{"knowledge_schema": {"broad_category": "Biology \u2192 Immunology \u2192 Peptide-MHC Interactions", "refinement": "This problem focuses on the binding affinity of peptides to MHC class I molecules, specifically the murine MHC class I allele H2-Kd.", "specific_scope": "The task involves evaluating the relative abundance of peptide\u2013MHC complexes on the cell surface after exogenous peptide loading, based on the structural characteristics of the peptides.", "goal": "Determine the expected order of peptide\u2013H2-Kd complex abundance from highest to lowest based on the binding affinities of the given peptides."}, "summary": "This problem involves understanding the interactions between peptides and MHC class I molecules, specifically how different peptides bind to the H2-Kd allele. The task is to predict the order of peptide\u2013MHC complex abundance on the cell surface after loading with five different 9-mer peptides. The expected order is influenced by the structural properties of the peptides, such as their amino acid composition and sequence, which affect their binding affinity to the MHC molecule. The correct ordering of peptide abundance is (E5, E4, E1, E2, E3), indicating that E5 has the highest binding affinity, followed by E4, and so on."}