The issue focused on drug therapy for schizophrenia and specifically whether subjects should be prescribed antipsychotics when there are serious risks associated with these medications. Here we describe an experimental model that extends previous animal studies by modeling both adverse effects and tolerance of antipsychotics in rats. Because animal models can provide insight into possible mechanisms underlying biological interactions between agents, their analysis may provide insight into potential interactions between antipsychotics and other medications. Animal models also provide insight into potential adverse effects and tolerance in humans. Therefore, although animal models