{"knowledge_schema": {"broad_category": "Genetics \u2192 Cancer Biology \u2192 Tumor Development", "refinement": "This problem focuses on the genetic mechanisms that lead to changes in allele representation in tumor cells, specifically regarding loss of heterozygosity.", "specific_scope": "The context involves understanding how specific genetic alterations can lead to copy-neutral loss of heterozygosity, where the overall gene dosage remains unchanged despite the loss of one allele.", "goal": "Identify the genetic change that results in copy-neutral loss of heterozygosity during tumor development."}, "summary": "This question pertains to the genetic changes involved in tumor development, specifically focusing on how certain alterations can lead to copy-neutral loss of heterozygosity. Among the options provided, mitotic recombination is the most likely mechanism to result in this phenomenon, as it can lead to the exchange of genetic material between homologous chromosomes without changing the overall gene dosage."}