l2
SMART MODE:

NORMAL GENOMIC

SMART

Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922Nucleic Acids Res doi: 10.1093/nar/gkaa937

14_3_3

14-3-3 homologues
14_3_3
SMART accession number:SM00101
Description: 14-3-3 homologues mediates signal transduction by binding to phosphoserine-containing proteins. They are involved in growth factor signalling and also interact with MEK kinases.
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There are 6285 14_3_3 domains in 6269 proteins in SMART's nrdb database.

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4.1m

putative band 4.1 homologues' binding motif
4.1m
SMART accession number:SM00294
Description: -
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acidPPc

Acid phosphatase homologues
acidPPc
SMART accession number:SM00014
Description: -
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ADF

Actin depolymerisation factor/cofilin -like domains
ADF
SMART accession number:SM00102
Description: Severs actin filaments and binds to actin monomers.
GO function:actin binding (GO:0003779)
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ANK

ankyrin repeats
ANK
SMART accession number:SM00248
Description: Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
GO function:protein binding (GO:0005515)
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APCDDC

Adenomatosis polyposis coli down-regulated 1
APCDDC
SMART accession number:SM01352
Description: The domain is duplicated in most members of this family. APCDD is directly regulated by the beta-catenin/Tcf complex, and its elevated expression promotes proliferation of colonic epithelial cells in vitro and in vivo (PMID:12384519). APCDD1 has an N-terminal signal-peptide and a C-terminal transmembrane region. The domain is rich in cysteines, there being up to 12 such residues, a structural motif important for interaction between Wnt ligands and their receptors. APCDD1 is expressed in a broad repertoire of cell types, indicating that it may regulate a diverse range of biological processes controlled by Wnt signalling (PMID:20393562).
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ARF

ARF-like small GTPases; ARF, ADP-ribosylation factor
ARF
SMART accession number:SM00177
Description: Ras homologues involved in vesicular transport. Activator of phospholipase D isoforms. Unlike Ras proteins they lack cysteine residues at their C-termini and therefore are unlikely to be prenylated. ARFs are N-terminally myristoylated. Contains ATP/GTP-binding motif (P-loop).
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ArfGap

Putative GTP-ase activating proteins for the small GTPase, ARF
ArfGap
SMART accession number:SM00105
Description: Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.
GO function:GTPase activator activity (GO:0005096)
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ARM

Armadillo/beta-catenin-like repeats
ARM
SMART accession number:SM00185
Description: Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
GO function:protein binding (GO:0005515)
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B41

Band 4.1 homologues
B41
SMART accession number:SM00295
Description: Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.
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B561

Cytochrome b-561 / ferric reductase transmembrane domain.
B561
SMART accession number:SM00665
Description: Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.
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B_lectin

Bulb-type mannose-specific lectin
B_lectin
SMART accession number:SM00108
Description: -
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BAG

BAG domains, present in regulator of Hsp70 proteins
BAG
SMART accession number:SM00264
Description: BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains
GO function:chaperone binding (GO:0051087)
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BH4

BH4 Bcl-2 homology region 4
BH4
SMART accession number:SM00265
Description: -
GO process:regulation of apoptotic process (GO:0042981)
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BIR

Baculoviral inhibition of apoptosis protein repeat
BIR
SMART accession number:SM00238
Description: Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.
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BTK

Bruton's tyrosine kinase Cys-rich motif
BTK
SMART accession number:SM00107
Description: Zinc-binding motif containing conserved cysteines and a histidine. Always found C-terminal to PH domains (but not all PH domains are followed by BTK motifs). The crystal structure shows this motif packs against the PH domain. The PH+Btk module pair has been called the Tec homology (TH) region.
GO process:intracellular signal transduction (GO:0035556)
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C1

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
C1
SMART accession number:SM00109
Description: Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.
GO process:intracellular signal transduction (GO:0035556)
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C2

Protein kinase C conserved region 2 (CalB)
C2
SMART accession number:SM00239
Description: Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles.
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Calx_beta

Domains in Na-Ca exchangers and integrin-beta4
Calx_beta
SMART accession number:SM00237
Description: Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
GO process:cell communication (GO:0007154)
GO component:integral component of membrane (GO:0016021)
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CARD

Caspase recruitment domain
CARD
SMART accession number:SM00114
Description: Motif contained in proteins involved in apoptotic signalling. Mediates homodimerisation. Structure consists of six antiparallel helices arranged in a topology homologue to the DEATH and the DED domain.
GO process:regulation of apoptotic process (GO:0042981)
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CASc

Caspase, interleukin-1 beta converting enzyme (ICE) homologues
CASc
SMART accession number:SM00115
Description: Cysteine aspartases that mediate programmed cell death (apoptosis). Caspases are synthesised as zymogens and activated by proteolysis of the peptide backbone adjacent to an aspartate. The resulting two subunits associate to form an (alpha)2(beta)2-tetramer which is the active enzyme. Activation of caspases can be mediated by other caspase homologues.
GO function:cysteine-type peptidase activity (GO:0008234)
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CH

Calponin homology domain
CH
SMART accession number:SM00033
Description: Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.
GO function:protein binding (GO:0005515)
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CheW

Two component signalling adaptor domain
CheW
SMART accession number:SM00260
Description: -
GO process:signal transduction (GO:0007165), chemotaxis (GO:0006935)
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CNH

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
CNH
SMART accession number:SM00036
Description: Unpublished observations.
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cNMP

Cyclic nucleotide-monophosphate binding domain
cNMP
SMART accession number:SM00100
Description: Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.
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CULLIN

Cullin
CULLIN
SMART accession number:SM00182
Description: -
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CYCc

Adenylyl- / guanylyl cyclase, catalytic domain
CYCc
SMART accession number:SM00044
Description: Present in two copies in mammalian adenylyl cyclases. Eubacterial homologues are known. Two residues (Asn, Arg) are thought to be involved in catalysis. These cyclases have important roles in a diverse range of cellular processes.
GO process:cyclic nucleotide biosynthetic process (GO:0009190), intracellular signal transduction (GO:0035556)
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Cyclin_C

Cyclin_C
SMART accession number:SM01332
Description: Cyclins are a family of proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinase (Cdk) enzymes.
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Cyt-b5

Cytochrome b5-like Heme/Steroid binding domain
Cyt-b5
SMART accession number:SM01117
Description: This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors such as O00264 ((PUBMED:9705155),(PUBMED:8774719)). Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.
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DAGKa

Diacylglycerol kinase accessory domain (presumed)
DAGKa
SMART accession number:SM00045
Description: Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain might either be an accessory domain or else contribute to the catalytic domain. Bacterial homologues are known.
GO process:protein kinase C-activating G protein-coupled receptor signaling pathway (GO:0007205)
GO function:diacylglycerol kinase activity (GO:0004143)
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