:8])[Cl:9])[F:10].[O:11]=[C:12](O)[C:13](=[O:14])O>Cl>[O:11]=[c:12]1[nH:8][c:7]2[cH:6][c:5]([c:4]([cH:3][c:2]2[nH:1][c:13]1=[O:14])[F:10])[Cl:9]|US08673908B2_1337
4.1.111|[N&H2&+0&D1:8]-[C:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O)-O>>[N&H1&+0&D2:8]1-[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|[NH2:1][C:2]([NH2:3])=[O:4].[O-:5][N+:6](=[O:7])[CH:8]([C:9](=[O:10])O)[C:11](=[O:12])O>>[O-:5][N+:6](=[O:7])[CH:8]1[C:11]([NH:1][C:2]([NH:3][C:9]1=[O:10])=[O:4])=[O:12]|US06916807B2_0476
4.1.34|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C&H3&D1:5])=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[c&H0&+0&D3:6](-[C&H3&D1:5]):[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:1|[CH3:1][CH2:2][C:3]([CH3:4])=O.N[NH:5][c:6]1[cH:7][cH:8][cH:9][c:10]([n:11]1)[Br:12]>CCO.OCCOCCO>[CH3:1][c:2]1[c:7]2[cH:8][cH:9][c:10]([n:11][c:6]2[nH:5][c:3]1[CH3:4])[Br:12]|US20170166555A1_0257
1.2.3|[C&H3&D1:9]-[N&H0&+0&D3:8](-[c:7]:[c:6]-[N&H2&+0&D1:5])-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[s:1])=O>>[C&H3&D1:9]-[n&H0&+0&D3:8]1:[c:7]:[c:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[s:1]|[CH3:1][CH2:2][S:3][c:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[s:11][c:12]1[C:13](=O)[N:14]([CH3:15])[c:16]1[n:17][cH:18][c:19]([cH:20][c:21]1[NH2:22])[C:23]([F:24])([F:25])[F:26]>CCSc1c(sc2ccccc21)C(=O)Nc1cc(cnc1NC)C(F)(F)F.CCOC(C)=O.CC(=O)O>[CH3:1][CH2:2][S:3][c:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[s:11][c:12]1-[c:13]1[n:22][c:21]2[cH:20][c:19]([cH:18][n:17][c:16]2[n:14]1[CH3:15])[C:23]([F:24])([F:25])[F:26]|US10202380B2_0264
4.1.68|[N&H2&+0&D1:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-N.[N&H2&+0&D1:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[n&H1&+0&D2:8]1:[c&H0&+0&D3:7](:[n&H1&+0&D2:5]:[c:4]:[c:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1])=[O&H0&D1:6]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH2:8])[C:9](=[O:10])O.N[C:11]([NH2:12])=[O:13]>CCO.Oc1ccccc1>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:9]([nH:12][c:11]([nH:8][c:7]12)=[O:13])=[O:10]|US20200299277A1_1129
4.1.58|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[O&H1&D1:4]-[C&H0&+0&D3:3](-[C&H0&+0&D3:2](-[O&H1&D1:1])=O)=O>>[n&H0&+0&D2:8]1:[c:7]:[c:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:3](-[O&H1&D1:4]):[c&H0&+0&D3:2]:1-[O&H1&D1:1]|O.O.[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH2:8])[N+:9]([O-:10])=[O:11].O=[C:12]([OH:13])[C:14](=O)[OH:15]>Cl>[O-:10][N+:9](=[O:11])[c:5]1[cH:4][cH:3][c:2]2[n:1][c:14]([c:12]([n:8][c:7]2[cH:6]1)[OH:13])[OH:15]|US09073825B2_0195
4.1.16|[C&H3&D1:9]-[C&H0&+0&D3:8](=O)-O.[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=O)O.[CH3:3][c:4]1[n:5][c:6]([cH:7][c:8]([c:9]1[NH2:10])[NH:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[C:18]#[N:19])[CH3:20]>CC(=O)OC(C)=O>[CH3:20][c:6]1[cH:7][c:8]2[c:9]([n:10][c:2]([n:11]2-[c:12]2[cH:13][cH:14][c:15]([cH:16][cH:17]2)[C:18]#[N:19])[CH3:1])[c:4]([n:5]1)[CH3:3]|US20120172351A1_0876
4.1.67|[N&H2&+0&D1:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[O&H0&D1:4]=[C&H0&+0&D3:3](-[C&H0&+0&D3:2](=[O&H0&D1:1])-O)-O>>[n&H1&+0&D2:8]1:[c:7]:[c:6]:[n&H1&+0&D2:5]:[c&H0&+0&D3:2](=[O&H0&D1:1]):[c&H0&+0&D3:3]:1=[O&H0&D1:4]|[NH2:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[NH2:8])[C:9]([F:10])([F:11])[F:12])[Cl:13].[O:14]=[C:15](O)[C:16](=[O:17])O.O.O>[Na+].Cl.[OH-]>[O:14]=[c:15]1[nH:1][c:2]2[cH:3][c:4]([cH:5][c:6]([c:7]2[nH:8][c:16]1=[O:17])[C:9]([F:10])([F:11])[F:12])[Cl:13]|EP0832074B1_0059
4.1.7|[C&H3&D1:8]-[C&H1&+0&D2:7]=[C&H1&+0&D2:6]-[C&H1&+0&D2:5]=O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H1&+0&D2:5]:[c&H1&+0&D2:6]:1|[CH3:1][CH:2]=[CH:3][CH:4]=O.[NH2:5][c:6]1[cH:7][c:8]([cH:9][cH:10][c:11]1[I:12])[Br:13]>O.O.[O-][N+](=O)c1ccccc1.O=S(=O)(O)O.[OH-].[K+]>[CH3:1][c:2]1[cH:3][cH:4][c:7]2[c:8]([cH:9][cH:10][c:11]([c:6]2[n:5]1)[I:12])[Br:13]|US20200331900A1_0737
4.1.16|[C&H3&D1:9]-[N&H1&+0&D2:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-O)=O>>[C&H3&D1:9]-[n&H0&+0&D3:8]1:[c:7]:[c:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2]|O=[C:1](O)[c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[OH:8])[Cl:9].[CH3:10][NH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[NH2:18]>O=P12OP3(OP(O2)(OP(O1)(O3)=O)=O)=O>[CH3:10][n:11]1[c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[n:18][c:1]1-[c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[OH:8])[Cl:9]|EP3419969B1_0217
4.1.16|[C&H3&D1:9]-[N&H1&+0&D2:8]-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[n:2])-[C&H0&+0&D3:1](-O)=O>>[C&H3&D1:9]-[n&H0&+0&D3:8]1:[c:7]:[c:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[n:2]|[CH3:1][CH2:2][S:3](=[O:4])(=[O:5])[N:6]1[CH2:7][CH2:8][N:9]([CH2:10][CH2:11]1)[c:12]1[cH:13][n:14][c:15]([c:16]([n:17]1)[C:18](=O)O)[NH2:19].[CH3:20][NH:21][c:22]1[cH:23][cH:24][cH:25][cH:26][c:27]1[NH2:28]>CCOP(=O)(C#N)OCC.CCN(CC)CC.COCCOC>[CH3:1][CH2:2][S:3](=[O:4])(=[O:5])[N:6]1[CH2:7][CH2:8][N:9]([CH2:10][CH2:11]1)[c:12]1[cH:13][n:14][c:15]([c:16]([n:17]1)-[c:18]1[n:28][c:27]2[cH:26][cH:25][cH:24][cH:23][c:22]2[n:21]1[CH3:20])[NH2:19]|US10377754B2_0329
1.2.3|[C&H3&D1:9]-[N&H0&+0&D3:8](-[c:7]:[c:6]-[N&H2&+0&D1:5])-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])=O>>[C&H3&D1:9]-[n&H0&+0&D3:8]1:[c:7]:[c:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][n:2]1[c:3]([cH:4][c:5]([c:6]([c:7]1=[O:8])[N:9]([CH3:10])[C:11](=O)[c:12]1[n:13][cH:14][c:15]([cH:16][c:17]1[S:18][CH2:19][CH3:20])[Br:21])[NH2:22])[C:23]([F:24])([F:25])[F:26]>CCSc1cc(cnc1C(=O)Nc1cc(n(c(c1NC)=O)C)C(F)(F)F)Br.CC(=O)O.O>[CH3:10][n:9]1[c:11]([n:22][c:5]2[cH:4][c:3]([n:2]([c:7]([c:6]21)=[O:8])[CH3:1])[C:23]([F:24])([F:25])[F:26])-[c:12]1[n:13][cH:14][c:15]([cH:16][c:17]1[S:18][CH2:19][CH3:20])[Br:21]|US20200131177A1_0328
4.1.45|[N&H2&+0&D1:9]-[c:8]:[c:7]-[N&H1&+0&D2:6]-[c&H0&+0&D3:5](:[c:4]):[c:3].[O:2]-[C&H0&+0&D4:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:9]1:[c:8]:[c:7]:[n&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3]):[c&H0&+0&D3:1]:1-[O:2]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][c:11]1[cH:12][cH:13][c:14]([c:15]([cH:16]1)[NH:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[NH2:24].CO[C:25]([O:26][CH3:27])(OC)OC>CC(=O)O.O[Na]>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][c:11]1[cH:16][c:15]2[c:14]([cH:13][cH:12]1)[n:24][c:25]([n:17]2-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[O:26][CH3:27]|US20120172351A1_0744
4.1.30|[C:9]-[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[C:6])=O.[N&H2&+0&D1:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:5]:[c:4]:[c:3]:[c&H0&+0&D3:2](=[O&H0&D1:1]):[n&H0&+0&D3:7]:1-[C:6]|[NH2:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[C:8](=[O:9])O)[Cl:10])[Cl:11].O=[C:12]1[NH:13][CH:14]2[CH2:15][CH2:16][CH2:17][CH:18]1[CH2:19]2>Nc1c(cccc1C(=O)O)Cl.O=C1Nc2ccccc2C1=O.CCN(CC)CC.O=P(Cl)(Cl)Cl.[O-]C([O-])=O.ClC(Cl)Cl.OO.[K+].[K+]>[O:9]=[c:8]1[c:7]2[c:6]([cH:5][c:4]([cH:3][c:2]2[n:1][c:12]2[CH:18]3[CH2:17][CH2:16][CH2:15][CH:14]([CH2:19]3)[n:13]12)[Cl:11])[Cl:10]|EP1015434B1_0063
4.2.2|[C:7]-[C&H0&+0&D3:6](-[N&H2&+0&D1:5])=[N&H0&+0&D2:4]-O.[C:3]-[C&H0&+0&D3:2](=[O&H0&+0&D1:1])-O-C(=O)-C(-F)(-F)-F>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[c&H0&+0&D3:2](-[C:3]):[o&H0&+0&D2:1]:[n&H0&+0&D2:4]:1|[NH2:1][C:2]([CH2:3][N:4]1[C:5]([C:6]2([CH2:7][O:8][c:9]3[cH:10][c:11]4[O:12][CH2:13][O:14][c:15]4[cH:16][c:17]32)[c:18]2[cH:19][cH:20][cH:21][cH:22][c:23]21)=[O:24])=[N:25]O.[O:26]=[C:27](OC(=O)C(F)(F)F)[C:28]([F:29])([F:30])[F:31]>CC(C)N(CC)C(C)C.ClCCl>[O:24]=[C:5]1[N:4]([c:23]2[cH:22][cH:21][cH:20][cH:19][c:18]2[C:6]11[CH2:7][O:8][c:9]2[cH:10][c:11]3[O:12][CH2:13][O:14][c:15]3[cH:16][c:17]21)[CH2:3][c:2]1[n:1][c:27]([o:26][n:25]1)[C:28]([F:29])([F:30])[F:31]|US20120208852A1_0458
2.1.10|[N&H2&+0&D1:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-[N&H1&+0&D2:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[n&H1&+0&D2:8]1:[c&H0&+0&D3:2](=[O&H0&D1:1]):[c:3]:[c:4]:[n&H1&+0&D2:5]:[c&H0&+0&D3:7]:1=[O&H0&D1:6]|CO[C:1](=[O:2])[c:3]1[cH:4][cH:5][s:6][c:7]1[NH:8][C:9]([NH2:10])=[O:11]>>[O:2]=[c:1]1[nH:10][c:9]([nH:8][c:7]2[s:6][cH:5][cH:4][c:3]21)=[O:11]|US20130053407A1_0370
4.1.85|[C:9]-[C&H0&+0&D2:8]#[C&H0&+0&D2:7]-[C:6].[N&H2&+0&D1:5]-[n&H0&+&D3:4](:[c:3]):[c&H1&+0&D2:2]:[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:7]:1-[C:6]|[I-].[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]#[C:7][C:8]([CH3:9])([CH3:10])[OH:11].[NH2:12][n+:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>>[CH3:9][C:8]([CH3:10])([OH:11])[c:7]1[n:12][n:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[c:6]1[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20120178742A1_0275
4.1.12|[C&H3&D1:8]-[C&H1&+0&D3:7](-[C&H0&+0&D3:6](-[C&H3&D1:5])=O)-Br.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[C&H3&D1:5]|[CH3:1][C:2](=O)[CH:3]([CH3:4])Br.[NH2:5][c:6]1[cH:7][n:8][cH:9][cH:10][n:11]1>>[CH3:4][c:3]1[c:2]([n:5][c:6]2[cH:7][n:8][cH:9][cH:10][n:11]12)[CH3:1]|US20060148796A1_0145
4.1.54|[N&H2&+0&D1:8]-[c:7]:[c:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O-C.[N&H2&+0&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-N>>[n&H1&+0&D2:8]1:[c:7]:[c:6]:[c&H0&+0&D3:5](:[n&H1&+0&D2:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1])=[O&H0&D1:4]|[CH3:1][c:2]1[cH:3][s:4][c:5]([c:6]1[NH2:7])[C:8](=[O:9])OC.N[C:10]([NH2:11])=[O:12]>O.CN(C)C=O>[CH3:1][c:2]1[cH:3][s:4][c:5]2[c:8]([nH:11][c:10]([nH:7][c:6]12)=[O:12])=[O:9]|US20200046702A1_0358
4.1.49|[C:9]-[C&H2&+0&D2:8]-[C&H0&+0&D3:7](-[C:6])=O.[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H0&+0&D3:4](-[N&H2&+0&D1:5]):[c:3]:[c:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:7]:1-[C:6]|[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[NH2:9].O=[C:10]1[CH2:11][CH2:12][S:13][CH2:14]1>[Na+].CCC(C)=O.ClCCCl.Cl[Zn]Cl.[OH-]>[NH2:1][c:2]1[c:11]2[CH2:12][S:13][CH2:14][c:10]2[n:9][c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]12|US20110269790A1_0179
4.1.90|[N&H0&+0&D1:9]#[C&H0&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:8](:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[c:1])-[c&H0&+0&D3:7](:[c:6]):[c:5]|[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.[NH2:9][c:10]1[cH:11][c:12]([cH:13][cH:14][n:15]1)[Br:16]>O.Br[Cu].I[Zn]I.c1ccc2ccc3cccnc3c2n1>[Br:16][c:12]1[cH:13][cH:14][n:15]2[n:1][c:2]([n:9][c:10]2[cH:11]1)-[c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1|US09115130B2_0099
4.1.99|[C:8]-[N&H0&+0&D2:7]=[C&H0&+0&D2:6]=[S&H0&D1:5].[C:4]-[C&H0&+0&D3:3](-[N&H1&+0&D2:2]-[N&H2&+0&D1:1])=O>>[C:8]-[n&H0&+0&D3:7]1:[c&H0&+0&D3:6](:[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:3]:1-[C:4])=[S&H0&D1:5]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][CH2:10][C:11](=O)[NH:12][NH2:13].[CH3:14][O:15][CH2:16][CH2:17][CH2:18][N:19]=[C:20]=[S:21]>>[CH3:1][O:2][c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[O:9][CH2:10][c:11]1[n:12][nH:13][c:20]([n:19]1[CH2:18][CH2:17][CH2:16][O:15][CH3:14])=[S:21]|US20070093483A1_1036
4.3.14|[C:7]-[C&H0&+0&D3:6](=[N&H1&+0&D1:5])-[N&H2&+0&D1:4].[Cl&H0&D1:3]-[C&H0&+0&D4:2](-[S&H0&+0&D2:1]-Cl)(-Cl)-Cl>>[C:7]-[c&H0&+0&D3:6]1:[n&H0&+0&D2:5]:[s&H0&+0&D2:1]:[c&H0&+0&D3:2](-[Cl&H0&D1:3]):[n&H0&+0&D2:4]:1|[NH:1]=[C:2]([NH2:3])[C:4]([Cl:5])([Cl:6])[Cl:7].[Cl:8][C:9](Cl)(Cl)[S:10]Cl>>[Cl:5][C:4]([Cl:6])([Cl:7])[c:2]1[n:3][c:9]([s:10][n:1]1)[Cl:8]|US20190082687A1_0230
4.1.45|[N&H0&+0&D1:9]#[C&H0&+0&D2:8]-Br.[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[N&H2&+0&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[CH3:8])[NH:9][c:10]1[n:11][c:12]([cH:13][c:14]([c:15]1[NH2:16])[O:17][CH:18]([CH2:19][CH3:20])[CH2:21][CH3:22])[CH3:23])[CH3:24].[N:25]#[C:26]Br>CC#N>[CH3:22][CH2:21][CH:18]([CH2:19][CH3:20])[O:17][c:14]1[cH:13][c:12]([n:11][c:10]2[c:15]1[n:16][c:26]([n:9]2-[c:5]1[c:6]([cH:7][c:2]([cH:3][c:4]1[CH3:24])[CH3:1])[CH3:8])[NH2:25])[CH3:23]|US20190151295A1_1657
4.1.24|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[c:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|[NH4+].[CH3:1][c:2]1[c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[o:9][c:10]([c:11]1[C:12]#[N:13])=[O:14])[Cl:15].[N-:16]=[N+:17]=[N-:18]>CCO>[CH3:1][c:2]1[c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[o:9][c:10]([c:11]1-[c:12]1[n:13][n:18][n:17][nH:16]1)=[O:14])[Cl:15]|EP2357177A1_0133
1.2.14|[C&H3&D1:9]-[C&H1&+0&D3:8]1-[O&H0&+0&D2:7]-[C&H0&+0&D4:6]-1(-[C:5])-[c:4].[C:3]-[N&H1&+0&D2:2]-[C:1]>>[C&H3&D1:9]-[C@&H1&+0&D3:8](-[N&H0&+0&D3:2](-[C:3])-[C:1])-[C@@&H0&+0&D4:6](-[C:5])(-[c:4])-[O&H1&+0&D1:7]|[CH3:1][CH:2]1[O:3][C:4]1([CH2:5][n:6]1[cH:7][n:8][cH:9][n:10]1)[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[F:17])[F:18].[cH:19]1[cH:20][cH:21][n:22][c:23]([cH:24]1)[CH:25]1[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]1>O.O.O.CC#N.[O-][Cl](=O)(=O)=O.[Li+]>[CH3:1][C@@H:2]([N:28]1[CH2:27][CH2:26][CH:25]([CH2:30][CH2:29]1)[c:23]1[cH:24][cH:19][cH:20][cH:21][n:22]1)[C@:4]([OH:3])([CH2:5][n:6]1[cH:7][n:8][cH:9][n:10]1)[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[F:17])[F:18]|US08940768B2_0275
4.1.24|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[n:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[n:4]|[Na+].[N-:1]=[N+:2]=[N-:3].[N:4]#[C:5][c:6]1[cH:7][cH:8][c:9]2[cH:10][cH:11][c:12]3[cH:13][cH:14][cH:15][n:16][c:17]3[c:18]2[n:19]1>[NH4+].[Cl-].CN(C)C=O.Cl[Li]>[cH:15]1[cH:14][cH:13][c:12]2[cH:11][cH:10][c:9]3[cH:8][cH:7][c:6]([n:19][c:18]3[c:17]2[n:16]1)-[c:5]1[n:4][n:3][n:2][nH:1]1|US20170240511A1_0239
4.1.24|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[c:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[n&H0&+0&D2:8]1:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|[Na+].[CH3:1][c:2]1[cH:3][c:4]([n:5][c:6]([n:7]1)/[CH:8]=[CH:9]/[c:10]1[cH:11][cH:12][cH:13][c:14]([cH:15]1)[C:16]#[N:17])[N:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1.[N-:23]=[N+:24]=[N-:25]>[NH4+].[Cl-].CN(C)C=O>[CH3:1][c:2]1[cH:3][c:4]([n:5][c:6]([n:7]1)/[CH:8]=[CH:9]/[c:10]1[cH:11][cH:12][cH:13][c:14]([cH:15]1)-[c:16]1[n:23][n:24][nH:25][n:17]1)[N:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1|US20190284182A1_1127
2.5.5|[N&H0&+0&D1:9]#[C&H0&+0&D2:8]-[c:7]:[c&H0&+0&D3:6](:[n:5])-[c&H0&+0&D3:4](:[c:3]):[c:2]-[N&H2&+0&D1:1]>>[N&H2&+0&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:1]:[c:2]:[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:6](:[n:5]):[c:7]:1|[CH3:1][CH:2]([CH3:3])[CH2:4][n:5]1[c:6]([n:7][c:8]([c:9]1-[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[NH2:16])[C:17]#[N:18])[CH2:19][CH2:20][CH3:21]>CCO.CC(=O)Cl>[CH3:21][CH2:20][CH2:19][c:6]1[n:7][c:8]2[c:17]([n:16][c:15]3[cH:14][cH:13][cH:12][cH:11][c:10]3[c:9]2[n:5]1[CH2:4][CH:2]([CH3:1])[CH3:3])[NH2:18]|EP3134402B1_0135
4.1.69|[c:9]:[n&H0&+0&D2:8]:[c:7]-[N&H1&+0&D2:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[c:9]:[n&H0&+0&D3:8]1:[c:7]:[n&H0&+0&D2:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|O=[C:1]([NH:2][NH:3][c:4]1[cH:5][cH:6][c:7]([cH:8][n:9]1)[Br:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17]>O=P(Cl)(Cl)Cl>[Cl:17][c:16]1[cH:15][cH:14][cH:13][cH:12][c:11]1-[c:1]1[n:2][n:3][c:4]2[cH:5][cH:6][c:7]([cH:8][n:9]12)[Br:10]|US08207169B2_0464
4.1.84|[N&H2&+0&D1:7]-[N&H1&+0&D2:6]-[c:5]:[n&H0&+0&D2:4]:[c:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[n&H1&+0&D2:7]1:[n&H0&+0&D2:6]:[c:5]:[n&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:1]:1=[O&H0&D1:2]|[NH2:1][NH:2][c:3]1[cH:4][c:5]([n:6][cH:7][n:8]1)-[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15].[O:16]=[C:17](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>C1CCOC1>[O:16]=[c:17]1[nH:1][n:2][c:3]2[cH:4][c:5]([n:6][cH:7][n:8]12)-[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[Cl:15]|US20120225904A1_0158
4.1.113|[N&H1&+0&D1:8]=[C:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C)-O-C>>[N&H0&+0&D2:8]1=[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:4](=[O&H0&D1:5])-[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[O:9][CH:10]([C:11](=[O:12])OC)[C:13](=[O:14])OC.[NH:15]=[C:16]([NH2:17])[C:18]([F:19])([F:20])[F:21]>C[O-].CO.[Na+]>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[O:9][CH:10]1[C:13]([N:15]=[C:16]([NH:17][C:11]1=[O:12])[C:18]([F:19])([F:20])[F:21])=[O:14]|EP3515903B1_0215
4.3.3|[C:8]-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[C:5])=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[C:5])-[N&H2&D1:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7][C:8](=[O:9])[c:10]1[cH:11][n:12][cH:13][cH:14][cH:15]1.[NH2:16][C:17]([NH2:18])=[S:19]>O.O=C(O[K])O[K].O=S(=O)(Cl)Cl.ClCCl.C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:18][c:17]([s:19][c:7]1[C:8](=[O:9])[c:10]1[cH:15][cH:14][cH:13][n:12][cH:11]1)[NH2:16]|US20100227859A1_0598
4.3.9|[S&H0&+0&D1:9]=[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[c:6]:[c&H1&+0&D2:5]:[c:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[s&H0&+0&D2:9]1:[c&H0&+0&D3:5](:[c:4]):[c:6]:[n&H0&+0&D2:7]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([O:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[C:16](=[S:17])[NH:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:32]([F:33])([F:34])[F:35]>N#C[Fe-3](C#N)(C#N)(C#N)(C#N)C#N.CO.O[Na].O.[K+].[K+].[K+]>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([O:8][CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)-[c:16]1[n:18][c:19]2[cH:24][cH:23][c:22]([cH:21][c:20]2[s:17]1)[O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:32]([F:33])([F:34])[F:35]|EP1641453B1_0265
4.1.111|[N&H2&+0&D1:8]-[C:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C)-O-C>>[N&H1&+0&D2:8]1-[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:4](=[O&H0&D1:5])-[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|CO[C:1](=[O:2])[CH:3]([C:4](=[O:5])OC)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[O:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[NH2:19][C:20]([NH2:21])=[O:22]>Cl.CO[Na]>[O:22]=[C:20]1[NH:21][C:1]([CH:3]([C:4]([NH:19]1)=[O:5])[c:6]1[cH:11][cH:10][c:9]([cH:8][cH:7]1)[O:12][c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)=[O:2]|US10676475B2_0795
4.1.90|[N&H1&+0&D1:9]=[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[c:6]:[n&H0&+0&D2:5]:[c:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[n&H0&+0&D2:9]1:[n&H0&+0&D3:5](:[c:4]):[c:6]:[n&H0&+0&D2:7]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][n:5][cH:6][c:7]1[C:8](=[NH:9])[NH:10][c:11]1[cH:12][cH:13][c:14]([cH:15][n:16]1)[F:17]>O.Cc1ccccc1>[CH3:1][c:2]1[cH:3][cH:4][n:5][cH:6][c:7]1-[c:8]1[n:10][c:11]2[cH:12][cH:13][c:14]([cH:15][n:16]2[n:9]1)[F:17]|US09879009B2_0510
1.7.12|[Cl&H0&D1:8]-[C&H0&+0&D3:7](-[F&H0&D1:6])=[C&H0&+0&D3:5](-[F&H0&D1:4])-[F&H0&D1:3].[O&H1&+0&D1:2]-[c:1]>>[Cl&H0&D1:8]-[C&H1&+0&D3:7](-[F&H0&D1:6])-[C&H0&+0&D4:5](-[F&H0&D1:4])(-[F&H0&D1:3])-[O&H0&+0&D2:2]-[c:1]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[OH:11].[F:12][C:13]([Cl:14])=[C:15]([F:16])[F:17]>CC(C)=O.O[K]>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[O:11][C:15]([F:16])([F:17])[CH:13]([F:12])[Cl:14]|EP0337600A2_0045
4.1.29|[C&H3&+0&D1:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[C&H1&+0&D2:1]=O>>[c&H1&+0&D2:9]1:[c&H1&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[o:13]1)[C:14]([CH3:15])=O.[NH2:16][c:17]1[cH:18][c:19]([cH:20][cH:21][c:22]1[CH:23]=O)[Cl:24]>O.Cc1ccc(cc1)S(=O)(=O)O.ClC(Cl)Cl>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]2[cH:8][c:9]([cH:10][cH:11][c:12]2[o:13]1)-[c:14]1[cH:15][cH:23][c:22]2[cH:21][cH:20][c:19]([cH:18][c:17]2[n:16]1)[Cl:24]|US20060161001A1_0215
4.1.8|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C&H0&+0&D3:5](-[C:4])=O)=O.[C:3]-[N&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[c&H1&+0&D2:6]:[c&H0&+0&D3:5](-[C:4]):[n&H0&+0&D2:1]:[n&H0&+0&D3:2]:1-[C:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7][C:8]([CH3:9])=O.[NH2:10][NH:11][CH2:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>ClCCl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([n:11]([n:10]1)[CH2:12][CH2:13][c:14]1[cH:19][cH:18][cH:17][cH:16][cH:15]1)[CH3:9]|US20200087322A1_2929
4.2.22|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[O&H1&+0&D1:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](:[o&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1])-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[O:9][CH3:10].[O:11]=[CH:12][c:13]1[cH:14][cH:15][cH:16][c:17]([c:18]1[OH:19])I>CCOC(C)=O.c1ccncc1>[CH3:10][O:9][c:7]1[cH:6][cH:5][cH:4][c:3]([cH:8]1)-[c:2]1[cH:1][c:17]2[cH:16][cH:15][cH:14][c:13]([c:18]2[o:19]1)[CH:12]=[O:11]|US20200392097A1_0141
4.1.58|[N&H2&+0&D1:9]-[c:8]:[c:7]-[N&H2&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H1&+0&D2:1]=O)=O>>[n&H0&+0&D2:9]1:[c:8]:[c:7]:[n&H0&+0&D2:6]:[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[C:8](=O)[CH:9]=O.[NH2:10][c:11]1[n:12][cH:13][n:14][c:15]([c:16]1[NH2:17])[OH:18].O=S(=O)(O)O>O.[Na+].CC([O-])=O.CCO>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)-[c:8]1[cH:9][n:17][c:16]2[c:15]([n:14][cH:13][n:12][c:11]2[n:10]1)[OH:18]|US20100305133A1_0317
4.1.8|[C&H3&D1:8]-[N&H1&+0&D2:7]-[N&H2&+0&D1:6].[C:5]-[C&H0&+0&D3:4](-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[C:1])=O)=O>>[C&H3&D1:8]-[n&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:4](-[C:5]):[c&H1&+0&D2:3]:[c&H0&+0&D3:2]:1-[C:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7][C:8](=O)[CH2:9][CH3:10].[CH3:11][NH:12][NH2:13]>O.CC(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([n:12]([n:13]1)[CH3:11])[CH2:9][CH3:10]|US20200087322A1_2941
4.1.120|[Br&H1&+0&D0:8].[N&H0&+0&D1:7]#[C&H0&+0&D2:6]-[C&H2&+0&D2:5]-[c:4]:[c:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[Br&H0&+0&D1:8]-[c&H0&+0&D3:2]1:[n&H0&+0&D2:1]:[c&H0&+0&D3:6](-[N&H2&+0&D1:7]):[c&H1&+0&D2:5]:[c:4]:[c:3]:1|[BrH:1].[N:2]#[C:3][c:4]1[n:5][cH:6][cH:7][cH:8][c:9]1[CH2:10][C:11]#[N:12]>[Na+].Cc1ccccc1.[OH-]>[NH2:12][c:11]1[cH:10][c:9]2[cH:8][cH:7][cH:6][n:5][c:4]2[c:3]([n:2]1)[Br:1]|US20200181118A1_1146
4.2.16|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1])=O>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[o&H0&+0&D2:1]:[c&H0&+0&D3:3](-[C:2]):[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([NH:7][C:8](=[O:9])[CH:10]=[CH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[C:18]([CH3:19])=O>O=P(Cl)(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][c:8]([o:9][c:18]1[CH3:19])[CH:10]=[CH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US10435398B2_0295
4.1.76|[N&H2&+0&D1:9]-[N&H1&+0&D2:8]-[c:7]:[n&H0&+0&D2:6]:[c:5].[c:4]:[c&H0&+0&D3:3](:[n:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:1](:[n&H0&+0&D3:6](:[c:5]):[c:7]:[n&H0&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:4]):[n:2]|[NH2:1][NH:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[n:12]1)[I:13].O=[CH:14][c:15]1[cH:16][cH:17][cH:18][cH:19][n:20]1>CC(=O)O[I](OC(C)=O)c1ccccc1.ClCCl>[I:13][c:8]1[cH:9][cH:10][c:11]2[c:6]([cH:7]1)[cH:5][cH:4][c:3]1[n:2][n:1][c:14]([n:12]12)-[c:15]1[cH:16][cH:17][cH:18][cH:19][n:20]1|US08889704B2_1078
4.1.71|[N&H1&+0&D1:8]=[C&H0&+0&D3:7](-[N&H2&+0&D1:6])-[N&H2&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-F>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:7](:[n&H0&+0&D2:6]:[c&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:3]:1:[c:4])-[N&H2&D1:5]|[NH:1]=[C:2]([NH2:3])[NH2:4].O=[CH:5][c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1F)[Br:12]>O.CN(C)C=O>[NH2:3][c:2]1[n:4][cH:5][c:6]2[cH:7][cH:8][c:9]([cH:10][c:11]2[n:1]1)[Br:12]|US20200172516A1_0276
1.3.6|[c:9]:[c&H0&+0&D3:8](:[c:7]-[C&H1&+0&D2:6]=[N&H0&+0&D2:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1])-Br>>[c:9]:[c&H0&+0&D3:8]1:[n&H0&+0&D3:4](:[n&H0&+0&D2:5]:[c&H1&+0&D2:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[Br:8])[CH:9]=[N:10][NH:11][c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18](=[O:19])[OH:20])Br>C[Si](C)(C)[N-][Si](C)(C)C.CN(C)C=O.[Li+]>[CH3:1][c:2]1[cH:3][c:4]2[c:5]([cH:9][n:10][n:11]2-[c:12]2[cH:13][cH:14][cH:15][c:16]([cH:17]2)[C:18](=[O:19])[OH:20])[c:6]([cH:7]1)[Br:8]|US08063065B2_0423
4.1.45|[C&H3&D1:9]-[N&H1&+0&D2:8]-[c:7]:[c:6]-[N&H0&+&D3:5](-[O&-])=O.[c:4]:[c&H0&+0&D3:3](:[n:2])-[C&H1&+0&D2:1]=O>>[C&H3&D1:9]-[n&H0&+0&D3:8]1:[c&H0&+0&D3:1](:[n&H0&+0&D2:5]:[c:6]:[c:7]:1)-[c&H0&+0&D3:3](:[c:4]):[n:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C@@H:9]1[CH2:10][CH2:11][CH2:12][N:13]([CH2:14]1)[C:15](=[O:16])[c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[N+:23]([O-])=O)[NH:24][CH3:25].[CH3:26][CH2:27][n:28]1[c:29]2[cH:30][n:31][cH:32][cH:33][c:34]2[cH:35][c:36]1[CH:37]=O>O=S(=O)(O[Na])O[Na].[O-]S(=O)S([O-])=O.CCO.ClCCl.O.[Na+].[Na+]>[CH3:26][CH2:27][n:28]1[c:29]2[cH:30][n:31][cH:32][cH:33][c:34]2[cH:35][c:36]1-[c:37]1[n:23][c:21]2[cH:22][c:17]([cH:18][cH:19][c:20]2[n:24]1[CH3:25])[C:15](=[O:16])[N:13]1[CH2:14][C@@H:9]([CH2:10][CH2:11][CH2:12]1)[NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20200407370A1_0629
1.2.14|[C&H3&D1:9]-[C@@&H1&+0&D3:8]1-[O&H0&+0&D2:7]-[C@@&H0&+0&D4:6]-1(-[C:5])-[c:4].[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:9]-[C@@&H1&+0&D3:8](-[n&H0&+0&D3:2](:[c:3]):[n:1])-[C@&H0&+0&D4:6](-[C:5])(-[c:4])-[O&H1&+0&D1:7]|[CH3:1][C@@H:2]1[O:3][C@@:4]1([CH2:5][n:6]1[cH:7][n:8][cH:9][n:10]1)[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[F:17].[cH:18]1[n:19][cH:20][nH:21][n:22]1>CCOC(C)=O.CN(C)C=O.O=C(O[Li])O[Li]>[CH3:1][C@@H:2]([n:21]1[cH:20][n:19][cH:18][n:22]1)[C@:4]([OH:3])([CH2:5][n:6]1[cH:7][n:8][cH:9][n:10]1)[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[F:17]|EP0659751A1_0110
1.2.14|[C&H3&D1:9]-[C@@&H1&+0&D3:8]1-[O&H0&+0&D2:7]-[C@@&H0&+0&D4:6]-1(-[C:5])-[c:4].[c:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:9]-[C@@&H1&+0&D3:8](-[n&H0&+0&D3:2](:[c:3]):[c:1])-[C@&H0&+0&D4:6](-[C:5])(-[c:4])-[O&H1&+0&D1:7]|[CH3:1][C@@H:2]1[O:3][C@@:4]1([CH2:5][n:6]1[cH:7][n:8][cH:9][n:10]1)[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[F:17].[O:18]=[c:19]1[nH:20][cH:21][cH:22][n:23]1-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[O:30][C:31]([F:32])([F:33])[CH:34]([F:35])[F:36]>CCOC(C)=O.CN(C)C=O.O=C(O[Cs])O[Cs]>[CH3:1][C@@H:2]([n:20]1[cH:21][cH:22][n:23]([c:19]1=[O:18])-[c:24]1[cH:29][cH:28][c:27]([cH:26][cH:25]1)[O:30][C:31]([F:32])([F:33])[CH:34]([F:35])[F:36])[C@:4]([OH:3])([CH2:5][n:6]1[cH:7][n:8][cH:9][n:10]1)[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[F:17]|EP0659751A1_0113
4.2.11|[O&H1&+0&D1:9]-[N&H0&+0&D2:8]=[C&H0&+0&D3:7](-[c:6]:[c&H0&+0&D3:5](:[c:4])-F)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[o&H0&+0&D2:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:7](:[c:6]:[c&H0&+0&D3:5]:1:[c:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[OH:1][N:2]=[C:3]([c:4]1[cH:5][cH:6][n:7][cH:8][cH:9]1)[c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1F)[F:16]>O.[Na+].C1CCOC1.[H-]>[F:16][c:13]1[cH:12][cH:11][c:10]2[c:3]([n:2][o:1][c:15]2[cH:14]1)-[c:4]1[cH:5][cH:6][n:7][cH:8][cH:9]1|US08969586B2_0641
4.1.113|[N&H1&+0&D1:8]=[C:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C-C)-O-C-C>>[N&H0&+0&D2:8]1=[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|CCO[C:1](=[O:2])[CH2:3][C:4](=[O:5])OCC.[NH:6]=[C:7]([NH2:8])[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1>CCO.[Na]>[O:5]=[C:4]1[CH2:3][C:1]([NH:8][C:7](=[N:6]1)[c:9]1[cH:14][cH:13][cH:12][cH:11][cH:10]1)=[O:2]|US20070167421A1_0369
4.1.34|[C&H3&+0&D1:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[OH:9].N[NH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>Cl.Cl[Zn]Cl>[OH:9][c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)-[c:2]1[cH:1][c:12]2[cH:13][cH:14][cH:15][cH:16][c:11]2[nH:10]1|EP0223937A1_0084
4.1.26|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[C:5])=O)=O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6](-[C:5]):[c&H1&+0&D2:7]:1|O=[C:1]([CH2:2][C:3](=O)[C:4]([F:5])([F:6])[F:7])[C:8]([F:9])([F:10])[F:11].[NH2:12][c:13]1[cH:14][cH:15][cH:16][c:17]([n:18]1)[NH2:19]>O=P(O)(O)O.[NH4+].O.[OH-]>[NH2:19][c:17]1[cH:16][cH:15][c:14]2[c:13]([n:18]1)[n:12][c:1]([cH:2][c:3]2[C:4]([F:5])([F:6])[F:7])[C:8]([F:9])([F:10])[F:11]|US20140249143A1_0826
4.2.16|[C&H3&D1:8]-[C&H0&+0&D3:7](=[O&H0&+0&D1:6])-[N&H1&+0&D2:5]-[C&H1&+0&D3:4](-[C:3])-[C&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[o&H0&+0&D2:6]:[c&H0&+0&D3:2](-[C:1]):[c&H0&+0&D3:4](-[C:3]):[n&H0&+0&D2:5]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([NH:7][C:8]([CH3:9])=[O:10])[C:11](=O)[CH2:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1>O=S(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][c:8]([o:10][c:11]1[CH2:12][CH2:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[CH3:9]|US20120238599A1_0215
4.2.3|[C:8]-[C&H0&+0&D3:7](=[O&H0&+0&D1:6])-[N&H1&+0&D2:5]-[N&H2&+0&D1:4].[c:3]-[N&H0&+0&D2:2]=[C&H0&+0&D2:1]=S>>[C:8]-[c&H0&+0&D3:7]1:[o&H0&+0&D2:6]:[c&H0&+0&D3:1](:[n&H0&+0&D2:4]:[n&H0&+0&D2:5]:1)-[N&H1&+0&D2:2]-[c:3]|[NH2:1][NH:2][C:3](=[O:4])[CH2:5][CH2:6][C:7](=[O:8])[NH:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[CH2:16][c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[Cl:23])[Cl:24].S=[C:25]=[N:26][c:27]1[cH:28][cH:29][cH:30][cH:31][c:32]1[Cl:33]>CN(C)C=O>[O:8]=[C:7]([CH2:6][CH2:5][c:3]1[n:2][n:1][c:25]([o:4]1)[NH:26][c:27]1[cH:28][cH:29][cH:30][cH:31][c:32]1[Cl:33])[NH:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:14][CH2:15]1)[CH2:16][c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[Cl:23])[Cl:24]|US08084478B2_0194
4.1.13|[N&H2&+0&D1:9]-[N&H1&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[c:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-F>>[n&H0&+0&D2:9]1:[c&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:3](:[c:4]):[n&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][O:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[Cl:9])F)[CH:10]=O.[NH2:11][NH:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[F:19]>CN1CCCC1.O=C(O[Cs])O[Cs]>[CH3:1][O:2][c:3]1[cH:4][c:5]2[cH:10][n:11][n:12]([c:6]2[cH:7][c:8]1[Cl:9])-[c:13]1[cH:18][cH:17][c:16]([cH:15][cH:14]1)[F:19]|US20090124607A1_0377
4.1.13|[N&H2&+0&D1:9]-[N&H1&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[n:4]:[c&H0&+0&D3:3](:[c:2]-[C&H1&+0&D2:1]=O)-F>>[n&H0&+0&D2:9]1:[c&H1&+0&D2:1]:[c:2]:[c&H0&+0&D3:3](:[n:4]):[n&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[NH:11][NH2:12].O=[CH:13][c:14]1[c:15]([cH:16][cH:17][n:18][c:19]1F)[I:20]>CN1CCCC1=O>[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)-[n:11]1[n:12][cH:13][c:14]2[c:15]([cH:16][cH:17][n:18][c:19]21)[I:20]|EP2593453B1_0233
4.1.14|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[C:3])=O)=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D3:1](-[C:2]):[c&H0&+0&D3:4](-[C:3]):[c&H1&+0&D2:5]:[c&H1&+0&D2:6]:1|[CH3:1][C:2](=O)[CH2:3][CH2:4][C:5](=O)[CH2:6][N:7]1[C:8]([c:9]2[cH:10][cH:11][cH:12][cH:13][c:14]2[C:15]1=[O:16])=[O:17].[CH3:18][O:19][c:20]1[cH:21][c:22]([cH:23][cH:24][c:25]1[O:26][CH3:27])[CH2:28][CH2:29][NH2:30]>CC(=O)O>[CH3:27][O:26][c:25]1[cH:24][cH:23][c:22]([cH:21][c:20]1[O:19][CH3:18])[CH2:28][CH2:29][n:30]1[c:2]([cH:3][cH:4][c:5]1[CH2:6][N:7]1[C:15]([c:14]2[cH:13][cH:12][cH:11][cH:10][c:9]2[C:8]1=[O:17])=[O:16])[CH3:1]|EP1284260A1_0676
4.3.11|[C:8]-[C&H1&+0&D3:7](-[C&H0&+0&D3:6](=[O&H0&D1:5])-O)-N.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:8]-[C&H1&+0&D3:7]1-[S&H0&+0&D2:1]-[C&H0&+0&D3:3](=[N&H0&+0&D2:4]-[C&H0&+0&D3:6]-1=[O&H0&D1:5])-[N:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[CH:5](N)[C:6](=[O:7])O.[NH2:8][C:9](=[S:10])[NH:11][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1>>[CH3:1][C:2]([CH3:3])([CH3:4])[CH:5]1[S:10][C:9](=[N:8][C:6]1=[O:7])[NH:11][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1|US07253196B2_0644
4.2.11|[O&H1&+0&D1:9]-[N&H0&+0&D2:8]=[C&H0&+0&D3:7](-[c:6]:[c&H0&+0&D3:5](:[c:4])-O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[o&H0&+0&D2:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:7](:[c:6]:[c&H0&+0&D3:5]:1:[c:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[C:9](=[N:10][OH:11])[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18])O>CC(=O)OC(C)=O>[CH3:1][CH2:2][c:3]1[cH:4][cH:5][c:6]2[o:11][n:10][c:9]([c:7]2[cH:8]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18]|US20150246902A1_0277
4.2.16|[O&H0&+0&D1:9]=[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[c:6]:[c&H0&+0&D3:5](:[n:4])-Cl)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[o&H0&+0&D2:9]1:[c&H0&+0&D3:8](:[n&H0&+0&D2:7]:[c:6]:[c&H0&+0&D3:5]:1:[n:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][cH:7][n:8][c:9]1Cl)[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1>C[Si](C)(C)OP(=O)=O>[cH:13]1[cH:14][cH:15][c:10]([cH:11][cH:12]1)-[c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][n:8][c:9]2[o:1]1|US10479802B2_1093
4.3.3|[C:8]-[C&H1&+0&D3:7](-[C&H0&+0&D3:6](-[C:5])=O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H0&+0&D3:6]:1-[C:5])-[N&H2&D1:2]|[CH3:1][CH:2]1[CH2:3][CH2:4][C:5]([CH:6]([CH2:7]1)Br)=O.[NH2:8][C:9]([NH2:10])=[S:11]>CCO>[CH3:1][CH:2]1[CH2:3][CH2:4][c:5]2[n:10][c:9]([s:11][c:6]2[CH2:7]1)[NH2:8]|US20190367452A1_1908
4.1.12|[N&H2&+0&D1:9]-[c:8]:[n&H0&+0&D2:7]:[c:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c:8]:[n&H0&+0&D3:7](:[c:6]):[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=O)[CH2:10]Br.[NH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][n:17]1>O.CCO.O=C(O)O[Na]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][n:17]2[cH:16][cH:15][cH:14][cH:13][c:12]2[n:11]1|US09695180B2_0358
4.1.12|[N&H2&+0&D1:9]-[c:8]:[n&H0&+0&D2:7]:[c:6].[c:5]:[c&H0&+0&D3:4](:[n:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c:8]:[n&H0&+0&D3:7](:[c:6]):[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[n:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[n:9][c:10]([c:11]2[cH:12][c:13]([cH:14][cH:15][c:16]21)[N+:17]([O-:18])=[O:19])[C:20](=O)[CH2:21]Br.[NH2:22][c:23]1[cH:24][cH:25][cH:26][cH:27][n:28]1>O.O=C(O)O[Na].OCC1CCCO1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[n:8]1[n:9][c:10]([c:11]2[cH:12][c:13]([cH:14][cH:15][c:16]21)[N+:17]([O-:18])=[O:19])-[c:20]1[cH:21][n:28]2[cH:27][cH:26][cH:25][cH:24][c:23]2[n:22]1|US20170190689A1_0548
4.3.11|[C:8]-[C&H1&+0&D3:7](-[C&H0&+0&D3:6](=[O&H0&D1:5])-O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:8]-[C&H1&+0&D3:7]1-[S&H0&+0&D2:1]-[C&H0&+0&D3:3](=[N&H0&+0&D2:4]-[C&H0&+0&D3:6]-1=[O&H0&D1:5])-[N:2]|[CH3:1][CH2:2][CH:3](Br)[C:4](=[O:5])O.[NH2:6][C:7](=[S:8])[NH:9][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1>>[CH3:1][CH2:2][CH:3]1[S:8][C:7](=[N:6][C:4]1=[O:5])[NH:9][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1|US07253196B2_0713
2.1.21|[C&H3&D1:8]-[C&H0&+0&D4:7](-[C&H3&D1:6])(-[C&H3&D1:5])-[O&H1&+0&D1:4].[C:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1]>>[C&H3&D1:8]-[C&H0&+0&D4:7](-[C&H3&D1:6])(-[C&H3&D1:5])-[N&H1&+0&D2:1]-[C&H0&+0&D3:2](-[C:3])=[O&H0&+0&D1:4]|[N:1]#[C:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:11][C:12]([CH3:13])([CH3:14])[OH:15]>O=S(=O)(O)O.ClCCl.O>[CH3:11][C:12]([CH3:13])([CH3:14])[NH:1][C:2](=[O:15])[C:3](=[O:4])[c:5]1[cH:10][cH:9][cH:8][cH:7][cH:6]1|US20090270394A1_0141
4.3.3|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-Cl)=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N:2]):[s&H0&+0&D2:1]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][NH:2][C:3]([NH2:4])=[S:5].[CH3:6][CH2:7][O:8][C:9](=[O:10])[CH:11](Cl)[C:12]([CH3:13])=O>ClCCCl>[CH3:6][CH2:7][O:8][C:9](=[O:10])[c:11]1[s:5][c:3]([n:4][c:12]1[CH3:13])[NH:2][CH3:1]|EP1622897B1_0088
4.3.3|[C:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-Cl)=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N&H2&D1:2]):[s&H0&+0&D2:1]:[c&H0&+0&D3:6]:1-[C:5]|[NH2:1][C:2]([NH2:3])=[S:4].O=[C:5]1[CH2:6][CH2:7][CH2:8][CH2:9][CH:10]1Cl>O.Cl>[NH2:1][c:2]1[n:3][c:5]2[CH2:6][CH2:7][CH2:8][CH2:9][c:10]2[s:4]1|US20200048242A1_1019
4.1.64|[N&H2&+0&D1:9]-[c:8]:[c&H1&+0&D2:7]:[c:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H1&+0&D2:9]1:[c:8]:[c&H0&+0&D3:7](:[c:6]):[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[c:3]|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[O:8][C:9]([F:10])([F:11])[F:12].[CH3:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[C:20](=O)[CH2:21]Br>CCN(CC)c1ccccc1.Cc1ccccc1C.CCOC(C)=O>[CH3:13][c:14]1[cH:19][cH:18][c:17]([cH:16][cH:15]1)-[c:20]1[cH:21][c:7]2[cH:6][c:5]([cH:4][cH:3][c:2]2[nH:1]1)[O:8][C:9]([F:10])([F:11])[F:12]|US20190359616A1_0205
4.1.12|[N&H2&+0&D1:9]-[c:8]:[n&H0&+0&D2:7]:[c:6].[c:5]:[c&H0&+0&D3:4](:[s:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c:8]:[n&H0&+0&D3:7](:[c:6]):[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[s:3]|Br.[CH3:1][c:2]1[cH:3][cH:4][cH:5][n:6][c:7]1[NH2:8].[CH3:9][c:10]1[n:11][c:12]([s:13][c:14]1[C:15](=O)[CH2:16]Br)[NH2:17]>CC(=O)N(C)C>[CH3:9][c:10]1[n:11][c:12]([s:13][c:14]1-[c:15]1[cH:16][n:6]2[cH:5][cH:4][cH:3][c:2]([c:7]2[n:8]1)[CH3:1])[NH2:17]|EP2218464A1_0087
2.1.21|[C&H3&D1:8]-[C&H0&+0&D4:7](-[C&H3&D1:6])(-[C&H3&D1:5])-[O&H1&+0&D1:4].[N&H0&+0&D1:3]#[C&H0&+0&D2:2]-[c:1]>>[C&H3&D1:8]-[C&H0&+0&D4:7](-[C&H3&D1:6])(-[C&H3&D1:5])-[N&H1&+0&D2:3]-[C&H0&+0&D3:2](=[O&H0&+0&D1:4])-[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][n:6][c:7]1[C:8]#[N:9].[CH3:10][C:11]([CH3:12])([CH3:13])[OH:14]>Cc1ccccc1.O=S(=O)(O)O.N.O>[CH3:10][C:11]([CH3:12])([CH3:13])[NH:9][C:8](=[O:14])[c:7]1[n:6][cH:5][cH:4][cH:3][c:2]1[CH3:1]|US20080293696A1_0654
4.2.16|[O&H0&+0&D1:9]=[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[c:6]:[c&H0&+0&D3:5](:[c:4])-Cl)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[o&H0&+0&D2:9]1:[c&H0&+0&D3:8](:[n&H0&+0&D2:7]:[c:6]:[c&H0&+0&D3:5]:1:[c:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[c:4]([cH:5][c:6]([cH:7][c:8]1[CH3:9])[C:10](=[O:11])[NH:12][c:13]1[cH:14][n:15][c:16]([cH:17][c:18]1Cl)[Cl:19])[CH3:20]>Cl.O=C(O[Cs])O[Cs].I[Cu].c1ccc2ccc3cccnc3c2n1.C1CCOC1>[CH3:1][O:2][c:3]1[c:4]([cH:5][c:6]([cH:7][c:8]1[CH3:9])-[c:10]1[n:12][c:13]2[cH:14][n:15][c:16]([cH:17][c:18]2[o:11]1)[Cl:19])[CH3:20]|EP2729472B1_0065
4.2.16|[O&H0&+0&D1:9]=[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[c:6]:[c&H0&+0&D3:5](:[c:4])-Br)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[o&H0&+0&D2:9]1:[c&H0&+0&D3:8](:[n&H0&+0&D2:7]:[c:6]:[c&H0&+0&D3:5]:1:[c:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1Br)[c:10]1[cH:11][n:12][cH:13][c:14]([cH:15]1)[Br:16]>O=C(O[Cs])O[Cs].C1COCCO1.I[Cu]>[Br:16][c:14]1[cH:13][n:12][cH:11][c:10]([cH:15]1)-[c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[o:1]1|EP3091005B1_0199
4.2.11|[O&H1&+0&D1:9]-[N&H0&+0&D2:8]=[C&H0&+0&D3:7](-[c:6]:[c&H0&+0&D3:5](:[c:4])-Cl)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[o&H0&+0&D2:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:7](:[c:6]:[c&H0&+0&D3:5]:1:[c:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[O:1]=[C:2]([OH:3])[CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([c:10]([c:11]1[Cl:12])Cl)[C:13](=[N:14][OH:15])[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22]>c1ccccc1.CN(C)C=O.Cl.[NaH]>[O:1]=[C:2]([OH:3])[CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]2[c:13]([n:14][o:15][c:10]2[c:11]1[Cl:12])-[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[F:22]|EP0205872A1_0040
4.1.12|[N&H2&+0&D1:9]-[c:8]:[n&H0&+0&D2:7]:[c:6].[c:5]:[c&H0&+0&D3:4](:[o:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c:8]:[n&H0&+0&D3:7](:[c:6]):[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[o:3]|[N:1]#[C:2][c:3]1[cH:4][n:5][c:6]([cH:7][cH:8]1)[NH2:9].O=[C:10]([CH2:11]Br)[c:12]1[cH:13][cH:14][c:15]([o:16]1)[Br:17]>>[N:1]#[C:2][c:3]1[cH:8][cH:7][c:6]2[n:9][c:10]([cH:11][n:5]2[cH:4]1)-[c:12]1[cH:13][cH:14][c:15]([o:16]1)[Br:17]|US20170283439A1_0353
4.3.3|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-Cl)=O.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[S&H0&+0&D1:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[s&H0&+0&D2:1]:[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Cl)[C:7]([CH3:8])=O.[CH3:9][O:10][CH2:11][C:12]([NH2:13])=[S:14]>CCOC(C)=O.c1ccccc1.O>[CH3:8][c:7]1[n:13][c:12]([s:14][c:6]1[C:4](=[O:5])[O:3][CH2:2][CH3:1])[CH2:11][O:10][CH3:9]|US20120129842A1_0469
4.1.12|[N&H2&+0&D1:9]-[c:8]:[n&H0&+0&D2:7]:[n:6].[c:5]:[c&H0&+0&D3:4](:[o:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c:8]:[n&H0&+0&D3:7](:[n:6]):[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[o:3]|O=[C:1]([CH2:2]Br)[c:3]1[cH:4][cH:5][cH:6][o:7]1.[NH2:8][c:9]1[cH:10][cH:11][c:12]([n:13][n:14]1)[Cl:15]>C1COCCO1.CC(C)O.ClC(Cl)Cl.O>[Cl:15][c:12]1[cH:11][cH:10][c:9]2[n:8][c:1]([cH:2][n:14]2[n:13]1)-[c:3]1[cH:4][cH:5][cH:6][o:7]1|US10822343B2_2202
4.1.12|[N&H2&+0&D1:9]-[c:8]:[n&H0&+0&D2:7]:[n:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c:8]:[n&H0&+0&D3:7](:[n:6]):[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[c:3]|[NH2:1][c:2]1[n:3][n:4][c:5]([s:6]1)-[c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[Cl:13].O=[C:14]([CH2:15]Br)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>CN(C)C=O.NC(=S)NN.O=C(Cl)c1ccccc1Cl>[Cl:13][c:12]1[cH:11][cH:10][cH:9][cH:8][c:7]1-[c:5]1[n:4][n:3]2[cH:15][c:14]([n:1][c:2]2[s:6]1)-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20190119300A1_0247
4.1.12|[N&H2&+0&D1:9]-[c:8]:[n&H0&+0&D2:7]:[c:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Cl)=O>>[n&H0&+0&D2:9]1:[c:8]:[n&H0&+0&D3:7](:[c:6]):[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[C:13](=O)[CH2:14]Cl.[NH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][n:21]1>CCOCC.CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][n:21]2[cH:20][cH:19][cH:18][cH:17][c:16]2[n:15]1|EP2376490B1_0268
4.1.24|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[c:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#11]>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|[N-:1]=[N+:2]=[N:3][Na].[N:4]#[C:5][c:6]1[cH:7][cH:8][c:9]2[C:10]([c:11]3[cH:12][cH:13][c:14]([cH:15][c:16]3[C:17]([c:18]2[cH:19]1)=[O:20])[N:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1)=[O:27]>[NH4+].[Cl-]>[O:27]=[C:10]1[c:11]2[cH:12][cH:13][c:14]([cH:15][c:16]2[C:17]([c:18]2[cH:19][c:6]([cH:7][cH:8][c:9]12)-[c:5]1[n:4][n:1][n:2][nH:3]1)=[O:20])[N:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1|US07858646B2_0276
4.1.24|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[o:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#11]>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[o:4]|[CH3:1][c:2]1[cH:3][c:4]2[o:5][c:6]([cH:7][c:8]([c:9]2[c:10]([c:11]1[Cl:12])[CH3:13])=[O:14])[C:15]#[N:16].[N-:17]=[N+:18]=[N:19][Na]>[NH4+].[Cl-].CN(C)C=O>[CH3:13][c:10]1[c:11]([c:2]([cH:3][c:4]2[o:5][c:6]([cH:7][c:8]([c:9]12)=[O:14])-[c:15]1[n:16][n:17][n:18][nH:19]1)[CH3:1])[Cl:12]|US20100249192A1_0240
4.1.62|[C&H3&D1:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-[c:5]:[c:4]-[N&H1&+0&D2:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:9]-[n&H0&+0&D3:8]1:[c&H0&+0&D3:2](-[C:1]):[n&H0&+0&D2:3]:[c:4]:[c:5]:[c&H0&+0&D3:7]:1=[O&H0&D1:6]|[CH3:1][NH:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[NH:11][C:12](=O)[CH:13]1[CH2:14][CH2:15][N:16]1[C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[Br:24]>C1COCCO1.O[Na]>[CH3:21][C:20]([CH3:22])([CH3:23])[O:19][C:17](=[O:18])[N:16]1[CH2:15][CH2:14][CH:13]1[c:12]1[n:11][c:10]2[cH:9][c:8]([cH:7][cH:6][c:5]2[c:3]([n:2]1[CH3:1])=[O:4])[Br:24]|EP3683222A1_3200
4.1.8|[C:9]-[C&H0&+0&D3:8](-[C&H1&+0&D3:7](-[C:6])-[C&H0&+0&D3:5](-[C:4])=O)=O.[C:3]-[N&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D3:2](-[C:3]):[n&H0&+0&D2:1]:[c&H0&+0&D3:5](-[C:4]):[c&H0&+0&D3:7]:1-[C:6]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([c:7]([cH:8]1)[Cl:9])[O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([C:18](=O)[CH2:19][CH3:20])[C:21](=O)[CH2:22][CH3:23].[CH3:24][CH2:25][O:26][C:27](=[O:28])[CH2:29][NH:30][NH2:31].Cl>CCN(CC)CC.CCO>[CH3:24][CH2:25][O:26][C:27](=[O:28])[CH2:29][n:30]1[n:31][c:21]([c:17]([c:18]1[CH2:19][CH3:20])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][O:10][c:6]1[cH:5][cH:4][c:3]([cH:8][c:7]1[Cl:9])[O:2][CH3:1])[CH2:22][CH3:23]|US20200323869A1_0355
4.1.24|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[s:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#11]>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[s:4]|[CH3:1][c:2]1[c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[s:9][c:10]1[C:11]#[N:12])[O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[O:21][CH2:22][c:23]1[cH:24][cH:25][c:26]2[cH:27][cH:28][cH:29][cH:30][c:31]2[n:32]1.[N-:33]=[N+:34]=[N:35][Na]>[NH4+].O.O.[Na+].[Cl-].CN(C)C=O.[OH-]>[CH3:1][c:2]1[c:3]2[cH:4][c:5]([cH:6][cH:7][c:8]2[s:9][c:10]1-[c:11]1[n:12][n:33][n:34][nH:35]1)[O:13][CH2:14][c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[O:21][CH2:22][c:23]1[cH:24][cH:25][c:26]2[cH:27][cH:28][cH:29][cH:30][c:31]2[n:32]1|US07521473B2_2256
3.11.3|[C&H2&+0&D1:8]=[C&H1&+0&D2:7]-[C:6].[C&H1&+0&D2:5]1=[C&H1&+0&D2:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]-1>>[C&H2&+0&D2:8]1-[C&H1&+0&D3:5]2-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[C&H1&+0&D3:2](-[C&H1&+0&D3:7]-1-[C:6])-[C:1]-2|[CH2:1]=[CH:2][C:3](=[O:4])[O:5][CH3:6].[CH:7]1[CH:8]=[CH:9][CH2:10][CH:11]=1>>[CH3:6][O:5][C:3](=[O:4])[CH:2]1[CH2:1][CH:9]2[CH:8]=[CH:7][CH:11]1[CH2:10]2|US20040023152A1_0153
4.1.59|[C:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C&H0&+0&D2:5]#[N&H0&+0&D1:4])=O.[C:3]-[N&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:1]:[n&H0&+0&D3:2](-[C:3]):[c&H0&+0&D3:5](-[N&H2&+0&D1:4]):[c&H1&+0&D2:6]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=O)[CH2:6][C:7]#[N:8].[N:9]#[C:10][CH2:11][CH2:12][NH:13][NH2:14]>>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([n:13]([n:14]1)[CH2:12][CH2:11][C:10]#[N:9])[NH2:8]|US20190375714A1_0877
4.1.45|[C&H3&D1:9]-[C&H0&+0&D4:8](-O-C)(-O-C)-O-C.[N&H2&+0&D1:7]-[c:6]:[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[CH3:8])[NH:9][c:10]1[n:11][c:12]([cH:13][c:14]([c:15]1[NH2:16])[NH:17][CH:18]([CH2:19][CH3:20])[CH2:21][CH3:22])[CH3:23])[CH3:24].CO[C:25]([CH3:26])(OC)OC>Cc1ccc(cc1)S(=O)(=O)O.Cc1ccccc1.O>[CH3:22][CH2:21][CH:18]([CH2:19][CH3:20])[NH:17][c:14]1[cH:13][c:12]([n:11][c:10]2[c:15]1[n:16][c:25]([n:9]2-[c:5]1[c:6]([cH:7][c:2]([cH:3][c:4]1[CH3:24])[CH3:1])[CH3:8])[CH3:26])[CH3:23]|US04963560A
4.1.59|[C:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D2:4]#[N&H0&+0&D1:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:4](-[N&H2&+0&D1:3]):[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([CH:11]([CH2:12]1)[C:13]#[N:14])=O.[NH2:15][NH2:16]>CCOC(C)=O.O=C(O)O[Na].CCO.Cl>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:12][c:11]2[c:13]([n:15][nH:16][c:10]2[CH2:9]1)[NH2:14]|US09763922B2_0356
4.1.24|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[n:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#11]>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[n:4]|[N-:1]=[N+:2]=[N:3][Na].[N:4]#[C:5][c:6]1[cH:7][c:8]2[c:9]3[cH:10][cH:11][cH:12][cH:13][c:14]3[nH:15][c:16]([n:17]2[n:18]1)=[O:19]>[NH4+].O.[Cl-].Cl.CN(C)C=O>[O:19]=[c:16]1[nH:15][c:14]2[cH:13][cH:12][cH:11][cH:10][c:9]2[c:8]2[cH:7][c:6]([n:18][n:17]12)-[c:5]1[n:4][n:1][n:2][nH:3]1|US20200375946A1_0993
4.1.59|[C:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D2:4]#[N&H0&+0&D1:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](-[N&H2&+0&D1:3]):[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([CH:11]([CH2:12]1)[C:13]#[N:14])=O.[NH2:15][NH2:16].Cl>[O-]C(=O)O.CCO.[Na+]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[n:15][nH:16][c:13]([c:11]2[CH2:12]1)[NH2:14]|US20100152205A1_0208
4.1.13|[N&H2&+0&D1:9]-[N&H2&+0&D1:8].[c:7]:[c&H0&+0&D3:6](:[c:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)-F>>[n&H0&+0&D2:9]1:[n&H1&+0&D2:8]:[c&H0&+0&D3:6](:[c:7]):[c:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[O:11][c:12]1[cH:13][cH:14][c:15]([c:16]2[c:17]1[C:18]([c:19]1[cH:20][cH:21][n:22][cH:23][c:24]1[C:25]2=O)=[O:26])F.[NH2:27][NH2:28]>Cc1ccc(cc1)S(=O)(=O)Oc1ccc(c2c1C(c1ccncc1C2=O)=O)Cl.CC(C)(C)OC(=O)NCCCl.CC(C)N(CC)C(C)C.C1CCOC1>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[S:8](=[O:9])(=[O:10])[O:11][c:12]1[cH:13][cH:14][c:15]2[nH:28][n:27][c:25]3[c:16]2[c:17]1[C:18]([c:19]1[c:24]-3[cH:23][n:22][cH:21][cH:20]1)=[O:26]|US20090124607A1_0520
2.1.2|[C:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-[N&H1&+0&D2:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O>>[C:9]-[n&H0&+0&D3:8]1:[c&H0&+0&D3:2](=[O&H0&D1:1]):[c:3]:[c:4]:[n&H1&+0&D2:5]:[c&H0&+0&D3:7]:1=[O&H0&D1:6]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[CH2:15][CH2:16][NH:17][C:18](=[O:19])[NH:20][c:21]1[cH:22][o:23][cH:24][c:25]1[C:26](=[O:27])O>O=C(n1cncc1)n1cncc1.C1CCOC1>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][CH2:14]1)[CH2:15][CH2:16][n:17]1[c:26]([c:25]2[cH:24][o:23][cH:22][c:21]2[nH:20][c:18]1=[O:19])=[O:27]|US20130053407A1_0392
4.1.13|[N&H2&+0&D1:9]-[N&H2&+0&D1:8].[c:7]:[c&H0&+0&D3:6](:[c:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)-Cl>>[n&H1&+0&D2:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:4](:[c:5]:[c&H0&+0&D3:6]:1:[c:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|O.[CH3:1][CH2:2][n:3]1[n:4][cH:5][c:6]2[c:7]1[n:8][c:9]1[CH2:10][CH2:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[C:18]([c:19]1[c:20]2Cl)=O.[NH2:21][NH2:22]>CCO>[CH3:1][CH2:2][n:3]1[n:4][cH:5][c:6]2[c:7]1[n:8][c:9]1[CH2:10][CH2:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3-[c:18]3[n:21][nH:22][c:20]2[c:19]13|US20110269810A1_0280
4.1.12|[N&H2&+0&D1:9]-[c:8]:[n&H0&+0&D2:7]:[c:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H1&+0&D3:2](-[C&H1&+0&D2:1]=O)-Br>>[n&H0&+0&D2:9]1:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](:[n&H0&+0&D3:7](:[c:6]):[c:8]:1)-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][n:10][c:11]1[NH2:12].O=[CH:13][CH:14](Br)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O.O=C(O[K])O[K]>[CH3:1][C:2](=[O:3])[O:4][CH2:5][c:6]1[cH:7][cH:8][cH:9][n:10]2[c:14]([cH:13][n:12][c:11]12)-[c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1|US10479792B2_0597
4.1.13|[N&H2&+0&D1:9]-[N&H2&+0&D1:8].[c:7]:[c&H0&+0&D3:6](:[c:5])-[C&H0&+0&D3:4](-[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl)=O>>[n&H0&+0&D2:9]1:[n&H1&+0&D2:8]:[c&H0&+0&D3:2](:[n:1]):[c:3]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:6](:[c:7]):[c:5]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[C:16](=O)[c:17]1[cH:18][cH:19][cH:20][n:21][c:22]1Cl.[NH2:23][NH2:24].O>c1ccncc1>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])-[c:16]1[n:23][nH:24][c:22]2[n:21][cH:20][cH:19][cH:18][c:17]12|US20190307745A1_0136
4.3.3|[C&H3&D1:8]-[C&H0&+0&D3:7](-[N&H2&+0&D1:6])=[S&H0&+0&D1:5].[C:4]-[C&H1&+0&D3:3](-[C&H0&+0&D3:2](-[C:1])=O)-Br>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:2](-[C:1]):[c&H0&+0&D3:3](-[C:4]):[s&H0&+0&D2:5]:1|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:7][CH2:8][CH2:9][CH:10]([C:11]1=O)Br.[CH3:12][C:13]([NH2:14])=[S:15]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]1[CH2:7][CH2:8][CH2:9][c:10]2[s:15][c:13]([n:14][c:11]21)[CH3:12]|US20110195968A1_0452
4.1.13|[N&H2&+0&D1:9]-[N&H2&+0&D1:8].[c:7]:[c&H0&+0&D3:6](:[n:5])-[C&H0&+0&D3:4](-[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl)=O>>[n&H0&+0&D2:9]1:[n&H1&+0&D2:8]:[c&H0&+0&D3:2](:[n:1]):[c:3]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:6](:[c:7]):[n:5]|O.[CH3:1][c:2]1[cH:3][c:4]([c:5]([nH:6]1)[C:7](=O)[c:8]1[cH:9][cH:10][cH:11][n:12][c:13]1Cl)[CH3:14].[NH2:15][NH2:16]>CCO>[CH3:14][c:4]1[cH:3][c:2]([nH:6][c:5]1-[c:7]1[n:15][nH:16][c:13]2[n:12][cH:11][cH:10][cH:9][c:8]21)[CH3:1]|US08809335B2_0289
2.3.10|[C:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-[c:5]:[c:4]-[N&H1&+0&D2:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C>>[C:9]-[n&H0&+0&D3:8]1:[c&H0&+0&D3:2](=[O&H0&D1:1]):[n&H1&+0&D2:3]:[c:4]:[c:5]:[c&H0&+0&D3:7]:1=[O&H0&D1:6]|CO[C:1](=[O:2])[NH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[C:10](=[O:11])[NH:12][CH:13]1[CH2:14][CH2:15]1>[Na+].C[O-].CO>[O:11]=[c:10]1[c:9]2[cH:8][cH:7][cH:6][cH:5][c:4]2[nH:3][c:1]([n:12]1[CH:13]1[CH2:14][CH2:15]1)=[O:2]|US20170137387A1_0288
4.1.111|[C:9]-[N&H1&+0&D2:8]-[C:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O)-O>>[C:9]-[N&H0&+0&D3:8]1-[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]([CH2:6][CH3:7])[CH2:8][NH:9][C:10]([NH2:11])=[O:12].[O:13]=[C:14](O)[CH2:15][C:16](=[O:17])O>CC(=O)O>[CH3:1][CH2:2][CH2:3][CH2:4][CH:5]([CH2:6][CH3:7])[CH2:8][N:9]1[C:14]([CH2:15][C:16]([NH:11][C:10]1=[O:12])=[O:17])=[O:13]|US07737144B2_0160
4.1.49|[C&H3&D1:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C:6])=O.[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[c&H0&+0&D3:4](-[N&H2&+0&D1:5]):[c&H0&+0&D3:7]:1-[C:6]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]([CH3:8])=O.[N:9]#[C:10][c:11]1[c:12]2[CH2:13][CH2:14][CH2:15][CH2:16][c:17]2[n:18]([c:19]1[NH2:20])[CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>O.[Na+].Cl.CCO.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O.CC[O-]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:10]([c:11]2[c:12]3[CH2:13][CH2:14][CH2:15][CH2:16][c:17]3[n:18]([c:19]2[n:20][c:7]1[CH3:8])[CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[NH2:9]|US20160185727A1_0246
4.1.59|[C:8]-[C&H0&+0&D3:7](-[C&H0&+0&D2:6]#[N&H0&+0&D1:5])=[C&H1&+0&D2:4]-O-C-C.[C:3]-[N&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[c&H0&+0&D3:6](-[N&H2&+0&D1:5]):[n&H0&+0&D3:2](-[C:3]):[n&H0&+0&D2:1]:[c&H1&+0&D2:4]:1|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][NH2:7].CCO[CH:8]=[C:9]([C:10]#[N:11])[C:12]#[N:13]>CCO>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][n:6]1[n:7][cH:8][c:9]([c:12]1[NH2:13])[C:10]#[N:11]|US20140088081A1_0182
4.3.3|[N&H2&+0&D1:8]-[C&H0&+0&D3:7](=[S&H0&+0&D1:6])-[c&H0&+0&D3:5](:[c:4]):[c:3].[C&H1&+0&D2:2](-[C&H2&+0&D2:1]-Cl)=O>>[n&H0&+0&D2:8]1:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:5](:[c:4]):[c:3]|[CH3:1][c:2]1[cH:3][c:4]([o:5][n:6]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[C:19]([NH2:20])=[S:21].O=[CH:22][CH2:23]Cl>CCO>[CH3:1][c:2]1[cH:3][c:4]([o:5][n:6]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)-[c:19]1[n:20][cH:22][cH:23][s:21]1|US20140249024A1_0584
4.2.4|[O&H0&+0&D1:8]=[C&H0&+0&D3:7](-[C&H1&+0&D2:6]=[C&H1&+0&D2:5]-[N&H0&+0&D3:4](-C)-C)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[o&H0&+0&D2:8]1:[c&H0&+0&D3:7](:[c&H1&+0&D2:6]:[c&H1&+0&D2:5]:[n&H0&+0&D2:4]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=[O:9])[CH:10]=[CH:11][N:12](C)C>O.CO.NOS(=O)(=O)O.O=C(O)O[Na]>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[cH:10][cH:11][n:12][o:9]1|US07786110B2_0716
4.1.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[C:4]-[N&H0&+0&D2:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[c&H1&+0&D2:9]1:[n&H0&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D3:3](-[C:4]):[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[N-:1]=[N+:2]=[N:3][CH:4]1[CH2:5][CH2:6][N:7]([CH2:8]1)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH:16]#[C:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>CCCCCC.c1ccccc1.ClC(Cl)Cl.CO>[cH:13]1[cH:12][cH:11][c:10]([cH:15][cH:14]1)[CH2:9][N:7]1[CH2:6][CH2:5][CH:4]([CH2:8]1)[n:3]1[n:2][n:1][cH:16][c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20160176824A1_0328
4.1.60|[N&H2&+0&D1:8]-[N&H2&+0&D1:7].[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H1&+0&D2:8]1:[n&H0&+0&D2:7]:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3]:1-[c&H0&+0&D3:5](:[c:6]):[c:4]|O.[CH3:1][n:2]1[c:3]([c:4]([cH:5][c:6]2[c:7]1[n:8]([c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]21)[C:15](=O)[CH:16]=[CH:17]N(C)C)[CH3:18])-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Br:25])=[O:26].[NH2:27][NH2:28]>>[CH3:1][n:2]1[c:3]([c:4]([cH:5][c:6]2[c:7]1[n:8]([c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]21)-[c:15]1[cH:16][cH:17][n:27][nH:28]1)[CH3:18])-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Br:25])=[O:26]|US20120101100A1_1452
4.1.60|[N&H2&+0&D1:8]-[N&H2&+0&D1:7].[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:8]1:[n&H1&+0&D2:7]:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3]:1-[c&H0&+0&D3:5](:[c:6]):[c:4]|O.CN(C)[CH:1]=[CH:2][C:3](=O)[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[O:10][CH2:11][CH:12]([OH:13])[CH2:14][N:15]1[CH2:16][CH2:17][N:18]([CH2:19][CH2:20]1)[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[Cl:27].[NH2:28][NH2:29]>Cl.CCO>[OH:13][CH:12]([CH2:11][O:10][c:9]1[cH:8][cH:7][cH:6][cH:5][c:4]1-[c:3]1[cH:2][cH:1][nH:28][n:29]1)[CH2:14][N:15]1[CH2:16][CH2:17][N:18]([CH2:19][CH2:20]1)[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[Cl:27]|US20110053935A1_0186
4.1.113|[N&H2&+0&D1:9]-[c:8]:[n&H1&+0&D2:7]:[n:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C)-O-C>>[N&H1&+0&D2:9]1-[c:8]:[n&H0&+0&D3:7](:[n:6])-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|[CH3:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[CH2:8][c:9]1[c:10]([n:11][nH:12][c:13]1[NH2:14])[CH3:15])[C:16]([F:17])([F:18])[F:19].CO[C:20](=[O:21])[CH2:22][C:23](=[O:24])OC>C[O-].CO.[Na+]>[CH3:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[CH2:8][c:9]1[c:10]([n:11][n:12]2[C:23]([CH2:22][C:20]([NH:14][c:13]12)=[O:21])=[O:24])[CH3:15])[C:16]([F:17])([F:18])[F:19]|US20120277224A1_1293
4.1.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[c&H0&+0&D3:7](:[n:6]):[s:5].[C:4]-[N&H0&+0&D2:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](:[n&H0&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D3:3]:1-[C:4])-[c&H0&+0&D3:7](:[n:6]):[s:5]|[CH:1]#[C:2][c:3]1[n:4][c:5]([c:6]([s:7]1)[C:8](=[O:9])[NH:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[CH3:18].[N-:19]=[N+:20]=[N:21][CH2:22][CH2:23][c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30]>CC(C)N(CC)C(C)C.C1CCOC1.I[Cu]>[CH3:18][c:5]1[n:4][c:3]([s:7][c:6]1[C:8](=[O:9])[NH:10][CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)-[c:2]1[cH:1][n:21]([n:20][n:19]1)[CH2:22][CH2:23][c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30]|US20110166152A1_0268
4.1.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[C:7].[N&H0&-&D1:6]=[N&H0&+&D2:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](-[C:7]):[n&H0&+0&D2:6]:[n&H0&+0&D2:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH:1]#[C:2][C:3](=[O:4])[O:5][CH3:6].[N-:7]=[N+:8]=[N:9][c:10]1[cH:11][n:12][cH:13][cH:14][n:15]1>>[CH3:6][O:5][C:3](=[O:4])[c:2]1[cH:1][n:9]([n:8][n:7]1)-[c:10]1[cH:11][n:12][cH:13][cH:14][n:15]1|EP3083601B1_0231
3.11.3|[C&H2&+0&D1:8]=[C&H1&+0&D2:7]-[C:6].[C&H2&+0&D1:5]=[C&H1&+0&D2:4]-[C&H0&+0&D3:3](=[C&H2&+0&D1:2])-[C&H3&D1:1]>>[C&H2&+0&D2:8]1-[C&H2&+0&D2:2]-[C&H0&+0&D3:3](-[C&H3&D1:1])=[C&H1&+0&D2:4]-[C&H2&+0&D2:5]-[C&H1&+0&D3:7]-1-[C:6]|[CH2:1]=[CH:2][CH:3]=[O:4].[CH2:5]=[CH:6][C:7](=[CH2:8])[CH3:9]>>[CH3:9][C:7]1=[CH:6][CH2:5][CH:2]([CH2:1][CH2:8]1)[CH:3]=[O:4]|US09452154B2_0340
4.1.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[C:7].[N&H0&-&D1:6]=[N&H0&+&D2:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](-[C:7]):[n&H0&+0&D2:6]:[n&H0&+0&D2:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH:1]#[C:2][C:3]1=[CH:4][CH2:5][N:6]([CH2:7][CH2:8]1)[C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15].[N-:16]=[N+:17]=[N:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>Cc1ccccc1>[CH3:13][C:12]([CH3:14])([CH3:15])[O:11][C:9](=[O:10])[N:6]1[CH2:5][CH:4]=[C:3]([CH2:8][CH2:7]1)[c:2]1[cH:1][n:18]([n:17][n:16]1)-[c:19]1[cH:24][cH:23][cH:22][cH:21][cH:20]1|EP3083601B1_0206
4.1.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[n:5].[C:4]-[N&H0&+0&D2:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](:[n&H0&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D3:3]:1-[C:4])-[c&H0&+0&D3:7](:[c:6]):[n:5]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][c:7]([n:8]1)[NH2:9].[CH3:10][C:11](=[O:12])[O:13][CH2:14][CH:15]1[CH2:16][CH:17]([CH:18]([CH:19]([O:20]1)[O:21][C@@H:22]1[C@H:23]([C:24]([C@:25]([C:26]([O:27][C@@H:28]([C@:29]2([O:30][C:31]([N@@:32]([C@@H:33]2[C@H:34]([C:35]([C@@H:36]([CH2:37][C@:38]1([CH3:39])[O:40][CH3:41])[CH3:42])=[O:43])[CH3:44])[CH2:45][CH2:46][CH2:47][CH2:48][N:49]=[N+:50]=[N-:51])=[O:52])[CH3:53])[CH2:54][CH3:55])=[O:56])([CH3:57])[F:58])=[O:59])[CH3:60])[OH:61])[N:62]([CH3:63])[CH3:64]>I[Cu]>[CH3:44][C@H:34]1[C:35]([C@@H:36]([CH2:37][C@:38]([C@@H:22]([C@H:23]([C:24]([C@:25]([C:26]([O:27][C@@H:28]([C@@:29]2([C@@H:33]1[N@:32]([C:31]([O:30]2)=[O:52])[CH2:45][CH2:46][CH2:47][CH2:48][n:49]1[cH:1][c:2]([n:51][n:50]1)-[c:3]1[cH:4][cH:5][cH:6][c:7]([n:8]1)[NH2:9])[CH3:53])[CH2:54][CH3:55])=[O:56])([CH3:57])[F:58])=[O:59])[CH3:60])[O:21][CH:19]1[O:20][CH:15]([CH2:16][CH:17]([CH:18]1[OH:61])[N:62]([CH3:63])[CH3:64])[CH2:14][O:13][C:11]([CH3:10])=[O:12])([CH3:39])[O:40][CH3:41])[CH3:42])=[O:43]|US20120283249A1_0244
4.1.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[C:4]-[N&H0&+0&D2:3]=[N&H0&+&D2:2]=[N&H0&-&D1:1]>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](:[n&H0&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D3:3]:1-[C:4])-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[F:9].[CH3:10][CH:11]([CH3:12])[N:13]=[N+:14]=[N-:15]>>[CH3:10][CH:11]([CH3:12])[n:13]1[cH:1][c:2]([n:15][n:14]1)-[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[F:9]|EP3313840B1_0199
4.1.48|[C:8]-[C&H0&+0&D3:7](=[N&H1&+0&D1:6])-[N&H2&+0&D1:5].[C:4]-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:5]:1|CN(C)[CH:1]=[CH:2][C:3](=O)[CH:4]([O:5][CH3:6])[O:7][CH3:8].[NH:9]=[C:10]([NH2:11])[CH:12]1[CH2:13][CH2:14][CH2:15]1.Cl>CCN(CC)CC.CCO>[CH3:8][O:7][CH:4]([O:5][CH3:6])[c:3]1[cH:2][cH:1][n:9][c:10]([n:11]1)[CH:12]1[CH2:15][CH2:14][CH2:13]1|US20190055264A1_0974
2.1.2|[N&H2&+0&D1:9]-[c:8].[O&H0&D1:7]=[C&H0&+0&D3:6](-[C&H1&+0&D3:5](-[O&H1&D1:4])-[C&H1&+0&D3:3](-[S:2])-[c:1])-O>>[N&H1&+0&D2:9](-[c:8])-[C&H0&+0&D3:6](=[O&H0&D1:7])-[C@@&H1&+0&D3:5](-[O&H1&D1:4])-[C@&H1&+0&D3:3](-[S:2])-[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH:9]([S:10][c:11]1[cH:12][c:13]([cH:14][cH:15][c:16]1[NH2:17])[O:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[CH:25]([OH:26])[C:27](=[O:28])O>CN(C)C=O.CN1CCOCC1.[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1.Cl[Na]>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C@@H:9]1[S:10][c:11]2[cH:12][c:13]([cH:14][cH:15][c:16]2[NH:17][C:27]([C@@H:25]1[OH:26])=[O:28])[O:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|EP0158339B1_0073
4.2.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[C:7].[O&H1&+0&D1:6]-[N&H0&+0&D2:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](-[C:7]):[o&H0&+0&D2:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][c:2]1[c:3]([n:4][cH:5][n:6]1-[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[O:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[CH:20]=[N:21][OH:22].[CH:23]#[C:24][CH2:25][O:26][CH3:27]>O=C1CCC(N1Br)=O.CCN(CC)CC.CN(C)C=O.Cl>[CH3:1][c:2]1[c:3]([n:4][cH:5][n:6]1-[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[O:13][c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)-[c:20]1[cH:23][c:24]([o:22][n:21]1)[CH2:25][O:26][CH3:27]|US20200399279A1_0995
4.1.14|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[C&H3&D1:3])=O)=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D3:1](-[C:2]):[c&H0&+0&D3:4](-[C&H3&D1:3]):[c&H1&+0&D2:5]:[c&H1&+0&D2:6]:1|Cl.[CH3:1][O:2][C:3](=[O:4])[CH2:5][NH2:6].[CH3:7][C:8](=O)[CH2:9][CH2:10][C:11]([CH3:12])=O>O.[Na+].CC([O-])=O.CC(=O)O>[CH3:7][c:8]1[cH:9][cH:10][c:11]([n:6]1[CH2:5][C:3](=[O:4])[O:2][CH3:1])[CH3:12]|US20200199113A1_0102
4.1.59|[C&H3&D1:8]-[N&H1&+0&D2:7]-[N&H2&+0&D1:6].[C:5]-[C&H0&+0&D3:4](-[C&H2&+0&D2:3]-[C&H0&+0&D2:2]#[N&H0&+0&D1:1])=O>>[C&H3&D1:8]-[n&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:4](-[C:5]):[c&H1&+0&D2:3]:[c&H0&+0&D3:2]:1-[N&H2&+0&D1:1]|[CH3:1][NH:2][NH2:3].[N:4]#[C:5][CH2:6][C:7](=O)[CH:8]1[CH2:9][CH:10]=[CH:11][CH2:12][CH2:13]1>CCO>[CH3:1][n:2]1[n:3][c:7]([cH:6][c:5]1[NH2:4])[CH:8]1[CH2:13][CH2:12][CH:11]=[CH:10][CH2:9]1|US20200129627A1_2683
4.1.1|[C&H1&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[c:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#14](-C)(-C)-C>>[c&H1&+0&D2:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|[CH:1]#[C:2][c:3]1[cH:4][c:5]([c:6]([cH:7][c:8]1[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[O:17][CH2:18][CH2:19][CH2:20][O:21][c:22]1[cH:23][cH:24][cH:25][c:26]([c:27]1[CH2:28][CH2:29][CH3:30])[O:31][c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1[C:38](=[O:39])[O:40][CH3:41])[CH2:42][CH3:43].C[Si](C)(C)[N:44]=[N+:45]=[N-:46]>Cc1ccccc1>[CH3:30][CH2:29][CH2:28][c:27]1[c:26]([cH:25][cH:24][cH:23][c:22]1[O:21][CH2:20][CH2:19][CH2:18][O:17][c:6]1[cH:7][c:8]([c:3]([cH:4][c:5]1[CH2:42][CH3:43])-[c:2]1[cH:1][n:46][n:45][nH:44]1)[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[O:31][c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1[C:38](=[O:39])[O:40][CH3:41]|EP3553057A1_0136
4.1.24|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[n:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#14](-C)(-C)-C>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[n:4]|[CH3:1][c:2]1[n:3][c:4]([cH:5][s:6]1)[C:7]#[N:8].C[Si](C)(C)[N:9]=[N+:10]=[N-:11]>CCCC[Sn](=O)CCCC.Cc1ccccc1.CCOC(C)=O>[CH3:1][c:2]1[n:3][c:4]([cH:5][s:6]1)-[c:7]1[n:8][n:11][n:10][nH:9]1|US20100113507A1_0172
4.1.1|[C&H1&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[c:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#14](-C)(-C)-C>>[c&H1&+0&D2:8]1:[n&H1&+0&D2:3]:[n&H0&+0&D2:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.C[Si](C)(C)[N:9]=[N+:10]=[N-:11]>CCCCCC.CCOCC>[cH:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)-[c:2]1[cH:1][nH:11][n:10][n:9]1|US20180118718A1_0674
4.1.24|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[c:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#14](-C)(-C)-C>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[C:14]#[N:15].C[Si](C)(C)[N:16]=[N+:17]=[N-:18]>CCCC[Sn](=O)CCCC.Cc1ccccc1>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1-[c:14]1[n:15][n:18][n:17][nH:16]1|US20190210978A1_0701
4.2.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[C:7].[O&H1&+0&D1:6]/[N&H0&+0&D2:5]=[C&H1&+0&D2:4]/[c&H0&+0&D3:3](:[c:2]):[c:1]>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](-[C:7]):[o&H0&+0&D2:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[OH:1]/[N:2]=[CH:3]/[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[F:10].[CH:11]#[C:12][CH2:13][O:14][C:15]([CH3:16])=[O:17]>O=C1CCC(N1Cl)=O.CCN(CC)CC.ClCCl>[CH3:16][C:15](=[O:17])[O:14][CH2:13][c:12]1[cH:11][c:3]([n:2][o:1]1)-[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[F:10]|US20200181086A1_0899
4.1.55|[C:10]-[C&H0&+0&D3:9](-[C&H0&+0&D3:8](-[C:7])=[C&H1&+0&D2:6]-[c:5])=O.[C:4]-[C&H1&+0&D2:3]=[C:2]-[N&H2&+0&D1:1]>>[C:10]-[C&H0&+0&D3:9]1-[N&H1&+0&D2:1]-[C:2]=[C&H0&+0&D3:3](-[C:4])-[C&H1&+0&D3:6](-[c:5])-[C&H0&+0&D3:8]=1-[C:7]|Cl.[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]=[C:7]([NH2:8])[NH2:9].[CH3:10][CH2:11][O:12][C:13](=[O:14])[C:15](=[CH:16][c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)[N+:23]([O-:24])=[O:25])[C:26](=O)[CH2:27][F:28]>CCO.[Na]>[CH3:10][CH2:11][O:12][C:13](=[O:14])[C:15]1=[C:26]([NH:9][C:7](=[C:6]([CH:16]1[c:17]1[cH:18][cH:19][cH:20][c:21]([cH:22]1)[N+:23]([O-:24])=[O:25])[C:4](=[O:5])[O:3][CH2:2][CH3:1])[NH2:8])[CH2:27][F:28]|EP1888589B1_0162
4.1.24|[N&H0&+0&D1:8]#[C&H0&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[c:4].[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#50](-C)(-C)-C>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|[CH3:1][CH2:2][c:3]1[n:4][c:5]2[c:6]([cH:7][c:8]([n:9][c:10]2[n:11]1[CH2:12][c:13]1[cH:14][cH:15][c:16]2[c:17]([cH:18][cH:19][n:20]2[C:21](=[O:22])[c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[C:29]#[N:30])[cH:31]1)[CH3:32])[CH3:33].C[Sn](C)(C)[N:34]=[N+:35]=[N-:36]>Cc1ccccc1>[CH3:1][CH2:2][c:3]1[n:4][c:5]2[c:6]([cH:7][c:8]([n:9][c:10]2[n:11]1[CH2:12][c:13]1[cH:14][cH:15][c:16]2[c:17]([cH:18][cH:19][n:20]2[C:21](=[O:22])[c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2-[c:29]2[n:30][n:36][n:35][nH:34]2)[cH:31]1)[CH3:32])[CH3:33]|US20090291968A1_0322
4.1.10|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-O-C)=O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[c&H0&+0&D3:6](:[n&H1&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1])=[O&H0&D1:5]|[CH3:1][C:2]([CH3:3])([CH3:4])[n:5]1[n:6][c:7]([cH:8][c:9]1[NH2:10])[CH:11]1[CH2:12][CH2:13][CH2:14]1.CO[C:15](=[O:16])[CH2:17][C:18](=O)[C:19]([F:20])([F:21])[F:22]>CC(=O)O>[CH3:1][C:2]([CH3:3])([CH3:4])[n:5]1[n:6][c:7]([c:8]2[c:18]([cH:17][c:15]([nH:10][c:9]21)=[O:16])[C:19]([F:20])([F:21])[F:22])[CH:11]1[CH2:12][CH2:13][CH2:14]1|EP3569596A1_0292
4.1.8|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D3:4](-[C&H3&D1:3])=O)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:4](-[C&H3&D1:3]):[c&H0&+0&D3:6]:1-[C:5]|O.[CH3:1][C:2](=O)[CH:3]([CH2:4][C:5](=[O:6])[O:7][CH2:8][CH3:9])[C:10]([CH3:11])=O.[NH2:12][NH2:13]>CO.CC(=O)O>[CH3:9][CH2:8][O:7][C:5](=[O:6])[CH2:4][c:3]1[c:2]([n:12][nH:13][c:10]1[CH3:11])[CH3:1]|US20090270361A1_1341
4.2.4|[N&H2&+0&D1:8]-[O&H1&+0&D1:7].[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:8]1:[o&H0&+0&D2:7]:[c&H0&+0&D3:3](:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:1)-[c&H0&+0&D3:5](:[c:6]):[c:4]|Cl.CN(C)[CH:1]=[CH:2][C:3](=O)[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[N+:10]([O-:11])=[O:12].[NH2:13][OH:14]>CCO>[O-:11][N+:10](=[O:12])[c:9]1[cH:8][cH:7][cH:6][cH:5][c:4]1-[c:3]1[cH:2][cH:1][n:13][o:14]1|US10689414B2_0739
4.2.37|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-O-C)=O.[O&H1&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[c&H0&+0&D3:6](=[O&H0&D1:5]):[o&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1]|CO[C:1](=[O:2])[CH2:3][C:4](=O)[C:5]([F:6])([F:7])[F:8].[OH:9][c:10]1[c:11]([cH:12][cH:13][c:14]([c:15]1[F:16])[OH:17])[F:18]>O>[O:2]=[c:1]1[cH:3][c:4]([c:13]2[cH:12][c:11]([c:10]([c:15]([c:14]2[o:17]1)[F:16])[OH:9])[F:18])[C:5]([F:6])([F:7])[F:8]|US20200354484A1_0141
4.2.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[C:7].[O&H1&+0&D1:6]-[N&H0&+0&D2:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](-[C:7]):[o&H0&+0&D2:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH:1]#[C:2][CH2:3][Br:4].[OH:5][N:6]=[CH:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>O.ClCCl.[Na]>[Br:4][CH2:3][c:2]1[cH:1][c:7]([n:6][o:5]1)-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US08969349B2_0580
4.1.29|[C:10]-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[C&H1&+0&D2:1]=O>>[C:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[N:1]#[C:2][CH2:3][C:4](=O)[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[F:11].[NH2:12][c:13]1[cH:14][cH:15][cH:16][n:17][c:18]1[CH:19]=O>CCOC(C)=O.C1CCNCC1>[N:1]#[C:2][c:3]1[cH:19][c:18]2[n:17][cH:16][cH:15][cH:14][c:13]2[n:12][c:4]1-[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[F:11]|US10336723B2_0345
1.6.4|[C:9]-[C&H0&+0&D3:8](=[N&H1&+0&D1:7])-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:2](:[n:1]):[c:3]:[c&H0&+0&D3:5](=[O&H0&D1:4]):[n&H1&+0&D2:6]:1|[NH:1]=[C:2]([CH2:3][O:4][CH2:5][CH2:6][c:7]1[cH:8][c:9]([cH:10][cH:11][c:12]1[F:13])[F:14])[NH:15][C:16](=[O:17])[c:18]1[cH:19][c:20]([cH:21][n:22][c:23]1Cl)[Cl:24]>O.CC(=O)OC(C)C.CS(C)=O.CC(C)(C)[O-].[K+]>[O:17]=[c:16]1[nH:15][c:2]([n:1][c:23]2[n:22][cH:21][c:20]([cH:19][c:18]21)[Cl:24])[CH2:3][O:4][CH2:5][CH2:6][c:7]1[cH:8][c:9]([cH:10][cH:11][c:12]1[F:13])[F:14]|US07928106B2_0231
4.1.35|[C:10]-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[C:10]-[c&H0&+0&D3:9]1:[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:14](=[O:15])[CH:16]1[CH2:17][C:18]([c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[S:25]1)=O.N[NH:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1>>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:14](=[O:15])[CH:16]1[S:25][c:24]2[cH:23][cH:22][cH:21][cH:20][c:19]2-[c:18]2[nH:26][c:27]3[cH:28][cH:29][cH:30][cH:31][c:32]3[c:17]21|US08506932B2_0198
4.1.8|[C&H3&D1:9]-[N&H1&+0&D2:8]-[N&H2&+0&D1:7].[C:6]-[C&H0&+0&D3:5](-[C&H1&+0&D3:4](-[C:3])-[C&H0&+0&D3:2](-[C:1])=O)=O>>[C&H3&D1:9]-[n&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:2](-[C:1]):[c&H0&+0&D3:4](-[C:3]):[c&H0&+0&D3:5]:1-[C:6]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH:12]([CH2:13]1)[C:14](=O)[C:15]([F:16])([F:17])[F:18])=O.[CH3:19][NH:20][NH2:21]>C1CCNCC1.CCO>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][c:11]2[c:12]([CH2:13]1)[c:14]([n:21][n:20]2[CH3:19])[C:15]([F:16])([F:17])[F:18]|EP3313397B1_0254
4.1.35|[c:10]:[c&H0&+0&D3:9]1:[c:8]-[C:7]-[C&H2&+0&D2:6]-[C&H0&+0&D3:5]-1=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[c:10]:[c&H0&+0&D3:9]1:[c:8]-[C:7]-[c&H0&+0&D3:6]2:[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:5]:2-1|[CH3:1][CH:2]1[CH2:3][C:4]([c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]21)=O.N[NH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>O.O.Cl.CC(=O)O>[CH3:1][CH:2]1[c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]2-[c:4]2[nH:11][c:12]3[cH:17][cH:16][cH:15][cH:14][c:13]3[c:3]21|US08153671B2_0169
4.1.11|[C&H1&+0&D1:10]#[C&H0&+0&D2:9]-[c&H0&+0&D3:8](:[c:7]):[c:6].[S:5]-[N&H1&+0&D2:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[c&H1&+0&D2:10]1:[c&H0&+0&D3:9](:[n&H0&+0&D3:4](-[S:5]):[c:3]:[c&H0&+0&D3:2]:1:[c:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][N:16]([CH2:17][CH2:18]1)[CH3:19].[CH3:20][S:21](=[O:22])(=[O:23])[NH:24][c:25]1[cH:26][cH:27][cH:28][cH:29][c:30]1I>Cl[Pd](Cl)([P](c1ccccc1)(c1ccccc1)c1ccccc1)[P](c1ccccc1)(c1ccccc1)c1ccccc1.CCN(CC)CC.CN(C)C=O>[CH3:19][N:16]1[CH2:15][CH2:14][N:13]([CH2:18][CH2:17]1)[CH2:12][CH2:11][CH2:10][O:9][c:6]1[cH:7][cH:8][c:3]([cH:4][cH:5]1)-[c:2]1[cH:1][c:30]2[cH:29][cH:28][cH:27][cH:26][c:25]2[n:24]1[S:21]([CH3:20])(=[O:22])=[O:23]|EP3577115B1_0124
4.1.126|[C:9]-[C&H0&+0&D3:8](=[C&H1&+0&D2:7]-O-C-C)-[C&H0&+0&D3:6](=[O&H0&D1:5])-O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[n&H1&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6]:1=[O&H0&D1:5]|CCO[CH:1]=[C:2]([C:3](=[O:4])O)[C:5](=[O:6])[OH:7].[NH2:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[N+:15]([O-:16])=[O:17]>[Na+].CCOCC.c1ccc(cc1)Oc1ccccc1.[OH-]>[O-:16][N+:15](=[O:17])[c:14]1[cH:13][cH:12][cH:11][c:10]2[c:3]([c:2]([cH:1][nH:8][c:9]12)[C:5](=[O:6])[OH:7])=[O:4]|US20200308153A1_0279
3.11.3|[C&H2&+0&D1:9]=[C&H1&+0&D2:8]-[C:7].[C&H1&+0&D2:6]1=[C&H1&+0&D2:5]-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[C:2]-[C:1]-1>>[C&H2&+0&D2:9]1-[C&H1&+0&D3:6]2-[C&H1&+0&D2:5]=[C&H1&+0&D2:4]-[C&H1&+0&D3:3](-[C&H1&+0&D3:8]-1-[C:7])-[C:2]-[C:1]-2|[CH2:1]=[CH:2][C:3](=[O:4])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9].[CH:10]1[CH:11]=[CH:12][CH2:13][CH2:14][CH:15]=1>>[CH3:7][C:6]([CH3:8])([CH3:9])[O:5][C:3](=[O:4])[CH:2]1[CH2:1][CH:12]2[CH:11]=[CH:10][CH:15]1[CH2:14][CH2:13]2|US06307057B1
3.11.3|[C:9]-[C&H1&+0&D2:8]=[C&H1&+0&D2:7]-[C:6].[C&H1&+0&D2:5]1=[C&H1&+0&D2:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]-1>>[C:9]-[C&H1&+0&D3:8]1-[C&H1&+0&D3:2]2-[C&H1&+0&D2:3]=[C&H1&+0&D2:4]-[C&H1&+0&D3:5](-[C&H1&+0&D3:7]-1-[C:6])-[C:1]-2|[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[O:10][CH:11]1[CH:12]=[CH:13][C:14]([O:15]1)=[O:16].[CH:17]1[CH:18]=[CH:19][CH2:20][CH:21]=1>CC(=O)OCC>[O:16]=[C:14]1[O:15][CH:11]([CH:12]2[CH:21]3[CH:17]=[CH:18][CH:19]([CH2:20]3)[CH:13]12)[O:10][C:2](=[O:1])[NH:3][c:4]1[cH:9][cH:8][cH:7][cH:6][cH:5]1|US06534434B2
4.1.59|[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D2:4]#[N&H0&+0&D1:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C&H3&D1:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:4](-[N&H2&+0&D1:3]):[c&H0&+0&D3:6]:1-[C:5]|[CH3:1][C:2](=O)[CH:3]([C:4]#[N:5])[CH2:6][c:7]1[cH:8][cH:9][cH:10][c:11]([c:12]1[CH3:13])[C:14]([F:15])([F:16])[F:17].[NH2:18][NH2:19].O>CCO>[CH3:13][c:12]1[c:11]([cH:10][cH:9][cH:8][c:7]1[CH2:6][c:3]1[c:2]([n:18][nH:19][c:4]1[NH2:5])[CH3:1])[C:14]([F:15])([F:16])[F:17]|US20120277224A1_1160
3.11.3|[C:9]-[C&H1&+0&D2:8]=[C&H1&+0&D2:7]-[C:6].[C&H1&+0&D2:5]1=[C&H1&+0&D2:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]-1>>[C:9]-[C&H1&+0&D3:8]1-[C&H1&+0&D3:5]2-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[C&H1&+0&D3:2](-[C&H1&+0&D3:7]-1-[C:6])-[C:1]-2|[O:1]=[C:2]1[CH:3]=[CH:4][CH:5]([O:6]1)[OH:7].[CH:8]1[CH:9]=[CH:10][CH2:11][CH:12]=1>>[O:1]=[C:2]1[O:6][CH:5]([CH:4]2[CH:12]3[CH:8]=[CH:9][CH:10]([CH2:11]3)[CH:3]12)[OH:7]|US07592463B2_0139
4.1.42|[C:10]-[C&H0&+0&D2:9]#[C&H0&+0&D2:8]-[c:7]:[c&H0&+0&D3:6](:[n:5])-Cl.[N&H2&+0&D1:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1]):[c&H0&+0&D3:6](:[n:5]):[c:7]:[c&H1&+0&D2:8]:1|[CH3:1][CH:2]([CH3:3])[C:4]#[C:5][c:6]1[cH:7][cH:8][cH:9][n:10][c:11]1Cl.[NH2:12][c:13]1[cH:14][c:15]2[cH:16][n:17][nH:18][c:19]2[c:20]([cH:21]1)[Cl:22]>>[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][c:6]2[cH:7][cH:8][cH:9][n:10][c:11]2[n:12]1-[c:13]1[cH:14][c:15]2[cH:16][n:17][nH:18][c:19]2[c:20]([cH:21]1)[Cl:22]|US20180118740A1_1347
4.1.14|[C&H3&D1:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D3:4](-[C:3])=O)=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D3:1](-[C:2]):[c&H0&+0&D3:4](-[C:3]):[c&H0&+0&D3:6](-[C:5]):[c&H1&+0&D2:7]:1|[CH3:1][CH:2]1[CH2:3][N:4]([CH2:5][CH:6]([C:7]1=O)[CH2:8][C:9]([CH3:10])=O)[CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1.[NH2:18][CH2:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[Cl:26]>>[CH3:1][CH:2]1[CH2:3][N:4]([CH2:5][c:6]2[cH:8][c:9]([n:18]([c:7]21)[CH2:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[Cl:26])[CH3:10])[CH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US20130109721A1_0294
4.1.53|[C:9]-[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[N&H2&+0&D1:6])=O.[N&H0&+0&D1:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:5]:[c&H0&+0&D3:4](:[n&H0&+0&D2:6]:[n&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][CH2:12][CH2:13][C:14](=O)[NH:15][NH2:16])[C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23].[N:24]#[C:25][c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[C:32]([F:33])([F:34])[F:35]>CC(C)(C)O[K].CO>[CH3:21][C:20]([CH3:22])([CH3:23])[O:19][C:17](=[O:18])[C:2]([CH3:1])([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][CH2:12][CH2:13][c:14]1[n:24][c:25]([n:16][nH:15]1)-[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[C:32]([F:33])([F:34])[F:35]|US20080021217A1_0414
4.1.11|[#14:10]-[C&H0&+0&D2:9]#[C&H0&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[N&H2&+0&D1:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-I>>[#14:10]-[c&H0&+0&D3:9]1:[n&H1&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][Si:2]([CH3:3])([CH3:4])[C:5]#[C:6][c:7]1[cH:8][cH:9][o:10][cH:11]1.[NH2:12][c:13]1[n:14][cH:15][c:16]([cH:17][c:18]1I)[Br:19]>CN(C)C=O.CC([O-])=O.CC([O-])=O.CC([O-])=O.Cl[Li].[K+].[Pd+2]>[CH3:1][Si:2]([CH3:3])([CH3:4])[c:5]1[nH:12][c:13]2[n:14][cH:15][c:16]([cH:17][c:18]2[c:6]1-[c:7]1[cH:8][cH:9][o:10][cH:11]1)[Br:19]|EP3613738A1_0169
4.1.59|[C:9]-[C&H0&+0&D3:8](-[C&H1&+0&D3:7](-[C:6])-[C&H0&+0&D2:5]#[N&H0&+0&D1:4])=O.[C:3]-[N&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:1]:[n&H0&+0&D3:2](-[C:3]):[c&H0&+0&D3:5](-[N&H2&+0&D1:4]):[c&H0&+0&D3:7]:1-[C:6]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([C:7]#[N:8])[C:9](=O)[C:10]([F:11])([F:12])[F:13].[CH3:14][C:15]([CH3:16])([CH3:17])[NH:18][NH2:19].Cl>O=C(O)C(F)(F)F.CCOC(C)=O.COC(=O)OC>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:9]([n:19][n:18]([c:7]1[NH2:8])[C:15]([CH3:14])([CH3:16])[CH3:17])[C:10]([F:11])([F:12])[F:13]|US09580430B2_0706
4.1.111|[C&H3&D1:9]-[N&H1&+0&D2:8]-[C:7]-[N&H2&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O)-O>>[C&H3&D1:9]-[N&H0&+0&D3:8]1-[C:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:2](=[O&H0&D1:1])-[C:3]-[C&H0&+0&D3:4]-1=[O&H0&D1:5]|[CH3:1][NH:2][C:3]([NH2:4])=[O:5].[O:6]=[C:7](O)[CH2:8][C:9](=[O:10])O>CC(=O)O.CC(=O)OC(C)=O.CS(C)=O>[CH3:1][N:2]1[C:9]([CH2:8][C:7]([NH:4][C:3]1=[O:5])=[O:6])=[O:10]|US10421727B2_0570
4.2.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[C:7].[O&H1&+0&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Cl>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](-[C:7]):[o&H0&+0&D2:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[OH:1][N:2]=[C:3](Cl)[c:4]1[cH:5][n:6][c:7]([c:8]([cH:9]1)[Cl:10])[Cl:11].[CH:12]#[C:13][CH2:14][CH3:15]>CCN(CC)CC.CCOCC>[CH3:15][CH2:14][c:13]1[cH:12][c:3]([n:2][o:1]1)-[c:4]1[cH:5][n:6][c:7]([c:8]([cH:9]1)[Cl:10])[Cl:11]|US20100063041A1_0296
4.2.4|[N&H2&+0&D1:8]-[C&H0&+0&D3:7](=[O&H0&+0&D1:6])-[c&H0&+0&D3:5](:[c:4]):[c:3].[C&H2&+0&D2:2](-[C&H1&+0&D3:1](-O-C)-O-C)-Br>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:7](:[o&H0&+0&D2:6]:[c&H1&+0&D2:2]:[c&H1&+0&D2:1]:1)-[c&H0&+0&D3:5](:[c:4]):[c:3]|[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[n:11]([cH:12][c:13]2[C:14]([NH2:15])=[O:16])[CH2:17][CH3:18].CO[CH:19]([CH2:20]Br)OC>COCCOCCOC>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[n:11]([cH:12][c:13]2-[c:14]1[n:15][cH:19][cH:20][o:16]1)[CH2:17][CH3:18]|US20190233394A1_1011
4.2.4|[C&H1&+0&D1:9]#[C&H0&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[C:4]-[C&H0&+0&D3:3](=[N&H0&+0&D2:2]-[O&H1&+0&D1:1])-Cl>>[c&H1&+0&D2:9]1:[c&H0&+0&D3:8](:[o&H0&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:3]:1-[C:4])-[c&H0&+0&D3:7](:[c:6]):[c:5]|[OH:1][N:2]=[C:3](Cl)[CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[CH:19]#[C:20][c:21]1[cH:22][cH:23][cH:24][n:25][c:26]1[NH2:27]>CCN(CC)CC.C1CCOC1.O>[NH2:27][c:26]1[n:25][cH:24][cH:23][cH:22][c:21]1-[c:20]1[cH:19][c:3]([n:2][o:1]1)[CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US20190330198A1_1300
4.1.12|[C:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)-Br.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][n:2]1[c:3]([s:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]21)[C:11](=O)[CH:12](Br)[CH2:13][CH3:14])=[O:15].[NH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][n:22]1>>[CH3:14][CH2:13][c:12]1[c:11]([n:16][c:17]2[cH:18][cH:19][cH:20][cH:21][n:22]12)-[c:8]1[cH:7][cH:6][c:5]2[s:4][c:3]([n:2]([c:10]2[cH:9]1)[CH3:1])=[O:15]|US20200345870A1_0110
4.1.62|[C:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-O-C)=O.[N&H1&+0&D1:3]=[C&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C:8]-[c&H0&+0&D3:7]1:[n&H0&+0&D2:3]:[c&H1&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:5](=[O&H0&D1:4]):[c&H1&+0&D2:6]:1|CC(=O)O.[CH3:1][CH2:2][C:3](=O)[CH2:4][C:5](=[O:6])OC.[NH:7]=[CH:8][NH2:9]>[Na+].Cl.CO.C[O-]>[CH3:1][CH2:2][c:3]1[cH:4][c:5]([nH:9][cH:8][n:7]1)=[O:6]|EP3656384A1_0560
4.2.2|[N&H2&+0&D1:8]-[C&H0&+0&D3:7](=[N&H0&+0&D2:6]-[O&H1&+0&D1:5])-[c&H0&+0&D3:4](:[c:3]):[c:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:7](:[n&H0&+0&D2:6]:[o&H0&+0&D2:5]:[c&H1&+0&D2:1]:1)-[c&H0&+0&D3:4](:[c:3]):[c:2]|[NH2:1][C:2](=[N:3][OH:4])[c:5]1[cH:6][n:7][n:8]([cH:9]1)[CH2:10][C:11](=[O:12])[N:13]1[CH2:14][CH2:15][CH2:16][c:17]2[c:18]1[cH:19][n:20][n:21]2-[c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28].CO[CH:29](OC)OC>Cc1ccc(cc1)S(=O)(=O)O.O>[O:12]=[C:11]([CH2:10][n:8]1[cH:9][c:5]([cH:6][n:7]1)-[c:2]1[n:1][cH:29][o:4][n:3]1)[N:13]1[CH2:14][CH2:15][CH2:16][c:17]2[c:18]1[cH:19][n:20][n:21]2-[c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[F:28]|EP2295417B1_0054
4.2.3|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[n:2]):[s:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[c&H0&+0&D3:4](:[n&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[n:2]):[s:1]|[CH3:1][O:2][C:3](=[O:4])[C:5]([CH3:6])([CH3:7])[CH2:8][C:9](=[O:10])[NH:11][NH:12][C:13](=O)[c:14]1[n:15][c:16]([cH:17][s:18]1)[CH2:19][O:20][CH2:21][O:22][CH2:23][CH2:24][Si:25]([CH3:26])([CH3:27])[CH3:28]>Cc1ccc(cc1)S(=O)(=O)Cl.ClCCl.O>[CH3:1][O:2][C:3](=[O:4])[C:5]([CH3:6])([CH3:7])[CH2:8][c:9]1[n:11][n:12][c:13]([o:10]1)-[c:14]1[n:15][c:16]([cH:17][s:18]1)[CH2:19][O:20][CH2:21][O:22][CH2:23][CH2:24][Si:25]([CH3:26])([CH3:27])[CH3:28]|EP3212642B1_0107
4.2.3|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[c&H0&+0&D3:4](:[n&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:7])[NH:8][NH:9][C:10](=O)[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[O:17][CH2:18][CH3:19]>O=S(Cl)Cl.ClCCCl.ClCCl>[CH3:19][CH2:18][O:17][c:14]1[cH:15][cH:16][c:11]([cH:12][cH:13]1)-[c:10]1[n:9][n:8][c:6]([o:7]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1]|EP0608858A1_0062
4.2.16|[C:9]-[C&H1&+0&D3:8](-[C&H2&+0&D2:7]-O)-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[o&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH2:6]O)[NH:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][c:14]([cH:15]1)[Cl:16]>ClCCl.ClC(Cl)(Cl)Br.C1CN=C2CCCCCN2C1>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][o:9][c:8]([n:7]1)-[c:10]1[cH:11][cH:12][cH:13][c:14]([cH:15]1)[Cl:16]|US20080153850A1_0484
4.2.16|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][C:7](=O)[CH2:8][NH:9][C:10](=[O:11])[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18](=[O:19])[O:20][CH3:21]>CC[N+](CC)(CC)S(=O)(=O)NC(=O)OC.C1CCOC1.[OH-]>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][c:7]1[cH:8][n:9][c:10]([o:11]1)-[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[C:18](=[O:19])[O:20][CH3:21]|US20200392144A1_0321
4.2.2|[C:9]-[C&H0&+0&D3:8](-[O&H0&+0&D2:7]-[N&H0&+0&D2:6]=[C&H0&+0&D3:5](-[N&H2&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C@@H:2]([OH:3])[C:4](=O)[O:5][N:6]=[C:7]([NH2:8])[c:9]1[cH:10][cH:11][cH:12][c:13]([cH:14]1)[Cl:15]>O.[Na+].CC([O-])=O.CCO>[CH3:1][C@@H:2]([OH:3])[c:4]1[n:8][c:7]([n:6][o:5]1)-[c:9]1[cH:14][c:13]([cH:12][cH:11][cH:10]1)[Cl:15]|US20070293515A1_0143
4.1.61|[C&H3&D1:8]-[N&H1&+0&D2:7]-[N&H2&+0&D1:6].[C:5]-[C&H0&+0&D3:4](-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[O&H0&+0&D2:1]-C)=O)=O>>[C&H3&D1:8]-[n&H0&+0&D3:7]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:4](-[C:5]):[c&H1&+0&D2:3]:[c&H0&+0&D3:2]:1-[O&H1&+0&D1:1]|[CH3:1][NH:2][NH2:3].C[O:4][C:5](=O)[CH2:6][C:7](=O)[CH2:8][N:9]1[C:10]([c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[C:17]1=[O:18])=[O:19]>CCO>[CH3:1][n:2]1[n:3][c:7]([cH:6][c:5]1[OH:4])[CH2:8][N:9]1[C:17]([c:16]2[cH:15][cH:14][cH:13][cH:12][c:11]2[C:10]1=[O:19])=[O:18]|US20190345155A1_0227
4.2.3|[C:9]-[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[n:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[n&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][O:2][c:3]1[c:4]([n:5][c:6]([n:7]([c:8]1=[O:9])[CH3:10])[C@@H:11]1[CH2:12][CH2:13][CH2:14][N:15]1[C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[C:23](=[O:24])[NH:25][NH:26][C:27](=O)[CH2:28][c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[F:35]>>[CH3:1][O:2][c:3]1[c:8]([n:7]([c:6]([n:5][c:4]1-[c:23]1[n:25][n:26][c:27]([o:24]1)[CH2:28][c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[F:35])[C@@H:11]1[CH2:12][CH2:13][CH2:14][N:15]1[C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH3:10])=[O:9]|US10358435B2_0323
4.2.16|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[n:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][O:2][c:3]1[n:4][c:5]([n:6][c:7]([c:8]1[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=[O:18])[NH:19][CH2:20][C:21](=O)[CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29])[C:30]([CH3:31])([CH3:32])[NH:33][C:34](=[O:35])[O:36][CH2:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1>>[CH3:31][C:30]([CH3:32])([NH:33][C:34](=[O:35])[O:36][CH2:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1)[c:5]1[n:4][c:3]([c:8]([c:7]([n:6]1)-[c:17]1[n:19][cH:20][c:21]([o:18]1)[CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29])[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[O:2][CH3:1]|US20080200501A1_0588
4.2.2|[N&H1&+0&D1:8]=[C&H0&+0&D3:7](-[N&H1&+0&D2:6]-[O&H1&+0&D1:5])-[c&H0&+0&D3:4](:[c:3]):[c:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:8]1:[c&H0&+0&D3:7](:[n&H0&+0&D2:6]:[o&H0&+0&D2:5]:[c&H1&+0&D2:1]:1)-[c&H0&+0&D3:4](:[c:3]):[c:2]|[CH3:1][CH:2]([CH3:3])[n:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[n:11]([c:12]1=[O:13])[CH2:14][c:15]1[n:16][c:17]2[cH:18][c:19]([cH:20][cH:21][c:22]2[n:23]1[CH2:24][CH2:25][CH:26]([CH3:27])[CH3:28])[C:29](=[NH:30])[NH:31][OH:32].CO[CH:33](OC)OC>CCOCC.FB(F)F>[CH3:1][CH:2]([CH3:3])[n:4]1[c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[n:11]([c:12]1=[O:13])[CH2:14][c:15]1[n:16][c:17]2[cH:18][c:19]([cH:20][cH:21][c:22]2[n:23]1[CH2:24][CH2:25][CH:26]([CH3:27])[CH3:28])-[c:29]1[n:30][cH:33][o:32][n:31]1|US20200299282A1_0354
4.2.3|[N:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[N:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[c&H0&+0&D3:4](:[n&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([NH:7][C:8](=[O:9])[NH:10][NH:11][C:12](=O)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[CH:19]([CH3:20])[CH3:21]>O=P(Cl)(Cl)Cl.ClCCCl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([NH:7][c:8]1[n:10][n:11][c:12]([o:9]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[CH:19]([CH3:20])[CH3:21]|US20070293544A1_0382
4.2.3|[N&H2&+0&D1:8]-[N&H1&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c&H0&+0&D3:4](:[c:3]):[n:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:6](:[o&H0&+0&D2:5]:[c&H1&+0&D2:1]:1)-[c&H0&+0&D3:4](:[c:3]):[n:2]|CO[CH:1](OC)OC.[NH2:2][NH:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([cH:9][cH:10][n:11]1)[O:12][c:13]1[cH:14][cH:15][c:16]2[n:17][c:18]([o:19][c:20]2[cH:21]1)[NH:22][CH2:23][CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1>Cl>[cH:1]1[n:2][n:3][c:4]([o:5]1)-[c:6]1[cH:7][c:8]([cH:9][cH:10][n:11]1)[O:12][c:13]1[cH:14][cH:15][c:16]2[n:17][c:18]([o:19][c:20]2[cH:21]1)[NH:22][CH2:23][CH:24]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1|US20200172539A1_0485
4.2.2|[C:9]-[C&H0&+0&D3:8](-[O&H0&+0&D2:7]-[N&H0&+0&D2:6]=[C&H0&+0&D3:5](-[N&H2&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[n:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][c:2]1[cH:3][nH:4][c:5]([cH:6]1)[C:7]([NH2:8])=[N:9][O:10][C:11](=O)[C@@H:12]1[CH2:13][CH2:14][C@H:15]2[CH2:16][CH2:17][c:18]3[cH:19][cH:20][cH:21][cH:22][c:23]3[C:24]([N:25]2[CH2:26]1)=[O:27]>CCCC[N+](CCCC)(CCCC)CCCC.C1CCOC1.[F-]>[CH3:1][c:2]1[cH:3][nH:4][c:5]([cH:6]1)-[c:7]1[n:8][c:11]([o:10][n:9]1)[C@H:12]1[CH2:26][N:25]2[C:24]([c:23]3[cH:22][cH:21][cH:20][cH:19][c:18]3[CH2:17][CH2:16][C@@H:15]2[CH2:14][CH2:13]1)=[O:27]|EP3004094B1_0319
4.2.2|[C:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[N&H0&+0&D2:6]-[O&H0&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]([NH2:7])=[N:8][O:9][C:10](=O)[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[N+:17]([O-:18])=[O:19]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[n:7][c:10]([o:9][n:8]1)-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[N+:17]([O-:18])=[O:19]|US10654821B2_0338
4.2.3|[C:9]-[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[n&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])[C:11](=[O:12])[NH:13][NH:14][C:15](=O)[C:16]([CH3:17])([CH3:18])[CH3:19]>O=P12OP3(OP(O2)(OP(O1)(O3)=O)=O)=O.Cc1ccccc1.O.O>[CH3:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])-[c:11]1[n:13][n:14][c:15]([o:12]1)[C:16]([CH3:17])([CH3:18])[CH3:19]|EP2694513B1_0218
4.2.2|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[N&H0&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[n&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH2:11][CH2:12][C@@H:13]1[C:14](=[O:15])[NH:16][C:17](=[N:18]O)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[O:25][CH3:26]>>[CH3:26][O:25][c:22]1[cH:21][cH:20][c:19]([cH:24][cH:23]1)-[c:17]1[n:16][c:14]([o:15][n:18]1)[C@H:13]1[CH2:12][CH2:11][CH2:10][CH2:9][N:8]1[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US10118930B2_3187
4.2.3|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[c&H0&+0&D3:4](:[n&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[O:1]=[C:2]([CH2:3][N:4]1[C:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[C:12]1=[O:13])=[O:14])[NH:15][NH:16][C:17](=O)[c:18]1[n:19][cH:20][n:21]2[c:22]1[C@@H:23]1[CH2:24][CH2:25][CH2:26][N:27]1[C:28]([c:29]1[s:30][cH:31][cH:32][c:33]1-2)=[O:34]>O.O.O=C(O[Na])O[Na].O=P(O)(O)O>[O:13]=[C:12]1[c:11]2[cH:10][cH:9][cH:8][cH:7][c:6]2[C:5]([N:4]1[CH2:3][c:2]1[n:15][n:16][c:17]([o:1]1)-[c:18]1[n:19][cH:20][n:21]2-[c:33]3[cH:32][cH:31][s:30][c:29]3[C:28]([N:27]3[CH2:26][CH2:25][CH2:24][C@H:23]3[c:22]12)=[O:34])=[O:14]|EP2670245B1_0449
4.3.8|[N:9]-[C&H0&+0&D3:8](=[S&H0&+0&D1:7])-[N&H1&+0&D2:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[N:9]-[c&H0&+0&D3:8]1:[s&H0&+0&D2:7]:[c&H0&+0&D3:4](:[n&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|O=[C:1]([NH:2][NH:3][C:4](=[S:5])[NH:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[Br:19]>O.CCO.O=S(=O)(O)O>[Br:19][c:18]1[cH:17][cH:16][cH:15][cH:14][c:13]1-[c:1]1[n:2][n:3][c:4]([s:5]1)[NH:6][c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1|US20070197577A1_0554
4.1.24|[C:9]-[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[c:4])=O.[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#11]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:1]:[n&H0&+0&D2:2]:[n&H0&+0&D2:3]:[n&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|O=[C:1]([NH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][CH2:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[CH:17]1[CH2:18][CH2:19]1.[N-:20]=[N+:21]=[N:22][Na]>O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F.[O-]C(=O)O.CC#N.[Na+]>[cH:14]1[cH:13][cH:12][c:11]([cH:16][cH:15]1)[CH2:10][O:9][c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)-[n:2]1[n:20][n:21][n:22][c:1]1[CH:17]1[CH2:18][CH2:19]1|US20020052504A1_0179
4.1.8|[C:9]-[C&H1&+0&D3:8](-[C&H1&+0&D2:7]=O)-[C&H1&+0&D2:6]=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H1&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|Cl.[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH:7]=O)[CH:8]=O.[NH2:9][NH:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]>CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:8][n:9][n:10]([cH:7]1)-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]|US20200247790A1_1806
4.2.3|[N&H2&+0&D1:8]-[N&H1&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-[c&H0&+0&D3:4](:[c:3]):[c:2].[C&H1&+0&D3:1](-O-C)(-O-C)-O-C>>[n&H0&+0&D2:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:6](:[o&H0&+0&D2:5]:[c&H1&+0&D2:1]:1)-[c&H0&+0&D3:4](:[c:3]):[c:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1([CH2:7][CH2:8][C:9]([N:10]1[c:11]1[cH:12][cH:13][c:14]([n:15][cH:16]1)[O:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[C:24](=[O:25])[NH:26][NH2:27])=[O:28])[C:29](=[O:30])[O:31][CH2:32][CH3:33].CO[CH:34](OC)OC>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6]1([CH2:7][CH2:8][C:9]([N:10]1[c:11]1[cH:16][n:15][c:14]([cH:13][cH:12]1)[O:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)-[c:24]1[n:26][n:27][cH:34][o:25]1)=[O:28])[C:29](=[O:30])[O:31][CH2:32][CH3:33]|US20200087304A1_0543
4.2.16|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[c&H0&+0&D3:4](:[c&H1&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|O=[C:1]([CH2:2][NH:3][C:4](=[O:5])[CH2:6][Cl:7])[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>O.O=P(O)(O)O>[Cl:7][CH2:6][c:4]1[n:3][cH:2][c:1]([o:5]1)-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1|US20130158075A1_1485
4.1.12|[N&H4&+&D0:9].[C:8]-[C&H0&+0&D3:7](-[N&H1&+0&D2:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)=O>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:4](:[c&H1&+0&D2:5]:[n&H1&+0&D2:6]:[c&H0&+0&D3:7]:1-[C:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH4+:1].CC([O-])=O.[O:2]=[C:3]([NH:4][CH2:5][CH:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[C:12](=O)[NH:13][CH2:14][C:15](=O)[c:16]1[cH:17][cH:18][cH:19][c:20]([cH:21]1)[C:22]([F:23])([F:24])[F:25])[O:26][CH2:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>CC(=O)O>[O:2]=[C:3]([NH:4][CH2:5][CH:6]1[CH2:7][CH2:8][CH:9]([CH2:10][CH2:11]1)[c:12]1[n:1][c:15]([cH:14][nH:13]1)-[c:16]1[cH:17][cH:18][cH:19][c:20]([cH:21]1)[C:22]([F:23])([F:24])[F:25])[O:26][CH2:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1|EP2148880B1_0087
4.3.11|[C:9]-[C&H0&+0&D4:8](-[C:7])(-[C&H0&+0&D3:6](=[O&H0&D1:5])-O-C)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:9]-[C&H0&+0&D4:8]1(-[C:7])-[S&H0&+0&D2:1]-[C&H0&+0&D3:3](=[N&H0&+0&D2:4]-[C&H0&+0&D3:6]-1=[O&H0&D1:5])-[N:2]|CO[C:1](=[O:2])[C:3]1([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1)Br.[NH2:9][C:10](=[S:11])[NH:12][CH:13]1[CH2:14][CH:15]2[CH2:16][CH2:17][CH:18]1[CH2:19]2>>[O:2]=[C:1]1[N:9]=[C:10]([S:11][C:3]11[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)[NH:12][CH:13]1[CH2:14][CH:15]2[CH2:16][CH2:17][CH:18]1[CH2:19]2|US07253196B2_0978
4.1.14|[N&H4&+&D0:9].[C:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[n:2]):[s:1])=O)=O>>[n&H1&+0&D2:9]1:[c&H0&+0&D3:4](:[c&H1&+0&D2:5]:[c&H1&+0&D2:6]:[c&H0&+0&D3:7]:1-[C:8])-[c&H0&+0&D3:3](:[n:2]):[s:1]|[NH4+:1].[CH3:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH:12]([CH2:13][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1)[C:19](=O)[CH2:20][CH2:21][C:22](=O)[c:23]1[n:24][cH:25][cH:26][s:27]1.CC([O-])=O>CCOC(C)=O.CN(C)C=O>[CH3:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[CH:12]([CH2:13][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1)[c:19]1[cH:20][cH:21][c:22]([nH:1]1)-[c:23]1[n:24][cH:25][cH:26][s:27]1|EP2149550A1_1292
4.1.14|[N&H4&+&D0:9].[C:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])=O)=O>>[n&H1&+0&D2:9]1:[c&H0&+0&D3:4](:[c&H1&+0&D2:5]:[c&H1&+0&D2:6]:[c&H0&+0&D3:7]:1-[C:8])-[c&H0&+0&D3:3](:[c:2]):[n:1]|[NH4+:1].CC([O-])=O.O=[C:2]([CH2:3][CH2:4][C:5](=O)[CH:6]([CH2:7][CH:8]1[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1)[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[S:20](=[O:21])(=[O:22])[CH:23]1[CH2:24][CH2:25]1)[c:26]1[cH:27][cH:28][cH:29][cH:30][n:31]1>CCOC(C)=O.CN(C)C=O>[O:21]=[S:20](=[O:22])([c:17]1[cH:18][cH:19][c:14]([cH:15][cH:16]1)[CH:6]([CH2:7][CH:8]1[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1)[c:5]1[cH:4][cH:3][c:2]([nH:1]1)-[c:26]1[cH:27][cH:28][cH:29][cH:30][n:31]1)[CH:23]1[CH2:24][CH2:25]1|EP2149550A1_1478
4.3.13|[C:8]-[C&H1&+0&D3:7](-[C&H0&+0&D3:6](=[O&H0&D1:5])-O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[S&H0&+0&D1:1]>>[C:8]-[C&H1&+0&D3:7]1-[S&H0&+0&D2:1]-[C&H0&+0&D3:3](=[N&H1&+0&D1:4])-[N&H1&+0&D2:2]-[C&H0&+0&D3:6]-1=[O&H0&D1:5]|[NH2:1][C:2]([NH2:3])=[S:4].[O:5]=[C:6](O)[CH:7](Br)[CH2:8][CH2:9][O:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O.[Na+].COCCO.CC([O-])=O.ClCCl>[NH:3]=[C:2]1[NH:1][C:6]([CH:7]([S:4]1)[CH2:8][CH2:9][O:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)=[O:5]|US05693651A
4.1.80|[C:9]/[N&H0&+0&D2:8]=[C&H1&+0&D2:7]/[C:6].[C&H1&+0&D2:5]1=[C&H1&+0&D2:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]-1>>[C:9]-[N&H0&+0&D3:8]1-[C@&H1&+0&D3:2]2-[C&H1&+0&D2:3]=[C&H1&+0&D2:4]-[C@@&H1&+0&D3:5](-[C@@&H1&+0&D3:7]-1-[C:6])-[C:1]-2|[CH3:1][C@@H:2](/[N:3]=[CH:4]/[C:5](=[O:6])[O:7][CH2:8][CH3:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[CH:16]1[CH:17]=[CH:18][CH2:19][CH:20]=1>>[CH3:9][CH2:8][O:7][C:5](=[O:6])[C@@H:4]1[C@H:18]2[CH:17]=[CH:16][C@H:20]([CH2:19]2)[N:3]1[C@H:2]([CH3:1])[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US10815241B2_0780
4.1.62|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[O&H0&+0&D2:5]-C)=O)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:1)=[O&H0&+0&D1:5]|[CH3:1][CH2:2][CH2:3][C:4](=O)[CH2:5][C:6](=O)[O:7]C.[CH3:8][c:9]1[cH:10][cH:11][cH:12][n:13][c:14]1[NH2:15]>COCCO.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][CH2:2][CH2:3][c:4]1[cH:5][c:6]([n:13]2[cH:12][cH:11][cH:10][c:9]([c:14]2[n:15]1)[CH3:8])=[O:7]|US10280165B2_0319
4.1.62|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[O&H0&+0&D2:5]-C)=O)=O.[N&H2&+0&D1:4]-[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[n:1]):[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:1)-[O&H1&+0&D1:5]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH2:11][CH2:12][CH2:13]1)[C:14](=O)[CH2:15][C:16](=O)[O:17]C.[NH2:18][c:19]1[cH:20][cH:21][n:22][nH:23]1>>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:9]1)[c:14]1[cH:15][c:16]([n:23]2[n:22][cH:21][cH:20][c:19]2[n:18]1)[OH:17]|US20180282338A1_0368
4.2.3|[C:9]-[C&H0&+0&D3:8](=O)-O.[N&H2&+0&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[o&H0&+0&D2:4]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|O=[C:1](O)[C:2]12[CH2:3][CH2:4][C:5]([CH2:6][CH2:7]1)([CH2:8][CH2:9]2)[c:10]1[n:11][c:12]([n:13][o:14]1)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21].[NH2:22][NH:23][C:24](=[O:25])[c:26]1[cH:27][cH:28][cH:29][cH:30][c:31]1[C:32]([F:33])([F:34])[F:35]>CN1CC[N+](=C1Cl)C.Cc1ccccc1.CCN(CC)CC.ClCCl.[Cl-]>[F:33][C:32]([F:34])([F:35])[c:31]1[cH:30][cH:29][cH:28][cH:27][c:26]1-[c:24]1[n:23][n:22][c:1]([o:25]1)[C:2]12[CH2:3][CH2:4][C:5]([CH2:8][CH2:9]1)([CH2:6][CH2:7]2)[c:10]1[n:11][c:12]([n:13][o:14]1)-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21]|US10584117B2_0166
4.2.2|[C:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[N&H0&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][N:3]=[C:4]1[CH2:5][C@H:6]([N:7]([CH2:8]1)[C:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[C:23]([NH2:24])=[N:25]O.[O:26]=[C:27](O)[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>>[CH3:1][O:2][N:3]=[C:4]1[CH2:8][N:7]([C@@H:6]([CH2:5]1)[c:23]1[n:24][c:27]([o:26][n:25]1)-[c:28]1[cH:33][cH:32][cH:31][cH:30][cH:29]1)[C:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US09000175B2_0543
4.2.4|[C:9]-[C&H0&+0&D3:8](=[C&H1&+0&D2:7]-[N&H0&+0&D3:6](-C)-C)-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[n&H0&+0&D2:6]:[o&H0&+0&D2:4]:[c&H0&+0&D3:5]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|C[N:1](C)[CH:2]=[C:3]([C:4](=[O:5])[O:6][CH2:7][CH3:8])[C:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[C:17]([F:18])([F:19])[F:20]>CCOC(=O)C(=CN(C)C)C(=O)c1ccc(cc1Cl)Cl>[CH3:8][CH2:7][O:6][C:4](=[O:5])[c:3]1[cH:2][n:1][o:10][c:9]1-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[C:17]([F:18])([F:19])[F:20]|US20050288273A1_1206
4.2.2|[C:9]-[C&H0&+0&D3:8](=[N&H1&+0&D1:7])-[N&H1&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])-O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][c:2]1[n:3][cH:4][c:5]2[CH2:6][c:7]3[c:8]([n:9][cH:10][n:11][c:12]3-[c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3-[n:19]12)[C:20](=[O:21])O.[NH:22]=[C:23]([NH:24]O)[CH:25]1[CH2:26][CH2:27]1>CC(=O)O.CN(C)C=O.O=C(n1ccnc1)n1ccnc1>[CH3:1][c:2]1[n:3][cH:4][c:5]2[CH2:6][c:7]3[c:12]([n:11][cH:10][n:9][c:8]3-[c:20]3[n:22][c:23]([n:24][o:21]3)[CH:25]3[CH2:26][CH2:27]3)-[c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3-[n:19]12|US20090170907A1_0949
4.1.9|[C&H3&D1:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[N&H1&+0&D2:4]-[c:3]:[c&H1&+0&D2:2]:[c:1])=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[c&H0&+0&D3:6](=[O&H0&D1:5]):[n&H1&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][C:2](=O)[CH2:3][C:4](=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[Br:13]>O.O.O.CCOC(C)=O.O=S(=O)(O)O>[CH3:1][c:2]1[cH:3][c:4]([nH:6][c:7]2[cH:8][cH:9][c:10]([cH:11][c:12]12)[Br:13])=[O:5]|US20170291875A1_0545
4.2.2|[N&H2&+0&D1:9]-[C&H0&+0&D3:8](-[N:7])=[N&H0&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[N:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][C:2](=[N:3]O)[N:4]1[CH2:5][CH2:6][CH:7]([CH2:8][CH2:9]1)[O:10][c:11]1[cH:12][c:13]([cH:14][cH:15][c:16]1[Br:17])[F:18].[O:19]=[C:20](O)[c:21]1[cH:22][cH:23][nH:24][cH:25]1.O>CCN(CC)CC.CN(C)C=O.C1CCOC1.C(C#[O+])#[O+].[Cl-].[Cl-].[NaH]>[F:18][c:13]1[cH:14][cH:15][c:16]([c:11]([cH:12]1)[O:10][CH:7]1[CH2:6][CH2:5][N:4]([CH2:9][CH2:8]1)[c:2]1[n:1][c:20]([o:19][n:3]1)-[c:21]1[cH:22][cH:23][nH:24][cH:25]1)[Br:17]|US20150051206A1_0489
4.2.2|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[N&H0&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][C:2](=[N:3]O)[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[O:10]=[C:11](O)[C:12]([Cl:13])([Cl:14])[Cl:15]>O=C(OC(=O)C(Cl)(Cl)Cl)C(Cl)(Cl)Cl.O.O>[Cl:13][C:12]([Cl:14])([Cl:15])[c:11]1[n:1][c:2]([n:3][o:10]1)-[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1|US20110275673A1_0698
4.1.8|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:5](:[c:4]):[c:3]|O.[NH2:1][NH2:2].[O:3]=[C:4]([OH:5])[C:6]1[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=1[C:12](=O)[CH2:13][C:14](=O)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O.Cl.CO.[Na][Na]>[O:3]=[C:4]([OH:5])[C:6]1[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=1[c:12]1[cH:13][c:14]([nH:2][n:1]1)-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|EP2848615A1_0091
4.2.2|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-O.[N&H1&+0&D1:6]=[C&H0&+0&D3:5](-[N&H1&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][CH2:10][c:11]1[c:12]([nH:13][c:14]2[cH:15][cH:16][c:17]([cH:18][c:19]12)[C:20](=[NH:21])[NH:22]O)-[c:23]1[cH:24][c:25]([cH:26][c:27]([cH:28]1)[CH3:29])[CH3:30].[CH3:31][CH:32]([CH3:33])[CH2:34][C:35](=[O:36])O>CCN=C=NCCCN(C)C.On1nnc2ccccc21.Cl>[CH3:29][c:27]1[cH:26][c:25]([cH:24][c:23]([cH:28]1)-[c:12]1[nH:13][c:14]2[cH:15][cH:16][c:17]([cH:18][c:19]2[c:11]1[CH2:10][CH2:9][NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])-[c:20]1[n:21][c:35]([o:36][n:22]1)[CH2:34][CH:32]([CH3:31])[CH3:33])[CH3:30]|US08420655B2_0478
4.2.3|[C:9]-[C&H0&+0&D3:8](-O)=O.[N&H2&+0&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[o&H0&+0&D2:4]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8][cH:9][n:10]2[CH2:11][C:12](=O)O)[c:13]1[C:14]([F:15])([F:16])[F:17].[NH2:18][NH:19][C:20](=[O:21])[c:22]1[cH:23][cH:24][cH:25][cH:26][n:27]1>>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8][cH:9][n:10]2[CH2:11][c:12]2[n:18][n:19][c:20]([o:21]2)-[c:22]2[cH:23][cH:24][cH:25][cH:26][n:27]2)[c:13]1[C:14]([F:15])([F:16])[F:17]|US10538498B2_1467
4.2.3|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-O)=O>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[c&H0&+0&D3:1](:[n&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|O=[C:1](O)[c:2]1[cH:3][n:4][cH:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11].[NH2:12][NH:13][C:14](=[O:15])[CH2:16][c:17]1[cH:18][cH:19][s:20][cH:21]1>O=P(Cl)(Cl)Cl.N.O.O>[F:9][C:8]([F:10])([F:11])[c:7]1[cH:6][cH:5][n:4][cH:3][c:2]1-[c:1]1[n:12][n:13][c:14]([o:15]1)[CH2:16][c:17]1[cH:18][cH:19][s:20][cH:21]1|US10544113B2_0548
4.2.2|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-O.[N&H1&+0&D1:6]=[C&H0&+0&D3:5](-[N&H1&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8][c:9]([n:10]2[CH2:11][C:12](=[O:13])O)[CH:14]([F:15])[F:16])[c:17]1[Cl:18].[NH:19]=[C:20]([NH:21]O)[c:22]1[cH:23][cH:24][cH:25][cH:26][n:27]1>Cl.CCN=C=NCCCN(C)C.ClCCCl>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8][c:9]([n:10]2[CH2:11][c:12]2[n:19][c:20]([n:21][o:13]2)-[c:22]2[cH:23][cH:24][cH:25][cH:26][n:27]2)[CH:14]([F:15])[F:16])[c:17]1[Cl:18]|US20200339559A1_0530
3.11.3|[C&H2&+0&D1:8]=[C&H1&+0&D2:7]-[C:6].[c&H1&+0&D2:5]1:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c&H1&+0&D2:2]:[o&H0&+0&D2:1]:1>>[C&H2&+0&D2:8]1-[C&H1&+0&D3:7](-[C:6])-[C&H1&+0&D3:2]2-[C&H1&+0&D2:3]=[C&H1&+0&D2:4]-[C&H1&+0&D3:5]-1-[O&H0&+0&D2:1]-2|[CH2:1]=[CH:2][C:3](=[O:4])[O:5][CH2:6][CH2:7][CH2:8][CH3:9].[cH:10]1[cH:11][cH:12][o:13][cH:14]1>Cl[Sn](Cl)(Cl)Cl.O>[CH3:9][CH2:8][CH2:7][CH2:6][O:5][C:3](=[O:4])[CH:2]1[CH2:1][CH:14]2[CH:10]=[CH:11][CH:12]1[O:13]2|US20080154043A1_0012
4.2.2|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[N&H0&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[NH2:1][C:2](=[N:3]O)[c:4]1[n:5][cH:6][n:7]2-[c:8]3[cH:9][cH:10][cH:11][c:12]([c:13]3[C:14]([N:15]3[CH2:16][CH2:17][CH2:18][C@H:19]3[c:20]12)=[O:21])[Cl:22].[O:23]=[C:24](O)[CH:25]1[CH2:26][CH2:27]1>CN(C)C=O.O=C(n1ccnc1)n1ccnc1>[O:21]=[C:14]1[c:13]2[c:12]([cH:11][cH:10][cH:9][c:8]2-[n:7]2[cH:6][n:5][c:4]([c:20]2[C@@H:19]2[CH2:18][CH2:17][CH2:16][N:15]12)-[c:2]1[n:1][c:24]([o:23][n:3]1)[CH:25]1[CH2:26][CH2:27]1)[Cl:22]|US20090286791A1_0861
4.1.8|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:5](:[c:4]):[c:3]|O.[CH3:1][CH2:2][O:3][CH:4]([O:5][CH2:6][CH3:7])[C:8](=O)[CH2:9][C:10](=O)[c:11]1[cH:12][c:13]([c:14]([cH:15][c:16]1[F:17])[Cl:18])[O:19][CH:20]([CH3:21])[CH3:22].[NH2:23][NH2:24]>CCO>[CH3:7][CH2:6][O:5][CH:4]([O:3][CH2:2][CH3:1])[c:8]1[cH:9][c:10]([n:23][nH:24]1)-[c:11]1[cH:12][c:13]([c:14]([cH:15][c:16]1[F:17])[Cl:18])[O:19][CH:20]([CH3:21])[CH3:22]|US20200031781A1_0362
4.1.111|[C:10]-[N&H1&+0&D2:9]-[C:8]-[N&H1&+0&D2:7]-[c:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[C:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O)-O>>[C:10]-[N&H0&+0&D3:9]1-[C:8]-[N&H0&+0&D3:7](-[c:6])-[C&H0&+0&D3:4](=[O&H0&D1:5])-[C:3]-[C&H0&+0&D3:2]-1=[O&H0&D1:1]|[O:1]=[C:2]([NH:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[S:10](=[O:11])(=[O:12])[F:13])[NH:14][CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1.[O:21]=[C:22](O)[CH2:23][C:24](=[O:25])O>O.CC(=O)Cl>[O:25]=[C:24]1[CH2:23][C:22]([N:3]([C:2]([N:14]1[CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]1)=[O:1])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[S:10](=[O:11])(=[O:12])[F:13])=[O:21]|US10114160B2_0308
4.2.2|[C:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[N&H0&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])-O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][CH2:2][C:3]([NH2:4])=[N:5]O.[CH3:6][c:7]1[c:8]([n:9][cH:10][c:11]2[nH:12][c:13]3[cH:14][cH:15][c:16]([cH:17][c:18]3[c:19]12)[CH:20]1[CH2:21][CH2:22][CH:23]=[CH:24][CH2:25]1)[C:26](=[O:27])O>CN(C)C=O.O=S(Cl)Cl.c1c[nH]cn1.C1CCOC1>[CH3:1][CH2:2][c:3]1[n:4][c:26]([o:27][n:5]1)-[c:8]1[n:9][cH:10][c:11]2[nH:12][c:13]3[cH:14][cH:15][c:16]([cH:17][c:18]3[c:19]2[c:7]1[CH3:6])[CH:20]1[CH2:25][CH:24]=[CH:23][CH2:22][CH2:21]1|US05371080A
4.2.2|[C:9]-[C&H0&+0&D3:8](=[N&H1&+0&D1:7])-[N&H1&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH:12]([CH2:13]1)[O:14][CH2:15][c:16]1[cH:17][cH:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[cH:25]1)[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[CH2:32][CH2:33][C:34](=[NH:35])[NH:36]O.[O:37]=[C:38](O)[c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1>ClCCCl>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:13][CH:12]([CH:11]([CH2:10][CH2:9]1)[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[CH2:32][CH2:33][c:34]1[n:35][c:38]([o:37][n:36]1)-[c:39]1[cH:44][cH:43][cH:42][cH:41][cH:40]1)[O:14][CH2:15][c:16]1[cH:17][cH:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[cH:25]1|US05070090A
4.1.8|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[n:3])=O)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:5](:[c:4]):[n:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[C:14](=O)[CH2:15][C:16](=O)[c:17]1[cH:18][cH:19][cH:20][cH:21][n:22]1.[NH2:23][NH2:24].O>CCO>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:12][CH2:13]1)[c:14]1[cH:15][c:16]([n:23][nH:24]1)-[c:17]1[cH:18][cH:19][cH:20][cH:21][n:22]1|US09260395B2_0487
4.1.12|[C:9]-[C&H0&+0&D3:8](=[N&H1&+0&D1:7])-[N&H2&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](:[n&H1&+0&D2:6]:1)-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][CH:2]([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[C:12](=[O:13])[NH:14][CH:15]([CH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[C:23](=O)[CH2:24]Br)[C:25](=[O:26])[NH:27][CH3:28].[CH3:29][C:30]([CH3:31])([CH3:32])[C:33](=[NH:34])[NH2:35]>O=C(O[K])O[K].Cl>[CH3:28][NH:27][C:25](=[O:26])[CH:15]([CH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)-[c:23]1[cH:24][n:34][c:33]([nH:35]1)[C:30]([CH3:29])([CH3:31])[CH3:32])[NH:14][C:12](=[O:13])[c:8]1[cH:7][cH:6][c:5]([c:10]([cH:9]1)[Cl:11])[O:4][CH:2]([CH3:1])[CH3:3]|US09199999B2_0371
4.3.3|[C:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[S&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:1)-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]([NH2:8])=[S:9].O=[C:10]([CH2:11]Br)[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Br:18]>CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[n:8][c:10]([cH:11][s:9]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Br:18]|US20090192203A1_0246
4.3.3|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-Cl)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[s&H0&+0&D2:4]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=O)[CH2:8]Cl.[NH2:9][C:10](=[S:11])[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[Br:18]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][s:11][c:10]([n:9]1)-[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[Br:18]|US20190345119A1_0448
4.1.12|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-Br)=O.[N&H1&+0&D1:6]=[C&H0&+0&D3:5](-[N&H2&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H1&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH:1]=[C:2]([NH2:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Br:10].O=[C:11]([CH2:12]Br)[C@@H:13]1[CH2:14][CH2:15][CH2:16][N:17]1[C:18](=[O:19])[O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>O=C(O)O[Na].C1CCOC1>[O:19]=[C:18]([O:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[N:17]1[CH2:16][CH2:15][CH2:14][C@H:13]1[c:11]1[cH:12][n:1][c:2]([nH:3]1)-[c:4]1[cH:9][cH:8][c:7]([cH:6][cH:5]1)[Br:10]|US20200115381A1_0862
4.1.12|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-Br)=O.[N&H1&+0&D1:6]=[C&H0&+0&D3:5](-[N&H2&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H1&+0&D2:6]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH:1]=[C:2]([NH2:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[O:10]=[C:11]1[c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[C:18]([N:19]1[CH2:20][CH2:21][CH2:22][C:23](=O)[CH2:24]Br)=[O:25]>CN(C)C=O.O=C(O[K])O[K]>[O:25]=[C:18]1[c:17]2[cH:16][cH:15][cH:14][cH:13][c:12]2[C:11]([N:19]1[CH2:20][CH2:21][CH2:22][c:23]1[cH:24][nH:1][c:2]([n:3]1)-[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)=[O:10]|US20090286827A1_0202
4.3.3|[C:9]-[C&H1&+0&D3:8](-[C&H1&+0&D2:7]=O)-Cl.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[s&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Cl)[CH:7]=O.[NH2:8][C:9](=[S:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]>CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([s:10]1)-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]|US20200347053A1_0724
4.2.2|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-Cl.[N&H2&+0&D1:6]/[C&H0&+0&D3:5](=[N&H0&+0&D2:4]\O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[O:7])Cl.[CH3:8][n:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[c:16]2[c:17]1[cH:18][cH:19][c:20]([n:21]2-[c:22]1[cH:23][cH:24][c:25]([cH:26][cH:27]1)[C:28](/[NH2:29])=[N:30]/O)=[O:31]>>[CH3:8][n:9]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[c:16]2[c:17]1[cH:18][cH:19][c:20]([n:21]2-[c:22]1[cH:27][cH:26][c:25]([cH:24][cH:23]1)-[c:28]1[n:29][c:6]([o:7][n:30]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1])=[O:31]|US20200231556A1_0329
4.2.3|[C:9]-[C&H0&+0&D3:8](-Cl)=O.[N&H2&+0&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[o&H0&+0&D2:4]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][NH:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[OH:11].[CH3:12][C:13](=[O:14])[O:15][CH2:16][C:17](=O)Cl>c1ccc(cc1)P(c1ccccc1)c1ccccc1.CCN(CC)CC.BrC(Br)(Br)Br.C1CCOC1.CC#N>[CH3:12][C:13](=[O:14])[O:15][CH2:16][c:17]1[n:1][n:2][c:3]([o:4]1)-[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[OH:11]|US20200093852A1_0463
4.3.3|[N&H2&+0&D1:9]-[C&H0&+0&D3:8](-[N:7])=[S&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[o:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[N:7])-[c&H0&+0&D3:4](:[c:5]):[o:3]|[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([o:10]1)[C:11](=O)[CH2:12]Br.[NH:13]=[C:14]([NH2:15])[NH:16][C:17]([NH2:18])=[S:19]>CC(C)=O.O[Na]>[CH3:1][N:2]([CH3:3])[C:4](=[O:5])[c:6]1[cH:7][cH:8][c:9]([o:10]1)-[c:11]1[cH:12][s:19][c:17]([n:18]1)[NH:16][C:14](=[NH:13])[NH2:15]|US20140329863A1_0741
4.2.2|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-Cl.[N&H1&+0&D1:6]=[C&H0&+0&D3:5](-[N&H1&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][C:3](=[O:4])Cl.[NH:5]=[C:6]([NH:7]O)[c:8]1[cH:9][c:10]([c:11]([c:12]([cH:13]1)[Cl:14])[OH:15])[Cl:16]>c1ccncc1>[CH3:1][CH2:2][c:3]1[n:5][c:6]([n:7][o:4]1)-[c:8]1[cH:13][c:12]([c:11]([c:10]([cH:9]1)[Cl:16])[OH:15])[Cl:14]|US20200255407A1_1031
4.2.16|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-Br)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[o&H0&+0&D2:4]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7]Br.[NH2:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[OH:17]>CCOC(C)=O.c1cocn1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][o:10][c:9]([n:8]1)-[c:11]1[cH:16][cH:15][c:14]([cH:13][cH:12]1)[OH:17]|US20160145263A1_0606
4.2.2|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-Cl.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[N&H0&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][N:2]1[CH2:3][c:4]2[c:5]([n:6][cH:7][n:8]2-[c:9]2[cH:10][cH:11][cH:12][c:13]([c:14]2[C:15]1=[O:16])[Cl:17])[C:18]([NH2:19])=[N:20]O.[O:21]=[C:22](Cl)[CH:23]1[CH2:24][CH2:25]1>C1CCOC1>[CH3:1][N:2]1[CH2:3][c:4]2[c:5]([n:6][cH:7][n:8]2-[c:9]2[cH:10][cH:11][cH:12][c:13]([c:14]2[C:15]1=[O:16])[Cl:17])-[c:18]1[n:19][c:22]([o:21][n:20]1)[CH:23]1[CH2:24][CH2:25]1|US10308659B2_0664
4.2.2|[C:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[N&H0&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Cl>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][C:2]([CH2:3][Cl:4])=[N:5]O.[O:6]=[C:7](Cl)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[Cl:14]>CC(C)=O.O=C(O)O[Na]>[Cl:14][c:11]1[cH:12][cH:13][c:8]([cH:9][cH:10]1)-[c:7]1[n:1][c:2]([n:5][o:6]1)[CH2:3][Cl:4]|US20200262828A1_0470
4.2.16|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-Cl)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[o&H0&+0&D2:4]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=O)[CH2:8]Cl.[NH2:9][C:10](=[O:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>O=C(O)O[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][o:11][c:10]([n:9]1)-[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US20080207708A1_0254
4.2.16|[C:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[O&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[o&H0&+0&D2:6]:1)-[c&H0&+0&D3:4](:[c:5]):[c:3]|O=[C:1]([CH2:2]Br)[c:3]1[cH:4][c:5]([cH:6][c:7]([cH:8]1)[C:9]([F:10])([F:11])[F:12])[C:13]([F:14])([F:15])[F:16].[CH3:17][CH2:18][O:19][C:20](=[O:21])[CH2:22][CH2:23][C:24]([NH2:25])=[O:26]>O>[CH3:17][CH2:18][O:19][C:20](=[O:21])[CH2:22][CH2:23][c:24]1[n:25][c:1]([cH:2][o:26]1)-[c:3]1[cH:8][c:7]([cH:6][c:5]([cH:4]1)[C:13]([F:14])([F:15])[F:16])[C:9]([F:10])([F:11])[F:12]|US20190218215A1_0402
4.3.3|[N&H2&+0&D1:9]-[C&H0&+0&D3:8](-[N:7])=[S&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[N:7])-[c&H0&+0&D3:4](:[c:5]):[c:3]|[NH:1]=[C:2]([NH2:3])[NH:4][C:5]([NH2:6])=[S:7].[O-:8][N+:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[C:17](=O)[CH2:18]Br>O.CN(C)C=O.O[Na]>[NH:1]=[C:2]([NH2:3])[NH:4][c:5]1[n:6][c:17]([cH:18][s:7]1)-[c:16]1[cH:15][cH:14][cH:13][cH:12][c:11]1[N+:9]([O-:8])=[O:10]|US07319104B2_1274
4.1.12|[N&H1&+0&D1:9]=[C&H0&+0&D3:8](-[N&H2&+0&D1:7])-[N:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H1&+0&D2:9]1:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](:[n&H0&+0&D2:7]:[c&H0&+0&D3:8]:1-[N:6])-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C:9](=[NH:10])[NH2:11].[CH3:12][O:13][c:14]1[cH:15][cH:16][c:17]([c:18]2[s:19][c:20]([n:21][c:22]12)[NH:23][C:24](=[O:25])[OH:26])[C:27](=O)[CH2:28]Br>CC#N>[CH3:12][O:13][c:14]1[cH:15][cH:16][c:17]([c:18]2[s:19][c:20]([n:21][c:22]12)[NH:23][C:24](=[O:25])[OH:26])-[c:27]1[cH:28][nH:10][c:9]([n:11]1)[NH:8][C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US10221163B2_0521
4.3.3|[N&H2&+0&D1:9]-[C&H0&+0&D3:8](-[N:7])=[S&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[n:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[N:7])-[c&H0&+0&D3:4](:[c:5]):[n:3]|[BrH:1].[CH3:2][c:3]1[n:4][c:5]([cH:6][nH:7]1)[C:8](=O)[CH2:9]Br.[NH:10]=[C:11]([NH2:12])[NH:13][C:14]([NH2:15])=[S:16]>O.CC(C)=O.O=C(O)O[Na]>[BrH:1].[CH3:2][c:3]1[n:4][c:5]([cH:6][nH:7]1)-[c:8]1[cH:9][s:16][c:14]([n:15]1)[NH:13][C:11](=[NH:10])[NH2:12]|US07223785B2_0936
4.2.2|[C:9]-[C&H0&+0&D3:8](=[N&H1&+0&D1:7])-[N&H1&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Cl>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=[NH:6])[NH:7]O.[O:8]=[C:9](Cl)[c:10]1[cH:11][n:12][c:13]([c:14]([cH:15]1)[Cl:16])[Cl:17]>Cc1ccccc1>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[n:6][c:9]([o:8][n:7]1)-[c:10]1[cH:11][n:12][c:13]([c:14]([cH:15]1)[Cl:16])[Cl:17]|US20080113995A1_0221
4.3.3|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-Br)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[s&H0&+0&D2:4]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7]Br.[NH2:8][C:9](=[S:10])[c:11]1[n:12][cH:13][cH:14][cH:15][c:16]1[OH:17]>CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][s:10][c:9]([n:8]1)-[c:11]1[n:12][cH:13][cH:14][cH:15][c:16]1[OH:17]|US20200040039A1_0797
4.2.16|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-Cl)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[s:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[o&H0&+0&D2:4]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[s:1]|[NH2:1][C:2](=[O:3])[c:4]1[cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[s:12]1.O=[C:13]([CH2:14]Cl)[CH2:15][Cl:16]>>[Cl:16][CH2:15][c:13]1[cH:14][o:3][c:2]([n:1]1)-[c:4]1[cH:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]2[s:12]1|US08563577B2_0297
4.2.2|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-Cl.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[N&H0&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][C:3](=[O:4])Cl.[NH2:5][C:6](=[N:7]O)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[O:14][CH2:15][CH2:16][CH2:17][n:18]1[cH:19][cH:20][n:21][cH:22]1>O.O=C(O[K])O[K].c1ccncc1>[CH3:1][CH2:2][c:3]1[n:5][c:6]([n:7][o:4]1)-[c:8]1[cH:13][cH:12][c:11]([cH:10][cH:9]1)[O:14][CH2:15][CH2:16][CH2:17][n:18]1[cH:19][cH:20][n:21][cH:22]1|US07585881B2_1726
4.3.3|[N&H2&+0&D1:9]-[C&H0&+0&D3:8](-[N:7])=[S&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[s:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[N:7])-[c&H0&+0&D3:4](:[c:5]):[s:3]|[CH3:1][N:2]([CH:3]=[O:4])[c:5]1[n:6][c:7]([c:8]([s:9]1)[C:10](=O)[CH2:11]Br)[CH3:12].[NH:13]=[C:14]([NH2:15])[NH:16][C:17]([NH2:18])=[S:19]>CO>[CH3:1][N:2]([CH:3]=[O:4])[c:5]1[n:6][c:7]([c:8]([s:9]1)-[c:10]1[cH:11][s:19][c:17]([n:18]1)[NH:16][C:14](=[NH:13])[NH2:15])[CH3:12]|US20140329863A1_0745
4.3.3|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-Cl)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[s&H0&+0&D2:4]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=O)[CH2:8]Cl.[NH2:9][C:10](=[S:11])[c:12]1[n:13][cH:14][cH:15][cH:16][c:17]1[OH:18]>CCOC(=O)Cc1csc(n1)-c1ccccc1O.Br[Li].C1CCOC1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][s:11][c:10]([n:9]1)-[c:12]1[n:13][cH:14][cH:15][cH:16][c:17]1[OH:18]|US08957070B2_1452
4.3.3|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-Br)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[s&H0&+0&D2:4]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=O)[CH2:8]Br.[NH2:9][C:10](=[S:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>CCOCC.CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[cH:8][s:11][c:10]([n:9]1)-[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US20190345119A1_0438
4.3.3|[C:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[S&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[n:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:1)-[c&H0&+0&D3:4](:[c:5]):[n:3]|Br.[CH3:1][C:2](=[O:3])[NH:4][CH2:5][C:6]([NH2:7])=[S:8].[NH2:9][c:10]1[n:11][c:12]([cH:13][s:14]1)[C:15](=O)[CH2:16]Br>CCO>[CH3:1][C:2](=[O:3])[NH:4][CH2:5][c:6]1[n:7][c:15]([cH:16][s:8]1)-[c:12]1[cH:13][s:14][c:10]([n:11]1)[NH2:9]|US20190048019A1_0163
4.2.26|[N&H2&+0&D1:8]-[c:7]:[c:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[O&H1&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[n&H1&+0&D2:8]1:[c:7]:[c:6]:[c&H0&+0&D3:5](=[O&H0&D1:4]):[o&H0&+0&D2:3]:[c&H0&+0&D3:1]:1=[O&H0&D1:2]|[O:1]=[C:2](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[NH2:3][c:4]1[cH:5][cH:6][c:7]([cH:8][c:9]1[C:10](=[O:11])[OH:12])[Cl:13]>Nc1ccccc1C(=O)O.C1CCOC1>[O:11]=[c:10]1[o:12][c:2]([nH:3][c:4]2[cH:5][cH:6][c:7]([cH:8][c:9]21)[Cl:13])=[O:1]|US20200115372A1_0376
4.1.60|[C:9]-[N&H1&+0&D2:8]-[N&H2&+0&D1:7].[c:6]:[c&H0&+0&D3:5](:[n:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[C:9]-[n&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3]:1-[c&H0&+0&D3:5](:[c:6]):[n:4]|CN(C)[CH:1]=[CH:2][C:3](=O)[c:4]1[n:5][n:6]([cH:7][cH:8][c:9]1=[O:10])-[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[C:17]([F:18])([F:19])[F:20].[CH3:21][CH:22]([CH3:23])[NH:24][NH2:25].Cl>CCN(CC)CC.CCO.Cl>[CH3:21][CH:22]([CH3:23])[n:24]1[n:25][cH:1][cH:2][c:3]1-[c:4]1[n:5][n:6]([cH:7][cH:8][c:9]1=[O:10])-[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[C:17]([F:18])([F:19])[F:20]|US09018210B2_0397
4.1.60|[C:9]-[N&H1&+0&D2:8]-[N&H2&+0&D1:7].[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[C:9]-[n&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3]:1-[c&H0&+0&D3:5](:[c:6]):[c:4]|Cl.[CH3:1][n:2]1[c:3]([c:4]([cH:5][c:6]2[c:7]1[n:8]([c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]21)[C:15](=O)[CH:16]=[CH:17]N(C)C)[CH3:18])-[c:19]1[cH:20][cH:21][c:22]([cH:23][c:24]1[Cl:25])[Cl:26])=[O:27].[NH2:28][NH:29][CH:30]1[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1>>[CH3:1][n:2]1[c:3]([c:4]([cH:5][c:6]2[c:7]1[n:8]([c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]21)-[c:15]1[cH:16][cH:17][n:28][n:29]1[CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1)[CH3:18])-[c:19]1[cH:20][cH:21][c:22]([cH:23][c:24]1[Cl:25])[Cl:26])=[O:27]|US10214537B2_0883
4.1.53|[C:9]-[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[N&H2&+0&D1:6])=O.[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O-C>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:5]:[c&H0&+0&D3:4](:[n&H0&+0&D2:6]:[n&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|CO[C:1](=[NH:2])[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[F:9].[CH3:10][C:11]([CH3:12])([C:13]#[N:14])[C:15](=O)[NH:16][NH2:17]>CCN(CC)CC.CO.Cl>[CH3:10][C:11]([CH3:12])([C:13]#[N:14])[c:15]1[n:2][c:1]([n:17][nH:16]1)-[c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[F:9]|EP2457913B1_0374
4.1.53|[C:9]-[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[N&H2&+0&D1:6])=O.[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O-C>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:5]:[c&H0&+0&D3:4](:[n&H1&+0&D2:6]:[n&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([NH:14][C:15](=[O:16])[O:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[C:25](=O)[NH:26][NH2:27].CO[C:28](=[NH:29])[c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1.Cl>CCN(CC)CC.C1CCOC1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([NH:14][C:15](=[O:16])[O:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[c:25]1[n:29][c:28]([nH:27][n:26]1)-[c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1|US20120165339A1_0580
4.1.27|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O-C-C)=O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6](-[O&H1&+0&D1:5]):[c&H1&+0&D2:7]:1|CCO[C:1](=[O:2])[CH2:3][C:4](=O)[C:5]([F:6])([F:7])[F:8].[CH3:9][O:10][c:11]1[cH:12][cH:13][c:14]([c:15]([cH:16]1)[N+:17]([O-:18])=[O:19])[NH2:20]>O=P(O)(O)O>[CH3:9][O:10][c:11]1[cH:16][c:15]([c:14]2[n:20][c:4]([cH:3][c:1]([c:13]2[cH:12]1)[OH:2])[C:5]([F:6])([F:7])[F:8])[N+:17]([O-:18])=[O:19]|US20040106655A1_1494
4.2.50|[O&H0&D1:10]=[C&H0&+0&D3:9](-[C&H1&+0&D2:8]=[C&H1&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[c:4])-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[O&H0&D1:10]=[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[c&H0&+0&D3:7](:[o&H0&+0&D2:1]:[c:2]:[c:3]:1)-[c&H0&+0&D3:6](:[c:5]):[c:4]|[O:1]=[C:2]([OH:3])[c:4]1[cH:5][cH:6][c:7]([c:8]([cH:9]1)[C:10](=[O:11])[CH:12]=[CH:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH:20]=[CH:21][c:22]1[cH:23][cH:24][c:25]2[cH:26][cH:27][cH:28][cH:29][c:30]2[n:31]1)[OH:32]>C1COCCO1.O=[Se]=O>[O:11]=[c:10]1[cH:12][c:13]([o:32][c:7]2[cH:6][cH:5][c:4]([cH:9][c:8]12)[C:2](=[O:1])[OH:3])-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH:20]=[CH:21][c:22]1[cH:23][cH:24][c:25]2[cH:26][cH:27][cH:28][cH:29][c:30]2[n:31]1|US20190055218A1_0371
2.3.8|[N&H2&+0&D1:8]-[c:7]:[c:6]-[C&H0&+0&D3:5](-[N&H2&+0&D1:4])=[O&H0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[n&H1&+0&D2:8]1:[c:7]:[c:6]:[c&H0&+0&D3:5](:[n&H1&+0&D2:4]:[c&H0&+0&D3:1]:1=[O&H0&D1:2])=[O&H0&D1:3]|[NH2:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([c:7]([cH:8][c:9]1[NH2:10])[N+:11]([O-:12])=[O:13])[F:14].[O:15]=[C:16](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>C1CCOC1>[O-:12][N+:11](=[O:13])[c:7]1[cH:8][c:9]2[nH:10][c:16]([nH:1][c:2]([c:4]2[cH:5][c:6]1[F:14])=[O:3])=[O:15]|US09499495B2_0304
4.1.53|[C:9]-[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[N&H2&+0&D1:6])=O.[N&H1&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O-C>>[C:9]-[c&H0&+0&D3:8]1:[n&H1&+0&D2:5]:[c&H0&+0&D3:4](:[n&H0&+0&D2:6]:[n&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH:2]([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[C:12](=[O:13])[NH:14][C@H:15]([CH2:16][OH:17])[CH2:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[C:25](=[NH:26])OC.[CH3:27][C:28]([CH3:29])([CH3:30])[C:31](=O)[NH:32][NH2:33]>CC(=O)O>[CH3:1][CH:2]([CH3:3])[O:4][c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[C:12](=[O:13])[NH:14][C@H:15]([CH2:16][OH:17])[CH2:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)-[c:25]1[n:33][n:32][c:31]([nH:26]1)[C:28]([CH3:27])([CH3:29])[CH3:30]|US20200331888A1_0840
4.1.48|[C:9]-[C&H0&+0&D3:8](=[C&H1&+0&D2:7]-N(-C)-C)-[C&H0&+0&D3:6](-[C:5])=O.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N&H2&+0&D1:2])-[N:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](:[n&H0&+0&D2:2]:[c&H0&+0&D3:6]:1-[C:5])-[N:1]|CN(C)/[CH:1]=[C:2]1\[C:3]([CH2:4][S:5][CH2:6][C:7]1=O)=[O:8].[CH3:9][N:10]([CH3:11])[C:12](=[NH:13])[NH2:14]>CCO>[CH3:9][N:10]([CH3:11])[c:12]1[n:14][c:7]2[CH2:6][S:5][CH2:4][C:3]([c:2]2[cH:1][n:13]1)=[O:8]|US20180228907A1_1124
4.1.48|[C:9]-[C&H0&+0&D3:8](=[C&H1&+0&D2:7]-N(-C)-C)-[C&H0&+0&D3:6](-[C:5])=O.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N&H2&+0&D1:2])-[S:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](:[n&H0&+0&D2:2]:[c&H0&+0&D3:6]:1-[C:5])-[S:1]|CN(C)[CH:1]=[C:2]1[CH2:3][N:4]([CH2:5][C:6]1=O)[C:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[CH3:26][S:27][C:28](=[NH:29])[NH2:30].O=S(=O)(O)O>CCO.CC[O-].[Na+]>[CH3:26][S:27][c:28]1[n:29][cH:1][c:2]2[CH2:3][N:4]([CH2:5][c:6]2[n:30]1)[C:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1|US20090264401A1_1175
4.3.10|[N&H0&+0&D1:10]#[C&H0&+0&D2:9]-[c&H0&+0&D3:8](:[c:7]):[n:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3]:[c:2]-[S&H1&+0&D1:1])-O>>[n&H0&+0&D2:10]1:[c&H0&+0&D3:9](:[s&H0&+0&D2:1]:[c:2]:[c:3]:[c&H0&+0&D3:4]:1=[O&H0&D1:5])-[c&H0&+0&D3:8](:[c:7]):[n:6]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH2:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][c:14]([n:15]1)[C:16]#[N:17].[O:18]=[C:19](O)[c:20]1[cH:21][cH:22][c:23]([cH:24][c:25]1[SH:26])[Cl:27]>c1ccncc1>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[CH2:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][c:14]([n:15]1)-[c:16]1[n:17][c:19]([c:20]2[cH:21][cH:22][c:23]([cH:24][c:25]2[s:26]1)[Cl:27])=[O:18]|EP1897880A1_0201
4.1.126|[C:9]-[C&H0&+0&D3:8](=[C&H1&+0&D2:7]-O-C-C)-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O-C-C.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6]:1-[O&H1&+0&D1:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7]OCC)[C:8](=[O:9])OCC.[CH3:10][C:11]([CH3:12])([CH3:13])[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[NH2:20]>CCO>[CH3:10][C:11]([CH3:12])([CH3:13])[c:14]1[cH:15][cH:16][c:17]2[c:8]([c:6]([cH:7][n:20][c:18]2[cH:19]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1])[OH:9]|US20200377486A1_1117
4.1.55|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H0&+0&D3:8](-[C:7])=[C&H1&+0&D2:6]-[c:5])=O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:10]-[C&H0&+0&D3:9]1-[N&H1&+0&D2:4]-[c:3]:[c&H0&+0&D3:2](:[c:1])-[C&H1&+0&D3:6](-[c:5])-[C&H0&+0&D3:8]=1-[C:7]|[CH3:1][O:2][C:3](=[O:4])[C:5](=[CH:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[Cl:13])[C:14]([CH3:15])=O.[CH3:16][n:17]1[c:18]([cH:19][c:20]([n:21]([c:22]1=[O:23])[CH3:24])[NH2:25])=[O:26]>CC(=O)O>[CH3:15][C:14]1[NH:25][c:20]2[c:19]([c:18]([n:17]([c:22]([n:21]2[CH3:24])=[O:23])[CH3:16])=[O:26])[CH:6]([C:5]=1[C:3](=[O:4])[O:2][CH3:1])[c:7]1[cH:12][c:11]([cH:10][cH:9][cH:8]1)[Cl:13]|EP2132206B1_0269
2.3.10|[O&H0&D1:9]=[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[C&H0&+0&D3:6](=[S&H0&D1:5])-[N&H1&+0&D2:4]-[c:3]:[n&H1&+0&D2:2]:[n:1])-O-C-C>>[O&H0&D1:9]=[c&H0&+0&D3:8]1:[n&H1&+0&D2:7]:[c&H0&+0&D3:6](=[S&H0&D1:5]):[n&H1&+0&D2:4]:[c:3]:[n&H0&+0&D3:2]:1:[n:1]|CCO[C:1](=[O:2])[NH:3][C:4](=[S:5])[NH:6][c:7]1[cH:8][c:9]([n:10][nH:11]1)-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>O=S(=O)(O)O.O[Na]>[O:2]=[c:1]1[nH:3][c:4]([nH:6][c:7]2[cH:8][c:9]([n:10][n:11]12)-[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1)=[S:5]|US20200331917A1_1685
4.1.55|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H0&+0&D3:8](-[C:7])=[C&H1&+0&D2:6]-[c:5])=O.[C:4]/[C&H1&+0&D2:3]=[C:2]\[N&H2&+0&D1:1]>>[C&H3&D1:10]-[C&H0&+0&D3:9]1-[N&H1&+0&D2:1]-[C:2]=[C&H0&+0&D3:3](-[C:4])-[C&H1&+0&D3:6](-[c:5])-[C&H0&+0&D3:8]=1-[C:7]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[N+:14]([O-:15])=[O:16])[C:17]([CH3:18])=O.[CH3:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][O:29][C:30](=[O:31])/[CH:32]=[C:33](/[CH3:34])[NH2:35]>CCO>[CH3:18][C:17]1[NH:35][C:33](=[C:32]([CH:7]([C:6]=1[C:4](=[O:5])[O:3][CH2:2][CH3:1])[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[N+:14]([O-:15])=[O:16])[C:30](=[O:31])[O:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH3:19])[CH3:34]|EP0371492A2_0033
4.1.48|[C:9]-[C&H0&+0&D3:8](-[C&H0&+0&D3:7](-[C:6])=[C&H1&+0&D2:5]-N(-C)-C)=O.[C:4]-[C&H0&+0&D3:3](=[N&H1&+0&D1:2])-[N&H2&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:1]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:2]:[c&H1&+0&D2:5]:[c&H0&+0&D3:7]:1-[C:6]|[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][C:9](=[NH:10])[NH2:11])([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.CN(C)/[CH:24]=[C:25]1\[C:26]([CH2:27][CH2:28][CH2:29][C:30]1=[O:31])=O>>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][c:9]1[n:10][cH:24][c:25]2[C:30]([CH2:29][CH2:28][CH2:27][c:26]2[n:11]1)=[O:31])([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20190308945A1_0277
4.2.4|[C:9]-[C&H0&+0&D3:8](=[C&H1&+0&D2:7]-N(-C)-C)-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[N&H2&+0&D1:2]-[O&H1&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[n&H0&+0&D2:2]:[o&H0&+0&D2:1]:[c&H0&+0&D3:6]:1-[c&H0&+0&D3:5](:[c:4]):[c:3]|Cl.[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7]N(C)C)[C:8](=O)[c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[Cl:15])[Cl:16].[NH2:17][OH:18]>[Na+].CO.CCOCC.CC([O-])=O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:17][o:18][c:8]1-[c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[Cl:15])[Cl:16]|US20100022590A1_0136
4.1.55|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H0&+0&D3:8](-[c:7])=[C&H1&+0&D2:6]-[c:5])=O.[C:4]-[C&H1&+0&D2:3]=[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:10]-[C&H0&+0&D3:9]1-[N&H1&+0&D2:1]-[C:2]=[C&H0&+0&D3:3](-[C:4])-[C&H1&+0&D3:6](-[c:5])-[C&H0&+0&D3:8]=1-[c:7]|[CH3:1][C:2](=O)[C:3](=[CH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[N+:11]([O-:12])=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1.[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[C:25](=[O:26])[CH:27]=[C:28]([CH3:29])[NH2:30]>C1COCCO1.O=C(O)O[Na].Cl[Zn]Cl>[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[C:25](=[O:26])[C:27]1=[C:28]([NH:30][C:2](=[C:3]([CH:4]1[c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[N+:11]([O-:12])=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1)[CH3:1])[CH3:29]|EP0400660A1_0172
4.1.60|[C:9]-[C&H0&+0&D3:8](=[C&H1&+0&D2:7]-N(-C)-C)-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c&H0&+0&D3:6]:1-[c&H0&+0&D3:5](:[c:4]):[c:3]|O.CN(C)[CH:1]=[C:2]1[CH2:3][S:4][c:5]2[cH:6][cH:7][c:8]([cH:9][c:10]2[C:11]1=O)[Cl:12].[NH2:13][NH2:14]>CO.CC(=O)O>[Cl:12][c:8]1[cH:7][cH:6][c:5]2[S:4][CH2:3][c:2]3[cH:1][n:13][nH:14][c:11]3-[c:10]2[cH:9]1|US20050277630A1_0782
4.1.60|[C:9]-[C&H0&+0&D3:8](=[C&H1&+0&D2:7]-N(-C)-C)-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c&H0&+0&D3:6]:1-[c&H0&+0&D3:5](:[c:4]):[c:3]|O.CN(C)[CH:1]=[C:2]([C:3](=O)[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[Cl:10])[C:11](=[O:12])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[NH2:19][NH2:20]>CCO>[O:12]=[C:11]([c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)[c:2]1[cH:1][nH:19][n:20][c:3]1-[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[Cl:10]|EP2516435B1_0184
4.1.55|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H0&+0&D3:8](-[C:7])=[C&H1&+0&D2:6]-[c:5])=O.[C:4]-[C&H1&+0&D2:3]=[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:10]-[C&H0&+0&D3:9]1-[N&H1&+0&D2:1]-[C:2]=[C&H0&+0&D3:3](-[C:4])-[C&H1&+0&D3:6](-[c:5])-[C&H0&+0&D3:8]=1-[C:7]|[CH3:1][C:2](=O)[C:3](=[CH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([c:10]1[Cl:11])[Cl:12])[C:13](=[O:14])[O:15][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20]1.[CH3:21][O:22][C:23](=[O:24])[CH:25]=[C:26]([NH2:27])[CH2:28][F:29]>CC(C)(C)O>[CH3:21][O:22][C:23](=[O:24])[C:25]1=[C:26]([NH:27][C:2](=[C:3]([CH:4]1[c:5]1[cH:6][cH:7][cH:8][c:9]([c:10]1[Cl:11])[Cl:12])[C:13](=[O:14])[O:15][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20]1)[CH3:1])[CH2:28][F:29]|US09422263B2_0299
4.1.26|[C&H3&D1:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[C&H3&D1:5])=O)=O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6](-[C&H3&D1:5]):[c&H1&+0&D2:7]:1|[CH3:1][C:2](=O)[CH2:3][C:4]([CH3:5])=O.[NH2:6][c:7]1[cH:8][cH:9][cH:10][c:11]([n:12]1)[NH2:13]>O.[Na+].O=P(O)(O)O.[OH-]>[CH3:5][c:4]1[cH:3][c:2]([n:6][c:7]2[n:12][c:11]([cH:10][cH:9][c:8]12)[NH2:13])[CH3:1]|US20140249143A1_0815
4.1.46|[N&H2&+0&D1:9]-[c:8]:[c:7]-[N&H1&+0&D2:6]-[c&H0&+0&D3:5](:[c:4]):[c:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[n&H1&+0&D2:9]1:[c:8]:[c:7]:[n&H0&+0&D3:6](:[c&H0&+0&D3:1]:1=[O&H0&D1:2])-[c&H0&+0&D3:5](:[c:4]):[c:3]|[CH3:1][CH2:2][CH:3]([CH2:4][CH3:5])[O:6][c:7]1[n:8][c:9]([n:10][c:11]([c:12]1[NH2:13])[NH:14][c:15]1[c:16]([cH:17][c:18]([cH:19][c:20]1[CH3:21])[CH3:22])[CH3:23])[CH3:24].[O:25]=[C:26](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>CCN(CC)CC.C1CCOC1>[CH3:22][c:18]1[cH:19][c:20]([c:15]([c:16]([cH:17]1)[CH3:23])-[n:14]1[c:11]2[n:10][c:9]([n:8][c:7]([c:12]2[nH:13][c:26]1=[O:25])[O:6][CH:3]([CH2:4][CH3:5])[CH2:2][CH3:1])[CH3:24])[CH3:21]|US20150246902A1_0267
4.2.2|[C:9]/[C&H0&+0&D3:8](=[N&H0&+0&D2:7]/[#1])-[N&H1&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([c:8]1[Cl:9])[cH:10][c:11]([n:12]2[CH2:13]/[C:14](=[N:15]/[H])[NH:16]O)[CH:17]([F:18])[F:19].[O:20]=[C:21](O)[c:22]1[cH:23][n:24][cH:25][c:26]([cH:27]1)[Br:28]>CN(C)C(On1nnc2c1nccc2)=[N+](C)C.CCN(C(C)C)C(C)C.F[P-](F)(F)(F)(F)F.CN(C)C=O.C1CCOC1.O>[N:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([c:8]1[Cl:9])[cH:10][c:11]([n:12]2[CH2:13][c:14]1[n:15][c:21]([o:20][n:16]1)-[c:22]1[cH:23][n:24][cH:25][c:26]([cH:27]1)[Br:28])[CH:17]([F:18])[F:19]|EP2272848A1_0264
4.2.2|[C:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-O.[c:6]:[c&H0&+0&D3:5](:[c:4])/[C&H0&+0&D3:3](=[N&H0&+0&D2:2]/[#1])-[N&H1&+0&D2:1]-O>>[C:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[n&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:2]:1)-[c&H0&+0&D3:5](:[c:6]):[c:4]|[O:1]=[C:2](O)[CH2:3][N:4]1[CH2:5][CH2:6][C:7]([C:8]1=[O:9])([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.O[NH:22]/[C:23](=[N:24]\[H])[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[C:31]([F:32])([F:33])[F:34]>CCN=C=NCCCN(C)C.CC(Cl)Cl.Cl>[O:9]=[C:8]1[N:4]([CH2:5][CH2:6][C:7]1([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[CH2:3][c:2]1[n:24][c:23]([n:22][o:1]1)-[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[C:31]([F:32])([F:33])[F:34]|US08044069B2_0765
4.1.40|[N&H2&+0&D1:10]-[c:9]:[c:8]-[C&H0&+0&D3:7](-[N&H2&+0&D1:6])=[O&H0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:10]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:6]:[c&H0&+0&D3:7](=[O&H0&D1:5]):[c:8]:[c:9]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|[NH2:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[NH2:10].O=[CH:11][c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>O.[Na+].CC(=O)N(C)C.[O-]S(=O)O>[O:3]=[c:2]1[nH:1][c:11]([n:10][c:9]2[cH:8][cH:7][cH:6][cH:5][c:4]21)-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1|US09073878B2_0644
4.2.37|[C&H3&D1:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-O-C-C)=O.[O&H1&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[c&H0&+0&D3:6](=[O&H0&D1:5]):[o&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][C:2](=O)[CH2:3][C:4](=[O:5])OCC.[OH:6][c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[OH:13]>CCO.O=S(=O)(O)O>[CH3:1][c:2]1[cH:3][c:4]([o:6][c:7]2[cH:12][c:11]([cH:10][cH:9][c:8]12)[OH:13])=[O:5]|US20070123690A1_0106
4.1.40|[N&H2&+0&D1:10]-[c:9]:[c:8]-[C&H0&+0&D3:7](-[N&H2&+0&D1:6])=[O&H0&D1:5].[c:4]:[c&H0&+0&D3:3](:[n:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:10]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:6]:[c&H0&+0&D3:7](=[O&H0&D1:5]):[c:8]:[c:9]:1)-[c&H0&+0&D3:3](:[c:4]):[n:2]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[C:9]([NH2:10])=[O:11])[NH2:12])[O:13][CH3:14].O=[CH:15][c:16]1[cH:17][cH:18][cH:19][cH:20][n:21]1>O.[Na+].Cc1ccc(cc1)S(=O)(=O)O.CC(=O)N(C)C.[O-]S(=O)O>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]2[n:12][c:15]([nH:10][c:9]([c:8]12)=[O:11])-[c:16]1[cH:17][cH:18][cH:19][cH:20][n:21]1)[O:13][CH3:14]|US09765039B2_0838
4.1.34|[C&H3&D1:10]-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|Cl.[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([c:7]1[OH:8])[CH3:9])[C:10](=O)[CH2:11][CH3:12].[CH3:13][O:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[NH:21]N>O.CC(C)O>[CH3:13][O:14][c:15]1[cH:20][cH:19][c:18]2[nH:21][c:10]([c:11]([c:17]2[cH:16]1)[CH3:12])-[c:4]1[cH:3][c:2]([c:7]([c:6]([cH:5]1)[CH3:9])[OH:8])[CH3:1]|US20110071150A1_1390
4.1.4|[C:9]-[N&H0&+0&D2:8]=[N&H0&+&D2:7]=[N&H0&-&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D2:2]#[C&H0&+0&D2:1]-[#14](-C)(-C)-C>>[C:9]-[n&H0&+0&D3:8]1:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](:[n&H0&+0&D2:6]:[n&H0&+0&D2:7]:1)-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][CH2:2][c:3]1[cH:4][c:5]([n:6][c:7]([n:8]1)[NH2:9])-[c:10]1[cH:11][nH:12][c:13]2[n:14][cH:15][c:16]([cH:17][c:18]21)[C:19]#[C:20][Si](C)(C)C.[N-:21]=[N+:22]=[N:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>I[Cu]>[CH3:1][CH2:2][c:3]1[cH:4][c:5]([n:6][c:7]([n:8]1)[NH2:9])-[c:10]1[cH:11][nH:12][c:13]2[n:14][cH:15][c:16]([cH:17][c:18]12)-[c:19]1[cH:20][n:23]([n:22][n:21]1)[CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1|US08614226B2_0416
4.1.62|[N&H2&+0&D1:10]-[C&H0&+0&D3:9](=[O&H0&D1:8])-[c:7]:[c:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[n&H1&+0&D2:10]1:[c&H0&+0&D3:4](:[n&H0&+0&D2:5]:[c:6]:[c:7]:[c&H0&+0&D3:9]:1=[O&H0&D1:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=O)[NH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[C:16]([NH2:17])=[O:18]>O.Cl.CCO.O[Na].c1ccncc1>[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)-[c:8]1[n:9][c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[c:16]([nH:17]1)=[O:18]|US20200181149A1_0234
4.1.58|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)=O.[N&H2&+0&D1:4]-[c:3]:[c:2]-[N&H2&+0&D1:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:1]:[c:2]:[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][O:2][c:3]1[cH:4][cH:5][nH:6][c:7]1/[CH:8]=[C:9]1\[C:10]([NH:11][c:12]2[cH:13][cH:14][c:15]([c:16]([c:17]12)[NH2:18])[NH2:19])=[O:20].[CH3:21][C:22](=O)[C:23](=O)[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1>CCO>[CH3:1][O:2][c:3]1[cH:4][cH:5][nH:6][c:7]1/[CH:8]=[C:9]1\[C:10]([NH:11][c:12]2[cH:13][cH:14][c:15]3[n:19][c:23]([c:22]([n:18][c:16]3[c:17]12)[CH3:21])-[c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1)=[O:20]|US20100120778A1_0520
3.11.3|[C&H2&+0&D1:9]=[C&H1&+0&D2:8]-[C&H0&+0&D3:7](=[C&H2&+0&D1:6])-[C&H3&D1:5].[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C&H2&+0&D2:9]1-[C&H1&+0&D3:2](-[C:1])-[C&H1&+0&D3:3](-[C&H2&+0&D2:6]-[C&H0&+0&D3:7](-[C&H3&D1:5])=[C&H1&+0&D2:8]-1)-[C:4]|[CH2:1]=[CH:2][C:3](=[CH2:4])[CH3:5].[CH:6]1=[CH:7][CH:8]2[CH2:9][CH2:10][CH:11]1[CH2:12]2>Oc1cccc(c1O)O>[CH3:5][C:3]1=[CH:2][CH2:1][CH:6]2[CH:11]3[CH2:12][CH:8]([CH2:9][CH2:10]3)[CH:7]2[CH2:4]1|US09115330B2_0032
2.1.10|[O&H0&D1:10]=[C&H0&+0&D3:9](/[C&H1&+0&D2:8]=[C&H1&+0&D2:7]/[c:6]:[c:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1])-O-C-C>>[O&H0&D1:10]=[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[c&H1&+0&D2:7]:[c:6]:[c:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|CCO[C:1](=[O:2])/[CH:3]=[CH:4]/[c:5]1[c:6]([n:7][c:8]([n:9][c:10]1[NH:11][c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[S:25][CH3:26])[CH3:27]>C1CN=C2CCCCCN2C1.CC(C)N(CC)C(C)C.C1CCOC1.O>[CH3:26][S:25][c:8]1[n:7][c:6]([c:5]2[cH:4][cH:3][c:1]([n:11]([c:10]2[n:9]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:2])[CH3:27]|US09212182B2_1004
4.1.4|[C:9]-[N&H0&+0&D2:8]=[N&H0&+&D2:7]=[N&H0&-&D1:6].[n:5]:[c&H0&+0&D3:4](:[s:3])-[C&H0&+0&D2:2]#[C&H0&+0&D2:1]-[#14](-C)(-C)-C>>[C:9]-[n&H0&+0&D3:8]1:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](:[n&H0&+0&D2:6]:[n&H0&+0&D2:7]:1)-[c&H0&+0&D3:4](:[n:5]):[s:3]|[CH3:1][C:2](=[O:3])[O:4][C@H:5]1[C@H:6]([O:7][C@@H:8]([C@@H:9]([C@H:10]1[N:11]=[N+:12]=[N-:13])[O:14][C:15]([CH3:16])=[O:17])[S:18][c:19]1[cH:20][c:21]([c:22]([c:23]([cH:24]1)[Cl:25])[Cl:26])[Cl:27])[CH2:28][O:29][C:30]([CH3:31])=[O:32].C[Si](C)(C)[C:33]#[C:34][c:35]1[n:36][cH:37][cH:38][s:39]1>O.CN(C)C=O.F[Cs].ClCCl.I[Cu]>[CH3:31][C:30](=[O:32])[O:29][CH2:28][C@H:6]1[O:7][C@@H:8]([C@@H:9]([C@H:10]([C@H:5]1[O:4][C:2]([CH3:1])=[O:3])[n:11]1[cH:33][c:34]([n:13][n:12]1)-[c:35]1[n:36][cH:37][cH:38][s:39]1)[O:14][C:15]([CH3:16])=[O:17])[S:18][c:19]1[cH:24][c:23]([c:22]([c:21]([cH:20]1)[Cl:27])[Cl:26])[Cl:25]|US20200347089A1_0320
4.1.4|[C:9]-[N&H0&+0&D2:8]=[N&H0&+&D2:7]=[N&H0&-&D1:6].[c:5]:[c&H0&+0&D3:4](:[n:3])-[C&H0&+0&D2:2]#[C&H0&+0&D2:1]-[#14](-C)(-C)-C>>[C:9]-[n&H0&+0&D3:8]1:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](:[n&H0&+0&D2:6]:[n&H0&+0&D2:7]:1)-[c&H0&+0&D3:4](:[c:5]):[n:3]|[CH3:1][C:2](=[O:3])[O:4][C@H:5]1[C@H:6]([O:7][C@@H:8]([C@@H:9]([C@H:10]1[N:11]=[N+:12]=[N-:13])[O:14][C:15]([CH3:16])=[O:17])[S:18][c:19]1[cH:20][cH:21][c:22]([c:23]([cH:24]1)[Cl:25])[Cl:26])[CH2:27][O:28][C:29]([CH3:30])=[O:31].C[Si](C)(C)[C:32]#[C:33][c:34]1[cH:35][cH:36][c:37]([cH:38][n:39]1)[F:40]>CCN(CC)CC.CN(C)C=O.I[Cu]>[CH3:30][C:29](=[O:31])[O:28][CH2:27][C@H:6]1[O:7][C@@H:8]([C@@H:9]([C@H:10]([C@H:5]1[O:4][C:2]([CH3:1])=[O:3])[n:11]1[cH:32][c:33]([n:13][n:12]1)-[c:34]1[cH:35][cH:36][c:37]([cH:38][n:39]1)[F:40])[O:14][C:15]([CH3:16])=[O:17])[S:18][c:19]1[cH:20][cH:21][c:22]([c:23]([cH:24]1)[Cl:25])[Cl:26]|US20200347089A1_0444
4.3.10|[N&H0&+0&D1:10]#[C&H0&+0&D2:9]-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[c:3]:[c:2]-[S&H1&+0&D1:1])-O-C>>[n&H0&+0&D2:10]1:[c&H0&+0&D3:9](:[s&H0&+0&D2:1]:[c:2]:[c:3]:[c&H0&+0&D3:4]:1=[O&H0&D1:5])-[c&H0&+0&D3:8](:[c:7]):[c:6]|CO[C:1](=[O:2])[c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[SH:9].[N:10]#[C:11][c:12]1[cH:13][cH:14][cH:15][n:16][cH:17]1>CCN(CC)CC.Cc1ccccc1>[O:2]=[c:1]1[n:10][c:11]([s:9][c:8]2[cH:7][cH:6][cH:5][cH:4][c:3]12)-[c:12]1[cH:17][n:16][cH:15][cH:14][cH:13]1|US07659267B2_0389
1.3.8|[C:10]-[C&H0&+0&D3:9](=[C&H1&+0&D2:8]-[N&H1&+0&D2:7]-[C:6])-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[n&H0&+0&D3:7](-[C:6]):[c&H0&+0&D3:2](:[c:1]):[c:3]:[c&H0&+0&D3:5]:1=[O&H0&D1:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][NH:8][CH:9]1[CH2:10][CH2:11]1)[C:12](=[O:13])[c:14]1[cH:15][c:16]([c:17]([c:18]([c:19]1F)[F:20])[F:21])[F:22]>CN(C)C=O.F[Na]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8]([c:19]2[c:18]([c:17]([c:16]([cH:15][c:14]2[c:12]1=[O:13])[F:22])[F:21])[F:20])[CH:9]1[CH2:10][CH2:11]1|US20120058989A1_0593
1.3.7|[C:10]-[C&H0&+0&D3:9](=[C&H1&+0&D2:8]-[N&H1&+0&D2:7]-[C:6])-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[c:1])-Cl>>[C:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[n&H0&+0&D3:7](-[C:6]):[c&H0&+0&D3:2](:[c:1]):[c:3]:[c&H0&+0&D3:5]:1=[O&H0&D1:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][NH:8][CH:9]1[CH2:10][CH2:11]1)[C:12](=[O:13])[c:14]1[cH:15][c:16]([c:17]([c:18]([c:19]1Cl)[F:20])[CH3:21])[F:22]>CN(C)C=O.O=C(O[K])O[K]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8]([c:19]2[c:18]([c:17]([c:16]([cH:15][c:14]2[c:12]1=[O:13])[F:22])[CH3:21])[F:20])[CH:9]1[CH2:10][CH2:11]1|US07897607B2_0997
1.3.7|[C:10]-[C&H0&+0&D3:9](=[C&H1&+0&D2:8]-[N&H1&+0&D2:7]-[C:6])-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[C:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[n&H0&+0&D3:7](-[C:6]):[c&H0&+0&D3:2](:[n:1]):[c:3]:[c&H0&+0&D3:5]:1=[O&H0&D1:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][NH:8][CH:9]1[CH2:10][CH2:11]1)[C:12](=[O:13])[c:14]1[cH:15][c:16]([c:17]([n:18][c:19]1Cl)[Cl:20])[F:21]>CN(C)C=O.O=C(O[K])O[K]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8]([c:19]2[n:18][c:17]([c:16]([cH:15][c:14]2[c:12]1=[O:13])[F:21])[Cl:20])[CH:9]1[CH2:10][CH2:11]1|US20110269741A1_0321
4.1.62|[N&H2&+0&D1:10]-[c:9]:[c:8]-[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[c:4])=O.[N&H2&+0&D1:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-N>>[n&H1&+0&D2:10]1:[c:9]:[c:8]:[c&H0&+0&D3:7](:[n&H0&+0&D2:3]:[c&H0&+0&D3:2]:1=[O&H0&D1:1])-[c&H0&+0&D3:6](:[c:5]):[c:4]|N[C:1]([NH2:2])=[O:3].[NH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[C:11](=O)[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[F:18]>O.CN1CCCC1=O>[O:3]=[c:1]1[n:2][c:11]([c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]2[nH:4]1)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[F:18]|US08680110B2_0153
4.2.18|[N&H2&+0&D1:10]-[c:9]:[c:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-[O&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[n:2])-[C&H0&+0&D3:1](-O)=O>>[n&H0&+0&D2:10]1:[c:9]:[c:8]:[c&H0&+0&D3:7](=[O&H0&D1:6]):[o&H0&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[n:2]|O=[C:1](O)[c:2]1[cH:3][c:4]([n:5][n:6]1-[c:7]1[n:8][cH:9][cH:10][cH:11][c:12]1[Cl:13])[C:14]([F:15])([F:16])[F:17].[CH3:18][c:19]1[cH:20][c:21]([cH:22][c:23]([c:24]1[NH2:25])[C:26](=[O:27])[OH:28])[I:29]>CCN(CC)CC.CS(=O)(=O)Cl.CC#N>[CH3:18][c:19]1[cH:20][c:21]([cH:22][c:23]2[c:24]1[n:25][c:1]([o:28][c:26]2=[O:27])-[c:2]1[cH:3][c:4]([n:5][n:6]1-[c:7]1[n:8][cH:9][cH:10][cH:11][c:12]1[Cl:13])[C:14]([F:15])([F:16])[F:17])[I:29]|US20200339578A1_0368
4.1.70|[N&H2&+0&D1:10]-[N&H2&+0&D1:9].[O&H0&D1:8]=[C&H0&+0&D3:7](-[c:6]:[c:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)-O>>[n&H1&+0&D2:10]1:[n&H0&+0&D2:9]:[c&H0&+0&D3:4](:[c:5]:[c:6]:[c&H0&+0&D3:7]:1=[O&H0&D1:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|O.[NH2:1][NH2:2].[O:3]=[C:4](O)[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[C:11](=O)[c:12]1[cH:13][cH:14][s:15][cH:16]1>CCO>[O:3]=[c:4]1[nH:2][n:1][c:11]([c:10]2[cH:9][cH:8][cH:7][cH:6][c:5]21)-[c:12]1[cH:13][cH:14][s:15][cH:16]1|US09273068B2_1105
1.2.20|[C:10]-[C&H0&+0&D3:9](=[C&H1&+0&D2:8]-[N&H1&+0&D2:7]-[C:6])-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[c:1])-O-C>>[C:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[n&H0&+0&D3:7](-[C:6]):[c&H0&+0&D3:2](:[c:1]):[c:3]:[c&H0&+0&D3:5]:1=[O&H0&D1:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][NH:8][C@H:9]([CH2:10][O:11][Si:12]([CH3:13])([CH3:14])[C:15]([CH3:16])([CH3:17])[CH3:18])[CH:19]([CH3:20])[CH3:21])[C:22](=[O:23])[c:24]1[cH:25][c:26]([c:27]([cH:28][c:29]1OC)[O:30][CH3:31])[CH2:32][c:33]1[cH:34][cH:35][cH:36][c:37]([c:38]1[F:39])[Cl:40]>>[CH3:31][O:30][c:27]1[cH:28][c:29]2[c:24]([cH:25][c:26]1[CH2:32][c:33]1[cH:34][cH:35][cH:36][c:37]([c:38]1[F:39])[Cl:40])[c:22]([c:6]([cH:7][n:8]2[C@H:9]([CH2:10][O:11][Si:12]([CH3:13])([CH3:14])[C:15]([CH3:16])([CH3:17])[CH3:18])[CH:19]([CH3:20])[CH3:21])[C:4](=[O:5])[O:3][CH2:2][CH3:1])=[O:23]|EP2906540B1_0028
4.2.18|[N&H2&+0&D1:10]-[c:9]:[c:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-[O&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-O)=O>>[n&H0&+0&D2:10]1:[c:9]:[c:8]:[c&H0&+0&D3:7](=[O&H0&D1:6]):[o&H0&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:5][CH2:6][N:7]([CH2:8]1)[c:9]1[n:10][cH:11][cH:12][cH:13][c:14]1[C:15](=O)O.[CH3:16][c:17]1[cH:18][cH:19][cH:20][c:21]([c:22]1[C:23](=[O:24])[OH:25])[NH2:26]>O.CC#N.CN(C)C=O.O=C(n1ccnc1)n1ccnc1>[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:5][CH2:6][N:7]([CH2:8]1)[c:9]1[n:10][cH:11][cH:12][cH:13][c:14]1-[c:15]1[n:26][c:21]2[cH:20][cH:19][cH:18][c:17]([c:22]2[c:23]([o:25]1)=[O:24])[CH3:16]|US20140243195A1_0451
9.7.261|[C&H3&D1:9]-[#14&H0&+0&D4:8](-[C&H3&D1:7])(-[C&H3&D1:6])-[C&H0&+0&D2:5]#[N&H0&D1:4].[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&D1:9]-[#14&H0&+0&D4:8](-[C&H3&D1:7])(-[C&H3&D1:6])-[O&H0&+0&D2:1]-[C&H1&+0&D3:2](-[C:3])-[C&H0&+0&D2:5]#[N&H0&D1:4]|[CH2:1]=[C:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[CH:8]=[O:9].[CH3:10][Si:11]([CH3:12])([CH3:13])[C:14]#[N:15]>I[Zn]I>[CH2:1]=[C:2]1[CH2:3][CH2:4][CH:5]([CH2:6][CH2:7]1)[CH:8]([C:14]#[N:15])[O:9][Si:11]([CH3:10])([CH3:12])[CH3:13]|EP3239154A1_0956
9.7.261|[C&H3&D1:9]-[#14&H0&+0&D4:8](-[C&H3&D1:7])(-[C&H3&D1:6])-[C&H0&+0&D2:5]#[N&H0&D1:4].[O&H0&+0&D1:3]=[C&H1&+0&D2:2]-[c:1]>>[C&H3&D1:9]-[#14&H0&+0&D4:8](-[C&H3&D1:7])(-[C&H3&D1:6])-[O&H0&+0&D2:3]-[C&H1&+0&D3:2](-[c:1])-[C&H0&+0&D2:5]#[N&H0&D1:4]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([o:7]1)[Cl:8].[CH3:9][Si:10]([CH3:11])([CH3:12])[C:13]#[N:14].CCOCC>CCCCCC.CCOC(C)=O.I[Zn]I>[CH3:9][Si:10]([CH3:11])([CH3:12])[O:1][CH:2]([C:13]#[N:14])[c:3]1[cH:4][cH:5][c:6]([o:7]1)[Cl:8]|EP3604309A1_0131
4.1.12|[C&H3&D1:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)-Br.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D3:2](:[c:1]):[c:3]:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][CH:2](Br)[C:3](=O)[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[NH2:10][c:11]1[n:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[s:19]1>CC#N>[CH3:1][c:2]1[c:3]([n:10][c:11]2[s:19][c:18]3[cH:17][cH:16][cH:15][cH:14][c:13]3[n:12]21)-[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1|EP2262769B1_0053
4.1.62|[N&H2&+0&D1:10]-[C&H0&+0&D3:9](=[O&H0&D1:8])-[c:7]:[c:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-Cl)=O>>[n&H1&+0&D2:10]1:[c&H0&+0&D3:1](:[n&H0&+0&D2:5]:[c:6]:[c:7]:[c&H0&+0&D3:9]:1=[O&H0&D1:8])-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][CH2:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[C:11](=O)Cl.[NH2:12][C:13](=[O:14])[c:15]1[cH:16][cH:17][cH:18][c:19]([c:20]1[NH2:21])[C:22]([NH2:23])=[O:24]>O.CCO.O[Na].c1ccncc1>[CH3:1][CH2:2][CH2:3][O:4][c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1-[c:11]1[n:21][c:20]2[c:19]([cH:18][cH:17][cH:16][c:15]2[c:13]([nH:12]1)=[O:14])[C:22]([NH2:23])=[O:24]|US08889698B2_0972
4.2.18|[N&H2&+0&D1:10]-[c:9]:[c:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-[O&H1&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-Cl)=O>>[n&H0&+0&D2:10]1:[c:9]:[c:8]:[c&H0&+0&D3:7](=[O&H0&D1:6]):[o&H0&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[OH:10].O=[C:11](Cl)[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[Cl:18]>O.c1ccncc1>[O:9]=[c:8]1[o:10][c:11]([n:1][c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]21)-[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[Cl:18]|US20200030312A1_0163
4.2.3|[C&H3&D1:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[c&H0&+0&D3:4](:[n&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][C:2](=[O:3])[NH:4][NH:5][C:6](=O)[c:7]1[cH:8][cH:9][cH:10][c:11]([n:12]1)[O:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[C:20]([F:21])([F:22])[F:23]>CCOCC.O=P(Cl)(Cl)Cl.O>[CH3:1][c:2]1[n:4][n:5][c:6]([o:3]1)-[c:7]1[cH:8][cH:9][cH:10][c:11]([n:12]1)[O:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[C:20]([F:21])([F:22])[F:23]|US20200354353A1_0539
4.2.3|[C&H3&D1:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[c&H0&+0&D3:4](:[n&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=[O:3])[NH:4][NH:5][C:6](=O)[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1>CC(=O)OC(C)=O.O=[Cl](=O)(=O)O>[CH3:1][c:2]1[n:4][n:5][c:6]([o:3]1)-[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1|EP0152021A2_0205
4.1.59|[C&H3&D1:9]-[N&H1&+0&D2:8]-[N&H2&+0&D1:7].[C:6]-[C&H0&+0&D3:5](-[C&H0&+0&D2:4]#[N&H0&+0&D1:3])=[C&H0&+0&D3:2](-[C:1])-O-C>>[C&H3&D1:9]-[n&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:2](-[C:1]):[c&H0&+0&D3:5](-[C:6]):[c&H0&+0&D3:4]:1-[N&H2&+0&D1:3]|[CH3:1][NH:2][NH2:3].CO[C:4]([CH2:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[N+:12]([O-:13])=[O:14])=[C:15]([C:16]#[N:17])[C:18]#[N:19]>C1CCOC1>[CH3:1][n:2]1[n:3][c:4]([c:15]([c:18]1[NH2:19])[C:16]#[N:17])[CH2:5][c:6]1[cH:7][cH:8][cH:9][c:10]([cH:11]1)[N+:12]([O-:13])=[O:14]|US20200247800A1_0934
4.2.16|[C&H3&D1:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=O)[CH2:3][NH:4][C:5](=[O:6])[c:7]1[cH:8][cH:9][cH:10][n:11][cH:12]1>N.O=S(=O)(O)O>[CH3:1][c:2]1[cH:3][n:4][c:5]([o:6]1)-[c:7]1[cH:12][n:11][cH:10][cH:9][cH:8]1|US20110003815A1_0343
4.1.27|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-[C&H0&+0&D3:6](=[O&H0&D1:5])-O-C)=O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H1&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6](=[O&H0&D1:5]):[c&H0&+0&D3:8]:1-[C:7]|[CH3:1][CH2:2][C:3](=O)[CH:4]([CH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:12]([CH3:13])(=[O:14])=[O:15])[C:16](=[O:17])OC.[CH3:18][O:19][C:20](=[O:21])[CH2:22][O:23][c:24]1[cH:25][cH:26][c:27]([c:28]([cH:29]1)[NH2:30])[F:31]>C1COCCO1.O=P(O)(O)O.CC([O-])=O.O.[Na+]>[CH3:18][O:19][C:20](=[O:21])[CH2:22][O:23][c:24]1[cH:25][cH:26][c:27]([c:28]2[nH:30][c:3]([c:4]([c:16]([c:29]12)=[O:17])[CH2:5][c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:12]([CH3:13])(=[O:14])=[O:15])[CH2:2][CH3:1])[F:31]|EP1928457B1_0699
4.2.3|[N&H2&+0&D1:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](=[O&H0&+0&D1:6])-[c&H0&+0&D3:5](:[c:4]):[c:3].[S&H0&D1:2]=[C&H0&+0&D2:1]=S>>[n&H1&+0&D2:9]1:[c&H0&+0&D3:1](:[o&H0&+0&D2:6]:[c&H0&+0&D3:7](:[n&H0&+0&D2:8]:1)-[c&H0&+0&D3:5](:[c:4]):[c:3])=[S&H0&D1:2]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[C:16](=[O:17])[NH:18][NH2:19].[S:20]=[C:21]=S>CCO.O[K]>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])-[c:16]1[n:18][nH:19][c:21]([o:17]1)=[S:20]|US20100226881A1_0773
4.1.29|[C:11]-[C&H0&+0&D3:10](-[c:9]:[c:8]-[N&H2&+0&D1:7])=O.[c:6]:[c&H0&+0&D3:5]1:[n:4]-[C:3]-[C&H2&+0&D2:2]-[C&H0&+0&D3:1]-1=O>>[C:11]-[c&H0&+0&D3:10]1:[c&H0&+0&D3:2]2-[C:3]-[n:4]:[c&H0&+0&D3:5](:[c:6])-[c&H0&+0&D3:1]:2:[n&H0&+0&D2:7]:[c:8]:[c:9]:1|[CH3:1][CH2:2][C@:3]1([C:4]([O:5][CH2:6][c:7]2[c:8]([n:9]3[CH2:10][CH2:11][C:12]([c:13]3[cH:14][c:15]21)=O)=[O:16])=[O:17])[OH:18].[CH3:19][C:20](=[O:21])[NH:22][CH:23]1[CH2:24][CH2:25][c:26]2[cH:27][cH:28][cH:29][c:30]([c:31]2[C:32]1=O)[NH2:33]>Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O.c1ccncc1>[CH3:1][CH2:2][C@:3]1([C:4]([O:5][CH2:6][c:7]2[c:8]([n:9]3[CH2:10][c:11]4[c:32]5[c:31]6[c:26]([cH:27][cH:28][cH:29][c:30]6[n:33][c:12]4-[c:13]3[cH:14][c:15]21)[CH2:25][CH2:24][CH:23]5[NH:22][C:20]([CH3:19])=[O:21])=[O:16])=[O:17])[OH:18]|US20200384121A1_0266
4.2.2|[C&H3&D1:9]-[C&H0&+0&D3:8](-[O&H0&+0&D2:7]-[N&H0&+0&D2:6]=[C&H0&+0&D3:5](-[N&H2&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=O)[O:3][N:4]=[C:5]([NH2:6])[c:7]1[cH:8][n:9][c:10]([c:11]([cH:12]1)-[c:13]1[n:14][c:15]2[c:16]([n:17]([n:18][c:19]2[c:20]([nH:21]1)=[O:22])[CH3:23])[CH2:24][CH2:25][CH3:26])[O:27][CH2:28][CH:29]([CH3:30])[CH3:31]>c1conn1>[CH3:1][c:2]1[n:6][c:5]([n:4][o:3]1)-[c:7]1[cH:8][n:9][c:10]([c:11]([cH:12]1)-[c:13]1[n:14][c:15]2[c:19]([n:18][n:17]([c:16]2[CH2:24][CH2:25][CH3:26])[CH3:23])[c:20]([nH:21]1)=[O:22])[O:27][CH2:28][CH:29]([CH3:30])[CH3:31]|US09345244B2_0165
4.2.2|[C&H3&D1:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[N&H0&+0&D2:6]-[O&H0&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[O:9][CH3:10])[N+:11]([O-:12])=[O:13])[C:14](=O)[O:15][N:16]=[C:17]([CH3:18])[NH2:19]>CC(=O)O>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[O:9][CH3:10])[N+:11]([O-:12])=[O:13])-[c:14]1[n:19][c:17]([n:16][o:15]1)[CH3:18]|US10689378B2_0461
4.1.45|[N&H2&+0&D1:11]-[c:10]:[c:9]-[N&H1&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:1](:[n&H0&+0&D3:8](:[c:9]:[c:10]:1)-[c&H0&+0&D3:7](:[c:6]):[c:5])-[c&H0&+0&D3:3](:[c:4]):[c:2]|[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[NH:9][c:10]1[n:11][c:12]([n:13][c:14]([c:15]1[NH2:16])[Cl:17])[NH2:18].O=[CH:19][c:20]1[cH:21][cH:22][cH:23][c:24]([cH:25]1)[F:26]>CO.CC(=O)O>[N:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)-[n:9]1[c:10]2[n:11][c:12]([n:13][c:14]([c:15]2[n:16][c:19]1-[c:20]1[cH:21][cH:22][cH:23][c:24]([cH:25]1)[F:26])[Cl:17])[NH2:18]|EP3122748B1_0013
4.2.3|[C:9]-[C&H0&+0&D4:8](-O-C)(-O-C)-O-C.[N&H2&+0&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[o&H0&+0&D2:4]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]1([CH2:3][CH2:4][CH2:5][CH:6]1[CH2:7][NH:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[C:17](=[O:18])[NH:19][NH2:20])[CH3:21].CO[C:22]([CH2:23][CH2:24][CH2:25][CH3:26])(OC)OC>>[CH3:1][C:2]1([CH2:3][CH2:4][CH2:5][CH:6]1[CH2:7][NH:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)-[c:17]1[n:19][n:20][c:22]([o:18]1)[CH2:23][CH2:24][CH2:25][CH3:26])[CH3:21]|US20050004186A1_0403
1.3.8|[N&H2&+0&D1:10]-[C&H0&+0&D3:9](=[O&H0&D1:8])-[c:7]:[c&H0&+0&D3:6](:[n:5])-[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2](:[c:1])-F>>[n&H1&+0&D2:10]1:[c&H0&+0&D3:9](=[O&H0&D1:8]):[c:7]:[c&H0&+0&D3:6](:[n:5]):[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][O:2][c:3]1[n:4][c:5]([cH:6][c:7]([c:8]1-[c:9]1[cH:10][cH:11][c:12]([c:13]([cH:14]1)F)-[c:15]1[c:16]([cH:17][n:18][n:19]1[CH:20]1[CH2:21][CH2:22][O:23][CH2:24][CH2:25]1)[C:26]([NH2:27])=[O:28])[CH3:29])[CH3:30]>O.CN1CCCC1=O>[CH3:30][c:5]1[cH:6][c:7]([c:8]([c:3]([n:4]1)[O:2][CH3:1])-[c:9]1[cH:10][cH:11][c:12]2[c:15]3[c:16]([cH:17][n:18][n:19]3[CH:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[c:26]([nH:27][c:13]2[cH:14]1)=[O:28])[CH3:29]|US08563565B2_0719
4.1.40|[N&H0&+0&D1:10]#[C&H0&+0&D2:9]-[c&H0&+0&D3:8](:[c:7]):[c:6].[N&H2&+0&D1:5]-[c:4]:[c:3]-[C&H0&+0&D3:2](=[O&H0&+0&D1:1])-O>>[n&H0&+0&D2:10]1:[c&H0&+0&D3:9](:[n&H0&+0&D2:5]:[c:4]:[c:3]:[c&H0&+0&D3:2]:1-[O&H1&+0&D1:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[N:1]#[C:2][c:3]1[cH:4][cH:5][n:6][cH:7][cH:8]1.[NH2:9][c:10]1[cH:11][n:12][cH:13][cH:14][c:15]1[C:16](=[O:17])O>[Na+].CO.C[O-]>[OH:17][c:16]1[n:1][c:2]([n:9][c:10]2[cH:11][n:12][cH:13][cH:14][c:15]12)-[c:3]1[cH:4][cH:5][n:6][cH:7][cH:8]1|US20140315886A1_0448
4.1.45|[N&H2&+0&D1:11]-[c:10]:[c:9]-[N&H1&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[n:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:1](:[n&H0&+0&D3:8](:[c:9]:[c:10]:1)-[c&H0&+0&D3:7](:[c:6]):[n:5])-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][S:2][c:3]1[n:4][cH:5][cH:6][c:7]([n:8]1)[NH:9][c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[NH2:16])[O:17][CH3:18].O=[CH:19][c:20]1[cH:21][cH:22][c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[cH:29]1>O.CN(C)C=O.O=S(O[Na])S(=O)(=O)O[Na]>[CH3:18][O:17][c:13]1[cH:14][c:15]2[n:16][c:19]([n:9]([c:10]2[cH:11][cH:12]1)-[c:7]1[cH:6][cH:5][n:4][c:3]([n:8]1)[S:2][CH3:1])-[c:20]1[cH:21][cH:22][c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2[cH:29]1|US20170324049A1_0123
4.1.59|[C&H3&D1:9]-[C&H0&+0&D3:8](=[C&H0&+0&D3:7](-[C:6])-[C&H0&+0&D2:5]#[N&H0&+0&D1:4])-O-C.[C:3]-[N&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:1]:[n&H0&+0&D3:2](-[C:3]):[c&H0&+0&D3:5](-[N&H2&+0&D1:4]):[c&H0&+0&D3:7]:1-[C:6]|CO[C:1]([CH3:2])=[C:3]([C:4]#[N:5])[C:6]#[N:7].[NH2:8][NH:9][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14]1>COc1ccccc1-n1ncc(c1N)C#N>[CH3:2][c:1]1[n:8][n:9]([c:6]([c:3]1[C:4]#[N:5])[NH2:7])[CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14]1|US20200247800A1_0765
4.3.8|[N&H2&+0&D1:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](-[N&H2&D1:6])=[S&H0&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D2:1]#N>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:1](:[s&H0&+0&D2:5]:[c&H0&+0&D3:7](-[N&H2&D1:6]):[n&H0&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|N#[C:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[Cl:8].[NH2:9][C:10](=[S:11])[NH:12][NH2:13]>[NH4+].O.O=C(O)C(F)(F)F.[OH-]>[NH2:9][c:10]1[n:12][n:13][c:1]([s:11]1)-[c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[Cl:8]|US20130217664A1_1655
4.3.8|[N&H2&D1:9]-[C&H0&+0&D3:8](=[S&H0&+0&D1:7])-[N&H1&+0&D2:6]-[N&H1&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[N&H2&D1:9]-[c&H0&+0&D3:8]1:[s&H0&+0&D2:7]:[c&H0&+0&D3:4](:[n&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([c:7]1[Cl:8])[NH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1[C:16](=O)[NH:17][NH:18][C:19]([NH2:20])=[S:21])[Cl:22]>Cc1ccccc1.CS(=O)(=O)O>[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([c:7]1[Cl:8])[NH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1-[c:16]1[n:17][n:18][c:19]([s:21]1)[NH2:20])[Cl:22]|EP2546232A1_0217
4.1.27|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-[C&H0&+0&D3:6](=[O&H0&D1:5])-O-C)=O.[N&H2&+0&D1:4]-[c:3]:[n&H0&+0&D2:2]:[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6](=[O&H0&D1:5]):[c&H0&+0&D3:8]:1-[C:7]|[CH3:1][c:2]1[cH:3][cH:4][n:5][c:6]([c:7]1[CH3:8])[NH2:9].CO[C:10](=[O:11])[CH:12]1[CH2:13][CH2:14][CH2:15][C:16]1=O>COCCO>[CH3:8][c:7]1[c:2]([cH:3][cH:4][n:5]2[c:10]([c:12]3[CH2:13][CH2:14][CH2:15][c:16]3[n:9][c:6]12)=[O:11])[CH3:1]|US08772301B2_1718
4.1.29|[C:11]-[C&H0&+0&D3:10](-[C&H2&+0&D2:9]-[C:8])=O.[N&H2&+0&D1:7]-[c:6]:[c:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[c&H0&+0&D3:4](:[c&H0&+0&D3:9]:1-[C:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=O)[CH:8]([CH3:9])[CH3:10].[NH2:11][c:12]1[cH:13][cH:14][cH:15][cH:16][c:17]1[C:18](=O)[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25]>N.O.CC(=O)O.O=S(=O)(O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:18]([c:17]2[cH:16][cH:15][cH:14][cH:13][c:12]2[n:11][c:7]1[CH:8]([CH3:9])[CH3:10])-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[F:25]|US09199938B2_1088
4.1.24|[C&H3&D1:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[c:4])=O.[N&H0&-&D1:3]=[N&H0&+&D2:2]=[N&H0&+0&D2:1]-[#11]>>[C&H3&D1:9]-[n&H0&+0&D3:8]1:[n&H0&+0&D2:3]:[n&H0&+0&D2:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|[CH3:1][NH:2][C:3](=O)[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[CH2:10][Cl:11].[N-:12]=[N+:13]=[N:14][Na]>Cc1ccccc1.C[Si](C)(C)Cl.O=S(Cl)Cl>[CH3:1][n:2]1[n:12][n:13][n:14][c:3]1-[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[CH2:10][Cl:11]|US20060069128A1_0098
4.2.3|[C&H3&D1:9]-[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[n&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=O)[NH:3][NH:4][C:5](=[O:6])[c:7]1[c:8]2[nH:9][c:10]([c:11]([nH:12][c:13]2[cH:14][c:15]([c:16]1[CH3:17])[N+:18]([O-:19])=[O:20])=[O:21])=[O:22]>>[CH3:17][c:16]1[c:15]([cH:14][c:13]2[nH:12][c:11]([c:10]([nH:9][c:8]2[c:7]1-[c:5]1[n:4][n:3][c:2]([o:6]1)[CH3:1])=[O:22])=[O:21])[N+:18]([O-:19])=[O:20]|US20200407327A1_0733
4.1.12|[N&H4&+&D0:9].[C&H3&D1:8]-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[N&H0&+0&D3:5](-[C&H1&+0&D2:4]=O)-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[n&H0&+0&D2:9]1:[c&H1&+0&D2:4]:[n&H0&+0&D3:5](:[c&H1&+0&D2:6]:[c&H0&+0&D3:7]:1-[C&H3&D1:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH4+:1].CC([O-])=O.[CH3:2][C:3](=O)[CH2:4][N:5]([CH:6]=O)[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[N+:13]([O-:14])=[O:15]>Cc1ccccc1C.CC(=O)O>[CH3:2][c:3]1[cH:4][n:5]([cH:6][n:1]1)-[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[N+:13]([O-:14])=[O:15]|EP2455380A1_0309
4.1.62|[C&H3&D1:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[O&H0&+0&D2:5]-C)=O)=O.[N&H2&+0&D1:4]-[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H1&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[n:1]):[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:1)=[O&H0&+0&D1:5]|[CH3:1][c:2]1[n:3][nH:4][c:5]([c:6]1-[c:7]1[c:8]([cH:9][c:10]([cH:11][c:12]1[CH3:13])[CH3:14])[CH3:15])[NH2:16].[CH3:17][C:18](=O)[CH2:19][C:20](=O)[O:21]C>CC(=O)O>[CH3:14][c:10]1[cH:11][c:12]([c:7]([c:8]([cH:9]1)[CH3:15])-[c:6]1[c:2]([n:3][n:4]2[c:20]([cH:19][c:18]([nH:16][c:5]12)[CH3:17])=[O:21])[CH3:1])[CH3:13]|US10472370B2_0073
4.2.2|[C&H3&D1:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[N&H0&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[C:9](=[O:10])O)[I:11].[CH3:12][C:13]([NH2:14])=[N:15]O>CN(C)C(On1nnc2cccnc21)=[N+](C)C.On1nnc2ccccc21.CC(C)N(CC)C(C)C.F[P-](F)(F)(F)(F)F.CN(C)C=O>[CH3:12][c:13]1[n:14][c:9]([o:10][n:15]1)-[c:8]1[cH:7][cH:6][c:5]([cH:4][c:3]1[O:2][CH3:1])[I:11]|EP1581532B1_0618
4.1.59|[N&H0&+0&D1:9]#[C&H0&+0&D2:8]-[C&H1&+0&D3:7](-[C&H1&+0&D2:6]=O)-[c&H0&+0&D3:5](:[c:4]):[c:3].[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[N&H2&+0&D1:9]-[c&H0&+0&D3:8]1:[n&H1&+0&D2:1]:[n&H0&+0&D2:2]:[c&H1&+0&D2:6]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:5](:[c:4]):[c:3]|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[CH3:8])[CH:9]([C:10]#[N:11])[CH:12]=O)[CH3:13].[NH2:14][NH2:15].O>c1ccccc1.CC(=O)O.O.Cl>[CH3:1][c:2]1[cH:7][c:6]([c:5]([c:4]([cH:3]1)[CH3:13])-[c:9]1[cH:12][n:14][nH:15][c:10]1[NH2:11])[CH3:8]|US20120277224A1_1343
4.2.2|[C&H3&D1:9]-[C&H0&+0&D3:8](=[N&H1&+0&D1:7])-[N&H1&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])-O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][c:2]1[n:3][cH:4][n:5]([c:6]1[C:7](=[O:8])O)[CH3:9].[CH3:10][C:11](=[NH:12])[NH:13]O>CN(C)C=O.O=C(n1ccnc1)n1ccnc1>[CH3:10][c:11]1[n:12][c:7]([o:8][n:13]1)-[c:6]1[c:2]([n:3][cH:4][n:5]1[CH3:9])[CH3:1]|US07858649B2_0158
4.2.3|[C&H3&D1:9]-[C&H0&+0&D3:8](=O)-O.[N&H2&+0&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[o&H0&+0&D2:4]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][n:5]1[c:6]([c:7]([c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[c:14]1=[O:15])[C:16](=[O:17])[NH:18][NH2:19])-[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[CH2:26][NH:27][C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34].[CH3:35][C:36](=O)O>C1CN=C2CCCCCN2C1.COC(C)(OC)OC.CCCCO>[CH3:1][CH:2]([CH3:3])[CH2:4][n:5]1[c:6]([c:7]([c:8]2[cH:9][c:10]([cH:11][cH:12][c:13]2[c:14]1=[O:15])-[c:16]1[n:18][n:19][c:36]([o:17]1)[CH3:35])-[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)[CH2:26][NH:27][C:28](=[O:29])[O:30][C:31]([CH3:34])([CH3:32])[CH3:33]|EP2668183B1_0117
4.2.2|[C&H3&D1:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[N&H0&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=[O:3])O.[CH3:4][CH2:5][CH2:6][CH2:7][O:8][C:9](=[O:10])[N:11]([CH3:12])[C@H:13]([CH2:14][NH:15][C:16](=[O:17])[CH2:18][CH:19]1[CH2:20][C:21](=[N:22][O:23]1)[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[C:30]([NH2:31])=[N:32]O)[C:33](=[O:34])[OH:35]>CC(=O)OC(C)=O>[CH3:4][CH2:5][CH2:6][CH2:7][O:8][C:9](=[O:10])[N:11]([CH3:12])[C@H:13]([CH2:14][NH:15][C:16](=[O:17])[CH2:18][CH:19]1[CH2:20][C:21](=[N:22][O:23]1)[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)-[c:30]1[n:31][c:2]([o:3][n:32]1)[CH3:1])[C:33](=[O:34])[OH:35]|US20110003815A1_0271
3.11.3|[C:9]-[C&H1&+0&D2:8]=[C&H1&+0&D2:7]-[C:6].[c&H1&+0&D2:5]1:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c&H1&+0&D2:2]:[o&H0&+0&D2:1]:1>>[C:9]-[C&H1&+0&D3:8]1-[C&H1&+0&D3:7](-[C:6])-[C&H1&+0&D3:5]2-[C&H1&+0&D2:4]=[C&H1&+0&D2:3]-[C&H1&+0&D3:2]-1-[O&H0&+0&D2:1]-2|[O:1]=[C:2]1[CH:3]=[CH:4][C:5]([O:6]1)=[O:7].[cH:8]1[cH:9][cH:10][o:11][cH:12]1>>[O:1]=[C:2]1[O:6][C:5]([CH:4]2[CH:12]3[CH:8]=[CH:9][CH:10]([O:11]3)[CH:3]12)=[O:7]|US20200113181A1_0174
4.2.3|[C&H3&D1:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[N&H2&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-O)=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[o&H0&+0&D2:7]:[c&H0&+0&D3:1](:[n&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][C:2](=[O:3])[NH:4][NH2:5].O=[C:6](O)[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[I:13]>CCOC(C)=O.O=P(Cl)(Cl)Cl>[CH3:1][c:2]1[n:4][n:5][c:6]([o:3]1)-[c:7]1[cH:12][cH:11][c:10]([cH:9][cH:8]1)[I:13]|EP2831053B1_0490
4.1.62|[C:9]-[C&H0&+0&D3:8](-[C&H1&+0&D3:7](-[C:6])-[C&H0&+0&D3:5](=[O&H0&D1:4])-O-C)=O.[N&H1&+0&D1:3]=[C&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:3]:[c&H1&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:5](=[O&H0&D1:4]):[c&H0&+0&D3:7]:1-[C:6]|CO[C:1](=[O:2])[CH:3]1[CH2:4][CH2:5][N:6]([CH2:7][C:8]1=O)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1.[NH:16]=[CH:17][NH2:18]>Cl.CC(=O)O>[O:2]=[c:1]1[nH:18][cH:17][n:16][c:8]2[CH2:7][N:6]([CH2:5][CH2:4][c:3]21)[CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US20190248767A1_0230
4.3.3|[C:10]-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5])-[N:2]|Cl.[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][NH:6][C:7]([NH2:8])=[S:9].[O:10]=[C:11]([NH:12][c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[C:19](=[O:20])[N:21]1[CH2:22][CH2:23][CH2:24][C:25]([c:26]2[cH:27][cH:28][cH:29][cH:30][c:31]21)=O)[c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1-[c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1>CCO>[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][NH:6][c:7]1[n:8][c:25]2-[c:26]3[cH:27][cH:28][cH:29][cH:30][c:31]3[N:21]([CH2:22][CH2:23][c:24]2[s:9]1)[C:19](=[O:20])[c:16]1[cH:17][cH:18][c:13]([cH:14][cH:15]1)[NH:12][C:11](=[O:10])[c:32]1[cH:33][cH:34][cH:35][cH:36][c:37]1-[c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1|US20140349994A1_0630
3.11.3|[C:9]-[C&H1&+0&D2:8]=[C&H1&+0&D2:7]-[C:6].[c&H1&+0&D2:5]1:[c&H1&+0&D2:4]:[c&H1&+0&D2:3]:[c&H1&+0&D2:2]:[o&H0&+0&D2:1]:1>>[C:9]-[C&H1&+0&D3:8]1-[C&H1&+0&D3:7](-[C:6])-[C&H1&+0&D3:2]2-[C&H1&+0&D2:3]=[C&H1&+0&D2:4]-[C&H1&+0&D3:5]-1-[O&H0&+0&D2:1]-2|[O:1]=[C:2]1[CH:3]=[CH:4][C:5]([N:6]1[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)=[O:13].[cH:14]1[cH:15][cH:16][o:17][cH:18]1>>[O:1]=[C:2]1[CH:3]2[CH:4]([C:5]([N:6]1[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)=[O:13])[CH:18]1[CH:14]=[CH:15][CH:16]2[O:17]1|US06677464B2
4.2.2|[C&H3&D1:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-O.[N&H1&+0&D1:6]=[C&H0&+0&D3:5](-[N&H1&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=[O:3])O.[NH:4]=[C:5]([NH:6]O)[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[CH2:13][N:14]([CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]1=[O:22])[S:23](=[O:24])(=[O:25])[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[Cl:32]>O.CN(C)C=O.O=C(n1ccnc1)n1ccnc1>[CH3:1][c:2]1[n:4][c:5]([n:6][o:3]1)-[c:7]1[cH:12][cH:11][c:10]([cH:9][cH:8]1)[CH2:13][N:14]([CH:15]1[CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]1=[O:22])[S:23](=[O:24])(=[O:25])[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[Cl:32]|US20060019998A1_0214
4.1.62|[C&H3&D1:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[O&H0&+0&D2:5]-C)=O)=O.[N&H2&+0&D1:4]-[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[n:1]):[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:1)-[O&H1&+0&D1:5]|[CH3:1][C:2](=O)[CH2:3][C:4](=O)[O:5]C.[NH2:6][c:7]1[cH:8][c:9]([n:10][nH:11]1)-[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>CC(=O)O>[CH3:1][c:2]1[cH:3][c:4]([n:11]2[n:10][c:9]([cH:8][c:7]2[n:6]1)-[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1)[OH:5]|US09963451B2_0441
4.3.8|[N&H2&+0&D1:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](-[N&H2&D1:6])=[S&H0&+0&D1:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-O)=O>>[n&H0&+0&D2:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:7](-[N&H2&D1:6]):[s&H0&+0&D2:5]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2]|[NH2:1][C:2](=[S:3])[NH:4][NH2:5].O=[C:6](O)[c:7]1[cH:8][cH:9][c:10]2[cH:11][n:12][cH:13][cH:14][c:15]2[cH:16]1>O=P(Cl)(Cl)Cl>[NH2:1][c:2]1[n:4][n:5][c:6]([s:3]1)-[c:7]1[cH:8][cH:9][c:10]2[cH:11][n:12][cH:13][cH:14][c:15]2[cH:16]1|EP3736271A1_0233
4.1.27|[C&H3&D1:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O-C)=O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6](-[O&H1&+0&D1:5]):[c&H1&+0&D2:7]:1|[CH3:1][C:2](=O)[CH2:3][C:4](=[O:5])OC.[CH3:6][c:7]1[cH:8][cH:9][cH:10][cH:11][c:12]1[NH2:13]>>[CH3:1][c:2]1[cH:3][c:4]([c:11]2[cH:10][cH:9][cH:8][c:7]([c:12]2[n:13]1)[CH3:6])[OH:5]|US20090023773A1_0353
4.2.2|[C&H3&D1:9]-[C&H0&+0&D3:8](=[N&H1&+0&D1:7])-[N&H1&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=[NH:3])[NH:4]O.[O:5]=[C:6](O)[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[C:13]1[CH2:14][C:15]([NH:16][c:17]2[cH:18][c:19]([cH:20][cH:21][c:22]2[N:23]=1)-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30])=[O:31]>CC#N.CN(C)C=O.On1nnc2ccccc21.ClCCCl>[CH3:1][c:2]1[n:3][c:6]([o:5][n:4]1)-[c:7]1[cH:8][cH:9][cH:10][c:11]([cH:12]1)[C:13]1[CH2:14][C:15]([NH:16][c:17]2[cH:18][c:19]([cH:20][cH:21][c:22]2[N:23]=1)-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[F:30])=[O:31]|US20200339522A1_1477
4.2.2|[C&H3&D1:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[N&H0&+0&D2:6]-O.[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])-O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:4](:[o&H0&+0&D2:5]:[n&H0&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][C:2]([NH2:3])=[N:4]O.[O:5]=[C:6](O)[c:7]1[n:8][cH:9][n:10]2[c:11]1[C@@H:12]1[CH2:13][CH2:14][CH2:15][N:16]1[C:17]([c:18]1[cH:19][c:20]([cH:21][cH:22][c:23]1-2)[F:24])=[O:25]>O.CN(C)C=O.O=C(n1ccnc1)n1ccnc1>[CH3:1][c:2]1[n:3][c:6]([o:5][n:4]1)-[c:7]1[n:8][cH:9][n:10]2-[c:23]3[cH:22][cH:21][c:20]([cH:19][c:18]3[C:17]([N:16]3[CH2:15][CH2:14][CH2:13][C@H:12]3[c:11]12)=[O:25])[F:24]|US08575167B2_0839
4.1.71|[Br&H0&D1:9]/[C&H0&+0&D3:8](-[C&H1&+0&D2:7]=O)=[C&H0&+0&D3:6](/[C:5])-Br.[C:4]-[C&H0&+0&D3:3](=[N&H1&+0&D1:2])-[N&H2&+0&D1:1]>>[Br&H0&D1:9]-[c&H0&+0&D3:8]1:[c&H1&+0&D2:7]:[n&H0&+0&D2:1]:[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:2]:[c&H0&+0&D3:6]:1-[C:5]|[O:1]=[C:2]([OH:3])[C:4](/Br)=[C:5](/[Br:6])[CH:7]=O.[CH3:8][C:9]([CH3:10])([CH3:11])[C:12](=[NH:13])[NH2:14].Cl>CCO.CC[O-].[Na+].Cl>[CH3:8][C:9]([CH3:10])([CH3:11])[c:12]1[n:13][c:4]([c:5]([cH:7][n:14]1)[Br:6])[C:2](=[O:1])[OH:3]|US10676482B2_0373
4.2.16|[C&H3&D1:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[O&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[o&H0&+0&D2:6]:1)-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][C:2]([NH2:3])=[O:4].[O:5]=[C:6]([OH:7])[c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[C:14](=O)[CH2:15]Br>>[CH3:1][c:2]1[n:3][c:14]([cH:15][o:4]1)-[c:12]1[cH:13][c:8]([cH:9][cH:10][cH:11]1)[C:6](=[O:5])[OH:7]|EP1379511B1_0204
4.3.3|[C&H3&D1:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-Cl)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[s&H0&+0&D2:4]:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[O:9][CH3:10])[O:11][CH3:12])[C:13]([NH2:14])=[S:15].[CH3:16][C:17](=O)[CH2:18]Cl>c1ccccc1>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[O:9][CH3:10])[O:11][CH3:12])-[c:13]1[n:14][c:17]([cH:18][s:15]1)[CH3:16]|US20050277676A1_0288
4.3.3|[N&H2&+0&D1:9]-[C&H0&+0&D3:8](-[N&H2&D1:7])=[S&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[N&H2&D1:7])-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][c:2]1[nH:3][c:4]([c:5]([cH:6][c:7]1[C:8](=O)[CH2:9]Br)[C:10]#[N:11])=[O:12].[NH2:13][C:14]([NH2:15])=[S:16]>CN(C)C=O>[CH3:1][c:2]1[nH:3][c:4]([c:5]([cH:6][c:7]1-[c:8]1[cH:9][s:16][c:14]([n:15]1)[NH2:13])[C:10]#[N:11])=[O:12]|EP3556756A1_0130
4.3.3|[N&H2&+0&D1:9]-[C&H0&+0&D3:8](-[N&H2&D1:7])=[S&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[n:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[N&H2&D1:7])-[c&H0&+0&D3:4](:[c:5]):[n:3]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([nH:9][n:10]1)[C:11](=O)[CH2:12]Br.[NH2:13][C:14]([NH2:15])=[S:16]>CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([nH:9][n:10]1)-[c:11]1[cH:12][s:16][c:14]([n:15]1)[NH2:13]|EP3556756A1_0155
4.2.2|[C&H3&D1:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-Cl.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[N&H0&+0&D2:4]-O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H0&+0&D2:4]:[o&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=[O:3])Cl.[NH2:4][C:5](=[N:6]O)[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[I:13]>c1ccncc1>[CH3:1][c:2]1[n:4][c:5]([n:6][o:3]1)-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[I:13]|US20090105305A1_0711
4.3.3|[N&H2&+0&D1:9]-[C&H0&+0&D3:8](-[N&H2&D1:7])=[S&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Cl)=O>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[N&H2&D1:7])-[c&H0&+0&D3:4](:[c:5]):[c:3]|[NH2:1][C:2]([NH2:3])=[S:4].O=[C:5]([CH2:6]Cl)[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[O:13][CH2:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[Cl:21]>CCOCC.CCO>[NH2:1][c:2]1[n:3][c:5]([cH:6][s:4]1)-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[O:13][CH2:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[Cl:21]|EP0527922B1_0054
4.3.3|[C&H3&D1:9]-[C&H0&+0&D3:8](-[N&H2&+0&D1:7])=[S&H0&+0&D1:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H0&+0&D3:2](:[c&H1&+0&D2:1]:[s&H0&+0&D2:6]:1)-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][C:2]([NH2:3])=[S:4].[O:5]=[C:6]([OH:7])[c:8]1[cH:9][c:10]([cH:11][cH:12][c:13]1[OH:14])[C:15](=O)[CH2:16]Br>CCO>[CH3:1][c:2]1[n:3][c:15]([cH:16][s:4]1)-[c:10]1[cH:11][cH:12][c:13]([c:8]([cH:9]1)[C:6](=[O:5])[OH:7])[OH:14]|US20170137415A1_0468
4.1.45|[N&H2&+0&D1:11]-[c:10]:[c:9]-[N&H1&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-Cl)=O>>[n&H0&+0&D2:11]1:[c:10]:[c:9]:[n&H0&+0&D3:8](:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2])-[c&H0&+0&D3:7](:[c:6]):[c:5]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1.O=[C:15](Cl)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1>CCN(CC)CC.CCOCC.ClCCl>[cH:12]1[cH:13][cH:14][c:9]([cH:10][cH:11]1)-[n:8]1[c:7]2[cH:6][cH:5][cH:4][cH:3][c:2]2[n:1][c:15]1-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20130172570A1_0029
9.7.17|[C&H3&D1:9]-[C&H0&+0&D4:8](-[C&H3&D1:7])(-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-O)-O.[O&H1&+0&D1:3]-[B:2]-[O&H1&+0&D1:1]>>[C&H3&D1:9]-[C&H0&+0&D4:8]1(-[C&H3&D1:7])-[O&H0&+0&D2:3]-[B:2]-[O&H0&+0&D2:1]-[C&H0&+0&D4:6]-1(-[C&H3&D1:5])-[C&H3&D1:4]|[O:1]=[CH:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[B:9]([OH:10])[OH:11].[CH3:12][C:13]([CH3:14])(O)[C:15]([CH3:16])([CH3:17])O>Cc1ccccc1.O>[CH3:12][C:13]1([O:10][B:9]([O:11][C:15]1([CH3:16])[CH3:17])[c:6]1[cH:5][cH:4][c:3]([cH:8][cH:7]1)[CH:2]=[O:1])[CH3:14]|US20200078343A1_0089
4.2.3|[N&H2&+0&D1:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](=[O&H0&+0&D1:6])-[c&H0&+0&D3:5](:[c:4]):[c:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-Cl)-Cl>>[n&H1&+0&D2:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:7](:[o&H0&+0&D2:6]:[c&H0&+0&D3:1]:1=[O&H0&D1:2])-[c&H0&+0&D3:5](:[c:4]):[c:3]|[NH2:1][NH:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[N+:11]([O-:12])=[O:13].[O:14]=[C:15](Cl)Cl>CCN(CC)CC.c1ccccc1>[O-:12][N+:11](=[O:13])[c:10]1[cH:9][cH:8][cH:7][cH:6][c:5]1-[c:3]1[n:2][nH:1][c:15]([o:4]1)=[O:14]|US20120101100A1_0603
4.2.16|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:10]-[c&H0&+0&D3:9]1:[o&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[C:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]([NH:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=O)[CH:18]([CH3:19])[CH3:20]>CN(C)C=O.O=P(Cl)(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[n:8][c:9]([o:10][c:17]1[CH:18]([CH3:19])[CH3:20])-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US20100022541A1_0104
4.1.53|[C:10]-[C&H0&+0&D3:9](=[N&H0&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5])-[N&H1&+0&D2:4]-[N&H1&+0&D2:3]-[C&H0&+0&D3:2](-[C:1])=O>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D3:8](:[c&H0&+0&D3:2](-[C:1]):[n&H0&+0&D2:3]:[n&H0&+0&D2:4]:1)-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][CH2:2][C:3](=O)[NH:4][NH:5][C:6]1[CH2:7][N:8]=[C:9]([c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[N:16]=1)[Cl:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>>[CH3:1][CH2:2][c:3]1[n:4][n:5][c:6]2[CH2:7][N:8]=[C:9]([c:10]3[cH:11][c:12]([cH:13][cH:14][c:15]3-[n:16]12)[Cl:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US04250094A
4.1.14|[C:10]-[C&H1&+0&D3:9](-[C&H2&+0&D2:8]-[C&H1&+0&D2:7]=O)-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[c&H1&+0&D2:7]:[n&H0&+0&D3:1](-[C:2]):[c&H0&+0&D3:6]:1-[c&H0&+0&D3:5](:[c:4]):[c:3]|[CH3:1][C:2](=[O:3])[NH:4][CH2:5][CH2:6][NH2:7].O=[CH:8][CH2:9][CH:10]1[CH2:11][CH2:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]2[C:19]1=O>CCOCC>[CH3:1][C:2](=[O:3])[NH:4][CH2:5][CH2:6][n:7]1[cH:8][cH:9][c:10]2[CH2:11][CH2:12][c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]3-[c:19]21|EP0990650A1_0086
4.1.60|[C:10]-[C&H0&+0&D3:9](=[C&H1&+0&D2:8]-O)-[C&H0&+0&D3:7](-[C:6])=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7]:1-[C:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[NH:10][NH2:11].O=[C:12]1[CH2:13][CH:14]2[CH2:15][CH2:16][CH2:17][CH:18]([C:19]1=[CH:20]O)[N:21]2[S:22](=[O:23])(=[O:24])[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[Cl:31]>>[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)-[n:10]1[n:11][cH:20][c:19]2[c:12]1[CH2:13][CH:14]1[CH2:15][CH2:16][CH2:17][CH:18]2[N:21]1[S:22](=[O:23])(=[O:24])[c:25]1[cH:26][cH:27][c:28]([cH:29][cH:30]1)[Cl:31]|US20190381019A1_1356
4.1.8|[C:10]-[N&H1&+0&D2:9]-[N&H2&+0&D1:8].[C:7]-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)=O>>[C:10]-[n&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:6](-[C:7]):[c&H1&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])[C:11](=O)[CH2:12][C:13](=O)[C:14]([F:15])([F:16])[F:17].[NH2:18][NH:19][CH2:20][C:21]([F:22])([F:23])[F:24]>Cc1ccc(cc1)S(=O)(=O)O.Cc1ccccc1>[CH3:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10])-[c:11]1[cH:12][c:13]([n:18][n:19]1[CH2:20][C:21]([F:22])([F:23])[F:24])[C:14]([F:15])([F:16])[F:17]|US20190382349A1_0736
4.1.14|[C:10]-[N&H2&+0&D1:9].[c:8]:[c&H0&+0&D3:7]1:[c:6]-[C:5]-[C&H1&+0&D3:4](-[C&H2&+0&D2:3]-[C&H1&+0&D2:2]=O)-[C&H0&+0&D3:1]-1=O>>[C:10]-[n&H0&+0&D3:9]1:[c&H1&+0&D2:2]:[c&H1&+0&D2:3]:[c&H0&+0&D3:4]2-[C:5]-[c:6]:[c&H0&+0&D3:7](:[c:8])-[c&H0&+0&D3:1]:1:2|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([cH:8]1)[C:9]([CH:10]([C:11]2([CH3:12])[CH3:13])[CH2:14][CH:15]=O)=O.[CH3:16][C@@H:17]([OH:18])[CH2:19][NH2:20]>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:16][C@@H:17]([OH:18])[CH2:19][n:20]1[cH:15][cH:14][c:10]2[c:9]1-[c:7]1[cH:8][c:3]([cH:4][cH:5][c:6]1[C:11]2([CH3:12])[CH3:13])[O:2][CH3:1]|US05646173A
4.2.16|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[n:1])=O>>[C:10]-[c&H0&+0&D3:9]1:[o&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[C:7])-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][CH:2]([CH3:3])[CH2:4][C:5](=O)[CH:6]([NH:7][C:8](=[O:9])[c:10]1[cH:11][cH:12][cH:13][cH:14][n:15]1)[C:16](=[O:17])[O:18][CH2:19][CH3:20]>O=P(Cl)(Cl)Cl>[CH3:20][CH2:19][O:18][C:16](=[O:17])[c:6]1[n:7][c:8]([o:9][c:5]1[CH2:4][CH:2]([CH3:1])[CH3:3])-[c:10]1[cH:11][cH:12][cH:13][cH:14][n:15]1|US20120029190A1_1154
2.3.8|[C:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-[c:5]:[c:4]-[N&H2&+0&D1:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[C:9]-[n&H0&+0&D3:8]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:3]:[c:4]:[c:5]:[c&H0&+0&D3:7]:1=[O&H0&D1:6])=[O&H0&D1:2]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][NH:7][C:8](=[O:9])[c:10]1[cH:11][c:12]([cH:13][cH:14][c:15]1[NH2:16])[I:17].[O:18]=[C:19](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>CCN(CC)CC.ClCCl.O.O>[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH2:6][n:7]1[c:8]([c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[nH:16][c:19]1=[O:18])[I:17])=[O:9]|US10239843B2_2252
4.1.59|[N&H0&+0&D1:9]#[C&H0&+0&D2:8]-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[N&H2&+0&D1:9]-[c&H0&+0&D3:8]1:[n&H1&+0&D2:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:5](:[c:4]):[c:3]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)[C:8](=O)[CH2:9][C:10]#[N:11])[CH3:12].[NH2:13][NH2:14]>CCO>[CH3:1][c:2]1[cH:3][c:4]([cH:5][c:6]([cH:7]1)-[c:8]1[cH:9][c:10]([nH:14][n:13]1)[NH2:11])[CH3:12]|US20200055842A1_1077
9.7.17|[C&H3&D1:9]-[C&H0&+0&D4:8](-[C&H3&D1:7])(-[C&H0&+0&D4:6](-[C&H3&D1:5])(-[C&H3&D1:4])-O)-O.[O&H1&+0&D1:3]-[B:2]-[O&H1&+0&D1:1]>>[C&H3&D1:9]-[C&H0&+0&D4:8]1(-[C&H3&D1:7])-[O&H0&+0&D2:1]-[B:2]-[O&H0&+0&D2:3]-[C&H0&+0&D4:6]-1(-[C&H3&D1:5])-[C&H3&D1:4]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][c:8]1[B:9]([OH:10])[OH:11])[Cl:12].[CH3:13][C:14]([CH3:15])(O)[C:16]([CH3:17])([CH3:18])O>>[CH3:13][C:14]1([O:10][B:9]([O:11][C:16]1([CH3:17])[CH3:18])[c:8]1[cH:7][c:6]([cH:5][cH:4][c:3]1[O:2][CH3:1])[Cl:12])[CH3:15]|US20110288067A1_0729
4.1.53|[C:10]-[C&H0&+0&D3:9](-[N&H1&+0&D2:8]-[N&H0&+0&D2:7]=[C&H0&+0&D3:6](-[C:5])-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:6](-[C:5]):[n&H0&+0&D2:7]:[n&H0&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][C@@H:6]1[N:7]=[C:8]([c:9]2[cH:10][c:11]([cH:12][cH:13][c:14]2[NH:15][C:16]1=[N:17][NH:18][C:19](=O)[C:20]([2H:21])([2H:22])[2H:23])[O:24][CH3:25])[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[Cl:32]>C1CCOC1.CC(=O)O.ClCCl>[CH3:25][O:24][c:11]1[cH:12][cH:13][c:14]2[c:9]([cH:10]1)[C:8](=[N:7][C@H:6]([c:16]1[n:17][n:18][c:19]([n:15]1-2)[C:20]([2H:21])([2H:22])[2H:23])[CH2:5][C:3](=[O:4])[O:2][CH3:1])[c:26]1[cH:27][cH:28][c:29]([cH:30][cH:31]1)[Cl:32]|US20200024281A1_0326
4.1.59|[N&H0&+0&D1:9]#[C&H0&+0&D2:8]-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[N&H2&+0&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:1)-[c&H0&+0&D3:5](:[c:4]):[c:3]|O.[N:1]#[C:2][CH2:3][C:4](=O)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[NH2:11][NH2:12]>CCO>[NH2:1][c:2]1[cH:3][c:4]([nH:12][n:11]1)-[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|EP2848615A1_0098
4.3.6|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D2:8]=O)=[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[c:4])-Cl.[C:3]-[C&H2&+0&D2:2]-[S&H1&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[c&H0&+0&D3:2](-[C:3]):[s&H0&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][SH:7].[O-:8][N+:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[C:17](=[O:18])[N:19]1[CH2:20][CH2:21][C:22](=[C:23]([c:24]2[cH:25][cH:26][cH:27][cH:28][c:29]21)Cl)[CH:30]=O>CN(C)C=O.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:30][c:22]2[CH2:21][CH2:20][N:19]([c:29]3[cH:28][cH:27][cH:26][cH:25][c:24]3-[c:23]2[s:7]1)[C:17](=[O:18])[c:14]1[cH:15][cH:16][c:11]([cH:12][cH:13]1)[N+:9]([O-:8])=[O:10]|US10160772B2_0203
4.3.18|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-Cl)=O.[S&H0&+0&D1:6]=[C&H0&+0&D3:5]1-[N&H1&+0&D2:4]-[C:3]-[C:2]-[N&H1&+0&D2:1]-1>>[C:10]-[C&H0&+0&D3:9]1-[N&H0&+0&D3:1]2-[C:2]-[C:3]-[N&H0&+0&D2:4]=[C&H0&+0&D3:5]-2-[S&H0&+0&D2:6]-[C&H0&+0&D3:8]=1-[C:7]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Cl)[C:7](=O)[CH:8]([CH3:9])[CH3:10].[CH3:11][C@:12]1([NH:13][C:14]([NH:15][C@@H:16]1[c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[F:23])[Cl:24])=[S:25])[c:26]1[cH:27][n:28][c:29]([cH:30][cH:31]1)[Cl:32]>CCOC(C)=O.CCO>[CH3:9][CH:8]([CH3:10])[C:7]1=[C:6]([S:25][C:14]2=[N:13][C@@:12]([C@H:16]([N:15]12)[c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[F:23])[Cl:24])([CH3:11])[c:26]1[cH:31][cH:30][c:29]([n:28][cH:27]1)[Cl:32])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|EP2103619A1_0751
4.2.3|[N&H0&+0&D1:9]#[C&H0&+0&D2:8]-Br.[N&H2&+0&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[N&H2&+0&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[o&H0&+0&D2:4]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])[C:16](=[O:17])[NH:18][NH2:19].[N:20]#[C:21]Br>C1COCCO1.O=C(O)O[Na].O>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([cH:8][c:9]([c:10]1[OH:11])[C:12]([CH3:13])([CH3:14])[CH3:15])-[c:16]1[n:18][n:19][c:21]([o:17]1)[NH2:20]|US20120101100A1_0640
4.1.8|[C:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H0&+0&D3:7](-[C:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7](-[C:6]):[c&H1&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][NH:2][c:3]1[c:4]([cH:5][c:6]([cH:7][c:8]1[Cl:9])[N+:10]([O-:11])=[O:12])[Cl:13].O=[C:14]([CH2:15][C:16](=O)[C:17]([F:18])([F:19])[F:20])[C:21]([F:22])([F:23])[F:24]>CO>[O-:11][N+:10](=[O:12])[c:6]1[cH:7][c:8]([c:3]([c:4]([cH:5]1)[Cl:13])-[n:2]1[n:1][c:14]([cH:15][c:16]1[C:17]([F:18])([F:19])[F:20])[C:21]([F:22])([F:23])[F:24])[Cl:9]|US20040248897A1_0238
4.1.48|[C:9]-[C&H0&+0&D3:8](-[C&H0&+0&D3:7](-[C:6])=[C&H1&+0&D2:5]-N(-C)-C)=O.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N&H2&+0&D1:2])-[N&H2&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H1&+0&D2:5]:[c&H0&+0&D3:7]:1-[C:6])-[N&H2&D1:1]|Cl.[CH3:1][C:2](=[O:3])[NH:4][CH:5]1[CH2:6][CH2:7][C:8]([C:9]([CH2:10]1)=[CH:11]N(C)C)=O.[NH:12]=[C:13]([NH2:14])[NH2:15]>[Na+].CC[O-].CCO>[CH3:1][C:2](=[O:3])[NH:4][CH:5]1[CH2:6][CH2:7][c:8]2[n:15][c:13]([n:12][cH:11][c:9]2[CH2:10]1)[NH2:14]|EP2536722B1_0135
4.2.16|[C:10]-[C&H0&+0&D3:9](=[O&H0&+0&D1:8])-[N&H1&+0&D2:7]-[C&H1&+0&D3:6](-[C:5])-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:10]-[c&H0&+0&D3:9]1:[o&H0&+0&D2:8]:[c&H0&+0&D3:4](:[c&H0&+0&D3:6](-[C:5]):[n&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=[O:3])[N:4]1[CH2:5][CH2:6][CH:7]([CH2:8][CH2:9]1)[C:10](=[O:11])[NH:12][CH:13]([CH2:14][OH:15])[C:16](=O)[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23]>O=C(OC(=O)C(F)(F)F)C(F)(F)F.c1ccncc1.ClCCl.O>[CH3:1][C:2](=[O:3])[N:4]1[CH2:5][CH2:6][CH:7]([CH2:8][CH2:9]1)[c:10]1[n:12][c:13]([c:16]([o:11]1)-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23])[CH2:14][OH:15]|US10745705B2_0205
4.1.19|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-[C&H0&+0&D3:6](-[C:5])=O)=O.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N&H2&+0&D1:2])-[N:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](:[n&H0&+0&D2:2]:[c&H0&+0&D3:6](-[C:5]):[c&H0&+0&D3:8]:1-[C:7])-[N:1]|[CH3:1][c:2]1[n:3][cH:4][cH:5][n:6]1-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[NH:13][C:14](=[NH:15])[NH2:16].[CH3:17][C:18]([CH3:19])([CH3:20])[O:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][C:27]([CH:28]([CH2:29]1)[C:30](=O)[CH2:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)=O>[Na+].CC[O-].CCO>[CH3:1][c:2]1[n:3][cH:4][cH:5][n:6]1-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[NH:13][c:14]1[n:15][c:27]2[CH2:26][CH2:25][N:24]([CH2:29][c:28]2[c:30]([n:16]1)[CH2:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)[C:22](=[O:23])[O:21][C:18]([CH3:17])([CH3:19])[CH3:20]|US08188101B2_1284
4.1.8|[C:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](-[C:7])=O)-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[c&H0&+0&D3:8](-[C:7]):[n&H1&+0&D2:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:6]:1-[c&H0&+0&D3:5](:[c:4]):[c:3]|O.[NH2:1][NH2:2].[O-:3][N+:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[C:12](=O)[CH:13]1[C:14]([CH2:15][CH2:16][CH2:17][C:18]1=O)=[O:19]>CCO>[O-:3][N+:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1-[c:12]1[n:1][nH:2][c:18]2[CH2:17][CH2:16][CH2:15][C:14]([c:13]12)=[O:19]|US20200262827A1_0333
4.2.3|[N&H2&+0&D1:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](=[O&H0&+0&D1:6])-[c&H0&+0&D3:5](:[c:4]):[c:3].[S&H0&+0&D1:2]=[C&H0&+0&D2:1]=S>>[n&H0&+0&D2:9]1:[c&H0&+0&D3:1](:[o&H0&+0&D2:6]:[c&H0&+0&D3:7](:[n&H0&+0&D2:8]:1)-[c&H0&+0&D3:5](:[c:4]):[c:3])-[S&H1&+0&D1:2]|[NH2:1][NH:2][C:3](=[O:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][c:10]1[N+:11]([O-:12])=[O:13].[S:14]=[C:15]=S>O.Cl.c1ccncc1>[O-:12][N+:11](=[O:13])[c:10]1[cH:9][cH:8][cH:7][cH:6][c:5]1-[c:3]1[n:2][n:1][c:15]([o:4]1)[SH:14]|US20190308947A1_0178
4.1.8|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O)=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:6](:[c&H0&+0&D3:8]:1-[C:7])-[c&H0&+0&D3:5](:[c:4]):[c:3]|O.[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH:7]([CH2:8][CH3:9])[C:10](=O)[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17].[NH2:18][NH2:19]>CCO>[CH3:9][CH2:8][c:7]1[c:6]([n:18][nH:19][c:10]1-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20050277630A1_0762
4.3.3|[C:10]-[C&H0&+0&D3:9](-[N&H2&+0&D1:8])=[S&H0&+0&D1:7].[c:6]:[c&H0&+0&D3:5]1:[c:4]-[C:3]-[C&H1&+0&D3:2](-[C&H0&+0&D3:1]-1=O)-Br>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:1]2:[c&H0&+0&D3:2](:[s&H0&+0&D2:7]:1)-[C:3]-[c:4]:[c&H0&+0&D3:5]-2:[c:6]|Cl.[NH2:1][C:2](=[S:3])[CH2:4][c:5]1[cH:6][nH:7][cH:8][n:9]1.O=[C:10]1[c:11]2[cH:12][cH:13][cH:14][cH:15][c:16]2[CH2:17][CH:18]1Br>CC(C)O>[cH:8]1[n:9][c:5]([cH:6][nH:7]1)[CH2:4][c:2]1[n:1][c:10]2-[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3[CH2:17][c:18]2[s:3]1|US06329407B1
4.3.3|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])-Cl)=O.[C:4]-[C&H0&+0&D3:3](-[N&H2&+0&D1:2])=[S&H0&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:2]:[c&H0&+0&D3:3](-[C:4]):[s&H0&+0&D2:1]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][O:2][C:3](=[O:4])[C:5](=O)[CH:6](Cl)[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1.[NH2:13][C:14](=[S:15])[CH:16]1[CH2:17][CH2:18]1>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:13][c:14]([s:15][c:6]1-[c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[CH:16]1[CH2:17][CH2:18]1|US20110039857A1_0223
4.3.3|[C:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](-[C:7])=O)-Cl.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[s&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[C:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][CH2:3][C:4](=O)[CH:5](Cl)[C:6](=[O:7])[O:8][CH3:9].[NH2:10][C:11](=[S:12])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>CCO>[CH3:9][O:8][C:6](=[O:7])[c:5]1[s:12][c:11]([n:10][c:4]1[CH2:3][O:2][CH3:1])-[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|US10626095B2_2661
4.1.45|[c:11]:[c&H0&+0&D3:10](:[c:9])-[C&H1&+0&D2:8]=O.[c:7]:[c&H0&+0&D3:6](:[c:5])-[N&H1&+0&D2:4]-[c:3]:[c:2]-[N&H0&+&D3:1](-[O&-])=O>>[c:11]:[c&H0&+0&D3:10](:[c:9])-[c&H0&+0&D3:8]1:[n&H0&+0&D3:4](:[c:3]:[c:2]:[n&H0&+0&D2:1]:1)-[c&H0&+0&D3:6](:[c:7]):[c:5]|[NH2:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1[CH:8]=O.[O-][N+:9](=O)[c:10]1[cH:11][cH:12][cH:13][n:14][c:15]1[NH:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>[Na+].[Na+].CS(C)=O.CO.[O-]S(=O)S([O-])=O.ClCCl>[NH2:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]2[cH:11][cH:12][cH:13][n:14][c:15]2[n:16]1-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US20200347059A1_0244
4.1.14|[N&H4&+&D0:10].[C:9]-[C&H0&+0&D3:8](-[C&H1&+0&D3:7](-[C:6])-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)=O>>[n&H1&+0&D2:10]1:[c&H0&+0&D3:8](-[C:9]):[c&H0&+0&D3:7](-[C:6]):[c&H1&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH4+:1].[CH3:2][CH2:3][O:4][C:5](=[O:6])[CH:7]([CH2:8][C:9](=O)[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[O:16][CH2:17][CH:18]1[CH2:19][CH2:20]1)[O:21][CH:22]([F:23])[F:24])[C:25](=O)[CH2:26][O:27][CH2:28][c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[O:35][CH3:36].CC([O-])=O>O.CCO>[CH3:2][CH2:3][O:4][C:5](=[O:6])[c:7]1[cH:8][c:9]([nH:1][c:25]1[CH2:26][O:27][CH2:28][c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[O:35][CH3:36])-[c:10]1[cH:11][cH:12][c:13]([c:14]([cH:15]1)[O:16][CH2:17][CH:18]1[CH2:19][CH2:20]1)[O:21][CH:22]([F:23])[F:24]|US09394297B2_2235
4.3.3|[C:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[n:5])=O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[n:5])-[N:2]|[CH3:1][CH:2]([c:3]1[cH:4][cH:5][c:6]([n:7][cH:8]1)[C:9]([F:10])([F:11])[F:12])[S:13]([CH3:14])(=[O:15])=[N:16][C:17]([NH2:18])=[S:19].O=[C:20]1[c:21]2[n:22][o:23][n:24][c:25]2[CH2:26][CH2:27][CH:28]1Br>CCO>[CH3:1][CH:2]([c:3]1[cH:8][n:7][c:6]([cH:5][cH:4]1)[C:9]([F:10])([F:11])[F:12])[S:13]([CH3:14])(=[O:15])=[N:16][c:17]1[n:18][c:20]2-[c:21]3[n:22][o:23][n:24][c:25]3[CH2:26][CH2:27][c:28]2[s:19]1|US20190241552A1_0181
4.3.3|[C:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5])-[N:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][O:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[C:13]([CH:14]([CH2:15][CH2:16][c:17]12)Br)=O.[NH2:18][C:19](=[S:20])[NH:21][CH2:22][CH2:23][CH:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1>CCN(CC)CC.CC#N.O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][O:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[c:17]1[CH2:16][CH2:15][c:14]1[s:20][c:19]([n:18][c:13]-21)[NH:21][CH2:22][CH2:23][CH:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[c:31]1[cH:36][cH:35][cH:34][cH:33][cH:32]1|US20130252944A1_0582
4.3.3|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-Br)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[s&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[C:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][CH:3](Br)[C:4](=O)[C:5]([CH3:6])([CH3:7])[C:8](=[O:9])[O:10][CH3:11].[NH2:12][C:13](=[S:14])[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[C:21]([F:22])([F:23])[F:24]>CCO>[CH3:1][CH2:2][c:3]1[s:14][c:13]([n:12][c:4]1[C:5]([CH3:6])([CH3:7])[C:8](=[O:9])[O:10][CH3:11])-[c:15]1[cH:20][cH:19][c:18]([cH:17][cH:16]1)[C:21]([F:22])([F:23])[F:24]|US20100009969A1_0646
4.1.48|[C&H3&D1:9]-[C&H0&+0&D3:8](=[N&H1&+0&D1:7])-[N&H2&+0&D1:6].[C:5]-[C&H0&+0&D3:4](-[C&H0&+0&D3:3](-[C:2])=[C&H1&+0&D2:1]-N(-C)-C)=O>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[c&H1&+0&D2:1]:[c&H0&+0&D3:3](-[C:2]):[c&H0&+0&D3:4](-[C:5]):[n&H0&+0&D2:6]:1|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([C:12]([CH2:13]1)=[CH:14]N(C)C)=O.[CH3:15][C:16](=[NH:17])[NH2:18].CC(=O)O>>[CH3:15][c:16]1[n:18][c:11]2[CH2:10][CH2:9][N:8]([CH2:13][c:12]2[cH:14][n:17]1)[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4]|US20140309244A1_0646
3.11.3|[C&H2&+0&D1:9]=[C&H1&+0&D2:8]-[C:7].[C&H2&+0&D1:6]=[C&H0&+0&D3:5](-[C&H3&D1:4])-[C&H0&+0&D3:3](=[C&H2&+0&D1:2])-[C&H3&D1:1]>>[C&H2&+0&D2:9]1-[C&H2&+0&D2:6]-[C&H0&+0&D3:5](-[C&H3&D1:4])=[C&H0&+0&D3:3](-[C&H2&+0&D2:2]-[C&H1&+0&D3:8]-1-[C:7])-[C&H3&D1:1]|[CH2:1]=[C:2]([CH3:3])[C:4](=[CH2:5])[CH3:6].[CH2:7]=[CH:8][C:9](=[O:10])[CH2:11][CH:12]([CH3:13])[CH3:14]>>[CH3:3][C:2]1[CH2:1][CH2:7][CH:8]([CH2:5][C:4]=1[CH3:6])[C:9](=[O:10])[CH2:11][CH:12]([CH3:13])[CH3:14]|US09303232B2_0151
4.1.9|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-[C&H0&+0&D3:6](=[O&H0&D1:5])-[N&H1&+0&D2:4]-[c:3]:[c&H1&+0&D2:2]:[c:1])=O>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[c&H0&+0&D3:2](:[c:1]):[c:3]:[n&H1&+0&D2:4]:[c&H0&+0&D3:6](=[O&H0&D1:5]):[c&H0&+0&D3:8]:1-[C:7]|[CH3:1][C:2](=O)[CH:3]([CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11])[C:12](=[O:13])[NH:14][c:15]1[cH:16][c:17]([cH:18][cH:19][c:20]1[F:21])[OH:22]>>[CH3:1][c:2]1[c:3]([c:12]([nH:14][c:15]2[c:16]1[c:17]([cH:18][cH:19][c:20]2[F:21])[OH:22])=[O:13])[CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11]|US08173812B2_0388
4.3.3|[C:10]-[C&H0&+0&D3:9](-[N&H2&+0&D1:8])=[S&H0&+0&D1:7].[C:6]-[C&H1&+0&D3:5](-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)-Br>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:4](:[c&H0&+0&D3:5](-[C:6]):[s&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|Cl.[CH3:1][CH:2]1[CH2:3][CH:4]([C:5]([c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21)=O)Br.[NH2:12][C:13](=[S:14])[CH2:15][c:16]1[cH:17][nH:18][cH:19][n:20]1>>[CH3:1][CH:2]1[CH2:3][c:4]2[s:14][c:13]([n:12][c:5]2-[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21)[CH2:15][c:16]1[cH:17][nH:18][cH:19][n:20]1|US20080119456A1_0176
4.1.72|[N&H2&+0&D1:10]-[c:9]:[n&H1&+0&D2:8]:[n:7].[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:10]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D3:8](:[n:7]):[c:9]:1)-[c&H0&+0&D3:5](:[c:6]):[c:4]|CN(C)[CH:1]=[CH:2][C:3](=O)[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[C:10]([F:11])([F:12])[F:13].[CH3:14][c:15]1[n:16][nH:17][c:18]([c:19]1[C:20]#[N:21])[NH2:22]>CC(=O)O>[CH3:14][c:15]1[n:16][n:17]2[c:3]([cH:2][cH:1][n:22][c:18]2[c:19]1[C:20]#[N:21])-[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[C:10]([F:11])([F:12])[F:13]|US20100029657A1_0222
3.11.34|[C:11]-[C&H2&+0&D2:10]-[C&H0&+0&D3:9](=[O&H0&D1:8])-[N&H1&+0&D2:7]-[c:6]:[c:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:11]-[c&H0&+0&D3:10]1:[c&H0&+0&D3:4](:[c:5]:[c:6]:[n&H1&+0&D2:7]:[c&H0&+0&D3:9]:1=[O&H0&D1:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=[O:8])[NH:9][c:10]1[s:11][c:12]([cH:13][c:14]1[C:15](=O)[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[Cl:22])[CH2:23][CH3:24]>Cc1ccccc1.C1CN=C2CCCCCN2C1>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:15]([c:14]2[cH:13][c:12]([s:11][c:10]2[nH:9][c:7]1=[O:8])[CH2:23][CH3:24])-[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[Cl:22]|EP0472116A1_0075
4.1.63|[C:11]-[C&H2&+0&D2:10]-[C&H0&+0&D3:9](=[O&H0&D1:8])-O.[N&H2&+0&D1:7]-[c:6]:[c:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:11]-[c&H0&+0&D3:10]1:[c&H0&+0&D3:4](:[c:5]:[c:6]:[n&H1&+0&D2:7]:[c&H0&+0&D3:9]:1=[O&H0&D1:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][c:2]1[c:3]([cH:4][c:5]([cH:6][c:7]1[F:8])[Cl:9])[C:10](=O)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[N:17]#[C:18][CH2:19][C:20](=[O:21])O>Cc1ccccc1.CCN(CC)CC.CN(C)C=O.C(C#[O+])#[O+].ClCCl.O.[Cl-].[Cl-]>[N:17]#[C:18][c:19]1[c:10]([c:3]2[cH:4][c:5]([cH:6][c:7]([c:2]2[nH:1][c:20]1=[O:21])[F:8])[Cl:9])-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|US09199938B2_0777
4.1.29|[C&H3&D1:11]-[C&H0&+0&D3:10](-[C&H2&+0&D2:9]-[C:8])=O.[N&H2&+0&D1:7]-[c:6]:[c:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C&H3&D1:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D2:7]:[c:6]:[c:5]:[c&H0&+0&D3:4](:[c&H0&+0&D3:9]:1-[C:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7]([CH3:8])=O.[NH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[C:16](=O)[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23])[Cl:24]>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[c:16]([c:15]2[cH:14][c:13]([cH:12][cH:11][c:10]2[n:9][c:7]1[CH3:8])[Cl:24])-[c:17]1[cH:22][cH:21][c:20]([cH:19][cH:18]1)[F:23]|US20120316161A1_0469
4.2.3|[C&H3&D1:9]-[C&H0&+0&D4:8](-O-C)(-O-C)-O-C.[N&H2&+0&D1:7]-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:7]:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[o&H0&+0&D2:4]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|CO[C:1]([CH3:2])(OC)OC.[NH2:3][NH:4][C:5](=[O:6])[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[N+:13]([O-:14])=[O:15]>>[CH3:2][c:1]1[n:3][n:4][c:5]([o:6]1)-[c:7]1[cH:12][cH:11][c:10]([cH:9][cH:8]1)[N+:13]([O-:14])=[O:15]|US20060194969A1_0487
4.1.62|[C:11]-[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-[c:8]:[c:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:6](=[O&H0&D1:5]):[c:7]:[c:8]:[n&H0&+0&D2:9]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH:8][C:9](=[O:10])[c:11]1[cH:12][c:13]([cH:14][cH:15][c:16]1[NH:17][C:18](=O)[CH2:19][F:20])[N+:21]([O-:22])=[O:23]>O.O.CC(=O)OC(C)=O.CC(=O)O.O=C(O[K])O[K]>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1-[n:8]1[c:9]([c:11]2[cH:12][c:13]([cH:14][cH:15][c:16]2[n:17][c:18]1[CH2:19][F:20])[N+:21]([O-:22])=[O:23])=[O:10]|US20190224197A1_0623
4.2.4|[C&H3&D1:10]-[C&H0&+0&D2:9]#[C&H0&+0&D2:8]-[C:7].[O&H1&+0&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Cl>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[o&H0&+0&D2:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4](:[c&H0&+0&D3:8]:1-[C:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[OH:1][N:2]=[C:3](Cl)[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[F:10].[CH3:11][C:12]#[C:13][C:14](=[O:15])[O:16][CH3:17]>CCN(CC)CC.CCOCC>[CH3:17][O:16][C:14](=[O:15])[c:13]1[c:3]([n:2][o:1][c:12]1[CH3:11])-[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[F:10]|EP2792360A1_0168
4.1.85|[C:11]-[C&H0&+0&D2:10]#[C&H0&+0&D2:9]-[c&H0&+0&D3:8](:[c:7]):[c:6].[N&H2&+0&D1:5]-[n&H0&+&D3:4](:[c:3]):[c&H1&+0&D2:2]:[c:1]>>[C:11]-[c&H0&+0&D3:10]1:[c&H0&+0&D3:9](:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2]:1:[c:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[I-].[CH3:1][O:2][C:3](=[O:4])[C:5]#[C:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[F:13].[NH2:14][n+:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>CC#N.C1CCCCCN(CCCN=1)C1CCCCCCCCCC1>[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]([n:14][n:15]2[cH:20][cH:19][cH:18][cH:17][c:16]12)-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[F:13]|US07585875B2_0350
4.3.3|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N:2]):[s&H0&+0&D2:1]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[CH2:9][C:10]([CH3:11])=O.[CH3:12][C:13](=[O:14])[NH:15][C:16]([NH2:17])=[S:18]>II.c1ccncc1>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[s:18][c:16]([n:17][c:10]1[CH3:11])[NH:15][C:13]([CH3:12])=[O:14]|US08404684B2_0206
4.1.30|[N&H2&+0&D1:11]-[c:10]:[c:9]-[C&H0&+0&D3:8](=[O&H0&D1:7])-O.[c:6]:[c&H0&+0&D3:5]1-[N&H1&+0&D2:4]-[C&H0&+0&D3:3](-[C:2]-[c:1]:1)=O>>[n&H0&+0&D2:11]1:[c:10]:[c:9]:[c&H0&+0&D3:8](=[O&H0&D1:7]):[n&H0&+0&D3:4]2:[c&H0&+0&D3:3]:1-[C:2]-[c:1]:[c&H0&+0&D3:5]-2:[c:6]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[NH:7][C:8]([C:9]([c:10]2[cH:11]1)=[O:12])=O.[NH2:13][c:14]1[n:15][cH:16][cH:17][cH:18][c:19]1[C:20](=[O:21])O>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:10]([cH:11]1)[C:9]([c:8]1[n:13][c:14]3[n:15][cH:16][cH:17][cH:18][c:19]3[c:20]([n:7]1-2)=[O:21])=[O:12]|
4.3.3|[C:10]-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5])-[N&H2&D1:2]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][C:7](=O)[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1.[NH2:14][C:15]([NH2:16])=[S:17]>Cc1ccc(cc1)S(=O)(=O)Oc1c(cccc1I)O.CC#N>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[s:17][c:15]([n:16][c:7]1-[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[NH2:14]|US20200369676A1_0811
4.1.99|[C:10]-[C&H0&+0&D3:9](-[N&H1&+0&D2:8]-[N&H2&+0&D1:7])=O.[S&H0&D1:6]=[C&H0&+0&D2:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:5](:[n&H1&+0&D2:7]:[n&H0&+0&D2:8]:1)=[S&H0&D1:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[N:10]=[C:11]=[S:12].[NH2:13][NH:14][C:15](=O)[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[Cl:23]>>[CH3:1][CH2:2][O:3][c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1-[n:10]1[c:15]([n:14][nH:13][c:11]1=[S:12])[CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][c:22]1[Cl:23]|US20070093483A1_1016
4.2.16|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[o&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[C:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]([NH:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17])[C:18]([CH3:19])=O>CN(C)C=O.O=P(Cl)(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[n:8][c:9]([o:10][c:18]1[CH3:19])-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]|US08987311B2_0384
4.1.53|[C&H3&D1:10]-[C&H0&+0&D3:9](-[N&H1&+0&D2:8]-[N&H0&+0&D2:7]=[C&H0&+0&D3:6](-[C:5])-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:6](-[C:5]):[n&H0&+0&D2:7]:[n&H0&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=O)[NH:3][N:4]=[C:5]1[CH2:6][N:7]=[C:8]([13C:9]2=[13C:10][13C:11](=[13C:12][13C:13]=[13C:14]2[NH:15]1)[Cl:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>>[CH3:1][c:2]1[n:3][n:4][c:5]2[CH2:6][N:7]=[C:8]([13C:9]3=[13C:10][13C:11](=[13C:12][13C:13]=[13C:14]3[n:15]12)[Cl:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US09884874B2_0175
4.1.8|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H0&+0&D3:7](-[C:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[c&H0&+0&D3:7](-[C:6]):[n&H0&+0&D2:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|Cl.[CH3:1][C:2](=O)[CH2:3][C:4](=O)[C:5]([F:6])([F:7])[F:8].[CH3:9][O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[NH:17][NH2:18]>COCCO.CC(=O)O>[CH3:9][O:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)-[n:17]1[n:18][c:4]([cH:3][c:2]1[CH3:1])[C:5]([F:6])([F:7])[F:8]|US20200131157A1_0182
4.1.62|[C:9]-[C&H0&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-O-C)=O.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N&H2&+0&D1:2])-[N&H2&D1:1]>>[C:9]-[c&H0&+0&D3:8]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](:[n&H1&+0&D2:2]:[c&H0&+0&D3:6](=[O&H0&D1:5]):[c&H1&+0&D2:7]:1)-[N&H2&D1:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=O)[CH2:6][C:7](=[O:8])OC.[NH:9]=[C:10]([NH2:11])[NH2:12].O=C(O)O>CCO>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([nH:12][c:10]([n:9]1)[NH2:11])=[O:8]|US07923451B2_0242
9.7.261|[C&H3&D1:10]-[#14&H0&+0&D4:9](-[C&H3&D1:8])(-[C&H3&D1:7])-[C&H0&+0&D2:6]#[N&H0&D1:5].[C:4]-[C&H0&+0&D3:3](=[O&H0&+0&D1:2])-[c:1]>>[C&H3&D1:10]-[#14&H0&+0&D4:9](-[C&H3&D1:8])(-[C&H3&D1:7])-[O&H0&+0&D2:2]-[C&H0&+0&D4:3](-[C:4])(-[c:1])-[C&H0&+0&D2:6]#[N&H0&D1:5]|[O:1]=[C:2]1[CH2:3][CH2:4][CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[CH3:12][Si:13]([CH3:14])([CH3:15])[C:16]#[N:17]>CCOCC.I[Zn]I>[CH3:12][Si:13]([CH3:14])([CH3:15])[O:1][C:2]1([CH2:3][CH2:4][CH2:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21)[C:16]#[N:17]|US20200377460A1_0685
9.7.261|[C&H3&D1:10]-[#14&H0&+0&D4:9](-[C&H3&D1:8])(-[C&H3&D1:7])-[C&H0&+0&D2:6]#[N&H0&D1:5].[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&D1:10]-[#14&H0&+0&D4:9](-[C&H3&D1:8])(-[C&H3&D1:7])-[O&H0&+0&D2:1]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C&H0&+0&D2:6]#[N&H0&D1:5]|[O:1]=[C:2]1[CH:3]2[CH2:4][CH:5]3[CH2:6][C:7]([CH2:8][CH:9]1[CH2:10]3)([CH2:11]2)[O:12][CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)-[c:20]1[n:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[o:28]1.[CH3:29][Si:30]([CH3:31])([CH3:32])[C:33]#[N:34]>ClCCl.I[Zn]I>[CH3:29][Si:30]([CH3:31])([CH3:32])[O:1][C:2]1([CH:3]2[CH2:4][CH:5]3[CH2:6][C:7]([CH2:8][CH:9]1[CH2:10]3)([CH2:11]2)[O:12][CH2:13][c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)-[c:20]1[n:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[o:28]1)[C:33]#[N:34]|US20190382350A1_0205
4.1.62|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-[C&H0&+0&D3:6](-[O&H0&+0&D2:5]-C)=O)=O.[N&H2&+0&D1:4]-[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[n:1]):[c&H0&+0&D3:6](-[O&H1&+0&D1:5]):[c&H0&+0&D3:8]:1-[C:7]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][CH:6]([C:7]([CH3:8])=O)[C:9](=O)[O:10]C.[NH2:11][c:12]1[cH:13][c:14]([n:15][nH:16]1)[Br:17]>O.Cc1ccccc1C.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[c:7]([n:11][c:12]2[cH:13][c:14]([n:15][n:16]2[c:9]1[OH:10])[Br:17])[CH3:8]|EP2970301B1_0076
4.1.62|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-[C&H0&+0&D3:6](-[O&H0&+0&D2:5]-C)=O)=O.[N&H2&+0&D1:4]-[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H1&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[n:1]):[c&H0&+0&D3:6](=[O&H0&+0&D1:5]):[c&H0&+0&D3:8]:1-[C:7]|[CH3:1][C:2](=O)[CH:3]([C:4](=O)[O:5]C)[CH:6]([CH3:7])[CH3:8].[CH3:9][c:10]1[cH:11][c:12]([nH:13][n:14]1)[NH2:15]>>[CH3:7][CH:6]([CH3:8])[c:3]1[c:2]([nH:15][c:12]2[cH:11][c:10]([n:14][n:13]2[c:4]1=[O:5])[CH3:9])[CH3:1]|US09505767B2_0308
4.1.59|[C:10]-[N&H1&+0&D2:9]-[N&H2&+0&D1:8].[N&H0&+0&D1:7]#[C&H0&+0&D2:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:10]-[n&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:4](:[c&H1&+0&D2:5]:[c&H0&+0&D3:6]:1-[N&H2&+0&D1:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|Cl.[N:1]#[C:2][CH2:3][C:4](=O)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[NH2:11][C:12](=[O:13])[NH:14][NH2:15]>[Na+].CCO.C[O-]>[NH2:11][C:12](=[O:13])[n:14]1[n:15][c:4]([cH:3][c:2]1[NH2:1])-[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1|EP2807162B1_0183
4.1.8|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[c:4])=O)=O.[C:3]-[N&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:1]:[n&H0&+0&D3:2](-[C:3]):[c&H0&+0&D3:7](:[c&H1&+0&D2:8]:1)-[c&H0&+0&D3:6](:[c:5]):[c:4]|Cl.[CH3:1][C:2](=O)[CH2:3][C:4](=O)[c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[N+:11]([O-:12])=[O:13])[Br:14].[NH2:15][NH:16][CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21]1>CC(=O)O>[CH3:1][c:2]1[cH:3][c:4]([n:16]([n:15]1)[CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21]1)-[c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[N+:11]([O-:12])=[O:13])[Br:14]|US20100094000A1_1806
3.11.3|[C&H2&+0&D1:11]=[C&H1&+0&D2:10]-[C:9].[C:8]-[C&H0&+0&D3:7]1=[C&H1&+0&D2:6]-[C&H1&+0&D2:5]=[C&H0&+0&D3:4](-[O:3])-[C:2]-[C:1]-1>>[C&H2&+0&D2:11]1-[C&H1&+0&D3:10](-[C:9])-[C&H0&+0&D4:4]2(-[O:3])-[C&H1&+0&D2:5]=[C&H1&+0&D2:6]-[C&H0&+0&D4:7]-1(-[C:8])-[C:1]-[C:2]-2|[CH2:1]=[CH:2][C:3]([CH3:4])=[O:5].[CH3:6][O:7][C:8]1=[CH:9][CH:10]=[C:11]2[CH:12]3[CH2:13][c:14]4[cH:15][cH:16][c:17]([c:18]5[O:19][CH:20]1[C:21]2([CH2:22][CH2:23][N:24]3[CH3:25])[c:26]54)[O:27][CH3:28]>>[CH3:4][C:3](=[O:5])[CH:2]1[CH2:1][C:11]23[CH:10]=[CH:9][C:8]1([CH:20]1[O:19][c:18]4[c:17]([cH:16][cH:15][c:14]5[CH2:13][CH:12]3[N:24]([CH2:23][CH2:22][C:21]12[c:26]45)[CH3:25])[O:27][CH3:28])[O:7][CH3:6]|
4.1.14|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O)=O.[C:2]-[N&H2&+0&D1:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D3:1](-[C:2]):[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:[c&H1&+0&D2:8]:1)-[c&H0&+0&D3:5](:[c:4]):[c:3]|[CH3:1][C:2](=O)[CH2:3][CH2:4][C:5](=O)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:12]([CH3:13])(=[O:14])=[O:15].[NH2:16][CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1>Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:13][S:12](=[O:14])(=[O:15])[c:9]1[cH:10][cH:11][c:6]([cH:7][cH:8]1)-[c:5]1[cH:4][cH:3][c:2]([n:16]1[CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)[CH3:1]|EP1284260A1_0440
4.2.10|[C:10]-[C&H2&+0&D2:9]-[C&H0&+0&D2:8]#[N&H0&+0&D1:7].[O&H1&+0&D1:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:10]-[c&H0&+0&D3:9]1:[c&H0&+0&D3:8](-[N&H2&+0&D1:7]):[o&H0&+0&D2:6]:[c&H1&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=O)[CH2:10][OH:11].[N:12]#[C:13][CH2:14][C:15]#[N:16]>O.CCNCC.CN(C)C=O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][o:11][c:15]([c:14]1[C:13]#[N:12])[NH2:16]|US10626122B2_0570
4.3.3|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])-Cl)=O.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](-[N&H2&D1:2]):[s&H0&+0&D2:1]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[CH:8](Cl)[C:9](=O)[C:10](=[O:11])[O:12][CH3:13].[NH2:14][C:15]([NH2:16])=[S:17]>>[CH3:13][O:12][C:10](=[O:11])[c:9]1[n:16][c:15]([s:17][c:8]1-[c:6]1[cH:5][cH:4][cH:3][c:2]([cH:7]1)[CH3:1])[NH2:14]|US08288429B2_0156
4.3.3|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C:7])-Cl)=O.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[s&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[C:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][c:7]([c:8]1[O:9][CH3:10])[O:11][CH3:12])[C:13]([NH2:14])=[S:15].[CH3:16][C:17](=O)[CH:18](Cl)[C:19]([CH3:20])=[O:21]>c1ccccc1>[CH3:10][O:9][c:8]1[c:3]([cH:4][c:5]([cH:6][c:7]1[O:11][CH3:12])-[c:13]1[n:14][c:17]([c:18]([s:15]1)[C:19]([CH3:20])=[O:21])[CH3:16])[O:2][CH3:1]|EP3409276B1_0966
4.3.3|[C&H3&D1:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](-[C:7])=O)-Br.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[s&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[C:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH2:5][C:6](=O)[CH:7]([CH3:8])Br.[NH2:9][C:10](=[S:11])[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>>[CH3:1][O:2][C:3](=[O:4])[CH2:5][c:6]1[n:9][c:10]([s:11][c:7]1[CH3:8])-[c:12]1[cH:17][cH:16][cH:15][cH:14][cH:13]1|US20050288340A1_0755
4.3.3|[C:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5])-[N&H2&D1:2]|[NH2:1][C:2]([NH2:3])=[S:4].[O:5]=[C:6]1[c:7]2[cH:8][cH:9][cH:10][cH:11][c:12]2[C:13]([N:14]1[CH2:15][CH:16](Br)[C:17](=O)[c:18]1[cH:19][cH:20][c:21]([cH:22][c:23]1[C:24](=[O:25])[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[Cl:32])=[O:33]>O.CCO>[NH2:1][c:2]1[n:3][c:17]([c:16]([s:4]1)[CH2:15][N:14]1[C:13]([c:12]2[cH:11][cH:10][cH:9][cH:8][c:7]2[C:6]1=[O:5])=[O:33])-[c:18]1[cH:19][cH:20][c:21]([cH:22][c:23]1[C:24](=[O:25])[c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[Cl:32]|EP3556756A1_0112
4.3.3|[C&H3&D1:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N:2])=[S&H0&+0&D1:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5])-[N:2]|[CH3:1][CH:2](Br)[C:3](=O)[c:4]1[cH:5][cH:6][c:7]2[NH:8][C:9]([CH2:10][CH2:11][c:12]2[cH:13]1)=[O:14].[NH:15]=[C:16]([NH2:17])[NH:18][C:19]([NH2:20])=[S:21]>CCO>[CH3:1][c:2]1[s:21][c:19]([n:20][c:3]1-[c:4]1[cH:5][cH:6][c:7]2[NH:8][C:9]([CH2:10][CH2:11][c:12]2[cH:13]1)=[O:14])[NH:18][C:16](=[NH:15])[NH2:17]|US20110105436A1_0682
3.11.3|[C:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[c&H1&+0&D2:7]:[c&H1&+0&D2:6]:[o&H0&+0&D2:5]:1.[C:4]-[C&H1&+0&D2:3]=[C&H1&+0&D2:2]-[C:1]>>[C:10]-[C&H0&+0&D4:9]12-[C&H1&+0&D3:3](-[C:4])-[C&H1&+0&D3:2](-[C:1])-[C&H1&+0&D3:6](-[C&H1&+0&D2:7]=[C&H1&+0&D2:8]-1)-[O&H0&+0&D2:5]-2|[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[CH3:8])[CH:9]1[C:10]([CH:11]=[CH:12][C:13]1=[O:14])=[O:15])[CH3:16].[OH:17][CH2:18][c:19]1[cH:20][cH:21][cH:22][o:23]1>I[Mg]I>[CH3:1][c:2]1[cH:3][c:4]([c:5]([c:6]([cH:7]1)[CH3:8])[CH:9]1[C:10]([CH:11]2[CH:22]3[CH:21]=[CH:20][C:19]([O:23]3)([CH:12]2[C:13]1=[O:14])[CH2:18][OH:17])=[O:15])[CH3:16]|US20110184188A1_1211
4.1.58|[N&H2&+0&D1:11]-[c:10]:[c:9]-[N&H2&+0&D1:8].[c:7]:[c&H0&+0&D3:6]1:[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H0&+0&D3:1]-1=O)=O>>[n&H0&+0&D2:11]1:[c:10]:[c:9]:[n&H0&+0&D2:8]:[c&H0&+0&D3:1]2:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:3]):[c:5]:[c&H0&+0&D3:6]-2:[c:7]|[NH2:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[NH2:8])[Cl:9].O=[C:10]1[C:11]([c:12]2[cH:13][cH:14][cH:15][c:16]3[cH:17][cH:18][cH:19][c:20]1[c:21]23)=O>>[Cl:9][c:4]1[cH:5][cH:6][c:7]2[n:8][c:10]3-[c:20]4[cH:19][cH:18][cH:17][c:16]5[cH:15][cH:14][cH:13][c:12](-[c:11]3[n:1][c:2]2[cH:3]1)[c:21]54|US20090059370A1_0089
4.2.3|[N&H2&+0&D1:10]-[N&H1&+0&D2:9]-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[c&H0&+0&D3:6](:[c:5]):[c:4].[c:3]-[N&H0&+0&D2:2]=[C&H0&+0&D2:1]=S>>[n&H0&+0&D2:10]1:[c&H0&+0&D3:1](:[o&H0&+0&D2:7]:[c&H0&+0&D3:8](:[n&H0&+0&D2:9]:1)-[c&H0&+0&D3:6](:[c:5]):[c:4])-[N&H1&+0&D2:2]-[c:3]|[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][c:7]([cH:8][cH:9][c:10]1[Cl:11])[N:12]=[C:13]=S.[NH2:14][NH:15][C:16](=[O:17])[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[OH:24]>CCOC(C)=O.CO.CO.O=[Hg]>[OH:24][c:21]1[cH:20][cH:19][c:18]([cH:23][cH:22]1)-[c:16]1[n:15][n:14][c:13]([o:17]1)[NH:12][c:7]1[cH:8][cH:9][c:10]([c:5]([cH:6]1)[C:2]([F:1])([F:3])[F:4])[Cl:11]|US20090318438A1_0920
4.1.59|[C:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H0&+0&D2:7]#[N&H0&+0&D1:6])=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7](-[N&H2&+0&D1:6]):[c&H1&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[C:5](=O)[CH2:6][C:7]#[N:8].[NH2:9][NH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O.CCO.CC(=O)O>[CH3:1][C:2]([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([n:10]([n:9]1)-[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1)[NH2:8]|EP2370429B1_0242
4.3.3|[C&H3&D1:10]-[C&H0&+0&D3:9](-[N&H2&+0&D1:8])=[S&H0&+0&D1:7].[C:6]-[C&H1&+0&D3:5](-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)-Cl>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:4](:[c&H0&+0&D3:5](-[C:6]):[s&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6](Cl)[C:7](=O)[c:8]1[cH:9][c:10]([cH:11][cH:12][cH:13]1)[F:14].[CH3:15][C:16]([NH2:17])=[S:18]>>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[s:18][c:16]([n:17][c:7]1-[c:8]1[cH:13][cH:12][cH:11][c:10]([cH:9]1)[F:14])[CH3:15]|US20110212968A1_1084
4.3.3|[C&H3&D1:10]-[C&H0&+0&D3:9](-[N&H2&+0&D1:8])=[S&H0&+0&D1:7].[C:6]-[C&H0&+0&D3:5](-[C&H1&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Cl)=O>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:5](-[C:6]):[c&H0&+0&D3:4](:[s&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([NH2:3])=[S:4].[CH3:5][O:6][C:7](=[O:8])[C:9](=O)[CH:10](Cl)[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[CH3:17]>>[CH3:5][O:6][C:7](=[O:8])[c:9]1[n:3][c:2]([s:4][c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[CH3:17])[CH3:1]|EP2079690B1_0070
4.3.3|[C&H3&D1:10]-[C&H0&+0&D3:9](-[N&H2&+0&D1:8])=[S&H0&+0&D1:7].[C:6]-[C&H1&+0&D3:5](-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)-Br>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:4](:[c&H0&+0&D3:5](-[C:6]):[s&H0&+0&D2:7]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([cH:6][cH:7]1)[C:8](=O)[CH:9](Br)[C:10](=[O:11])[O:12][CH2:13][CH3:14].[CH3:15][C:16]([NH2:17])=[S:18]>CCO>[CH3:14][CH2:13][O:12][C:10](=[O:11])[c:9]1[s:18][c:16]([n:17][c:8]1-[c:5]1[cH:6][cH:7][c:2]([cH:3][cH:4]1)[CH3:1])[CH3:15]|US20050288273A1_1287
4.1.59|[C:10]-[C&H0&+0&D3:9](-[C&H0&+0&D2:8]#[N&H0&+0&D1:7])=[C&H1&+0&D2:6]-O-C.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[c&H0&+0&D3:8](-[N&H2&+0&D1:7]):[n&H0&+0&D3:4](:[n&H0&+0&D2:5]:[c&H1&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|Cl.CO[CH:1]=[C:2]([C:3]#[N:4])[C:5]#[N:6].[CH3:7][O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1[NH:15][NH2:16]>[Na+].C[O-].CCO>[CH3:7][O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1-[n:15]1[n:16][cH:1][c:2]([c:5]1[NH2:6])[C:3]#[N:4]|US08232273B2_0391
4.1.59|[C:10]-[C&H0&+0&D3:9](-[C&H0&+0&D2:8]#[N&H0&+0&D1:7])=[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])-O-C.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:10]-[c&H0&+0&D3:9]1:[c&H0&+0&D3:8](-[N&H2&+0&D1:7]):[n&H1&+0&D2:2]:[n&H0&+0&D2:1]:[c&H0&+0&D3:6]:1-[c&H0&+0&D3:5](:[c:4]):[c:3]|CO[C:1](=[C:2]([C:3]#[N:4])[C:5]#[N:6])[c:7]1[cH:8][c:9]([cH:10][c:11]([cH:12]1)[F:13])[O:14][CH3:15].[NH2:16][NH2:17]>CCO>[CH3:15][O:14][c:9]1[cH:10][c:11]([cH:12][c:7]([cH:8]1)-[c:1]1[n:16][nH:17][c:5]([c:2]1[C:3]#[N:4])[NH2:6])[F:13]|US20200181150A1_0141
4.1.8|[C:11]-[C&H1&+0&D3:10](-[C&H0&+0&D3:9](-[C:8])=O)-[C&H0&+0&D3:7](-[C:6])=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:11]-[c&H0&+0&D3:10]1:[c&H0&+0&D3:9](-[C:8]):[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7]:1-[C:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=[O:3])[O:4][CH2:5][C:6](=O)[CH:7]1[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1=O.[NH2:13][NH:14][c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21]>Cl.CCN(CC)CC.CCO>[CH3:1][C:2](=[O:3])[O:4][CH2:5][c:6]1[c:7]2[CH2:8][CH2:9][CH2:10][CH2:11][c:12]2[n:13][n:14]1-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21]|US20080269193A1_0521
4.1.14|[C:11]-[N&H2&+0&D1:10].[C:9]-[C&H1&+0&D3:8](-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O)-[C&H0&+0&D3:2](-[C:1])=O>>[C:11]-[n&H0&+0&D3:10]1:[c&H0&+0&D3:6](:[c&H1&+0&D2:7]:[c&H0&+0&D3:8](-[C:9]):[c&H0&+0&D3:2]:1-[C:1])-[c&H0&+0&D3:5](:[c:4]):[c:3]|[ClH:1].[CH3:2][N:3]([CH3:4])[CH2:5][CH2:6][CH2:7][NH2:8].O=[C:9]([CH2:10][CH:11]1[CH2:12][S:13][CH2:14][CH2:15][C:16]1=O)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1>Cl.CCOCC.CCO>[ClH:1].[CH3:2][N:3]([CH3:4])[CH2:5][CH2:6][CH2:7][n:8]1[c:16]2[CH2:15][CH2:14][S:13][CH2:12][c:11]2[cH:10][c:9]1-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US03997557A
4.1.62|[C:10]-[C&H0&+0&D3:9](=[N&H1&+0&D1:8])-[N&H2&+0&D1:7].[C:6]-[C&H1&+0&D3:5](-[C&H0&+0&D3:4](=[O&H0&D1:3])-O-C)-[C&H0&+0&D3:2](-[C:1])=O>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:2](-[C:1]):[c&H0&+0&D3:5](-[C:6]):[c&H0&+0&D3:4](:[n&H1&+0&D2:7]:1)=[O&H0&D1:3]|CO[C:1](=[O:2])[CH:3]1[CH2:4][CH2:5][N:6]([CH2:7][C:8]1=O)[c:9]1[n:10][cH:11][cH:12][cH:13][c:14]1[Cl:15].[NH:16]=[C:17]([NH2:18])[CH2:19][CH2:20][N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1>>[O:2]=[c:1]1[nH:18][c:17]([n:16][c:8]2[CH2:7][N:6]([CH2:5][CH2:4][c:3]21)[c:9]1[n:10][cH:11][cH:12][cH:13][c:14]1[Cl:15])[CH2:19][CH2:20][N:21]1[CH2:22][CH2:23][O:24][CH2:25][CH2:26]1|EP2419417B1_0440
2.1.2|[O&H0&D1:11]=[C&H0&+0&D3:10](-[c:9]:[c:8]-[N&H1&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[O&H0&D1:11]=[c&H0&+0&D3:10]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:6](=[O&H0&D1:5]):[n&H1&+0&D2:7]:[c:8]:[c:9]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][N:2]([CH:3]=[O:4])[CH2:5][c:6]1[cH:7][cH:8][c:9]([c:10]([cH:11]1)[C:12](=[O:13])O)[NH:14][C:15](=[O:16])[NH:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[CH2:24][C@H:25]([NH:26][C:27](=[O:28])[c:29]1[c:30]([cH:31][cH:32][cH:33][c:34]1[Cl:35])[Cl:36])[C:37](=[O:38])[O:39][CH:40]([CH3:41])[CH3:42]>>[CH3:41][CH:40]([CH3:42])[O:39][C:37](=[O:38])[C@H:25]([CH2:24][c:21]1[cH:22][cH:23][c:18]([cH:19][cH:20]1)-[n:17]1[c:12]([c:10]2[cH:11][c:6]([cH:7][cH:8][c:9]2[nH:14][c:15]1=[O:16])[CH2:5][N:2]([CH3:1])[CH:3]=[O:4])=[O:13])[NH:26][C:27](=[O:28])[c:29]1[c:30]([cH:31][cH:32][cH:33][c:34]1[Cl:35])[Cl:36]|US20130053407A1_0427
4.1.59|[C:10]-[C&H0&+0&D3:9](-[C&H0&+0&D2:8]#[N&H0&+0&D1:7])=[C&H1&+0&D2:6]-O-C-C.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:10]-[c&H0&+0&D3:9]1:[c&H0&+0&D3:8](-[N&H2&+0&D1:7]):[n&H0&+0&D3:4](:[n&H0&+0&D2:5]:[c&H1&+0&D2:6]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|CCO[CH:1]=[C:2]([C:3]#[N:4])[C:5]#[N:6].[NH2:7][NH:8][c:9]1[cH:10][cH:11][c:12]([n:13][n:14]1)[Cl:15]>CCO>[N:4]#[C:3][c:2]1[cH:1][n:7][n:8]([c:5]1[NH2:6])-[c:9]1[cH:10][cH:11][c:12]([n:13][n:14]1)[Cl:15]|US20060167020A1_0081
4.1.48|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H0&+0&D3:7](-[C&H3&D1:6])=O)=O.[N&H2&+0&D1:5]-[c:4]:[n&H0&+0&D2:3]:[n&H1&+0&D2:2]:[c:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[c&H0&+0&D3:7](-[C&H3&D1:6]):[n&H0&+0&D2:5]:[c:4]:[n&H0&+0&D3:3]:1:[n&H0&+0&D2:2]:[c:1]|[CH3:1][C:2](=O)[CH2:3][C:4]([CH3:5])=O.[NH2:6][c:7]1[cH:8][cH:9][nH:10][n:11]1>CCOC(=O)c1c[nH]nc1N>[CH3:5][c:4]1[cH:3][c:2]([n:6][c:7]2[cH:8][cH:9][n:10][n:11]12)[CH3:1]|US20200339587A1_0301
4.2.48|[C:10]-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](-[C:7])=[O&H0&+0&D1:6].[O&H0&D1:5]=[C&H0&+0&D3:4](-[N&H0&+0&D2:3]=[C&H0&+0&D2:2]=[O&H0&D1:1])-Cl>>[C:10]-[c&H0&+0&D3:9]1:[c&H0&+0&D3:2](=[O&H0&D1:1]):[n&H1&+0&D2:3]:[c&H0&+0&D3:4](:[o&H0&+0&D2:6]:[c&H0&+0&D3:8]:1-[C:7])=[O&H0&D1:5]|[O:1]=[C:2]=[N:3][C:4](=[O:5])Cl.[O:6]=[C:7]1[CH2:8][CH2:9][CH2:10][CH:11]1[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1>CC(=O)OCC.O=C(O)O[Na]>[O:1]=[c:2]1[nH:3][c:4]([o:6][c:7]2[c:8]1[CH2:9][CH2:10][CH:11]2[c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)=[O:5]|US08486952B2_0752
1.3.8|[C&H3&D1:11]-[N&H1&+0&D2:10]-[C&H0&+0&D3:9](=[O&H0&D1:8])-[c:7]:[c&H0&+0&D3:6](:[c:5])-[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2](:[c:1])-F>>[C&H3&D1:11]-[n&H0&+0&D3:10]1:[c&H0&+0&D3:9](=[O&H0&D1:8]):[c:7]:[c&H0&+0&D3:6](:[c:5]):[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][NH:2][C:3](=[O:4])[c:5]1[cH:6][n:7][cH:8][cH:9][c:10]1-[c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1F)[Cl:17]>C1CCOC1.[NaH]>[CH3:1][n:2]1[c:3]([c:5]2[cH:6][n:7][cH:8][cH:9][c:10]2[c:11]2[cH:12][cH:13][c:14]([cH:15][c:16]21)[Cl:17])=[O:4]|US10174044B2_0278
4.1.61|[C:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H0&+0&D3:7](-[O&H0&+0&D2:6]-C)=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7](:[c&H1&+0&D2:8]:1)-[O&H1&+0&D1:6])-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][O:2][CH2:3][C:4](=O)[CH2:5][C:6](=O)[O:7]C.[N:8]#[C:9][c:10]1[cH:11][cH:12][n:13][c:14]([cH:15]1)[NH:16][NH2:17]>>[CH3:1][O:2][CH2:3][c:4]1[cH:5][c:6]([n:16]([n:17]1)-[c:14]1[cH:15][c:10]([cH:11][cH:12][n:13]1)[C:9]#[N:8])[OH:7]|EP2738172A1_0150
4.1.9|[C&H3&D1:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](=[O&H0&+0&D1:7])-[N&H1&+0&D2:6]-[c:5]:[c&H1&+0&D2:4]:[c:3])-[C&H0&+0&D3:2](-[O&H1&D1:1])=O>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[c&H0&+0&D3:8](-[O&H1&+0&D1:7]):[n&H0&+0&D2:6]:[c:5]:[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2]:1-[O&H1&D1:1]|[CH3:1][CH:2]([C:3](=O)[OH:4])[C:5](=[O:6])[NH:7][c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[F:14]>>[CH3:1][c:2]1[c:3]([c:9]2[cH:10][cH:11][cH:12][c:13]([c:8]2[n:7][c:5]1[OH:6])[F:14])[OH:4]|US08940724B2_0843
4.1.61|[C:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H0&+0&D3:7](-[O&H0&+0&D2:6]-C)=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7](:[c&H1&+0&D2:8]:1)-[O&H1&+0&D1:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|C[O:1][C:2](=O)[CH2:3][C:4](=O)[C:5]([F:6])([F:7])[F:8].[NH2:9][NH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17]>>[OH:1][c:2]1[cH:3][c:4]([n:9][n:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][c:16]1[Cl:17])[C:5]([F:6])([F:7])[F:8]|US06956053B2_0159
4.2.47|[O&H0&D1:11]=[C&H0&+0&D3:10](-Cl)-O-C.[O&H0&D1:9]=[C&H0&+0&D3:8](-[N&H1&+0&D2:7]-[c&H0&+0&D3:6](:[c:5]):[c:4])-[c:3]:[c:2]-[O&H1&+0&D1:1]>>[O&H0&D1:11]=[c&H0&+0&D3:10]1:[o&H0&+0&D2:1]:[c:2]:[c:3]:[c&H0&+0&D3:8](=[O&H0&D1:9]):[n&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|CO[C:1](=[O:2])Cl.[CH3:3][O:4][c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[OH:11])[C:12](=[O:13])[NH:14][c:15]1[cH:16][cH:17][c:18]([cH:19][c:20]1[F:21])[Cl:22]>Cl.c1ccncc1>[CH3:3][O:4][c:5]1[cH:6][cH:7][c:8]2[c:9]([cH:10]1)[o:11][c:1]([n:14]([c:12]2=[O:13])-[c:15]1[cH:16][cH:17][c:18]([cH:19][c:20]1[F:21])[Cl:22])=[O:2]|US08084620B2_0402
3.11.2|[C:12]-[C&H0&+0&D3:11](-[N&H0&+0&D3:10](-[c:9]:[c:8]-[C&H0&+0&D3:7](=[O&H0&D1:6])-[C&H2&+0&D2:5]-[C:4])-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:12]-[c&H0&+0&D3:11]1:[c&H0&+0&D3:5](-[C:4]):[c&H0&+0&D3:7](=[O&H0&D1:6]):[c:8]:[c:9]:[n&H0&+0&D3:10]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([OH:4])[CH2:5][NH:6][S:7](=[O:8])(=[O:9])[c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[CH2:16][CH2:17][C:18](=[O:19])[c:20]1[cH:21][cH:22][c:23]([cH:24][c:25]1[N:26]([C:27](=O)[C:28]([CH3:29])=[O:30])[c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)[Cl:37]>>[CH3:29][C:28](=[O:30])[c:27]1[c:17]([c:18]([c:20]2[cH:21][cH:22][c:23]([cH:24][c:25]2[n:26]1-[c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)[Cl:37])=[O:19])[CH2:16][c:13]1[cH:14][cH:15][c:10]([cH:11][cH:12]1)[S:7](=[O:8])(=[O:9])[NH:6][CH2:5][C:2]([CH3:1])([CH3:3])[OH:4]|US08163906B2_0377
4.1.48|[N&H1&+0&D1:10]=[C&H0&+0&D3:9](-[N&H2&+0&D1:8])-[N:7].[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:10]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D2:8]:[c&H0&+0&D3:9]:1-[N:7])-[c&H0&+0&D3:5](:[c:6]):[c:4]|[NH:1]=[C:2]([NH2:3])[NH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[C:11]([F:12])([F:13])[F:14].CN(C)[CH:15]=[CH:16][C:17](=O)[c:18]1[cH:19][n:20][cH:21][cH:22][cH:23]1.O=C(O)O>CCCO>[F:12][C:11]([F:13])([F:14])[c:9]1[cH:8][cH:7][cH:6][c:5]([cH:10]1)[NH:4][c:2]1[n:1][cH:15][cH:16][c:17]([n:3]1)-[c:18]1[cH:23][cH:22][cH:21][n:20][cH:19]1|US07799915B2_0167
4.1.48|[N&H1&+0&D1:10]=[C&H0&+0&D3:9](-[N&H2&+0&D1:8])-[N:7].[c:6]:[c&H0&+0&D3:5](:[s:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:10]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D2:8]:[c&H0&+0&D3:9]:1-[N:7])-[c&H0&+0&D3:5](:[c:6]):[s:4]|CN(C)[CH:1]=[CH:2][C:3](=O)[c:4]1[cH:5][cH:6][cH:7][s:8]1.[NH:9]=[C:10]([NH2:11])[NH:12][c:13]1[cH:14][cH:15][cH:16][c:17]([cH:18]1)[O:19][C:20]([F:21])([F:22])[CH:23]([F:24])[F:25].[O-][N+](=O)O>>[F:24][CH:23]([F:25])[C:20]([F:21])([F:22])[O:19][c:17]1[cH:16][cH:15][cH:14][c:13]([cH:18]1)[NH:12][c:10]1[n:9][cH:1][cH:2][c:3]([n:11]1)-[c:4]1[cH:5][cH:6][cH:7][s:8]1|US20090137572A1_0493
2.3.10|[O&H0&D1:10]=[C&H0&+0&D3:9](-[N&H1&+0&D2:8]-[N&H1&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-O-C)-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[O&H0&D1:10]=[c&H0&+0&D3:9]1:[n&H1&+0&D2:8]:[n&H1&+0&D2:7]:[c&H0&+0&D3:6](=[O&H0&D1:5]):[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|CO[C:1](=[O:2])[NH:3][NH:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>Cl.CCO.O[K]>[O:6]=[c:5]1[nH:4][nH:3][c:1]([n:7]1-[c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1)=[O:2]|EP3010889B1_0511
4.1.48|[N&H1&+0&D1:10]=[C&H0&+0&D3:9](-[N&H2&+0&D1:8])-[N:7].[c:6]:[c&H0&+0&D3:5](:[n:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:10]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D2:8]:[c&H0&+0&D3:9]:1-[N:7])-[c&H0&+0&D3:5](:[c:6]):[n:4]|Cl.Cl.CN(C)[CH:1]=[CH:2][C:3](=O)[c:4]1[cH:5][cH:6][cH:7][cH:8][n:9]1.[NH:10]=[C:11]([NH2:12])[NH:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)-[n:20]1[cH:21][cH:22][n:23][cH:24]1>CCCO.O[Na]>[cH:8]1[cH:7][cH:6][cH:5][c:4]([n:9]1)-[c:3]1[cH:2][cH:1][n:10][c:11]([n:12]1)[NH:13][c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)-[n:20]1[cH:21][cH:22][n:23][cH:24]1|US07253204B2_0347
4.1.8|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H0&+0&D3:7](-[C&H3&D1:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[c&H1&+0&D2:8]:[c&H0&+0&D3:7](-[C&H3&D1:6]):[n&H0&+0&D2:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=O)[CH2:3][C:4]([CH3:5])=O.[CH3:6][S:7](=[O:8])(=[O:9])[O:10][c:11]1[cH:12][c:13]([c:14]([cH:15][c:16]1[Cl:17])[F:18])[NH:19][NH2:20]>O.Cc1ccccc1.CCO>[CH3:1][c:2]1[cH:3][c:4]([n:20][n:19]1-[c:13]1[cH:12][c:11]([c:16]([cH:15][c:14]1[F:18])[Cl:17])[O:10][S:7]([CH3:6])(=[O:8])=[O:9])[CH3:5]|US20090093485A1_0813
4.1.48|[C:10]-[C&H0&+0&D3:9](-[C&H1&+0&D2:8]=[C&H1&+0&D2:7]-N(-C)-C)=O.[N&H1&+0&D1:6]=[C&H0&+0&D3:5](-[N&H2&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H1&+0&D2:7]:[c&H1&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|Cl.[CH3:1][O:2][CH:3]([O:4][CH3:5])[C:6](=O)[CH:7]=[CH:8]N(C)C.[NH:9]=[C:10]([NH2:11])[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[CH:18]([F:19])[F:20]>[Na+].CC[O-].CCO>[CH3:1][O:2][CH:3]([O:4][CH3:5])[c:6]1[cH:7][cH:8][n:9][c:10]([n:11]1)-[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[CH:18]([F:19])[F:20]|US20200239494A1_0755
9.7.261|[C&H3&D1:10]-[#14&H0&+0&D4:9](-[C&H3&D1:8])(-[C&H3&D1:7])-[C&H0&+0&D2:6]#[N&H0&D1:5].[C&H3&D1:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&D1:10]-[#14&H0&+0&D4:9](-[C&H3&D1:8])(-[C&H3&D1:7])-[O&H0&+0&D2:1]-[C&H0&+0&D4:3](-[C&H3&D1:4])(-[C:2])-[C&H0&+0&D2:6]#[N&H0&D1:5]|[CH3:1][C:2](=[O:3])[C:4]12[CH2:5][CH:6]3[CH2:7][CH:8]([CH2:9][CH:10]([CH2:11]3)[CH2:12]1)[CH2:13]2.[CH3:14][Si:15]([CH3:16])([CH3:17])[C:18]#[N:19]>ClCCl.I[Zn]I>[CH3:14][Si:15]([CH3:16])([CH3:17])[O:3][C:2]([CH3:1])([C:18]#[N:19])[C:4]12[CH2:5][CH:6]3[CH2:7][CH:8]([CH2:9][CH:10]([CH2:11]3)[CH2:12]1)[CH2:13]2|US20130345432A1_0074
4.1.59|[C&H3&D1:10]-[N&H1&+0&D2:9]-[N&H2&+0&D1:8].[N&H0&+0&D1:7]#[C&H0&+0&D2:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C&H3&D1:10]-[n&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:4](:[c&H1&+0&D2:5]:[c&H0&+0&D3:6]:1-[N&H2&+0&D1:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][NH:2][NH2:3].[N:4]#[C:5][CH2:6][C:7](=O)[c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>CC(C)O>[CH3:1][n:2]1[n:3][c:7]([cH:6][c:5]1[NH2:4])-[c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1|US08785468B2_0376
4.1.4|[C&H1&+0&D1:11]#[C&H0&+0&D2:10]-[c&H0&+0&D3:9](:[n:8]):[n:7].[N&H0&-&D1:6]=[N&H0&+&D2:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[c&H1&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:6]:[n&H0&+0&D2:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:9](:[n:8]):[n:7]|[CH:1]#[C:2][c:3]1[n:4][c:5]2[c:6]([nH:7]1)[c:8]([n:9]([c:10]([n:11]2[CH3:12])=[O:13])[CH3:14])=[O:15].[CH3:16][O:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1[N:24]=[N+:25]=[N-:26]>>[CH3:16][O:17][c:18]1[cH:19][cH:20][cH:21][cH:22][c:23]1-[n:24]1[cH:1][c:2]([n:26][n:25]1)-[c:3]1[n:4][c:5]2[c:6]([nH:7]1)[c:8]([n:9]([c:10]([n:11]2[CH3:12])=[O:13])[CH3:14])=[O:15]|EP2465859A1_0175
4.1.27|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C&H3&D1:7])-[C&H0&+0&D3:6](=[O&H0&+0&D1:5])-O-C)=O.[N&H2&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:6](-[O&H1&+0&D1:5]):[c&H0&+0&D3:8]:1-[C&H3&D1:7]|[CH3:1][c:2]1[cH:3][c:4]([cH:5][cH:6][c:7]1[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[O:15][C:16]([F:17])([F:18])[F:19])[NH2:20].CO[C:21](=[O:22])[CH:23]([CH3:24])[C:25]([CH3:26])=O>Cc1c(nc2ccc(c(c2c1O)C)Oc1ccc(cc1)OC(F)(F)F)C.Cc1ccc(cc1)S(=O)(=O)O.Cc1ccccc1C>[CH3:26][c:25]1[n:20][c:4]2[cH:3][c:2]([c:7]([cH:6][c:5]2[c:21]([c:23]1[CH3:24])[OH:22])[O:8][c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[O:15][C:16]([F:17])([F:18])[F:19])[CH3:1]|US08765940B2_0467
4.1.14|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[C&H3&D1:5])=O)=O.[N&H2&+0&D1:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:6](-[C&H3&D1:5]):[c&H1&+0&D2:7]:[c&H1&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=O)[CH2:3][CH2:4][C:5]([CH3:6])=O.[NH2:7][c:8]1[cH:9][c:10]([cH:11][c:12]([c:13]1[O:14][c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[S:21]([NH2:22])(=[O:23])=[O:24])[C:25](=[O:26])[OH:27]>CC(=O)O>[CH3:6][c:5]1[cH:4][cH:3][c:2]([n:7]1-[c:8]1[cH:9][c:10]([cH:11][c:12]([c:13]1[O:14][c:15]1[cH:20][cH:19][cH:18][cH:17][cH:16]1)[S:21]([NH2:22])(=[O:23])=[O:24])[C:25](=[O:26])[OH:27])[CH3:1]|EP3498694A1_0133
4.1.8|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H0&+0&D3:7](-[C&H3&D1:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[n:2]):[n:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7](-[C&H3&D1:6]):[c&H1&+0&D2:8]:1)-[c&H0&+0&D3:3](:[n:2]):[n:1]|[CH3:1][C:2](=O)[CH2:3][C:4]([CH3:5])=O.[NH2:6][NH:7][c:8]1[n:9][c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]2[n+:16]([n:17]1)[O-:18])[Cl:19]>CCO>[CH3:1][c:2]1[cH:3][c:4]([n:6][n:7]1-[c:8]1[n:9][c:10]2[cH:11][cH:12][c:13]([cH:14][c:15]2[n+:16]([n:17]1)[O-:18])[Cl:19])[CH3:5]|US20110237607A1_0122
4.1.4|[C&H1&+0&D1:11]#[C&H0&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[c:7].[N&H0&-&D1:6]=[N&H0&+&D2:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:3](:[n:2]):[n:1]>>[c&H1&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:6]:[n&H0&+0&D2:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[n:2]):[n:1])-[c&H0&+0&D3:9](:[c:8]):[c:7]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)/[C:9](=[C:10](/[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[N-:29]=[N+:30]=[N:31][c:32]1[n:33][c:34]([n:35][c:36]([n:37]1)[Cl:38])[Cl:39]>>[Cl:39][c:34]1[n:35][c:36]([n:37][c:32]([n:33]1)-[n:31]1[cH:1][c:2]([n:29][n:30]1)-[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)/[C:9](=[C:10](/[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)[Cl:38]|EP2465859A1_0238
4.1.4|[C&H1&+0&D1:11]#[C&H0&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[c:7].[N&H0&-&D1:6]=[N&H0&+&D2:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[c&H1&+0&D2:11]1:[n&H0&+0&D2:6]:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:10]:1-[c&H0&+0&D3:9](:[c:8]):[c:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[N:9]([CH3:10])[CH3:11].[CH3:12][O:13][c:14]1[cH:15][c:16]([cH:17][c:18]([c:19]1[O:20][CH3:21])[O:22][CH3:23])[N:24]=[N+:25]=[N-:26]>>[CH3:21][O:20][c:19]1[c:14]([cH:15][c:16]([cH:17][c:18]1[O:22][CH3:23])-[n:24]1[n:25][n:26][cH:1][c:2]1-[c:3]1[cH:8][cH:7][c:6]([cH:5][cH:4]1)[N:9]([CH3:10])[CH3:11])[O:13][CH3:12]|US20120035217A1_0180
4.1.14|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H2&+0&D2:7]-[C&H0&+0&D3:6](-[C&H3&D1:5])=O)=O.[N&H2&+0&D1:4]-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:6](-[C&H3&D1:5]):[c&H1&+0&D2:7]:[c&H1&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:2]):[n:1]|[N:1]#[C:2][c:3]1[n:4][n:5]([c:6]([c:7]1[S:8][C:9]([F:10])([F:11])[F:12])[NH2:13])-[c:14]1[c:15]([cH:16][c:17]([cH:18][c:19]1[Cl:20])[C:21]([F:22])([F:23])[F:24])[Cl:25].[CH3:26][C:27](=O)[CH2:28][CH2:29][C:30]([CH3:31])=O>Cc1ccc(cc1)S(=O)(=O)O.Cc1ccccc1.ClCCl>[CH3:26][c:27]1[cH:28][cH:29][c:30]([n:13]1-[c:6]1[c:7]([c:3]([n:4][n:5]1-[c:14]1[c:15]([cH:16][c:17]([cH:18][c:19]1[Cl:20])[C:21]([F:22])([F:23])[F:24])[Cl:25])[C:2]#[N:1])[S:8][C:9]([F:10])([F:11])[F:12])[CH3:31]|US20180282282A1_2551
4.1.4|[C&H1&+0&D1:11]#[C&H0&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[n:7].[N&H0&-&D1:6]=[N&H0&+&D2:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[c&H1&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:6]:[n&H0&+0&D2:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:9](:[c:8]):[n:7]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][cH:6][cH:7][n:8]1.[CH3:9][c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1[N:16]=[N+:17]=[N-:18])[C:19](=[O:20])[OH:21]>Cc1ccc(cc1-n1cc(nn1)-c1ccc(nc1)Cl)C(=O)O>[CH3:9][c:10]1[cH:11][cH:12][c:13]([cH:14][c:15]1-[n:16]1[cH:1][c:2]([n:18][n:17]1)-[c:3]1[cH:4][cH:5][cH:6][cH:7][n:8]1)[C:19](=[O:20])[OH:21]|US20180213779A1_0524
4.1.4|[C&H1&+0&D1:11]#[C&H0&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[c:7].[N&H0&-&D1:6]=[N&H0&+&D2:5]=[N&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[c&H1&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:6]:[n&H0&+0&D2:5]:[n&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:9](:[c:8]):[c:7]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]2[CH2:7][C@@H:8]3[CH2:9][CH2:10][C@H:11]([CH2:12][c:13]2[cH:14]1)[C@@:15]31[CH2:16][N:17]([S:18]([NH:19]1)(=[O:20])=[O:21])[CH2:22][C:23]([F:24])([F:25])[F:26].[N-:27]=[N+:28]=[N:29][c:30]1[cH:31][cH:32][c:33]([cH:34][cH:35]1)[F:36]>Cc1ccc(cc1)C>[O:20]=[S:18]1([NH:19][C@@:15]2([CH2:16][N:17]1[CH2:22][C:23]([F:24])([F:25])[F:26])[C@@H:11]1[CH2:10][CH2:9][C@H:8]2[CH2:7][c:6]2[cH:5][cH:4][c:3]([cH:14][c:13]2[CH2:12]1)-[c:2]1[cH:1][n:29]([n:28][n:27]1)-[c:30]1[cH:35][cH:34][c:33]([cH:32][cH:31]1)[F:36])=[O:21]|US20200308163A1_0505
4.3.3|[C&H3&D1:10]-[C&H1&+0&D3:9](-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)-Br.[N&H2&+0&D1:4]-[C&H0&+0&D3:3](-[N&H2&D1:2])=[S&H0&+0&D1:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[s&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5])-[N&H2&D1:2]|[CH3:1][CH:2](Br)[C:3](=O)[c:4]1[cH:5][nH:6][c:7]2[n:8][cH:9][cH:10][cH:11][c:12]21.[NH2:13][C:14]([NH2:15])=[S:16]>CCO>[CH3:1][c:2]1[s:16][c:14]([n:15][c:3]1-[c:4]1[cH:5][nH:6][c:7]2[n:8][cH:9][cH:10][cH:11][c:12]21)[NH2:13]|US20160046616A1_0471
4.2.4|[C&H1&+0&D1:11]#[C&H0&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[c:7].[O&H1&+0&D1:6]-[N&H0&+0&D2:5]=[C&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[c&H1&+0&D2:11]1:[c&H0&+0&D3:10](:[o&H0&+0&D2:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:9](:[c:8]):[c:7]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]#[N:10].[CH3:11][O:12][c:13]1[cH:14][c:15]2[c:16]([cH:17][c:18]1[CH:19]=[N:20][OH:21])[C:22]([CH2:23][CH2:24][C:25]2([CH3:26])[CH3:27])([CH3:28])[CH3:29]>ClO[Na]>[CH3:28][C:22]1([CH2:23][CH2:24][C:25]([c:15]2[cH:14][c:13]([c:18]([cH:17][c:16]21)-[c:19]1[cH:1][c:2]([o:21][n:20]1)-[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9]#[N:10])[O:12][CH3:11])([CH3:26])[CH3:27])[CH3:29]|EP1503998B1_0214
4.1.59|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H1&+0&D3:8](-[C&H0&+0&D2:7]#[N&H0&+0&D1:6])-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:1]:[n&H1&+0&D2:2]:[c&H0&+0&D3:7](-[N&H2&+0&D1:6]):[c&H0&+0&D3:8]:1-[c&H0&+0&D3:5](:[c:4]):[c:3]|O.[CH3:1][C:2](=O)[CH:3]([C:4]#[N:5])[c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1[CH3:12])[CH3:13].[NH2:14][NH2:15]>CC(=O)O.Cc1ccccc1>[CH3:1][c:2]1[n:14][nH:15][c:4]([c:3]1-[c:6]1[cH:7][cH:8][c:9]([cH:10][c:11]1[CH3:12])[CH3:13])[NH2:5]|US10604525B2_0637
4.1.59|[C&H3&D1:10]-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[C&H0&+0&D2:7]#[N&H0&+0&D1:6])=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7](-[N&H2&+0&D1:6]):[c&H1&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=O)[CH2:3][C:4]#[N:5].[NH2:6][NH:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1>CCO>[CH3:1][c:2]1[cH:3][c:4]([n:7]([n:6]1)-[c:8]1[cH:13][cH:12][cH:11][cH:10][cH:9]1)[NH2:5]|US20070191336A1_1257
4.1.62|[C&H3&D1:10]-[C&H0&+0&D3:9](=[N&H1&+0&D1:8])-[N&H2&+0&D1:7].[C:6]-[C&H1&+0&D3:5](-[C&H0&+0&D3:4](=[O&H0&D1:3])-O-C)-[C&H0&+0&D3:2](-[C:1])=O>>[C&H3&D1:10]-[c&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:2](-[C:1]):[c&H0&+0&D3:5](-[C:6]):[c&H0&+0&D3:4](:[n&H1&+0&D2:7]:1)=[O&H0&D1:3]|Cl.[CH3:1][O:2][CH2:3][C:4](=O)[CH:5]([CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[C:19]#[N:20])[C:21](=[O:22])OC.[CH3:23][C:24](=[NH:25])[NH2:26]>[Na+].C[O-].CO.C1COCCO1>[CH3:1][O:2][CH2:3][c:4]1[n:25][c:24]([nH:26][c:21]([c:5]1[CH2:6][c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[C:19]#[N:20])=[O:22])[CH3:23]|US20100190687A1_0869
3.10.3|[c:12]:[c&H0&+0&D3:11](:[c&H1&+0&D2:10]:[c:9])-[c&H0&+0&D3:8](:[c:7]):[c&H0&+0&D3:6](:[c:5])-[c&H0&+0&D3:4](:[c:3]):[c&H1&+0&D2:2]:[c:1]>>[c:12]:[c&H0&+0&D3:11]1:[c&H0&+0&D3:10](:[c:9]):[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:6](:[c:5]):[c&H0&+0&D3:8]:1:[c:7]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)-[c:9]1[cH:10][cH:11][cH:12][cH:13][c:14]1-[c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[O:21][CH3:22]>CO.ClCCl.Cl[Fe](Cl)Cl>[CH3:22][O:21][c:19]1[cH:18][cH:17][c:16]2[c:15]([cH:20]1)[c:14]1[cH:13][cH:12][cH:11][cH:10][c:9]1[c:7]1[cH:8][c:3]([cH:4][cH:5][c:6]12)[O:2][CH3:1]|US20160204352A1_0104
4.2.37|[O&H0&D1:11]=[C&H0&+0&D3:10](-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)-O-C.[O&H1&+0&D1:4]-[c:3]:[c&H1&+0&D2:2]:[c:1]>>[O&H0&D1:11]=[c&H0&+0&D3:10]1:[o&H0&+0&D2:4]:[c:3]:[c&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:8](:[c&H1&+0&D2:9]:1)-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[OH:9].CO[C:10](=[O:11])[CH2:12][C:13](=O)[c:14]1[cH:15][cH:16][cH:17][c:18]([cH:19]1)[O:20][CH2:21][CH2:22][CH3:23]>O.CCOC(C)=O.O=S(=O)(O)O.ClCCCl>[CH3:23][CH2:22][CH2:21][O:20][c:18]1[cH:17][cH:16][cH:15][c:14]([cH:19]1)-[c:13]1[cH:12][c:10]([o:9][c:7]2[cH:8][c:3]([cH:4][cH:5][c:6]12)[O:2][CH3:1])=[O:11]|US20080188521A1_0154
4.1.29|[N&H2&+0&D1:12]-[c:11]:[c:10]-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[c:6])=O.[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H2&+0&D2:2]-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:12]1:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](:[c&H0&+0&D3:9](:[c:10]:[c:11]:1)-[c&H0&+0&D3:8](:[c:7]):[c:6])-[c&H0&+0&D3:4](:[c:5]):[c:3]|[NH2:1][c:2]1[c:3]([cH:4][cH:5][cH:6][c:7]1[C:8](=O)[c:9]1[cH:10][c:11]([cH:12][cH:13][cH:14]1)[OH:15])[C:16]([F:17])([F:18])[F:19].O=[CH:20][CH2:21][c:22]1[cH:23][cH:24][cH:25][cH:26][c:27]1[F:28]>>[OH:15][c:11]1[cH:12][cH:13][cH:14][c:9]([cH:10]1)-[c:8]1[c:21]([cH:20][n:1][c:2]2[c:3]([cH:4][cH:5][cH:6][c:7]12)[C:16]([F:17])([F:18])[F:19])-[c:22]1[cH:23][cH:24][cH:25][cH:26][c:27]1[F:28]|US07576215B2_0814
4.1.53|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-[N&H2&+0&D1:8])-[c&H0&+0&D3:7](:[n:6]):[n:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:8]:[n&H0&+0&D2:9]:[c&H0&+0&D3:10]:1-[c&H0&+0&D3:7](:[n:6]):[n:5])-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)[CH:8]=O)[OH:9].[NH:10]=[C:11]([NH:12][NH2:13])[c:14]1[n:15][cH:16][cH:17][cH:18][n:19]1>>[CH3:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)-[c:8]1[n:10][c:11]([n:12][nH:13]1)-[c:14]1[n:19][cH:18][cH:17][cH:16][n:15]1)[OH:9]|US20050075375A1_1429
4.1.53|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-[N&H2&+0&D1:8])-[c&H0&+0&D3:7](:[c:6]):[c:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:8]:[n&H0&+0&D2:9]:[c&H0&+0&D3:10]:1-[c&H0&+0&D3:7](:[c:6]):[c:5])-[c&H0&+0&D3:3](:[c:4]):[c:2]|[NH:1]=[C:2]([NH:3][NH2:4])[c:5]1[cH:6][n:7][cH:8][cH:9][c:10]1[C:11]([F:12])([F:13])[F:14].[CH3:15][CH:16]([CH3:17])[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[CH:24]=O>>[CH3:15][CH:16]([CH3:17])[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)-[c:24]1[n:1][c:2]([n:3][nH:4]1)-[c:5]1[cH:6][n:7][cH:8][cH:9][c:10]1[C:11]([F:12])([F:13])[F:14]|US20050075375A1_1287
4.1.53|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-[N&H2&+0&D1:8])-[c&H0&+0&D3:7](:[c:6]):[n:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:1](:[n&H1&+0&D2:8]:[n&H0&+0&D2:9]:[c&H0&+0&D3:10]:1-[c&H0&+0&D3:7](:[c:6]):[n:5])-[c&H0&+0&D3:3](:[c:4]):[c:2]|[NH:1]=[C:2]([NH:3][NH2:4])[c:5]1[cH:6][cH:7][cH:8][cH:9][n:10]1.O=[CH:11][c:12]1[cH:13][cH:14][cH:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21>[Na+].CC(=O)N(C)C.[O-]S(=O)O>[cH:7]1[cH:8][cH:9][n:10][c:5]([cH:6]1)-[c:2]1[n:1][c:11]([nH:4][n:3]1)-[c:12]1[cH:13][cH:14][cH:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21|US20050075375A1_1574
4.1.29|[C&H3&+0&D1:12]-[C&H0&+0&D3:11](-[c&H0&+0&D3:10](:[c:9]):[c:8])=O.[N&H2&+0&D1:7]-[c:6]:[c:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[c&H1&+0&D2:12]1:[c&H0&+0&D3:11](:[n&H0&+0&D2:7]:[c:6]:[c:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:10](:[c:9]):[c:8]|[CH3:1][C:2](=O)[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[F:9].[NH2:10][c:11]1[cH:12][cH:13][c:14]([cH:15][c:16]1[C:17](=O)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[Cl:24]>>[F:9][c:6]1[cH:7][cH:8][c:3]([cH:4][cH:5]1)-[c:2]1[cH:1][c:17]([c:16]2[cH:15][c:14]([cH:13][cH:12][c:11]2[n:10]1)[Cl:24])-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20140191205A1_0043
4.1.49|[C:11]-[C&H0&+0&D3:10](-[C&H0&+0&D2:9]#[N&H0&+0&D1:8])=[C&H0&+0&D3:7](-[N&H2&+0&D1:6])-[N:5].[C:4]-[C&H0&+0&D3:3](-[C&H2&+0&D2:2]-[C:1])=O>>[C:11]-[c&H0&+0&D3:10]1:[c&H0&+0&D3:9](-[N&H2&+0&D1:8]):[c&H0&+0&D3:2](-[C:1]):[c&H0&+0&D3:3](-[C:4]):[n&H0&+0&D2:6]:[c&H0&+0&D3:7]:1-[N:5]|[CH3:1][N:2]([CH3:3])[CH2:4][CH2:5][O:6][C:7](=[O:8])[C:9]1=[C:10]([NH:11][C:12](=[C:13]([CH:14]1[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[C:21]#[N:22])[NH2:23])[CH3:24].O=[C:25]1[CH2:26][CH2:27][C:28]([CH2:29][CH2:30]1)([F:31])[F:32]>>[CH3:24][C:10]1[NH:11][c:12]2[n:23][c:25]3[CH2:30][CH2:29][C:28]([CH2:27][c:26]3[c:21]([c:13]2[CH:14]([C:9]=1[C:7](=[O:8])[O:6][CH2:5][CH2:4][N:2]([CH3:1])[CH3:3])[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)[NH2:22])([F:31])[F:32]|
4.1.58|[N&H2&+0&D1:12]-[c:11]:[c:10]-[N&H2&+0&D1:9].[c:8]:[c&H0&+0&D3:7]1:[c:6]-[C&H0&+0&D3:5](-[C&H0&+0&D3:4](-[c:3]:[c&H0&+0&D3:2]-1:[c:1])=O)=O>>[n&H0&+0&D2:12]1:[c:11]:[c:10]:[n&H0&+0&D2:9]:[c&H0&+0&D3:5]2:[c:6]:[c&H0&+0&D3:7](:[c:8]):[c&H0&+0&D3:2](:[c:1]):[c:3]:[c&H0&+0&D3:4]:1:2|[NH2:1][c:2]1[cH:3][cH:4][c:5]([cH:6][c:7]1[NH2:8])[Cl:9].O=[C:10]1[C:11]([c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2-[c:18]2[cH:19][cH:20][cH:21][cH:22][c:23]12)=O>>[Cl:9][c:5]1[cH:4][cH:3][c:2]2[n:1][c:10]3[c:23]4[cH:22][cH:21][cH:20][cH:19][c:18]4[c:17]4[cH:16][cH:15][cH:14][cH:13][c:12]4[c:11]3[n:8][c:7]2[cH:6]1|US07803898B2_0239
4.1.58|[N&H2&+0&D1:12]-[c:11]:[c:10]-[N&H2&+0&D1:9].[c:8]:[c&H0&+0&D3:7](:[c:6])-[C&H0&+0&D3:5](-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)=O>>[n&H0&+0&D2:12]1:[c:11]:[c:10]:[n&H0&+0&D2:9]:[c&H0&+0&D3:4](:[c&H0&+0&D3:5]:1-[c&H0&+0&D3:7](:[c:8]):[c:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][c:2]1[c:3]([cH:4][cH:5][c:6]([c:7]1[NH2:8])[Br:9])[Br:10].O=[C:11]([C:12](=O)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>CC(=O)O.CC(C)O.O=C(O)C(F)(F)F.Brc1ccc(c2nsnc12)Br.[Zn]>[Br:10][c:3]1[cH:4][cH:5][c:6]([c:7]2[n:8][c:12]([c:11]([n:1][c:2]12)-[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[Br:9]|US20200079787A1_0255
4.1.58|[N&H2&+0&D1:12]-[c:11]:[c:10]-[N&H2&+0&D1:9].[c:8]:[c&H0&+0&D3:7](:[c:6])-[C&H0&+0&D3:5](-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)=O>>[n&H0&+0&D2:12]1:[c:11]:[c:10]:[n&H0&+0&D2:9]:[c&H0&+0&D3:5](:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:7](:[c:8]):[c:6]|[NH2:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[NH2:8].O=[C:9]([C:10](=O)[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[OH:17])[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[OH:24]>CCO>[OH:17][c:14]1[cH:15][cH:16][c:11]([cH:12][cH:13]1)-[c:10]1[n:8][c:7]2[cH:6][cH:5][cH:4][cH:3][c:2]2[n:1][c:9]1-[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[OH:24]|US20200147078A1_0130
4.1.34|[c:12]:[c&H0&+0&D3:11](:[c:10])-[C&H0&+0&D3:9](-[C&H2&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[c:4]:[c&H1&+0&D2:3]:[c:2]-[N&H1&+0&D2:1]-N>>[c:12]:[c&H0&+0&D3:11](:[c:10])-[c&H0&+0&D3:9]1:[c&H0&+0&D3:8](:[c&H0&+0&D3:3](:[c:4]):[c:2]:[n&H1&+0&D2:1]:1)-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH2:11][C:12](=O)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[F:19].N[NH:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>CC(=O)O.Cc1ccccc1.CS(=O)(=O)O.CCOC(C)=O>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[c:26]2[cH:25][cH:24][cH:23][cH:22][c:21]2[nH:20][c:12]1-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[F:19]|US20050261331A1_0232
4.1.59|[C:11]-[C&H1&+0&D3:10](-[C&H0&+0&D2:9]#[N&H0&+0&D1:8])-[C&H0&+0&D3:7](-[C:6])=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:11]-[c&H0&+0&D3:10]1:[c&H0&+0&D3:9](-[N&H2&+0&D1:8]):[n&H0&+0&D3:4](:[n&H0&+0&D2:5]:[c&H0&+0&D3:7]:1-[C:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[N:1]#[C:2][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][C:8]1=O.[NH2:9][NH:10][c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]>CCN(CC)CC.Cc1ccccc1.CC(=O)O.N#C[K].O=C1CCCCC1Cl>[NH2:1][c:2]1[c:3]2[CH2:4][CH2:5][CH2:6][CH2:7][c:8]2[n:9][n:10]1-[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[Cl:17]|US20070259920A1_0090
4.1.61|[C&H3&D1:10]-[N&H1&+0&D2:9]-[N&H2&+0&D1:8].[c:7]:[c&H0&+0&D3:6](:[c:5])-[C&H0&+0&D3:4](-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[O&H0&+0&D2:1]-C)=O)=O>>[C&H3&D1:10]-[n&H0&+0&D3:9]1:[n&H0&+0&D2:8]:[c&H0&+0&D3:4](:[c&H1&+0&D2:3]:[c&H0&+0&D3:2]:1-[O&H1&+0&D1:1])-[c&H0&+0&D3:6](:[c:7]):[c:5]|C[O:1][C:2](=O)[CH2:3][C:4](=O)[c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[Cl:12].O=S(=O)(O)O.[CH3:13][NH:14][NH2:15]>CCN(CC)CC.CCCCCC.CCO>[CH3:13][n:14]1[n:15][c:4]([cH:3][c:2]1[OH:1])-[c:5]1[cH:6][cH:7][c:8]([cH:9][c:10]1[Cl:11])[Cl:12]|EP2900655B1_1382
4.2.4|[C&H1&+0&D1:11]#[C&H0&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[c:7].[O&H1&+0&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Cl>>[c&H1&+0&D2:11]1:[c&H0&+0&D3:10](:[o&H0&+0&D2:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:9](:[c:8]):[c:7]|[CH:1]#[C:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[CH3:15][O:16][C:17](=[O:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[C:25](Cl)=[N:26][OH:27]>CCN(CC)CC.C1CCOC1.ClCCl>[CH3:15][O:16][C:17](=[O:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)-[c:25]1[cH:1][c:2]([o:27][n:26]1)-[c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]|US09079930B2_0664
4.2.4|[C&H1&+0&D1:11]#[C&H0&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[n:7].[O&H1&+0&D1:6]-[N&H0&+0&D2:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Cl>>[c&H1&+0&D2:11]1:[c&H0&+0&D3:10](:[o&H0&+0&D2:6]:[n&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:9](:[c:8]):[n:7]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)[C:16](Cl)=[N:17][OH:18])[CH:19]1[CH2:20][CH2:21][O:22][CH2:23][CH2:24]1.[CH:25]#[C:26][c:27]1[n:28][c:29]([cH:30][n:31][c:32]1[N:33]([C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[C:41](=[O:42])[O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[Br:48]>CCN(CC)CC.ClCCl.O>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([CH2:9][c:10]1[cH:11][cH:12][c:13]([cH:14][cH:15]1)-[c:16]1[cH:25][c:26]([o:18][n:17]1)-[c:27]1[n:28][c:29]([cH:30][n:31][c:32]1[N:33]([C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[C:41](=[O:42])[O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[Br:48])[CH:19]1[CH2:20][CH2:21][O:22][CH2:23][CH2:24]1|US08765751B2_0244
4.1.59|[C:11]-[C&H0&+0&D3:10](=[C&H0&+0&D3:9](-[C:8])-[C&H0&+0&D2:7]#[N&H0&+0&D1:6])-O-C.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7](-[N&H2&+0&D1:6]):[c&H0&+0&D3:9]:1-[C:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][NH:2][c:3]1[c:4]([cH:5][c:6]([cH:7][c:8]1[Cl:9])[C:10]([F:11])([F:12])[F:13])[Cl:14].CO[C:15](=[C:16]([C:17]#[N:18])[C:19]#[N:20])[CH:21]1[CH2:22][CH2:23]1>CO.[NaH]>[N:18]#[C:17][c:16]1[c:15]([n:1][n:2]([c:19]1[NH2:20])-[c:3]1[c:4]([cH:5][c:6]([cH:7][c:8]1[Cl:9])[C:10]([F:11])([F:12])[F:13])[Cl:14])[CH:21]1[CH2:22][CH2:23]1|US20090054413A1_0206
4.2.16|[O&H0&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-[C&H2&+0&D2:8]-[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[c:4])=O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[o&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[c&H1&+0&D2:8]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]|O=[C:1]([CH2:2][NH:3][C:4](=[O:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[C:12](=[O:13])[OH:14])[c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[C:21]([F:22])([F:23])[F:24]>O=S(=O)(O)O.O.O>[O:13]=[C:12]([OH:14])[c:11]1[cH:10][cH:9][cH:8][cH:7][c:6]1-[c:4]1[n:3][cH:2][c:1]([o:5]1)-[c:15]1[cH:16][cH:17][cH:18][c:19]([cH:20]1)[C:21]([F:22])([F:23])[F:24]|US07179822B2_0877
4.2.3|[O&H0&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[c:4])=O)-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[o&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[n&H0&+0&D2:8]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4])-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)[C:8](=O)[NH:9][NH:10][C:11](=[O:12])[c:13]1[n:14][c:15]2[cH:16][cH:17][c:18]([cH:19][n:20]2[c:21]([c:22]1[O:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)=[O:31])[CH3:32]>>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([cH:7]1)-[c:8]1[n:9][n:10][c:11]([o:12]1)-[c:13]1[n:14][c:15]2[cH:16][cH:17][c:18]([cH:19][n:20]2[c:21]([c:22]1[O:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)=[O:31])[CH3:32]|US10118930B2_1949
4.2.3|[O&H0&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[n:4])=O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[o&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[n&H0&+0&D2:8]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[n:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[C:9](=[O:10])[NH:11][NH:12][C:13](=O)[c:14]1[cH:15][c:16]([n:17][n:18]1-[c:19]1[cH:20][s:21][c:22]([cH:23]1)[CH2:24][NH:25][C:26](=[O:27])[C@H:28]([CH3:29])[NH:30][C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[C:38]([F:39])([F:40])[F:41]>CC(C)N=C=NC(C)C.CN(C)C=O>[CH3:35][C:34]([CH3:36])([CH3:37])[O:33][C:31](=[O:32])[NH:30][C@@H:28]([CH3:29])[C:26](=[O:27])[NH:25][CH2:24][c:22]1[cH:23][c:19]([cH:20][s:21]1)-[n:18]1[n:17][c:16]([cH:15][c:14]1-[c:13]1[n:12][n:11][c:9]([o:10]1)-[c:8]1[cH:7][cH:6][cH:5][cH:4][c:3]1[O:2][CH3:1])[C:38]([F:39])([F:40])[F:41]|US20200390776A1_0396
4.2.3|[O&H0&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-[N&H1&+0&D2:8]-[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[c:4])=O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[o&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[n&H0&+0&D2:8]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[O:9])[NH:10][NH:11][C:12](=O)[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[Cl:19]>O.O.O>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:10][n:11][c:12]([o:9]1)-[c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[Cl:19]|US10118930B2_3879
4.1.59|[C:11]-[N&H1&+0&D2:10]-[N&H2&+0&D1:9].[C:8]-[C&H0&+0&D3:7](-[C&H0&+0&D2:6]#[N&H0&+0&D1:5])=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O-C>>[C:11]-[n&H0&+0&D3:10]1:[n&H0&+0&D2:9]:[c&H0&+0&D3:4](:[c&H0&+0&D3:7](-[C:8]):[c&H0&+0&D3:6]:1-[N&H2&+0&D1:5])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[O:10][CH3:11])[C:12](OC)=[C:13]([C:14]#[N:15])[C:16]#[N:17].[CH3:18][CH:19]([CH3:20])[NH:21][NH2:22].Cl>CCN(CC)CC.CCO.O>[CH3:1][CH2:2][O:3][c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[O:10][CH3:11])-[c:12]1[n:22][n:21]([c:16]([c:13]1[C:14]#[N:15])[NH2:17])[CH:19]([CH3:18])[CH3:20]|US20190152952A1_0151
4.2.2|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[N&H0&+0&D2:9]-[O&H0&+0&D2:8]-[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[c:4])=O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:8]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][C:2](=[N:3][O:4][C:5](=O)[c:6]1[cH:7][n:8][c:9]([c:10]([cH:11]1)[Cl:12])[Cl:13])[c:14]1[cH:15][cH:16][cH:17][c:18]2[nH:19][cH:20][cH:21][c:22]21>C1COCCO1>[Cl:13][c:9]1[n:8][cH:7][c:6]([cH:11][c:10]1[Cl:12])-[c:5]1[n:1][c:2]([n:3][o:4]1)-[c:14]1[cH:15][cH:16][cH:17][c:18]2[nH:19][cH:20][cH:21][c:22]21|US10233176B2_0567
4.1.60|[N&H2&+0&D1:12]-[N&H1&+0&D2:11]-[c&H0&+0&D3:10](:[c:9]):[c:8].[c:7]:[c&H0&+0&D3:6](:[c:5])-[C&H0&+0&D3:4](-[c:3]:[c&H0&+0&D3:2](:[c:1])-O)=O>>[n&H0&+0&D2:12]1:[n&H0&+0&D3:11](-[c&H0&+0&D3:10](:[c:9]):[c:8]):[c&H0&+0&D3:2](:[c:1]):[c:3]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:6](:[c:7]):[c:5]|Cl.[NH2:1][NH:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[Cl:9])[Cl:10].O=[C:11]([c:12]1[cH:13][cH:14][c:15]([cH:16][c:17]1O)[OH:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][c:24]1[OH:25])[OH:26]>[Na+].CC([O-])=O>[OH:18][c:15]1[cH:16][c:17]2[c:12]([cH:13][cH:14]1)[c:11]([n:1][n:2]2-[c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[Cl:9])[Cl:10])-[c:19]1[cH:20][cH:21][c:22]([cH:23][c:24]1[OH:25])[OH:26]|US07241791B2_0290
4.1.12|[N&H2&+0&D1:12]-[c:11]:[n&H0&+0&D2:10]:[c:9].[c:8]:[c&H0&+0&D3:7](:[c:6])-[C&H0&+0&D3:5](-[C&H1&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Br)=O>>[n&H0&+0&D2:12]1:[c:11]:[n&H0&+0&D3:10](:[c:9]):[c&H0&+0&D3:4](:[c&H0&+0&D3:5]:1-[c&H0&+0&D3:7](:[c:8]):[c:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[CH:11](Br)[C:12](=O)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[NH2:19][c:20]1[n:21][cH:22][cH:23][s:24]1>[Na+].CCO.[O-]C(=O)O>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[c:12]([n:19][c:20]2[s:24][cH:23][cH:22][n:21]12)-[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|EP2593451B1_0261
1.3.7|[c:12]:[c&H0&+0&D3:11](:[c&H0&+0&D3:10](:[c:9])-[c&H0&+0&D3:8](:[c:7]):[c&H0&+0&D3:6](:[c:5])-[c&H0&+0&D3:4](:[n:3]):[n&H1&+0&D2:2]:[c:1])-Cl>>[c:12]:[c&H0&+0&D3:11]1:[n&H0&+0&D3:2](:[c:1]):[c&H0&+0&D3:4](:[n:3]):[c&H0&+0&D3:6](:[c:5]):[c&H0&+0&D3:8](:[c:7]):[c&H0&+0&D3:10]:1:[c:9]|[Cl:1][c:2]1[cH:3][cH:4][c:5]([c:6]([cH:7]1)-[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1Cl)-[c:14]1[n:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[nH:22]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[c:8]1[cH:9][cH:10][cH:11][cH:12][c:13]1[n:22]1[c:14]2[n:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21|
4.2.3|[N&H2&+0&D1:11]-[N&H1&+0&D2:10]-[C&H0&+0&D3:9](=[O&H0&+0&D1:8])-[c&H0&+0&D3:7](:[c:6]):[c:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](-O)=O>>[n&H0&+0&D2:11]1:[n&H0&+0&D2:10]:[c&H0&+0&D3:9](:[o&H0&+0&D2:8]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2])-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:5][CH2:6][N:7]([CH2:8]1)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[C:15](=[O:16])[NH:17][NH2:18].[CH3:19][CH2:20][CH2:21][CH2:22][O:23][c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[C:30](=O)O>CC(C)N(CC)C(C)C.CN1C=CN([CH2+]1Cl)C.F[P-](F)(F)(F)(F)F.ClCCl>[CH3:1][N:2]([CH3:3])[CH:4]1[CH2:5][CH2:6][N:7]([CH2:8]1)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)-[c:15]1[n:17][n:18][c:30]([o:16]1)-[c:27]1[cH:26][cH:25][c:24]([cH:29][cH:28]1)[O:23][CH2:22][CH2:21][CH2:20][CH3:19]|US20140073634A1_0929
4.1.8|[N&H2&+0&D1:11]-[N&H2&+0&D1:10].[c:9]:[c&H0&+0&D3:8](:[c:7])-[C&H0&+0&D3:6](-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)=O>>[n&H1&+0&D2:11]1:[n&H0&+0&D2:10]:[c&H0&+0&D3:6](:[c&H1&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:9]):[c:7]|O.[NH2:1][NH2:2].[O:3]=[C:4]([OH:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1[C:12](=O)[CH2:13][C:14](=O)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>O.Cl.CO.[Na][Na]>[O:3]=[C:4]([OH:5])[c:6]1[cH:7][cH:8][cH:9][cH:10][c:11]1-[c:12]1[cH:13][c:14]([nH:2][n:1]1)-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|EP1501515B1_0352
4.2.2|[N&H2&+0&D1:11]/[C&H0&+0&D3:10](=[N&H0&+0&D2:9]\O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[n:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[NH:11][S:12](=[O:13])(=[O:14])[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[C:21](/[NH2:22])=[N:23]/O.[CH3:24][C:25](=[O:26])[NH:27][c:28]1[cH:29][cH:30][cH:31][c:32]([n:33]1)[C:34](=[O:35])O>O=C(n1ccnc1)n1ccnc1.C1COCCO1.CN(C)C=O>[CH3:1][C:2](=[O:3])[NH:4][c:5]1[cH:6][cH:7][cH:8][c:9]([cH:10]1)[NH:11][S:12](=[O:13])(=[O:14])[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)-[c:21]1[n:22][c:34]([o:35][n:23]1)-[c:32]1[cH:31][cH:30][cH:29][c:28]([n:33]1)[NH:27][C:25]([CH3:24])=[O:26]|US20140073634A1_0501
4.1.48|[N&H1&+0&D1:10]=[C&H0&+0&D3:9](-[N&H2&+0&D1:8])-[N&H2&D1:7].[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:10]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D2:8]:[c&H0&+0&D3:9]:1-[N&H2&D1:7])-[c&H0&+0&D3:5](:[c:6]):[c:4]|Cl.CN(C)[CH:1]=[CH:2][C:3](=O)[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[O:10][CH2:11][CH:12]([OH:13])[CH2:14][N:15]1[CH2:16][CH2:17][N:18]([CH2:19][CH2:20]1)[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[Cl:27].[NH:28]=[C:29]([NH2:30])[NH2:31]>[Na+].Cl.CCO.C[O-]>[NH2:30][c:29]1[n:28][cH:1][cH:2][c:3]([n:31]1)-[c:4]1[cH:5][cH:6][cH:7][cH:8][c:9]1[O:10][CH2:11][CH:12]([OH:13])[CH2:14][N:15]1[CH2:16][CH2:17][N:18]([CH2:19][CH2:20]1)[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[Cl:27]|US04638067A
4.2.2|[N&H2&+0&D1:11]/[C&H0&+0&D3:10](=[N&H0&+0&D2:9]\O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][O:2][C:3](=[O:4])[C@@H:5]([CH3:6])[NH:7][S:8](=[O:9])(=[O:10])[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[C:17](=[O:18])O.[CH3:19][c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[C:26](/[NH2:27])=[N:28]/O>>[CH3:1][O:2][C:3](=[O:4])[C@@H:5]([CH3:6])[NH:7][S:8](=[O:9])(=[O:10])[c:11]1[cH:16][cH:15][c:14]([cH:13][cH:12]1)-[c:17]1[n:27][c:26]([n:28][o:18]1)-[c:23]1[cH:24][cH:25][c:20]([cH:21][cH:22]1)[CH3:19]|US10662164B2_0263
4.2.2|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[N&H0&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[o:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[o:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[NH2:1][C:2](=[N:3]O)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10].[CH3:11][c:12]1[cH:13][cH:14][o:15][c:16]1[C:17](=[O:18])O>c1ccccc1.O=S(Cl)Cl.O>[CH3:11][c:12]1[cH:13][cH:14][o:15][c:16]1-[c:17]1[n:1][c:2]([n:3][o:18]1)-[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10]|US08399451B2_0537
4.1.48|[N&H1&+0&D1:10]=[C&H0&+0&D3:9](-[N&H2&+0&D1:8])-[N&H2&D1:7].[c:6]:[c&H0&+0&D3:5](:[s:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:10]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D2:8]:[c&H0&+0&D3:9]:1-[N&H2&D1:7])-[c&H0&+0&D3:5](:[c:6]):[s:4]|[CH3:1][c:2]1[n:3][c:4]([c:5]([s:6]1)[C:7](=O)[CH:8]=[CH:9]N(C)C)[CH3:10].[NH:11]=[C:12]([NH2:13])[NH2:14]>>[CH3:1][c:2]1[n:3][c:4]([c:5]([s:6]1)-[c:7]1[cH:8][cH:9][n:11][c:12]([n:14]1)[NH2:13])[CH3:10]|US20080293716A1_0539
4.2.2|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[N&H0&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[o:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:7]):[o:6]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[cH:9][cH:10][c:11]([c:12]([cH:13]1)[F:14])[C:15](=[O:16])O.[CH3:17][c:18]1[cH:19][cH:20][c:21]([c:22]2[cH:23][c:24]([o:25][c:26]12)[C:27]([NH2:28])=[N:29]O)[CH3:30]>CCCP1(OP(OP(O1)(=O)CCC)(=O)CCC)=O.CN(C)C=O>[CH3:30][c:21]1[cH:20][cH:19][c:18]([c:26]2[o:25][c:24]([cH:23][c:22]12)-[c:27]1[n:29][o:16][c:15]([n:28]1)-[c:11]1[cH:10][cH:9][c:8]([cH:13][c:12]1[F:14])[C:6](=[O:7])[O:5][C:2]([CH3:1])([CH3:3])[CH3:4])[CH3:17]|US10752616B2_0789
4.2.3|[N&H2&+0&D1:11]-[N&H1&+0&D2:10]-[C&H0&+0&D3:9](=[O&H0&+0&D1:8])-[c&H0&+0&D3:7](:[c:6]):[n:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1](=O)-O>>[n&H0&+0&D2:11]1:[n&H0&+0&D2:10]:[c&H0&+0&D3:9](:[o&H0&+0&D2:8]:[c&H0&+0&D3:1]:1-[c&H0&+0&D3:3](:[c:4]):[c:2])-[c&H0&+0&D3:7](:[c:6]):[n:5]|[NH2:1][c:2]1[n:3][cH:4][c:5]([n:6][c:7]1[C:8](=[O:9])[NH:10][NH2:11])[Br:12].O=[C:13](O)[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20][Br:21]>BrP(Br)(c1ccccc1)(c1ccccc1)c1ccccc1.CC(C)N(CC)C(C)C.CC#N>[NH2:1][c:2]1[n:3][cH:4][c:5]([n:6][c:7]1-[c:8]1[n:10][n:11][c:13]([o:9]1)-[c:14]1[cH:15][cH:16][c:17]([cH:18][cH:19]1)[CH2:20][Br:21])[Br:12]|US20180271098A1_0210
4.2.2|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[N&H0&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][C:2]([CH3:3])([c:4]1[cH:5][c:6]2[cH:7][cH:8][cH:9][n:10][c:11]2[c:12]([cH:13]1)-[c:14]1[cH:15][c:16]([cH:17][cH:18][cH:19]1)[C:20](=[O:21])O)[S:22]([CH3:23])(=[O:24])=[O:25].[NH2:26][C:27](=[N:28]O)[c:29]1[cH:30][cH:31][c:32]([cH:33][cH:34]1)[F:35]>O.CN(C)C=O.O=C(n1ccnc1)n1ccnc1>[CH3:23][S:22](=[O:24])(=[O:25])[C:2]([CH3:1])([CH3:3])[c:4]1[cH:5][c:6]2[cH:7][cH:8][cH:9][n:10][c:11]2[c:12]([cH:13]1)-[c:14]1[cH:19][cH:18][cH:17][c:16]([cH:15]1)-[c:20]1[n:26][c:27]([n:28][o:21]1)-[c:29]1[cH:34][cH:33][c:32]([cH:31][cH:30]1)[F:35]|US20180016244A1_0205
4.1.48|[N&H1&+0&D1:10]=[C&H0&+0&D3:9](-[N&H2&+0&D1:8])-[N&H2&D1:7].[c:6]:[c&H0&+0&D3:5](:[n:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:10]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D2:8]:[c&H0&+0&D3:9]:1-[N&H2&D1:7])-[c&H0&+0&D3:5](:[c:6]):[n:4]|Cl.[CH3:1][c:2]1[n:3][cH:4][c:5]([n:6]1[CH3:7])[C:8](=O)[CH:9]=[CH:10]N(C)C.[NH:11]=[C:12]([NH2:13])[NH2:14]>[Na+].CCCCO.C[O-]>[CH3:1][c:2]1[n:3][cH:4][c:5]([n:6]1[CH3:7])-[c:8]1[cH:9][cH:10][n:11][c:12]([n:14]1)[NH2:13]|US20180344738A1_1833
4.2.2|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][CH:2]([CH3:3])[CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[C:11](=[O:12])O.[NH:13]=[C:14]([NH:15]O)[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[CH2:22][OH:23]>O.Cl.CCN=C=NCCCN(C)C.CN(C)C=O.On1nnc2ccccc21>[CH3:1][CH:2]([CH3:3])[CH2:4][c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[c:11]1[n:13][c:14]([n:15][o:12]1)-[c:16]1[cH:17][cH:18][c:19]([cH:20][cH:21]1)[CH2:22][OH:23]|US20090227641A1_0307
4.1.62|[N&H2&+0&D1:11]-[c:10]:[n&H1&+0&D2:9]:[n:8].[c:7]:[c&H0&+0&D3:6](:[c:5])-[C&H0&+0&D3:4](-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[O&H0&+0&D2:1]-C)=O)=O>>[n&H0&+0&D2:11]1:[c:10]:[n&H0&+0&D3:9](:[n:8]):[c&H0&+0&D3:2](:[c&H1&+0&D2:3]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:6](:[c:7]):[c:5])-[O&H1&+0&D1:1]|[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][n:6][nH:7][c:8]1[NH2:9].C[O:10][C:11](=O)[CH2:12][C:13](=O)[c:14]1[cH:15][n:16][cH:17][c:18]([cH:19]1)[Br:20]>CC(=O)O>[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][n:6][n:7]2[c:11]([cH:12][c:13]([n:9][c:8]12)-[c:14]1[cH:15][n:16][cH:17][c:18]([cH:19]1)[Br:20])[OH:10]|US09096605B2_0361
4.2.2|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[n:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[O:1]=[C:2](O)[c:3]1[cH:4][n:5][c:6]2[c:7]([cH:8][c:9]([cH:10][n:11]12)-[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[C:18]([F:19])([F:20])[F:21])[C:22]([F:23])([F:24])[F:25].[NH:26]=[C:27]([NH:28]O)[c:29]1[cH:30][cH:31][cH:32][c:33]([cH:34]1)[S:35]([NH2:36])(=[O:37])=[O:38]>>[NH2:36][S:35](=[O:37])(=[O:38])[c:33]1[cH:32][cH:31][cH:30][c:29]([cH:34]1)-[c:27]1[n:26][c:2]([o:1][n:28]1)-[c:3]1[cH:4][n:5][c:6]2[c:7]([cH:8][c:9]([cH:10][n:11]21)-[c:12]1[cH:17][cH:16][c:15]([cH:14][cH:13]1)[C:18]([F:19])([F:20])[F:21])[C:22]([F:23])([F:24])[F:25]|EP2222668B1_0348
4.2.2|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[s:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[s:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][c:2]1[s:3][c:4]([c:5]2[CH2:6][C@@H:7]3[C@H:8]([c:9]21)[C:10]3([CH3:11])[CH3:12])[C:13](=[O:14])O.[CH3:15][O:16][c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[O:23][CH3:24])[C:25](=[NH:26])[NH:27]O>CN(C)C(On1nnc2ccccc21)=[N+](C)C.CC(C)N(CC)C(C)C.CN(C)C=O.F[B-](F)(F)F>[CH3:15][O:16][c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[O:23][CH3:24])-[c:25]1[n:26][c:13]([o:14][n:27]1)-[c:4]1[s:3][c:2]([c:9]2[c:5]1[CH2:6][C@@H:7]1[C@H:8]2[C:10]1([CH3:11])[CH3:12])[CH3:1]|US08148410B2_0323
4.2.2|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[s:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:7]):[s:6]|[NH:1]=[C:2]([NH:3]O)[c:4]1[cH:5][cH:6][c:7]([s:8]1)[S:9]([NH2:10])(=[O:11])=[O:12].[O:13]=[C:14](O)[c:15]1[cH:16][n:17][n:18]2[c:19]([cH:20][c:21]([n:22][c:23]12)-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[Cl:30])[CH:31]1[CH2:32][CH2:33]1>>[NH2:10][S:9](=[O:11])(=[O:12])[c:7]1[cH:6][cH:5][c:4]([s:8]1)-[c:2]1[n:1][c:14]([o:13][n:3]1)-[c:15]1[cH:16][n:17][n:18]2[c:19]([cH:20][c:21]([n:22][c:23]12)-[c:24]1[cH:25][cH:26][c:27]([cH:28][cH:29]1)[Cl:30])[CH:31]1[CH2:32][CH2:33]1|US07504404B2_0343
4.2.2|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[n:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:7]):[n:6]|[NH:1]=[C:2]([NH:3]O)[c:4]1[n:5][cH:6][n:7]2[c:8]([cH:9][c:10]([n:11][c:12]12)-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[C:19]([F:20])([F:21])[F:22])[C:23]([F:24])([F:25])[F:26].[NH2:27][S:28](=[O:29])(=[O:30])[c:31]1[cH:32][cH:33][c:34]([cH:35][cH:36]1)[C:37](=[O:38])O>>[NH2:27][S:28](=[O:29])(=[O:30])[c:31]1[cH:36][cH:35][c:34]([cH:33][cH:32]1)-[c:37]1[n:1][c:2]([n:3][o:38]1)-[c:4]1[n:5][cH:6][n:7]2[c:8]([cH:9][c:10]([n:11][c:12]12)-[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[C:19]([F:20])([F:21])[F:22])[C:23]([F:24])([F:25])[F:26]|US20050075375A1_0793
4.1.62|[N&H2&+0&D1:11]-[c:10]:[n&H1&+0&D2:9]:[n:8].[c:7]:[c&H0&+0&D3:6](:[c:5])-[C&H0&+0&D3:4](-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[O&H0&+0&D2:1]-C)=O)=O>>[n&H1&+0&D2:11]1:[c:10]:[n&H0&+0&D3:9](:[n:8]):[c&H0&+0&D3:2](:[c&H1&+0&D2:3]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:6](:[c:7]):[c:5])=[O&H0&+0&D1:1]|C[O:1][C:2](=O)[CH2:3][C:4](=O)[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11].[CH3:12][O:13][c:14]1[n:15][nH:16][c:17]([c:18]1[C:19]#[N:20])[NH2:21]>CCCCO.Cc1ccc(cc1)S(=O)(=O)O>[CH3:12][O:13][c:14]1[n:15][n:16]2[c:2]([cH:3][c:4]([nH:21][c:17]2[c:18]1[C:19]#[N:20])-[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[Cl:11])=[O:1]|US20120277224A1_1807
4.2.2|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[N&H0&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[n:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)[C:9]([NH2:10])=[N:11]O.[O:12]=[C:13](O)[c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1>O=C(n1ccnc1)n1ccnc1.O=C=O.c1ccncc1>[CH3:1][O:2][c:3]1[cH:4][cH:5][cH:6][c:7]([cH:8]1)-[c:9]1[n:10][c:13]([o:12][n:11]1)-[c:14]1[cH:15][cH:16][cH:17][cH:18][n:19]1|US20100292233A1_0482
4.2.2|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[N&H0&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[n:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:7]):[n:6]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([cH:10][n:11]1)[C:12]([NH2:13])=[N:14]O.[CH3:15][CH:16]([CH3:17])[CH2:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[C:25](=[O:26])O>CN(C)C(On1nnc2c1cccc2)=[N+](C)C.On1nnc2c1cccc2.CC(C)N(CC)C(C)C.C1COCCO1.F[B-](F)(F)F>[CH3:15][CH:16]([CH3:17])[CH2:18][c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)-[c:25]1[n:13][c:12]([n:14][o:26]1)-[c:9]1[cH:10][n:11][c:6]([cH:7][n:8]1)[C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20100160369A1_0681
4.1.62|[N&H2&+0&D1:11]-[c:10]:[n&H0&+0&D2:9]:[c:8].[c:7]:[c&H0&+0&D3:6](:[c:5])-[C&H0&+0&D3:4](-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[O&H0&+0&D2:1]-C)=O)=O>>[n&H0&+0&D2:11]1:[c:10]:[n&H0&+0&D3:9](:[c:8]):[c&H0&+0&D3:2](:[c&H1&+0&D2:3]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:6](:[c:7]):[c:5])=[O&H0&+0&D1:1]|C[O:1][C:2](=O)[CH2:3][C:4](=O)[c:5]1[cH:6][cH:7][c:8]([c:9]([cH:10]1)[O:11][C:12]([F:13])([F:14])[F:15])[O:16][CH3:17].[NH2:18][c:19]1[cH:20][cH:21][c:22]([cH:23][n:24]1)[F:25]>>[CH3:17][O:16][c:8]1[cH:7][cH:6][c:5]([cH:10][c:9]1[O:11][C:12]([F:13])([F:14])[F:15])-[c:4]1[cH:3][c:2]([n:24]2[cH:23][c:22]([cH:21][cH:20][c:19]2[n:18]1)[F:25])=[O:1]|EP2307416B1_0061
4.2.2|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[n:2]):[n:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[n:2]):[n:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[NH:1]=[C:2]([NH:3]O)[c:4]1[cH:5][cH:6][n:7][c:8]([cH:9]1)[NH2:10].[O:11]=[C:12](O)[c:13]1[n:14][c:15]([cH:16][c:17]([n:18]1)[C:19]([F:20])([F:21])[F:22])-[c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[Cl:29]>>[NH2:10][c:8]1[cH:9][c:4]([cH:5][cH:6][n:7]1)-[c:2]1[n:1][c:12]([o:11][n:3]1)-[c:13]1[n:18][c:17]([cH:16][c:15]([n:14]1)-[c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[Cl:29])[C:19]([F:20])([F:21])[F:22]|US09790213B2_0289
4.2.2|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[N&H0&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[s:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:7]):[s:6]|[CH3:1][CH2:2][c:3]1[cH:4][c:5]([s:6][c:7]1[CH2:8][O:9][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][O:15]1)[C:16]([NH2:17])=[N:18]O.[O:19]=[C:20](O)[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[O:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>CCCC[N+](CCCC)(CCCC)CCCC.CCN=C=NCCCN(C)C.On1nnc2c1cccc2.C1CCOC1.Cl.[F-]>[CH3:1][CH2:2][c:3]1[cH:4][c:5]([s:6][c:7]1[CH2:8][O:9][CH:10]1[CH2:11][CH2:12][CH2:13][CH2:14][O:15]1)-[c:16]1[n:17][c:20]([o:19][n:18]1)-[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[O:27][c:28]1[cH:33][cH:32][cH:31][cH:30][cH:29]1|US07687491B2_0842
4.2.16|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[O&H0&+0&D1:9])-[c&H0&+0&D3:8](:[c:7]):[c:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[o&H0&+0&D2:9]:[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[c:3])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[NH2:1][C:2](=[O:3])[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.O=[C:10]([CH2:11]Br)[c:12]1[c:13]([cH:14][cH:15][cH:16][c:17]1[F:18])[F:19]>O.Cc1ccccc1C>[F:19][c:13]1[cH:14][cH:15][cH:16][c:17]([c:12]1-[c:10]1[cH:11][o:3][c:2]([n:1]1)-[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[F:18]|US08022063B2_0402
4.2.2|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[N&H0&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Cl>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[NH2:1][C:2](=[N:3]O)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[N+:10]([O-:11])=[O:12].[O:13]=[C:14](Cl)[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>C1COCCO1.CCOCC.FB(F)F>[O-:11][N+:10](=[O:12])[c:7]1[cH:6][cH:5][c:4]([cH:9][cH:8]1)-[c:2]1[n:1][c:14]([o:13][n:3]1)-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1|US20100292233A1_0534
4.3.3|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[S&H0&+0&D1:9])-[c&H0&+0&D3:8](:[c:7]):[c:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Cl)=O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[s&H0&+0&D2:9]:[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[c:3])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][C:2]1([CH2:3][CH2:4][C:5]([c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]21)[C:12](=O)[CH2:13]Cl)([CH3:14])[CH3:15])[CH3:16].[CH3:17][O:18][C:19](=[O:20])[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[C:27]([NH2:28])=[S:29]>O.CC(C)O.c1ccncc1>[CH3:17][O:18][C:19](=[O:20])[c:21]1[cH:26][cH:25][c:24]([cH:23][cH:22]1)-[c:27]1[n:28][c:12]([cH:13][s:29]1)-[c:8]1[cH:9][cH:10][c:11]2[c:6]([cH:7]1)[C:5]([CH2:4][CH2:3][C:2]2([CH3:1])[CH3:16])([CH3:14])[CH3:15]|US20160031888A1_0657
4.3.3|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[S&H0&+0&D1:9])-[c&H0&+0&D3:8](:[c:7]):[n:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[s&H0&+0&D2:9]:[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[c:3])-[c&H0&+0&D3:8](:[c:7]):[n:6]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=O)[CH2:10]Br.[NH2:11][C:12](=[S:13])[c:14]1[cH:15][c:16]2[c:17]([n:18][cH:19][n:20][c:21]2[nH:22]1)[NH:23][c:24]1[cH:25][cH:26][cH:27][c:28]([cH:29]1)[Cl:30]>CO>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][s:13][c:12]([n:11]1)-[c:14]1[cH:15][c:16]2[c:17]([n:18][cH:19][n:20][c:21]2[nH:22]1)[NH:23][c:24]1[cH:25][cH:26][cH:27][c:28]([cH:29]1)[Cl:30]|EP2445915B1_0188
4.1.12|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H2&+0&D1:9])-[c&H0&+0&D3:8](:[c:7]):[c:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H1&+0&D2:11]1:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](:[n&H0&+0&D2:9]:[c&H0&+0&D3:10]:1-[c&H0&+0&D3:8](:[c:7]):[c:6])-[c&H0&+0&D3:4](:[c:5]):[c:3]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[C:8](=[NH:9])[NH2:10].O=[C:11]([CH2:12]Br)[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>ClC(Cl)Cl>[CH3:1][c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:10][c:11]([cH:12][nH:9]1)-[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1|EP3750897A1_0168
4.1.12|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H2&+0&D1:9])-[c&H0&+0&D3:8](:[c:7]):[c:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:11]1:[c&H1&+0&D2:1]:[c&H0&+0&D3:2](:[n&H1&+0&D2:9]:[c&H0&+0&D3:10]:1-[c&H0&+0&D3:8](:[c:7]):[c:6])-[c&H0&+0&D3:4](:[c:5]):[c:3]|[NH:1]=[C:2]([NH2:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[F:10].O=[C:11]([CH2:12]Br)[c:13]1[cH:14][cH:15][c:16]([cH:17][cH:18]1)[Cl:19]>O=C(O[K])O[K]>[F:10][c:7]1[cH:8][cH:9][c:4]([cH:5][cH:6]1)-[c:2]1[n:1][cH:12][c:11]([nH:3]1)-[c:13]1[cH:18][cH:17][c:16]([cH:15][cH:14]1)[Cl:19]|US20200165279A1_0326
4.2.2|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[N&H0&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[s:1])-Cl>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[s:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[NH2:1][C:2](=[N:3]O)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[Cl:10].[O:11]=[C:12](Cl)[c:13]1[s:14][cH:15][cH:16][c:17]1[Cl:18]>C1COCCO1.CCOCC.FB(F)F>[Cl:10][c:7]1[cH:6][cH:5][c:4]([cH:9][cH:8]1)-[c:2]1[n:1][c:12]([o:11][n:3]1)-[c:13]1[s:14][cH:15][cH:16][c:17]1[Cl:18]|US09040711B2_0066
4.3.3|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[S&H0&+0&D1:9])-[c&H0&+0&D3:8](:[c:7]):[c:6].[c:5]:[c&H0&+0&D3:4](:[c:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[s&H0&+0&D2:9]:[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[c:3])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[c:6]1[cH:7][cH:8][c:9]2[cH:10][c:11]([c:12]([o:13][c:14]2[cH:15]1)=[O:16])[C:17]([NH2:18])=[S:19].O=[C:20]([CH2:21]Br)[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1>CCN(CC)CC.CC(C)O>[CH3:5][CH2:4][N:3]([CH2:2][CH3:1])[c:6]1[cH:7][cH:8][c:9]2[cH:10][c:11]([c:12]([o:13][c:14]2[cH:15]1)=[O:16])-[c:17]1[n:18][c:20]([cH:21][s:19]1)-[c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1|US05643932A
4.2.2|[N&H1&+0&D1:11]=[C&H0&+0&D3:10](-[N&H1&+0&D2:9]-O)-[c&H0&+0&D3:8](:[c:7]):[c:6].[O&H0&+0&D1:5]=[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Cl>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:9]:[o&H0&+0&D2:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][CH2:8][n:9]1[cH:10][cH:11][c:12]2[c:13]1[n:14][cH:15][cH:16][c:17]2[C:18](=[NH:19])[NH:20]O.[N:21]#[C:22][c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[C:29](=[O:30])Cl>c1ccncc1.CC#N>[CH3:1][Si:2]([CH3:3])([CH3:4])[CH2:5][CH2:6][O:7][CH2:8][n:9]1[cH:10][cH:11][c:12]2[c:13]1[n:14][cH:15][cH:16][c:17]2-[c:18]1[n:19][c:29]([o:30][n:20]1)-[c:27]1[cH:26][cH:25][cH:24][c:23]([cH:28]1)[C:22]#[N:21]|US09278910B2_0460
4.3.3|[N&H2&+0&D1:11]-[C&H0&+0&D3:10](=[S&H0&+0&D1:9])-[c&H0&+0&D3:8](:[c:7]):[c:6].[c:5]:[c&H0&+0&D3:4](:[n:3])-[C&H0&+0&D3:2](-[C&H2&+0&D2:1]-Br)=O>>[n&H0&+0&D2:11]1:[c&H0&+0&D3:10](:[s&H0&+0&D2:9]:[c&H1&+0&D2:1]:[c&H0&+0&D3:2]:1-[c&H0&+0&D3:4](:[c:5]):[n:3])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][CH2:2][O:3][c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[O:10][CH2:11][CH3:12])[C:13]([NH2:14])=[S:15].[CH3:16][CH2:17][O:18][C:19](=[O:20])[c:21]1[n:22][c:23]([cH:24][cH:25][c:26]1[OH:27])[C:28](=O)[CH2:29]Br>CCO>[CH3:1][CH2:2][O:3][c:4]1[cH:5][c:6]([cH:7][cH:8][c:9]1[O:10][CH2:11][CH3:12])-[c:13]1[n:14][c:28]([cH:29][s:15]1)-[c:23]1[cH:24][cH:25][c:26]([c:21]([n:22]1)[C:19](=[O:20])[O:18][CH2:17][CH3:16])[OH:27]|EP0600092A1_0135
4.1.72|[N&H2&+0&D1:11]-[c:10]:[n&H0&+0&D2:9]:[n&H1&+0&D2:8]:[c:7].[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:11]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D3:9](:[c:10]:1):[n&H0&+0&D2:8]:[c:7])-[c&H0&+0&D3:5](:[c:6]):[c:4]|CN(C)[CH:1]=[CH:2][C:3](=O)[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[NH2:10][c:11]1[cH:12][cH:13][nH:14][n:15]1>CC(=O)O>[cH:7]1[cH:6][cH:5][c:4]([cH:9][cH:8]1)-[c:3]1[cH:2][cH:1][n:10][c:11]2[cH:12][cH:13][n:14][n:15]12|US20070219186A1_1003
4.1.62|[N&H2&+0&D1:11]-[c:10]:[n&H1&+0&D2:9]:[n:8].[c:7]:[c&H0&+0&D3:6](:[c:5])-[C&H0&+0&D3:4](-[C&H2&+0&D2:3]-[C&H0&+0&D3:2](-[O&H0&+0&D2:1]-C-C)=O)=O>>[n&H1&+0&D2:11]1:[c:10]:[n&H0&+0&D3:9](:[n:8]):[c&H0&+0&D3:4](:[c&H1&+0&D2:3]:[c&H0&+0&D3:2]:1=[O&H0&+0&D1:1])-[c&H0&+0&D3:6](:[c:7]):[c:5]|CC[O:1][C:2](=O)[CH2:3][C:4](=O)[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH3:12].[CH3:13][c:14]1[n:15][nH:16][c:17]([c:18]1-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25])[NH2:26]>c1ccncc1>[CH3:12][O:11][c:8]1[cH:9][cH:10][c:5]([cH:6][cH:7]1)-[c:4]1[cH:3][c:2]([nH:26][c:17]2[c:18]([c:14]([n:15][n:16]12)[CH3:13])-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25])=[O:1]|US08975264B2_0485
4.1.61|[C:11]-[C&H1&+0&D3:10](-[C&H0&+0&D3:9](-[C:8])=O)-[C&H0&+0&D3:7](-[O&H0&+0&D2:6]-C)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:11]-[c&H0&+0&D3:10]1:[c&H0&+0&D3:9](-[C:8]):[n&H1&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7]:1=[O&H0&+0&D1:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|C[O:1][C:2](=O)[CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][C:8]1=O.[NH2:9][NH:10][c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1>O.CC(=O)O.Cc1ccccc1>[O:1]=[c:2]1[c:3]2[CH2:4][CH2:5][CH2:6][CH2:7][c:8]2[nH:9][n:10]1-[c:11]1[cH:16][cH:15][cH:14][cH:13][cH:12]1|US20070049574A1_0509
4.1.48|[C:11]-[C&H0&+0&D3:10](-[C&H0&+0&D3:9](-[C:8])=[C&H1&+0&D2:7]-N(-C)-C)=O.[N&H1&+0&D1:6]=[C&H0&+0&D3:5](-[N&H2&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H1&+0&D2:7]:[c&H0&+0&D3:9]:1-[C:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([C:12]([CH2:13]1)=[CH:14]N(C)C)=O.[NH:15]=[C:16]([NH2:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.O.Cl>CC[O-].CCO.[Na+]>[CH3:1][C:2]([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][c:11]2[n:17][c:16]([n:15][cH:14][c:12]2[CH2:13]1)-[c:18]1[cH:23][cH:22][cH:21][cH:20][cH:19]1|US10000484B2_0301
4.1.60|[N&H2&+0&D1:11]-[N&H1&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[n:7].[c:6]:[c&H0&+0&D3:5](:[n:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:11]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D3:10]:1-[c&H0&+0&D3:9](:[c:8]):[n:7])-[c&H0&+0&D3:5](:[c:6]):[n:4]|CN(C)[CH:1]=[CH:2][C:3](=O)[c:4]1[n:5][n:6]([cH:7][cH:8][c:9]1=[O:10])-[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[C:17]([F:18])([F:19])[F:20].[NH2:21][NH:22][c:23]1[cH:24][cH:25][cH:26][cH:27][n:28]1>CCN(CC)CC.CCO.O>[O:10]=[c:9]1[cH:8][cH:7][n:6]([n:5][c:4]1-[c:3]1[cH:2][cH:1][n:21][n:22]1-[c:23]1[cH:24][cH:25][cH:26][cH:27][n:28]1)-[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[C:17]([F:18])([F:19])[F:20]|US09187455B2_0233
4.1.48|[C:11]-[C&H0&+0&D3:10](=[C&H1&+0&D2:9]-N(-C)-C)-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[s:5])=O.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N&H2&+0&D1:2])-[N:1]>>[C:11]-[c&H0&+0&D3:10]1:[c&H1&+0&D2:9]:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](:[n&H0&+0&D2:2]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[s:5])-[N:1]|Cl.CN(C)[CH:1]=[C:2]([C:3]#[N:4])[C:5](=O)[c:6]1[cH:7][cH:8][c:9]([s:10]1)[Br:11].[NH:12]=[C:13]([NH2:14])[NH:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][NH:21][C:22]1=[O:23]>CN1CCCC1=O.CO.O=C(O[Cs])O[Cs]>[N:4]#[C:3][c:2]1[cH:1][n:12][c:13]([n:14][c:5]1-[c:6]1[cH:7][cH:8][c:9]([s:10]1)[Br:11])[NH:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][NH:21][C:22]1=[O:23]|US20110092490A1_0259
4.1.48|[C:11]/[C&H0&+0&D3:10](=[C&H1&+0&D2:9]\N(-C)-C)-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N&H2&+0&D1:2])-[N:1]>>[C:11]-[c&H0&+0&D3:10]1:[c&H1&+0&D2:9]:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](:[n&H0&+0&D2:2]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5])-[N:1]|[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[NH:11][C:12](=[NH:13])[NH2:14].CN(C)/[CH:15]=[C:16]1\[CH2:17][C:18]([NH:19][c:20]2[cH:21][cH:22][c:23]([cH:24][c:25]2[C:26]1=O)[I:27])=[O:28]>CCO.O=C(O[K])O[K]>[CH3:1][O:2][c:3]1[cH:4][c:5]([cH:6][cH:7][c:8]1[O:9][CH3:10])[NH:11][c:12]1[n:13][cH:15][c:16]2[CH2:17][C:18]([NH:19][c:20]3[cH:21][cH:22][c:23]([cH:24][c:25]3-[c:26]2[n:14]1)[I:27])=[O:28]|US08357694B2_1179
4.1.48|[C:11]-[C&H0&+0&D3:10](=[C&H1&+0&D2:9]-N(-C)-C)-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N&H2&+0&D1:2])-[N:1]>>[C:11]-[c&H0&+0&D3:10]1:[c&H1&+0&D2:9]:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](:[n&H0&+0&D2:2]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5])-[N:1]|[CH3:1][O:2][CH2:3][C:4](=[CH:5]N(C)C)[C:6](=O)[c:7]1[cH:8][nH:9][c:10]([cH:11]1)[C:12](=[O:13])[NH:14][C@H:15]([CH2:16][OH:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[NH:24]=[C:25]([NH2:26])[NH:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>CCOC(C)=O.CC(=O)N(C)C>[CH3:1][O:2][CH2:3][c:4]1[cH:5][n:24][c:25]([n:26][c:6]1-[c:7]1[cH:8][nH:9][c:10]([cH:11]1)[C:12](=[O:13])[NH:14][C@H:15]([CH2:16][OH:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[NH:27][c:28]1[cH:33][cH:32][cH:31][cH:30][cH:29]1|EP2373657B1_0155
4.1.60|[N&H2&+0&D1:11]-[N&H1&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[n:7].[c:6]:[c&H0&+0&D3:5](:[c:4])-[C&H0&+0&D3:3](/[C&H1&+0&D2:2]=[C&H1&+0&D2:1]/N(-C)-C)=O>>[n&H0&+0&D2:11]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D3:10]:1-[c&H0&+0&D3:9](:[c:8]):[n:7])-[c&H0&+0&D3:5](:[c:6]):[c:4]|CN(C)/[CH:1]=[CH:2]/[C:3](=O)[c:4]1[cH:5][cH:6][cH:7][c:8]([cH:9]1)[C:10]([F:11])([F:12])[F:13].[CH3:14][S:15][c:16]1[n:17][cH:18][cH:19][c:20]([n:21]1)[NH:22][NH2:23]>>[CH3:14][S:15][c:16]1[n:17][cH:18][cH:19][c:20]([n:21]1)-[n:22]1[n:23][cH:1][cH:2][c:3]1-[c:4]1[cH:9][c:8]([cH:7][cH:6][cH:5]1)[C:10]([F:11])([F:12])[F:13]|US08987461B2_0671
4.1.60|[N&H2&+0&D1:11]-[N&H1&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[c:7].[c:6]:[c&H0&+0&D3:5](:[n:4])-[C&H0&+0&D3:3](-[C&H1&+0&D2:2]=[C&H1&+0&D2:1]-N(-C)-C)=O>>[n&H0&+0&D2:11]1:[c&H1&+0&D2:1]:[c&H1&+0&D2:2]:[c&H0&+0&D3:3](:[n&H0&+0&D3:10]:1-[c&H0&+0&D3:9](:[c:8]):[c:7])-[c&H0&+0&D3:5](:[c:6]):[n:4]|CN(C)[CH:1]=[CH:2][C:3](=O)[c:4]1[n:5][n:6]([cH:7][cH:8][c:9]1=[O:10])-[c:11]1[cH:12][cH:13][cH:14][c:15]([cH:16]1)[OH:17].[NH2:18][NH:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>CO>[O:10]=[c:9]1[cH:8][cH:7][n:6]([n:5][c:4]1-[c:3]1[cH:2][cH:1][n:18][n:19]1-[c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1)-[c:11]1[cH:16][c:15]([cH:14][cH:13][cH:12]1)[OH:17]|EP2373641B1_0542
4.1.22|[N&H2&+0&D1:12]-[c&H0&+0&D3:11](:[c:10]):[c:9].[c:8]:[c&H0&+0&D3:7](:[c&H0&+0&D3:6](:[c:5])-[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2](:[c:1])-Br)-Br>>[n&H0&+0&D3:12]1(-[c&H0&+0&D3:11](:[c:10]):[c:9]):[c&H0&+0&D3:7](:[c:8]):[c&H0&+0&D3:6](:[c:5]):[c&H0&+0&D3:4](:[c:3]):[c&H0&+0&D3:2]:1:[c:1]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH2:8])[CH3:9].Br[c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]1-[c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1Br>>[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1-[n:8]1[c:10]2[cH:11][cH:12][cH:13][cH:14][c:15]2[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21)[CH3:9]|
4.2.2|[O&H0&+0&D1:11]=[C&H0&+0&D3:10](-[c&H0&+0&D3:9](:[c:8]):[c:7])-O.[c:6]:[c&H0&+0&D3:5](:[c:4])/[C&H0&+0&D3:3](=[N&H0&+0&D2:2]/[#1])-[N&H1&+0&D2:1]-O>>[o&H0&+0&D2:11]1:[n&H0&+0&D2:1]:[c&H0&+0&D3:3](:[n&H0&+0&D2:2]:[c&H0&+0&D3:10]:1-[c&H0&+0&D3:9](:[c:8]):[c:7])-[c&H0&+0&D3:5](:[c:6]):[c:4]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH2:7][c:8]1[cH:9][nH:10][c:11]2[c:12]1[cH:13][cH:14][cH:15][c:16]2[C:17](=[N:18]/[H])/[NH:19]O.[CH3:20][CH:21]([CH3:22])[O:23][c:24]1[n:25][cH:26][c:27]([cH:28][c:29]1[Cl:30])[C:31](=[O:32])O>CCCC[N+](CCCC)(CCCC)CCCC.CCN=C=NCCCN(C)C.On1nnc2c1cccc2.C1CCOC1.[F-]>[CH3:20][CH:21]([CH3:22])[O:23][c:24]1[n:25][cH:26][c:27]([cH:28][c:29]1[Cl:30])-[c:31]1[n:18][c:17]([n:19][o:32]1)-[c:16]1[cH:15][cH:14][cH:13][c:12]2[c:11]1[nH:10][cH:9][c:8]2[CH2:7][CH2:6][C:4](=[O:5])[O:3][CH2:2][CH3:1]|US20120101134A1_0300
4.1.48|[C:11]-[C&H0&+0&D3:10](=[N&H1&+0&D1:9])-[N&H2&+0&D1:8].[C:7]-[C&H0&+0&D3:6](=[C&H1&+0&D2:5]-N(-C)-C)-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D2:9]:[c&H1&+0&D2:5]:[c&H0&+0&D3:6](-[C:7]):[c&H0&+0&D3:4](:[n&H0&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|Cl.[CH3:1][CH2:2][CH2:3][C:4](=[NH:5])[NH2:6].CN(C)[CH:7]=[C:8]1[CH2:9][C:10]([NH:11][c:12]2[cH:13][cH:14][cH:15][cH:16][c:17]2[C:18]1=O)=[O:19]>>[CH3:1][CH2:2][CH2:3][c:4]1[n:5][cH:7][c:8]2[CH2:9][C:10]([NH:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3-[c:18]2[n:6]1)=[O:19]|US09682941B2_0306
4.1.4|[C:12]-[N&H0&+0&D2:11]=[N&H0&+&D2:10]=[N&H0&-&D1:9].[c:8]:[c&H0&+0&D3:7](:[c:6])-[C&H0&+0&D2:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:12]-[n&H0&+0&D3:11]1:[c&H0&+0&D3:5](:[c&H0&+0&D3:4](:[n&H0&+0&D2:9]:[n&H0&+0&D2:10]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:7](:[c:8]):[c:6]|[CH3:1][O:2][C:3](=[O:4])[C@@H:5]1[CH2:6][C@H:7]([CH2:8][N:9]1[C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[N:17]=[N+:18]=[N-:19].[C:20](#[C:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1>Cc1ccccc1C>[CH3:1][O:2][C:3](=[O:4])[C@@H:5]1[CH2:6][C@H:7]([CH2:8][N:9]1[C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[n:17]1[n:18][n:19][c:21]([c:20]1-[c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)-[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1|US20200188370A1_0906
1.3.8|[C:12]-[C&H0&+0&D3:11](=[C&H1&+0&D2:10]-[N&H1&+0&D2:9]-[c&H0&+0&D3:8](:[c:7]):[c:6])-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[c:1])-F>>[C:12]-[c&H0&+0&D3:11]1:[c&H1&+0&D2:10]:[n&H0&+0&D3:9](:[c&H0&+0&D3:2](:[c:1]):[c:3]:[c&H0&+0&D3:5]:1=[O&H0&D1:4])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[CH:7][NH:8][c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[F:15])[F:16])[C:17](=[O:18])[c:19]1[c:20]([c:21]([c:22]([c:23]([c:24]1[CH3:25])[F:26])[F:27])[F:28])F>C1CCOC1.[NaH]>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][n:8]([c:20]2[c:21]([c:22]([c:23]([c:24]([c:19]2[c:17]1=[O:18])[CH3:25])[F:26])[F:27])[F:28])-[c:9]1[cH:10][cH:11][c:12]([cH:13][c:14]1[F:15])[F:16]|US20070213339A1_0551
4.1.8|[C&H3&D1:11]-[C&H0&+0&D3:10](-[C&H1&+0&D3:9](-[C:8])-[C&H0&+0&D3:7](-[C&H3&D1:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D3:4](:[n&H0&+0&D2:5]:[c&H0&+0&D3:7](-[C&H3&D1:6]):[c&H0&+0&D3:9]:1-[C:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=O)[CH:3]([CH2:4][C:5](=[O:6])[O:7][CH3:8])[C:9]([CH3:10])=O.[NH2:11][NH:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1>CCO.CC(=O)CC(C)=O.CC(=O)O.COC(=O)CBr.CN(C)C=O.[H][H].[NaH]>[CH3:8][O:7][C:5](=[O:6])[CH2:4][c:3]1[c:2]([n:11][n:12]([c:9]1[CH3:10])-[c:13]1[cH:18][cH:17][cH:16][cH:15][cH:14]1)[CH3:1]|EP2155685B1_0129
4.1.59|[C&H3&D1:11]-[C&H1&+0&D3:10](-[C&H0&+0&D2:9]#[N&H0&+0&D1:8])-[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[c:4])=O.[C:3]-[N&H1&+0&D2:2]-[N&H2&+0&D1:1]>>[C&H3&D1:11]-[c&H0&+0&D3:10]1:[c&H0&+0&D3:9](-[N&H2&+0&D1:8]):[n&H0&+0&D3:2](-[C:3]):[n&H0&+0&D2:1]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:6](:[c:5]):[c:4]|Cl.Cl.[CH3:1][CH:2]([C:3]#[N:4])[C:5](=O)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[C:12]#[N:13].[NH2:14][NH:15][CH2:16][CH:17]1[CH2:18][CH2:19]1>CC(C)O>[CH3:1][c:2]1[c:5]([n:14][n:15]([c:3]1[NH2:4])[CH2:16][CH:17]1[CH2:18][CH2:19]1)-[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[C:12]#[N:13]|US20200055842A1_2189
4.1.48|[C:12]-[C&H0&+0&D3:11](-[C&H2&+0&D2:10]-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[c:6])=O)=O.[N&H2&+0&D1:5]-[c:4]:[n&H0&+0&D2:3]:[n&H1&+0&D2:2]:[c:1]>>[C:12]-[c&H0&+0&D3:11]1:[c&H1&+0&D2:10]:[c&H0&+0&D3:9](:[n&H0&+0&D2:5]:[c:4]:[n&H0&+0&D3:3]:1:[n&H0&+0&D2:2]:[c:1])-[c&H0&+0&D3:8](:[c:7]):[c:6]|O=[C:1]([CH2:2][C:3](=O)[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[C:10]([F:11])([F:12])[F:13])[C:14]([F:15])([F:16])[F:17].[NH2:18][c:19]1[n:20][nH:21][cH:22][c:23]1[Br:24]>CC(=O)O.O>[F:11][C:10]([F:12])([F:13])[c:7]1[cH:6][cH:5][c:4]([cH:9][cH:8]1)-[c:3]1[cH:2][c:1]([n:20]2[n:21][cH:22][c:23]([c:19]2[n:18]1)[Br:24])[C:14]([F:15])([F:16])[F:17]|US20140038989A1_0270
4.1.59|[C&H3&D1:11]-[C&H0&+0&D3:10](=[C&H0&+0&D3:9](-[C:8])-[C&H0&+0&D2:7]#[N&H0&+0&D1:6])-O-C-C.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7](-[N&H2&+0&D1:6]):[c&H0&+0&D3:9]:1-[C:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|CCO[C:1]([CH3:2])=[C:3]([C:4]#[N:5])[C:6](=[O:7])[O:8][CH3:9].[NH2:10][NH:11][c:12]1[c:13]([cH:14][c:15]([cH:16][c:17]1[Cl:18])[Cl:19])[Cl:20]>CCN(CC)CC.CC(=O)O.ClCCl.O>[CH3:9][O:8][C:6](=[O:7])[c:3]1[c:1]([n:10][n:11]([c:4]1[NH2:5])-[c:12]1[c:13]([cH:14][c:15]([cH:16][c:17]1[Cl:18])[Cl:19])[Cl:20])[CH3:2]|US20200247800A1_0741
4.2.16|[C:12]-[C&H1&+0&D3:11](-[N&H1&+0&D2:10]-[C&H0&+0&D3:9](=[O&H0&+0&D1:8])-[c&H0&+0&D3:7](:[c:6]):[c:5])-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:10]:[c&H0&+0&D3:9](:[o&H0&+0&D2:8]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]([NH:8][C:9](=[O:10])[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[C:17](=O)[c:18]1[cH:19][cH:20][s:21][cH:22]1>CN(C)C=O.O=P(Cl)(Cl)Cl>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[n:8][c:9]([o:10][c:17]1-[c:18]1[cH:19][cH:20][s:21][cH:22]1)-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1|EP0761658A1_0149
1.2.18|[C:11]-[C&H1&+0&D3:10](-[C&H0&+0&D3:9](-[C:8])=O)-[C&H0&+0&D3:7](=[O&H0&D1:6])-[N&H0&+0&D3:5](-[N&H1&+0&D2:4]-C(=O)-O-C(-C)(-C)-C)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:11]-[c&H0&+0&D3:10]1:[c&H0&+0&D3:9](-[C:8]):[n&H1&+0&D2:4]:[n&H0&+0&D3:5](:[c&H0&+0&D3:7]:1=[O&H0&D1:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|CC(C)(C)OC(=O)[NH:1][N:2]([C:3](=[O:4])[CH:5]1[C:6]([C@@:7]2([CH2:8][CH2:9][C@H:10]1[C:11]2([CH3:12])[CH3:13])[CH3:14])=O)[c:15]1[cH:16][cH:17][c:18]([cH:19][c:20]1[Cl:21])[F:22]>O=C(O)C(F)(F)F.ClCCl>[CH3:12][C:11]1([C@@H:10]2[CH2:9][CH2:8][C@:7]1([c:6]1[nH:1][n:2]([c:3]([c:5]12)=[O:4])-[c:15]1[cH:16][cH:17][c:18]([cH:19][c:20]1[Cl:21])[F:22])[CH3:14])[CH3:13]|EP1924563B1_0121
4.1.14|[C:12]-[N&H2&+0&D1:11].[c:10]:[c&H0&+0&D3:9](:[c:8])-[C&H0&+0&D3:7](-[C&H2&+0&D2:6]-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)=O>>[C:12]-[n&H0&+0&D3:11]1:[c&H0&+0&D3:4](:[c&H1&+0&D2:5]:[c&H1&+0&D2:6]:[c&H0&+0&D3:7]:1-[c&H0&+0&D3:9](:[c:10]):[c:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[cH:12]1)[C:13](=O)[CH2:14][CH2:15][C:16](=O)[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1.[NH2:23][CH2:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>ClCCl>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[cH:12]1)-[c:13]1[cH:14][cH:15][c:16]([n:23]1[CH2:24][c:25]1[cH:30][cH:29][cH:28][cH:27][cH:26]1)-[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1|US20140094465A1_0540
4.1.12|[C:12]-[C&H0&+0&D3:11](=[N&H0&+0&D2:10]-O)-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[c:6])=O.[N&H2&+0&D1:5]-[C&H2&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:10]:[c&H0&+0&D3:4](:[n&H1&+0&D2:5]:[c&H0&+0&D3:9]:1-[c&H0&+0&D3:8](:[c:7]):[c:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=[N:7]O)[C:8](=O)[c:9]1[cH:10][cH:11][c:12]([cH:13][cH:14]1)[CH3:15].[NH2:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]21>O.Cc1ccccc1C>[CH3:15][c:12]1[cH:13][cH:14][c:9]([cH:10][cH:11]1)-[c:8]1[nH:16][c:17]([n:7][c:6]1[C:4](=[O:5])[O:3][CH2:2][CH3:1])-[c:18]1[cH:19][cH:20][cH:21][c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]21|US06288061B1
4.1.62|[C:11]-[C&H0&+0&D3:10](-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](=[O&H0&D1:7])-O-C)=O.[N&H1&+0&D1:6]=[C&H0&+0&D3:5](-[N&H2&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D2:6]:[c&H0&+0&D3:5](:[n&H1&+0&D2:4]:[c&H0&+0&D3:8](=[O&H0&D1:7]):[c&H1&+0&D2:9]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][CH2:3][CH2:4][C:5](=O)[CH2:6][C:7](=[O:8])OC.[NH:9]=[C:10]([NH2:11])[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[F:18]>[Na+].CC[O-].CCO>[CH3:1][CH2:2][CH2:3][CH2:4][c:5]1[cH:6][c:7]([nH:11][c:10]([n:9]1)-[c:12]1[cH:13][cH:14][cH:15][c:16]([cH:17]1)[F:18])=[O:8]|EP3515903B1_0191
4.3.3|[C:12]-[C&H0&+0&D3:11](-[N&H2&+0&D1:10])=[S&H0&+0&D1:9].[c:8]:[c&H0&+0&D3:7](:[n:6])-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:10]:[c&H0&+0&D3:4](:[c&H0&+0&D3:5](:[s&H0&+0&D2:9]:1)-[c&H0&+0&D3:7](:[c:8]):[n:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)[C:14](=O)[CH2:15][c:16]1[cH:17][cH:18][n:19][c:20]([n:21]1)[Cl:22].[CH3:23][CH:24]([CH3:25])[C:26]([NH2:27])=[S:28]>O=S(=O)(Nc1cccc(c1)-c1nc(sc1-c1ccnc(n1)Cl)N1CCCC1)c1c(cccc1F)F>[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][cH:10][cH:11][c:12]([cH:13]1)-[c:14]1[n:27][c:26]([s:28][c:15]1-[c:16]1[cH:17][cH:18][n:19][c:20]([n:21]1)[Cl:22])[CH:24]([CH3:23])[CH3:25]|US20190263796A1_0254
4.3.3|[N&H2&+0&D1:12]-[C&H0&+0&D3:11](-[N:10])=[S&H0&+0&D1:9].[c:8]:[c&H0&+0&D3:7](:[n:6])-[C&H2&+0&D2:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[n&H0&+0&D2:12]1:[c&H0&+0&D3:11](-[N:10]):[s&H0&+0&D2:9]:[c&H0&+0&D3:5](:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:7](:[c:8]):[n:6]|[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][cH:10][cH:11][c:12]([c:13]1[F:14])[C:15](=O)[CH2:16][c:17]1[cH:18][cH:19][n:20][c:21]([n:22]1)[Cl:23].[NH2:24][C:25](=[S:26])[N:27]1[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1>O.CC(=O)N(C)C.O=C1CCC(N1Br)=O>[CH2:1]=[CH:2][CH2:3][O:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][cH:10][cH:11][c:12]([c:13]1[F:14])-[c:15]1[n:24][c:25]([s:26][c:16]1-[c:17]1[cH:18][cH:19][n:20][c:21]([n:22]1)[Cl:23])[N:27]1[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1|US20110098296A1_0849
4.1.8|[N&H2&+0&D1:12]-[N&H2&+0&D1:11].[c:10]:[c&H0&+0&D3:9](:[c:8])-[C&H0&+0&D3:7](-[C&H1&+0&D3:6]1-[C:5]-[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H0&+0&D3:1]-1=O)=O>>[n&H0&+0&D2:12]1:[n&H1&+0&D2:11]:[c&H0&+0&D3:1]2:[c&H0&+0&D3:6](-[C:5]-[c:4]:[c&H0&+0&D3:3]-2:[c:2]):[c&H0&+0&D3:7]:1-[c&H0&+0&D3:9](:[c:10]):[c:8]|[CH3:1][C:2]1([CH2:3][O:4][CH:5]([O:6][CH2:7]1)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[C:14](=O)[CH:15]1[C:16]([c:17]2[cH:18][cH:19][cH:20][c:21]([c:22]2[C:23]1=[O:24])[NH:25][C:26](=[O:27])[NH:28][N:29]1[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1)=O)[CH3:35].[NH2:36][NH2:37]>O.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][C:2]1([CH2:3][O:4][CH:5]([O:6][CH2:7]1)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[n:36][nH:37][c:16]2[c:15]1[C:23]([c:22]1[c:21]([cH:20][cH:19][cH:18][c:17]1-2)[NH:25][C:26](=[O:27])[NH:28][N:29]1[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1)=[O:24])[CH3:35]|US08853207B2_0328
4.1.8|[C:12]-[C&H0&+0&D3:11](-[C&H2&+0&D2:10]-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[c:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:9](:[c&H1&+0&D2:10]:1)-[c&H0&+0&D3:8](:[c:7]):[c:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|Cl.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH:9][NH2:10].O=[C:11]([CH2:12][CH2:13][CH2:14][OH:15])[CH2:16][C:17](=O)[c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[Cl:24]>CO.c1ccncc1>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[n:9]1[n:10][c:11]([cH:16][c:17]1-[c:18]1[cH:23][cH:22][c:21]([cH:20][cH:19]1)[Cl:24])[CH2:12][CH2:13][CH2:14][OH:15]|US20170174633A1_0179
4.2.16|[C:12]-[C&H0&+0&D3:11](=[O&H0&+0&D1:10])-[N&H1&+0&D2:9]-[C&H1&+0&D3:8](-[C&H0&+0&D3:7](-[c&H0&+0&D3:6](:[c:5]):[c:4])=O)-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:12]-[c&H0&+0&D3:11]1:[o&H0&+0&D2:10]:[c&H0&+0&D3:7](:[c&H0&+0&D3:8](:[n&H0&+0&D2:9]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:6](:[c:5]):[c:4]|[O:1]=[C:2]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][Br:8])[NH:9][CH:10]([C:11](=O)[c:12]1[cH:13][cH:14][c:15]([cH:16][cH:17]1)[Cl:18])[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25]>Cc1ccccc1.O=P(Cl)(Cl)Cl>[Cl:18][c:15]1[cH:16][cH:17][c:12]([cH:13][cH:14]1)-[c:11]1[o:1][c:2]([n:9][c:10]1-[c:19]1[cH:20][cH:21][c:22]([cH:23][cH:24]1)[Cl:25])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][Br:8]|US20040157891A1_0708
4.1.8|[C:12]-[C&H0&+0&D3:11](-[C&H2&+0&D2:10]-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[o:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:9](:[c&H1&+0&D2:10]:1)-[c&H0&+0&D3:8](:[c:7]):[o:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][NH:2][c:3]1[cH:4][cH:5][cH:6][cH:7][c:8]1[C:9](=[O:10])[OH:11].O=[C:12]([CH2:13][C:14](=O)[C:15]([F:16])([F:17])[F:18])[c:19]1[cH:20][cH:21][cH:22][o:23]1>CC(=O)O.CCOC(C)=O>[O:10]=[C:9]([OH:11])[c:8]1[cH:7][cH:6][cH:5][cH:4][c:3]1-[n:2]1[n:1][c:14]([cH:13][c:12]1-[c:19]1[cH:20][cH:21][cH:22][o:23]1)[C:15]([F:16])([F:17])[F:18]|US20010044445A1_2237
4.1.62|[C:12]-[C&H1&+0&D3:11](-[C&H0&+0&D3:10](-[O&H0&+0&D2:9]-C)=O)-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H2&+0&D1:4]-[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:12]-[c&H0&+0&D3:11]1:[c&H0&+0&D3:10](=[O&H0&+0&D1:9]):[n&H0&+0&D3:2](:[n:1]):[c:3]:[n&H1&+0&D2:4]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|C[O:1][C:2](=O)[CH:3]([C:4](=O)[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1.[NH2:25][C:26](=[O:27])[c:28]1[cH:29][c:30]([nH:31][n:32]1)[NH2:33]>O.Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[NH2:25][C:26](=[O:27])[c:28]1[cH:29][c:30]2[nH:33][c:4]([c:3]([c:2]([n:31]2[n:32]1)=[O:1])[CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)-[c:5]1[cH:10][cH:9][c:8]([cH:7][cH:6]1)[O:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1|US10035801B2_0479
4.1.60|[C:12]-[C&H0&+0&D3:11](=[C&H1&+0&D2:10]-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[c:6])=O)-O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:9](:[c&H1&+0&D2:10]:1)-[c&H0&+0&D3:8](:[c:7]):[c:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[ClH:1].[CH3:2][O:3][C:4](=[O:5])[C:6](O)=[CH:7][C:8](=O)[c:9]1[cH:10][cH:11][cH:12][n:13][cH:14]1.[NH2:15][NH:16][c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[Cl:23])[Cl:24]>CCO>[ClH:1].[CH3:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([n:16]([n:15]1)-[c:17]1[cH:18][cH:19][c:20]([c:21]([cH:22]1)[Cl:23])[Cl:24])-[c:9]1[cH:14][n:13][cH:12][cH:11][cH:10]1|US20070225335A1_0097
4.1.8|[C:12]-[C&H0&+0&D3:11](-[C&H2&+0&D2:10]-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[c:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:9](:[c&H1&+0&D2:10]:1)-[c&H0&+0&D3:8](:[c:7]):[c:6])-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][CH:2]([CH3:3])[C:4](=O)[CH2:5][C:6](=O)[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[F:13].[NH2:14][NH:15][c:16]1[cH:17][n:18][cH:19][cH:20][n:21]1>CC(=O)O>[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][c:6]([n:15]([n:14]1)-[c:16]1[cH:17][n:18][cH:19][cH:20][n:21]1)-[c:7]1[cH:8][cH:9][c:10]([cH:11][cH:12]1)[F:13]|EP1785418A1_0525
4.1.8|[C:12]-[C&H1&+0&D3:11](-[C&H0&+0&D3:10](-[c&H0&+0&D3:9](:[c:8]):[c:7])=O)-[C&H0&+0&D3:6](-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[N&H2&+0&D1:2]-[N&H2&+0&D1:1]>>[C:12]-[c&H0&+0&D3:11]1:[c&H0&+0&D3:10](:[n&H0&+0&D2:2]:[n&H1&+0&D2:1]:[c&H0&+0&D3:6]:1-[c&H0&+0&D3:5](:[c:4]):[c:3])-[c&H0&+0&D3:9](:[c:8]):[c:7]|O.[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][CH:7]([C:8](=O)[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[C:15](=O)[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[NH2:22][NH2:23]>O.CCO.CC(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH2:6][c:7]1[c:15]([n:22][nH:23][c:8]1-[c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)-[c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1|US20050277630A1_0741
2.3.8|[N&H2&+0&D1:11]-[c:10]:[c:9]-[C&H0&+0&D3:8](=[O&H0&D1:7])-[N&H1&+0&D2:6]-[c&H0&+0&D3:5](:[c:4]):[c:3].[O&H0&D1:2]=[C&H0&+0&D3:1](-O-C(-Cl)(-Cl)-Cl)-O-C(-Cl)(-Cl)-Cl>>[n&H1&+0&D2:11]1:[c:10]:[c:9]:[c&H0&+0&D3:8](=[O&H0&D1:7]):[n&H0&+0&D3:6](:[c&H0&+0&D3:1]:1=[O&H0&D1:2])-[c&H0&+0&D3:5](:[c:4]):[c:3]|[CH3:1][S:2][c:3]1[n:4][cH:5][c:6]([c:7]([n:8]1)[NH2:9])[C:10](=[O:11])[NH:12][c:13]1[cH:14][c:15]([cH:16][cH:17][c:18]1[CH3:19])[NH:20][C:21](=[O:22])[c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[C:29]([F:30])([F:31])[F:32].[O:33]=[C:34](OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl>CC(C)N(CC)C(C)C.CCOC(C)=O.C1COCCO1>[CH3:1][S:2][c:3]1[n:4][cH:5][c:6]2[c:7]([n:8]1)[nH:9][c:34]([n:12]([c:10]2=[O:11])-[c:13]1[cH:14][c:15]([cH:16][cH:17][c:18]1[CH3:19])[NH:20][C:21](=[O:22])[c:23]1[cH:24][cH:25][cH:26][c:27]([cH:28]1)[C:29]([F:30])([F:31])[F:32])=[O:33]|US20090062258A1_0635
4.1.48|[C:11]-[C&H0&+0&D3:10](=[C&H1&+0&D2:9]-N(-C)-C)-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H1&+0&D1:4]=[C&H0&+0&D3:3](-[N&H2&+0&D1:2])-[N&H2&D1:1]>>[C:11]-[c&H0&+0&D3:10]1:[c&H1&+0&D2:9]:[n&H0&+0&D2:4]:[c&H0&+0&D3:3](:[n&H0&+0&D2:2]:[c&H0&+0&D3:8]:1-[c&H0&+0&D3:7](:[c:6]):[c:5])-[N&H2&D1:1]|CN(C)[CH:1]=[C:2]1[CH2:3][N:4]=[C:5]([c:6]2[cH:7][c:8]([cH:9][cH:10][c:11]2[C:12]1=O)[Cl:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[NH:20]=[C:21]([NH2:22])[NH2:23].O=C(O)O>[Na+].CO.C[O-].ClCCl>[NH2:22][c:21]1[n:20][cH:1][c:2]2[CH2:3][N:4]=[C:5]([c:6]3[cH:7][c:8]([cH:9][cH:10][c:11]3-[c:12]2[n:23]1)[Cl:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1|US07998952B2_0313
4.1.14|[C:12]-[C&H0&+0&D3:11](-[C&H2&+0&D2:10]-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)=O.[N&H2&+0&D1:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:8](:[c&H1&+0&D2:9]:[c&H1&+0&D2:10]:1)-[c&H0&+0&D3:7](:[c:6]):[c:5])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=O)[CH2:10][CH2:11][C:12](=O)[C:13]([F:14])([F:15])[F:16].[NH2:17][c:18]1[cH:19][cH:20][c:21]([cH:22][cH:23]1)[F:24]>>[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[cH:10][cH:11][c:12]([n:17]1-[c:18]1[cH:23][cH:22][c:21]([cH:20][cH:19]1)[F:24])[C:13]([F:14])([F:15])[F:16]|US20070082912A1_2021
4.1.62|[C:12]-[C&H0&+0&D3:11](-[C&H1&+0&D3:10](-[C&H0&+0&D3:9](-[O&H0&+0&D2:8]-C)=O)-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H2&+0&D1:4]-[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C:12]-[c&H0&+0&D3:11]1:[n&H1&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[n:1]):[c&H0&+0&D3:9](=[O&H0&+0&D1:8]):[c&H0&+0&D3:10]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|C[O:1][C:2](=O)[CH:3]([C:4](=O)[CH2:5][O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[c:14]1[cH:15][cH:16][c:17]2[O:18][CH2:19][CH2:20][O:21][c:22]2[cH:23]1.[NH2:24][c:25]1[nH:26][n:27][c:28]([c:29]1-[c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)-[c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1>[Na+].CC(=O)O.[O-]C(=O)O>[O:1]=[c:2]1[c:3]([c:4]([nH:24][c:25]2[c:29]([c:28]([n:27][n:26]12)-[c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1)-[c:30]1[cH:35][cH:34][cH:33][cH:32][cH:31]1)[CH2:5][O:6][CH2:7][c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)-[c:14]1[cH:15][cH:16][c:17]2[O:18][CH2:19][CH2:20][O:21][c:22]2[cH:23]1|US10800782B2_0935
4.1.61|[C&H3&D1:11]-[C&H0&+0&D3:10](-[C&H1&+0&D3:9](-[C:8])-[C&H0&+0&D3:7](-[O&H0&+0&D2:6]-C-C)=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[n:2]):[n:1]>>[C&H3&D1:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:7](-[O&H1&+0&D1:6]):[c&H0&+0&D3:9]:1-[C:8])-[c&H0&+0&D3:3](:[n:2]):[n:1]|CC[O:1][C:2](=O)[CH:3]([CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[C:11]([CH3:12])=O.[CH3:13][c:14]1[cH:15][cH:16][c:17]2[nH:18][c:19]([n:20][c:21]2[cH:22]1)[NH:23][NH2:24]>O.CC(=O)O.CC#N>[CH3:12][c:11]1[n:24][n:23]([c:2]([c:3]1[CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[OH:1])-[c:19]1[n:20][c:21]2[cH:22][c:14]([cH:15][cH:16][c:17]2[nH:18]1)[CH3:13]|US09212169B2_0406
4.1.8|[C:12]-[C&H0&+0&D3:11](-[C&H2&+0&D2:10]-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[n:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[n:1]>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:9](:[c&H1&+0&D2:10]:1)-[c&H0&+0&D3:8](:[c:7]):[n:6])-[c&H0&+0&D3:3](:[c:2]):[n:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7][C:8](=O)[c:9]1[cH:10][cH:11][cH:12][cH:13][n:14]1.[NH2:15][NH:16][c:17]1[cH:18][cH:19][c:20]([n:21][n:22]1)[Cl:23]>Cl.CCO>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([n:16]([n:15]1)-[c:17]1[cH:18][cH:19][c:20]([n:21][n:22]1)[Cl:23])-[c:9]1[cH:10][cH:11][cH:12][cH:13][n:14]1|US20070219210A1_0725
4.1.8|[C:12]-[C&H0&+0&D3:11](-[C&H2&+0&D2:10]-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[n:7]):[s:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:9](:[c&H1&+0&D2:10]:1)-[c&H0&+0&D3:8](:[n:7]):[s:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[n:7][c:8]([s:9][c:10]2[cH:11]1)[C:12](=O)[CH2:13][C:14](=O)[C:15]([F:16])([F:17])[F:18].[CH3:19][S:20](=[O:21])(=[O:22])[c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[NH:29][NH2:30].Cl>CCO>[CH3:19][S:20](=[O:21])(=[O:22])[c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)-[n:29]1[n:30][c:14]([cH:13][c:12]1-[c:8]1[n:7][c:6]2[cH:5][cH:4][c:3]([cH:11][c:10]2[s:9]1)[O:2][CH3:1])[C:15]([F:16])([F:17])[F:18]|US06136831A
4.1.8|[C:12]-[C&H0&+0&D3:11](-[C&H2&+0&D2:10]-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[n:6])=O)=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:5]:[n&H0&+0&D3:4](:[c&H0&+0&D3:9](:[c&H1&+0&D2:10]:1)-[c&H0&+0&D3:8](:[c:7]):[n:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[C:6](=O)[CH2:7][C:8](=O)[c:9]1[cH:10][c:11]([cH:12][cH:13][n:14]1)[S:15][CH3:16].[CH3:17][O:18][c:19]1[cH:20][cH:21][c:22]([cH:23][n:24]1)[NH:25][NH2:26]>>[CH3:16][S:15][c:11]1[cH:12][cH:13][n:14][c:9]([cH:10]1)-[c:8]1[cH:7][c:6]([n:26][n:25]1-[c:22]1[cH:21][cH:20][c:19]([n:24][cH:23]1)[O:18][CH3:17])[C:4](=[O:5])[O:3][CH2:2][CH3:1]|EP1762568A1_0126
4.3.3|[C:12]-[C&H1&+0&D3:11](-[C&H0&+0&D3:10](-[c&H0&+0&D3:9](:[c:8]):[c:7])=O)-Br.[N&H2&+0&D1:6]-[C&H0&+0&D3:5](=[S&H0&+0&D1:4])-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:12]-[c&H0&+0&D3:11]1:[s&H0&+0&D2:4]:[c&H0&+0&D3:5](:[n&H0&+0&D2:6]:[c&H0&+0&D3:10]:1-[c&H0&+0&D3:9](:[c:8]):[c:7])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[NH2:1][C:2](=[S:3])[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[OH:10].[O:11]=[C:12]([OH:13])[CH2:14][CH:15](Br)[C:16](=O)[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23]>CN(C)C=O>[O:11]=[C:12]([OH:13])[CH2:14][c:15]1[s:3][c:2]([n:1][c:16]1-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[Cl:23])-[c:4]1[cH:5][cH:6][c:7]([cH:8][cH:9]1)[OH:10]|US20050288273A1_1289
4.1.48|[C&H3&D1:11]-[C&H0&+0&D3:10](=[N&H1&+0&D1:9])-[N&H2&+0&D1:8].[C:7]-[C&H0&+0&D3:6](=[C&H1&+0&D2:5]-N(-C)-C)-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O>>[C&H3&D1:11]-[c&H0&+0&D3:10]1:[n&H0&+0&D2:9]:[c&H1&+0&D2:5]:[c&H0&+0&D3:6](-[C:7]):[c&H0&+0&D3:4](:[n&H0&+0&D2:8]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1]|Cl.[CH3:1][C:2](=[NH:3])[NH2:4].CN(C)[CH:5]=[C:6]1[CH2:7][N:8]=[C:9]([c:10]2[cH:11][c:12]([cH:13][cH:14][c:15]2[C:16]1=O)[Cl:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>[Na+].C[O-].CO.ClCCl>[CH3:1][c:2]1[n:3][cH:5][c:6]2[CH2:7][N:8]=[C:9]([c:10]3[cH:11][c:12]([cH:13][cH:14][c:15]3-[c:16]2[n:4]1)[Cl:17])[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US20110212968A1_1515
4.3.3|[N&H2&+0&D1:12]-[C&H0&+0&D3:11](-[N:10])=[S&H0&+0&D1:9].[c:8]:[c&H0&+0&D3:7](:[c:6])-[C&H0&+0&D3:5](-[C&H1&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Br)=O>>[n&H0&+0&D2:12]1:[c&H0&+0&D3:11](-[N:10]):[s&H0&+0&D2:9]:[c&H0&+0&D3:4](:[c&H0&+0&D3:5]:1-[c&H0&+0&D3:7](:[c:8]):[c:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|Br.[CH3:1][NH:2][C:3]([NH2:4])=[S:5].[CH3:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[C:14](=O)[CH:15](Br)[c:16]1[cH:17][n:18][cH:19][cH:20][cH:21]1>CCN(CC)CC.CC#N>[CH3:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[n:4][c:3]([s:5][c:15]1-[c:16]1[cH:21][cH:20][cH:19][n:18][cH:17]1)[NH:2][CH3:1]|US20090253687A1_1124
4.3.3|[C:12]-[C&H0&+0&D3:11](-[N&H2&+0&D1:10])=[S&H0&+0&D1:9].[c:8]:[c&H0&+0&D3:7](:[c:6])-[C&H0&+0&D3:5](-[C&H1&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Br)=O>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:10]:[c&H0&+0&D3:5](:[c&H0&+0&D3:4](:[s&H0&+0&D2:9]:1)-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:7](:[c:8]):[c:6]|[CH3:1][CH2:2][C:3]([NH2:4])=[S:5].[CH3:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[C:14](=O)[CH:15](Br)[c:16]1[cH:17][n:18][cH:19][cH:20][cH:21]1>CCN(CC)CC.CC#N>[CH3:6][O:7][c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)-[c:14]1[n:4][c:3]([s:5][c:15]1-[c:16]1[cH:21][cH:20][cH:19][n:18][cH:17]1)[CH2:2][CH3:1]|US20070203155A1_0289
3.11.81|[C&H3&D1:11]-[#14&H0&+0&D4:10](-[C&H3&D1:9])(-[C&H3&D1:8])-[C&H0&+0&D4:7](-[F&H0&D1:6])(-[F&H0&D1:5])-[F&H0&D1:4].[C:3]-[C&H1&+0&D2:2]=[O&H0&+0&D1:1]>>[C&H3&D1:11]-[#14&H0&+0&D4:10](-[C&H3&D1:9])(-[C&H3&D1:8])-[O&H0&+0&D2:1]-[C&H1&+0&D3:2](-[C:3])-[C&H0&+0&D4:7](-[F&H0&D1:6])(-[F&H0&D1:5])-[F&H0&D1:4]|[O:1]=[CH:2][CH:3]1[CH2:4][CH2:5][C:6]2([CH2:7][CH2:8]1)[O:9][CH2:10][CH2:11][O:12]2.[CH3:13][Si:14]([CH3:15])([CH3:16])[C:17]([F:18])([F:19])[F:20]>CCCC[N+](CCCC)(CCCC)CCCC.[F-]>[CH3:13][Si:14]([CH3:15])([CH3:16])[O:1][CH:2]([CH:3]1[CH2:4][CH2:5][C:6]2([CH2:7][CH2:8]1)[O:9][CH2:10][CH2:11][O:12]2)[C:17]([F:18])([F:19])[F:20]|US10214546B2_0635
1.3.7|[O&H0&D1:12]=[C&H0&+0&D3:11](-[N&H1&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[c:7])-[N&H1&+0&D2:6]-[C&H0&+0&D3:5](=[O&H0&D1:4])-[c:3]:[c&H0&+0&D3:2](:[n:1])-Cl>>[O&H0&D1:12]=[c&H0&+0&D3:11]1:[n&H0&+0&D3:10](:[c&H0&+0&D3:2](:[n:1]):[c:3]:[c&H0&+0&D3:5](=[O&H0&D1:4]):[n&H1&+0&D2:6]:1)-[c&H0&+0&D3:9](:[c:8]):[c:7]|[CH3:1][c:2]1[cH:3][cH:4][cH:5][c:6]([c:7]1[NH:8][C:9](=[O:10])[NH:11][C:12](=[O:13])[c:14]1[cH:15][c:16]([c:17]([n:18][c:19]1Cl)[Cl:20])[Cl:21])[CH:22]([CH3:23])[CH3:24]>C[Si](C)(C)[N-][Si](C)(C)C.C1CCOC1.[K+]>[CH3:23][CH:22]([CH3:24])[c:6]1[cH:5][cH:4][cH:3][c:2]([c:7]1-[n:8]1[c:19]2[n:18][c:17]([c:16]([cH:15][c:14]2[c:12]([nH:11][c:9]1=[O:10])=[O:13])[Cl:21])[Cl:20])[CH3:1]|US20190374542A1_0962
4.1.62|[N&H2&+0&D1:13]-[c:12]:[c:11]-[C&H0&+0&D3:10](=[O&H0&D1:9])-[N&H1&+0&D2:8]-[c&H0&+0&D3:7](:[c:6]):[c:5].[c:4]:[c&H0&+0&D3:3](:[c:2])-[C&H1&+0&D2:1]=O>>[n&H0&+0&D2:13]1:[c&H0&+0&D3:1](:[n&H0&+0&D3:8](:[c&H0&+0&D3:10](=[O&H0&D1:9]):[c:11]:[c:12]:1)-[c&H0&+0&D3:7](:[c:6]):[c:5])-[c&H0&+0&D3:3](:[c:4]):[c:2]|[CH3:1][CH2:2][CH:3]([CH3:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)[NH:11][C:12](=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][c:19]1[NH2:20].[CH3:21][c:22]1[cH:23][c:24]([cH:25][c:26]([c:27]1[O:28][CH2:29][CH2:30][OH:31])[CH3:32])[CH:33]=O>[Na+].Cc1ccc(cc1)S(=O)(=O)O.CC(=O)N(C)C.[O-]S(=O)O>[CH3:1][CH2:2][CH:3]([CH3:4])[c:5]1[cH:6][cH:7][c:8]([cH:9][cH:10]1)-[n:11]1[c:12]([c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]2[n:20][c:33]1-[c:24]1[cH:25][c:26]([c:27]([c:22]([cH:23]1)[CH3:21])[O:28][CH2:29][CH2:30][OH:31])[CH3:32])=[O:13]|US08952021B2_0397
4.1.75|[N&H2&+0&D1:13]-[N&H1&+0&D2:12]-[c&H0&+0&D3:11](:[c:10]):[c:9].[O&H0&D1:8]=[C&H0&+0&D3:7](-[c:6]:[c:5]-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])=O)-O>>[n&H0&+0&D2:13]1:[n&H0&+0&D3:12](:[c&H0&+0&D3:7](=[O&H0&D1:8]):[c:6]:[c:5]:[c&H0&+0&D3:4]:1-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:11](:[c:10]):[c:9]|[NH2:1][NH:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1.O=[C:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[c:16]1[n:17][cH:18][cH:19][cH:20][c:21]1[C:22](=[O:23])O>CCOCC.Cc1ccccc1>[O:23]=[c:22]1[c:21]2[cH:20][cH:19][cH:18][n:17][c:16]2[c:9]([n:1][n:2]1-[c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1)-[c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1|US05716954A
4.1.85|[N&H2&+0&D1:13]-[n&H0&+&D3:12](:[c:11]):[c&H1&+0&D2:10]:[c:9].[c:8]:[c&H0&+0&D3:7](:[n:6])-[C&H0&+0&D2:5]#[C&H0&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[n&H0&+0&D2:13]1:[c&H0&+0&D3:4](:[c&H0&+0&D3:5](:[c&H0&+0&D3:10](:[c:9]):[n&H0&+0&D3:12]:1:[c:11])-[c&H0&+0&D3:7](:[c:8]):[n:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[I-].[NH2:1][n+:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[O:8]=[S:9](=[O:10])([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:18][cH:19][c:20]([n:21][n:22]1)[C:23]#[C:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1>O.[Cl-].Cl.C[N+](C)(C)Cc1ccccc1.O[Na].ClCCl>[O:8]=[S:9](=[O:10])([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[c:17]1[cH:18][cH:19][c:20]([n:21][n:22]1)-[c:23]1[c:24]([n:1][n:2]2[cH:7][cH:6][cH:5][cH:4][c:3]12)-[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1|US20040110763A1_0409
4.1.62|[C&H3&D1:12]-[C&H0&+0&D3:11](-[C&H1&+0&D3:10](-[C&H0&+0&D3:9](-[O&H0&+0&D2:8]-C)=O)-[c&H0&+0&D3:7](:[c:6]):[c:5])=O.[N&H2&+0&D1:4]-[c:3]:[n&H1&+0&D2:2]:[n:1]>>[C&H3&D1:12]-[c&H0&+0&D3:11]1:[n&H1&+0&D2:4]:[c:3]:[n&H0&+0&D3:2](:[n:1]):[c&H0&+0&D3:9](=[O&H0&+0&D1:8]):[c&H0&+0&D3:10]:1-[c&H0&+0&D3:7](:[c:6]):[c:5]|[CH3:1][C:2](=O)[CH:3]([C:4](=O)[O:5]C)[c:6]1[cH:7][cH:8][c:9]2[n:10][cH:11][cH:12][cH:13][c:14]2[cH:15]1.[NH2:16][c:17]1[nH:18][n:19][c:20]([c:21]1-[c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)-[c:28]1[cH:29][cH:30][cH:31][cH:32][c:33]1[F:34]>[Na+].CC(=O)O.[O-]C(=O)O>[CH3:1][c:2]1[nH:16][c:17]2[c:21]([c:20]([n:19][n:18]2[c:4]([c:3]1-[c:6]1[cH:7][cH:8][c:9]2[n:10][cH:11][cH:12][cH:13][c:14]2[cH:15]1)=[O:5])-[c:28]1[cH:29][cH:30][cH:31][cH:32][c:33]1[F:34])-[c:22]1[cH:27][cH:26][cH:25][cH:24][cH:23]1|US10329298B2_1770
4.1.14|[C&H3&D1:12]-[C&H0&+0&D3:11](-[C&H2&+0&D2:10]-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)=O.[N&H2&+0&D1:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:8](:[c&H1&+0&D2:9]:[c&H1&+0&D2:10]:1)-[c&H0&+0&D3:7](:[c:6]):[c:5])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][C:2](=O)[CH2:3][CH2:4][C:5](=O)[c:6]1[cH:7][cH:8][c:9]([cH:10][cH:11]1)[S:12]([CH3:13])(=[O:14])=[O:15].[NH2:16][c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23]>Cc1ccccc1.Cc1ccc(cc1)S(=O)(=O)O>[CH3:13][S:12](=[O:14])(=[O:15])[c:9]1[cH:10][cH:11][c:6]([cH:7][cH:8]1)-[c:5]1[cH:4][cH:3][c:2]([n:16]1-[c:17]1[cH:18][cH:19][c:20]([cH:21][cH:22]1)[F:23])[CH3:1]|US20070082912A1_2302
4.3.3|[N&H2&+0&D1:12]-[C&H0&+0&D3:11](-[N&H2&D1:10])=[S&H0&+0&D1:9].[c:8]:[c&H0&+0&D3:7](:[c:6])-[C&H0&+0&D3:5](-[C&H1&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[c:1])-Br)=O>>[n&H0&+0&D2:12]1:[c&H0&+0&D3:11](-[N&H2&D1:10]):[s&H0&+0&D2:9]:[c&H0&+0&D3:4](:[c&H0&+0&D3:5]:1-[c&H0&+0&D3:7](:[c:8]):[c:6])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[C:9](=O)[CH:10](Br)[c:11]1[cH:12][n:13][cH:14][cH:15][cH:16]1.[NH2:17][C:18]([NH2:19])=[S:20].Br>CCN(CC)CC.CC#N>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[c:9]1[n:19][c:18]([s:20][c:10]1-[c:11]1[cH:16][cH:15][cH:14][n:13][cH:12]1)[NH2:17]|US20200172531A1_0438
4.1.14|[C:13]-[C&H1&+0&D3:12](-[C&H2&+0&D2:11]-[C&H0&+0&D3:10](-[c&H0&+0&D3:9](:[c:8]):[c:7])=O)-[C&H0&+0&D3:6](-[C:5])=O.[N&H2&+0&D1:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:13]-[c&H0&+0&D3:12]1:[c&H1&+0&D2:11]:[c&H0&+0&D3:10](:[n&H0&+0&D3:4](:[c&H0&+0&D3:6]:1-[C:5])-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:9](:[c:8]):[c:7]|[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)[NH2:9].O=[C:10]([CH2:11][CH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][C:17]1=O)[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>CC(=O)O.CC(C)O>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([cH:7][cH:8]1)-[n:9]1[c:17]2[CH2:16][CH2:15][CH2:14][CH2:13][c:12]2[cH:11][c:10]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1|US08288432B2_0343
4.1.8|[C:13]-[C&H1&+0&D3:12](-[C&H0&+0&D3:11](-[c&H0&+0&D3:10](:[c:9]):[c:8])=O)-[C&H0&+0&D3:7](-[C:6])=O.[N&H2&+0&D1:5]-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:13]-[c&H0&+0&D3:12]1:[c&H0&+0&D3:11](:[n&H0&+0&D3:4](:[n&H0&+0&D2:5]:[c&H0&+0&D3:7]:1-[C:6])-[c&H0&+0&D3:3](:[c:2]):[c:1])-[c&H0&+0&D3:10](:[c:9]):[c:8]|O=[C:1]([CH:2]1[CH2:3][CH2:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]2[C:11]1=O)[C:12]([F:13])([F:14])[F:15].[NH2:16][S:17](=[O:18])(=[O:19])[c:20]1[cH:21][cH:22][c:23]([cH:24][cH:25]1)[NH:26][NH2:27].Cl>CCO>[NH2:16][S:17](=[O:18])(=[O:19])[c:20]1[cH:25][cH:24][c:23]([cH:22][cH:21]1)-[n:26]1[n:27][c:1]([c:2]2[CH2:3][CH2:4][c:5]3[cH:6][cH:7][cH:8][cH:9][c:10]3-[c:11]21)[C:12]([F:13])([F:14])[F:15]|EP2499146B1_0364
4.1.14|[C:13]-[C&H0&+0&D3:12](-[C&H2&+0&D2:11]-[C&H1&+0&D3:10](-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[c:6])=O)-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C:13]-[c&H0&+0&D3:12]1:[n&H0&+0&D3:1](-[C:2]):[c&H0&+0&D3:9](:[c&H0&+0&D3:10](:[c&H1&+0&D2:11]:1)-[c&H0&+0&D3:5](:[c:4]):[c:3])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][CH:2]([CH3:3])[C:4](=O)[CH2:5][CH:6]([C:7](=O)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[F:14])[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21].[CH3:22][C:23]([CH3:24])([CH3:25])[O:26][C:27](=[O:28])[CH2:29][C@H:30]1[CH2:31][C@H:32]([O:33][C:34]([O:35]1)([CH3:36])[CH3:37])[CH2:38][CH2:39][NH2:40]>>[CH3:1][CH:2]([CH3:3])[c:4]1[cH:5][c:6]([c:7]([n:40]1[CH2:39][CH2:38][C@@H:32]1[CH2:31][C@@H:30]([O:35][C:34]([O:33]1)([CH3:36])[CH3:37])[CH2:29][C:27](=[O:28])[O:26][C:23]([CH3:22])([CH3:24])[CH3:25])-[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[F:14])-[c:15]1[cH:16][cH:17][c:18]([cH:19][cH:20]1)[F:21]|US08178697B2_0145
3.11.82|[C&H3&D1:12]-[#14&H0&+0&D4:11](-[C&H3&D1:10])(-[C&H3&D1:9])-[C&H0&+0&D4:8](-[F&H0&D1:7])(-[F&H0&D1:6])-[F&H0&D1:5].[C:4]-[C&H0&+0&D3:3](-[C:2])=[O&H0&+0&D1:1]>>[C&H3&D1:12]-[#14&H0&+0&D4:11](-[C&H3&D1:10])(-[C&H3&D1:9])-[O&H0&+0&D2:1]-[C&H0&+0&D4:3](-[C:4])(-[C:2])-[C&H0&+0&D4:8](-[F&H0&D1:7])(-[F&H0&D1:6])-[F&H0&D1:5]|[CH3:1][CH2:2][CH2:3][CH:4]1[CH2:5][CH2:6][CH:7]([CH2:8][CH2:9]1)[CH:10]1[CH2:11][CH2:12][CH:13]2[CH2:14][C:15]([CH2:16][CH2:17][CH:18]2[CH2:19]1)=[O:20].[CH3:21][Si:22]([CH3:23])([CH3:24])[C:25]([F:26])([F:27])[F:28]>>[CH3:1][CH2:2][CH2:3][CH:4]1[CH2:5][CH2:6][CH:7]([CH2:8][CH2:9]1)[CH:10]1[CH2:11][CH2:12][CH:13]2[CH2:14][C:15]([CH2:16][CH2:17][CH:18]2[CH2:19]1)([O:20][Si:22]([CH3:21])([CH3:23])[CH3:24])[C:25]([F:26])([F:27])[F:28]|US07375098B2_0319
4.1.61|[N&H2&+0&D1:12]-[N&H1&+0&D2:11]-[c&H0&+0&D3:10](:[c:9]):[n:8].[O&H0&D1:7]=[C&H0&+0&D3:6](-[C&H0&+0&D3:5](=[C&H1&+0&D2:4]-N(-C)-C)-[n&H0&+0&D3:3](:[c:2]):[n:1])-O-C-C>>[n&H1&+0&D2:12]1:[c&H1&+0&D2:4]:[c&H0&+0&D3:5](:[c&H0&+0&D3:6](=[O&H0&D1:7]):[n&H0&+0&D3:11]:1-[c&H0&+0&D3:10](:[c:9]):[n:8])-[n&H0&+0&D3:3](:[c:2]):[n:1]|CCO[C:1](=[O:2])[C:3](=[CH:4]N(C)C)[n:5]1[cH:6][cH:7][n:8][n:9]1.[NH2:10][NH:11][c:12]1[cH:13][c:14]([n:15][cH:16][n:17]1)[Cl:18].[ClH:19]>O=C(O)C(F)(F)F.C1COCCO1.CCO>[O:2]=[c:1]1[c:3]([cH:4][nH:10][n:11]1-[c:12]1[cH:13][c:14]([n:15][cH:16][n:17]1)[Cl:18])-[n:5]1[cH:6][cH:7][n:8][n:9]1.[ClH:19]|US08389520B2_0693
2.3.10|[C:12]-[C&H0&+0&D3:11](=[N&H0&+0&D2:10]-[N&H1&+0&D2:9]-[c&H0&+0&D3:8](:[c:7]):[c:6])-[C&H0&+0&D3:5](=[O&H0&D1:4])-[N&H1&+0&D2:3]-[C&H0&+0&D3:2](=[O&H0&D1:1])-O-C-C>>[C:12]-[c&H0&+0&D3:11]1:[n&H0&+0&D2:10]:[n&H0&+0&D3:9](:[c&H0&+0&D3:2](=[O&H0&D1:1]):[n&H1&+0&D2:3]:[c&H0&+0&D3:5]:1=[O&H0&D1:4])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][C:2]([C:3]#[N:4])([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:12][cH:13][c:14]([cH:15][cH:16]1)[NH:17][N:18]=[C:19]([C:20]#[N:21])[C:22](=[O:23])[NH:24][C:25](=[O:26])OCC>CC([O-])=O.CC(=O)O.[K+]>[CH3:1][C:2]([C:3]#[N:4])([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[c:11]1[cH:16][cH:15][c:14]([cH:13][cH:12]1)-[n:17]1[n:18][c:19]([c:22]([nH:24][c:25]1=[O:26])=[O:23])[C:20]#[N:21]|US20200354345A1_0650
4.1.14|[C&H3&D1:13]-[C&H0&+0&D3:12](-[C&H1&+0&D3:11](-[C:10])-[C&H2&+0&D2:9]-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)=O.[N&H2&+0&D1:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:13]-[c&H0&+0&D3:12]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:8](:[c&H1&+0&D2:9]:[c&H0&+0&D3:11]:1-[C:10])-[c&H0&+0&D3:7](:[c:6]):[c:5])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][O:2][C:3](=[O:4])[CH:5]([CH2:6][C:7](=O)[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[S:14]([CH3:15])(=[O:16])=[O:17])[C:18]([CH3:19])=O.[NH2:20][c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[F:27]>CC(=O)O>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]([n:20]([c:18]1[CH3:19])-[c:21]1[cH:22][cH:23][c:24]([cH:25][cH:26]1)[F:27])-[c:8]1[cH:9][cH:10][c:11]([cH:12][cH:13]1)[S:14]([CH3:15])(=[O:16])=[O:17]|US20130310419A1_0309
4.1.14|[C&H3&D1:13]-[C&H0&+0&D3:12](-[C&H2&+0&D2:11]-[C&H1&+0&D3:10](-[C:9])-[C&H0&+0&D3:8](-[c&H0&+0&D3:7](:[c:6]):[c:5])=O)=O.[N&H2&+0&D1:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C&H3&D1:13]-[c&H0&+0&D3:12]1:[n&H0&+0&D3:4](:[c&H0&+0&D3:8](:[c&H0&+0&D3:10](-[C:9]):[c&H1&+0&D2:11]:1)-[c&H0&+0&D3:7](:[c:6]):[c:5])-[c&H0&+0&D3:3](:[c:2]):[c:1]|[CH3:1][CH2:2][O:3][C:4](=[O:5])[CH:6]([CH2:7][C:8]([CH3:9])=O)[C:10](=O)[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1.[NH2:17][c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[Cl:24]>CCO.Cc1ccc(cc1)S(=O)(=O)O>[CH3:1][CH2:2][O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]([n:17]([c:10]1-[c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)-[c:18]1[cH:19][cH:20][cH:21][c:22]([cH:23]1)[Cl:24])[CH3:9]|US20100121048A1_1882
4.1.14|[C:14]-[C&H0&+0&D3:13](-[C&H1&+0&D3:12](-[C:11])-[C&H1&+0&D3:10](-[C&H0&+0&D3:9](-[c&H0&+0&D3:8](:[c:7]):[c:6])=O)-[c&H0&+0&D3:5](:[c:4]):[c:3])=O.[C:2]-[N&H2&+0&D1:1]>>[C:14]-[c&H0&+0&D3:13]1:[n&H0&+0&D3:1](-[C:2]):[c&H0&+0&D3:9](:[c&H0&+0&D3:10](:[c&H0&+0&D3:12]:1-[C:11])-[c&H0&+0&D3:5](:[c:4]):[c:3])-[c&H0&+0&D3:8](:[c:7]):[c:6]|[CH3:1][CH2:2][O:3][CH:4]([CH2:5][CH2:6][NH2:7])[O:8][CH2:9][CH3:10].[CH3:11][CH:12]([CH3:13])[C:14](=O)[CH:15]([C:16](=[O:17])[NH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[CH:25]([C:26](=O)[c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)[F:33])[c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1>Cc1ccccc1.CC(C)(C)C(=O)O>[CH3:11][CH:12]([CH3:13])[c:14]1[c:15]([c:25]([c:26]([n:7]1[CH2:6][CH2:5][CH:4]([O:3][CH2:2][CH3:1])[O:8][CH2:9][CH3:10])-[c:27]1[cH:28][cH:29][c:30]([cH:31][cH:32]1)[F:33])-[c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)[C:16](=[O:17])[NH:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1|US20100260851A1_0158
2.1.10|[C:13]-[C&H0&+0&D3:12](-[C&H0&+0&D3:11](=[O&H0&D1:10])-O-C-C)=[C&H0&+0&D3:9](-[C:8])-[N&H1&+0&D2:7]-[C&H0&+0&D3:6](=[O&H0&D1:5])-[N&H1&+0&D2:4]-[c&H0&+0&D3:3](:[c:2]):[c:1]>>[C:13]-[c&H0&+0&D3:12]1:[c&H0&+0&D3:11](=[O&H0&D1:10]):[n&H0&+0&D3:4](:[c&H0&+0&D3:6](=[O&H0&D1:5]):[n&H1&+0&D2:7]:[c&H0&+0&D3:9]:1-[C:8])-[c&H0&+0&D3:3](:[c:2]):[c:1]|CCO[C:1](=[O:2])[C:3]1[CH2:4][CH2:5][CH2:6][C:7]=1[NH:8][C:9](=[O:10])[NH:11][c:12]1[cH:13][cH:14][c:15]([c:16]([cH:17]1)[C:18](=[O:19])[O:20][CH2:21][CH3:22])[Cl:23]>COCCOC.CC(=O)O.[NaH]>[CH3:22][CH2:21][O:20][C:18](=[O:19])[c:16]1[cH:17][c:12]([cH:13][cH:14][c:15]1[Cl:23])-[n:11]1[c:1]([c:3]2[CH2:4][CH2:5][CH2:6][c:7]2[nH:8][c:9]1=[O:10])=[O:2]|US04859229A
3.11.34|[C:14]-[N&H0&+0&D3:13](-[C&H0&+0&D3:12](=[O&H0&D1:11])-[C&H2&+0&D2:10]-[c&H0&+0&D3:9](:[c:8]):[c:7])-[N&H0&+0&D3:6](-[C:5])-[C&H0&+0&D3:4](-[c&H0&+0&D3:3](:[c:2]):[n:1])=O>>[C:14]-[n&H0&+0&D3:13]1:[c&H0&+0&D3:12](=[O&H0&D1:11]):[c&H0&+0&D3:10](:[c&H0&+0&D3:4](:[n&H0&+0&D3:6]:1-[C:5])-[c&H0&+0&D3:3](:[c:2]):[n:1])-[c&H0&+0&D3:9](:[c:8]):[c:7]|O=[C:1]([c:2]1[cH:3][cH:4][n:5][c:6]([n:7]1)[O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[N:15]1[CH2:16][C:17]2([CH2:18][N:19]1[C:20](=[O:21])[CH2:22][c:23]1[cH:24][cH:25][c:26]([cH:27][cH:28]1)[F:29])[O:30][CH2:31][CH2:32][O:33]2>>[O:21]=[c:20]1[c:22]([c:1]([n:15]2[CH2:16][C:17]3([CH2:18][n:19]12)[O:30][CH2:31][CH2:32][O:33]3)-[c:2]1[cH:3][cH:4][n:5][c:6]([n:7]1)[O:8][c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)-[c:23]1[cH:28][cH:27][c:26]([cH:25][cH:24]1)[F:29]|US06730668B2
