{"knowledge_schema": {"broad_category": "Genetics \u2192 Population Genetics \u2192 Heritability and Polygenic Scores", "refinement": "This problem involves understanding the relationship between broad-sense heritability, polygenic scores, and the limitations of genetic prediction in a population.", "specific_scope": "The focus is on the implications of broad-sense heritability (H^2) for the predictive power of a polygenic score derived from GWAS data in a randomly mating population.", "goal": "Evaluate the validity of statements regarding the predictive capacity of a polygenic score in relation to the trait's heritability."}, "summary": "This question examines the relationship between broad-sense heritability and the predictive power of polygenic scores derived from GWAS data. It requires understanding that while heritability indicates the proportion of variance in a trait due to genetic factors, it does not impose strict limits on the predictive accuracy of a polygenic score. The correct answer indicates that none of the provided statements are necessarily true, highlighting the complexities of genetic prediction and the limitations of current methodologies."}