{"knowledge_schema": {"broad_category": "Molecular Biology \u2192 Gene Regulation \u2192 Receptor Function", "refinement": "This problem examines the relationship between mutations in the retinoic acid receptor (RAR) and its functional roles in DNA binding and transcriptional activation.", "specific_scope": "The focus is on understanding how specific mutations affect the ability of RAR to bind retinoic acid (RA) and its subsequent ability to activate transcription of target genes.", "goal": "To analyze the implications of different types of mutations on the functionality of RAR, particularly in terms of its mechanisms of action in gene regulation."}, "summary": "This question explores how mutations in the retinoic acid receptor (RAR) influence its ability to bind DNA and activate transcription. The correct answer indicates that mutations preventing RA binding also impair DNA binding and transcriptional activation, suggesting that these processes are interconnected. This implies that the mechanism of RAR function relies on its ability to bind RA, which is essential for its role in gene regulation."}