l2
SMART MODE:

NORMAL GENOMIC

SMART

Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922Nucleic Acids Res doi: 10.1093/nar/gkaa937

There are 6285 14_3_3 domains in 6269 proteins in SMART's nrdb database.

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DAX

Domain present in Dishevelled and axin
DAX
SMART accession number:SM00021
Description: Domain of unknown function.
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DEATH

DEATH domain, found in proteins involved in cell death (apoptosis).
DEATH
SMART accession number:SM00005
Description: Alpha-helical domain present in a variety of proteins with apoptotic functions. Some (but not all) of these domains form homotypic and heterotypic dimers.
GO process:signal transduction (GO:0007165)
GO function:protein binding (GO:0005515)
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DED

Death effector domain
DED
SMART accession number:SM00031
Description: -
GO process:regulation of apoptotic process (GO:0042981)
GO function:protein binding (GO:0005515)
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DEP

Domain found in Dishevelled, Egl-10, and Pleckstrin
DEP
SMART accession number:SM00049
Description: Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).
GO process:intracellular signal transduction (GO:0035556)
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DSPc

Dual specificity phosphatase, catalytic domain
DSPc
SMART accession number:SM00195
Description: -
GO process:protein dephosphorylation (GO:0006470)
GO function:protein tyrosine/serine/threonine phosphatase activity (GO:0008138)
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DYNc

Dynamin, GTPase
DYNc
SMART accession number:SM00053
Description: Large GTPases that mediate vesicle trafficking. Dynamin participates in the endocytic uptake of receptors, associated ligands, and plasma membrane following an exocytic event.
GO function:GTPase activity (GO:0003924), GTP binding (GO:0005525)
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EAL

Putative diguanylate phosphodiesterase
EAL
SMART accession number:SM00052
Description: Putative diguanylate phosphodiesterase, present in a variety of bacteria.
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EFh

EF-hand, calcium binding motif
EFh
SMART accession number:SM00054
Description: EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions.
GO function:calcium ion binding (GO:0005509)
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EH

Eps15 homology domain
EH
SMART accession number:SM00027
Description: Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.
GO function:protein binding (GO:0005515)
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ENTH

Epsin N-terminal homology (ENTH) domain
ENTH
SMART accession number:SM00273
Description: -
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FBOX

A Receptor for Ubiquitination Targets
FBOX
SMART accession number:SM00256
Description: -
GO function:protein binding (GO:0005515)
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FCH

Fes/CIP4 homology domain
FCH
SMART accession number:SM00055
Description: Alignment extended from original report. Highly alpha-helical. Also known as the RAEYL motif or the S. pombe Cdc15 N-terminal domain.
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FF

Contains two conserved F residues
FF
SMART accession number:SM00441
Description: A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.
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FH2

Formin Homology 2 Domain
FH2
SMART accession number:SM00498
Description: FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.
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FHA

Forkhead associated domain
FHA
SMART accession number:SM00240
Description: Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.
GO function:protein binding (GO:0005515)
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FIST

FIST N domain
FIST
SMART accession number:SM00897
Description: The FIST N domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids.
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Frizzled

Frizzled/Smoothened family membrane region
Frizzled
SMART accession number:SM01330
Description: Frizzled is a family of G protein-coupled receptor proteins (PMID: 14977528) that serves as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol.
GO process:cell surface receptor signaling pathway (GO:0007166)
GO component:membrane (GO:0016020)
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FYVE

Protein present in Fab1, YOTB, Vac1, and EEA1
FYVE
SMART accession number:SM00064
Description: The FYVE zinc finger is named after four proteins where it was first found: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn2+ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. The FYVE finger is structurally related to the PHD finger and the RING finger. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. The FYVE finger functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is prominent on endosomes. The R+HHC+XCG motif is critical for PI3P binding.
GO function:metal ion binding (GO:0046872)
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G_alpha

G protein alpha subunit
G_alpha
SMART accession number:SM00275
Description: Subunit of G proteins that contains the guanine nucleotide binding site
GO process:G protein-coupled receptor signaling pathway (GO:0007186)
GO function:GTPase activity (GO:0003924), guanyl nucleotide binding (GO:0019001), G-protein beta/gamma-subunit complex binding (GO:0031683)
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GAF

Domain present in phytochromes and cGMP-specific phosphodiesterases.
GAF
SMART accession number:SM00065
Description: Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.
GO function:protein binding (GO:0005515)
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GAS2

Growth-Arrest-Specific Protein 2 Domain
GAS2
SMART accession number:SM00243
Description: GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
GO function:microtubule binding (GO:0008017)
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GED

Dynamin GTPase effector domain
GED
SMART accession number:SM00302
Description: -
GO function:GTPase activity (GO:0003924), GTP binding (GO:0005525)
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GGDEF

diguanylate cyclase
GGDEF
SMART accession number:SM00267
Description: Diguanylate cyclase, present in a variety of bacteria.
Family alignment:
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GGL

G protein gamma subunit-like motifs
GGL
SMART accession number:SM00224
Description: -
GO process:G protein-coupled receptor signaling pathway (GO:0007186)
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GoLoco

LGN motif, putative GEFs specific for G-alpha GTPases
GoLoco
SMART accession number:SM00390
Description: GEF specific for Galpha_i proteins
GO function:GTPase regulator activity (GO:0030695)
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GRAM

domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins
GRAM
SMART accession number:SM00568
Description: -
Family alignment:
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GS

GS motif
GS
SMART accession number:SM00467
Description: Aa approx. 30 amino acid motif that precedes the kinase domain in types I and II TGF beta receptors. Mutation of two or more of the serines or threonines in the TTSGSGSG of TGF-beta type I receptor impairs phosphorylation and signaling activity.
GO process:protein phosphorylation (GO:0006468)
GO component:membrane (GO:0016020)
GO function:ATP binding (GO:0005524), transmembrane receptor protein serine/threonine kinase activity (GO:0004675)
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GuKc

Guanylate kinase homologues.
GuKc
SMART accession number:SM00072
Description: Active enzymes catalyze ATP-dependent phosphorylation of GMP to GDP. Structure resembles that of adenylate kinase. So-called membrane-associated guanylate kinase homologues (MAGUKs) do not possess guanylate kinase activities; instead at least some possess protein-binding functions.
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HAMP

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain
HAMP
SMART accession number:SM00304
Description: -
GO process:signal transduction (GO:0007165)
GO component:integral component of membrane (GO:0016021)
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HATPase_c

Histidine kinase-like ATPases
HATPase_c
SMART accession number:SM00387
Description: Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
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HECTc

Domain Homologous to E6-AP Carboxyl Terminus with
HECTc
SMART accession number:SM00119
Description: E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
GO function:ubiquitin-protein transferase activity (GO:0004842)
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HisKA

His Kinase A (phosphoacceptor) domain
HisKA
SMART accession number:SM00388
Description: Dimerisation and phosphoacceptor domain of histidine kinases.
GO process:signal transduction (GO:0007165)
GO function:phosphorelay sensor kinase activity (GO:0000155)
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HPT

Histidine Phosphotransfer domain
HPT
SMART accession number:SM00073
Description: Contains an active histidine residue that mediates phosphotransfer reactions. Domain detected only in eubacteria. This alignment is an extension to that shown in the Cell structure paper.
GO process:phosphorelay signal transduction system (GO:0000160)
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Hr1

Rho effector or protein kinase C-related kinase homology region 1 homologues
Hr1
SMART accession number:SM00742
Description: Alpha-helical domain found in vertebrate PRK1 and yeast PKC1 protein kinases C. The HR1 in rhophilin bind RhoGTP; those in PRK1 bind RhoA and RhoB. Also called RBD - Rho-binding domain
GO process:signal transduction (GO:0007165)
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ILWEQ

I/LWEQ domain
ILWEQ
SMART accession number:SM00307
Description: Thought to possess an F-actin binding function.
GO function:actin binding (GO:0003779)
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