{"knowledge_schema": {"broad_category": "Pharmacology \u2192 Medication Safety \u2192 Buprenorphine/Naloxone Therapy", "refinement": "This problem focuses on the safety and efficacy of two formulations of buprenorphine: Subutex (buprenorphine only) and Suboxone (buprenorphine with naloxone).", "specific_scope": "The task involves evaluating statements regarding the safety profiles of Subutex and Suboxone based on evidence and clinical considerations.", "goal": "Identify which statements about the safety of Subutex and Suboxone are supported by evidence."}, "summary": "This question assesses the safety of buprenorphine formulations, Subutex and Suboxone, by evaluating various statements regarding their use and potential risks. The statements discuss the implications of naloxone in Suboxone, the safety of Subutex in specific populations, and the overall safety profiles of both medications. The goal is to determine which statements are evidence-based regarding their safety, considering factors like misuse potential and patient sensitivity."}