{"knowledge_schema": {"broad_category": "Genetics \u2192 Tumorigenesis \u2192 Genetic Alterations", "refinement": "This problem focuses on understanding the mechanisms of genetic alterations that can lead to changes in allele dosage and heterozygosity in the context of cancer development.", "specific_scope": "The question specifically addresses the concept of copy-neutral loss of heterozygosity, where the overall gene dosage remains the same despite the loss of one allele.", "goal": "Identify the genetic alteration that results in copy-neutral loss of heterozygosity while maintaining gene dosage."}, "summary": "In the context of tumorigenesis, the question asks which genetic alteration is most likely to lead to copy-neutral loss of heterozygosity, where the gene dosage is maintained despite the deletion of an allele. Among the options provided, uniparental disomy is the most relevant, as it involves the inheritance of both copies of a chromosome from one parent, resulting in the loss of heterozygosity while keeping the overall gene dosage unchanged."}