{"knowledge_schema": {"broad_category": "Biology \u2192 Neuroscience \u2192 Stem Cell Research", "refinement": "This problem focuses on the role of specific genes and proteins in the activation and proliferation of neural stem cells (NCS) in response to various conditions, including glucose availability and genetic manipulation.", "specific_scope": "The context involves experiments with neural stem cells from aged and young mice, examining the effects of sgRNAs targeting specific genes on cell proliferation and differentiation.", "goal": "To determine the impact of specific gene targeting and glucose conditions on the activation of quiescent neural stem cells."}, "summary": "The problem involves analyzing experimental data to assess the role of specific genes in the activation of quiescent neural stem cells (qNCS) in both young and aged mice. The data indicates that targeting the GLUT-4 gene with sgRNA8 enhances the proliferation of qNCS in aged mice, while glucose starvation does not induce activation in either age group. The goal is to evaluate the provided statements based on the experimental results to identify which, if any, are correct regarding the activation of qNCS."}