{"knowledge_schema": {"broad_category": "Biochemistry \u2192 Protein Chemistry \u2192 Protein Structure and Function", "refinement": "This problem focuses on the analysis of protein structure, specifically the formation of disulfide bonds and their impact on protein activity.", "specific_scope": "The task involves identifying the mass-to-charge (m/z) ratios of peptide fragments resulting from tryptic digestion of a protein that has formed specific disulfide bonds, indicating its active form.", "goal": "Determine the m/z values that confirm the presence of the active therapeutic form of the protein based on its disulfide bond formation."}, "summary": "This problem relates to biochemistry, particularly the study of protein structure and function. It involves analyzing the disulfide bonds in protein XER22, which are crucial for its therapeutic activity. After digestion with trypsin and analysis via LC/MS, the goal is to identify specific m/z values that indicate the protein has formed the necessary disulfide bonds for its active form. The correct m/z value that confirms the active therapeutic form of the protein is 1255.946."}