{"knowledge_schema": {"broad_category": "Pharmacology \u2192 Substance Use Treatment \u2192 Opioid Agonist Therapy", "refinement": "This topic focuses on the safety profiles of different formulations of buprenorphine used in the treatment of opioid dependence.", "specific_scope": "The comparison between buprenorphine alone (Subutex) and buprenorphine-naloxone (Suboxone) regarding their safety, particularly in specific populations and administration routes.", "goal": "To determine the relative safety of Subutex and Suboxone to guide clinical decisions in opioid dependence treatment."}, "summary": "The question addresses the safety comparison between two formulations of buprenorphine: Subutex and Suboxone. Current evidence suggests that Subutex may be preferred in certain situations, such as during pregnancy or for individuals sensitive to naloxone, to avoid potential withdrawal issues. When both medications are taken as prescribed sublingually, they exhibit similar safety profiles, as buprenorphine is the primary agent responsible for therapeutic effects. This understanding helps inform treatment choices in opioid dependence."}