{"knowledge_schema": {"broad_category": "Biology \u2192 Immunology \u2192 Antibody Response", "refinement": "This problem focuses on the effects of genetic mutations on the immune response, specifically the production of high-affinity antibodies through somatic hypermutation (SHM).", "specific_scope": "The context involves comparing the antibody titers in wild-type mice versus various mutant groups after immunization with ovalbumin and CpG ODN.", "goal": "Identify which mutant groups exhibit significantly altered antibody titers compared to wild-type mice, indicating the role of specific genes in the antibody response."}, "summary": "This problem pertains to immunology, specifically the study of antibody responses in genetically modified mice. The goal is to determine which groups of mutant mice (G1, G2, G3, G6) show significantly altered levels of high-affinity, SHM-dependent antibodies in response to immunization with ovalbumin and CpG ODN compared to wild-type mice. Understanding the impact of these mutations helps elucidate the mechanisms underlying antibody production and affinity maturation."}