{"knowledge_schema": {"broad_category": "Biochemistry \u2192 Protein Structure and Function \u2192 Disulfide Bridges", "refinement": "This problem focuses on the structural aspects of proteins, specifically the formation of disulfide bridges that are crucial for the protein's therapeutic activity.", "specific_scope": "The task involves analyzing the mass-to-charge (m/z) ratios of peptide fragments resulting from trypsin digestion of a protein with specific disulfide bonds.", "goal": "Identify the m/z values that indicate the presence of the active form of the protein, which has formed the necessary disulfide bridges."}, "summary": "This problem relates to biochemistry, particularly the structural integrity of proteins and their therapeutic functions. The focus is on the formation of disulfide bridges, which are essential for the activity of protein YER33. After trypsin digestion and analysis via LC/MS, the goal is to determine which m/z values correspond to the active form of the protein, indicating successful disulfide bond formation. The correct answer, 935.441, suggests that this value is associated with the peptide fragments that confirm the presence of the active therapeutic protein."}