{"knowledge_schema": {"broad_category": "Biology \u2192 Genetics \u2192 Molecular Genetics", "refinement": "This problem pertains to the effects of specific gene knockouts on genetic stability, particularly in the context of a genetic disorder.", "specific_scope": "The focus is on the role of the LIG1 gene in the somatic instability of CTG repeats associated with Myotonic dystrophy.", "goal": "Determine the effect of LIG1 knockout on the stability of CTG repeats in the context of Myotonic dystrophy."}, "summary": "This question explores the relationship between the LIG1 gene and CTG somatic instability in Myotonic dystrophy. It requires understanding the role of LIG1 in DNA repair and replication processes, and how its knockout may influence the stability of CTG repeat expansions. The goal is to identify whether knocking out LIG1 leads to increased instability, reduced instability, contraction of repeat length, no impact, or if the knockout is lethal."}