import argparse
import os.path

def main(args):

    import json, time, os, sys, glob
    import shutil
    import warnings
    import numpy as np
    import torch
    from torch import optim
    from torch.utils.data import DataLoader
    from torch.utils.data.dataset import random_split, Subset
    import copy
    import torch.nn as nn
    import torch.nn.functional as F
    import random
    import os.path
    import subprocess
    
    from protein_mpnn_utils import loss_nll, loss_smoothed, gather_edges, gather_nodes, gather_nodes_t, cat_neighbors_nodes, _scores, _S_to_seq, tied_featurize, parse_PDB
    from protein_mpnn_utils import StructureDataset, StructureDatasetPDB, ProteinMPNN

    if args.seed:
        seed=args.seed
    else:
        seed=int(np.random.randint(0, high=999, size=1, dtype=int)[0])

    torch.manual_seed(seed)
    random.seed(seed)
    np.random.seed(seed)   
    
    hidden_dim = 128
    num_layers = 3 
  

    if args.path_to_model_weights:
        model_folder_path = args.path_to_model_weights
        if model_folder_path[-1] != '/':
            model_folder_path = model_folder_path + '/'
    else: 
        file_path = os.path.realpath(__file__)
        k = file_path.rfind("/")
        if args.ca_only:
            model_folder_path = file_path[:k] + '/ca_model_weights/'
        else:
            model_folder_path = file_path[:k] + '/vanilla_model_weights/'

    checkpoint_path = model_folder_path + f'{args.model_name}.pt'
    folder_for_outputs = args.out_folder
    
    NUM_BATCHES = args.num_seq_per_target//args.batch_size
    BATCH_COPIES = args.batch_size
    temperatures = [float(item) for item in args.sampling_temp.split()]
    omit_AAs_list = args.omit_AAs
    alphabet = 'ACDEFGHIKLMNPQRSTVWYX'
    
    omit_AAs_np = np.array([AA in omit_AAs_list for AA in alphabet]).astype(np.float32)
    device = torch.device(f"cuda:{args.device}" if (torch.cuda.is_available()) else "cpu")
    if os.path.isfile(args.chain_id_jsonl):
        with open(args.chain_id_jsonl, 'r') as json_file:
            json_list = list(json_file)
        for json_str in json_list:
            chain_id_dict = json.loads(json_str)
    else:
        chain_id_dict = None
        print(40*'-')
        print('chain_id_jsonl is NOT loaded')
        
    if os.path.isfile(args.fixed_positions_jsonl):
        with open(args.fixed_positions_jsonl, 'r') as json_file:
            json_list = list(json_file)
        for json_str in json_list:
            fixed_positions_dict = json.loads(json_str)
    else:
        print(40*'-')
        print('fixed_positions_jsonl is NOT loaded')
        fixed_positions_dict = None
    
    
    if os.path.isfile(args.pssm_jsonl):
        with open(args.pssm_jsonl, 'r') as json_file:
            json_list = list(json_file)
        pssm_dict = {}
        for json_str in json_list:
            pssm_dict.update(json.loads(json_str))
    else:
        print(40*'-')
        print('pssm_jsonl is NOT loaded')
        pssm_dict = None
    
    
    if os.path.isfile(args.omit_AA_jsonl):
        with open(args.omit_AA_jsonl, 'r') as json_file:
            json_list = list(json_file)
        for json_str in json_list:
            omit_AA_dict = json.loads(json_str)
    else:
        print(40*'-')
        print('omit_AA_jsonl is NOT loaded')
        omit_AA_dict = None
    
    
    if os.path.isfile(args.bias_AA_jsonl):
        with open(args.bias_AA_jsonl, 'r') as json_file:
            json_list = list(json_file)
        for json_str in json_list:
            bias_AA_dict = json.loads(json_str)
    else:
        print(40*'-')
        print('bias_AA_jsonl is NOT loaded')
        bias_AA_dict = None
    
    
    if os.path.isfile(args.tied_positions_jsonl):
        with open(args.tied_positions_jsonl, 'r') as json_file:
            json_list = list(json_file)
        for json_str in json_list:
            tied_positions_dict = json.loads(json_str)
    else:
        print(40*'-')
        print('tied_positions_jsonl is NOT loaded')
        tied_positions_dict = None

    
    if os.path.isfile(args.bias_by_res_jsonl):
        with open(args.bias_by_res_jsonl, 'r') as json_file:
            json_list = list(json_file)
    
        for json_str in json_list:
            bias_by_res_dict = json.loads(json_str)
        print('bias by residue dictionary is loaded')
    else:
        print(40*'-')
        print('bias by residue dictionary is not loaded, or not provided')
        bias_by_res_dict = None
   

 
    print(40*'-')
    bias_AAs_np = np.zeros(len(alphabet))
    if bias_AA_dict:
            for n, AA in enumerate(alphabet):
                    if AA in list(bias_AA_dict.keys()):
                            bias_AAs_np[n] = bias_AA_dict[AA]
    
    if args.pdb_path:
        pdb_dict_list = parse_PDB(args.pdb_path, ca_only=args.ca_only)
        dataset_valid = StructureDatasetPDB(pdb_dict_list, truncate=None, max_length=args.max_length)
        all_chain_list = [item[-1:] for item in list(pdb_dict_list[0]) if item[:9]=='seq_chain'] #['A','B', 'C',...]
        if args.pdb_path_chains:
            designed_chain_list = [str(item) for item in args.pdb_path_chains.split()]
        else:
            designed_chain_list = all_chain_list
        fixed_chain_list = [letter for letter in all_chain_list if letter not in designed_chain_list]
        chain_id_dict = {}
        chain_id_dict[pdb_dict_list[0]['name']]= (designed_chain_list, fixed_chain_list)
    else:
        dataset_valid = StructureDataset(args.jsonl_path, truncate=None, max_length=args.max_length)

    print(40*'-')
    checkpoint = torch.load(checkpoint_path, map_location=device) 
    print('Number of edges:', checkpoint['num_edges'])
    noise_level_print = checkpoint['noise_level']
    print(f'Training noise level: {noise_level_print}A')
    model = ProteinMPNN(ca_only=args.ca_only, num_letters=21, node_features=hidden_dim, edge_features=hidden_dim, hidden_dim=hidden_dim, num_encoder_layers=num_layers, num_decoder_layers=num_layers, augment_eps=args.backbone_noise, k_neighbors=checkpoint['num_edges'])
    model.to(device)
    model.load_state_dict(checkpoint['model_state_dict'])
    model.eval()
    
    # Build paths for experiment
    base_folder = folder_for_outputs
    if base_folder[-1] != '/':
        base_folder = base_folder + '/'
    if not os.path.exists(base_folder):
        os.makedirs(base_folder)
    
    if not os.path.exists(base_folder + 'seqs'):
        os.makedirs(base_folder + 'seqs')
    
    if args.save_score:
        if not os.path.exists(base_folder + 'scores'):
            os.makedirs(base_folder + 'scores')

    if args.score_only:
        if not os.path.exists(base_folder + 'score_only'):
            os.makedirs(base_folder + 'score_only')
   

    if args.conditional_probs_only:
        if not os.path.exists(base_folder + 'conditional_probs_only'):
            os.makedirs(base_folder + 'conditional_probs_only')

    if args.unconditional_probs_only:
        if not os.path.exists(base_folder + 'unconditional_probs_only'):
            os.makedirs(base_folder + 'unconditional_probs_only')
 
    if args.save_probs:
        if not os.path.exists(base_folder + 'probs'):
            os.makedirs(base_folder + 'probs') 
    
    # Timing
    start_time = time.time()
    total_residues = 0
    protein_list = []
    total_step = 0
    # Validation epoch
    with torch.no_grad():
        test_sum, test_weights = 0., 0.
        #print('Generating sequences...')
        for ix, protein in enumerate(dataset_valid):
            score_list = []
            global_score_list = []
            all_probs_list = []
            all_decoding_orders = []
            all_log_probs_list = []
            S_sample_list = []
            batch_clones = [copy.deepcopy(protein) for i in range(BATCH_COPIES)]
            X, S, mask, lengths, chain_M, chain_encoding_all, chain_list_list, visible_list_list, masked_list_list, masked_chain_length_list_list, chain_M_pos, omit_AA_mask, residue_idx, dihedral_mask, tied_pos_list_of_lists_list, pssm_coef, pssm_bias, pssm_log_odds_all, bias_by_res_all, tied_beta = tied_featurize(batch_clones, device, chain_id_dict, fixed_positions_dict, omit_AA_dict, tied_positions_dict, pssm_dict, bias_by_res_dict, ca_only=args.ca_only)
            pssm_log_odds_mask = (pssm_log_odds_all > args.pssm_threshold).float() #1.0 for true, 0.0 for false
            name_ = batch_clones[0]['name']
            if args.score_only:
                structure_sequence_score_file = base_folder + '/score_only/' + batch_clones[0]['name'] + '.npz'
                native_score_list = []
                global_native_score_list = []
                for j in range(NUM_BATCHES):
                    randn_1 = torch.randn(chain_M.shape, device=X.device)
                    log_probs = model(X, S, mask, chain_M*chain_M_pos, residue_idx, chain_encoding_all, randn_1)
                    mask_for_loss = mask*chain_M*chain_M_pos
                    scores = _scores(S, log_probs, mask_for_loss)
                    native_score = scores.cpu().data.numpy()
                    native_score_list.append(native_score)
                    global_scores = _scores(S, log_probs, mask)
                    global_native_score = global_scores.cpu().data.numpy()
                    global_native_score_list.append(global_native_score)
                native_score = np.concatenate(native_score_list, 0)
                global_native_score = np.concatenate(global_native_score_list, 0)
                ns_mean = native_score.mean()
                ns_mean_print = np.format_float_positional(np.float32(ns_mean), unique=False, precision=4)
                ns_std = native_score.std()
                ns_std_print = np.format_float_positional(np.float32(ns_std), unique=False, precision=4)

                global_ns_mean = global_native_score.mean()
                global_ns_mean_print = np.format_float_positional(np.float32(global_ns_mean), unique=False, precision=4)
                global_ns_std = global_native_score.std()
                global_ns_std_print = np.format_float_positional(np.float32(global_ns_std), unique=False, precision=4)

                ns_sample_size = native_score.shape[0]
                np.savez(structure_sequence_score_file, score=native_score, global_score=global_native_score)
                print(f'Score for {name_}, mean: {ns_mean_print}, std: {ns_std_print}, sample size: {ns_sample_size},  Global Score for {name_}, mean: {global_ns_mean_print}, std: {global_ns_std_print}, sample size: {ns_sample_size}')
            elif args.conditional_probs_only:
                print(f'Calculating conditional probabilities for {name_}')
                conditional_probs_only_file = base_folder + '/conditional_probs_only/' + batch_clones[0]['name']
                log_conditional_probs_list = []
                for j in range(NUM_BATCHES):
                    randn_1 = torch.randn(chain_M.shape, device=X.device)
                    log_conditional_probs = model.conditional_probs(X, S, mask, chain_M*chain_M_pos, residue_idx, chain_encoding_all, randn_1, args.conditional_probs_only_backbone)
                    log_conditional_probs_list.append(log_conditional_probs.cpu().numpy())
                concat_log_p = np.concatenate(log_conditional_probs_list, 0) #[B, L, 21]
                mask_out = (chain_M*chain_M_pos*mask)[0,].cpu().numpy()
                np.savez(conditional_probs_only_file, log_p=concat_log_p, S=S[0,].cpu().numpy(), mask=mask[0,].cpu().numpy(), design_mask=mask_out)
            elif args.unconditional_probs_only:
                print(f'Calculating sequence unconditional probabilities for {name_}')
                unconditional_probs_only_file = base_folder + '/unconditional_probs_only/' + batch_clones[0]['name']
                log_unconditional_probs_list = []
                for j in range(NUM_BATCHES):
                    log_unconditional_probs = model.unconditional_probs(X, mask, residue_idx, chain_encoding_all)
                    log_unconditional_probs_list.append(log_unconditional_probs.cpu().numpy())
                concat_log_p = np.concatenate(log_unconditional_probs_list, 0) #[B, L, 21]
                mask_out = (chain_M*chain_M_pos*mask)[0,].cpu().numpy()
                np.savez(unconditional_probs_only_file, log_p=concat_log_p, S=S[0,].cpu().numpy(), mask=mask[0,].cpu().numpy(), design_mask=mask_out)
            else:
                randn_1 = torch.randn(chain_M.shape, device=X.device)
                log_probs = model(X, S, mask, chain_M*chain_M_pos, residue_idx, chain_encoding_all, randn_1)
                mask_for_loss = mask*chain_M*chain_M_pos
                scores = _scores(S, log_probs, mask_for_loss) #score only the redesigned part
                native_score = scores.cpu().data.numpy()
                global_scores = _scores(S, log_probs, mask) #score the whole structure-sequence
                global_native_score = global_scores.cpu().data.numpy()
                # Generate some sequences
                ali_file = base_folder + '/seqs/' + batch_clones[0]['name'] + '.fa'
                score_file = base_folder + '/scores/' + batch_clones[0]['name'] + '.npz'
                probs_file = base_folder + '/probs/' + batch_clones[0]['name'] + '.npz'
                print(f'Generating sequences for: {name_}')
                t0 = time.time()
                with open(ali_file, 'w') as f:
                    for temp in temperatures:
                        for j in range(NUM_BATCHES):
                            randn_2 = torch.randn(chain_M.shape, device=X.device)
                            if tied_positions_dict == None:
                                sample_dict = model.sample(X, randn_2, S, chain_M, chain_encoding_all, residue_idx, mask=mask, temperature=temp, omit_AAs_np=omit_AAs_np, bias_AAs_np=bias_AAs_np, chain_M_pos=chain_M_pos, omit_AA_mask=omit_AA_mask, pssm_coef=pssm_coef, pssm_bias=pssm_bias, pssm_multi=args.pssm_multi, pssm_log_odds_flag=bool(args.pssm_log_odds_flag), pssm_log_odds_mask=pssm_log_odds_mask, pssm_bias_flag=bool(args.pssm_bias_flag), bias_by_res=bias_by_res_all)
                                S_sample = sample_dict["S"] 
                            else:
                                sample_dict = model.tied_sample(X, randn_2, S, chain_M, chain_encoding_all, residue_idx, mask=mask, temperature=temp, omit_AAs_np=omit_AAs_np, bias_AAs_np=bias_AAs_np, chain_M_pos=chain_M_pos, omit_AA_mask=omit_AA_mask, pssm_coef=pssm_coef, pssm_bias=pssm_bias, pssm_multi=args.pssm_multi, pssm_log_odds_flag=bool(args.pssm_log_odds_flag), pssm_log_odds_mask=pssm_log_odds_mask, pssm_bias_flag=bool(args.pssm_bias_flag), tied_pos=tied_pos_list_of_lists_list[0], tied_beta=tied_beta, bias_by_res=bias_by_res_all)
                            # Compute scores
                                S_sample = sample_dict["S"]
                            log_probs = model(X, S_sample, mask, chain_M*chain_M_pos, residue_idx, chain_encoding_all, randn_2, use_input_decoding_order=True, decoding_order=sample_dict["decoding_order"])
                            mask_for_loss = mask*chain_M*chain_M_pos
                            scores = _scores(S_sample, log_probs, mask_for_loss)
                            scores = scores.cpu().data.numpy()
                            
                            global_scores = _scores(S_sample, log_probs, mask) #score the whole structure-sequence
                            global_scores = global_scores.cpu().data.numpy()
                            
                            all_probs_list.append(sample_dict["probs"].cpu().data.numpy())
                            all_decoding_orders.append(sample_dict["decoding_order"].cpu().data.numpy())
                            all_log_probs_list.append(log_probs.cpu().data.numpy())
                            S_sample_list.append(S_sample.cpu().data.numpy())
                            for b_ix in range(BATCH_COPIES):
                                masked_chain_length_list = masked_chain_length_list_list[b_ix]
                                masked_list = masked_list_list[b_ix]
                                seq_recovery_rate = torch.sum(torch.sum(torch.nn.functional.one_hot(S[b_ix], 21)*torch.nn.functional.one_hot(S_sample[b_ix], 21),axis=-1)*mask_for_loss[b_ix])/torch.sum(mask_for_loss[b_ix])
                                seq = _S_to_seq(S_sample[b_ix], chain_M[b_ix])
                                score = scores[b_ix]
                                score_list.append(score)
                                global_score = global_scores[b_ix]
                                global_score_list.append(global_score)
                                native_seq = _S_to_seq(S[b_ix], chain_M[b_ix])
                                if b_ix == 0 and j==0 and temp==temperatures[0]:
                                    start = 0
                                    end = 0
                                    list_of_AAs = []
                                    for mask_l in masked_chain_length_list:
                                        end += mask_l
                                        list_of_AAs.append(native_seq[start:end])
                                        start = end
                                    native_seq = "".join(list(np.array(list_of_AAs)[np.argsort(masked_list)]))
                                    l0 = 0
                                    for mc_length in list(np.array(masked_chain_length_list)[np.argsort(masked_list)])[:-1]:
                                        l0 += mc_length
                                        native_seq = native_seq[:l0] + '/' + native_seq[l0:]
                                        l0 += 1
                                    sorted_masked_chain_letters = np.argsort(masked_list_list[0])
                                    print_masked_chains = [masked_list_list[0][i] for i in sorted_masked_chain_letters]
                                    sorted_visible_chain_letters = np.argsort(visible_list_list[0])
                                    print_visible_chains = [visible_list_list[0][i] for i in sorted_visible_chain_letters]
                                    native_score_print = np.format_float_positional(np.float32(native_score.mean()), unique=False, precision=4)
                                    global_native_score_print = np.format_float_positional(np.float32(global_native_score.mean()), unique=False, precision=4)
                                    script_dir = os.path.dirname(os.path.realpath(__file__))
                                    try:
                                        commit_str = subprocess.check_output(f'git --git-dir {script_dir}/.git rev-parse HEAD', shell=True).decode().strip()
                                    except subprocess.CalledProcessError:
                                        commit_str = 'unknown'
                                    if args.ca_only:
                                        print_model_name = 'CA_model_name'
                                    else:
                                        print_model_name = 'model_name'
                                    f.write('>{}, score={}, global_score={}, fixed_chains={}, designed_chains={}, {}={}, git_hash={}, seed={}\n{}\n'.format(name_, native_score_print, global_native_score_print, print_visible_chains, print_masked_chains, print_model_name, args.model_name, commit_str, seed, native_seq)) #write the native sequence
                                start = 0
                                end = 0
                                list_of_AAs = []
                                for mask_l in masked_chain_length_list:
                                    end += mask_l
                                    list_of_AAs.append(seq[start:end])
                                    start = end
    
                                seq = "".join(list(np.array(list_of_AAs)[np.argsort(masked_list)]))
                                l0 = 0
                                for mc_length in list(np.array(masked_chain_length_list)[np.argsort(masked_list)])[:-1]:
                                    l0 += mc_length
                                    seq = seq[:l0] + '/' + seq[l0:]
                                    l0 += 1
                                score_print = np.format_float_positional(np.float32(score), unique=False, precision=4)
                                global_score_print = np.format_float_positional(np.float32(global_score), unique=False, precision=4)
                                seq_rec_print = np.format_float_positional(np.float32(seq_recovery_rate.detach().cpu().numpy()), unique=False, precision=4)
                                sample_number = j*BATCH_COPIES+b_ix+1
                                f.write('>T={}, sample={}, score={}, global_score={}, seq_recovery={}\n{}\n'.format(temp,sample_number,score_print,global_score_print,seq_rec_print,seq)) #write generated sequence
                if args.save_score:
                    np.savez(score_file, score=np.array(score_list, np.float32), global_score=np.array(global_score_list, np.float32))
                if args.save_probs:
                    all_probs_concat = np.concatenate(all_probs_list)
                    all_log_probs_concat = np.concatenate(all_log_probs_list)
                    S_sample_concat = np.concatenate(S_sample_list)
                    np.savez(probs_file, probs=np.array(all_probs_concat, np.float32), log_probs=np.array(all_log_probs_concat, np.float32), S=np.array(S_sample_concat, int), mask=mask_for_loss.cpu().data.numpy(), chain_order=chain_list_list)
                t1 = time.time()
                dt = round(float(t1-t0), 4)
                num_seqs = len(temperatures)*NUM_BATCHES*BATCH_COPIES
                total_length = X.shape[1]
                print(f'{num_seqs} sequences of length {total_length} generated in {dt} seconds')
   
if __name__ == "__main__":
    argparser = argparse.ArgumentParser(formatter_class=argparse.ArgumentDefaultsHelpFormatter)
 
    argparser.add_argument("--ca_only", action="store_true", default=False, help="Parse CA-only structures and use CA-only models (default: false)")   
    argparser.add_argument("--path_to_model_weights", type=str, default="", help="Path to model weights folder;") 
    argparser.add_argument("--device", type=str, default="0", help="CUDA device to use;")
    argparser.add_argument("--model_name", type=str, default="v_48_020", help="ProteinMPNN model name: v_48_002, v_48_010, v_48_020, v_48_030; v_48_010=version with 48 edges 0.10A noise")

    argparser.add_argument("--seed", type=int, default=0, help="If set to 0 then a random seed will be picked;")
 
    argparser.add_argument("--save_score", type=int, default=0, help="0 for False, 1 for True; save score=-log_prob to npy files")
    argparser.add_argument("--save_probs", type=int, default=0, help="0 for False, 1 for True; save MPNN predicted probabilites per position")

    argparser.add_argument("--score_only", type=int, default=0, help="0 for False, 1 for True; score input backbone-sequence pairs")

    argparser.add_argument("--conditional_probs_only", type=int, default=0, help="0 for False, 1 for True; output conditional probabilities p(s_i given the rest of the sequence and backbone)")    
    argparser.add_argument("--conditional_probs_only_backbone", type=int, default=0, help="0 for False, 1 for True; if true output conditional probabilities p(s_i given backbone)") 
    argparser.add_argument("--unconditional_probs_only", type=int, default=0, help="0 for False, 1 for True; output unconditional probabilities p(s_i given backbone) in one forward pass")   
 
    argparser.add_argument("--backbone_noise", type=float, default=0.00, help="Standard deviation of Gaussian noise to add to backbone atoms")
    argparser.add_argument("--num_seq_per_target", type=int, default=1, help="Number of sequences to generate per target")
    argparser.add_argument("--batch_size", type=int, default=1, help="Batch size; can set higher for titan, quadro GPUs, reduce this if running out of GPU memory")
    argparser.add_argument("--max_length", type=int, default=200000, help="Max sequence length")
    argparser.add_argument("--sampling_temp", type=str, default="0.1", help="A string of temperatures, 0.2 0.25 0.5. Sampling temperature for amino acids. Suggested values 0.1, 0.15, 0.2, 0.25, 0.3. Higher values will lead to more diversity.")
    
    argparser.add_argument("--out_folder", type=str, help="Path to a folder to output sequences, e.g. /home/out/")
    argparser.add_argument("--pdb_path", type=str, default='', help="Path to a single PDB to be designed")
    argparser.add_argument("--pdb_path_chains", type=str, default='', help="Define which chains need to be designed for a single PDB ")
    argparser.add_argument("--jsonl_path", type=str, help="Path to a folder with parsed pdb into jsonl")
    argparser.add_argument("--chain_id_jsonl",type=str, default='', help="Path to a dictionary specifying which chains need to be designed and which ones are fixed, if not specied all chains will be designed.")
    argparser.add_argument("--fixed_positions_jsonl", type=str, default='', help="Path to a dictionary with fixed positions")
    argparser.add_argument("--omit_AAs", type=list, default='X', help="Specify which amino acids should be omitted in the generated sequence, e.g. 'AC' would omit alanine and cystine.")
    argparser.add_argument("--bias_AA_jsonl", type=str, default='', help="Path to a dictionary which specifies AA composion bias if neededi, e.g. {A: -1.1, F: 0.7} would make A less likely and F more likely.")
   
    argparser.add_argument("--bias_by_res_jsonl", default='', help="Path to dictionary with per position bias.") 
    argparser.add_argument("--omit_AA_jsonl", type=str, default='', help="Path to a dictionary which specifies which amino acids need to be omited from design at specific chain indices")
    argparser.add_argument("--pssm_jsonl", type=str, default='', help="Path to a dictionary with pssm")
    argparser.add_argument("--pssm_multi", type=float, default=0.0, help="A value between [0.0, 1.0], 0.0 means do not use pssm, 1.0 ignore MPNN predictions")
    argparser.add_argument("--pssm_threshold", type=float, default=0.0, help="A value between -inf + inf to restric per position AAs")
    argparser.add_argument("--pssm_log_odds_flag", type=int, default=0, help="0 for False, 1 for True")
    argparser.add_argument("--pssm_bias_flag", type=int, default=0, help="0 for False, 1 for True")
    
    argparser.add_argument("--tied_positions_jsonl", type=str, default='', help="Path to a dictionary with tied positions")
    
    args = argparser.parse_args()    
    main(args)   
