{"knowledge_schema": {"broad_category": "Biology \u2192 Immunology \u2192 MHC-Epitope Interactions", "refinement": "This problem focuses on the binding affinity of various epitopes to the MHC class I molecule H2-Kd and how this affects their presentation on the cell surface.", "specific_scope": "The task involves ranking different epitopes based on their expected binding affinity to H2-Kd, which influences their presence at the cell surface in a controlled experimental setup.", "goal": "Determine the order of epitopes based on their predicted binding strength to H2-Kd, which will dictate their complexed amounts at the cell surface."}, "summary": "This problem involves understanding the interactions between epitopes and MHC molecules, specifically the H2-Kd allele in BALB/c mice. The researcher tests five different epitopes for their ability to bind to H2-Kd and ranks them based on their expected binding affinities. The epitope with the highest binding affinity will be found in the greatest amount at the cell surface, while those with lower affinities will be present in lesser amounts. The goal is to accurately rank the epitopes from highest to lowest expected complexed amounts."}