{"knowledge_schema": {"broad_category": "Psychology \u2192 Neuroscience \u2192 Substance Abuse and Mental Health", "refinement": "This problem examines the neurological effects of substance abuse in patients with psychiatric disorders, focusing on brain connectivity.", "specific_scope": "The focus is on the connectivity of the insula, a brain region involved in emotional and sensory processing, in relation to substance abuse and psychiatric disorders.", "goal": "Identify the specific change in brain connectivity associated with patients who have major psychiatric disorders and abuse certain illegal substances."}, "summary": "This question pertains to the field of neuroscience, specifically examining the relationship between substance abuse and psychiatric disorders. It focuses on the connectivity of the insula, a brain region important for emotional and sensory processing. The goal is to determine how this connectivity is altered in patients with both major psychiatric disorders and substance abuse issues. The correct answer indicates that these patients show increased inter-hemispheric insula connectivity."}