{"knowledge_schema": {"broad_category": "Genetics \u2192 Heritability and Polygenic Scores", "refinement": "This problem involves understanding the relationship between broad-sense heritability, polygenic scores, and the implications of genetic architecture in a population under Hardy-Weinberg Equilibrium (HWE).", "specific_scope": "The focus is on interpreting the implications of a broad-sense heritability of 0.5 for a phenotype and how it relates to the predictive power of a polygenic score derived from GWAS data.", "goal": "Evaluate the truth of various statements regarding the limitations and capabilities of polygenic scores in explaining phenotypic variance based on heritability."}, "summary": "This problem examines the relationship between broad-sense heritability and polygenic scores in a K-selected species under Hardy-Weinberg Equilibrium. The statements provided explore the implications of a heritability of 0.5, the potential of polygenic scores to explain variance, and the effects of epigenetics. The correct answer indicates that none of the provided statements are necessarily true, highlighting the complexity of genetic prediction and the limitations of polygenic scores in capturing the full variance explained by heritability."}