Based on prior knowledge, the slope of the peak exercise ST segment (ST_Slope) can be an important indicator of heart disease. Here's the analysis:

- Upward Slope (ST_Slope = 'Up'): This could indicate an increased risk of heart disease. In patients with heart disease, an upward slope may suggest ischemia or injury to the heart muscle during exercise.

- Flat Slope (ST_Slope = 'Flat'): This could also suggest an increased risk of heart disease. A flat slope may indicate a lack of blood flow or reduced oxygen supply to the heart during exercise, which can be a sign of coronary artery disease.

- Downward Slope (ST_Slope = 'Down'): This slope is less likely to be associated with heart disease. A downward slope may indicate a normal response to exercise, where the blood flow and oxygen supply to the heart increase efficiently.

Based on this analysis, the dictionary can be created as follows:

```json
{
	"no": ["Flat"],
	"yes": ["Up", "Down"]
}
```

Note: Since the downward slope is less likely to be associated with heart disease, we have excluded it from the "no" list.