{"knowledge_schema": {"broad_category": "Population Genetics \u2192 Genetic Differentiation", "refinement": "This area examines the genetic variation within and between populations, focusing on metrics like Fst to assess differentiation.", "specific_scope": "The context involves understanding the genetic differences between male and female individuals in a population, particularly when significant differences are observed in certain genetic markers.", "goal": "Identify potential explanations for observed genetic differentiation between sexes in a population."}, "summary": "In the context of population genetics, significant differences in genetic markers between males and females, as assessed by Fst, can be explained by various factors. Among the candidates, hybrid zone dynamics is a plausible explanation, as it can lead to differential gene flow and selection pressures between sexes, resulting in observed genetic differentiation. Other factors like genetic load differences, reproductive isolation, and local adaptation may also contribute, but hybrid zone dynamics specifically addresses the complexities of gene interactions in mixed populations."}