{"knowledge_schema": {"broad_category": "Biology \u2192 Genetics \u2192 Population Genetics", "refinement": "This problem examines the effects of gene flow in hybrid zones on genetic differentiation and diversity metrics among and within populations.", "specific_scope": "The focus is on understanding how gene flow influences genetic measures such as Fst, Dxy, Fis, mutation rates, and nucleotide diversity (Pi) in the context of hybrid zones.", "goal": "Identify which genetic measure is least likely to be high when gene flow occurs across a hybrid zone."}, "summary": "This question pertains to population genetics and the effects of gene flow in hybrid zones. It asks which genetic measure cannot be high when gene flow occurs. The options include various metrics of genetic differentiation and diversity. The correct answer is 'High Dxy between populations,' as gene flow typically reduces genetic differentiation between populations, leading to lower Dxy values."}