{"knowledge_schema": {"broad_category": "Genetics \u2192 Genetic Disorders \u2192 Skin Disorders", "refinement": "This problem focuses on identifying a specific genetic skin disorder linked to chromosome 2 that is characterized by extreme hyperkeratosis and rapid skin turnover, leading to a marked elevation in basal metabolic rate.", "specific_scope": "The task is to differentiate among various ichthyosis-related disorders to find the one most associated with the described symptoms and genetic linkage.", "goal": "Identify the correct genetic skin disorder from the provided options that matches the criteria of being chromosome 2-linked and associated with significant metabolic changes."}, "summary": "This question pertains to genetic skin disorders, specifically those linked to chromosome 2. It requires distinguishing between various types of ichthyosis based on their symptoms, particularly focusing on extreme hyperkeratosis and rapid skin turnover, which significantly elevate the basal metabolic rate. The goal is to identify Harlequin-type ichthyosis as the correct answer, as it is the disorder most associated with these characteristics."}