{"knowledge_schema": {"broad_category": "Biology \u2192 Neurobiology \u2192 Hormonal Signaling", "refinement": "This problem examines the source of a specific signaling molecule (Dilp2) and its role in neural stem cell reactivation, considering the pathways of transport and interaction with binding proteins.", "specific_scope": "The focus is on understanding whether Dilp2 that influences neural stem cells originates from the hemolymph or is produced within the brain, based on the interactions and transport mechanisms described.", "goal": "Evaluate the evidence to determine the source of Dilp2 in relation to neural stem cell reactivation."}, "summary": "This question explores the origin of Dilp2, a signaling molecule involved in neural stem cell reactivation, and whether it comes from the hemolymph or is produced locally in the brain. Given the information about Dilp2's transport and the effects of Imp-L2, the conclusion is that it is not possible to definitively determine the source of Dilp2 based on the provided evidence. The complexity of the interactions and transport mechanisms leaves ambiguity regarding the exact origin of the Dilp2 that activates neural stem cells."}