1. Begin with a tetrahydropyran-type ring (a six-membered, fully saturated ring containing five carbons and one oxygen). Number the ring so that the oxygen is at position 1. This ring features a chiral carbon at position 3 (C3), which is R-configured.
2. At C3, attach a nitrogen that is double-bonded to a carbon (forming an imine). This imine carbon bears a hydroxyl group (-OH) and is further bonded to another chiral carbon.
3. This second chiral carbon, which has an S configuration, is part of a piperidine ring (a six-membered, fully saturated ring containing one nitrogen and five carbons). Number the piperidine so that its nitrogen is at position 1; the imine carbon connects at position 3 of this ring.
4. The nitrogen in the piperidine is substituted by a sulfonyl group (-S(=O)2-), which in turn is attached to a carbon (C#) that is part of a five-membered aromatic ring, a pyrazole. In the pyrazole, two nitrogen atoms (one of which is an NH) are located meta to C#, and the remaining two ring carbons each bear a methyl group, resulting in a 3,5-dimethyl-1H-pyrazole.