The issue focused on scientific literature published between 1975 and 1998 that investigated genetic variants linked to schizophrenia. Scientists sought to identify genes associated with psychosis through genome-wide association studies (GWAS), which compare genomes across populations and search for associations among biological markers. GWAS generally discover genetic variants linked to diseases such as autism or bipolar disorder. However, scientists often focus their analysis on biological markers rather than determining cause and effect in genetics research. To avoid biases caused by studying biological markers alone, researchers usually determine whether genetic markers explained