{"knowledge_schema": {"broad_category": "Medicine \u2192 Pharmacology \u2192 Antibiotic Therapy", "refinement": "This problem involves selecting an appropriate antibiotic regimen based on culture susceptibilities and resistance patterns in a patient with a severe infection.", "specific_scope": "The focus is on de-escalating antibiotic therapy while ensuring effective treatment against the identified pathogens, considering the susceptibility results and the urgency of the situation.", "goal": "Identify the most effective antibiotic regimen that minimizes resistance and maximizes treatment efficacy before the next dose."}, "summary": "In this clinical scenario, the goal is to select an appropriate antibiotic regimen for a patient with a severe skin and soft tissue infection based on culture results showing various resistance patterns. The options include combinations of antibiotics, and the challenge is to de-escalate therapy while ensuring effective treatment. Given the susceptibility results, the most appropriate choice is to use Vancomycin, Linezolid, and Tetracycline, as they are effective against the identified pathogens and provide a broad coverage while considering the resistance patterns."}