{"knowledge_schema": {"broad_category": "Genetics \u2192 Genetic Disorders", "refinement": "This category includes various genetic conditions that can affect metabolic processes in the body.", "specific_scope": "The focus is on genetic disorders specifically linked to mutations on chromosome 2 and their impact on basal metabolic rate (BMR).", "goal": "Identify the genetic disorder from the provided list that is associated with the highest increase in patients' basal metabolic rate due to mutations on chromosome 2."}, "summary": "This question pertains to genetic disorders, particularly those caused by mutations on chromosome 2, and their effects on basal metabolic rate (BMR). The task is to determine which disorder from the given list leads to the greatest increase in BMR. Understanding the metabolic implications of these disorders is crucial for identifying the correct answer."}