{"knowledge_schema": {"broad_category": "Biology \u2192 Genetics \u2192 Population Genetics", "refinement": "This problem focuses on the effects of gene flow in hybrid zones and how it influences genetic diversity and structure within and between populations.", "specific_scope": "The question examines the implications of gene flow on various genetic metrics such as Fst, Dxy, Fis, mutation rate, and nucleotide diversity (Pi) within populations.", "goal": "Identify which of the provided genetic metrics cannot be high when gene flow occurs across a hybrid zone."}, "summary": "This question pertains to population genetics and the effects of gene flow in hybrid zones. It asks which genetic metric cannot be high when gene flow is present. The options include measures of genetic differentiation (Fst, Dxy), inbreeding (Fis), mutation rate (u), and nucleotide diversity (Pi). Understanding the relationships between these metrics and gene flow is crucial for answering the question."}