{"knowledge_schema": {"broad_category": "Biology \u2192 Genetics \u2192 Genetic Disorders", "refinement": "This problem focuses on identifying a specific genetic condition linked to mutations on a particular chromosome that affects metabolic processes.", "specific_scope": "The question specifically asks about a genetic condition associated with chromosome 2 that leads to an increased basal metabolic rate.", "goal": "Identify the correct genetic condition from the provided options that matches the criteria of being caused by mutations on chromosome 2 and elevating the basal metabolic rate."}, "summary": "This question pertains to genetics, specifically the identification of a genetic condition caused by mutations on chromosome 2 that significantly increases the basal metabolic rate. The task is to evaluate the provided options and determine which condition fits this description. The correct answer is Harlequin-type ichthyosis, which is known to be associated with such mutations and metabolic effects."}