The issue focused on reproduction issues from biology and physiology and biology related topics such as thyroid imbalance and menstrual hygiene as well as prostate cancer (probably considering fertility drugs). Sex hormones may influence fertility problems such as ovarian dysfunction or ovarian follicles dysfunction (perhaps hormone imbalance causes infertility?) Women should note that fertility medications such as estrogen may interfere with thyroid hormones such as leptin or IGF-1 or stimulate puberty which might interfere with estrogen synthesis (either hormone imbalance will interfere with puberty or puberty suppression may interfere with puberty suppression). Treatment options