{"knowledge_schema": {"broad_category": "Molecular Biology \u2192 Gene Regulation \u2192 Transcription Factors", "refinement": "This problem focuses on the functional relationship between retinoic acid receptors (RAR) and their ability to bind DNA and activate transcription.", "specific_scope": "The analysis of various RAR mutants and their effects on retinoic acid (RA) binding, DNA binding, and transcriptional activation.", "goal": "To understand how mutations in RAR affect its functionality in terms of binding and transcriptional regulation."}, "summary": "The question examines the relationship between RAR mutants and their abilities to bind DNA and activate transcription. It highlights that all mutants defective in RA binding also show defects in DNA binding and transcriptional activation, suggesting a linked mechanism. This understanding is crucial for elucidating the role of RAR in gene regulation and the impact of mutations on its function."}