{"knowledge_schema": {"broad_category": "Molecular Biology \u2192 Gene Regulation \u2192 Receptor Function", "refinement": "This problem focuses on the functional analysis of retinoic acid receptors (RAR) and their mutants in relation to DNA binding and transcriptional activation.", "specific_scope": "The task involves evaluating the effects of specific mutations on the ability of RAR mutants to bind retinoic acid (RA) and DNA, and how these effects correlate with their transcriptional activation capabilities.", "goal": "Identify the correct statement that accurately describes the relationship between RAR mutants' ability to bind DNA and their implications for transcriptional activation."}, "summary": "This question examines the relationship between retinoic acid receptor (RAR) mutants and their functional capabilities in DNA binding and transcriptional activation. The task is to analyze various statements regarding the effects of specific mutations on RA binding and DNA binding, and how these relate to the overall transcriptional activity of the receptor. The goal is to determine which statement correctly reflects the mechanisms at play, particularly focusing on the correlation between RA binding, DNA binding, and transcriptional activation."}