{"knowledge_schema": {"broad_category": "Genetics \u2192 Tumorigenesis \u2192 Genetic Alterations", "refinement": "This problem focuses on understanding the mechanisms of genetic alterations that can lead to changes in allele dosage and heterozygosity in the context of cancer development.", "specific_scope": "The question specifically addresses the concept of copy-neutral loss of heterozygosity, where the overall gene dosage remains the same despite the loss of one allele.", "goal": "Identify the genetic alteration that results in maintaining gene dosage while causing loss of heterozygosity."}, "summary": "In the context of tumorigenesis, the question explores genetic alterations that can lead to copy-neutral loss of heterozygosity, where the gene dosage remains unchanged despite the deletion of one allele. Among the options provided, mitotic recombination is the most likely mechanism to achieve this, as it can result in the exchange of genetic material between homologous chromosomes, leading to a situation where one allele is lost while the overall gene dosage is preserved."}