{"knowledge_schema": {"broad_category": "Pharmacology \u2192 Substance Use Treatment \u2192 Opioid Dependence Medications", "refinement": "This topic focuses on the safety profiles of medications used in the treatment of opioid dependence, specifically buprenorphine formulations.", "specific_scope": "The discussion centers on the comparison of Subutex (buprenorphine alone) and Suboxone (buprenorphine with naloxone) regarding their safety considerations for specific patient populations.", "goal": "Evaluate the safety implications of using buprenorphine without naloxone in different patient scenarios."}, "summary": "The question examines the safety considerations of using buprenorphine formulations, specifically Subutex and Suboxone. Subutex, which contains only buprenorphine, may be considered safer for certain patients, such as pregnant women or those who may be sensitive to naloxone, which is present in Suboxone. The correct statement reflects that Subutex might be a preferable option in these cases due to the absence of naloxone, which can induce withdrawal symptoms if misused."}