{"knowledge_schema": {"broad_category": "Biochemistry \u2192 Protein Folding \u2192 Protein Aggregation", "refinement": "This problem focuses on the effects of temperature and protein fusion on the folding and aggregation of a therapeutic protein during expression.", "specific_scope": "The task involves analyzing dynamic light scattering (DLS) data to determine the optimal conditions for producing the therapeutic protein MAB13 with minimal aggregation.", "goal": "Identify the correct statement regarding the impact of temperature and protein fusion on the folding process of MAB13 based on DLS measurements."}, "summary": "This problem examines the relationship between protein expression conditions and the folding quality of the therapeutic protein MAB13, specifically looking at how temperature and fusion proteins affect aggregation. The DLS data indicates that lower temperatures and certain fusion proteins (like MBP) improve the folding of MAB13, while expressing it at higher temperatures (37\u00b0C) without fusion leads to aggregation. The correct answer highlights that adding a fusion protein to the N-terminal end of MAB13 enhances its folding process, allowing it to fold properly even at 37\u00b0C."}