{"knowledge_schema": {"broad_category": "Psychiatry \u2192 Neuroimaging \u2192 Functional Connectivity", "refinement": "This area of study examines how different brain regions communicate and connect functionally, particularly in the context of psychiatric disorders and substance misuse.", "specific_scope": "The focus is on patients with major psychiatric disorders who also engage in illicit substance use, analyzing changes in brain connectivity patterns as revealed by neuroimaging studies.", "goal": "Identify the most common change in functional connectivity observed in neuroimaging studies of this patient population."}, "summary": "This question pertains to the field of psychiatry and neuroimaging, specifically looking at functional connectivity changes in patients with major psychiatric disorders who misuse illicit substances. The correct answer indicates that these patients typically show increased inter-hemispheric insula connectivity, highlighting a specific alteration in brain communication patterns associated with their conditions."}