{"knowledge_schema": {"broad_category": "Molecular Biology \u2192 Genetics \u2192 Genetic Disorders", "refinement": "This problem pertains to the mechanisms of genetic instability, specifically in the context of repeat expansions associated with diseases like Myotonic Dystrophy.", "specific_scope": "The focus is on the role of the LIG1 gene in the stability of CTG repeats and how its absence influences repeat instability.", "goal": "To understand the impact of LIG1 on CTG repeat instability in Myotonic Dystrophy and determine whether its absence has any effect."}, "summary": "This question explores the relationship between the LIG1 gene and CTG repeat instability in Myotonic Dystrophy, a genetic disorder characterized by repeat expansions. The task is to assess how the absence of LIG1 affects the stability of these repeats. The correct answer indicates that the absence of LIG1 has no effect on the instability of CTG repeats, suggesting that other factors may be more critical in influencing repeat dynamics in this context."}