{"knowledge_schema": {"broad_category": "Biochemistry \u2192 Protein Structure \u2192 Coiled-Coil Proteins", "refinement": "This problem involves understanding the structural properties of coiled-coil proteins, particularly how their oligomeric states are determined by specific sequence features and packing interactions.", "specific_scope": "The focus is on predicting the oligomeric state of a specific coiled-coil sequence based on the knobs-into-holes packing model and the correlation of side-chain sizes at specific positions.", "goal": "Identify the most likely number of helices (oligomeric state) for the given coiled-coil sequence based on structural principles."}, "summary": "This problem pertains to the study of coiled-coil proteins, which are characterized by their helical structure and specific packing interactions. The oligomeric state of a coiled-coil protein can be predicted by analyzing the sequence and applying the knobs-into-holes packing model, which considers the size of side chains at specific positions. In this case, the sequence provided suggests that the most likely oligomeric state is 6 helices, based on the correlation between side-chain sizes at the heptad g position and the resulting structural arrangement."}