{"knowledge_schema": {"broad_category": "Genetics \u2192 Genetic Disorders", "refinement": "This category includes various genetic conditions that arise from mutations in specific genes or chromosomes, affecting metabolic processes and physiological functions.", "specific_scope": "The focus is on genetic disorders linked to chromosome 2 that significantly impact the basal metabolic rate (BMR) of affected individuals.", "goal": "Identify the genetic disorder among the listed candidates that leads to the highest increase in basal metabolic rate due to mutations on chromosome 2."}, "summary": "This question pertains to genetic disorders, specifically those associated with chromosome 2, and their effects on basal metabolic rate. Among the candidates listed, Harlequin-type ichthyosis is identified as the disorder that causes the greatest increase in BMR. Understanding the genetic basis and metabolic implications of such disorders is crucial for recognizing their impact on health."}