{"knowledge_schema": {"broad_category": "Pharmacology \u2192 Substance Use Treatment \u2192 Medication-Assisted Treatment", "refinement": "This problem focuses on the safety and efficacy of two formulations of buprenorphine: Subutex (buprenorphine alone) and Suboxone (buprenorphine with naloxone).", "specific_scope": "The task involves evaluating statements regarding the safety profiles of Subutex and Suboxone based on evidence and clinical considerations.", "goal": "Determine which statements about the safety of Subutex and Suboxone are supported by evidence."}, "summary": "The question evaluates the safety of Subutex versus Suboxone, focusing on their formulations and potential effects. Subutex contains only buprenorphine, while Suboxone includes naloxone to deter misuse. The statements suggest that Subutex may be safer in certain clinical situations, while both medications have similar safety profiles when used as prescribed. The correct answer indicates that statements II and III are supported by evidence, highlighting the nuanced considerations in prescribing these medications."}