"Molecule ChEMBL ID";"Molecule Name";"Molecule Max Phase";"Molecular Weight";"#RO5 Violations";"AlogP";"Compound Key";"Smiles";"Standard Type";"Standard Relation";"Standard Value";"Standard Units";"pChEMBL Value";"Data Validity Comment";"Comment";"Uo Units";"Ligand Efficiency BEI";"Ligand Efficiency LE";"Ligand Efficiency LLE";"Ligand Efficiency SEI";"Potential Duplicate";"Assay ChEMBL ID";"Assay Description";"Assay Type";"BAO Format ID";"BAO Label";"Assay Organism";"Assay Tissue ChEMBL ID";"Assay Tissue Name";"Assay Cell Type";"Assay Subcellular Fraction";"Target ChEMBL ID";"Target Name";"Target Organism";"Target Type";"Document ChEMBL ID";"Source ID";"Source Description";"Document Journal";"Document Year";"Cell ChEMBL ID"
"CHEMBL242255";"";"0";"276.42";"0";"3.59";"ACU";"O=C(NC1CCCCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"31.82";"0.60";"5.21";"21.39";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL217758";"";"0";"373.42";"0";"2.81";"TPAU";"O=C(NC1CCN(C(=O)C(F)(F)F)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"23.99";"0.47";"6.15";"14.58";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"21.71";"0.42";"3.28";"10.87";"True";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL242655";"";"0";"396.57";"0";"3.49";"AEPU";"CCOCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"19.80";"0.38";"4.36";"11.41";"True";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933492";"";"0";"350.91";"0";"2.11";"14-1";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)CCCl)CC1";"IC50";"'='";"340.0";"nM";"6.47";"";"";"UO_0000065";"18.43";"0.40";"4.36";"9.73";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1705444";"";"0";"364.51";"0";"2.93";"14-6";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccccc2)CC1";"IC50";"'='";"510.0";"nM";"6.29";"";"";"UO_0000065";"17.26";"0.34";"3.36";"9.47";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933512";"";"0";"442.60";"0";"2.33";"14-22";"CS(=O)(=O)c1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"13000.0";"nM";"4.89";"";"";"UO_0000065";"11.04";"0.23";"2.56";"4.86";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933514";"";"0";"406.59";"0";"4.05";"14-26";"CC(C)c1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"470.0";"nM";"6.33";"";"";"UO_0000065";"15.56";"0.31";"2.28";"9.52";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933672";"";"0";"328.46";"0";"3.38";"15-4";"O=C(NC1CCCCCC1)C1CCN(C(=O)c2ccccc2)CC1";"IC50";"'='";"630.0";"nM";"6.20";"";"";"UO_0000065";"18.88";"0.35";"2.82";"12.55";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933675";"";"0";"346.45";"0";"3.52";"15-8";"O=C(NC1CCCCCC1)C1CCN(C(=O)c2cccc(F)c2)CC1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"17.09";"0.32";"2.40";"11.98";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933677";"";"0";"353.47";"0";"3.25";"15-11";"N#Cc1ccc(C(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"2000.0";"nM";"5.70";"";"";"UO_0000065";"16.12";"0.30";"2.45";"7.79";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1890196";"";"0";"407.35";"0";"4.14";"15-12";"O=C(NC1CCCCCC1)C1CCN(C(=O)c2ccc(Br)cc2)CC1";"IC50";"'='";"590.0";"nM";"6.23";"";"";"UO_0000065";"15.29";"0.34";"2.09";"12.61";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL3263297";"";"0";"554.86";"2";"7.14";"3b";"CC(NC(=O)NCCCCCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"Ki";"'='";"3.1";"nM";"8.51";"";"";"UO_0000065";"15.33";"0.29";"1.37";"10.34";"False";"CHEMBL3270577";"Displacement of ACPU from recombinant human soluble epoxide hydrolase after 1.5 hrs by FRET assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL585949";"";"0";"436.84";"0";"3.40";"35";"CS(=O)(=O)c1cc(Cl)ccc1CNC(=O)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"66.0";"nM";"7.18";"";"";"UO_0000065";"16.44";"0.35";"3.78";"8.41";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL69744";"";"0";"327.81";"0";"3.38";"13";"CCCCCNC(=O)OCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"18000.0";"nM";"4.75";"";"";"UO_0000065";"14.47";"0.29";"1.36";"5.97";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL562440";"";"0";"354.54";"0";"4.97";"3";"CCCCCN(C)C(=O)NCCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"1451.0";"nM";"5.84";"";"";"UO_0000065";"16.47";"0.32";"0.87";"8.38";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL559573";"";"0";"340.51";"0";"4.63";"8";"CCCCCNC(=O)NCCCC/C=C/CCCCCCC(=O)O";"IC50";"'='";"48.5";"nM";"7.31";"";"";"UO_0000065";"21.48";"0.42";"2.68";"9.33";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL550551";"";"0";"353.55";"1";"5.57";"23";"CCCCCCN(C)C(=O)CCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"13877.0";"nM";"4.86";"";"";"UO_0000065";"13.74";"0.27";"-0.71";"8.43";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL564227";"";"0";"436.51";"0";"4.05";"(R)-24";"CS(=O)(=O)c1ccc([C@H](CCNC(=O)c2ccc(C#N)cc2)c2ccc(F)cc2)cc1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"17.99";"0.35";"3.80";"9.02";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL556234";"";"0";"510.51";"1";"4.52";"23";"CS(=O)(=O)c1ccc(C(CCNC(=O)c2ccc(OCC(F)(F)F)nc2)c2ccc(F)cc2)cc1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"16.45";"0.33";"3.88";"9.84";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL592207";"";"0";"332.28";"0";"2.91";"9";"O=C(O)C1CCN(C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'>'";"3000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL308665";"";"0";"394.51";"0";"2.92";"31";"CCOC(=O)CCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC90";"'='";"5000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677486";"Tested for 90 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL1079362";"";"0";"295.39";"0";"3.67";"1c";"CC1(c2ccccc2)CCCN(C(=O)Nc2ccncc2)C1";"IC50";"'='";"550.0";"nM";"6.26";"";"";"UO_0000065";"21.19";"0.39";"2.59";"13.84";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1077780";"";"0";"334.46";"0";"4.31";"1n";"CC1(c2ccccc2)CCCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL562822";"";"0";"389.46";"0";"3.58";"entA-2d";"O=C(N[C@@H]1C[C@H]1c1ccccc1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"20.17";"0.37";"4.27";"9.33";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL2392692";"";"0";"503.32";"1";"3.42";"27, GSK2188931B";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(Br)cc3OC(F)(F)F)CC2)n1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"18.48";"0.41";"5.88";"10.08";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392706";"";"0";"424.43";"0";"2.65";"18";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3OC(F)(F)F)CC2)n1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"21.20";"0.41";"6.35";"9.75";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392705";"";"0";"405.46";"0";"4.59";"17";"CNc1cc(C)cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)c1";"IC50";"'='";"32.0";"nM";"7.50";"";"";"UO_0000065";"18.48";"0.35";"2.90";"16.89";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392698";"";"0";"452.48";"0";"2.79";"10h";"COCCNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.89";"0.38";"6.21";"9.75";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392714";"";"0";"408.43";"0";"2.77";"10a";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"20.87";"0.40";"5.75";"10.26";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2032044";"";"0";"474.61";"0";"4.87";"140";"O=C(Nc1cccc(C(=O)Nc2ccc(N3CCOCC3)cc2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"74.2";"nM";"7.13";"";"";"UO_0000065";"15.02";"0.28";"2.26";"8.62";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL512871";"";"0";"400.54";"0";"3.33";"8-9";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccccc3)CC2)c(C)c1";"IC50";"'='";"42.0";"nM";"7.38";"";"";"UO_0000065";"18.42";"0.36";"4.05";"11.10";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470604";"";"0";"455.41";"0";"4.33";"6-25";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C)c1";"Inhibition";"'='";"97.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469371";"";"0";"395.53";"0";"1.38";"8-49";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NN3CCOCC3)CC2)c(C)c1";"Inhibition";"'='";"14.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469554";"";"0";"393.34";"0";"3.06";"6-15";"CC(C)S(=O)(=O)N1CCC(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469338";"";"0";"495.35";"0";"4.73";"6-16";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccccc2C(F)(F)F)CC1";"Inhibition";"'='";"39.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL511448";"";"0";"401.53";"0";"3.16";"8-22";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NNc3ccccc3)CC2)c(C)c1";"Inhibition";"'='";"16.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470837";"";"0";"378.54";"0";"3.07";"8-48";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCC3)CC2)c(C)c1";"Inhibition";"'='";"75.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL557509";"";"0";"388.90";"0";"3.62";"14l";"O=C(Cc1ccc(Cl)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"116.0";"nM";"6.94";"";"";"UO_0000065";"17.83";"0.35";"3.32";"13.65";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL550655";"";"0";"407.87";"0";"4.22";"13l";"O=C(Nc1ccc(Cl)cc1)Nc1ccc(F)c(OCCCN2CCOCC2)c1";"IC50";"'='";"4.8";"nM";"8.32";"";"";"UO_0000065";"20.40";"0.41";"4.10";"13.24";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL563709";"";"0";"419.61";"0";"3.30";"25c";"O=C(NC1CCCC(OCCCN2CCOCC2)C1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.5";"nM";"8.60";"";"";"UO_0000065";"20.50";"0.39";"5.30";"13.69";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL561382";"";"0";"355.44";"0";"3.43";"19d";"O=C(Nc1ccccc1)Nc1ccc(OCCCN2CCOCC2)cc1";"IC50";"'='";"39.0";"nM";"7.41";"";"";"UO_0000065";"20.84";"0.39";"3.98";"11.79";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1933503";"";"0";"420.62";"0";"4.22";"14-13";"CC(C)(C)c1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"62.0";"nM";"7.21";"";"";"UO_0000065";"17.14";"0.34";"2.99";"10.84";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933509";"";"0";"409.51";"0";"2.83";"14-19";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)CC1";"IC50";"'='";"50000.0";"nM";"4.30";"";"";"UO_0000065";"10.50";"0.21";"1.47";"3.92";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933497";"";"0";"443.41";"0";"3.69";"14-7";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccccc2Br)CC1";"IC50";"'='";"6.7";"nM";"8.17";"";"";"UO_0000065";"18.43";"0.43";"4.48";"12.30";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933500";"";"0";"409.51";"0";"2.83";"14-10";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"19.34";"0.39";"5.09";"7.23";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933506";"";"0";"432.51";"0";"3.95";"14-16";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1";"IC50";"'='";"2100.0";"nM";"5.68";"";"";"UO_0000065";"13.13";"0.27";"1.73";"8.54";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1818387";"";"0";"288.31";"0";"4.20";"4";"CCCCCCCNC(=O)Nc1ccc(F)c(F)c1F";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"32.60";"0.64";"5.20";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL2031941";"";"0";"410.60";"0";"3.88";"99";"CCOCCOCCOCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"21.73";"0.42";"5.04";"12.96";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1257880";"";"0";"536.58";"1";"4.78";"59";"CN(C)c1cccc2c(S(=O)(=O)N3CCC(NC(=O)Nc4ccc(OC(F)(F)F)cc4)CC3)cccc12";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"16.95";"0.34";"4.32";"10.00";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257634";"";"0";"381.38";"0";"2.13";"55";"CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"2.9";"nM";"8.54";"";"";"UO_0000065";"22.39";"0.47";"6.41";"9.73";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258904";"";"0";"359.35";"0";"3.11";"40";"CCC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"3.7";"nM";"8.43";"";"";"UO_0000065";"23.46";"0.46";"5.32";"11.93";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1256164";"";"0";"281.40";"0";"2.02";"4";"CCC(=O)N1CCC(NC(=O)NC2CCCCC2)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"28.15";"0.54";"5.90";"12.89";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258448";"";"0";"293.34";"0";"2.35";"29";"CCC(=O)N1CCC(NC(=O)Nc2ccccc2F)CC1";"IC50";"'='";"300.0";"nM";"6.52";"";"";"UO_0000065";"22.24";"0.42";"4.17";"10.62";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258220";"";"0";"291.35";"0";"1.91";"23";"CCC(=O)N1CCC(NC(=O)Nc2ccc(O)cc2)CC1";"IC50";"'='";"406.0";"nM";"6.39";"";"";"UO_0000065";"21.94";"0.42";"4.48";"7.83";"False";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL376647";"";"0";"418.53";"1";"5.06";"2{1}";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2c(F)cccc2F)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"22.22";"0.42";"4.24";"18.47";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL221015";"";"0";"396.38";"1";"5.36";"1{16}";"O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"82.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3222124";"";"0";"545.73";"1";"3.10";"6c";"CC(C)(C)OC(=O)N1CCN(C(=O)CCC(=O)N2CCC(NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)CC1";"IC50";"'='";"18.8";"nM";"7.73";"";"";"UO_0000065";"14.16";"0.27";"4.63";"6.94";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL572182";"";"0";"292.26";"0";"4.46";"7d";"FC(F)(F)c1ccc(CNc2noc3ccccc23)cc1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"20.26";"0.39";"1.46";"15.56";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL566038";"";"0";"413.57";"0";"4.67";"11";"O=C(NCCC(c1ccccc1)c1ccccc1)c1ccc(CCN2CCCC2)nc1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"18.73";"0.34";"3.07";"17.12";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1088565";"";"0";"382.51";"0";"2.82";"4a";"O=C(Nc1ccc(C(=O)N2CCNCC2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"67.1";"nM";"7.17";"";"";"UO_0000065";"18.75";"0.35";"4.35";"9.76";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3633682";"";"0";"317.43";"0";"3.53";"4d";"Cc1cc(CNC(=O)NC23CC4CC(C)(CC(C)(C4)C2)C3)on1";"IC50";"'='";"123.0";"nM";"6.91";"";"";"UO_0000065";"21.77";"0.41";"3.38";"10.29";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL1668928";"";"0";"281.40";"0";"2.02";"14g";"CC(=O)N1CCC(NC(=O)NC2CCCCCC2)CC1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"32.33";"0.62";"7.08";"14.81";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668930";"";"0";"295.43";"0";"2.27";"14i";"CC(=O)N1CCC(NC(=O)NC2CCC(C)(C)CC2)CC1";"IC50";"'='";"6.0";"nM";"8.22";"";"";"UO_0000065";"27.83";"0.53";"5.95";"13.38";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668940";"";"0";"409.43";"0";"2.91";"14s";"CC(C)S(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"64.0";"nM";"7.19";"";"";"UO_0000065";"17.57";"0.36";"4.28";"8.20";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL3114597";"";"0";"404.43";"0";"4.81";"19";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccc(C(F)(F)F)cc2)CC1";"IC50";"'='";"29.8";"nM";"7.53";"";"";"UO_0000065";"18.61";"0.35";"2.72";"18.10";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL2436576";"";"0";"487.48";"0";"4.62";"24";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3cccc4[nH]cnc34)CC2)C1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"18.66";"0.35";"4.48";"10.05";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL4089062";"";"0";"358.40";"0";"3.45";"27";"CCCN1CCC(C(=O)NCc2ccc(OC)cc2C(F)(F)F)CC1";"IC50";"'='";"190.0";"nM";"6.72";"";"";"UO_0000065";"18.75";"0.37";"3.27";"16.17";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL3322818";"";"0";"400.59";"0";"4.05";"BDBM50057625";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC1=NOS(=O)N1";"IC50";"'='";"10.0";"nM";"8.00";"";"326398";"UO_0000065";"19.97";"0.40";"3.95";"8.71";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322814";"";"0";"364.54";"0";"3.91";"BDBM50057494";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1nnn[nH]1";"IC50";"'='";"11.0";"nM";"7.96";"";"326408";"UO_0000065";"21.83";"0.42";"4.05";"8.33";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4107289";"";"0";"492.33";"None";"None";"BDBM179764";"";"IC50";"'>'";"500.0";"nM";"";"";"326410";"UO_0000065";"";"";"";"";"False";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL250872";"SYRINGIN";"0";"372.37";"0";"-1.11";"5";"COc1cc(/C=C/CO)cc(OC)c1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O";"Inhibition";"'<'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1933667";"";"0";"414.55";"0";"2.69";"14-50";"O=C(O)c1csc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c1";"IC50";"'='";"6000.0";"nM";"5.22";"";"";"UO_0000065";"12.60";"0.26";"2.53";"5.03";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL2180634";"";"0";"433.39";"0";"4.45";"6g";"O=C(NCc1ccccc1Cn1cccc1C(=O)O)Nc1ccc(OC(F)(F)F)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL2031795";"";"0";"426.56";"0";"4.43";"129";"COC(=O)c1cccc(O[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c1";"IC50";"'='";"2.5";"nM";"8.60";"";"";"UO_0000065";"20.17";"0.38";"4.17";"11.22";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL69663";"";"0";"334.55";"1";"5.40";"4";"CCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"20.80";"0.40";"1.56";"16.92";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL192293";"";"0";"252.74";"0";"3.79";"b-1";"O=C(Nc1cccc(Cl)c1)NC1CCCCC1";"IC50";"'='";"190.0";"nM";"6.72";"";"";"UO_0000065";"26.59";"0.54";"2.93";"16.34";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL2180624";"";"0";"435.57";"0";"4.48";"5f";"CCOC(=O)c1cccn1Cc1ccc(CNC(=O)NC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)cc1";"IC50";"'='";"87.0";"nM";"7.06";"";"";"UO_0000065";"16.21";"0.30";"2.58";"9.76";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL222161";"";"0";"386.42";"0";"4.12";"9";"COC(=O)c1cccc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc(F)cc3)CC2)c1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"22.51";"0.42";"4.58";"11.35";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL374730";"";"0";"362.83";"0";"4.99";"1{13}";"O=C(Nc1ccc(Cl)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"81.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL224266";"";"0";"708.98";"2";"3.92";"20";"CCCCCCCC(NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"9.87";"0.19";"3.08";"3.69";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL438838";"";"0";"531.76";"2";"5.66";"19";"O=C(CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1ccccc1";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"13.16";"0.26";"1.34";"6.71";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL223281";"";"0";"448.69";"1";"6.50";"8";"CCCCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"15.60";"0.30";"0.50";"10.38";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL375240";"";"0";"432.65";"1";"5.88";"5";"C=CCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"16.18";"0.31";"1.12";"10.38";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL427070";"";"0";"434.67";"1";"6.11";"7";"CC(C)OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"20.61";"0.39";"2.85";"13.29";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL223900";"";"0";"420.64";"1";"5.72";"3";"CCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"20.91";"0.40";"3.08";"13.04";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"10.3";"nM";"7.99";"";"";"UO_0000065";"20.35";"0.39";"2.75";"10.18";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1313977";"";"0";"247.34";"0";"2.76";"r";"O=C(NCCOc1ccccc1)C1CCCCC1";"Activity";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3102106";"Binding affinity to soluble epoxide hydrolase (unknown origin) at 400 uM by STD-NMR assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL66499";"";"0";"228.34";"0";"1.78";"7";"O=C(NCCCCCO)NC1CCCCC1";"IC50";"'='";"253000.0";"nM";"";"Outside typical range";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL3634700";"";"0";"556.52";"3";"-1.94";"13";"COc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(OC)c(C(C)=O)c(O[C@H]3OC[C@@](O)(CO)[C@@H]3O)cc2c1";"IC50";"'='";"2200.0";"nM";"5.66";"";"";"UO_0000065";"10.17";"0.20";"7.60";"2.64";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL2180632";"";"0";"407.51";"0";"4.00";"6e";"O=C(NCc1cccc(Cn2cccc2C(=O)O)c1)NC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3";"IC50";"'='";"304.0";"nM";"6.52";"";"";"UO_0000065";"15.99";"0.30";"2.52";"7.82";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL3818601";"";"0";"362.81";"0";"3.56";"3d";"CC(Oc1ccc(CCNC(=O)Nc2ccc(Cl)cc2)cc1)C(=O)O";"IC50";"'='";"570.0";"nM";"6.24";"";"";"UO_0000065";"17.21";"0.34";"2.68";"7.12";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL3818537";"";"0";"490.57";"1";"5.37";"5b";"CCOC(=O)C(CC)Cc1ccc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)cc1";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"15.57";"0.30";"2.27";"13.03";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL3824048";"";"0";"444.31";"1";"6.71";"8j";"CCC(=O)Nc1cc(Cl)c(Oc2ccc(O)c(-c3ccc(C(C)=O)cc3)c2)c(Cl)c1";"IC50";"'='";"7700.0";"nM";"5.11";"";"";"UO_0000065";"11.51";"0.23";"-1.60";"6.76";"False";"CHEMBL3825936";"Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured after 10 mins by liquid scintillation counter method";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"BTI-TN-5B1-4";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3822419";"1";"Scientific Literature";"J. Med. Chem.";"2016";"CHEMBL3833782"
"CHEMBL1458";"1,3-DICYCLOHEXYLUREA";"0";"224.35";"0";"2.95";"DCU";"O=C(NC1CCCCC1)NC1CCCCC1";"IC50";"'='";"52.0";"nM";"7.28";"";"";"UO_0000065";"32.47";"0.62";"4.33";"17.71";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933515";"";"0";"461.40";"0";"3.83";"14-27";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2Br)CC1";"IC50";"'='";"5.4";"nM";"8.27";"";"";"UO_0000065";"17.92";"0.42";"4.44";"12.44";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933516";"";"0";"450.50";"0";"4.08";"14-28";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2C(F)(F)F)CC1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"17.37";"0.36";"3.74";"11.77";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL589136";"";"0";"381.26";"0";"3.54";"1, Table1";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ncccn2)CC1";"IC50";"'='";"63.0";"nM";"7.20";"";"";"UO_0000065";"18.89";"0.39";"3.66";"10.69";"False";"CHEMBL1118602";"Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL550692";"";"0";"368.56";"1";"5.31";"4";"CCCCCN(C)C(=O)N(C)CCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"8484.0";"nM";"5.07";"";"";"UO_0000065";"13.76";"0.27";"-0.24";"8.33";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL562441";"";"0";"341.49";"1";"5.05";"6";"CCCCCOC(=O)NCCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"2834.0";"nM";"5.55";"";"";"UO_0000065";"16.25";"0.32";"0.50";"7.34";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL558485";"";"0";"341.49";"1";"5.05";"7";"CCCCCNC(=O)OCCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"3480.0";"nM";"5.46";"";"";"UO_0000065";"15.98";"0.31";"0.41";"7.22";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL551899";"";"0";"284.40";"0";"3.07";"27";"CCCCCNC(=O)NCCCC/C=C\CCC(=O)O";"IC50";"'='";"1355.0";"nM";"5.87";"";"";"UO_0000065";"20.63";"0.40";"2.80";"7.48";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"21.71";"0.42";"3.28";"10.87";"True";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL3327086";"";"0";"407.46";"0";"3.42";"31";"CCCCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"T1/2";"'='";"0.1833";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327081";"";"0";"497.33";"1";"5.04";"24";"O=C(Nc1ccc(C(F)(C(F)(F)F)C(F)(F)F)cc1)NC1CCN(C(=O)CC(F)(F)F)CC1";"T1/2";"'='";"0.4417";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL2032041";"";"0";"355.48";"0";"3.61";"135";"O=C(Nc1ccc(N2CCOCC2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"5.2";"nM";"8.28";"";"";"UO_0000065";"23.30";"0.44";"4.67";"15.46";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL515028";"";"0";"383.49";"0";"3.25";"137";"O=C(Nc1cccc(C(=O)N2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"24.6";"nM";"7.61";"";"";"UO_0000065";"19.84";"0.37";"4.36";"10.77";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL4091712";"";"0";"339.31";"0";"3.65";"11";"COc1ccc(C(=O)NCc2ccc(OC)cc2C(F)(F)F)cc1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"26.52";"0.51";"5.35";"18.92";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL2031950";"";"0";"396.53";"0";"4.42";"114";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OC(=O)c2ccccc2)CC1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"22.70";"0.42";"4.58";"13.35";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL11293";"";"0";"158.24";"0";"1.50";"20";"CCCCCCNC(=O)NC";"IC50";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL810460";"Inhibitory activity against human soluble epoxide hydrolase; N/A = could not be determined because of above the highest concentration (500 uM) of inhibitor tested.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1136721";"1";"Scientific Literature";"J. Med. Chem.";"2003";"None"
"CHEMBL3617995";"";"0";"402.40";"1";"-0.08";"4";"Cc1cc(O)c2c(c1)[C@H]([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)c1cccc(O)c1C2=O";"Inhibition";"'='";"90.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3620668";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde at 100 uM measured during 1 hr by fluorescence photometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL2392688";"";"0";"340.43";"0";"1.75";"23";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3)CC2)n1";"IC50";"'='";"200.0";"nM";"6.70";"";"";"UO_0000065";"19.68";"0.37";"4.95";"8.07";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL192523";"";"0";"247.34";"0";"3.60";"c-2";"COc1ccc(NC(=O)CC2CCCCC2)cc1";"IC50";"'='";"6200.0";"nM";"5.21";"";"";"UO_0000065";"21.05";"0.40";"1.61";"13.59";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL221737";"";"0";"407.28";"1";"5.10";"1{14}";"O=C(Nc1ccc(Br)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"80.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3103807";"";"0";"342.44";"0";"2.52";"13";"CN(OCc1ccccc1)C(=O)C(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"3200.0";"nM";"5.50";"";"";"UO_0000065";"16.05";"0.30";"2.97";"9.37";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL2424982";"";"0";"438.55";"0";"4.00";"9f";"Cc1cc(C2CCN(C(=O)Nc3ccccc3)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"Inhibition";"'='";"89.89";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2425012";"";"0";"418.56";"0";"3.27";"9d";"CCCCNC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(C)(=O)=O)cc2)CC1";"Inhibition";"'='";"99.53";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2436579";"";"0";"478.47";"0";"4.61";"27";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3cnoc3C3CC3)CC2)C1";"IC50";"'='";"0.2";"nM";"9.70";"";"";"UO_0000065";"20.27";"0.39";"5.09";"11.03";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3322809";"";"0";"382.58";"0";"4.07";"14";"CCCCCNC(=O)NCCCC/C=C\CCCCCSc1nnn[nH]1";"IC50";"'='";"22.0";"nM";"7.66";"";"";"UO_0000065";"20.02";"0.40";"3.59";"8.01";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1096114";"";"0";"371.48";"0";"3.15";"5ab, meta isomer";"COCCNC(=O)c1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"18.73";"0.35";"3.81";"8.76";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088545";"";"0";"422.41";"0";"3.62";"5i,para isomer";"CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"19.31";"0.37";"4.53";"11.03";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1086693";"";"0";"386.43";"0";"2.53";"5p,para isomer";"O=C(Nc1ccc(F)cc1)Nc1ccc(C(=O)NCCN2CCOCC2)cc1";"IC50";"'='";"140.0";"nM";"6.85";"";"";"UO_0000065";"17.74";"0.33";"4.32";"8.29";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL3236507";"";"0";"430.45";"0";"-1.09";"6";"COC/C=C/c1ccc(O[C@@H](CO)CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(OC)c1";"Inhibition";"'<'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1088118";"";"0";"385.46";"0";"2.93";"5b, meta isomer";"CN(CC(=O)O)C(=O)c1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"230.0";"nM";"6.64";"";"";"UO_0000065";"17.22";"0.32";"3.71";"6.72";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1097179";"";"0";"406.41";"0";"3.74";"5h, meta isomer";"CN1CCN(C(=O)c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"19.49";"0.37";"4.18";"12.25";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL589621";"";"0";"413.73";"1";"5.40";"37";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccc(Cl)cc2)CC1";"IC50";"'='";"5.9";"nM";"8.23";"";"";"UO_0000065";"19.89";"0.43";"2.83";"19.80";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL592024";"";"0";"388.30";"0";"2.68";"23";"COCCNC(=O)C1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"'='";"210.0";"nM";"6.68";"";"";"UO_0000065";"17.20";"0.36";"4.00";"9.45";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1079256";"";"0";"386.88";"0";"4.77";"entA-2b";"O=C(O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"21.46";"0.42";"3.53";"11.92";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1079244";"";"0";"412.93";"0";"3.61";"2k";"O=C(Nc1ccc(Cl)cc1)N1CCCC(CCC2=NNNN2)(c2ccccc2)C1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"20.10";"0.39";"4.69";"10.27";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078337";"";"0";"387.87";"0";"4.17";"3e";"O=C(O)CCC1(c2cccnc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"28.0";"nM";"7.55";"";"";"UO_0000065";"19.47";"0.38";"3.38";"9.15";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078336";"";"0";"387.87";"0";"4.17";"3d";"O=C(O)CCC1(c2ccncc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1095472";"";"0";"400.36";"0";"5.00";"5t, meta isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(C(=O)Nc2cccnc2)c1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"19.34";"0.36";"2.74";"9.32";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088564";"";"0";"411.36";"0";"3.96";"6g,para isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(C(=O)N2CCOCC2)c(F)c1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"21.15";"0.41";"4.74";"12.31";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088350";"";"0";"470.52";"0";"4.06";"9a, para isomer";"CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)cc2)CC1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"17.64";"0.35";"4.24";"10.15";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088084";"";"0";"403.50";"0";"2.83";"13a, para isomer";"O=C(Nc1ccccc1)Nc1ccc(S(=O)(=O)CCCN2CCOCC2)cc1";"IC50";"'='";"54.0";"nM";"7.27";"";"";"UO_0000065";"18.01";"0.35";"4.44";"8.28";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088366";"";"0";"429.42";"0";"3.37";"9c, meta isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(S(=O)(=O)N2CCOCC2)c1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"20.96";"0.42";"5.63";"10.26";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1079291";"";"0";"372.90";"0";"4.68";"2h";"O=C(Nc1ccc(Cl)cc1)N1CCCC(CCCO)(c2ccccc2)C1";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"23.83";"0.47";"4.21";"16.90";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2436581";"";"0";"437.42";"0";"4.34";"29";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3ccco3)CC2)C1";"IC50";"'='";"0.9";"nM";"9.05";"";"";"UO_0000065";"20.68";"0.40";"4.71";"12.06";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1079258";"";"0";"454.88";"1";"5.79";"3b";"O=C(O)CCC1(c2cccc(C(F)(F)F)c2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1080973";"";"0";"377.32";"1";"5.26";"1e";"CC1(c2ccccc2)CCCN(C(=O)NCc2ccc(Cl)cc2Cl)C1";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2313171";"";"0";"464.59";"1";"5.14";"7-33";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(Oc4ccccc4)cc3)CC2)c(C)c1";"IC50";"'='";"20.0";"nM";"7.70";"";"";"UO_0000065";"16.57";"0.32";"2.56";"10.17";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3617995";"";"0";"402.40";"1";"-0.08";"4";"Cc1cc(O)c2c(c1)[C@H]([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)c1cccc(O)c1C2=O";"Ki";"'='";"200.0";"nM";"6.70";"";"";"UO_0000065";"16.65";"0.32";"6.78";"4.54";"False";"CHEMBL3620671";"Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3617996";"";"0";"564.54";"3";"-2.04";"5";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@H]([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"Ki";"'='";"2000.0";"nM";"5.70";"";"";"UO_0000065";"10.09";"0.19";"7.74";"2.51";"False";"CHEMBL3620671";"Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3818218";"";"0";"575.10";"2";"6.65";"8b";"CCCCCCC(Sc1nc(Cl)cc(NCCCC(=O)NCc2ccccc2C(F)(F)F)n1)C(=O)OCC";"IC50";"'='";"1300.0";"nM";"5.89";"";"";"UO_0000065";"10.23";"0.21";"-0.76";"6.31";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL3617994";"";"0";"418.40";"1";"-0.89";"3";"O=C1c2c(O)cccc2[C@@H]([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cc(CO)cc(O)c21";"Inhibition";"'='";"62.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3620668";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde at 100 uM measured during 1 hr by fluorescence photometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3127858";"";"0";"448.59";"0";"3.22";"40";"O=C(N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1sc(OC2CCOCC2)nc1[C@H]1CCCO1";"IC50";"'>'";"33000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3130369";"Inhibition of sEH (unknown origin)";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3124933";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL592503";"";"0";"317.22";"0";"2.91";"16";"O=C(NCc1ccc(Cl)cc1Cl)N1CCCC(CO)C1";"IC50";"'='";"41.0";"nM";"7.39";"";"";"UO_0000065";"23.29";"0.50";"4.48";"14.05";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL565629";"";"0";"414.33";"0";"3.21";"24";"O=C(NC1CCOCC1)C1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"'='";"180.0";"nM";"6.75";"";"";"UO_0000065";"16.28";"0.34";"3.53";"9.54";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL495993";"";"0";"377.44";"0";"3.15";"ent-1j";"O=C1CC2(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)Oc2cccnc21";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"21.45";"0.39";"4.95";"11.32";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3327077";"";"0";"373.38";"0";"3.35";"19";"CC(C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"T1/2";"'='";"0.3133";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327085";"";"0";"433.37";"0";"3.18";"30";"O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(S(=O)(=O)CC(F)(F)F)CC1";"Ki";"'='";"1.79";"nM";"8.75";"";"";"UO_0000065";"20.18";"0.43";"5.57";"11.14";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL482637";"";"0";"454.59";"0";"3.91";"ent-1i";"CS(=O)(=O)c1ccc2c(c1)CCC1(CCCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"18.75";"0.36";"4.61";"11.26";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL524992";"";"0";"375.39";"0";"4.71";"2a";"O=C(c1ccc(C(F)(F)F)cc1)N1CCC2(CCc3ccccc3O2)CC1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"22.37";"0.42";"3.69";"28.43";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3322817";"";"0";"380.53";"0";"4.07";"22";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1noc(=O)[nH]1";"IC50";"'='";"65.0";"nM";"7.19";"";"";"UO_0000065";"18.89";"0.36";"3.12";"7.19";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL519336";"";"0";"440.57";"0";"3.52";"ent-1h";"CS(=O)(=O)c1ccc2c(c1)CCC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"19.35";"0.38";"5.00";"11.26";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2336298";"";"0";"595.67";"2";"7.67";"8p";"COc1ccc(-c2nc3ccc(C)cn3c2NC2CCCCC2)cc1OCCCNC(=O)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"38.0";"nM";"7.42";"";"";"UO_0000065";"12.46";"0.24";"-0.25";"8.34";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2336300";"";"0";"600.09";"2";"8.32";"8r";"Cc1ccc2nc(-c3ccc(OCCCNC(=O)Nc4ccc(C(F)(F)F)cc4)c(Cl)c3)c(NC3CCCCC3)n2c1";"IC50";"'='";"189.0";"nM";"6.72";"";"";"UO_0000065";"11.20";"0.22";"-1.60";"8.44";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL1933499";"";"0";"378.54";"0";"3.23";"14-9";"Cc1ccccc1S(=O)(=O)N1CCC(C(=O)NC2CCCCCC2)CC1";"IC50";"'='";"24.0";"nM";"7.62";"";"";"UO_0000065";"20.13";"0.40";"4.39";"11.46";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933655";"";"0";"423.54";"0";"3.14";"14-38";"Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N1CCC(C(=O)NC2CCCCCC2)CC1";"IC50";"'='";"32.0";"nM";"7.50";"";"";"UO_0000065";"17.70";"0.35";"4.35";"6.84";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL2424987";"";"0";"466.61";"0";"4.56";"9k";"CCc1ccccc1NC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(C)(=O)=O)cc2)CC1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2424985";"";"0";"473.00";"0";"4.65";"9i";"Cc1cc(C2CCN(C(=O)Nc3ccccc3Cl)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL3103821";"";"0";"428.53";"0";"2.44";"31";"CON(C)C(=O)C(=O)N(C)c1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"Ratio IC50";"'='";"3.0";"";"";"";"";"";"";"";"";"";"False";"CHEMBL3107381";"Ratio of AUDA IC50 to compound IC50 for recombinant human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3103798";"";"0";"328.41";"0";"2.32";"4";"O=C(NOCc1ccccc1)C(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL2348407";"";"0";"348.36";"0";"2.43";"3g";"CC(C)(C)OC(=O)N1CCCC1C(=O)Oc1cccc2oc(=O)[nH]c12";"Inhibition";"'='";"100.68";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348405";"";"0";"382.44";"0";"2.67";"3e";"CSCCC(NC(=O)OC(C)(C)C)C(=O)Oc1cccc2oc(=O)[nH]c12";"Inhibition";"'='";"99.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1933674";"";"0";"342.48";"0";"3.69";"15-7";"Cc1cccc(C(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c1";"IC50";"'='";"780.0";"nM";"6.11";"";"";"UO_0000065";"17.83";"0.33";"2.42";"12.36";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL438867";"";"0";"402.54";"0";"4.21";"110";"CCOCCOCCOc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"21.72";"0.41";"4.53";"12.71";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031794";"";"0";"437.51";"1";"5.06";"124";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(F)(F)F)cn2)CC1";"IC50";"'='";"4.8";"nM";"8.32";"";"";"UO_0000065";"19.01";"0.37";"3.26";"13.15";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL3322826";"";"0";"406.55";"0";"4.29";"31";"CCCCCNC(=O)NCCCCCOc1cccc2sc(NC(C)=O)nc12";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327084";"";"0";"391.42";"0";"2.78";"28";"O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(S(=O)(=O)C2CC2)CC1";"Ki";"'='";"1.22";"nM";"8.91";"";"";"UO_0000065";"22.77";"0.47";"6.13";"11.35";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3633681";"";"0";"369.47";"0";"4.48";"4c";"CC12CC3CC(C)(C1)CC(NC(=O)NCc1cc(-c4ccco4)on1)(C3)C2";"IC50";"'='";"4.1";"nM";"8.39";"";"";"UO_0000065";"22.70";"0.42";"3.91";"10.44";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL2031929";"";"0";"369.55";"1";"5.24";"75";"O=C(CCCCCCOCc1ccccc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"66.5";"nM";"7.18";"";"";"UO_0000065";"19.42";"0.36";"1.94";"18.72";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1610486";"";"0";"286.30";"0";"4.16";"87";"O=C(Nc1cccc(C(F)(F)F)c1)NC1CCCCC1";"IC50";"'='";"8.7";"nM";"8.06";"";"";"UO_0000065";"28.15";"0.55";"3.90";"19.60";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL395714";"";"0";"292.42";"0";"2.56";"112";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](O)CC1";"IC50";"'='";"12.6";"nM";"7.90";"";"";"UO_0000065";"27.01";"0.51";"5.34";"12.87";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL3114590";"";"0";"370.88";"0";"4.45";"12";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2cccc(Cl)c2)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"21.36";"0.42";"3.47";"19.05";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3103810";"";"0";"314.43";"0";"2.65";"16";"O=C(CNC1C2CC3CC(C2)CC1C3)NOCc1ccccc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3103804";"";"0";"362.86";"0";"2.83";"10";"O=C(NOCc1ccc(Cl)cc1)C(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"2300.0";"nM";"5.64";"";"";"UO_0000065";"15.54";"0.31";"2.81";"8.36";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3628409";"";"0";"510.62";"2";"6.90";"3";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)c1ccccc1";"IC50";"'='";"45.0";"nM";"7.35";"";"";"UO_0000065";"14.39";"0.28";"0.45";"9.58";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL2436567";"";"0";"497.46";"1";"5.07";"15";"O=C(Nc1cccc(OCC(F)(F)F)c1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"35.3";"nM";"7.45";"";"";"UO_0000065";"14.98";"0.29";"2.38";"12.04";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3322827";"";"0";"420.54";"0";"2.84";"BDBM50057639";"CCCCNC(=O)C(=O)NCCCCCOc1cccc2sc(NC(C)=O)nc12";"IC50";"'>'";"500.0";"nM";"";"";"326405";"UO_0000065";"";"";"";"";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL511524";"";"0";"344.32";"0";"2.21";"4";"COc1cc2c(c(O)c1OC)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"IC50";"'='";"26400.0";"nM";"4.58";"";"";"UO_0000065";"13.30";"0.25";"2.37";"4.48";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL1258670";"";"0";"343.35";"0";"3.23";"36";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"26.66";"0.52";"5.92";"14.90";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257877";"";"0";"317.43";"0";"3.33";"14";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(C)C)cc2)CC1";"IC50";"'='";"2.8";"nM";"8.55";"";"";"UO_0000065";"26.94";"0.51";"5.22";"13.92";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258669";"";"0";"377.79";"0";"3.88";"35";"CCC(=O)N1CCC(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)CC1";"IC50";"'='";"4.1";"nM";"8.39";"";"";"UO_0000065";"22.20";"0.46";"4.51";"13.65";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257757";"";"0";"303.41";"0";"2.77";"13";"CCC(=O)N1CCC(NC(=O)Nc2ccc(CC)cc2)CC1";"IC50";"'='";"8.3";"nM";"8.08";"";"";"UO_0000065";"26.63";"0.50";"5.31";"13.15";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258335";"";"0";"309.80";"0";"2.86";"25";"CCC(=O)N1CCC(NC(=O)Nc2ccc(Cl)cc2)CC1";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"25.82";"0.52";"5.14";"13.02";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257756";"";"0";"289.38";"0";"2.52";"12";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C)cc2)CC1";"IC50";"'='";"43.0";"nM";"7.37";"";"";"UO_0000065";"25.46";"0.48";"4.85";"11.99";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1271712";"";"0";"410.36";"0";"4.00";"28";"O=C(Nc1ncc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cn1)c1ccccc1";"IC50";"'='";"21.0";"nM";"7.68";"";"";"UO_0000065";"18.71";"0.35";"3.68";"8.97";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2425007";"";"0";"453.57";"0";"3.55";"8h";"Cc1ccc(NC(=O)N2CCC(c3cc(C)nn3-c3ccc(S(N)(=O)=O)cc3)CC2)cc1";"Inhibition";"'='";"105.28";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL511137";"";"0";"426.58";"0";"3.30";"8-27";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3Cc4ccccc4C3)CC2)c(C)c1";"IC50";"'='";"49.1";"nM";"7.31";"";"";"UO_0000065";"17.13";"0.33";"4.01";"10.99";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL511291";"";"0";"444.64";"0";"4.10";"8-5";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472424";"";"0";"443.59";"0";"4.26";"8-16";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3nc4ccccc4s3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL513013";"";"0";"433.38";"1";"5.09";"6-27";"Cc1cc(C)c(C(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C)c1";"Inhibition";"'='";"34.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472424";"";"0";"443.59";"0";"4.26";"8-16";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3nc4ccccc4s3)CC2)c(C)c1";"Inhibition";"'='";"-18.0";"%";"";"Outside typical range";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469988";"";"0";"469.43";"0";"4.64";"8-40";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)c(Cl)c3)CC2)c(C)c1";"Inhibition";"'='";"97.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512872";"";"0";"435.98";"0";"3.81";"8-20";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NNc3ccccc3Cl)CC2)c(C)c1";"Inhibition";"'='";"62.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL477041";"";"0";"342.44";"0";"3.79";"21";"O=C(O)CCc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"126.0";"nM";"6.90";"";"";"UO_0000065";"20.15";"0.38";"3.11";"8.80";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3233607";"";"0";"224.26";"0";"-0.35";"7";"Cn1c(N)c(N2CCCCC2)c(=O)[nH]c1=O";"IC50";"'='";"29000.0";"nM";"4.54";"";"";"UO_0000065";"20.23";"0.39";"4.89";"5.39";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL589376";"";"0";"404.30";"0";"4.62";"39";"N#Cc1ccccc1OC1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"EC50";"'='";"0.44";"nM";"9.36";"";"";"UO_0000065";"23.14";"0.47";"4.74";"14.32";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL592741";"";"0";"457.38";"0";"4.15";"43";"CS(=O)(=O)c1cccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c1";"EC50";"'='";"0.25";"nM";"9.60";"";"";"UO_0000065";"20.99";"0.45";"5.45";"12.68";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL593658";"";"0";"288.27";"0";"3.60";"2";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCCCC1";"IC50";"'='";"24.0";"nM";"7.62";"";"";"UO_0000065";"26.43";"0.52";"4.02";"18.33";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL602743";"";"0";"302.30";"0";"3.85";"6";"CC1CCN(C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"25.62";"0.50";"3.89";"18.63";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL591319";"";"0";"302.30";"0";"3.85";"7";"CC1CCCN(C(=O)Nc2ccc(OC(F)(F)F)cc2)C1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"26.20";"0.52";"4.07";"19.05";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL585806";"";"0";"262.35";"0";"2.16";"15, diastereomeric mixture";"CC(NC(=O)N1CCCC(CO)C1)c1ccccc1";"IC50";"'>'";"3000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL594132";"";"0";"442.39";"0";"3.85";"21";"O=C(NCCC1CCOCC1)C1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"'='";"150.0";"nM";"6.82";"";"";"UO_0000065";"15.43";"0.32";"2.97";"9.66";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL606035";"";"0";"365.26";"0";"3.42";"26";"O=C(NCc1ccc(Cl)cc1Cl)N1CCN(c2ccccn2)CC1";"IC50";"'='";"6.0";"nM";"8.22";"";"";"UO_0000065";"22.51";"0.47";"4.80";"16.96";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL556717";"";"0";"436.51";"0";"4.05";"(S)-24";"CS(=O)(=O)c1ccc([C@@H](CCNC(=O)c2ccc(C#N)cc2)c2ccc(F)cc2)cc1";"EC50";"'='";"0.14";"nM";"9.85";"";"";"UO_0000065";"22.57";"0.43";"5.80";"11.32";"False";"CHEMBL1058193";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL562081";"";"0";"489.59";"0";"3.58";"25";"CS(=O)(=O)c1ccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(S(C)(=O)=O)cc2)cc1";"EC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"19.20";"0.39";"5.82";"9.65";"False";"CHEMBL1058193";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL571898";"";"0";"316.40";"0";"4.03";"9";"O=C(NCCC(c1ccccc1)c1ccccc1)c1ccncc1";"IC50";"'='";"7.9";"nM";"8.10";"";"";"UO_0000065";"25.61";"0.46";"4.07";"19.30";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL555832";"";"0";"354.54";"0";"4.72";"13";"CCCCNC(=O)NCCCCC/C=C\CCCCCCC(=O)OC";"IC50";"'='";"152.0";"nM";"6.82";"";"";"UO_0000065";"19.23";"0.37";"2.10";"10.11";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL562028";"";"0";"371.50";"1";"5.16";"24";"CCCCCc1cn(CCCC/C=C\CCCCCCC(=O)[O-])nn1.[Na+]";"IC50";"'='";"17755.0";"nM";"4.75";"";"";"UO_0000065";"13.59";"0.26";"-0.41";"6.99";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL559451";"";"0";"365.56";"1";"5.99";"26";"CCCCCC1CN=C(CCCC/C=C\CCCCCCC(=O)OC)O1";"IC50";"'='";"688.0";"nM";"6.16";"";"";"UO_0000065";"16.86";"0.32";"0.17";"12.87";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL551900";"";"0";"282.38";"0";"2.51";"28";"CCCCCNC(=O)NCCCCC#CCCC(=O)O";"IC50";"'='";"8110.0";"nM";"5.09";"";"";"UO_0000065";"18.03";"0.35";"2.58";"6.49";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL3633676";"";"0";"371.52";"0";"4.86";"3k";"CC(C)c1cc(C2CCCN2C(=O)NCC23CC4CC(CC(C4)C2)C3)no1";"IC50";"'='";"247.2";"nM";"6.61";"";"";"UO_0000065";"17.78";"0.33";"1.75";"11.32";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3633677";"";"0";"345.49";"0";"4.16";"3l";"CC(C)c1cc(CN(C)C(=O)NCC23CC4CC(CC(C4)C2)C3)on1";"IC50";"'='";"190.6";"nM";"6.72";"";"";"UO_0000065";"19.45";"0.37";"2.56";"11.51";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3617999";"";"0";"686.62";"3";"-0.01";"8";"O=C1c2cc(CO)cc(O)c2C(=O)c2c1ccc([C@]1([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3cccc(O)c3C(=O)c3c(O)cc(CO)cc31)c2O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3620672";"Non-competitive inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL576719";"";"0";"278.23";"0";"4.59";"7a";"FC(F)(F)c1ccc(Nc2noc3ccccc23)cc1";"IC50";"'='";"25.0";"nM";"7.60";"";"";"UO_0000065";"27.32";"0.52";"3.01";"19.97";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL577043";"";"0";"265.32";"0";"3.27";"6h";"c1ccc(CNc2nnc(Cc3ccccc3)o2)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL577044";"";"0";"422.33";"1";"7.28";"7hh";"FC(F)(F)c1ccc(Nc2noc3c(-c4cccc(C(F)(F)F)c4)cccc23)cc1";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"18.94";"0.36";"0.72";"21.02";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL576212";"";"0";"393.37";"1";"6.74";"7ii";"FC(F)(F)c1ccc(Nc2noc3c(-c4ccc5[nH]ccc5c4)cccc23)cc1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"20.58";"0.38";"1.36";"15.04";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL572206";"";"0";"358.75";"0";"4.00";"31";"O=C(NCc1ccccc1Cl)c1ccc(OCCC(F)(F)F)nc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL1672132";"";"0";"335.45";"0";"3.51";"10";"O=C(NC1CCN(c2ccccc2)CC1)N[C@H]1C[C@@H]1c1ccccc1";"IC50";"'='";"2.291";"nM";"8.64";"";"";"UO_0000065";"25.76";"0.47";"5.13";"19.47";"False";"CHEMBL1680920";"Inhibition of human soluble epoxide hydrolase in cell free system";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL471451";"";"0";"464.63";"1";"5.04";"8-4";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)N[C@H](C)c3cccc4ccccc34)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL67041";"";"0";"506.73";"2";"6.04";"36";"CCOC(=O)CCCCCCCCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC90";"'='";"1800.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677486";"Tested for 90 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL458165";"";"0";"413.56";"0";"3.88";"5a";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"22.00";"0.41";"5.22";"14.48";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470388";"";"0";"433.59";"0";"4.89";"19c";"O=C(NCCc1ccc(OCc2ccccc2)cc1)C(O)CC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"185.0";"nM";"6.73";"";"";"UO_0000065";"15.53";"0.29";"1.84";"11.50";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL4062676";"";"0";"269.30";"0";"2.62";"6";"Cc1ccccc1C(=O)NCc1ccc(C(=O)O)cc1";"Inhibition";"'='";"14.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4095259";"";"0";"269.30";"0";"2.62";"7";"Cc1cccc(C(=O)NCc2ccc(C(=O)O)cc2)c1";"Inhibition";"'='";"37.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL2348404";"";"0";"398.42";"0";"3.16";"3d";"CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)Oc1cccc2oc(=O)[nH]c12";"Inhibition";"'='";"90.82";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL567491";"";"0";"404.51";"0";"3.84";"13";"CCOCCn1cc(C(=O)NCCC(c2ccccc2)c2ccccc2)ccc1=O";"IC50";"'='";"2.6";"nM";"8.59";"";"";"UO_0000065";"21.22";"0.39";"4.75";"14.23";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL567283";"";"0";"369.25";"0";"3.12";"12";"CCOCCn1cc(C(=O)NCc2ccc(Cl)cc2Cl)ccc1=O";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"21.11";"0.44";"4.68";"12.92";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1087346";"";"0";"454.42";"0";"3.55";"6e, meta isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(F)c(C(=O)NCCN2CCOCC2)c1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"17.04";"0.33";"4.19";"9.36";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087450";"";"0";"400.36";"0";"5.00";"5t,para isomer";"O=C(Nc1ccc(C(=O)Nc2cccnc2)cc1)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"20.22";"0.38";"3.10";"9.74";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL215146";"";"0";"381.56";"0";"4.17";"4d";"O=C(NCC1CCN(Cc2ccccc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"18.24";"0.34";"2.79";"15.68";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL216287";"";"0";"291.44";"0";"2.25";"II";"O=C(NCC1CCNCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"4200.0";"nM";"5.38";"";"";"UO_0000065";"18.45";"0.35";"3.13";"10.11";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL386820";"";"0";"333.52";"0";"3.52";"3c";"CCCCN1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"17.75";"0.34";"2.40";"13.34";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1081703";"";"0";"385.51";"1";"5.01";"1h";"CC1(c2ccccc2)CCCN(C(=O)NCc2ccc(-c3ccccn3)cc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1078265";"";"0";"356.90";"0";"4.65";"1j";"CC1(c2ccccc2)CCCN(C(=O)NCCc2ccc(Cl)cc2)C1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"25.22";"0.49";"4.35";"27.83";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2313160";"";"0";"480.59";"0";"4.28";"7-22";"COC(=O)c1ccc2cc(NC(=O)C3CCN(S(=O)(=O)c4ccc(C)cc4C)CC3)ccc2c1";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"14.48";"0.28";"2.68";"7.50";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL564145";"";"0";"412.49";"0";"3.58";"21";"CS(=O)(=O)c1ccc(C(CCNC(=O)c2cccnc2)c2ccc(F)cc2)cc1";"EC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"22.36";"0.43";"5.64";"12.11";"False";"CHEMBL1058193";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL550589";"";"0";"398.51";"0";"3.50";"12o";"CN(C)c1cccc(NC(=O)Nc2cccc(OCCCN3CCOCC3)c2)c1";"IC50";"'='";"240.0";"nM";"6.62";"";"";"UO_0000065";"16.61";"0.31";"3.12";"10.02";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL561383";"";"0";"423.44";"0";"4.45";"19i";"O=C(Nc1ccc(OCCCN2CCOCC2)cc1)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"21.48";"0.41";"4.65";"14.48";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1085745";"";"0";"365.36";"0";"3.68";"3, Table1";"O=C(NCc1ccccc1OC(F)(F)F)N1CCC(c2ccncc2)C1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"22.32";"0.43";"4.47";"14.97";"False";"CHEMBL1118603";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL565028";"";"0";"316.40";"0";"4.63";"6";"O=C(CCC(c1ccccc1)c1ccccc1)Nc1cccnc1";"IC50";"'='";"45.0";"nM";"7.35";"";"";"UO_0000065";"23.22";"0.42";"2.72";"17.50";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL2313191";"";"0";"451.39";"0";"4.11";"7-8";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3Br)CC2)c(C)c1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"20.43";"0.47";"5.11";"13.87";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313188";"";"0";"392.57";"0";"3.40";"7-5";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NCC3CCCCC3)CC2)c(C)c1";"IC50";"'='";"5.8";"nM";"8.24";"";"";"UO_0000065";"20.98";"0.42";"4.84";"12.39";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3617994";"";"0";"418.40";"1";"-0.89";"3";"O=C1c2c(O)cccc2[C@@H]([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cc(CO)cc(O)c21";"Ki";"'='";"27800.0";"nM";"4.56";"";"";"UO_0000065";"10.89";"0.21";"5.45";"2.71";"False";"CHEMBL3620671";"Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL495793";"";"0";"471.56";"0";"4.23";"rac-1d";"Cn1nccc1Nc1ccc2c(c1)C(=O)CC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL497828";"";"0";"453.48";"0";"4.11";"2b";"CS(=O)(=O)c1ccc2c(c1)CCC1(CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC1)O2";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL561522";"";"0";"438.45";"0";"3.87";"14k";"O=C(Cc1ccc(OC(F)(F)F)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"43.0";"nM";"7.37";"";"";"UO_0000065";"16.80";"0.32";"3.50";"12.27";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL245159";"";"0";"413.56";"0";"3.88";"19c";"O=C(Nc1ccc(OCCCN2CCOCC2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"21.49";"0.40";"5.01";"14.14";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL549576";"";"0";"412.57";"0";"4.33";"20c";"O=C(CC12CC3CC(CC(C3)C1)C2)Nc1ccc(OCCCN2CCOCC2)cc1";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"21.54";"0.40";"4.56";"17.49";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2336736";"";"0";"572.15";"2";"8.03";"4a";"Cc1ccc2nc(-c3ccc(OCC4CCN(C(=O)Nc5ccc(Cl)cc5)CC4)cc3)c(NC3CCCCC3)n2c1";"IC50";"'='";"106.0";"nM";"6.97";"";"";"UO_0000065";"12.19";"0.23";"-1.06";"9.84";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL1766289";"";"0";"504.66";"1";"4.71";"11a";"CS(=O)(=O)c1ccc(-n2nc(CNC(=O)NC34CC5CC(CC(C5)C3)C4)cc2-c2ccccc2)cc1";"IC50";"'='";"25.0";"nM";"7.60";"";"";"UO_0000065";"15.06";"0.29";"2.89";"8.17";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766290";"";"0";"466.61";"0";"4.46";"11b";"CS(=O)(=O)c1ccc(-n2nc(CNC(=O)NC3CCCCCC3)cc2-c2ccccc2)cc1";"IC50";"'='";"2.6";"nM";"8.59";"";"";"UO_0000065";"18.40";"0.36";"4.13";"9.22";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766283";"";"0";"475.57";"0";"3.94";"21e";"NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3ccccc3)cc2-c2ccccc2)cc1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"19.13";"0.37";"5.16";"7.64";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL2436585";"";"0";"469.50";"0";"3.98";"33";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3CCC(O)CC3)CC2)C1";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"19.00";"0.37";"4.94";"10.86";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436582";"";"0";"441.45";"0";"3.47";"30";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3CCOC3)CC2)C1";"IC50";"'='";"2.8";"nM";"8.55";"";"";"UO_0000065";"19.37";"0.38";"5.08";"12.03";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL459260";"";"0";"616.48";"3";"0.44";"12";"O=C(O[C@H]1[C@H](Oc2c(-c3ccc(O)c(O)c3)oc3cc(O)cc(O)c3c2=O)O[C@H](CO)[C@@H](O)[C@@H]1O)c1cc(O)c(O)c(O)c1";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL245067";"PHLORIZIN";"0";"436.41";"1";"-0.20";"14";"O=C(CCc1ccc(O)cc1)c1c(O)cc(O)cc1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL2436557";"";"0";"457.57";"0";"4.57";"5";"O=C(NC12CC3CC(CC(C3)C1)C2)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"175.6";"nM";"6.75";"";"";"UO_0000065";"14.76";"0.28";"2.19";"12.83";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436590";"";"0";"427.47";"0";"4.48";"38";"CC(C)(C)C(=O)N1CCC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)C2)CC1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"21.57";"0.42";"4.74";"14.90";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436584";"";"0";"453.51";"1";"5.01";"32";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3CCCCC3)CC2)C1";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"20.19";"0.39";"4.14";"14.79";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL83103";"";"0";"195.22";"0";"2.62";"f";"c1cncc(-c2nc3ccccc3[nH]2)c1";"Activity";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL3102106";"Binding affinity to soluble epoxide hydrolase (unknown origin) at 400 uM by STD-NMR assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL2436586";"";"0";"479.42";"0";"4.77";"34";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3(C(F)(F)F)CC3)CC2)C1";"IC50";"'='";"0.3";"nM";"9.52";"";"";"UO_0000065";"19.86";"0.39";"4.75";"15.39";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL41092";"CHRYSOPHANOL";"0";"254.24";"0";"2.18";"8";"Cc1cc(O)c2c(c1)C(=O)c1cccc(O)c1C2=O";"Inhibition";"'='";"38.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL191767";"";"0";"336.52";"0";"4.24";"3";"CCCCCOCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"170.0";"nM";"6.77";"";"";"UO_0000065";"20.12";"0.39";"2.53";"13.44";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL192243";"";"0";"328.79";"0";"4.37";"12";"CCCCCOC(=O)CCCOC(=O)Oc1cccc(Cl)c1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL424822";"";"0";"349.52";"0";"4.22";"14";"CCCCCOC(=O)CCCNC(=O)CC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"430.0";"nM";"6.37";"";"";"UO_0000065";"18.22";"0.35";"2.15";"11.49";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL193888";"";"0";"246.35";"0";"2.86";"a-1";"O=C(NCCc1ccccc1)NC1CCCCC1";"IC50";"'='";"160.0";"nM";"6.80";"";"";"UO_0000065";"27.59";"0.52";"3.94";"16.52";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL517625";"";"0";"446.41";"0";"-0.34";"11";"COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(C)cc2c1C(=O)c1c(O)cccc1C2=O";"Inhibition";"'='";"50.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3634698";"";"0";"434.40";"0";"0.15";"9";"COc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(O)c3c(=O)cc(C)oc3cc2c1";"Inhibition";"'='";"38.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL464229";"";"0";"492.43";"2";"-0.62";"16";"COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc2c(c1O)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"IC50";"'='";"33000.0";"nM";"4.48";"";"";"UO_0000065";"9.10";"0.17";"5.10";"2.33";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL511524";"";"0";"344.32";"0";"2.21";"4";"COc1cc2c(c(O)c1OC)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL1818404";"";"0";"294.83";"0";"4.88";"24";"Cc1ccc(NC(=O)NC2CCCCCCC2)cc1Cl";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"31.88";"0.64";"4.52";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL3633670";"";"0";"317.43";"0";"3.25";"3e";"CCc1cc(CNC(=O)NCC23CC4CC(CC(C4)C2)C3)on1";"IC50";"'='";"29.4";"nM";"7.53";"";"";"UO_0000065";"23.73";"0.45";"4.28";"11.21";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3263297";"";"0";"554.86";"2";"7.14";"3b";"CC(NC(=O)NCCCCCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"16.39";"0.31";"1.96";"11.06";"False";"CHEMBL3270579";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1933504";"";"0";"389.52";"0";"2.80";"14-14";"N#Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"2100.0";"nM";"5.68";"";"";"UO_0000065";"14.58";"0.29";"2.88";"6.29";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL289277";"EMODIN";"0";"270.24";"0";"1.89";"6";"Cc1cc(O)c2c(c1)C(=O)c1cc(O)cc(O)c1C2=O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL68344";"";"0";"214.31";"0";"1.65";"6";"COCCCNC(=O)NC1CCCCC1";"IC50";"'='";"6200.0";"nM";"5.21";"";"";"UO_0000065";"24.30";"0.47";"3.56";"10.34";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL365939";"";"0";"218.30";"0";"3.14";"Figure 2, C7";"O=C(Nc1ccccc1)NC1CCCCC1";"IC50";"'='";"760.0";"nM";"6.12";"";"";"UO_0000065";"28.03";"0.52";"2.98";"14.88";"False";"CHEMBL3812616";"Inhibition of sEH (unknown origin)";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808350";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2016";"None"
"CHEMBL2392715";"";"0";"422.45";"0";"3.03";"10b";"CCc1nc(NC)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"19.88";"0.38";"5.37";"10.11";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1818394";"";"0";"298.43";"0";"3.35";"11";"O=C(NCCc1ccccc1)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"4.5";"nM";"8.35";"";"";"UO_0000065";"27.97";"0.52";"5.00";"20.29";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL385946";"";"0";"425.53";"0";"3.26";"7i";"O=C(NC1CCN(C(=O)c2cccc(C(=O)O)c2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"18.80";"0.35";"4.74";"8.10";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL2436558";"";"0";"457.57";"0";"4.57";"6";"O=C(NC12CC3CC(CC(C3)C1)C2)N1CCC2(CC1)CCN(C(=O)c1c(F)cccc1F)C2";"IC50";"'>'";"200.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3104445";"";"0";"499.44";"0";"4.40";"8";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)CN(C(=O)c1c(F)cccc1F)CCO2";"IC50";"'='";"5.4";"nM";"8.27";"";"";"UO_0000065";"16.55";"0.32";"3.87";"11.63";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3103805";"";"0";"342.44";"0";"2.22";"11";"O=C(NOCCc1ccccc1)C(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"4400.0";"nM";"5.36";"";"";"UO_0000065";"15.64";"0.29";"3.14";"7.94";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3970459";"";"0";"458.34";"0";"3.49";"BDBM181773";"O=C(NCc1ccc(Cl)cc1Cl)N1CC2(CCN2S(=O)(=O)c2ccc(F)cc2)C1";"IC50";"'='";"284.0";"nM";"6.55";"";"328780";"UO_0000065";"14.28";"0.31";"3.06";"9.39";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4113345";"";"0";"488.82";"0";"4.30";"BDBM181784";"O=C(NCc1ccc(Cl)cc1Cl)N[C@@H]1CCC12CN(S(=O)(=O)c1ccc(Cl)cc1)C2";"IC50";"'='";"2689.0";"nM";"5.57";"";"328791";"UO_0000065";"11.40";"0.25";"1.27";"7.10";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3936583";"";"0";"378.26";"0";"2.81";"BDBM181788";"O=C(NCc1ccc(Cl)cc1Cl)N1CC2CN(c3ncccn3)C2C1";"IC50";"'='";"361.0";"nM";"6.44";"";"328795";"UO_0000065";"17.03";"0.35";"3.63";"10.50";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL1818408";"";"0";"332.34";"1";"5.08";"28";"O=C(Nc1cccc(C(F)(F)F)c1F)NC1CCCCCCC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"28.28";"0.56";"4.32";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL3764004";"";"0";"423.43";"0";"4.65";"6b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccccc2OC(F)(F)F)cc1";"IC50";"'='";"30.0";"nM";"7.52";"";"";"UO_0000065";"17.77";"0.34";"2.87";"11.64";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3808676";"";"0";"361.47";"0";"2.33";"8k(S)";"C[C@H](NC(=O)NCCCc1ccc(S(N)(=O)=O)cc1)c1ccccc1";"IC50";"'='";"22.0";"nM";"7.66";"";"";"UO_0000065";"21.18";"0.42";"5.33";"7.56";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3808557";"";"0";"308.43";"0";"4.00";"8h(S)";"O=C(NCCCc1ccccc1)N[C@H]1CCCc2ccccc21";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"25.57";"0.47";"3.89";"19.17";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3808731";"";"0";"294.40";"0";"3.61";"8g(R)";"O=C(NCCCc1ccccc1)N[C@@H]1CCc2ccccc21";"IC50";"'='";"22.0";"nM";"7.66";"";"";"UO_0000065";"26.01";"0.48";"4.05";"18.62";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL1257405";"";"0";"371.36";"0";"3.11";"20, TPCU";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C2CC2)CC1";"Ki";"'='";"0.55";"nM";"9.26";"";"";"UO_0000065";"24.93";"0.49";"6.15";"13.10";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3236513";"";"0";"306.23";"0";"0.75";"23";"COC(=O)[C@H]1CC(=O)c2oc(=O)c3cc(O)c(O)c(O)c3c21";"IC50";"'>'";"50000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3617996";"";"0";"564.54";"3";"-2.04";"5";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@H]([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3620673";"Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL2392696";"";"0";"436.48";"0";"3.55";"10f";"Cc1nc(NC(C)C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"18.33";"0.35";"4.45";"9.63";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392694";"";"0";"470.50";"0";"4.13";"10d";"CNc1nc(-c2ccccc2)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"63.0";"nM";"7.20";"";"";"UO_0000065";"15.30";"0.29";"3.07";"8.67";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392693";"";"0";"476.55";"0";"4.51";"10c";"CNc1nc(C2CCCCC2)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL66380";"";"0";"200.24";"0";"0.70";"1";"O=C(O)CNC(=O)NC1CCCCC1";"IC50";"'>'";"500000.0";"nM";"";"Outside typical range";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL419810";"";"0";"280.37";"0";"2.12";"22";"O=C(O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"37000.0";"nM";"4.43";"";"";"UO_0000065";"15.81";"0.30";"2.31";"5.65";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL2436563";"";"0";"467.44";"1";"5.14";"11";"O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"0.3";"nM";"9.52";"";"";"UO_0000065";"20.37";"0.39";"4.38";"18.09";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436580";"";"0";"451.45";"0";"4.65";"28";"Cc1occc1C(=O)N1CCC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)C2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"20.60";"0.40";"4.65";"12.40";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436587";"";"0";"447.40";"0";"4.09";"35";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3CC3(F)F)CC2)C1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"20.79";"0.41";"5.21";"15.03";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436589";"";"0";"425.45";"0";"4.23";"37";"O=C(CC1CC1)N1CCC2(CC1)CCN(C(=O)Nc1ccc(OC(F)(F)F)cc1)C2";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"21.68";"0.42";"4.99";"14.90";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL305446";"";"0";"418.62";"1";"5.35";"25";"CC(C)=CCCC(C)CCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"16.62";"0.32";"1.61";"10.32";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL302070";"";"0";"298.43";"0";"3.13";"18";"CCCCCOC(=O)CCCNC(=O)NC1CCCCC1";"IC50";"'='";"1020.0";"nM";"5.99";"";"";"UO_0000065";"20.08";"0.39";"2.86";"8.89";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL242459";"";"0";"412.53";"0";"4.34";"t-AUCB";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"Ki";"'='";"1.5";"nM";"8.82";"";"";"UO_0000065";"21.39";"0.40";"4.48";"10.07";"False";"CHEMBL2400589";"Competitive inhibition of human recombinant soluble epoxide hydrolase using [3H]-tDPPO as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2398215";"";"0";"254.46";"1";"6.06";"6";"CCCCCCCCC(=O)CCCCCCCC";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL2400592";"Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonate) as substrate preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2398219";"";"0";"274.51";"1";"5.46";"3";"CCCCCCCC[S+]([O-])CCCCCCCC";"IC50";"'='";"1350.0";"nM";"5.87";"";"";"UO_0000065";"21.38";"0.45";"0.41";"34.39";"False";"CHEMBL2400592";"Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonate) as substrate preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL302116";"";"0";"408.54";"0";"3.31";"32";"CCOC(=O)CCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"130.0";"nM";"6.89";"";"";"UO_0000065";"16.86";"0.32";"3.58";"7.35";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL2031951";"";"0";"332.49";"0";"3.77";"125";"C=CCO[C@H]1CC[C@@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"26.73";"0.51";"5.12";"17.65";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2032043";"";"0";"393.57";"0";"2.77";"139";"O=C(NCCCCCOCCN1CCOCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.3";"nM";"8.64";"";"";"UO_0000065";"21.95";"0.42";"5.87";"13.75";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1736995";"";"0";"279.38";"0";"1.50";"145";"O=C(NN1CCOCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"12828.0";"nM";"4.89";"";"";"UO_0000065";"17.51";"0.33";"3.39";"9.13";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL214568";"";"0";"333.52";"0";"3.38";"4b";"CCCN1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"2600.0";"nM";"5.58";"";"";"UO_0000065";"16.75";"0.32";"2.21";"12.59";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214534";"";"0";"305.47";"0";"2.74";"3a";"CCN1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"3800.0";"nM";"5.42";"";"";"UO_0000065";"17.74";"0.34";"2.68";"12.22";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL425436";"";"0";"396.54";"0";"3.20";"6g";"O=C(NCC1CCN(C(=O)c2cccnc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"5.4";"nM";"8.27";"";"";"UO_0000065";"20.85";"0.39";"5.07";"11.12";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL454959";"";"0";"360.50";"0";"3.70";"14b";"O=C(CC1CCCCC1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"28.0";"nM";"7.55";"";"";"UO_0000065";"20.95";"0.40";"3.85";"14.87";"True";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL551061";"";"0";"389.88";"0";"4.09";"19l";"O=C(Nc1ccc(Cl)cc1)Nc1ccc(OCCCN2CCOCC2)cc1";"IC50";"'='";"1.5";"nM";"8.82";"";"";"UO_0000065";"22.63";"0.45";"4.73";"14.04";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1257634";"";"0";"381.38";"0";"2.13";"TUPS";"CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"T1/2";"'='";"0.0965";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327074";"";"0";"387.40";"0";"3.74";"14";"CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"T1/2";"'='";"0.3583";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327066";"";"0";"371.40";"0";"3.86";"6";"CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"T1/2";"'='";"0.335";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1668939";"";"0";"393.43";"0";"3.03";"29";"CC(C)S(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"1.17";"nM";"8.93";"";"";"UO_0000065";"22.70";"0.47";"5.90";"11.38";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327081";"";"0";"497.33";"1";"5.04";"24";"O=C(Nc1ccc(C(F)(C(F)(F)F)C(F)(F)F)cc1)NC1CCN(C(=O)CC(F)(F)F)CC1";"Ki";"'<'";"0.02";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327079";"";"0";"386.41";"0";"3.28";"22";"CC[C@H](C)C(=O)N1CCC(NC(=O)Cc2ccc(OC(F)(F)F)cc2)CC1";"Ki";"'='";"111.0";"nM";"6.96";"";"";"UO_0000065";"18.00";"0.35";"3.67";"11.86";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327078";"";"0";"387.40";"0";"3.74";"21";"CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"Ki";"'='";"0.19";"nM";"9.72";"";"";"UO_0000065";"25.09";"0.49";"5.98";"13.76";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327075";"";"0";"309.45";"0";"2.66";"15";"CCC(C)C(=O)N1CCC(NC(=O)NC2CCCCC2)CC1";"Ki";"'='";"1.23";"nM";"8.91";"";"";"UO_0000065";"28.79";"0.55";"6.25";"14.50";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327073";"";"0";"471.42";"1";"5.13";"13";"CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)CC1";"Ki";"'='";"0.02";"nM";"10.70";"";"";"UO_0000065";"22.70";"0.46";"5.57";"17.41";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327065";"";"0";"355.36";"0";"3.23";"5";"O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)C2CC2)CC1";"Ki";"'='";"0.49";"nM";"9.31";"";"";"UO_0000065";"26.20";"0.51";"6.08";"15.15";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL2397147";"";"0";"456.85";"1";"5.57";"10";"O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"20.36";"0.41";"3.73";"10.61";"False";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL561479";"";"0";"330.43";"0";"4.42";"3";"O=C(NCCCC(c1ccccc1)c1ccccc1)c1cccnc1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"20.94";"0.38";"2.50";"16.48";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL220908";"";"0";"454.28";"0";"4.94";"1{12}";"O=C(Nc1ccc(I)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.81";"0.49";"4.06";"17.87";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3327065";"";"0";"355.36";"0";"3.23";"5";"O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)C2CC2)CC1";"T1/2";"'='";"0.2433";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL2180621";"";"0";"383.49";"0";"3.85";"5c";"CCOC(=O)c1cccn1Cc1ccc(CNC(=O)NC2CCCCC2)cc1";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"19.92";"0.37";"3.79";"10.56";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL21241";"GW7647";"0";"502.77";"2";"7.28";"GW7647";"CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(=O)O";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL470833";"";"0";"366.53";"0";"2.93";"8-7";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC(C)(C)C)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472426";"";"0";"436.58";"0";"4.80";"8-10";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3cccc4ccccc34)CC2)c(C)c1";"IC50";"'='";"200.0";"nM";"6.70";"";"";"UO_0000065";"15.34";"0.30";"1.90";"10.08";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469988";"";"0";"469.43";"0";"4.64";"8-40";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)c(Cl)c3)CC2)c(C)c1";"IC50";"'='";"32.0";"nM";"7.50";"";"";"UO_0000065";"15.97";"0.34";"2.85";"11.27";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469793";"";"0";"401.53";"0";"2.72";"8-19";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccncc3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469581";"";"0";"406.59";"0";"3.71";"8-47";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCC3CCCCC3)CC2)c(C)c1";"IC50";"'='";"12.6";"nM";"7.90";"";"";"UO_0000065";"19.43";"0.39";"4.19";"11.88";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469547";"";"0";"441.38";"0";"4.02";"6-1";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"Inhibition";"'='";"15.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469764";"";"0";"478.40";"0";"4.26";"6-5";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2cccc3ncccc23)CC1";"Inhibition";"'='";"34.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471860";"";"0";"490.34";"0";"3.76";"6-9";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccc(F)cc2[N+](=O)[O-])CC1";"Inhibition";"'='";"63.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL513769";"";"0";"445.34";"0";"3.85";"6-11";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccccc2F)CC1";"Inhibition";"'='";"66.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL480496";"";"0";"595.68";"2";"7.60";"6-26";"CC(C)(C)c1cc(C(C)(C)C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C(C)(C)C)c1";"Inhibition";"'='";"88.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472284";"";"0";"452.29";"0";"4.43";"6-33";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(C(=O)Oc2ccc([N+](=O)[O-])cc2)CC1";"Inhibition";"'='";"41.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469359";"";"0";"436.52";"0";"3.61";"8-31";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(F)cc3F)CC2)c(C)c1";"Inhibition";"'='";"97.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469764";"";"0";"478.40";"0";"4.26";"6-5";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2cccc3ncccc23)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL439577";"";"0";"362.56";"0";"4.77";"24";"CCCCCOC1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"24.61";"0.47";"4.15";"17.71";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL495995";"";"0";"362.47";"0";"4.11";"rac-1f";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CCc3ccccc3O2)CC1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"23.17";"0.42";"4.29";"20.20";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL495586";"";"0";"482.60";"0";"3.94";"rac-1,3-trans-2h";"CS(=O)(=O)c1ccc2c(c1)C(=O)CC1(CCN(C(=O)N[C@@H]3CC[C@@H](c4ccccc4)C3)CC1)O2";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"16.90";"0.33";"4.21";"8.79";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1087468";"";"0";"411.36";"0";"3.96";"6g, meta isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(F)c(C(=O)N2CCOCC2)c1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"19.68";"0.38";"4.14";"11.46";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL436774";"AR9281";"2";"319.45";"0";"2.27";"14a, AR9281";"CC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"25.35";"0.48";"5.83";"13.18";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668933";"";"0";"329.32";"0";"2.84";"14l";"CC(=O)N1CCC(NC(=O)Nc2cccc(C(F)(F)F)c2)CC1";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"24.29";"0.48";"5.16";"13.02";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668934";"";"0";"345.32";"0";"2.72";"14m";"CC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"22.94";"0.45";"5.20";"11.21";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668928";"";"0";"281.40";"0";"2.02";"14g";"CC(=O)N1CCC(NC(=O)NC2CCCCCC2)CC1";"IC50";"'='";"27.0";"nM";"7.57";"";"";"UO_0000065";"26.90";"0.52";"5.55";"12.32";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL1668932";"";"0";"329.32";"0";"2.84";"14k";"CC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"IC50";"'='";"98.0";"nM";"7.01";"";"";"UO_0000065";"21.28";"0.42";"4.17";"11.41";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL516415";"";"0";"270.38";"0";"3.78";"1";"O=C(Nc1ccccc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"17.0";"nM";"7.77";"";"";"UO_0000065";"28.74";"0.53";"3.99";"18.89";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL477238";"";"0";"342.44";"0";"3.49";"20";"COC(=O)Cc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"24.52";"0.46";"4.91";"12.45";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL515028";"";"0";"383.49";"0";"3.25";"16";"O=C(Nc1cccc(C(=O)N2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"25.0";"nM";"7.60";"";"";"UO_0000065";"19.82";"0.37";"4.35";"10.76";"True";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL460836";"";"0";"449.62";"0";"3.00";"9";"O=S(=O)(Nc1cccc(OCCCN2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3600.0";"nM";"5.44";"";"";"UO_0000065";"12.11";"0.24";"2.44";"6.81";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL482845";"";"0";"376.46";"0";"3.88";"rac-2f";"O=C1CC2(CCN(C(=O)NC3CCc4ccccc43)CC2)Oc2ccccc21";"IC50";"'='";"30.0";"nM";"7.52";"";"";"UO_0000065";"19.98";"0.37";"3.64";"12.83";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL495794";"";"0";"454.55";"0";"3.16";"rac-1e";"CS(=O)(=O)c1ccc2c(c1)C(=O)CC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"18.48";"0.36";"5.24";"9.05";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1079292";"";"0";"385.90";"0";"4.17";"2i";"NC(=O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1257758";"";"0";"443.45";"0";"3.56";"57";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(S(=O)(=O)c2ccccc2)CC1";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"19.72";"0.40";"5.18";"9.97";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258336";"";"0";"354.25";"0";"2.97";"26";"CCC(=O)N1CCC(NC(=O)Nc2ccc(Br)cc2)CC1";"IC50";"'='";"3.6";"nM";"8.44";"";"";"UO_0000065";"23.84";"0.55";"5.47";"13.74";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257755";"";"0";"289.38";"0";"2.52";"11";"CCC(=O)N1CCC(NC(=O)Nc2cccc(C)c2)CC1";"IC50";"'='";"40.0";"nM";"7.40";"";"";"UO_0000065";"25.56";"0.48";"4.88";"12.04";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL470822";"";"0";"483.46";"1";"5.01";"6-22";"CC(C)(C)c1ccc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"IC50";"'='";"164.0";"nM";"6.79";"";"";"UO_0000065";"14.03";"0.30";"1.78";"10.21";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472076";"";"0";"512.85";"1";"4.91";"6-17";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2cccc3c(Cl)nccc23)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512722";"";"0";"484.41";"0";"3.67";"6-18";"CC(=O)Nc1ccc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472628";"";"0";"471.02";"1";"5.46";"8-11";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3ccc(Cl)c4ccccc34)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470834";"";"0";"386.52";"0";"3.65";"8-8";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c(C)c1";"Inhibition";"'='";"48.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469581";"";"0";"406.59";"0";"3.71";"8-47";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCC3CCCCC3)CC2)c(C)c1";"Inhibition";"'='";"92.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469553";"";"0";"467.83";"0";"4.43";"6-13";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccc(Cl)s2)CC1";"IC50";"'='";"200.0";"nM";"6.70";"";"";"UO_0000065";"14.32";"0.34";"2.27";"10.08";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512310";"";"0";"393.55";"0";"2.53";"8-43";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NN3CCCCC3)CC2)c(C)c1";"IC50";"'='";"200.0";"nM";"6.70";"";"";"UO_0000065";"17.02";"0.34";"4.17";"9.61";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL513416";"";"0";"512.35";"1";"4.45";"6-32";"COc1cc(OC(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c([N+](=O)[O-])cc1OC";"Inhibition";"'='";"71.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470833";"";"0";"366.53";"0";"2.93";"8-7";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC(C)(C)C)CC2)c(C)c1";"Inhibition";"'='";"3.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL560029";"";"0";"340.51";"0";"4.63";"12";"CCCCCCNC(=O)NCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"22.89";"0.44";"3.17";"9.94";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL445531";"";"0";"300.40";"0";"3.79";"5";"COc1ccccc1NC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"8544.0";"nM";"5.07";"";"";"UO_0000065";"16.87";"0.31";"1.28";"10.06";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL476843";"";"0";"356.47";"0";"4.18";"23";"O=C(O)CCCc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"19.9";"nM";"7.70";"";"";"UO_0000065";"21.60";"0.40";"3.52";"9.82";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL477247";"";"0";"344.41";"0";"3.27";"26";"COC(=O)c1cc(NC(=O)NC23CC4CC(CC(C4)C2)C3)ccc1O";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"23.00";"0.43";"4.65";"9.04";"True";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL222160";"";"0";"372.40";"0";"4.04";"8";"O=C(Nc1ccc(C(=O)O)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"220.0";"nM";"6.66";"";"";"UO_0000065";"17.88";"0.34";"2.62";"7.59";"True";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL2424994";"";"0";"424.53";"0";"2.85";"7a";"Cc1cc(C2CCN(C(=O)c3ccccc3)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"Inhibition";"'='";"57.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2397145";"";"0";"469.89";"1";"5.23";"8";"CNC(=O)c1cccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)c1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.15";"0.38";"3.77";"11.33";"False";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1079292";"";"0";"385.90";"0";"4.17";"2i";"NC(=O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"21.51";"0.42";"4.13";"11.00";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1079257";"";"0";"454.88";"1";"5.79";"3a";"O=C(O)CCC1(c2ccccc2C(F)(F)F)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"17.14";"0.34";"2.01";"11.19";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL556716";"";"0";"436.51";"0";"4.05";"24";"CS(=O)(=O)c1ccc(C(CCNC(=O)c2ccc(C#N)cc2)c2ccc(F)cc2)cc1";"IC50";"'='";"6.0";"nM";"8.22";"";"";"UO_0000065";"18.84";"0.36";"4.17";"9.45";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL556507";"";"0";"428.49";"0";"3.28";"22";"CS(=O)(=O)c1ccc(C(CCNC(=O)c2ccc(O)nc2)c2ccc(F)cc2)cc1";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"18.19";"0.35";"4.52";"8.09";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL561466";"";"0";"391.42";"0";"3.71";"12f";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)Nc1ccc(F)c(F)c1";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"20.33";"0.39";"4.25";"12.67";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL556303";"";"0";"315.42";"0";"4.64";"10";"O=C(NCCC(c1ccccc1)c1ccccc1)c1ccccc1";"IC50";"'='";"5.1";"nM";"8.29";"";"";"UO_0000065";"26.29";"0.47";"3.65";"28.50";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL1668939";"";"0";"393.43";"0";"3.03";"14r";"CC(C)S(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"IC50";"'='";"2.9";"nM";"8.54";"";"";"UO_0000065";"21.70";"0.45";"5.51";"10.87";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL459778";"";"0";"422.45";"0";"3.99";"14i";"O=C(Cc1ccc(C(F)(F)F)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"55.0";"nM";"7.26";"";"";"UO_0000065";"17.18";"0.33";"3.27";"14.29";"True";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469546";"";"0";"469.43";"0";"4.64";"1";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C)c1";"IC50";"'='";"20.0";"nM";"7.70";"";"";"UO_0000065";"16.40";"0.35";"3.06";"11.58";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1271658";"";"0";"409.37";"0";"4.60";"18";"O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)nc1)c1ccccc1";"IC50";"'='";"397.0";"nM";"6.40";"";"";"UO_0000065";"15.64";"0.29";"1.80";"8.80";"False";"CHEMBL1273200";"Displacement of [3H]-cDPPO from human Ephx2 by cell-based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2021563";"";"0";"427.50";"0";"3.89";"(R)-22";"CS(=O)(=O)c1ccc([C@H](CCNC(=O)c2ccc(O)cc2)c2ccc(F)cc2)cc1";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"17.87";"0.35";"3.75";"9.15";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL563732";"";"0";"311.39";"0";"2.18";"1d";"O=C(NC1CC1c1ccccc1)N1CCC(n2cncn2)CC1";"IC50";"'='";"1432.0";"nM";"5.84";"";"";"UO_0000065";"18.77";"0.35";"3.66";"9.27";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL561788";"";"0";"456.47";"1";"5.20";"2a";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccccc3C(F)(F)F)no2)CC1";"IC50";"'='";"9.0";"nM";"8.05";"";"";"UO_0000065";"17.63";"0.33";"2.85";"11.29";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL551517";"";"0";"390.45";"0";"2.97";"2h";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ncccn3)no2)CC1";"IC50";"'='";"187.0";"nM";"6.73";"";"";"UO_0000065";"17.23";"0.32";"3.76";"6.93";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL551921";"";"0";"439.52";"0";"4.73";"2j";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"18.55";"0.34";"3.42";"9.69";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL552381";"";"0";"389.46";"0";"3.19";"3d";"O=C(NC1Cc2ccccc2C1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"15.20";"0.28";"2.73";"7.04";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL552382";"";"0";"389.46";"0";"3.58";"2d";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"62.0";"nM";"7.21";"";"";"UO_0000065";"18.51";"0.34";"3.63";"8.57";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL470362";"";"0";"445.60";"1";"5.49";"20d";"O=C(CCC12CC3CC(CC(C3)C1)C2)C(=O)NCCc1ccc(OCc2ccccc2)cc1";"IC50";"'='";"685.0";"nM";"6.16";"";"";"UO_0000065";"13.83";"0.26";"0.67";"11.13";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470605";"";"0";"506.25";"1";"4.47";"6-20";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1";"Inhibition";"'='";"32.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470824";"";"0";"499.46";"0";"4.64";"6-24";"COc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C)c1C";"Inhibition";"'='";"98.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469573";"";"0";"511.09";"2";"5.57";"8-35";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC(c3ccccc3)c3ccc(Cl)cc3)CC2)c(C)c1";"Inhibition";"'='";"7.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL456836";"";"0";"423.44";"0";"4.45";"12i";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"21.25";"0.41";"4.55";"14.32";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL559669";"";"0";"399.45";"0";"3.16";"12n";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)Nc1ccc2c(c1)OCO2";"IC50";"'='";"33.0";"nM";"7.48";"";"";"UO_0000065";"18.73";"0.35";"4.32";"9.20";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL561665";"";"0";"418.62";"0";"3.76";"26c";"O=C(CC12CC3CC(CC(C3)C1)C2)NC1CCCC(OCCCN2CCOCC2)C1";"IC50";"'='";"5.2";"nM";"8.28";"";"";"UO_0000065";"19.79";"0.38";"4.52";"16.31";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL225271";"";"0";"517.15";"2";"7.55";"14";"O=C(NCCCCCCCCCCCC(=O)OCc1ccccc1Cl)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"16.96";"0.33";"1.22";"13.01";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL590106";"";"0";"397.28";"0";"4.89";"36";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccc(F)cc2)CC1";"EC50";"'='";"4.2";"nM";"8.38";"";"";"UO_0000065";"21.09";"0.44";"3.49";"20.15";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL3765763";"";"0";"395.38";"0";"4.17";"9c";"CCC(Cc1ccc(C(=O)NCc2ccc(OC(F)(F)F)cc2)cc1)C(=O)O";"IC50";"'='";"14000.0";"nM";"4.85";"";"";"UO_0000065";"12.28";"0.24";"0.68";"6.42";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3818149";"";"0";"460.50";"1";"5.12";"5d";"CC/C(=C\c1ccc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)cc1)C(=O)O";"IC50";"'='";"27.0";"nM";"7.57";"";"";"UO_0000065";"16.44";"0.31";"2.45";"10.87";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL3318038";"";"0";"471.03";"1";"7.13";"MD78";"CCCCCCC(Sc1nc(Cl)cc(Nc2ccc(Nc3ccccc3)cc2)n1)C(=O)O";"IC50";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL1079361";"";"0";"335.41";"0";"4.41";"1b";"CC1(c2ccccc2)CCCN(C(=O)Nc2noc3ccccc23)C1";"IC50";"'='";"59.0";"nM";"7.23";"";"";"UO_0000065";"21.55";"0.39";"2.82";"12.39";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1083622";"";"0";"452.51";"0";"4.53";"6, Table1";"O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)N1CCC(Oc2cnccn2)CC1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.89";"0.37";"4.47";"13.36";"False";"CHEMBL1118603";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL578781";"";"0";"279.22";"0";"3.99";"7k";"FC(F)(F)c1ccc(Nc2noc3cccnc23)cc1";"IC50";"'='";"1100.0";"nM";"5.96";"";"";"UO_0000065";"21.34";"0.41";"1.97";"11.70";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL567294";"";"0";"426.79";"0";"2.97";"43";"O=C(NCc1ccc(-n2cnnn2)cc1Cl)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"21.0";"nM";"7.68";"";"";"UO_0000065";"17.99";"0.36";"4.71";"8.10";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL551517";"";"0";"390.45";"0";"2.97";"2h";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ncccn3)no2)CC1";"IC50";"'='";"33.0";"nM";"7.48";"";"";"UO_0000065";"19.16";"0.35";"4.51";"7.71";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL552061";"";"0";"439.52";"0";"4.73";"2i";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3nccc4ccccc34)no2)CC1";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"18.20";"0.33";"3.27";"9.51";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL572205";"";"0";"379.17";"0";"4.26";"14";"O=C(NCc1ccc(Cl)cc1Cl)c1ccc(OCC(F)(F)F)nc1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"20.43";"0.44";"3.48";"15.12";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL566658";"";"0";"402.39";"0";"2.75";"36";"CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL477067";"";"0";"300.40";"0";"3.79";"7";"COc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"26.14";"0.49";"4.06";"15.60";"True";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL192272";"";"0";"335.49";"0";"3.83";"15";"CCCCCOC(=O)CCCNC(=O)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"9400.0";"nM";"5.03";"";"";"UO_0000065";"14.98";"0.29";"1.20";"9.07";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL565841";"";"0";"358.75";"0";"4.00";"32";"O=C(NCc1ccc(Cl)cc1)c1ccc(OCCC(F)(F)F)nc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL1087344";"";"0";"404.87";"0";"3.95";"6b, meta isomer";"O=C(Nc1ccc(Cl)cc1)Nc1ccc(F)c(C(=O)NCCN2CCCC2)c1";"IC50";"'='";"760.0";"nM";"6.12";"";"";"UO_0000065";"15.11";"0.30";"2.17";"8.33";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088547";"";"0";"450.46";"0";"4.40";"5k,para isomer";"CC(C)N1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)CC1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"18.64";"0.36";"4.00";"11.36";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088698";"";"0";"420.44";"0";"4.18";"5l,para isomer";"O=C(Nc1ccc(C(=O)NCCN2CCCC2)cc1)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"48.0";"nM";"7.32";"";"";"UO_0000065";"17.41";"0.33";"3.14";"9.96";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088699";"";"0";"450.58";"0";"4.44";"5m,para isomer";"O=C(Nc1ccc(C(=O)NCCN2CCOCC2)cc1)Nc1ccc(C2CCCCC2)cc1";"IC50";"'='";"19.0";"nM";"7.72";"";"";"UO_0000065";"17.14";"0.32";"3.28";"9.34";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088700";"";"0";"426.56";"0";"2.84";"5n,para isomer";"O=C(Nc1ccc(C(=O)NCCN2CCOCC2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"19.98";"0.38";"5.68";"10.31";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1086694";"";"0";"402.88";"0";"3.05";"5q,para isomer";"O=C(Nc1ccc(Cl)cc1)Nc1ccc(C(=O)NCCN2CCOCC2)cc1";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"19.35";"0.38";"4.75";"9.43";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087490";"";"0";"393.37";"0";"3.82";"5y,para isomer";"O=C(Nc1ccc(C(=O)N2CCOCC2)cc1)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"21.10";"0.40";"4.48";"11.75";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088565";"";"0";"382.51";"0";"2.82";"5f, para isomer";"O=C(Nc1ccc(C(=O)N2CCNCC2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"20.71";"0.39";"5.10";"10.78";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1257285";"";"0";"422.41";"0";"3.34";"49";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)Cc2ccccn2)CC1";"IC50";"'='";"3.1";"nM";"8.51";"";"";"UO_0000065";"20.14";"0.39";"5.17";"10.18";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1615212";"";"0";"262.31";"0";"2.84";"1";"N#Cc1ccc(C(=O)N[C@H]2C[C@@H]2c2ccccc2)cc1";"IC50";"'='";"565.0";"nM";"6.25";"";"";"UO_0000065";"23.82";"0.43";"3.41";"11.81";"False";"CHEMBL1680920";"Inhibition of human soluble epoxide hydrolase in cell free system";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL245158";"";"0";"419.61";"0";"3.30";"26";"O=C(NC1CCC(OCCCN2CCOCC2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"20.84";"0.40";"5.44";"13.92";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245151";"";"0";"407.60";"0";"3.16";"19";"O=C(NCCCCCOCCCN1CCOCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"9.0";"nM";"8.05";"";"";"UO_0000065";"19.74";"0.38";"4.89";"12.81";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245146";"";"0";"380.57";"0";"4.26";"13";"CCCOCCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.5";"nM";"8.60";"";"";"UO_0000065";"22.60";"0.44";"4.34";"14.44";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL1632491";"";"0";"526.72";"2";"5.49";"21c";"CC(C)(C)OC(=O)N1CCN(CCCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1";"IC50";"'='";"20.1";"nM";"7.70";"";"";"UO_0000065";"14.61";"0.28";"2.21";"9.26";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL470361";"";"0";"403.52";"1";"5.38";"20b";"O=C(CC12CC3CC(CC(C3)C1)C2)C(=O)Nc1ccc(OCc2ccccc2)cc1";"IC50";"'='";"1110.0";"nM";"5.96";"";"";"UO_0000065";"14.76";"0.27";"0.57";"10.75";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL459778";"";"0";"422.45";"0";"3.99";"6f";"O=C(Cc1ccc(C(F)(F)F)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"55.0";"nM";"7.26";"";"";"UO_0000065";"17.18";"0.33";"3.27";"14.29";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1632488";"";"0";"512.70";"2";"5.10";"20a";"CC(C)(C)OC(=O)N1CCN(CCCOc2ccccc2NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"39.4";"nM";"7.41";"";"";"UO_0000065";"14.44";"0.27";"2.30";"8.91";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL513535";"";"0";"502.99";"2";"5.00";"8-32";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)c(C(F)(F)F)c3)CC2)c(C)c1";"IC50";"'='";"173.0";"nM";"6.76";"";"";"UO_0000065";"13.44";"0.28";"1.76";"10.17";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL513874";"";"0";"368.50";"0";"1.78";"8-25";"COCCNC(=O)C1CCN(S(=O)(=O)c2c(C)cc(C)cc2C)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469372";"";"0";"393.55";"0";"1.88";"8-50";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCNCC3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469553";"";"0";"467.83";"0";"4.43";"6-13";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccc(Cl)s2)CC1";"Inhibition";"'='";"52.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472426";"";"0";"436.58";"0";"4.80";"8-10";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3cccc4ccccc34)CC2)c(C)c1";"Inhibition";"'='";"50.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2397137";"";"0";"470.88";"0";"4.63";"17";"CNC(=O)c1cc(O[C@H]2CC[C@@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"19.75";"0.40";"4.67";"10.07";"False";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2397143";"";"0";"452.43";"0";"3.85";"6";"CNC(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"20.56";"0.40";"5.45";"9.16";"True";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2397142";"";"0";"484.91";"0";"4.97";"5";"CN(C)C(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"19.18";"0.38";"4.33";"11.13";"False";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL244067";"";"0";"395.58";"0";"3.95";"23";"CCOCCOCCOCCCCCNC(=O)CC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"20.22";"0.39";"4.05";"14.09";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL242255";"";"0";"276.42";"0";"3.59";"ACU";"O=C(NC1CCCCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"31.82";"0.60";"5.21";"21.39";"True";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL243337";"";"0";"447.42";"1";"5.41";"16a";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(Br)cc2)CC1";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"19.86";"0.43";"3.48";"17.65";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL242460";"";"0";"461.44";"1";"5.54";"9b";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2ccc(Br)cc2)CC1";"IC50";"'='";"2.1";"nM";"8.68";"";"";"UO_0000065";"18.81";"0.41";"3.14";"17.23";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL397694";"";"0";"413.52";"0";"4.55";"13c";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc([N+](=O)[O-])cc2)CC1";"IC50";"'='";"0.64";"nM";"9.19";"";"";"UO_0000065";"22.23";"0.42";"4.64";"9.83";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL1078565";"";"0";"400.91";"1";"5.16";"2c";"O=C(O)CCCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"19.76";"0.39";"2.76";"11.37";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078754";"";"0";"400.91";"0";"4.86";"2e";"COC(=O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2425005";"";"0";"439.54";"0";"3.24";"8f";"Cc1cc(C2CCN(C(=O)Nc3ccccc3)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"Inhibition";"'='";"92.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL427695";"";"0";"398.55";"0";"4.65";"13b";"COc1ccc(O[C@H]2CC[C@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1";"IC50";"'='";"0.87";"nM";"9.06";"";"";"UO_0000065";"22.73";"0.43";"4.41";"15.20";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL395989";"";"0";"396.58";"1";"5.09";"3c";"Cc1ccccc1CO[C@H]1CC[C@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"22.18";"0.41";"3.71";"17.47";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL3114608";"";"0";"404.47";"0";"2.98";"39";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccc(-c3nn[nH]n3)cc2)CC1";"IC50";"'='";"3.3";"nM";"8.48";"";"";"UO_0000065";"20.97";"0.39";"5.50";"8.83";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114592";"";"0";"350.46";"0";"4.10";"14";"Cc1ccccc1OC1CCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1";"IC50";"'='";"3.1";"nM";"8.51";"";"";"UO_0000065";"24.28";"0.45";"4.41";"20.47";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114612";"";"0";"337.42";"0";"3.19";"5";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccccn2)CC1";"IC50";"'='";"27.4";"nM";"7.56";"";"";"UO_0000065";"22.41";"0.41";"4.37";"13.89";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL219385";"";"0";"502.66";"1";"3.13";"Table 3,r17c1";"CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"13.93";"0.27";"3.87";"5.12";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3114614";"";"0";"337.42";"0";"3.19";"7";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccncc2)CC1";"IC50";"'='";"24.4";"nM";"7.61";"";"";"UO_0000065";"22.56";"0.42";"4.42";"13.98";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL373655";"";"0";"470.64";"0";"3.45";"3{1}";"CN(C)c1cccc2c(S(=O)(=O)NCCNC(=O)NC34CC5CC(CC(C5)C3)C4)cccc12";"Inhibition";"'='";"19.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3103821";"";"0";"428.53";"0";"2.44";"31";"CON(C)C(=O)C(=O)N(C)c1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"Ratio IC50";"'='";"3.0";"";"";"";"";"";"";"";"";"";"False";"CHEMBL3107380";"Ratio of IK950 IC50 to compound IC50 for recombinant human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL225271";"";"0";"517.15";"2";"7.55";"14";"O=C(NCCCCCCCCCCCC(=O)OCc1ccccc1Cl)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"290.0";"nM";"6.54";"";"";"UO_0000065";"12.64";"0.25";"-1.01";"9.70";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224449";"";"0";"482.71";"1";"6.90";"13";"O=C(NCCCCCCCCCCCC(=O)OCc1ccccc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"18.02";"0.34";"1.80";"12.90";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL2436578";"";"0";"452.43";"0";"4.04";"26";"Cc1cc(C(=O)N2CCC3(CCN(C(=O)Nc4ccc(OC(F)(F)F)cc4)C3)CC2)no1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"20.77";"0.40";"5.36";"10.69";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL215820";"";"0";"405.54";"0";"2.75";"8g";"O=C(O)CCCC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"41.0";"nM";"7.39";"";"";"UO_0000065";"18.22";"0.35";"4.64";"7.48";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL215874";"";"0";"347.50";"0";"2.90";"6b";"CCC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"8.7";"nM";"8.06";"";"";"UO_0000065";"23.20";"0.44";"5.16";"13.12";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL374322";"";"0";"386.51";"0";"4.78";"1{1}";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"86.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL2392707";"";"0";"354.46";"0";"2.06";"19";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3C)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL561707";"";"0";"354.54";"0";"4.97";"2";"CCCCCNC(=O)N(C)CCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"71.5";"nM";"7.15";"";"";"UO_0000065";"20.15";"0.39";"2.18";"10.26";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL552044";"";"0";"382.55";"0";"3.86";"17";"CCCCN(C)C(=O)C(=O)N(C)CCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"17622.0";"nM";"4.75";"";"";"UO_0000065";"12.43";"0.24";"0.89";"6.10";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL559454";"";"0";"353.55";"1";"5.57";"19";"CCCCCCC(=O)N(C)CCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"11194.0";"nM";"4.95";"";"";"UO_0000065";"14.00";"0.27";"-0.62";"8.59";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL560026";"";"0";"381.60";"1";"6.35";"20";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCC(=O)O)C(C)C";"IC50";"'='";"10712.0";"nM";"4.97";"";"";"UO_0000065";"13.02";"0.25";"-1.38";"8.63";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL564272";"";"0";"372.44";"0";"3.11";"14e";"O=C(Cc1ccc(F)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"550.0";"nM";"6.26";"";"";"UO_0000065";"16.81";"0.32";"3.15";"12.32";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL560982";"";"0";"457.42";"0";"4.47";"13k";"O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccc(F)c(OCCCN2CCOCC2)c1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"19.89";"0.39";"4.63";"12.62";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL564986";"";"0";"440.44";"0";"4.13";"15i";"O=C(Cc1ccc(C(F)(F)F)cc1)Nc1ccc(F)c(OCCCN2CCOCC2)c1";"IC50";"'='";"156.0";"nM";"6.81";"";"";"UO_0000065";"15.45";"0.30";"2.68";"13.40";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL224395";"";"0";"433.68";"1";"5.68";"17";"CC(C)NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"16.14";"0.31";"1.32";"9.97";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL223956";"";"0";"430.63";"1";"5.33";"6";"C#CCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"16.26";"0.31";"1.67";"10.38";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL438838";"";"0";"531.76";"2";"5.66";"19";"O=C(CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1ccccc1";"IC50";"'='";"1.9";"nM";"8.72";"";"";"UO_0000065";"16.40";"0.32";"3.06";"8.36";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224395";"";"0";"433.68";"1";"5.68";"17";"CC(C)NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.9";"nM";"8.54";"";"";"UO_0000065";"19.69";"0.38";"2.86";"12.16";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL390796";"";"0";"526.81";"2";"7.67";"12";"O=C(NCCCCCCCCCCCC(=O)OC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.5";"nM";"8.82";"";"";"UO_0000065";"16.75";"0.32";"1.15";"13.09";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL1087983";"";"0";"371.44";"0";"2.59";"5a, meta isomer";"O=C(O)CNC(=O)c1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"800.0";"nM";"6.10";"";"";"UO_0000065";"16.41";"0.31";"3.51";"5.67";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL560538";"";"0";"240.31";"0";"2.44";"4";"O=C(NCCCc1ccccc1)c1cccnc1";"IC50";"'='";"700.0";"nM";"6.16";"";"";"UO_0000065";"25.61";"0.47";"3.71";"14.66";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL195748";"";"0";"327.81";"0";"4.40";"9";"CCCCCOC(=O)CCCOC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"25200.0";"nM";"4.60";"";"";"UO_0000065";"14.03";"0.29";"0.20";"7.12";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL497829";"";"0";"468.40";"0";"4.33";"2c";"CS(=O)(=O)c1ccc2c(c1)CCC1(CCN(C(=O)Cc3ccc(Cl)cc3Cl)CC1)O2";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL226335";"RUTIN";"2";"610.52";"3";"-1.69";"18";"C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O";"IC50";"'='";"24300.0";"nM";"4.61";"";"";"UO_0000065";"7.56";"0.15";"6.30";"1.71";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1221722";"";"0";"480.38";"2";"-0.83";"19";"O=c1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12";"IC50";"'='";"17230.0";"nM";"4.76";"";"";"UO_0000065";"9.92";"0.19";"5.59";"2.06";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL550046";"";"0";"398.46";"0";"2.70";"14q";"O=C(Cc1ccc2c(c1)OCO2)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"365.0";"nM";"6.44";"";"";"UO_0000065";"16.16";"0.30";"3.74";"9.29";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1082684";"";"0";"396.37";"0";"3.13";"4, Table1";"O=C(NCc1ccccc1OC(F)(F)F)N1CCC(Oc2ncccn2)CC1";"IC50";"'='";"40.0";"nM";"7.40";"";"";"UO_0000065";"18.66";"0.36";"4.27";"9.66";"False";"CHEMBL1118602";"Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL3233604";"";"0";"210.30";"0";"2.66";"2";"O=C(CC1CCCC1)Nc1nccs1";"IC50";"'='";"15000.0";"nM";"4.82";"";"";"UO_0000065";"22.94";"0.47";"2.16";"11.49";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL192273";"";"0";"333.56";"1";"5.99";"16";"CCCCCCCCCCCC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"5000.0";"nM";"5.30";"";"";"UO_0000065";"15.89";"0.30";"-0.69";"18.22";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL1097522";"";"0";"434.46";"0";"4.52";"5j, meta isomer";"CC(C)N1CCN(C(=O)c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)CC1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"18.01";"0.34";"3.30";"12.10";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1258903";"";"0";"457.39";"0";"4.81";"39";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2C)CC1";"IC50";"'='";"17.0";"nM";"7.77";"";"";"UO_0000065";"16.99";"0.34";"2.96";"12.65";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257633";"";"0";"289.38";"0";"2.52";"10";"CCC(=O)N1CCC(NC(=O)Nc2ccccc2C)CC1";"IC50";"'='";"1700.0";"nM";"5.77";"";"";"UO_0000065";"19.94";"0.38";"3.25";"9.39";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258105";"";"0";"360.46";"0";"2.05";"19";"CCC(=O)N1CCC(NC(=O)Nc2ccc(N3CCOCC3)cc2)CC1";"IC50";"'='";"2000.0";"nM";"5.70";"";"";"UO_0000065";"15.81";"0.30";"3.65";"7.71";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1668940";"";"0";"409.43";"0";"2.91";"14s";"CC(C)S(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"21.48";"0.44";"5.89";"10.02";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668935";"";"0";"355.50";"0";"1.68";"14n";"CS(=O)(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"1.9";"nM";"8.72";"";"";"UO_0000065";"24.53";"0.50";"7.04";"11.11";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668935";"";"0";"355.50";"0";"1.68";"14n";"CS(=O)(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"3.9";"nM";"8.41";"";"";"UO_0000065";"23.65";"0.48";"6.73";"10.71";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL1668937";"";"0";"408.38";"0";"3.41";"14p";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2cccnc2)CC1";"IC50";"'='";"6.7";"nM";"8.17";"";"";"UO_0000065";"20.02";"0.38";"4.76";"9.78";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL1668926";"";"0";"279.38";"0";"1.49";"14e";"CC(=O)N1CCC(NC(=O)NC2C3CCC2CC3)CC1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"28.11";"0.54";"6.36";"12.78";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668923";"";"0";"355.43";"0";"2.45";"14b";"CC(=O)N1CCC(NC(=O)NC23CC4CC(F)(CC(F)(C4)C2)C3)CC1";"IC50";"'='";"58.0";"nM";"7.24";"";"";"UO_0000065";"20.36";"0.40";"4.79";"11.78";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL219747";"";"0";"412.54";"1";"1.01";"Table 1, r17c1";"N=C(N)NCCC[C@H](NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL264591";"";"0";"375.47";"0";"2.21";"Table 1, r13c1";"O=C(CCCNC(=O)NC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)O";"IC50";"'='";"21000.0";"nM";"4.68";"";"";"UO_0000065";"12.46";"0.24";"2.47";"4.35";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL562869";"";"0";"325.42";"0";"2.26";"1b";"Cn1cc(C2CCN(C(=O)NC3CC3c3ccccc3)CC2)nn1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"21.27";"0.39";"4.66";"10.98";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL1257170";"";"0";"442.83";"0";"4.06";"48";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2ccc(Cl)nc2)CC1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"20.82";"0.42";"5.16";"11.04";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL550242";"";"0";"403.49";"0";"3.58";"3c";"O=C(NC1CCc2ccccc2C1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"49.0";"nM";"7.31";"";"";"UO_0000065";"18.12";"0.33";"3.73";"8.69";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL1257516";"";"0";"325.41";"0";"3.36";"8";"CCC(=O)N1CCC(NC(=O)Nc2ccc3ccccc3c2)CC1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"26.19";"0.48";"5.16";"13.87";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257632";"";"0";"295.43";"0";"2.41";"3";"CCC(=O)N1CCC(NC(=O)NC2CCCCCC2)CC1";"IC50";"'='";"3.9";"nM";"8.41";"";"";"UO_0000065";"28.46";"0.55";"6.00";"13.69";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257989";"";"0";"319.36";"0";"1.94";"17";"CCC(=O)N1CCC(NC(=O)Nc2ccc3c(c2)OCO3)CC1";"IC50";"'='";"61.0";"nM";"7.21";"";"";"UO_0000065";"22.59";"0.43";"5.27";"9.03";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257517";"";"0";"399.29";"0";"3.26";"53";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C(F)(F)F)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"23.54";"0.48";"6.14";"13.30";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL552382";"";"0";"389.46";"0";"3.58";"2d";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"34.0";"nM";"7.47";"";"";"UO_0000065";"19.18";"0.35";"3.89";"8.88";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL564757";"";"0";"389.46";"0";"3.58";"2e";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3cccnc3)no2)CC1";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"20.25";"0.37";"4.31";"9.37";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL376597";"";"0";"561.85";"2";"7.48";"22";"CCCCCCCCC(NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'='";"210.0";"nM";"6.68";"";"";"UO_0000065";"11.89";"0.23";"-0.80";"6.21";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL375113";"";"0";"610.79";"2";"1.19";"21";"O=C(CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)NCC(=O)N[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O";"IC50";"'='";"220.0";"nM";"6.66";"";"";"UO_0000065";"10.90";"0.21";"5.47";"3.51";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224580";"";"0";"419.65";"1";"5.29";"16";"CCNC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"16.68";"0.32";"1.71";"9.97";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224266";"";"0";"708.98";"2";"3.92";"20";"CCCCCCCC(NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O";"IC50";"'='";"7.5";"nM";"8.12";"";"";"UO_0000065";"11.46";"0.22";"4.20";"4.29";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224579";"";"0";"532.77";"2";"8.05";"15";"O=C(NCCCCCCCCCCCC(=O)OCc1cccc2ccccc12)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.4";"nM";"8.62";"";"";"UO_0000065";"16.18";"0.30";"0.57";"12.78";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL223281";"";"0";"448.69";"1";"6.50";"8";"CCCCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"20.27";"0.39";"2.60";"13.49";"True";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL438867";"";"0";"402.54";"0";"4.21";"28";"CCOCCOCCOc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"21.72";"0.41";"4.53";"12.71";"True";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245148";"";"0";"472.67";"1";"5.10";"17";"CCc1ccc(OCCOCCOCCCCCNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"18.55";"0.35";"3.67";"12.74";"True";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245145";"";"0";"364.57";"0";"4.88";"12";"CCCC(C)COCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"21.94";"0.42";"3.12";"15.89";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL387280";"";"0";"439.56";"0";"3.51";"8j";"O=C(NCC1CCN(C(=O)c2ccc(C(=O)O)cc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"11.8";"nM";"7.93";"";"";"UO_0000065";"18.04";"0.34";"4.42";"8.03";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL221792";"";"0";"372.40";"0";"4.04";"10";"O=C(Nc1cccc(C(=O)O)c1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"590.0";"nM";"6.23";"";"";"UO_0000065";"16.73";"0.32";"2.19";"7.11";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL591788";"";"0";"329.23";"0";"3.38";"18";"O=C(N/C=C/c1ccc(Cl)cc1Cl)N1CCCC(CO)C1";"IC50";"'='";"230.0";"nM";"6.64";"";"";"UO_0000065";"20.16";"0.43";"3.26";"12.63";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL67158";"";"0";"282.47";"0";"4.76";"20";"CCCCCCCCCCNC(=O)NC1CCCCC1";"IC50";"'='";"140.0";"nM";"6.85";"";"";"UO_0000065";"24.26";"0.47";"2.09";"16.66";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL66542";"";"0";"454.57";"0";"4.22";"26";"CCOC(=O)/C=C/c1ccc(OC(=O)CCCNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"200.0";"nM";"6.70";"";"";"UO_0000065";"14.74";"0.28";"2.48";"7.15";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL1632458";"";"0";"412.58";"0";"3.45";"24c";"O=C(Nc1ccc(OCCCN2CCNCC2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"156.0";"nM";"6.81";"";"";"UO_0000065";"16.50";"0.31";"3.36";"10.37";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632455";"";"0";"454.62";"0";"3.71";"28a";"CC(=O)N1CCN(CCCOc2ccccc2NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"994.0";"nM";"6.00";"";"";"UO_0000065";"13.20";"0.25";"2.29";"8.12";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL513751";"";"0";"401.53";"0";"2.72";"8-18";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3cccnc3)CC2)c(C)c1";"Inhibition";"'='";"23.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472078";"";"0";"436.30";"0";"4.07";"6-36";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470824";"";"0";"499.46";"0";"4.64";"6-24";"COc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C)c1C";"IC50";"'='";"23.9";"nM";"7.62";"";"";"UO_0000065";"15.26";"0.33";"2.98";"10.07";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470832";"";"0";"450.60";"1";"5.11";"8-6";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3c(C)ccc4ccccc34)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1603947";"";"0";"378.54";"0";"3.23";"14-23";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"570.0";"nM";"6.24";"";"";"UO_0000065";"16.50";"0.33";"3.01";"9.39";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933513";"";"0";"436.57";"0";"2.89";"14-24";"CC(=O)COc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"1300.0";"nM";"5.89";"";"";"UO_0000065";"13.48";"0.27";"3.00";"6.34";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933647";"";"0";"416.95";"0";"3.72";"14-30";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2Cl)CC1";"IC50";"'='";"27.0";"nM";"7.57";"";"";"UO_0000065";"18.15";"0.38";"3.85";"11.38";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL566048";"";"0";"451.85";"0";"2.90";"38";"CNS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1";"IC50";"'='";"31.0";"nM";"7.51";"";"";"UO_0000065";"16.62";"0.35";"4.61";"7.71";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL1079256";"";"0";"386.88";"0";"4.77";"entA-2b";"O=C(O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"2000.0";"nM";"5.70";"";"";"UO_0000065";"14.73";"0.29";"0.93";"8.18";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1079061";"";"0";"512.53";"2";"6.68";"3g";"O=C(O)CCC1(c2ccc(-c3ccccc3)cc2)CCCN(C(=O)Nc2ccc(OC(F)(F)F)cc2)C1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"15.80";"0.30";"1.42";"10.27";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL589138";"";"0";"472.39";"0";"3.65";"46";"CNS(=O)(=O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"IC50";"'='";"5.2";"nM";"8.28";"";"";"UO_0000065";"17.54";"0.38";"4.63";"9.44";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL566048";"";"0";"451.85";"0";"2.90";"38";"CNS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"17.38";"0.37";"4.95";"8.06";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL567503";"";"0";"332.40";"0";"3.33";"7";"O=C(NCCC(c1ccccc1)c1ccccc1)c1ccc(=O)[nH]c1";"IC50";"'='";"8.1";"nM";"8.09";"";"";"UO_0000065";"24.34";"0.44";"4.76";"13.06";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL398166";"";"0";"238.33";"0";"1.25";"1";"O=C(NCCO)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"482.0";"nM";"6.32";"";"";"UO_0000065";"26.51";"0.51";"5.07";"10.29";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245152";"";"0";"445.63";"0";"2.01";"20";"CS(=O)(=O)NCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"58.0";"nM";"7.24";"";"";"UO_0000065";"16.24";"0.33";"5.23";"6.84";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245147";"";"0";"394.60";"0";"4.65";"14";"CCCOCCCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.3";"nM";"8.64";"";"";"UO_0000065";"21.89";"0.42";"3.99";"14.50";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL242592";"";"0";"252.36";"0";"1.64";"3";"O=C(NCCCO)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"746.0";"nM";"6.13";"";"";"UO_0000065";"24.28";"0.46";"4.49";"9.99";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL552061";"";"0";"439.52";"0";"4.73";"2i";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3nccc4ccccc34)no2)CC1";"IC50";"'='";"35.0";"nM";"7.46";"";"";"UO_0000065";"16.96";"0.31";"2.73";"8.86";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL243124";"";"0";"451.44";"1";"6.09";"3e";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2c(Cl)cccc2Cl)CC1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"19.43";"0.40";"2.68";"17.41";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL1766300";"";"0";"542.58";"2";"5.72";"21a";"CS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3cccc(C(F)(F)F)c3)cc2-c2ccccc2)cc1";"IC50";"'='";"3.4";"nM";"8.47";"";"";"UO_0000065";"15.61";"0.30";"2.75";"9.10";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1079290";"";"0";"358.87";"0";"4.29";"2g";"O=C(Nc1ccc(Cl)cc1)N1CCCC(CCO)(c2ccccc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1078755";"";"0";"367.88";"1";"5.21";"2f";"N#CCCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL2424993";"";"0";"389.52";"0";"3.09";"6f";"CCCC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(C)(=O)=O)cc2)CC1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL564975";"";"0";"311.39";"0";"2.18";"1a";"O=C(NC1CC1c1ccccc1)N1CCC(n2ccnn2)CC1";"IC50";"'='";"430.0";"nM";"6.37";"";"";"UO_0000065";"20.45";"0.38";"4.19";"10.10";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL555347";"";"0";"417.39";"0";"4.56";"3a";"O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"19.54";"0.37";"3.59";"9.69";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL566658";"";"0";"402.39";"0";"2.75";"36";"CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"17.29";"0.35";"4.21";"8.15";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL219042";"";"0";"474.60";"0";"2.50";"Table 3, r2c1";"C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"260.0";"nM";"6.58";"";"";"UO_0000065";"13.87";"0.26";"4.09";"4.82";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219695";"";"0";"228.29";"0";"1.48";"Table 1, r8c1";"O=C(O)CCCNC(=O)NC1CCCCC1";"IC50";"'='";"36000.0";"nM";"4.44";"";"";"UO_0000065";"19.47";"0.38";"2.96";"5.67";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL66518";"";"0";"214.26";"0";"0.79";"Table 1, r2c1";"COC(=O)CNC(=O)NC1CCCCC1";"IC50";"'='";"70000.0";"nM";"4.16";"";"";"UO_0000065";"19.39";"0.38";"3.36";"6.16";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL458166";"";"0";"361.49";"0";"3.24";"5b";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)NC1CCCCC1";"IC50";"'='";"3.9";"nM";"8.41";"";"";"UO_0000065";"23.26";"0.44";"5.17";"13.38";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2313178";"";"0";"451.39";"0";"4.11";"7-40";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(Br)cc3)CC2)c(C)c1";"IC50";"'='";"45.0";"nM";"7.35";"";"";"UO_0000065";"16.28";"0.37";"3.24";"11.05";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313164";"";"0";"378.54";"0";"3.15";"7-26";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCC3)CC2)c(C)c1";"IC50";"'='";"102.0";"nM";"6.99";"";"";"UO_0000065";"18.47";"0.37";"3.84";"10.52";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL224449";"";"0";"482.71";"1";"6.90";"13";"O=C(NCCCCCCCCCCCC(=O)OCc1ccccc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"130.0";"nM";"6.89";"";"";"UO_0000065";"14.27";"0.27";"-0.01";"10.21";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224912";"";"0";"448.69";"1";"6.50";"9";"CCC(C)OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"15.60";"0.30";"0.50";"10.38";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224357";"";"0";"406.61";"1";"5.33";"2";"COC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"17.22";"0.33";"1.67";"10.38";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL375113";"";"0";"610.79";"2";"1.19";"21";"O=C(CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)NCC(=O)N[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O";"IC50";"'='";"7.6";"nM";"8.12";"";"";"UO_0000065";"13.29";"0.26";"6.93";"4.28";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL1097524";"";"0";"450.58";"0";"4.44";"5m, meta isomer";"O=C(Nc1ccc(C2CCCCC2)cc1)Nc1cccc(C(=O)NCCN2CCOCC2)c1";"IC50";"'='";"280.0";"nM";"6.55";"";"";"UO_0000065";"14.54";"0.27";"2.11";"7.92";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087991";"";"0";"359.81";"0";"3.46";"5x,para isomer";"O=C(Nc1ccc(Cl)cc1)Nc1ccc(C(=O)N2CCOCC2)cc1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"21.52";"0.42";"4.28";"10.96";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1099390";"";"0";"472.49";"0";"2.96";"9b, meta isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(S(=O)(=O)NCCN2CCOCC2)c1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.05";"0.38";"6.04";"9.02";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL589860";"";"0";"457.38";"0";"4.15";"42";"CS(=O)(=O)c1ccccc1OC1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"'='";"4.9";"nM";"8.31";"";"";"UO_0000065";"18.17";"0.39";"4.16";"10.98";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL215908";"";"0";"453.58";"0";"3.59";"8e";"COC(=O)c1ccc(C(=O)N2CCC(CNC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1";"IC50";"'='";"1.5";"nM";"8.82";"";"";"UO_0000065";"19.45";"0.37";"5.23";"10.06";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214884";"";"0";"425.53";"0";"3.26";"7h";"O=C(NC1CCN(C(=O)c2ccccc2C(=O)O)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"160.0";"nM";"6.80";"";"";"UO_0000065";"15.97";"0.30";"3.54";"6.88";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3114602";"";"0";"412.53";"1";"5.46";"24";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2cccc(-c3ccccc3)c2)CC1";"IC50";"'='";"10.7";"nM";"7.97";"";"";"UO_0000065";"19.32";"0.35";"2.51";"19.17";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114593";"";"0";"350.46";"0";"4.10";"15";"Cc1cccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)c1";"IC50";"'='";"8.9";"nM";"8.05";"";"";"UO_0000065";"22.97";"0.42";"3.95";"19.37";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3327086";"";"0";"407.46";"0";"3.42";"31";"CCCCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"0.98";"nM";"9.01";"";"";"UO_0000065";"22.11";"0.46";"5.59";"11.47";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL70231";"";"0";"492.70";"1";"5.65";"35";"CCOC(=O)CCCCCCCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"14.21";"0.27";"1.35";"7.47";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL1933664";"";"0";"370.54";"0";"2.99";"14-47";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2cccs2)CC1";"IC50";"'='";"870.0";"nM";"6.06";"";"";"UO_0000065";"16.36";"0.34";"3.07";"9.12";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL2436562";"";"0";"433.89";"0";"4.78";"10";"O=C(Nc1ccc(Cl)cc1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"6.7";"nM";"8.17";"";"";"UO_0000065";"18.84";"0.37";"3.39";"15.53";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL308880";"";"0";"325.84";"0";"3.55";"10";"CCCCCNC(=O)CCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"32000.0";"nM";"4.50";"";"";"UO_0000065";"13.79";"0.28";"0.94";"6.40";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL308665";"";"0";"394.51";"0";"2.92";"31";"CCOC(=O)CCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"17.54";"0.34";"4.00";"7.38";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL63945";"";"0";"325.84";"0";"3.55";"14";"CCCCCCC(=O)NCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL242898";"";"0";"382.55";"0";"4.78";"9a";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2ccccc2)CC1";"IC50";"'='";"0.9";"nM";"9.05";"";"";"UO_0000065";"23.65";"0.44";"4.27";"17.96";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL243521";"";"0";"356.44";"0";"3.48";"29";"O=C(NCC#CCOc1ccc(F)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"42.0";"nM";"7.38";"";"";"UO_0000065";"20.70";"0.39";"3.90";"14.65";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245225";"";"0";"417.54";"1";"5.52";"22";"O=C(CC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2c(F)cccc2F)CC1";"IC50";"'='";"3.5";"nM";"8.46";"";"";"UO_0000065";"20.25";"0.38";"2.94";"22.06";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL222160";"";"0";"372.40";"0";"4.04";"c-FCUB";"O=C(Nc1ccc(C(=O)O)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"220.0";"nM";"6.66";"";"";"UO_0000065";"17.88";"0.34";"2.62";"7.59";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL221014";"";"0";"412.38";"1";"5.24";"c-FCTU";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"0.9";"nM";"9.05";"";"";"UO_0000065";"21.94";"0.43";"3.81";"15.18";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL244405";"";"0";"412.53";"0";"4.34";"16g";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"0.89";"nM";"9.05";"";"";"UO_0000065";"21.94";"0.41";"4.71";"10.32";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL395738";"";"0";"418.53";"1";"5.06";"9f";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2c(F)cccc2F)CC1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"21.40";"0.41";"3.90";"17.79";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL242459";"";"0";"412.53";"0";"4.34";"13g";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"21.54";"0.40";"4.55";"10.14";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL1098468";"";"0";"426.56";"0";"2.84";"5n, meta isomer";"O=C(Nc1cccc(C(=O)NCCN2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"62.0";"nM";"7.21";"";"";"UO_0000065";"16.90";"0.32";"4.37";"8.72";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL365939";"";"0";"218.30";"0";"3.14";"d-1";"O=C(Nc1ccccc1)NC1CCCCC1";"IC50";"'='";"1390.0";"nM";"5.86";"";"";"UO_0000065";"26.83";"0.50";"2.72";"14.24";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL192136";"";"0";"248.33";"0";"2.63";"e-1";"O=C(Nc1ccccc1CO)NC1CCCCC1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL233930";"ASTRAGALIN";"0";"448.38";"2";"-0.24";"21";"O=c1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12";"IC50";"'>'";"50000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1818407";"";"0";"320.33";"0";"4.94";"27";"CCCCCCCNC(=O)Nc1cccc(C(F)(F)F)c1F";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"29.34";"0.58";"4.46";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL3236512";"";"0";"292.20";"0";"0.66";"22";"O=C1C[C@H](C(=O)O)c2c1oc(=O)c1cc(O)c(O)c(O)c21";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL589375";"";"0";"463.28";"1";"5.65";"38";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccc(OC(F)(F)F)cc2)CC1";"EC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"16.72";"0.35";"2.09";"15.25";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL592257";"";"0";"371.40";"0";"4.07";"10";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC(N2CCCCC2)CC1";"IC50";"'>'";"3000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1078657";"";"0";"414.93";"1";"5.55";"2d";"O=C(O)CCCCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"20.01";"0.39";"2.75";"11.92";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL373902";"";"0";"395.50";"0";"1.38";"Table 2, r14c3";"O=C(CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)N[C@@H](CO)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL424747";"";"0";"439.62";"0";"3.14";"Table 2, r11c3";"CSCC[C@H](NC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL218354";"";"0";"379.50";"0";"2.40";"Table 2, r3c3";"C[C@H](NC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL376500";"";"0";"357.41";"0";"0.83";"Table 1, r11c1";"O=C(O)CC[C@H](NC(=O)CCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"24000.0";"nM";"4.62";"";"";"UO_0000065";"12.93";"0.25";"3.79";"3.19";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL222160";"";"0";"372.40";"0";"4.04";"8";"O=C(Nc1ccc(C(=O)O)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214505";"";"0";"405.54";"0";"2.59";"7b";"COC(=O)CCCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"2.7";"nM";"8.57";"";"";"UO_0000065";"21.13";"0.40";"5.98";"9.77";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL215025";"";"0";"333.48";"0";"2.51";"6a";"CC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"24.89";"0.47";"5.79";"13.51";"True";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL217758";"";"0";"373.42";"0";"2.81";"5d";"O=C(NC1CCN(C(=O)C(F)(F)F)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"23.99";"0.47";"6.15";"14.58";"True";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3765522";"";"0";"399.37";"1";"5.00";"25";"O=C(O)c1cccc(-c2ccc(C(=O)NCc3ccccc3C(F)(F)F)cc2)c1";"IC50";"'='";"1000.0";"nM";"6.00";"";"";"UO_0000065";"15.02";"0.28";"1.00";"9.04";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3765492";"";"0";"379.38";"0";"4.13";"16b";"CCOC(=O)CCc1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"18.34";"0.35";"2.83";"12.56";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3763887";"";"0";"425.42";"0";"4.91";"13b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccc(F)cc2C(F)(F)F)cc1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"16.27";"0.32";"2.01";"12.49";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL1375713";"";"0";"249.35";"0";"3.53";"10";"Cc1ccc(CNCCc2ccccc2F)s1";"IC50";"'='";"9000.0";"nM";"5.05";"";"";"UO_0000065";"20.24";"0.41";"1.52";"41.94";"False";"CHEMBL3406221";"Inhibition of C-terminal His6-tagged full-length human soluble epoxide hydrolase expressed in Escherichia coli BL21(DE3) cells pre-incubated for 15 mins before addition of PHOME substrate and measured 50 mins after substrate addition by microplate reader based fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400124";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3402238";"";"0";"248.33";"0";"2.55";"Fragment 7";"CC(C)(C)OC(=O)NC1CNc2ccccc2C1";"IC50";"'='";"580000.0";"nM";"3.24";"";"";"UO_0000065";"13.03";"0.25";"0.69";"6.43";"False";"CHEMBL3406221";"Inhibition of C-terminal His6-tagged full-length human soluble epoxide hydrolase expressed in Escherichia coli BL21(DE3) cells pre-incubated for 15 mins before addition of PHOME substrate and measured 50 mins after substrate addition by microplate reader based fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400124";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL568544";"";"0";"436.84";"0";"3.40";"34";"CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"17.91";"0.38";"4.42";"9.17";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL585949";"";"0";"436.84";"0";"3.40";"35";"CS(=O)(=O)c1cc(Cl)ccc1CNC(=O)c1ccc(OCCC(F)(F)F)nc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL11405";"";"0";"252.74";"0";"3.79";"160";"O=C(Nc1ccc(Cl)cc1)NC1CCCCC1";"IC50";"'='";"-0.4";"";"";"Non standard unit for type";"";"";"";"";"";"";"False";"CHEMBL809079";"Inhibitory activity against human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1136721";"1";"Scientific Literature";"J. Med. Chem.";"2003";"None"
"CHEMBL565841";"";"0";"358.75";"0";"4.00";"32";"O=C(NCc1ccc(Cl)cc1)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"77.0";"nM";"7.11";"";"";"UO_0000065";"19.83";"0.40";"3.11";"13.89";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3628777";"";"0";"613.58";"2";"7.59";"24";"CC(C)(C)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)P(=O)(OCC(F)(F)F)OCC(F)(F)F";"IC50";"'='";"3.8";"nM";"8.42";"";"";"UO_0000065";"13.72";"0.28";"0.83";"9.49";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3103808";"";"0";"266.34";"0";"0.95";"14";"CON(C)C(=O)C(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL265024";"";"0";"366.46";"0";"2.14";"29";"CCOC(=O)COC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC90";"'='";"9000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677486";"Tested for 90 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL3114610";"";"0";"428.92";"0";"4.08";"38";"O=C(O)Cc1ccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1";"IC50";"'='";"4.3";"nM";"8.37";"";"";"UO_0000065";"19.51";"0.38";"4.29";"10.61";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114603";"";"0";"412.53";"1";"5.46";"25";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccc(-c3ccccc3)cc2)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"19.20";"0.35";"2.46";"19.05";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114600";"";"0";"366.46";"0";"3.80";"22";"COc1ccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)cc1";"IC50";"'='";"10.2";"nM";"7.99";"";"";"UO_0000065";"21.81";"0.40";"4.19";"15.73";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL1632463";"";"0";"426.61";"0";"3.84";"25b";"O=C(Nc1cccc(OCCCCN2CCNCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"14.8";"nM";"7.83";"";"";"UO_0000065";"18.35";"0.34";"3.99";"11.93";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632462";"";"0";"440.63";"0";"4.18";"17a";"CN1CCN(CCCCOc2ccccc2NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"5290.0";"nM";"5.28";"";"";"UO_0000065";"11.98";"0.23";"1.10";"9.28";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL2398217";"";"0";"290.51";"1";"5.12";"8";"CCCCCCCCS(=O)(=O)CCCCCCCC";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL2400592";"Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonate) as substrate preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2398218";"";"0";"252.42";"0";"4.30";"2";"CCCCCCCC[S+]([O-])Cc1ccccc1";"IC50";"'='";"6800.0";"nM";"5.17";"";"";"UO_0000065";"20.47";"0.42";"0.87";"30.27";"False";"CHEMBL2400592";"Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonate) as substrate preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3233608";"";"0";"277.39";"0";"2.99";"9";"Cc1cc(-c2csc(N)n2)c(C)n1CC1CCCO1";"IC50";"'='";"195000.0";"nM";"3.71";"";"";"UO_0000065";"13.37";"0.27";"0.72";"6.99";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL437328";"";"0";"439.56";"0";"3.51";"8i";"O=C(NCC1CCN(C(=O)c2cccc(C(=O)O)c2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"43.0";"nM";"7.37";"";"";"UO_0000065";"16.76";"0.31";"3.86";"7.46";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL215121";"";"0";"453.58";"0";"3.59";"8d";"COC(=O)c1cccc(C(=O)N2CCC(CNC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c1";"IC50";"'='";"4.1";"nM";"8.39";"";"";"UO_0000065";"18.49";"0.35";"4.80";"9.56";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL384744";"";"0";"439.56";"0";"3.35";"7d";"COC(=O)c1cccc(C(=O)N2CCC(NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"20.38";"0.38";"5.61";"10.21";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3222114";"";"0";"424.55";"0";"3.08";"3b";"CC(=O)N1CCN(C(=O)c2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"46.3";"nM";"7.33";"";"";"UO_0000065";"17.28";"0.32";"4.25";"8.97";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL1079245";"";"0";"455.95";"0";"2.69";"2l";"O=C(CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1)NC1=NNNN1";"IC50";"'='";"1.4";"nM";"8.85";"";"";"UO_0000065";"19.42";"0.38";"6.16";"8.06";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078232";"";"0";"455.99";"0";"4.54";"2o";"O=C(CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1)N1CCOCC1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"17.76";"0.35";"3.56";"13.08";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078232";"";"0";"455.99";"0";"4.54";"2o";"O=C(CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1)N1CCOCC1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1079256";"";"0";"386.88";"0";"4.77";"entA-2b";"O=C(O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"FC";"'='";"2.5";"";"";"";"";"";"";"";"";"";"False";"CHEMBL1100163";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production in presence of 10% human serum";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL221015";"";"0";"396.38";"1";"5.36";"1{16}";"O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"22.51";"0.44";"3.56";"17.71";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL373655";"";"0";"470.64";"0";"3.45";"3{1}";"CN(C)c1cccc2c(S(=O)(=O)NCCNC(=O)NC34CC5CC(CC(C5)C3)C4)cccc12";"IC50";"'='";"30.0";"nM";"7.52";"";"";"UO_0000065";"15.98";"0.31";"4.07";"8.31";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL217942";"";"0";"412.55";"1";"6.58";"1{40}";"CC(C)c1cccc(C(C)C)c1NC(=O)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"5.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1078264";"";"0";"423.56";"1";"6.10";"1i";"CC1(c2ccccc2)CCCN(C(=O)NCc2ccc(-c3ccc4[nH]ccc4c3)cc2)C1";"IC50";"'='";"3000.0";"nM";"5.52";"";"";"UO_0000065";"13.04";"0.24";"-0.58";"11.47";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1078353";"";"0";"337.47";"0";"3.78";"1k";"CC1(c2ccccc2)CCCN(C(=O)NCCCc2cccnc2)C1";"IC50";"'='";"8000.0";"nM";"5.10";"";"";"UO_0000065";"15.10";"0.28";"1.32";"11.27";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1078354";"";"0";"362.48";"0";"3.87";"1l";"CC1(c2ccccc2)CCCN(C(=O)NCCc2ccc3nc[nH]c3c2)C1";"IC50";"'='";"13000.0";"nM";"4.89";"";"";"UO_0000065";"13.48";"0.25";"1.02";"8.01";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL245159";"";"0";"413.56";"0";"3.88";"29";"O=C(Nc1ccc(OCCCN2CCOCC2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"21.49";"0.40";"5.01";"14.14";"True";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL242655";"";"0";"396.57";"0";"3.49";"15";"CCOCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"19.80";"0.38";"4.36";"11.41";"True";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245142";"";"0";"336.52";"0";"4.24";"8";"CCCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"4.1";"nM";"8.39";"";"";"UO_0000065";"24.92";"0.48";"4.15";"16.65";"True";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL221737";"";"0";"407.28";"1";"5.10";"1{14}";"O=C(Nc1ccc(Br)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"22.64";"0.50";"4.12";"18.31";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3263289";"";"0";"498.76";"1";"5.58";"1c";"O=C(NCCCCCCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2";"Ki";"'='";"3.4";"nM";"8.47";"";"";"UO_0000065";"16.98";"0.32";"2.89";"10.29";"False";"CHEMBL3270577";"Displacement of ACPU from recombinant human soluble epoxide hydrolase after 1.5 hrs by FRET assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL386044";"";"0";"347.55";"0";"3.77";"4c";"CCCCN1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"610.0";"nM";"6.21";"";"";"UO_0000065";"17.88";"0.34";"2.44";"14.01";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1632478";"";"0";"440.59";"0";"3.32";"27b";"CC(=O)N1CCN(CCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"6.0";"nM";"8.22";"";"";"UO_0000065";"18.66";"0.35";"4.90";"11.12";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632477";"";"0";"482.67";"0";"4.49";"30b";"CC(=O)N1CCN(CCCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"2.8";"nM";"8.55";"";"";"UO_0000065";"17.72";"0.33";"4.06";"11.57";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1817677";"";"0";"332.88";"0";"4.99";"22";"Cc1ccc(NC(=O)NCC23CC4CC(CC(C4)C2)C3)cc1Cl";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"28.23";"0.56";"4.41";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL559101";"";"0";"310.40";"0";"2.79";"1e";"O=C(NC1CC1c1ccccc1)N1CCC(n2cccn2)CC1";"IC50";"'='";"2439.0";"nM";"5.61";"";"";"UO_0000065";"18.08";"0.33";"2.82";"11.19";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL561379";"";"0";"312.37";"0";"2.51";"1g";"O=C(NC1CC1c1ccccc1)N1CCC(c2nnco2)CC1";"IC50";"'='";"240.0";"nM";"6.62";"";"";"UO_0000065";"21.19";"0.39";"4.11";"9.29";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL561788";"";"0";"456.47";"1";"5.20";"2a";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccccc3C(F)(F)F)no2)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"17.87";"0.34";"2.95";"11.44";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL559279";"";"0";"348.53";"1";"6.71";"25";"CCCCCc1ccc(CCCC/C=C\CCCCCCC(=O)O)o1";"IC50";"'='";"7147.0";"nM";"5.15";"";"";"UO_0000065";"14.76";"0.28";"-1.56";"10.20";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL3099593";"";"0";"236.28";"0";"1.10";"o";"CCCCNC(=O)Nc1ccc(C(N)=O)cn1";"Activity";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3102106";"Binding affinity to soluble epoxide hydrolase (unknown origin) at 400 uM by STD-NMR assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL195542";"";"0";"326.82";"0";"3.94";"11";"CCCCCOC(=O)CCCOC(=O)Cc1cccc(Cl)c1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL2031798";"";"0";"336.38";"0";"4.38";"3";"O=C(Nc1cccc(OC(F)F)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.6";"nM";"8.59";"";"";"UO_0000065";"25.52";"0.49";"4.21";"17.05";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031800";"";"0";"368.40";"0";"4.80";"5";"COc1cc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc(C(F)(F)F)c1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"23.80";"0.46";"3.97";"17.41";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL477237";"";"0";"356.47";"0";"3.88";"19";"COC(=O)CCc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"24.40";"0.46";"4.82";"12.90";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL589376";"";"0";"404.30";"0";"4.62";"39";"N#Cc1ccccc1OC1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"'='";"3.9";"nM";"8.41";"";"";"UO_0000065";"20.80";"0.43";"3.79";"12.87";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1933496";"";"0";"370.56";"0";"3.20";"14-5";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)C2CCCCC2)CC1";"IC50";"'='";"950.0";"nM";"6.02";"";"";"UO_0000065";"16.25";"0.33";"2.82";"9.06";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933663";"";"0";"414.57";"0";"4.08";"14-46";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2cccc3ccccc23)CC1";"IC50";"'='";"35.0";"nM";"7.46";"";"";"UO_0000065";"17.98";"0.35";"3.38";"11.22";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1507203";"";"0";"342.48";"0";"3.69";"15-5";"Cc1ccc(C(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"950.0";"nM";"6.02";"";"";"UO_0000065";"17.58";"0.33";"2.33";"12.19";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1314245";"";"0";"362.90";"0";"4.03";"15-10";"O=C(NC1CCCCCC1)C1CCN(C(=O)c2ccc(Cl)cc2)CC1";"IC50";"'='";"1100.0";"nM";"5.96";"";"";"UO_0000065";"16.42";"0.33";"1.93";"12.06";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL496189";"";"0";"376.46";"0";"3.75";"rac-1a";"O=C1CC2(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)Oc2ccccc21";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"22.64";"0.42";"4.77";"14.53";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1077781";"";"0";"372.85";"0";"4.38";"2a";"O=C(O)CC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"52.0";"nM";"7.28";"";"";"UO_0000065";"19.54";"0.38";"2.90";"10.46";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1271711";"";"0";"410.36";"0";"4.00";"24";"O=C(Nc1cnc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cn1)c1ccccc1";"IC50";"'='";"28.0";"nM";"7.55";"";"";"UO_0000065";"18.41";"0.34";"3.55";"8.82";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL436774";"AR9281";"2";"319.45";"0";"2.27";"APAU";"CC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"25.53";"0.48";"5.88";"13.27";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933498";"";"0";"382.50";"0";"3.07";"14-8";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccccc2F)CC1";"IC50";"'='";"78.0";"nM";"7.11";"";"";"UO_0000065";"18.58";"0.37";"4.04";"10.69";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933517";"";"0";"396.53";"0";"3.37";"14-29";"Cc1cc(F)ccc1S(=O)(=O)N1CCC(C(=O)NC2CCCCCC2)CC1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"19.53";"0.39";"4.37";"11.65";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933676";"";"0";"362.90";"0";"4.03";"15-9";"O=C(NC1CCCCCC1)C1CCN(C(=O)c2ccccc2Cl)CC1";"IC50";"'='";"200.0";"nM";"6.70";"";"";"UO_0000065";"18.46";"0.37";"2.67";"13.56";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL302704";"";"0";"450.62";"0";"4.48";"33";"CCOC(=O)CCCCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"15.44";"0.30";"2.48";"7.42";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL477238";"";"0";"342.44";"0";"3.49";"18";"COC(=O)Cc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"4.4";"nM";"8.36";"";"";"UO_0000065";"24.40";"0.46";"4.87";"12.39";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031924";"";"0";"440.58";"0";"4.82";"60";"CCOC(=O)c1ccc(O[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"19.96";"0.38";"3.98";"11.47";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2336316";"";"0";"576.02";"2";"7.09";"8n";"COc1cc(-c2nc3ccc(Cl)cn3c2NC(C)C)ccc1OCCCNC(=O)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"104.0";"nM";"6.98";"";"";"UO_0000065";"12.12";"0.24";"-0.11";"7.85";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2336308";"";"0";"615.63";"2";"7.38";"8f";"COc1cc(-c2nc3ccc(F)cn3c2NC2CCCCC2)ccc1OCCCNC(=O)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"82.0";"nM";"7.09";"";"";"UO_0000065";"11.51";"0.22";"-0.29";"7.22";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2336304";"";"0";"595.67";"2";"7.67";"8b";"COc1cc(-c2nc3ccc(C)cn3c2NC2CCCCC2)ccc1OCCCNC(=O)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"44.0";"nM";"7.36";"";"";"UO_0000065";"12.35";"0.23";"-0.31";"8.27";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2336309";"";"0";"599.63";"2";"7.50";"8g";"COc1cc(-c2nc3ccc(F)cn3c2NC2CCCCC2)ccc1OCCCNC(=O)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"52.0";"nM";"7.28";"";"";"UO_0000065";"12.15";"0.23";"-0.22";"8.19";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2336737";"";"0";"532.09";"2";"7.11";"4b";"Cc1ccc2nc(-c3ccc(OCC4CCN(C(=O)Nc5ccc(Cl)cc5)CC4)cc3)c(NC(C)C)n2c1";"IC50";"'='";"65.0";"nM";"7.19";"";"";"UO_0000065";"13.51";"0.26";"0.08";"10.14";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL1668933";"";"0";"329.32";"0";"2.84";"14l";"CC(=O)N1CCC(NC(=O)Nc2cccc(C(F)(F)F)c2)CC1";"IC50";"'='";"226.0";"nM";"6.65";"";"";"UO_0000065";"20.18";"0.39";"3.81";"10.82";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"32";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"21.71";"0.42";"3.28";"10.87";"True";"CHEMBL2174521";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2169824";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2011";"None"
"CHEMBL1271659";"";"0";"410.36";"0";"4.00";"21";"O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)nn1)c1ccccc1";"IC50";"'='";"8.8";"nM";"8.06";"";"";"UO_0000065";"19.63";"0.37";"4.06";"9.41";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1271659";"";"0";"410.36";"0";"4.00";"21";"O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)nn1)c1ccccc1";"IC50";"'='";"83.0";"nM";"7.08";"";"";"UO_0000065";"17.26";"0.32";"3.08";"8.27";"False";"CHEMBL1273200";"Displacement of [3H]-cDPPO from human Ephx2 by cell-based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL6";"INDOMETHACIN";"4";"357.79";"0";"3.93";"3";"COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1";"IC50";"'>'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766292";"";"0";"530.53";"2";"5.16";"11d";"CS(=O)(=O)c1ccc(-n2nc(CNC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccccc2)cc1";"IC50";"'='";"6.0";"nM";"8.22";"";"";"UO_0000065";"15.50";"0.30";"3.06";"8.04";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL562105";"";"0";"366.55";"0";"4.76";"11";"CCCCCN(C)C(=O)N(C)CCCCCCCC#CCCCC(=O)O";"IC50";"'='";"11064.0";"nM";"4.96";"";"";"UO_0000065";"13.52";"0.26";"0.20";"8.14";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL589135";"";"0";"379.29";"0";"4.75";"32";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccccc2)CC1";"IC50";"'='";"4.3";"nM";"8.37";"";"";"UO_0000065";"22.06";"0.46";"3.62";"20.13";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1099360";"";"0";"371.48";"0";"3.15";"5ab,para isomer";"COCCNC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"54.0";"nM";"7.27";"";"";"UO_0000065";"19.56";"0.37";"4.12";"9.15";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088228";"";"0";"470.52";"0";"4.06";"9a, meta isomer";"CC(C)N1CCN(S(=O)(=O)c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)CC1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"18.11";"0.36";"4.46";"10.43";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1818400";"";"0";"264.41";"0";"3.30";"19";"CCCCCNC(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"6.4";"nM";"8.19";"";"";"UO_0000065";"30.99";"0.59";"4.89";"19.92";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL478146";"";"0";"396.54";"0";"3.16";"5f, meta isomer";"CN1CCN(C(=O)c2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"36.0";"nM";"7.44";"";"";"UO_0000065";"18.77";"0.35";"4.28";"11.51";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL354676";"DIPHENYLUREA";"0";"212.25";"0";"3.33";"Figure 2B, R1C1";"O=C(Nc1ccccc1)Nc1ccccc1";"IC50";"'='";"390.0";"nM";"6.41";"";"";"UO_0000065";"30.20";"0.55";"3.08";"15.58";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818411";"";"0";"340.41";"0";"4.22";"31";"Fc1ccc(NC(=S)NC2C3CC4CC(C3)CC2C4)c(F)c1F";"IC50";"'='";"4.8";"nM";"8.32";"";"";"UO_0000065";"24.44";"0.49";"4.10";"34.58";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818390";"";"0";"300.32";"0";"4.34";"7";"O=C(Nc1ccc(F)c(F)c1F)NC1CCCCCCC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"31.29";"0.61";"5.06";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL496189";"";"0";"376.46";"0";"3.75";"rac-1a";"O=C1CC2(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)Oc2ccccc21";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"21.14";"0.39";"4.21";"13.57";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL483876";"";"0";"380.46";"0";"4.25";"rac-1g";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CCc3cc(F)ccc3O2)CC1";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL495792";"";"0";"456.55";"0";"4.15";"rac-1c";"Cn1nccc1-c1ccc2c(c1)C(=O)CC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"18.39";"0.34";"4.25";"10.98";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1079246";"";"0";"399.92";"0";"4.43";"2m";"CNC(=O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1079061";"";"0";"512.53";"2";"6.68";"3g";"O=C(O)CCC1(c2ccc(-c3ccccc3)cc2)CCCN(C(=O)Nc2ccc(OC(F)(F)F)cc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1096113";"";"0";"393.37";"0";"3.82";"5y, meta isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(C(=O)N2CCOCC2)c1";"IC50";"'='";"9.0";"nM";"8.05";"";"";"UO_0000065";"20.45";"0.39";"4.23";"11.38";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1086982";"";"0";"438.43";"0";"4.31";"6c,para isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(C(=O)NCCN2CCCC2)c(F)c1";"IC50";"'='";"19.0";"nM";"7.72";"";"";"UO_0000065";"17.61";"0.34";"3.41";"10.51";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1258449";"";"0";"309.80";"0";"2.86";"30";"CCC(=O)N1CCC(NC(=O)Nc2cccc(Cl)c2)CC1";"IC50";"'='";"21.0";"nM";"7.68";"";"";"UO_0000065";"24.78";"0.50";"4.82";"12.50";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258219";"";"0";"319.36";"0";"1.91";"22";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"330.0";"nM";"6.48";"";"";"UO_0000065";"20.30";"0.38";"4.57";"6.56";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL469373";"";"0";"419.52";"0";"3.29";"8-24";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NNc3ccc(F)cc3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL504294";"";"0";"365.28";"0";"2.28";"6-12";"CS(=O)(=O)N1CCC(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"Inhibition";"'='";"45.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL513535";"";"0";"502.99";"2";"5.00";"8-32";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)c(C(F)(F)F)c3)CC2)c(C)c1";"Inhibition";"'='";"96.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL513013";"";"0";"433.38";"1";"5.09";"6-27";"Cc1cc(C)c(C(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL513416";"";"0";"512.35";"1";"4.45";"6-32";"COc1cc(OC(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c([N+](=O)[O-])cc1OC";"IC50";"'='";"75.3";"nM";"7.12";"";"";"UO_0000065";"13.90";"0.29";"2.67";"5.92";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL387034";"";"0";"367.54";"0";"3.92";"3d";"O=C(NC1CCN(Cc2ccccc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"21.77";"0.40";"4.08";"18.03";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL511958";"";"0";"472.35";"0";"3.62";"6-2";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL191767";"";"0";"336.52";"0";"4.24";"6";"CCCCCOCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"4.4";"nM";"8.36";"";"";"UO_0000065";"24.83";"0.48";"4.12";"16.59";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL511617";"";"0";"389.50";"0";"4.99";"20a";"O=C(Nc1ccc(OCc2ccccc2)cc1)C(=O)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"210.0";"nM";"6.68";"";"";"UO_0000065";"17.14";"0.31";"1.69";"12.05";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3233603";"";"0";"204.27";"0";"2.61";"1";"CC(NC(=O)Nc1ccccc1)C1CC1";"IC50";"'='";"7400.0";"nM";"5.13";"";"";"UO_0000065";"25.12";"0.47";"2.52";"12.47";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL550652";"";"0";"325.42";"0";"2.26";"1c";"Cn1cnnc1C1CCN(C(=O)NC2CC2c2ccccc2)CC1";"IC50";"'='";"8400.0";"nM";"5.08";"";"";"UO_0000065";"15.60";"0.29";"2.82";"8.05";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL563732";"";"0";"311.39";"0";"2.18";"1d";"O=C(NC1CC1c1ccccc1)N1CCC(n2cncn2)CC1";"IC50";"'='";"1100.0";"nM";"5.96";"";"";"UO_0000065";"19.14";"0.35";"3.78";"9.45";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL584611";"";"0";"347.22";"1";"5.00";"7ff";"FC(F)(F)c1ccc(Nc2noc3c(C(F)(F)F)cccc23)cn1";"IC50";"'='";"74.0";"nM";"7.13";"";"";"UO_0000065";"20.54";"0.41";"2.13";"14.00";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1632465";"";"0";"468.64";"0";"4.10";"29b";"CC(=O)N1CCN(CCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"2.7";"nM";"8.57";"";"";"UO_0000065";"18.28";"0.34";"4.47";"11.59";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1629744";"";"0";"468.64";"0";"4.10";"29a";"CC(=O)N1CCN(CCCCOc2ccccc2NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"3150.0";"nM";"5.50";"";"";"UO_0000065";"11.74";"0.22";"1.40";"7.44";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632461";"";"0";"426.61";"0";"3.84";"25a";"O=C(Nc1ccccc1OCCCCN1CCNCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"72770.0";"nM";"4.14";"";"";"UO_0000065";"9.70";"0.18";"0.30";"6.31";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL396980";"";"0";"450.54";"0";"4.04";"16";"O=C(NCCCCCOCCOCCOCC(F)(F)F)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.4";"nM";"8.85";"";"";"UO_0000065";"19.65";"0.39";"4.81";"12.87";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245144";"";"0";"336.52";"0";"4.24";"10";"CCCOCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.7";"nM";"8.43";"";"";"UO_0000065";"25.06";"0.48";"4.19";"16.74";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL1668934";"";"0";"345.32";"0";"2.72";"TPAU";"CC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"T1/2";"'='";"0.07333";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL512131";"";"0";"433.40";"0";"3.98";"6-14";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)C2CCCCC2)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512704";"";"0";"504.70";"2";"5.35";"8-3";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCCC(c3ccccc3)c3ccccc3)CC2)c(C)c1";"IC50";"'='";"35.0";"nM";"7.46";"";"";"UO_0000065";"14.77";"0.28";"2.11";"11.22";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471452";"";"0";"444.60";"0";"3.38";"8-26";"COc1ccc(CCNC(=O)C2CCN(S(=O)(=O)c3c(C)cc(C)cc3C)CC2)cc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470616";"";"0";"434.99";"0";"3.98";"8-28";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccccc3Cl)CC2)c(C)c1";"IC50";"'='";"27.4";"nM";"7.56";"";"";"UO_0000065";"17.38";"0.36";"3.58";"11.38";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512872";"";"0";"435.98";"0";"3.81";"8-20";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NNc3ccccc3Cl)CC2)c(C)c1";"IC50";"'='";"33.6";"nM";"7.47";"";"";"UO_0000065";"17.14";"0.35";"3.66";"9.52";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512842";"";"0";"406.59";"0";"3.71";"8-46";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCC(C)CC3)CC2)c(C)c1";"IC50";"'='";"39.6";"nM";"7.40";"";"";"UO_0000065";"18.21";"0.36";"3.69";"11.13";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL215025";"";"0";"333.48";"0";"2.51";"AMAU";"CC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"24.89";"0.47";"5.79";"13.51";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL511958";"";"0";"472.35";"0";"3.62";"6-2";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CC1";"Inhibition";"'='";"47.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469763";"";"0";"472.35";"0";"3.62";"6-4";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2cccc([N+](=O)[O-])c2)CC1";"Inhibition";"'='";"21.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470823";"";"0";"489.85";"0";"4.98";"6-23";"Cc1cc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C)cc1Cl";"Inhibition";"'='";"97.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3322803";"";"0";"417.62";"0";"3.62";"8";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)NS(C)(=O)=O";"IC50";"'='";"71.0";"nM";"7.15";"";"";"UO_0000065";"17.12";"0.35";"3.53";"6.85";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322805";"";"0";"420.44";"0";"4.33";"10";"CCCCCNC(=O)NCCCC/C=C\CCCCCCP(=O)([O-])[O-].[Na+].[Na+]";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322822";"";"0";"396.60";"0";"4.54";"27";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1nsc(=O)[nH]1";"IC50";"'='";"231.0";"nM";"6.64";"";"";"UO_0000065";"16.73";"0.34";"2.10";"7.64";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3103806";"";"0";"356.47";"0";"2.61";"12";"O=C(NOCCCc1ccccc1)C(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"550.0";"nM";"6.26";"";"";"UO_0000065";"17.56";"0.33";"3.65";"9.28";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL1632456";"";"0";"412.58";"0";"3.45";"24b";"O=C(Nc1cccc(OCCCN2CCNCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"27.2";"nM";"7.57";"";"";"UO_0000065";"18.34";"0.34";"4.12";"11.53";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL245150";"";"0";"426.60";"0";"3.12";"18";"COCCOCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"17.90";"0.35";"4.52";"9.79";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL397197";"";"0";"266.38";"0";"2.03";"5";"O=C(NCCCCO)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"531.0";"nM";"6.28";"";"";"UO_0000065";"23.56";"0.45";"4.24";"10.23";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL1088688";"";"0";"415.49";"0";"2.61";"5d, meta isomer";"O=C(O)COCCNC(=O)c1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"130.0";"nM";"6.89";"";"";"UO_0000065";"16.57";"0.31";"4.28";"5.90";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL242255";"";"0";"276.42";"0";"3.59";"Figure 2B, R2C1";"O=C(NC1CCCCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"31.47";"0.59";"5.11";"21.15";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818393";"";"0";"295.39";"0";"3.50";"10";"N#Cc1ccc(NC(=O)NC2C3CC4CC(C3)CC2C4)cc1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"30.33";"0.56";"5.46";"13.80";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1632468";"";"0";"468.64";"0";"4.10";"29c";"CC(=O)N1CCN(CCCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"17.40";"0.33";"4.05";"11.03";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632484";"";"0";"504.70";"1";"3.51";"40";"CS(=O)(=O)N1CCN(CCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"17.83";"0.35";"5.49";"9.89";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1818419";"";"0";"280.41";"0";"2.68";"40";"CCCOCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"242.6";"nM";"6.62";"";"";"UO_0000065";"23.59";"0.45";"3.94";"13.14";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818412";"";"0";"325.33";"0";"4.48";"32";"O=C(Nc1ccc(F)c(F)c1F)OC1C2CC3CC(C2)CC1C3";"IC50";"'='";"463.8";"nM";"6.33";"";"";"UO_0000065";"19.47";"0.38";"1.85";"16.52";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818401";"";"0";"278.44";"0";"3.69";"20";"CCCCCCNC(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"32.32";"0.61";"5.31";"21.88";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1632473";"";"0";"398.55";"0";"3.06";"23b";"O=C(Nc1cccc(OCCN2CCNCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"67.1";"nM";"7.17";"";"";"UO_0000065";"18.00";"0.34";"4.11";"10.93";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL218402";"";"0";"540.67";"2";"2.44";"Table 3,r7c1";"O=C(CCCCCNC(=O)NC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)O";"IC50";"'='";"5500.0";"nM";"5.26";"";"";"UO_0000065";"9.73";"0.18";"2.82";"3.18";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219597";"";"0";"403.52";"0";"2.99";"Table 3,r1c1";"O=C(CCCCCNC(=O)NC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)O";"IC50";"'='";"1000.0";"nM";"6.00";"";"";"UO_0000065";"14.87";"0.28";"3.01";"5.58";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL386455";"";"0";"391.51";"0";"2.36";"8f";"O=C(O)CCC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"170.0";"nM";"6.77";"";"";"UO_0000065";"17.29";"0.33";"4.41";"6.86";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL2348390";"";"0";"291.28";"0";"1.89";"5a";"O=c1[nH]c2c(OS(=O)(=O)c3ccccc3)cccc2o1";"Inhibition";"'='";"35.97";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348188";"";"0";"289.67";"0";"2.99";"4b";"O=C(Oc1cccc2oc(=O)[nH]c12)c1ccccc1Cl";"Inhibition";"'='";"30.81";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392730";"";"0";"302.42";"0";"3.30";"42";"CCn1nc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1C";"IC50";"'='";"2512.0";"nM";"5.60";"";"";"UO_0000065";"18.52";"0.35";"2.30";"9.50";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392729";"";"0";"288.40";"0";"2.99";"41";"CCn1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)n1";"IC50";"'='";"884.0";"nM";"6.05";"";"";"UO_0000065";"20.99";"0.39";"3.06";"10.27";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392722";"";"0";"291.42";"0";"3.54";"34";"Cc1cnc(NC(=O)NC23CC4CC(CC(C4)C2)C3)s1";"IC50";"'='";"116.0";"nM";"6.94";"";"";"UO_0000065";"23.80";"0.47";"3.40";"12.84";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392755";"";"0";"261.32";"0";"2.76";"22";"O=C(Nc1ccon1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"46.0";"nM";"7.34";"";"";"UO_0000065";"28.08";"0.53";"4.58";"10.93";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392745";"";"0";"441.56";"0";"3.68";"11";"Cc1ccnc(NS(=O)(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)n1";"IC50";"'='";"17.0";"nM";"7.77";"";"";"UO_0000065";"17.60";"0.34";"4.09";"6.87";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392743";"";"0";"430.53";"0";"3.87";"9";"Cc1cc(NS(=O)(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)no1";"IC50";"'='";"292.0";"nM";"6.54";"";"";"UO_0000065";"15.18";"0.30";"2.66";"5.77";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL66319";"";"0";"380.49";"0";"2.53";"30";"CCOC(=O)CCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"540.0";"nM";"6.27";"";"";"UO_0000065";"16.47";"0.32";"3.74";"6.69";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL3222118";"";"0";"482.63";"0";"4.47";"4c";"CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"19.27";"0.36";"4.83";"10.22";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL222080";"";"0";"298.43";"0";"4.02";"4{1}";"C[C@@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)c1ccccc1";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"23.46";"0.43";"2.98";"17.02";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL66663";"";"0";"324.85";"0";"4.78";"8";"CCCCCCC(=O)CCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"2100.0";"nM";"5.68";"";"";"UO_0000065";"17.48";"0.35";"0.90";"9.76";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL242459";"";"0";"412.53";"0";"4.34";"13g";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"21.09";"0.40";"4.36";"9.92";"False";"CHEMBL894939";"Inhibition of human sEH by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL2336312";"";"0";"571.60";"2";"6.63";"8j";"COc1cc(-c2nc3ccc(C)cn3c2NC(C)C)ccc1OCCCNC(=O)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"147.0";"nM";"6.83";"";"";"UO_0000065";"11.95";"0.23";"0.20";"6.96";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL66709";"";"0";"326.82";"0";"3.98";"11";"CCCCCCC(=O)OCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"26000.0";"nM";"4.58";"";"";"UO_0000065";"14.03";"0.28";"0.61";"6.80";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL550648";"";"0";"533.63";"2";"5.48";"Taisho, WO2007043653";"CCCCn1c(-c2cc(OC)c(OC)c(OC)c2)nc2cc(C(=O)NCc3cccc(OC)c3OC)ccc21";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"16.87";"0.32";"3.52";"9.67";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL552402";"";"0";"361.45";"0";"4.27";"1j";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc3ccccc3o2)CC1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"22.40";"0.41";"3.83";"13.87";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL1079246";"";"0";"399.92";"0";"4.43";"2m";"CNC(=O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"20.76";"0.40";"3.87";"13.51";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL242257";"";"0";"292.42";"0";"2.56";"8";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](O)CC1";"IC50";"'='";"76.0";"nM";"7.12";"";"";"UO_0000065";"24.35";"0.46";"4.56";"11.60";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL243522";"";"0";"384.54";"1";"5.20";"36";"O=C(NC1CCC(Cc2ccc(F)cc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.5";"nM";"8.60";"";"";"UO_0000065";"22.37";"0.42";"3.40";"20.91";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL244407";"";"0";"412.53";"0";"4.34";"16k";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccccc2C(=O)O)CC1";"IC50";"'='";"330.0";"nM";"6.48";"";"";"UO_0000065";"15.71";"0.30";"2.14";"7.39";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245255";"";"0";"416.99";"1";"5.44";"9d";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2ccccc2Cl)CC1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"20.86";"0.41";"3.26";"17.27";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL242900";"";"0";"416.99";"1";"5.44";"3d";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2ccccc2Cl)CC1";"IC50";"'='";"2.7";"nM";"8.57";"";"";"UO_0000065";"20.55";"0.40";"3.13";"17.01";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL572206";"";"0";"358.75";"0";"4.00";"31";"O=C(NCc1ccccc1Cl)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"21.0";"nM";"7.68";"";"";"UO_0000065";"21.40";"0.44";"3.68";"14.99";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL579017";"";"0";"260.34";"0";"4.36";"6d";"c1ccc(CNc2cc(-c3ccccc3)ccn2)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL386384";"";"0";"425.53";"0";"3.26";"7j";"O=C(NC1CCN(C(=O)c2ccc(C(=O)O)cc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.3";"nM";"8.48";"";"";"UO_0000065";"19.93";"0.37";"5.22";"8.59";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214943";"";"0";"333.48";"0";"2.66";"5b";"CCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"3.2";"nM";"8.49";"";"";"UO_0000065";"25.47";"0.48";"5.83";"13.83";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL218113";"";"0";"534.72";"1";"3.23";"Table 3,r10c1";"CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"870.0";"nM";"6.06";"";"";"UO_0000065";"11.33";"0.22";"2.83";"4.44";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219094";"";"0";"308.42";"0";"2.90";"Table 2, r1c3";"O=C(O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL387334";"";"0";"385.46";"0";"1.61";"Table 1, r18c1";"O=C(O)CC[C@H](NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219974";"";"0";"270.37";"0";"2.35";"Table 1, r16c1";"COC(=O)CCCCCNC(=O)NC1CCCCC1";"IC50";"'='";"3200.0";"nM";"5.50";"";"";"UO_0000065";"20.32";"0.39";"3.14";"8.15";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL386164";"";"0";"365.43";"0";"0.93";"Table 1, r12c1";"O=C(CCCNC(=O)NC1CCCCC1)N[C@@H](Cc1cnc[nH]1)C(=O)O";"IC50";"'='";"30000.0";"nM";"4.52";"";"";"UO_0000065";"12.38";"0.24";"3.59";"3.32";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL438273";"";"0";"504.63";"2";"1.86";"Table 3,r14c1";"CC(O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"1300.0";"nM";"5.89";"";"";"UO_0000065";"11.66";"0.22";"4.03";"3.75";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL66498";"";"0";"326.87";"0";"4.57";"6";"CCCCCCC(O)CCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"3100.0";"nM";"5.51";"";"";"UO_0000065";"16.85";"0.34";"0.94";"8.98";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL192470";"";"0";"251.76";"0";"4.25";"b-2";"O=C(CC1CCCCC1)Nc1cccc(Cl)c1";"IC50";"'='";"2100.0";"nM";"5.68";"";"";"UO_0000065";"22.55";"0.46";"1.43";"19.51";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL222161";"";"0";"386.42";"0";"4.12";"9";"COC(=O)c1cccc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc(F)cc3)CC2)c1";"Inhibition";"'='";"72.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL245142";"";"0";"336.52";"0";"4.24";"73";"CCCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"4.1";"nM";"8.39";"";"";"UO_0000065";"24.92";"0.48";"4.15";"16.65";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2029374";"";"0";"274.41";"0";"4.44";"84";"CC(C)(C)c1ccc(NC(=O)NC2CCCCC2)cc1";"IC50";"'='";"3.9";"nM";"8.41";"";"";"UO_0000065";"30.64";"0.57";"3.97";"20.44";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL427695";"";"0";"398.55";"0";"4.65";"122";"COc1ccc(O[C@H]2CC[C@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"22.83";"0.43";"4.45";"15.27";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3270681";"Inhibition of human recombinant soluble epoxide hydrolase assessed as conversion of 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid to fluorescent 6-methoxy-naphthaldehyde at 10 uM after 10 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259773";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1632482";"";"0";"522.61";"1";"4.64";"38";"O=C(Nc1cccc(OCCCCN2CCN(C(=O)C(F)(F)F)CC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"16.73";"0.32";"4.10";"11.83";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632485";"";"0";"620.79";"2";"5.42";"41";"COc1cc(C(=O)N2CCN(CCCCOc3cccc(NC(=O)NC45CC6CC(CC(C6)C4)C5)c3)CC2)cc(OC)c1OC";"IC50";"'='";"9.6";"nM";"8.02";"";"";"UO_0000065";"12.92";"0.24";"2.60";"7.89";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL251254";"HYPEROSIDE";"0";"464.38";"2";"-0.54";"16";"O=c1c(O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12";"IC50";"'='";"21760.0";"nM";"4.66";"";"";"UO_0000065";"10.04";"0.19";"5.20";"2.21";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1632471";"";"0";"540.71";"2";"5.02";"35";"CC(C)(C)OC(=O)N1CCN(C(=O)CCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"21.5";"nM";"7.67";"";"";"UO_0000065";"14.18";"0.27";"2.65";"7.65";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL70231";"";"0";"492.70";"1";"5.65";"35";"CCOC(=O)CCCCCCCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC90";"'='";"1200.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677486";"Tested for 90 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL438983";"";"0";"386.42";"0";"4.12";"7";"COC(=O)c1ccc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc(F)cc3)CC2)cc1";"Inhibition";"'='";"62.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3763373";"";"0";"325.41";"0";"3.58";"3c";"CCC(Cc1ccc(C(=O)NCc2ccccc2C)cc1)C(=O)O";"Inhibition";"'='";"25.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3767858";"Inhibition of human recombinant sEH using PHOME as substrate at 10 uM preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL1221722";"";"0";"480.38";"2";"-0.83";"19";"O=c1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL233930";"ASTRAGALIN";"0";"448.38";"2";"-0.24";"21";"O=c1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1433300";"";"0";"269.39";"0";"3.52";"17";"O=C(NCc1ccccc1)C12CC3CC(CC(C3)C1)C2";"IC50";"'>'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3103786";"";"0";"427.55";"0";"2.89";"24";"CON(C)C(=O)C(=O)N(C)c1ccc(CNC(=O)CC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"7.9";"nM";"8.10";"";"";"UO_0000065";"18.95";"0.36";"5.21";"10.26";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL374730";"";"0";"362.83";"0";"4.99";"1{13}";"O=C(Nc1ccc(Cl)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"25.23";"0.50";"4.16";"18.18";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL514369";"";"0";"370.49";"0";"4.27";"24";"COC(=O)CCCc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"3.1";"nM";"8.51";"";"";"UO_0000065";"22.97";"0.43";"4.24";"12.62";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1818420";"";"0";"384.52";"1";"6.18";"41";"CC(C)CCOc1ccc(NC(=O)Nc2ccc(OCCC(C)C)cc2)cc1";"IC50";"'='";"6.5";"nM";"8.19";"";"";"UO_0000065";"21.29";"0.40";"2.01";"13.74";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL219490";"";"0";"516.68";"1";"3.52";"Table 3,r8c1";"CCC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"130.0";"nM";"6.89";"";"";"UO_0000065";"13.33";"0.25";"3.37";"5.04";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL218353";"";"0";"405.54";"0";"2.89";"Table 2, r13c3";"O=C(NCCCCCC(=O)N1CCC[C@H]1C(=O)O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL216219";"";"0";"445.56";"0";"2.35";"Table 2, r8c3";"O=C(CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1cnc[nH]1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3327078";"";"0";"387.40";"0";"3.74";"21";"CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"T1/2";"'='";"0.3817";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL470823";"";"0";"489.85";"0";"4.98";"6-23";"Cc1cc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C)cc1Cl";"IC50";"'='";"52.1";"nM";"7.28";"";"";"UO_0000065";"14.87";"0.33";"2.30";"10.96";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL504294";"";"0";"365.28";"0";"2.28";"6-12";"CS(=O)(=O)N1CCC(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL516182";"";"0";"473.62";"0";"4.27";"8-15";"COc1ccc2nc(NC(=O)C3CCN(S(=O)(=O)c4c(C)cc(C)cc4C)CC3)sc2c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469989";"";"0";"406.59";"0";"3.71";"8-41";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCCC3C)CC2)c(C)c1";"IC50";"'='";"37.2";"nM";"7.43";"";"";"UO_0000065";"18.27";"0.36";"3.72";"11.18";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469361";"";"0";"469.43";"0";"4.64";"8-30";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3cc(Cl)ccc3Cl)CC2)c(C)c1";"Inhibition";"'='";"98.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469572";"";"0";"449.02";"0";"4.54";"8-34";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC(C)c3ccc(Cl)cc3)CC2)c(C)c1";"Inhibition";"'='";"94.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512659";"";"0";"452.98";"0";"4.12";"8-36";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(F)cc3Cl)CC2)c(C)c1";"Inhibition";"'='";"98.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469998";"";"0";"452.98";"0";"4.12";"8-37";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3c(F)cccc3Cl)CC2)c(C)c1";"Inhibition";"'='";"97.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469784";"";"0";"434.99";"0";"3.98";"8-39";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3)CC2)c(C)c1";"Inhibition";"'='";"97.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469989";"";"0";"406.59";"0";"3.71";"8-41";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCCC3C)CC2)c(C)c1";"Inhibition";"'='";"77.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469580";"";"0";"440.61";"0";"4.21";"8-45";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCc4ccccc43)CC2)c(C)c1";"Inhibition";"'='";"79.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512842";"";"0";"406.59";"0";"3.71";"8-46";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCC(C)CC3)CC2)c(C)c1";"Inhibition";"'='";"86.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1271607";"";"0";"423.40";"0";"4.28";"11";"O=C(NCc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cc1)c1ccncc1";"IC50";"'='";"650.0";"nM";"6.19";"";"";"UO_0000065";"14.61";"0.27";"1.91";"8.51";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL11522";"";"0";"234.30";"0";"2.85";"172";"O=C(Nc1ccc(O)cc1)NC1CCCCC1";"IC50";"'='";"1.05";"";"";"Non standard unit for type";"";"";"";"";"";"";"False";"CHEMBL809079";"Inhibitory activity against human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1136721";"1";"Scientific Literature";"J. Med. Chem.";"2003";"None"
"CHEMBL560030";"";"0";"340.51";"0";"4.63";"14";"CCNC(=O)NCCCC/C=C\CCCCCCCCCC(=O)O";"IC50";"'='";"2596.0";"nM";"5.59";"";"";"UO_0000065";"16.40";"0.32";"0.96";"7.12";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL560420";"";"0";"339.52";"1";"5.22";"18";"CCCCCCC(=O)NCCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"79.0";"nM";"7.10";"";"";"UO_0000065";"20.92";"0.40";"1.88";"10.70";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL561706";"";"0";"339.52";"1";"5.22";"22";"CCCCCCNC(=O)CCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"66.0";"nM";"7.18";"";"";"UO_0000065";"21.15";"0.41";"1.96";"10.81";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL1271551";"";"0";"409.37";"0";"4.60";"10";"O=C(Nc1ccncc1)c1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cc1";"IC50";"'='";"450.0";"nM";"6.35";"";"";"UO_0000065";"15.50";"0.29";"1.75";"8.73";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL201094";"FUBERIDAZOLE";"0";"184.20";"0";"2.82";"q";"c1coc(-c2nc3ccccc3[nH]2)c1";"IC50";"'='";"207000.0";"nM";"";"Outside typical range";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL551058";"";"0";"466.56";"0";"3.59";"2b";"CS(=O)(=O)c1ccc(-c2noc(C3CCN(C(=O)NC4CC4c4ccccc4)CC3)n2)cc1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"18.00";"0.35";"4.81";"7.97";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL564757";"";"0";"389.46";"0";"3.58";"2e";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3cccnc3)no2)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"20.94";"0.38";"4.57";"9.69";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL511123";"";"0";"486.38";"0";"3.93";"6-21";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c([N+](=O)[O-])c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469338";"";"0";"495.35";"0";"4.73";"6-16";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccccc2C(F)(F)F)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472630";"";"0";"392.57";"0";"3.46";"8-14";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCCC3)CC2)c(C)c1";"IC50";"'='";"16.4";"nM";"7.79";"";"";"UO_0000065";"19.83";"0.39";"4.33";"11.71";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470000";"";"0";"465.96";"0";"4.21";"8-23";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3ccc(Cl)cc3[N+](=O)[O-])CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471858";"";"0";"506.25";"1";"4.47";"6-7";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccccc2Br)CC1";"Inhibition";"'='";"63.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1271497";"";"0";"409.37";"0";"4.60";"2";"O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cc1)c1cccnc1";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"18.66";"0.35";"3.04";"10.51";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL219043";"";"0";"559.71";"2";"1.74";"Table 3, r3c1";"N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"2100.0";"nM";"5.68";"";"";"UO_0000065";"10.14";"0.19";"3.94";"2.86";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL222080";"";"0";"298.43";"0";"4.02";"4{1}";"C[C@@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)c1ccccc1";"Inhibition";"'='";"10.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL448400";"OBTUSIFOLIN";"0";"284.27";"0";"2.19";"5";"COc1c(O)c(C)cc2c1C(=O)c1c(O)cccc1C2=O";"Inhibition";"'='";"2.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3634701";"";"0";"596.54";"3";"-2.03";"14";"COc1cc(O[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)c2c(O)c3c(=O)oc(C)cc3cc2c1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL193019";"";"0";"245.37";"0";"3.32";"a-2";"O=C(CC1CCCCC1)NCCc1ccccc1";"IC50";"'='";"4000.0";"nM";"5.40";"";"";"UO_0000065";"22.00";"0.41";"2.08";"18.55";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL3763491";"";"0";"311.38";"0";"3.27";"2c";"CCC(Cc1ccc(C(=O)NCc2ccccc2)cc1)C(=O)O";"Inhibition";"'='";"4.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3767858";"Inhibition of human recombinant sEH using PHOME as substrate at 10 uM preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL552402";"";"0";"361.45";"0";"4.27";"1j";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc3ccccc3o2)CC1";"IC50";"'='";"7.5";"nM";"8.12";"";"";"UO_0000065";"22.48";"0.41";"3.85";"13.92";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL557032";"";"0";"390.45";"0";"2.97";"2g";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3cnccn3)no2)CC1";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"20.38";"0.37";"4.99";"8.20";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL589621";"";"0";"413.73";"1";"5.40";"37";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccc(Cl)cc2)CC1";"EC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"19.34";"0.42";"2.60";"19.24";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL3127869";"";"0";"413.54";"0";"3.37";"51";"N#CC1(COc2nc(C3CC3)c(C(=O)N[C@H]3C4CC5CC3C[C@](O)(C5)C4)s2)CC1";"IC50";"'='";"12000.0";"nM";"4.92";"";"";"UO_0000065";"11.90";"0.23";"1.55";"5.17";"False";"CHEMBL3130369";"Inhibition of sEH (unknown origin)";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3124933";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL224740";"";"0";"448.69";"1";"6.50";"11";"CC(C)(C)OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"19.80";"0.38";"2.39";"13.18";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224912";"";"0";"448.69";"1";"6.50";"9";"CCC(C)OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"20.40";"0.39";"2.65";"13.58";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL501669";"";"0";"260.34";"0";"4.36";"6c";"c1ccc(CNc2ccc(-c3ccccc3)cn2)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL565734";"";"0";"240.33";"0";"3.91";"7e";"c1ccc(CNc2nc3ccccc3s2)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL578770";"";"0";"279.22";"0";"3.99";"7i";"FC(F)(F)c1ccc(Nc2noc3cnccc23)cc1";"IC50";"'='";"31.0";"nM";"7.51";"";"";"UO_0000065";"26.89";"0.51";"3.52";"14.74";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL578380";"";"0";"278.23";"0";"4.59";"7l";"FC(F)(F)c1ccccc1Nc1noc2ccccc12";"IC50";"'='";"960.0";"nM";"6.02";"";"";"UO_0000065";"21.63";"0.41";"1.43";"15.81";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL577695";"";"0";"346.23";"1";"5.61";"7t";"FC(F)(F)c1ccc(Nc2noc3c(C(F)(F)F)cccc23)cc1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"24.26";"0.48";"2.79";"22.07";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL578047";"";"0";"346.23";"1";"5.61";"7u";"FC(F)(F)c1ccc(Nc2noc3cc(C(F)(F)F)ccc23)cc1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"22.37";"0.44";"2.13";"20.35";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL583880";"";"0";"422.33";"1";"7.28";"7w";"FC(F)(F)c1ccc(Nc2noc3cc(-c4ccccc4C(F)(F)F)ccc23)cc1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"19.17";"0.37";"0.82";"21.27";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL576459";"";"0";"372.32";"1";"6.40";"7y";"Fc1ccccc1-c1ccc2c(Nc3ccc(C(F)(F)F)cc3)noc2c1";"IC50";"'='";"91.0";"nM";"7.04";"";"";"UO_0000065";"18.91";"0.36";"0.64";"18.50";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL456632";"";"0";"412.57";"0";"4.33";"6b";"O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"2.5";"nM";"8.60";"";"";"UO_0000065";"20.85";"0.39";"4.27";"16.93";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL456633";"";"0";"346.47";"0";"3.31";"6c";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)C1CCCCC1";"IC50";"'='";"390.0";"nM";"6.41";"";"";"UO_0000065";"18.50";"0.35";"3.10";"12.62";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL568544";"";"0";"436.84";"0";"3.40";"34";"CS(=O)(=O)c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1";"IC50";"'='";"28.0";"nM";"7.55";"";"";"UO_0000065";"17.29";"0.37";"4.15";"8.85";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL566047";"";"0";"402.39";"0";"2.75";"37";"CS(=O)(=O)c1ccccc1CNC(=O)c1ccc(OCCC(F)(F)F)nc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL1672130";"";"0";"307.35";"0";"3.81";"8";"Cc1nc2cc(NC(=O)N[C@H]3C[C@@H]3c3ccccc3)ccc2o1";"IC50";"'='";"39.81";"nM";"7.40";"";"";"UO_0000065";"24.08";"0.44";"3.59";"11.02";"False";"CHEMBL1680920";"Inhibition of human soluble epoxide hydrolase in cell free system";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL2424986";"";"0";"473.00";"0";"4.65";"9j";"Cc1cc(C2CCN(C(=O)Nc3ccc(Cl)cc3)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL1086820";"";"0";"436.43";"0";"3.41";"5r,para isomer";"O=C(Nc1ccc(C(=O)NCCN2CCOCC2)cc1)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"20.62";"0.40";"5.59";"10.88";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087864";"";"0";"343.36";"0";"2.94";"5w,para isomer";"O=C(Nc1ccc(F)cc1)Nc1ccc(C(=O)N2CCOCC2)cc1";"IC50";"'='";"170.0";"nM";"6.77";"";"";"UO_0000065";"19.72";"0.37";"3.83";"9.58";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088083";"";"0";"429.42";"0";"3.37";"9c, para isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(S(=O)(=O)N2CCOCC2)cc1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"20.96";"0.42";"5.63";"10.26";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088227";"";"0";"471.50";"0";"3.85";"13b, para isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(S(=O)(=O)CCCN2CCOCC2)cc1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.09";"0.38";"5.15";"10.26";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2424981";"";"0";"444.60";"0";"3.81";"9e";"Cc1cc(C2CCN(C(=O)NC3CCCCC3)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"IC50";"'='";"3471.0";"nM";"5.46";"";"";"UO_0000065";"12.28";"0.24";"1.65";"6.48";"False";"CHEMBL2427204";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL560419";"";"0";"342.48";"0";"4.17";"15";"CCCCCNC(=O)NOCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"1374.0";"nM";"5.86";"";"";"UO_0000065";"17.12";"0.33";"1.69";"6.69";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL469339";"";"0";"470.19";"0";"4.92";"6-30";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(C(=O)c2ccc(Br)cc2)CC1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472078";"";"0";"436.30";"0";"4.07";"6-36";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1";"Inhibition";"'='";"44.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471240";"";"0";"471.37";"1";"5.37";"6-37";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(P(c2ccccc2)c2ccccc2)CC1";"Inhibition";"'='";"3.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471451";"";"0";"464.63";"1";"5.04";"8-4";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)N[C@H](C)c3cccc4ccccc34)CC2)c(C)c1";"Inhibition";"'='";"-4.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472630";"";"0";"392.57";"0";"3.46";"8-14";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCCC3)CC2)c(C)c1";"Inhibition";"'='";"87.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469999";"";"0";"414.57";"0";"3.37";"8-21";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCCc3ccccc3)CC2)c(C)c1";"Inhibition";"'='";"67.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3327069";"";"0";"397.32";"0";"3.77";"9";"O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)CC(F)(F)F)CC1";"T1/2";"'='";"0.405";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3325465";"";"0";"337.51";"0";"3.29";"17";"CCC(C)C(=O)N1CCC(NC(=O)N[C@H]2CC[C@H](CC)CC2)CC1";"Ki";"'='";"0.23";"nM";"9.64";"";"";"UO_0000065";"28.56";"0.55";"6.35";"15.69";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327067";"";"0";"371.40";"0";"3.86";"7";"CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"0.22";"nM";"9.66";"";"";"UO_0000065";"26.00";"0.51";"5.80";"15.72";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL242655";"";"0";"396.57";"0";"3.49";"AEPU";"CCOCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"19.80";"0.38";"4.36";"11.41";"True";"CHEMBL894939";"Inhibition of human sEH by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL395987";"";"0";"388.60";"1";"5.16";"9i";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCC2CCCCC2)CC1";"IC50";"'='";"2.5";"nM";"8.60";"";"";"UO_0000065";"22.14";"0.42";"3.44";"17.08";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL242256";"";"0";"306.45";"0";"3.21";"3h";"CO[C@H]1CC[C@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"2.6";"nM";"8.59";"";"";"UO_0000065";"28.01";"0.53";"5.38";"17.05";"True";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL397693";"";"0";"476.61";"1";"5.85";"3g";"CC(C)Oc1cc(F)c(CO[C@H]2CC[C@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c(F)c1";"IC50";"'='";"3.5";"nM";"8.46";"";"";"UO_0000065";"17.74";"0.34";"2.61";"14.19";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL3322802";"";"0";"479.69";"1";"5.05";"BDBM50057445";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)NS(=O)(=O)c1ccccc1";"IC50";"'='";"41.0";"nM";"7.39";"";"326381";"UO_0000065";"15.40";"0.31";"2.34";"7.08";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4109660";"";"0";"450.32";"None";"None";"BDBM179759";"";"IC50";"'>'";"500.0";"nM";"";"";"326392";"UO_0000065";"";"";"";"";"False";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3919331";"";"0";"433.96";"0";"3.13";"BDBM181777";"O=C(NCCCc1ccccc1)N1CC2(CCN2S(=O)(=O)c2ccc(Cl)cc2)C1";"IC50";"'='";"1993.0";"nM";"5.70";"";"328784";"UO_0000065";"13.14";"0.27";"2.57";"8.18";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"21.71";"0.42";"3.28";"10.87";"True";"CHEMBL894939";"Inhibition of human sEH by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL497828";"";"0";"453.48";"0";"4.11";"2b";"CS(=O)(=O)c1ccc2c(c1)CCC1(CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC1)O2";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"19.18";"0.38";"4.59";"13.66";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL495793";"";"0";"471.56";"0";"4.23";"rac-1d";"Cn1nccc1Nc1ccc2c(c1)C(=O)CC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"18.07";"0.33";"4.29";"9.63";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1668938";"";"0";"330.43";"0";"2.32";"14q";"O=C(NC1CCCCC1)NC1CCN(C(=O)c2ccccn2)CC1";"IC50";"'='";"67.0";"nM";"7.17";"";"";"UO_0000065";"21.71";"0.41";"4.85";"9.65";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL2397144";"";"0";"456.85";"1";"5.57";"7, t-CUCB";"O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N[C@H]1CC[C@H](Oc2cccc(C(=O)O)c2)CC1";"IC50";"'='";"8.6";"nM";"8.07";"";"";"UO_0000065";"17.65";"0.36";"2.50";"9.20";"False";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL396759";"";"0";"443.65";"0";"3.16";"21";"CS(=O)(=O)NCCCCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"17.94";"0.36";"4.80";"8.24";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL522211";"";"0";"363.46";"0";"3.51";"ent-1l";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CCc3ncccc3O2)CC1";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL519149";"";"0";"404.51";"0";"4.14";"rac-2g";"O=C1CC2(CCN(C(=O)NC3CCc4ccccc4CC3)CC2)Oc2ccccc21";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"20.02";"0.37";"3.96";"13.81";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL523565";"";"0";"379.46";"0";"3.00";"ent-1k";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CC1)CC(O)c1ncccc1O2";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"21.34";"0.39";"5.10";"10.84";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL482845";"";"0";"376.46";"0";"3.88";"rac-2f";"O=C1CC2(CCN(C(=O)NC3CCc4ccccc43)CC2)Oc2ccccc21";"IC50";"'='";"20.0";"nM";"7.70";"";"";"UO_0000065";"20.45";"0.38";"3.82";"13.13";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL495993";"";"0";"377.44";"0";"3.15";"ent-1j";"O=C1CC2(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)Oc2cccnc21";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"22.25";"0.41";"5.25";"11.74";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1257879";"";"0";"367.45";"0";"4.00";"16";"CCC(=O)N1CCC(NC(=O)Nc2ccc(Oc3ccccc3)cc2)CC1";"IC50";"'='";"3.5";"nM";"8.46";"";"";"UO_0000065";"23.01";"0.43";"4.46";"11.97";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1087977";"";"0";"428.37";"1";"5.28";"5e,para isomer";"O=C(Nc1ccc(C(=O)c2ccc(C(=O)O)cc2)cc1)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"20.0";"nM";"7.70";"";"";"UO_0000065";"17.97";"0.34";"2.42";"8.06";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2180629";"";"0";"355.44";"0";"3.37";"6b";"O=C(NCc1cccc(Cn2cccc2C(=O)O)c1)NC1CCCCC1";"IC50";"'='";"1923.0";"nM";"5.72";"";"";"UO_0000065";"16.08";"0.30";"2.35";"6.86";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL595";"PIOGLITAZONE";"4";"356.45";"0";"3.16";"pioglitazone";"CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL550898";"";"0";"337.50";"0";"4.67";"21";"CCCCCCC(=O)NCCCCCCCC#CCCCC(=O)O";"IC50";"'='";"272.0";"nM";"6.57";"";"";"UO_0000065";"19.45";"0.37";"1.90";"9.89";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL1258221";"";"0";"293.34";"0";"2.35";"24";"CCC(=O)N1CCC(NC(=O)Nc2ccc(F)cc2)CC1";"IC50";"'='";"79.0";"nM";"7.10";"";"";"UO_0000065";"24.21";"0.46";"4.75";"11.56";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1271498";"";"0";"409.37";"0";"4.60";"3";"O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cc1)c1ccncc1";"IC50";"'='";"7.3";"nM";"8.14";"";"";"UO_0000065";"19.88";"0.37";"3.54";"11.19";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2158537";"";"0";"331.37";"0";"4.75";"2";"O=C(Nc1cccc(O)c1)OCC1c2ccccc2-c2ccccc21";"IC50";"'='";"5500.0";"nM";"5.26";"";"";"UO_0000065";"15.87";"0.29";"0.51";"8.98";"False";"CHEMBL2162306";"Inhibition of sEH using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to substrate addition measured every min for 15 mins by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2157944";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL568744";"";"0";"261.33";"0";"3.76";"6e";"c1ccc(CNc2cnc(-c3ccccc3)cn2)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL565942";"";"0";"355.32";"1";"5.65";"7aa";"FC(F)(F)c1ccc(Nc2noc3cc(-c4ccncc4)ccc23)cc1";"IC50";"'='";"58.0";"nM";"7.24";"";"";"UO_0000065";"20.37";"0.38";"1.59";"14.20";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1077963";"";"0";"387.87";"0";"4.17";"3f";"O=C(O)CCC1(c2ccccn2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL2180622";"";"0";"435.57";"0";"4.48";"5d";"CCOC(=O)c1cccn1Cc1ccccc1CNC(=O)NC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3";"IC50";"'='";"43.0";"nM";"7.37";"";"";"UO_0000065";"16.91";"0.31";"2.89";"10.18";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL1668936";"";"0";"365.38";"0";"2.25";"14o";"CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"IC50";"'='";"3.7";"nM";"8.43";"";"";"UO_0000065";"23.08";"0.48";"6.18";"10.74";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL2180636";"";"0";"433.39";"0";"4.45";"6i";"O=C(NCc1ccc(Cn2cccc2C(=O)O)cc1)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"258.0";"nM";"6.59";"";"";"UO_0000065";"15.20";"0.29";"2.14";"7.12";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL3633679";"";"0";"393.53";"1";"5.20";"4a";"Cc1ccc(-c2cc(CNC(=O)NC34CC5CC(C)(CC(C)(C5)C3)C4)no2)cc1";"IC50";"'='";"25.8";"nM";"7.59";"";"";"UO_0000065";"19.28";"0.36";"2.39";"11.30";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL465439";"";"0";"520.49";"2";"-0.02";"12";"COc1cc2c(c(OC)c1OC)C(=O)c1c(cc(C)c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c1OC)C2=O";"Inhibition";"'='";"28.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL461085";"CHRYSOOBTUSIN";"0";"358.35";"0";"2.51";"3";"COc1cc2c(c(OC)c1OC)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3634700";"";"0";"556.52";"3";"-1.94";"13";"COc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(OC)c(C(C)=O)c(O[C@H]3OC[C@@](O)(CO)[C@@H]3O)cc2c1";"Ki";"'='";"600.0";"nM";"6.22";"";"";"UO_0000065";"11.18";"0.22";"8.16";"2.91";"False";"CHEMBL3635710";"Reversible-uncompetitive inhibition of sEH (unknown origin) by Lineweaver-Burk plot";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL589620";"";"0";"404.30";"0";"4.62";"40";"N#Cc1cccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c1";"IC50";"'='";"4.9";"nM";"8.31";"";"";"UO_0000065";"20.55";"0.42";"3.69";"12.71";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL592743";"";"0";"436.34";"0";"4.11";"45";"CNC(=O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"IC50";"'='";"4.2";"nM";"8.38";"";"";"UO_0000065";"19.20";"0.39";"4.27";"11.85";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL456427";"";"0";"398.55";"0";"3.94";"6a";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"88.0";"nM";"7.06";"";"";"UO_0000065";"17.70";"0.33";"3.12";"13.89";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL461894";"";"0";"408.42";"0";"4.06";"6e";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)c1ccc(C(F)(F)F)cc1";"IC50";"'='";"93.0";"nM";"7.03";"";"";"UO_0000065";"17.22";"0.33";"2.97";"13.84";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1933648";"";"0";"427.50";"0";"2.97";"14-31";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2[N+](=O)[O-])CC1";"IC50";"'='";"7.7";"nM";"8.11";"";"";"UO_0000065";"18.98";"0.38";"5.14";"7.40";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933671";"";"0";"373.45";"0";"3.29";"15-3";"O=C(NC1CCCCCC1)C1CCN(C(=O)c2ccc([N+](=O)[O-])cc2)CC1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"15.85";"0.30";"2.63";"6.40";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933649";"";"0";"522.30";"1";"4.45";"14-32";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(Br)cc2Br)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"15.17";"0.40";"3.47";"11.91";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933651";"";"0";"392.57";"0";"3.54";"14-34";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c(C)c1";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"22.41";"0.44";"5.26";"13.23";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933657";"";"0";"424.56";"0";"2.94";"14-40";"COc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1OC";"IC50";"'='";"360.0";"nM";"6.44";"";"";"UO_0000065";"15.18";"0.30";"3.50";"7.59";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL483876";"";"0";"380.46";"0";"4.25";"rac-1g";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CCc3cc(F)ccc3O2)CC1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"22.40";"0.42";"4.27";"20.50";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL447085";"";"0";"353.44";"0";"4.14";"2d";"O=C(CCc1ccccc1)N1CCC2(CCc3cc(F)ccc3O2)CC1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"24.11";"0.45";"4.38";"28.85";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL495601";"";"0";"390.48";"0";"3.75";"rac-2e";"O=C1CC2(CCN(C(=O)NC3CCc4ccccc4C3)CC2)Oc2ccccc21";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"21.26";"0.39";"4.55";"14.16";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL447085";"";"0";"353.44";"0";"4.14";"2d";"O=C(CCc1ccccc1)N1CCC2(CCc3cc(F)ccc3O2)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"23.07";"0.43";"4.01";"27.61";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL523565";"";"0";"379.46";"0";"3.00";"ent-1k";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CC1)CC(O)c1ncccc1O2";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"21.34";"0.39";"5.10";"10.84";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL568915";"";"0";"361.49";"0";"3.24";"19b";"O=C(Nc1ccc(OCCCN2CCOCC2)cc1)NC1CCCCC1";"IC50";"'='";"5.4";"nM";"8.27";"";"";"UO_0000065";"22.87";"0.43";"5.03";"13.16";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL557037";"";"0";"354.45";"0";"2.97";"20d";"O=C(Cc1ccccc1)Nc1ccc(OCCCN2CCOCC2)cc1";"IC50";"'='";"870.0";"nM";"6.06";"";"";"UO_0000065";"17.10";"0.32";"3.09";"11.93";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL568773";"";"0";"331.42";"0";"3.62";"9";"Nc1ccc(C(=O)NCCC(c2ccccc2)c2ccccc2)cn1";"IC50";"'='";"9.1";"nM";"8.04";"";"";"UO_0000065";"24.26";"0.44";"4.42";"11.82";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470000";"";"0";"465.96";"0";"4.21";"8-23";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3ccc(Cl)cc3[N+](=O)[O-])CC2)c(C)c1";"Inhibition";"'='";"-25.0";"%";"";"Outside typical range";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL513874";"";"0";"368.50";"0";"1.78";"8-25";"COCCNC(=O)C1CCN(S(=O)(=O)c2c(C)cc(C)cc2C)CC1";"Inhibition";"'='";"-6.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1079256";"";"0";"386.88";"0";"4.77";"entA-2b";"O=C(O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"4000.0";"nM";"5.40";"";"";"UO_0000065";"13.95";"0.27";"0.63";"7.75";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1079244";"";"0";"412.93";"0";"3.61";"2k";"O=C(Nc1ccc(Cl)cc1)N1CCCC(CCC2=NNNN2)(c2ccccc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1079360";"";"0";"328.84";"0";"4.93";"1a";"CC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1257755";"";"0";"289.38";"0";"2.52";"BDBM50327819";"CCC(=O)N1CCC(NC(=O)Nc2cccc(C)c2)CC1";"IC50";"'='";"40.0";"nM";"7.40";"";"377014";"UO_0000065";"25.56";"0.48";"4.88";"12.04";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1258904";"";"0";"359.35";"0";"3.11";"BDBM50327809";"CCC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"3.7";"nM";"8.43";"";"377043";"UO_0000065";"23.46";"0.46";"5.32";"11.93";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257286";"";"0";"519.57";"1";"3.52";"BDBM50327825";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CN2CCN(Cc3ccccc3)CC2)CC1";"IC50";"'='";"1.5";"nM";"8.82";"";"377047";"UO_0000065";"16.98";"0.33";"5.30";"11.44";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1668924";"";"0";"373.42";"0";"2.54";"14c";"CC(=O)N1CCC(NC(=O)NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)CC1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"18.53";"0.36";"4.38";"11.26";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL3633666";"";"0";"379.50";"0";"4.67";"3a";"Cc1ccc(-c2cc(CNC(=O)NCC34CC5CC(CC(C5)C3)C4)no2)cc1";"IC50";"'='";"15.4";"nM";"7.81";"";"";"UO_0000065";"20.59";"0.38";"3.14";"11.63";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL242459";"";"0";"412.53";"0";"4.34";"11, t-AUCB";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"Inhibition";"'='";"47.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2400593";"Inhibition of human recombinant soluble epoxide hydrolase using ((3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate at 1 nM preincubated for 5 mins prior to substrate addition measured after 60 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL4068980";"";"0";"213.28";"0";"3.01";"6";"CC(C)=C/C=C1\C(=O)N(C)c2ccccc21";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL3327063";"";"0";"357.38";"0";"3.62";"3";"CCCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"2.23";"nM";"8.65";"";"";"UO_0000065";"24.21";"0.47";"5.03";"14.08";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3558236";"";"0";"376.48";"0";"4.33";"BDBM179756";"CCCCCNC(=O)NCCCC/C=C\CCCCCCP(=O)(O)O";"IC50";"'>'";"500.0";"nM";"";"";"326383";"UO_0000065";"";"";"";"";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL195763";"";"0";"349.52";"0";"4.37";"13";"CCCCCOC(=O)CCCCC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2400.0";"nM";"5.62";"";"";"UO_0000065";"16.08";"0.31";"1.25";"10.14";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL556717";"";"0";"436.51";"0";"4.05";"(S)-24";"CS(=O)(=O)c1ccc([C@@H](CCNC(=O)c2ccc(C#N)cc2)c2ccc(F)cc2)cc1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"18.55";"0.36";"4.05";"9.30";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL2425011";"";"0";"404.54";"0";"2.88";"9c";"Cc1cc(C2CCN(C(=O)NC(C)C)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"Inhibition";"'='";"45.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL245141";"";"0";"280.41";"0";"2.42";"7";"O=C(NCCCCCO)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"84.0";"nM";"7.08";"";"";"UO_0000065";"25.23";"0.48";"4.66";"11.53";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL3233605";"";"0";"198.23";"0";"1.96";"4";"Cn1cc(-c2nc3ccccc3[nH]2)cn1";"IC50";"'='";"127000.0";"nM";"3.90";"";"";"UO_0000065";"19.65";"0.35";"1.94";"8.38";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL1458";"1,3-DICYCLOHEXYLUREA";"0";"224.35";"0";"2.95";"DCU";"O=C(NC1CCCCC1)NC1CCCCC1";"IC50";"'='";"25.3";"nM";"7.60";"";"";"UO_0000065";"33.86";"0.65";"4.65";"18.47";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL4071682";"";"0";"344.32";"0";"2.25";"1";"COc1ccc(/C=C/C(=O)OCC(=O)c2ccc(O)c(O)c2)cc1O";"Inhibition";"'='";"98.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4010815";"Inhibition of sEH (unknown origin) at 100 uM using PHOME as substrate after 40 mins by fluorescence photometric method relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL3104620";"";"0";"481.90";"0";"4.90";"23";"O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3cccc(Cl)c3)CC2)C1";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"18.51";"0.37";"4.02";"14.42";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104618";"";"0";"447.46";"0";"4.24";"21";"O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccccc3)CC2)C1";"IC50";"'='";"3.2";"nM";"8.49";"";"";"UO_0000065";"18.98";"0.36";"4.25";"13.73";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL191663";"";"0";"217.31";"0";"3.60";"d-2";"O=C(CC1CCCCC1)Nc1ccccc1";"IC50";"'='";"16000.0";"nM";"4.80";"";"";"UO_0000065";"22.07";"0.41";"1.20";"16.48";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL589138";"";"0";"472.39";"0";"3.65";"46";"CNS(=O)(=O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"EC50";"'='";"0.29";"nM";"9.54";"";"";"UO_0000065";"20.19";"0.43";"5.89";"10.87";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL564360";"";"0";"389.88";"0";"4.09";"12l";"O=C(Nc1ccc(Cl)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"22.31";"0.44";"4.61";"13.85";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL560720";"";"0";"356.43";"0";"2.83";"12p";"O=C(Nc1cccnc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"5000.0";"nM";"5.30";"";"";"UO_0000065";"14.87";"0.28";"2.47";"7.00";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL550794";"";"0";"390.43";"0";"3.25";"14f";"O=C(Cc1ccc(F)c(F)c1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"321.0";"nM";"6.49";"";"";"UO_0000065";"16.63";"0.32";"3.24";"12.78";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL550652";"";"0";"325.42";"0";"2.26";"1c";"Cn1cnnc1C1CCN(C(=O)NC2CC2c2ccccc2)CC1";"IC50";"'>'";"20000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL552196";"";"0";"341.41";"0";"3.13";"1f";"Cc1c(O)noc1C1CCN(C(=O)NC2CC2c2ccccc2)CC1";"IC50";"'='";"1100.0";"nM";"5.96";"";"";"UO_0000065";"17.45";"0.33";"2.83";"7.58";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL552196";"";"0";"341.41";"0";"3.13";"1f";"Cc1c(O)noc1C1CCN(C(=O)NC2CC2c2ccccc2)CC1";"IC50";"'>'";"20000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL551058";"";"0";"466.56";"0";"3.59";"2b";"CS(=O)(=O)c1ccc(-c2noc(C3CCN(C(=O)NC4CC4c4ccccc4)CC3)n2)cc1";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"17.06";"0.33";"4.37";"7.55";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL4072936";"";"0";"324.42";"0";"3.27";"38";"CNC(=O)c1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)cc1";"IC50";"'='";"1900.0";"nM";"5.72";"";"";"UO_0000065";"17.64";"0.33";"2.45";"9.83";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4063293";"";"0";"335.41";"0";"3.09";"43";"CC(C)(C)c1ccc(C(=O)NCc2ccc(-c3nnn[nH]3)cc2)cc1";"IC50";"'='";"18200.0";"nM";"4.74";"";"";"UO_0000065";"14.13";"0.26";"1.65";"5.67";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4084686";"";"0";"329.47";"0";"3.65";"52";"C[S+]([O-])c1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)cc1";"IC50";"'='";"220.0";"nM";"6.66";"";"";"UO_0000065";"20.21";"0.40";"3.01";"14.42";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL1258447";"";"0";"293.34";"0";"2.35";"BDBM50327826";"CCC(=O)N1CCC(NC(=O)Nc2cccc(F)c2)CC1";"IC50";"'='";"39.0";"nM";"7.41";"";"377031";"UO_0000065";"25.26";"0.48";"5.06";"12.06";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1258668";"";"0";"344.24";"0";"3.52";"BDBM50327841";"CCC(=O)N1CCC(NC(=O)Nc2c(Cl)cccc2Cl)CC1";"IC50";"'>'";"50000.0";"nM";"";"";"377037";"UO_0000065";"";"";"";"";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257170";"";"0";"442.83";"0";"4.06";"BDBM50327854";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2ccc(Cl)nc2)CC1";"IC50";"'='";"0.6";"nM";"9.22";"";"377045";"UO_0000065";"20.82";"0.42";"5.16";"11.04";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1258557";"";"0";"344.24";"0";"3.52";"BDBM50327853";"CCC(=O)N1CCC(NC(=O)Nc2ccc(Cl)c(Cl)c2)CC1";"IC50";"'='";"3.4";"nM";"8.47";"";"377035";"UO_0000065";"24.60";"0.53";"4.95";"13.78";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL32969";"";"0";"208.21";"0";"1.59";"7";"COC(=O)/C=C/c1ccc(O)c(OC)c1";"Inhibition";"'='";"99.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4010815";"Inhibition of sEH (unknown origin) at 100 uM using PHOME as substrate after 40 mins by fluorescence photometric method relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL2313179";"";"0";"474.93";"1";"5.02";"7-41";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)c(C)c1";"IC50";"'='";"78.0";"nM";"7.11";"";"";"UO_0000065";"14.97";"0.31";"2.09";"10.69";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313169";"";"0";"386.52";"0";"3.65";"7-31";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3C)CC2)c(C)c1";"IC50";"'='";"20.0";"nM";"7.70";"";"";"UO_0000065";"19.92";"0.39";"4.05";"11.58";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313167";"";"0";"372.49";"0";"3.34";"7-29";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c(C)c1";"IC50";"'='";"6.9";"nM";"8.16";"";"";"UO_0000065";"21.91";"0.43";"4.82";"12.28";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313204";"";"0";"352.50";"0";"2.48";"7-1";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NCC(C)C)CC2)c(C)c1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"21.97";"0.44";"5.26";"11.65";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313185";"";"0";"412.56";"0";"3.38";"7-2";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)c(C)c1";"IC50";"'='";"6900.0";"nM";"5.16";"";"";"UO_0000065";"12.51";"0.24";"1.78";"7.76";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1081703";"";"0";"385.51";"1";"5.01";"1h";"CC1(c2ccccc2)CCCN(C(=O)NCc2ccc(-c3ccccn3)cc2)C1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"23.35";"0.42";"3.99";"19.90";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL302116";"";"0";"408.54";"0";"3.31";"32";"CCOC(=O)CCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC90";"'='";"1500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677486";"Tested for 90 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL11326";"";"0";"232.33";"0";"3.17";"189";"CN(C(=O)NC1CCCCC1)c1ccccc1";"IC50";"'='";"2.11";"";"";"Non standard unit for type";"";"";"";"";"";"";"False";"CHEMBL809079";"Inhibitory activity against human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1136721";"1";"Scientific Literature";"J. Med. Chem.";"2003";"None"
"CHEMBL3322799";"";"0";"438.65";"1";"5.46";"BDBM50057422";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCC(=O)NCC(=O)O)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"423459";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4127661";"";"0";"286.44";"0";"3.80";"2a";"S=C(Nc1ccccc1)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"229.0";"nM";"6.64";"";"";"UO_0000065";"23.18";"0.45";"2.84";"27.60";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1668937";"";"0";"408.38";"0";"3.41";"14p";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2cccnc2)CC1";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"21.54";"0.41";"5.39";"10.53";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668936";"";"0";"365.38";"0";"2.25";"14o";"CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"IC50";"'='";"26.0";"nM";"7.58";"";"";"UO_0000065";"20.76";"0.43";"5.34";"9.66";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL1668927";"";"0";"267.37";"0";"1.63";"14f";"CC(=O)N1CCC(NC(=O)NC2CCCCC2)CC1";"IC50";"'='";"29.0";"nM";"7.54";"";"";"UO_0000065";"28.19";"0.54";"5.91";"12.27";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668926";"";"0";"279.38";"0";"1.49";"14e";"CC(=O)N1CCC(NC(=O)NC2C3CCC2CC3)CC1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"24.77";"0.47";"5.43";"11.26";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL243521";"";"0";"356.44";"0";"3.48";"56";"O=C(NCC#CCOc1ccc(F)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"128.0";"nM";"6.89";"";"";"UO_0000065";"19.34";"0.36";"3.41";"13.69";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL223281";"";"0";"448.69";"1";"6.50";"71";"CCCCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"20.27";"0.39";"2.60";"13.49";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031791";"";"0";"354.37";"0";"4.68";"1";"O=C(Nc1cccc(OC(F)(F)F)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.1";"nM";"8.51";"";"";"UO_0000065";"24.01";"0.46";"3.83";"16.90";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL265024";"";"0";"366.46";"0";"2.14";"29";"CCOC(=O)COC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"390.0";"nM";"6.41";"";"";"UO_0000065";"17.49";"0.34";"4.27";"6.84";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL1257759";"";"0";"457.47";"0";"3.87";"58";"Cc1ccc(S(=O)(=O)N2CCC(NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"20.54";"0.41";"5.53";"10.71";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257518";"";"0";"455.39";"0";"3.13";"54";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2cc(O)c(O)c(O)c2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"20.42";"0.40";"6.17";"7.08";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL244406";"";"0";"412.53";"0";"4.34";"16i";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2cccc(C(=O)O)c2)CC1";"IC50";"'='";"1.9";"nM";"8.72";"";"";"UO_0000065";"21.14";"0.40";"4.38";"9.95";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL242025";"";"0";"451.44";"1";"6.09";"9e";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2c(Cl)cccc2Cl)CC1";"IC50";"'='";"1.5";"nM";"8.82";"";"";"UO_0000065";"19.55";"0.40";"2.73";"17.52";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL1632466";"";"0";"426.61";"0";"3.84";"25c";"O=C(Nc1ccc(OCCCCN2CCNCC2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"126.0";"nM";"6.90";"";"";"UO_0000065";"16.17";"0.30";"3.06";"10.51";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL552382";"";"0";"389.46";"0";"3.58";"entB-2d";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"176.0";"nM";"6.75";"";"";"UO_0000065";"17.34";"0.32";"3.17";"8.03";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL556507";"";"0";"428.49";"0";"3.28";"22";"CS(=O)(=O)c1ccc(C(CCNC(=O)c2ccc(O)nc2)c2ccc(F)cc2)cc1";"EC50";"'='";"2.1";"nM";"8.68";"";"";"UO_0000065";"20.25";"0.40";"5.40";"9.01";"False";"CHEMBL1058193";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL563417";"";"0";"368.38";"0";"4.02";"12";"O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccc(O)nc1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"22.53";"0.42";"4.28";"13.34";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL564893";"";"0";"450.41";"1";"5.25";"14";"O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccnc(OCC(F)(F)F)c1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"18.43";"0.35";"3.05";"16.21";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL551138";"";"0";"376.41";"0";"4.79";"15";"N#Cc1ccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(F)cc2)cc1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"22.05";"0.40";"3.51";"15.69";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL564145";"";"0";"412.49";"0";"3.58";"21";"CS(=O)(=O)c1ccc(C(CCNC(=O)c2cccnc2)c2ccc(F)cc2)cc1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"19.63";"0.38";"4.52";"10.64";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL2021563";"";"0";"427.50";"0";"3.89";"(R)-22";"CS(=O)(=O)c1ccc([C@H](CCNC(=O)c2ccc(O)cc2)c2ccc(F)cc2)cc1";"EC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"17.87";"0.35";"3.75";"9.15";"False";"CHEMBL1058193";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL418331";"";"0";"326.82";"0";"3.98";"5";"CCCCCOC(=O)CCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"2060.0";"nM";"5.69";"";"";"UO_0000065";"17.40";"0.35";"1.71";"8.43";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL396546";"";"0";"404.50";"0";"4.92";"16e";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2cc(F)cc(F)c2)CC1";"IC50";"'='";"0.82";"nM";"9.09";"";"";"UO_0000065";"22.46";"0.43";"4.17";"18.04";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL243125";"";"0";"447.42";"1";"5.41";"13a";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(Br)cc2)CC1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"19.44";"0.42";"3.29";"17.27";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL438269";"";"0";"516.68";"1";"3.52";"Table 3, r9c1";"CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"880.0";"nM";"6.06";"";"";"UO_0000065";"11.72";"0.22";"2.54";"4.43";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL220415";"";"0";"242.32";"0";"1.57";"Table 1, r9c1";"COC(=O)CCCNC(=O)NC1CCCCC1";"IC50";"'='";"6200.0";"nM";"5.21";"";"";"UO_0000065";"21.49";"0.42";"3.64";"7.72";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL68115";"";"0";"478.67";"1";"5.26";"34";"CCOC(=O)CCCCCCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"14.62";"0.28";"1.74";"7.47";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL3322826";"";"0";"406.55";"0";"4.29";"BDBM50057638";"CCCCCNC(=O)NCCCCCOc1cccc2sc(NC(C)=O)nc12";"IC50";"'>'";"500.0";"nM";"";"";"326404";"UO_0000065";"";"";"";"";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL1668929";"";"0";"323.48";"0";"2.90";"14h";"CC(=O)N1CCC(NC(=O)NC2CCC(C(C)(C)C)CC2)CC1";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"24.38";"0.47";"4.99";"12.84";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL66518";"";"0";"214.26";"0";"0.79";"2";"COC(=O)CNC(=O)NC1CCCCC1";"IC50";"'='";"70000.0";"nM";"4.16";"";"";"UO_0000065";"19.39";"0.38";"3.36";"6.16";"True";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL68115";"";"0";"478.67";"1";"5.26";"34";"CCOC(=O)CCCCCCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC90";"'='";"680.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677486";"Tested for 90 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL478505";"";"0";"328.41";"0";"3.56";"13";"COC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"4.1";"nM";"8.39";"";"";"UO_0000065";"25.54";"0.48";"4.83";"12.44";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL396760";"";"0";"402.54";"0";"4.21";"29";"CCOCCOCCOc1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"21.72";"0.41";"4.53";"12.71";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL477872";"";"0";"286.38";"0";"3.48";"4";"O=C(Nc1ccc(O)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"24.0";"nM";"7.62";"";"";"UO_0000065";"26.61";"0.50";"4.14";"12.42";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL478321";"";"0";"314.39";"0";"3.48";"15";"O=C(Nc1ccc(C(=O)O)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1411.0";"nM";"5.85";"";"";"UO_0000065";"18.61";"0.35";"2.37";"7.46";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL478146";"";"0";"396.54";"0";"3.16";"18";"CN1CCN(C(=O)c2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"35.0";"nM";"7.46";"";"";"UO_0000065";"18.80";"0.35";"4.30";"11.53";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470822";"";"0";"483.46";"1";"5.01";"6-22";"CC(C)(C)c1ccc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"Inhibition";"'='";"85.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL476614";"";"0";"344.41";"0";"3.27";"6";"COC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1O";"IC50";"'='";"2.8";"nM";"8.55";"";"";"UO_0000065";"24.83";"0.47";"5.28";"9.76";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL477067";"";"0";"300.40";"0";"3.79";"13, 80";"COc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"26.14";"0.49";"4.06";"15.60";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031817";"";"0";"374.48";"1";"5.01";"39";"O=C(Nc1cccc(C(=O)c2ccccc2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.7";"nM";"8.57";"";"";"UO_0000065";"22.88";"0.42";"3.56";"14.72";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031946";"";"0";"410.60";"0";"3.88";"107";"CC(C)OCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"4.1";"nM";"8.39";"";"";"UO_0000065";"20.43";"0.39";"4.51";"12.19";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL418331";"";"0";"326.82";"0";"3.98";"9";"CCCCCOC(=O)CCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"2100.0";"nM";"5.68";"";"";"UO_0000065";"17.37";"0.35";"1.70";"8.42";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL2436559";"";"0";"471.59";"0";"4.96";"7";"O=C(NC12CC3CC(CC(C3)C1)C2)N1CCC2(CC1)CCN(C(=O)c1c(F)cccc1F)CC2";"IC50";"'='";"466.3";"nM";"6.33";"";"";"UO_0000065";"13.43";"0.25";"1.37";"12.03";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1257878";"";"0";"305.38";"0";"2.22";"15";"CCC(=O)N1CCC(NC(=O)Nc2ccc(OC)cc2)CC1";"IC50";"'='";"87.0";"nM";"7.06";"";"";"UO_0000065";"23.12";"0.44";"4.84";"9.99";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"22.41";"0.43";"3.56";"11.21";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL3617998";"";"0";"580.54";"3";"-2.94";"7, aloinoside D";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@](O)([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"IC50";"'='";"12500.0";"nM";"4.90";"";"";"UO_0000065";"8.45";"0.16";"7.84";"1.98";"False";"CHEMBL3620669";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"107.0";"nM";"6.97";"Potential transcription error";"";"UO_0000065";"";"";"";"";"True";"CHEMBL2162306";"Inhibition of sEH using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to substrate addition measured every min for 15 mins by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2157944";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL3322802";"";"0";"479.69";"1";"5.05";"7";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)NS(=O)(=O)c1ccccc1";"IC50";"'='";"41.0";"nM";"7.39";"";"";"UO_0000065";"15.40";"0.31";"2.34";"7.08";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322823";"";"0";"397.59";"0";"4.50";"28";"CCCCCNC(=O)NCCCC/C=C\CCCCCC1SC(=O)NC1=O";"IC50";"'='";"57.0";"nM";"7.24";"";"";"UO_0000065";"18.22";"0.37";"2.74";"8.30";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL2436566";"";"0";"467.44";"1";"5.14";"14";"O=C(Nc1cccc(C(F)(F)F)c1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"16.1";"nM";"7.79";"";"";"UO_0000065";"16.67";"0.32";"2.65";"14.80";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3765360";"";"0";"357.43";"0";"3.89";"7b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccc(F)cc2)cc1";"IC50";"'='";"2200.0";"nM";"5.66";"";"";"UO_0000065";"15.83";"0.30";"1.77";"10.21";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL1933662";"";"0";"422.55";"0";"2.70";"14-45";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1";"IC50";"'='";"224.0";"nM";"6.65";"";"";"UO_0000065";"15.74";"0.31";"3.95";"7.83";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933670";"";"0";"346.45";"0";"3.52";"15-2";"O=C(NC1CCCCCC1)C1CCN(C(=O)c2ccc(F)cc2)CC1";"IC50";"'='";"1400.0";"nM";"5.85";"";"";"UO_0000065";"16.90";"0.32";"2.33";"11.85";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL560030";"";"0";"340.51";"0";"4.63";"19";"CCNC(=O)NCCCC/C=C\CCCCCCCCCC(=O)O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL1804587";"Inhibition of soluble epoxide hydrolase at 1 to 5 uM";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1799995";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL3633674";"";"0";"345.49";"0";"4.16";"3i";"CC(C)c1cc(CN(C)C(=O)NCC23CC4CC(CC(C4)C2)C3)no1";"IC50";"'='";"575.8";"nM";"6.24";"";"";"UO_0000065";"18.06";"0.34";"2.08";"10.69";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3236508";"";"0";"448.51";"1";"-1.21";"7";"CC1=CC[C@@H](C(C)(C)O[C@@H]2O[C@H](CO[C@@H]3OC[C@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)CC1";"Inhibition";"'<'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3236510";"";"0";"752.59";"3";"1.72";"10";"O=C(O[C@@H]1[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)O[C@H](CO)[C@H]1O)c1cc(O)c(O)c(O)c1";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL6246";"ELLAGIC ACID";"2";"302.19";"0";"1.31";"24";"O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3401637";"";"0";"335.45";"0";"2.89";"17";"CN1CCN(C(=O)N[C@H]2[C@H](c3ccccc3)[C@@H]2c2ccccc2)CC1";"IC50";"'='";"14.4";"nM";"7.84";"";"";"UO_0000065";"23.38";"0.43";"4.95";"22.04";"False";"CHEMBL3406976";"Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400076";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3401636";"";"0";"320.44";"0";"4.13";"16";"O=C(N[C@H]1[C@H](c2ccccc2)[C@@H]1c1ccccc1)N1CCCCC1";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"27.29";"0.50";"4.61";"27.04";"False";"CHEMBL3406976";"Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400076";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL1258337";"";"0";"401.25";"0";"2.81";"27";"CCC(=O)N1CCC(NC(=O)Nc2ccc(I)cc2)CC1";"IC50";"'='";"7.2";"nM";"8.14";"";"";"UO_0000065";"20.29";"0.53";"5.33";"13.25";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258556";"";"0";"309.80";"0";"2.86";"31";"CCC(=O)N1CCC(NC(=O)Nc2ccccc2Cl)CC1";"IC50";"'='";"1100.0";"nM";"5.96";"";"";"UO_0000065";"19.23";"0.39";"3.10";"9.70";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258558";"";"0";"344.24";"0";"3.52";"33";"CCC(=O)N1CCC(NC(=O)Nc2cc(Cl)cc(Cl)c2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"27.30";"0.58";"5.88";"15.30";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL218954";"";"0";"471.60";"0";"3.33";"Table 2, r17c3";"O=C(CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1ccc(O)cc1)C(=O)O";"IC50";"'='";"80000.0";"nM";"4.10";"";"";"UO_0000065";"8.69";"0.16";"0.77";"3.21";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL216220";"";"0";"421.58";"0";"3.43";"Table 2, r9c3";"CCC(C)[C@H](NC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL2424989";"";"0";"423.54";"0";"3.60";"6a";"Cc1cc(C2CCN(C(=O)c3ccccc3)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"6.5";"nM";"8.19";"";"";"UO_0000065";"20.85";"0.40";"2.95";"10.44";"False";"CHEMBL2427204";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2425004";"";"0";"445.59";"0";"3.05";"8e";"Cc1cc(C2CCN(C(=O)NC3CCCCC3)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"Inhibition";"'='";"98.95";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL3765679";"";"0";"431.53";"1";"5.54";"12b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccc(Oc3ccccc3)cc2)cc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3233609";"";"0";"288.37";"0";"2.84";"10";"O=C(Nc1ccccc1N1CCOCC1)c1ccsc1";"IC50";"'='";"171000.0";"nM";"3.77";"";"";"UO_0000065";"13.06";"0.26";"0.93";"9.06";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"1";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.2";"nM";"8.49";"";"";"UO_0000065";"21.64";"0.41";"3.25";"10.83";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224448";"";"0";"448.69";"1";"6.35";"10";"CC(C)COC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"19.88";"0.38";"2.57";"13.23";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL375240";"";"0";"432.65";"1";"5.88";"5";"C=CCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"20.80";"0.40";"3.12";"13.35";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL216592";"";"0";"550.70";"1";"3.72";"Table 3, r11c1";"O=C(CCCCCNC(=O)NC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"12.71";"0.24";"3.28";"5.12";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL265624";"";"0";"532.64";"2";"2.34";"Table 3,r5c1";"O=C(O)CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL376653";"";"0";"455.60";"0";"3.63";"Table 2, r12c3";"O=C(CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1ccccc1)C(=O)O";"IC50";"'='";"2700.0";"nM";"5.57";"";"";"UO_0000065";"12.22";"0.23";"1.94";"5.18";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL66380";"";"0";"200.24";"0";"0.70";"Table 1, r1c1";"O=C(O)CNC(=O)NC1CCCCC1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1594316";"";"0";"224.26";"0";"3.01";"g";"COc1ccc(-c2cn3ccccc3n2)cc1";"IC50";"'='";"75000.0";"nM";"4.12";"";"";"UO_0000065";"18.39";"0.33";"1.11";"15.55";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL3322797";"";"0";"472.67";"0";"4.11";"BDBM50057420";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)OCCOCCOCCO";"IC50";"'='";"255.0";"nM";"6.59";"";"423456";"UO_0000065";"13.95";"0.27";"2.48";"6.21";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3114595";"";"0";"404.43";"0";"4.81";"17";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccccc2C(F)(F)F)CC1";"IC50";"'='";"2.1";"nM";"8.68";"";"";"UO_0000065";"21.46";"0.41";"3.87";"20.88";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114618";"";"0";"370.88";"0";"4.45";"11";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccccc2Cl)CC1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"23.45";"0.46";"4.25";"20.93";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL1076347";"TRICLOCARBAN";"4";"315.59";"1";"5.29";"Figure 2B, R2C2";"O=C(Nc1ccc(Cl)cc1)Nc1ccc(Cl)c(Cl)c1";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"24.99";"0.57";"2.60";"19.17";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL3322812";"";"0";"413.59";"0";"3.35";"BDBM50057491";"CCCCCNC(=O)NCCCC/C=C\CCCCCS(=O)(=O)c1ncn[nH]1";"IC50";"'='";"23.0";"nM";"7.64";"";"326391";"UO_0000065";"18.47";"0.37";"4.29";"6.54";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL244192";"";"0";"398.55";"0";"4.65";"16b";"COc1ccc(O[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1";"IC50";"'='";"0.55";"nM";"9.26";"";"";"UO_0000065";"23.23";"0.44";"4.61";"15.54";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL242026";"";"0";"476.61";"1";"5.85";"9g";"CC(C)Oc1cc(F)c(CO[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c(F)c1";"IC50";"'='";"3.5";"nM";"8.46";"";"";"UO_0000065";"17.74";"0.34";"2.61";"14.19";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL244193";"";"0";"413.52";"0";"4.55";"16c";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc([N+](=O)[O-])cc2)CC1";"IC50";"'='";"0.72";"nM";"9.14";"";"";"UO_0000065";"22.11";"0.42";"4.59";"9.78";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL397426";"";"0";"396.58";"1";"5.09";"9c";"Cc1ccccc1CO[C@H]1CC[C@@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"3.4";"nM";"8.47";"";"";"UO_0000065";"21.35";"0.40";"3.38";"16.82";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL1258556";"";"0";"309.80";"0";"2.86";"BDBM50327837";"CCC(=O)N1CCC(NC(=O)Nc2ccccc2Cl)CC1";"IC50";"'='";"1100.0";"nM";"5.96";"";"377034";"UO_0000065";"19.23";"0.39";"3.10";"9.70";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3401632";"";"0";"422.53";"0";"4.06";"12";"C[C@H]1[C@H](NC(=O)N2CCC(Oc3ccc(CCC(=O)O)cc3)CC2)[C@H]1c1ccccc1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"18.75";"0.35";"3.86";"10.04";"False";"CHEMBL3406976";"Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400076";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL1933505";"";"0";"408.52";"0";"2.62";"14-15";"O=C(O)c1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"240.0";"nM";"6.62";"";"";"UO_0000065";"16.20";"0.32";"4.00";"6.38";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL3765690";"";"0";"341.41";"0";"3.28";"10c";"CCC(Cc1ccc(C(=O)NCc2ccc(OC)cc2)cc1)C(=O)O";"Inhibition";"'='";"34.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3767858";"Inhibition of human recombinant sEH using PHOME as substrate at 10 uM preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3236509";"";"0";"788.58";"3";"0.70";"9";"O=C(OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](O)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1";"IC50";"'='";"36140.0";"nM";"4.44";"";"";"UO_0000065";"5.63";"0.11";"3.74";"1.18";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL459260";"";"0";"616.48";"3";"0.44";"12";"O=C(O[C@H]1[C@H](Oc2c(-c3ccc(O)c(O)c3)oc3cc(O)cc(O)c3c2=O)O[C@H](CO)[C@@H](O)[C@@H]1O)c1cc(O)c(O)c(O)c1";"IC50";"'='";"18050.0";"nM";"4.74";"";"";"UO_0000065";"7.69";"0.15";"4.30";"1.71";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL6246";"ELLAGIC ACID";"2";"302.19";"0";"1.31";"24";"O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23";"IC50";"'='";"20700.0";"nM";"4.68";"";"";"UO_0000065";"15.50";"0.29";"3.37";"3.31";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL242459";"";"0";"412.53";"0";"4.34";"t-AUCB";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"22.55";"0.42";"4.96";"10.61";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766293";"";"0";"514.53";"2";"5.28";"11e";"CS(=O)(=O)c1ccc(-n2nc(CNC(=O)Nc3ccc(C(F)(F)F)cc3)cc2-c2ccccc2)cc1";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"13.52";"0.26";"1.68";"7.48";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766295";"";"0";"515.52";"1";"4.53";"11g";"NS(=O)(=O)c1ccc(-n2nc(CNC(=O)Nc3cccc(C(F)(F)F)c3)cc2-c2ccccc2)cc1";"IC50";"'='";"84.0";"nM";"7.08";"";"";"UO_0000065";"13.73";"0.27";"2.55";"5.94";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766297";"";"0";"501.49";"1";"4.85";"7";"NS(=O)(=O)c1ccc(-n2nc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2-c2ccccc2)cc1";"IC50";"'='";"88.0";"nM";"7.06";"";"";"UO_0000065";"14.07";"0.28";"2.21";"5.92";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL122";"ROFECOXIB";"4";"314.36";"0";"2.56";"rofecoxib";"CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1";"IC50";"'>'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL3103816";"";"0";"413.52";"0";"2.87";"23";"CON(C)C(=O)C(=O)Nc1ccc(CNC(=O)CC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"69.0";"nM";"7.16";"";"";"UO_0000065";"17.32";"0.33";"4.29";"8.16";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL460838";"";"0";"442.60";"0";"3.69";"16b";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)C(O)CC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"17.26";"0.33";"3.95";"10.75";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL460429";"";"0";"454.61";"0";"4.29";"17c";"O=C(CCC12CC3CC(CC(C3)C1)C2)C(=O)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"48.0";"nM";"7.32";"";"";"UO_0000065";"16.10";"0.30";"3.03";"10.78";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL552469";"";"0";"334.46";"0";"3.16";"14a";"CC(C)(C)CC(=O)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"1550.0";"nM";"5.81";"";"";"UO_0000065";"17.37";"0.33";"2.65";"11.44";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL551396";"";"0";"355.44";"0";"2.36";"14p";"O=C(Cc1cccnc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"14000.0";"nM";"4.85";"";"";"UO_0000065";"13.66";"0.25";"2.49";"7.62";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL551921";"";"0";"439.52";"0";"4.73";"2j";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"18.55";"0.34";"3.42";"9.69";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL560662";"";"0";"441.43";"0";"4.59";"13i";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(F)c(OCCCN2CCOCC2)c1";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"20.13";"0.39";"4.30";"14.14";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL552381";"";"0";"389.46";"0";"3.19";"3d";"O=C(NC1Cc2ccccc2C1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"130.0";"nM";"6.89";"";"";"UO_0000065";"17.68";"0.32";"3.70";"8.18";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL551806";"";"0";"430.56";"0";"4.47";"15c";"O=C(CC12CC3CC(CC(C3)C1)C2)Nc1ccc(F)c(OCCCN2CCOCC2)c1";"IC50";"'='";"6.6";"nM";"8.18";"";"";"UO_0000065";"19.00";"0.36";"3.71";"16.10";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL561664";"";"0";"456.44";"0";"4.01";"15k";"O=C(Cc1ccc(OC(F)(F)F)cc1)Nc1ccc(F)c(OCCCN2CCOCC2)c1";"IC50";"'='";"145.0";"nM";"6.84";"";"";"UO_0000065";"14.98";"0.29";"2.83";"11.39";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL589136";"";"0";"381.26";"0";"3.54";"1, Table1";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ncccn2)CC1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"20.31";"0.42";"4.20";"11.50";"False";"CHEMBL1118603";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1085743";"";"0";"422.48";"0";"4.48";"7, Table1";"O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)N1CCC(c2cnccn2)C1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"19.88";"0.37";"3.92";"14.45";"False";"CHEMBL1118602";"Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL3634700";"";"0";"556.52";"3";"-1.94";"13";"COc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(OC)c(C(C)=O)c(O[C@H]3OC[C@@](O)(CO)[C@@H]3O)cc2c1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL216165";"";"0";"490.60";"1";"1.47";"Table 3, r13c1";"O=C(CCCCCNC(=O)NC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O";"IC50";"'='";"2400.0";"nM";"5.62";"";"";"UO_0000065";"11.45";"0.22";"4.15";"3.58";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219153";"";"0";"460.58";"0";"2.11";"Table 3,r6c1";"O=C(O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)NC1CCCCC1";"IC50";"'='";"1500.0";"nM";"5.82";"";"";"UO_0000065";"12.64";"0.24";"3.71";"4.26";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219498";"";"0";"518.61";"2";"1.95";"Table 3,r4c1";"O=C(O)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3322803";"";"0";"417.62";"0";"3.62";"BDBM50057446";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)NS(C)(=O)=O";"IC50";"'='";"71.0";"nM";"7.15";"";"326382";"UO_0000065";"17.12";"0.35";"3.53";"6.85";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL436774";"AR9281";"2";"319.45";"0";"2.27";"14a, AR9281";"CC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"57.0";"nM";"7.24";"";"";"UO_0000065";"22.68";"0.43";"4.97";"11.79";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL245067";"PHLORIZIN";"0";"436.41";"1";"-0.20";"14";"O=C(CCc1ccc(O)cc1)c1c(O)cc(O)cc1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O";"IC50";"'='";"41720.0";"nM";"4.38";"";"";"UO_0000065";"10.04";"0.19";"4.58";"2.47";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3322814";"";"0";"364.54";"0";"3.91";"19";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1nnn[nH]1";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"21.83";"0.42";"4.05";"8.33";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1364973";"";"0";"295.30";"0";"1.92";"8";"COc1ccc(NC(=O)c2cccc(-n3cnnn3)c2)cc1";"IC50";"'='";"1600.0";"nM";"5.80";"";"";"UO_0000065";"19.63";"0.36";"3.88";"7.07";"False";"CHEMBL2039369";"Inhibition of soluble epoxide hydrolase using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to substrate addition measured every min for 15 mins by fluorometry";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2034900";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None"
"CHEMBL11658";"";"0";"340.60";"1";"6.28";"328";"CCCCCCCCCCCCNC(=O)NCC(C)(C)C(C)(C)C";"IC50";"'='";"2.36";"";"";"Non standard unit for type";"";"";"";"";"";"";"False";"CHEMBL809079";"Inhibitory activity against human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1136721";"1";"Scientific Literature";"J. Med. Chem.";"2003";"None"
"CHEMBL2037376";"";"0";"299.38";"0";"2.98";"7";"Cn1nnc2cc(NC(=O)NCCC3=CCCCC3)ccc21";"IC50";"'='";"470.0";"nM";"6.33";"";"";"UO_0000065";"21.14";"0.39";"3.35";"8.81";"False";"CHEMBL2039369";"Inhibition of soluble epoxide hydrolase using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to substrate addition measured every min for 15 mins by fluorometry";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2034900";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None"
"CHEMBL2037377";"";"0";"285.34";"0";"3.19";"9";"COc1ccc(CC(=O)Nc2ccc(C)cc2)cc1OC";"IC50";"'='";"21000.0";"nM";"4.68";"";"";"UO_0000065";"16.39";"0.30";"1.49";"9.84";"False";"CHEMBL2039369";"Inhibition of soluble epoxide hydrolase using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to substrate addition measured every min for 15 mins by fluorometry";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2034900";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None"
"CHEMBL3402234";"";"0";"215.30";"0";"1.75";"Fragment 1";"Cn1ccc(CNCCc2ccccc2)n1";"IC50";"'='";"800000.0";"nM";"3.10";"";"";"UO_0000065";"14.38";"0.26";"1.35";"10.37";"False";"CHEMBL3406221";"Inhibition of C-terminal His6-tagged full-length human soluble epoxide hydrolase expressed in Escherichia coli BL21(DE3) cells pre-incubated for 15 mins before addition of PHOME substrate and measured 50 mins after substrate addition by microplate reader based fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400124";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL4125964";"";"0";"420.67";"1";"6.41";"3e";"S=C(Nc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1248.0";"nM";"5.90";"";"";"UO_0000065";"14.03";"0.27";"-0.51";"24.54";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL3322817";"";"0";"380.53";"0";"4.07";"BDBM50057506";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1noc(=O)[nH]1";"IC50";"'='";"65.0";"nM";"7.19";"";"423477";"UO_0000065";"18.89";"0.36";"3.12";"7.19";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322822";"";"0";"396.60";"0";"4.54";"BDBM50057634";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1nsc(=O)[nH]1";"IC50";"'='";"231.0";"nM";"6.64";"";"423483";"UO_0000065";"16.73";"0.34";"2.10";"7.64";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322825";"";"0";"447.65";"1";"6.01";"BDBM50057637";"CCCCCCC(=O)N(CCCCCOc1cccc2sc(NC(C)=O)nc12)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"423484";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL118";"CELECOXIB";"4";"381.38";"0";"3.51";"celecoxib";"Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1";"IC50";"'>'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766301";"";"0";"557.60";"2";"5.27";"21c";"Cc1ccc(-c2cc(CCCNC(=O)Nc3cccc(C(F)(F)F)c3)nn2-c2ccc(S(N)(=O)=O)cc2)cc1";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"14.35";"0.28";"2.73";"6.72";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766286";"";"0";"510.02";"1";"4.59";"21h";"NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3ccc(Cl)cc3)cc2-c2ccccc2)cc1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"17.84";"0.35";"4.51";"7.64";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL4128911";"";"0";"332.49";"0";"4.72";"1p";"CC(NC(=S)Nc1ccc(F)cc1)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1084.0";"nM";"5.96";"";"";"UO_0000065";"17.94";"0.35";"1.24";"24.79";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4130060";"";"0";"332.49";"0";"4.72";"1m";"Fc1cccc(NC(=S)NCCC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"160.0";"nM";"6.80";"";"";"UO_0000065";"20.44";"0.40";"2.08";"28.25";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL396736";"";"0";"364.57";"1";"5.02";"11";"CCCCC(C)OCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"21.83";"0.42";"2.94";"15.80";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245127";"";"0";"336.52";"0";"4.24";"4";"CCCCCCOCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"5.6";"nM";"8.25";"";"";"UO_0000065";"24.52";"0.47";"4.01";"16.39";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL388004";"";"0";"336.52";"0";"4.24";"2";"CCCCCCCOCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"29.0";"nM";"7.54";"";"";"UO_0000065";"22.40";"0.43";"3.30";"14.97";"True";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL4130278";"";"0";"332.49";"0";"4.72";"1q";"Fc1ccc(NC(=S)NCCC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"148.0";"nM";"6.83";"";"";"UO_0000065";"20.54";"0.41";"2.11";"28.39";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL3677985";"";"0";"494.51";"0";"4.97";"BDBM158496";"CCN(CC)C(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"301055";"UO_0000065";"18.81";"0.36";"4.33";"10.02";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4104176";"";"0";"269.30";"0";"2.62";"8";"Cc1ccc(C(=O)NCc2ccc(C(=O)O)cc2)cc1";"Inhibition";"'='";"24.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL195797";"";"0";"247.34";"0";"2.17";"e-3";"O=C(Cc1ccccc1CO)NC1CCCCC1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL375967";"";"0";"407.56";"0";"3.04";"Table 2, r18c3";"CC(C)[C@H](NC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'='";"55000.0";"nM";"4.26";"";"";"UO_0000065";"10.45";"0.20";"1.22";"3.96";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL578048";"";"0";"294.23";"0";"4.47";"7m";"FC(F)(F)Oc1ccc(Nc2noc3ccccc23)cc1";"IC50";"'='";"60.0";"nM";"7.22";"";"";"UO_0000065";"24.54";"0.47";"2.75";"15.27";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL578771";"";"0";"294.23";"0";"4.47";"7o";"FC(F)(F)Oc1ccccc1Nc1noc2ccccc12";"IC50";"'='";"5200.0";"nM";"5.28";"";"";"UO_0000065";"17.96";"0.34";"0.81";"11.17";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL577696";"";"0";"369.35";"1";"5.96";"7bb";"Cc1cccnc1-c1ccc2c(Nc3ccc(C(F)(F)F)cc3)noc2c1";"IC50";"'='";"70.0";"nM";"7.16";"";"";"UO_0000065";"19.37";"0.36";"1.19";"14.04";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL589860";"";"0";"457.38";"0";"4.15";"42";"CS(=O)(=O)c1ccccc1OC1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"EC50";"'='";"1.65";"nM";"8.78";"";"";"UO_0000065";"19.20";"0.41";"4.63";"11.60";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL4215208";"";"0";"528.53";"2";"6.45";"24";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)OCc3ccccc3)cc2)CC1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"16.13";"0.31";"2.07";"9.92";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4128027";"";"0";"342.55";"0";"4.44";"1f";"CC12CC3CC(C)(C1)CC(NC(=S)NCCc1ccccc1)(C3)C2";"IC50";"'='";"216.0";"nM";"6.67";"";"";"UO_0000065";"19.46";"0.38";"2.23";"27.70";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1257759";"";"0";"457.47";"0";"3.87";"BDBM50327850";"Cc1ccc(S(=O)(=O)N2CCC(NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"0.4";"nM";"9.40";"";"377055";"UO_0000065";"20.54";"0.41";"5.53";"10.71";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3263289";"";"0";"498.76";"1";"5.58";"1c";"O=C(NCCCCCCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2";"T1/2";"'='";"0.1667";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3270576";"Displacement of ACPU from recombinant human soluble epoxide hydrolase assessed as compound residence time after 1.5 hrs by FRET assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263303";"";"0";"328.50";"0";"4.22";"DAU";"O=C(NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"27.16";"0.51";"4.70";"21.69";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4126370";"";"0";"318.46";"0";"4.33";"1o";"Fc1ccc(NC(=S)NCC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"159.0";"nM";"6.80";"";"";"UO_0000065";"21.35";"0.42";"2.47";"28.26";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4129276";"";"0";"342.55";"0";"4.30";"1h";"CC(NC(=S)NCCc1ccccc1)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"345.0";"nM";"6.46";"";"";"UO_0000065";"18.86";"0.37";"2.16";"26.86";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4129824";"";"0";"344.57";"0";"4.10";"5";"S=C(NC1C2CC3CC(C2)CC1C3)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"131.0";"nM";"6.88";"";"";"UO_0000065";"19.97";"0.39";"2.78";"28.61";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1668925";"";"0";"307.44";"0";"2.27";"14d";"CC(=O)N1CCC(NC(=O)NC2CC3(C)CCC2CC3)CC1";"IC50";"'='";"300.0";"nM";"6.52";"";"";"UO_0000065";"21.22";"0.40";"4.25";"10.62";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL1668934";"";"0";"345.32";"0";"2.72";"14m";"CC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"59.0";"nM";"7.23";"";"";"UO_0000065";"20.93";"0.41";"4.51";"10.23";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL2436577";"";"0";"463.46";"0";"3.84";"25";"Cc1cnc(C(=O)N2CCC3(CCN(C(=O)Nc4ccc(OC(F)(F)F)cc4)C3)CC2)cn1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"20.28";"0.39";"5.56";"10.72";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436570";"";"0";"447.91";"1";"5.09";"18";"Cc1cc(NC(=O)N2CCC3(CCN(C(=O)c4c(F)cccc4F)CC3)C2)ccc1Cl";"IC50";"'='";"3.4";"nM";"8.47";"";"";"UO_0000065";"18.91";"0.37";"3.38";"16.08";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL191982";"";"0";"247.34";"0";"3.09";"e-2";"O=C(CC1CCCCC1)Nc1ccccc1CO";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL364020";"";"0";"327.81";"0";"3.94";"10";"CCCCCOC(=O)CCCNC(=O)Oc1cccc(Cl)c1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL4126744";"";"0";"558.95";"2";"6.97";"6h";"S=C(NCCCCCCCCCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"15.3";"nM";"7.82";"";"";"UO_0000065";"13.98";"0.28";"0.85";"16.24";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4128756";"";"0";"502.84";"2";"5.41";"6e";"S=C(NCCCCCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"7.7";"nM";"8.11";"";"";"UO_0000065";"16.14";"0.33";"2.70";"16.86";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL3322820";"";"0";"410.58";"0";"3.98";"25";"CCCCNC(=O)C(=O)NCCCC/C=C\CCCCCCc1noc(=S)[nH]1";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322825";"";"0";"447.65";"1";"6.01";"30";"CCCCCCC(=O)N(CCCCCOc1cccc2sc(NC(C)=O)nc12)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL2180631";"";"0";"407.51";"0";"4.00";"6d";"O=C(NCc1ccccc1Cn1cccc1C(=O)O)NC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3";"IC50";"'='";"178.0";"nM";"6.75";"";"";"UO_0000065";"16.56";"0.31";"2.75";"8.10";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL388015";"";"0";"380.46";"1";"5.71";"34";"O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"22.98";"0.43";"3.03";"17.36";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL388004";"";"0";"336.52";"0";"4.24";"72";"CCCCCCCOCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"29.4";"nM";"7.53";"";"";"UO_0000065";"22.38";"0.43";"3.29";"14.96";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031930";"";"0";"408.45";"0";"4.31";"78";"CCOC(=O)C(F)(F)Oc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"22.27";"0.43";"4.79";"11.87";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL3233606";"";"0";"269.17";"0";"3.08";"6";"Nc1ncc(Cc2ccc(Br)cc2)s1";"IC50";"'='";"70000.0";"nM";"4.16";"";"";"UO_0000065";"15.44";"0.41";"1.07";"10.68";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL590600";"";"0";"353.34";"0";"4.26";"1";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC(n2cccc2)CC1";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"22.52";"0.43";"3.70";"17.12";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL603530";"";"0";"318.30";"0";"2.82";"4";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCCC(CO)C1";"IC50";"'='";"19.0";"nM";"7.72";"";"";"UO_0000065";"24.26";"0.48";"4.90";"12.49";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL591554";"";"0";"318.30";"0";"2.96";"5";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCCCC1CO";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"21.86";"0.43";"4.00";"11.26";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL601095";"";"0";"317.22";"0";"2.91";"17";"O=C(NCc1ccc(Cl)c(Cl)c1)N1CCCC(CO)C1";"IC50";"'='";"200.0";"nM";"6.70";"";"";"UO_0000065";"21.12";"0.46";"3.79";"12.74";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2348404";"";"0";"398.42";"0";"3.16";"3d";"CC(C)(C)OC(=O)NC(Cc1ccccc1)C(=O)Oc1cccc2oc(=O)[nH]c12";"IC50";"'='";"2670.0";"nM";"5.57";"";"";"UO_0000065";"13.99";"0.26";"2.41";"5.04";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348398";"";"0";"305.31";"0";"2.20";"5i";"Cc1cccc(S(=O)(=O)Oc2cccc3oc(=O)[nH]c23)c1";"Inhibition";"'='";"30.95";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348391";"";"0";"325.73";"0";"2.54";"5b";"O=c1[nH]c2c(OS(=O)(=O)c3ccccc3Cl)cccc2o1";"Inhibition";"'='";"15.21";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348403";"";"0";"350.37";"0";"2.58";"3c";"CC(C)C(NC(=O)OC(C)(C)C)C(=O)Oc1cccc2oc(=O)[nH]c12";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3322807";"";"0";"406.64";"1";"6.26";"BDBM50057466";"CCCCCNC(=O)NCCCC/C=C\CCCCCSc1ccccc1O";"IC50";"'='";"6.0";"nM";"8.22";"";"326386";"UO_0000065";"20.22";"0.40";"1.96";"13.40";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL1271608";"";"0";"409.37";"0";"4.60";"15";"O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cn1)c1ccccc1";"IC50";"'='";"4.7";"nM";"8.33";"";"";"UO_0000065";"20.34";"0.38";"3.73";"11.46";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1271658";"";"0";"409.37";"0";"4.60";"18";"O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)nc1)c1ccccc1";"IC50";"'='";"9.9";"nM";"8.00";"";"";"UO_0000065";"19.55";"0.36";"3.40";"11.01";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1271550";"";"0";"408.38";"1";"5.21";"4";"O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cc1)c1ccccc1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"22.04";"0.41";"3.79";"15.05";"False";"CHEMBL1273200";"Displacement of [3H]-cDPPO from human Ephx2 by cell-based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL562926";"";"0";"417.51";"0";"3.97";"3b";"O=C(NC1CCc2ccccc2CC1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"36.0";"nM";"7.44";"";"";"UO_0000065";"17.83";"0.33";"3.47";"8.85";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL559531";"";"0";"432.48";"0";"3.88";"2c";"O=C(O)c1ccc(-c2noc(C3CCN(C(=O)NC4CC4c4ccccc4)CC3)n2)cc1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"19.19";"0.35";"4.42";"7.65";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL3322806";"";"0";"398.55";"0";"4.04";"11";"CCCCCNC(=O)NCCCC/C=C\CCCCCCS(=O)(=O)[O-].[Na+]";"IC50";"'='";"57.0";"nM";"7.24";"";"";"UO_0000065";"19.24";"0.40";"3.20";"7.59";"False";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1257405";"";"0";"371.36";"0";"3.11";"52";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C2CC2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"25.31";"0.49";"6.29";"13.30";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL2313173";"";"0";"417.49";"0";"3.25";"7-35";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc([N+](=O)[O-])cc3)CC2)c(C)c1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"18.97";"0.37";"4.67";"7.23";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313187";"";"0";"479.64";"0";"3.22";"7-4";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCN(C(=O)OC(C)(C)C)CC3)CC2)c(C)c1";"IC50";"'='";"263.0";"nM";"6.58";"";"";"UO_0000065";"13.72";"0.27";"3.36";"6.85";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1087853";"";"0";"409.36";"0";"3.94";"5c,para isomer";"O=C(O)CCCNC(=O)c1ccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)cc1";"IC50";"'='";"19.0";"nM";"7.72";"";"";"UO_0000065";"18.86";"0.36";"3.78";"7.18";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1632470";"";"0";"526.72";"2";"5.49";"21b";"CC(C)(C)OC(=O)N1CCN(CCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"7.1";"nM";"8.15";"";"";"UO_0000065";"15.47";"0.29";"2.66";"9.80";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL2180630";"";"0";"355.44";"0";"3.37";"6c";"O=C(NCc1ccc(Cn2cccc2C(=O)O)cc1)NC1CCCCC1";"IC50";"'='";"252.0";"nM";"6.60";"";"";"UO_0000065";"18.56";"0.35";"3.23";"7.92";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL3809780";"";"0";"294.40";"0";"3.61";"8g(S)";"O=C(NCCCc1ccccc1)N[C@H]1CCc2ccccc21";"IC50";"'='";"65.0";"nM";"7.19";"";"";"UO_0000065";"24.41";"0.45";"3.58";"17.47";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3809946";"";"0";"296.41";"0";"4.07";"8e(R)";"CC[C@@H](NC(=O)NCCCc1ccccc1)c1ccccc1";"IC50";"'='";"4500.0";"nM";"5.35";"";"";"UO_0000065";"18.04";"0.33";"1.28";"13.00";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3103814";"";"0";"413.52";"0";"2.50";"21";"CON(C)C(=O)C(=O)N(C)c1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"204.0";"nM";"6.69";"";"";"UO_0000065";"16.18";"0.30";"4.19";"8.47";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL385457";"";"0";"589.74";"2";"4.20";"Table 3,r15c1";"O=C(CCCCCNC(=O)NC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"11.87";"0.22";"2.80";"4.59";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219528";"";"0";"409.53";"0";"1.77";"Table 2, r15c3";"CC(O)[C@H](NC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL220029";"";"0";"365.47";"0";"2.02";"Table 2, r7c3";"O=C(O)CNC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"17.83";"0.34";"1.76";"8.93";"True";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219597";"";"0";"403.52";"0";"2.99";"Table 1, r20c1";"O=C(CCCCCNC(=O)NC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)O";"IC50";"'='";"2700.0";"nM";"5.57";"";"";"UO_0000065";"13.80";"0.26";"2.58";"5.18";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL434374";"";"0";"256.35";"0";"2.26";"Table 1, r15c1";"O=C(O)CCCCCNC(=O)NC1CCCCC1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219595";"";"0";"384.48";"1";"0.23";"Table 1, r10c1";"N=C(N)NCCC[C@H](NC(=O)CCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"25000.0";"nM";"4.60";"";"";"UO_0000065";"11.97";"0.23";"4.37";"2.72";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL426881";"";"0";"337.38";"0";"0.15";"Table 1, r5c1";"O=C(CNC(=O)NC1CCCCC1)N[C@@H](Cc1cnc[nH]1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3353250";"";"0";"512.96";"2";"5.75";"BDBM158495";"CCN(CC)C(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"301052";"UO_0000065";"18.13";"0.36";"3.55";"11.13";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL1258785";"";"0";"443.36";"0";"4.50";"BDBM50327845";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"377041";"UO_0000065";"21.20";"0.43";"4.90";"15.30";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257169";"";"0";"408.38";"0";"3.41";"BDBM50327855";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2ccncc2)CC1";"IC50";"'='";"0.7";"nM";"9.15";"";"377044";"UO_0000065";"22.42";"0.43";"5.74";"10.96";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257285";"";"0";"422.41";"0";"3.34";"BDBM50327813";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)Cc2ccccn2)CC1";"IC50";"'='";"3.1";"nM";"8.51";"";"377046";"UO_0000065";"20.14";"0.39";"5.17";"10.18";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257404";"";"0";"471.48";"0";"1.86";"BDBM50327851";"CC(=O)N1CCN(CC(=O)N2CCC(NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"377048";"UO_0000065";"19.73";"0.38";"7.44";"9.87";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4091164";"";"0";"282.39";"0";"3.50";"42";"CC(C)(C)c1ccc(C(=O)NCc2ccc(N)cc2)cc1";"IC50";"'='";"3500.0";"nM";"5.46";"";"";"UO_0000065";"19.32";"0.35";"1.96";"9.90";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4064739";"";"0";"313.47";"0";"4.64";"51";"CSc1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)cc1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"22.08";"0.43";"2.28";"23.78";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL2392704";"";"0";"406.45";"0";"3.98";"16";"CNc1cc(C)cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"19.68";"0.38";"4.02";"13.97";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392697";"";"0";"464.49";"0";"2.57";"10g";"Cc1nc(N2CCOCC2)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.38";"0.37";"6.43";"10.78";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL153057";"";"0";"402.44";"0";"3.86";"L-165041";"CCCc1c(OCCCOc2ccc(OCC(=O)O)cc2)ccc(C(C)=O)c1O";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764468";"";"0";"407.43";"0";"4.77";"15b";"CCOC(=O)C(CC)Cc1cccc(C(=O)NCc2ccccc2C(F)(F)F)c1";"IC50";"'='";"27.0";"nM";"7.57";"";"";"UO_0000065";"18.58";"0.36";"2.80";"13.66";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764795";"";"0";"365.35";"0";"3.90";"17c";"CC(Cc1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1)C(=O)O";"IC50";"'='";"8000.0";"nM";"5.10";"";"";"UO_0000065";"13.95";"0.27";"1.20";"7.68";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3763278";"";"0";"455.48";"1";"5.52";"19b";"CCOC(=O)C(Cc1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1)c1ccccc1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"15.19";"0.29";"1.40";"12.49";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL1933656";"";"0";"511.40";"1";"4.71";"14-39";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2cc(C(F)(F)F)ccc2Br)CC1";"IC50";"'='";"17.0";"nM";"7.77";"";"";"UO_0000065";"15.19";"0.35";"3.06";"11.69";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL559228";"";"0";"423.44";"0";"4.45";"12j";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)Nc1cccc(C(F)(F)F)c1";"IC50";"'='";"13.8";"nM";"7.86";"";"";"UO_0000065";"18.56";"0.36";"3.41";"12.51";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL551597";"";"0";"391.42";"0";"3.71";"13e";"O=C(Nc1ccc(F)cc1)Nc1ccc(F)c(OCCCN2CCOCC2)c1";"IC50";"'='";"40.0";"nM";"7.40";"";"";"UO_0000065";"18.90";"0.36";"3.69";"11.77";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL551521";"";"0";"439.43";"0";"4.33";"19k";"O=C(Nc1ccc(OCCCN2CCOCC2)cc1)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"20.70";"0.40";"4.77";"12.62";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL557038";"";"0";"422.45";"0";"3.99";"20i";"O=C(Cc1ccc(C(F)(F)F)cc1)Nc1ccc(OCCCN2CCOCC2)cc1";"IC50";"'='";"54.0";"nM";"7.27";"";"";"UO_0000065";"17.20";"0.33";"3.28";"14.31";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL557240";"";"0";"438.45";"0";"3.87";"20k";"O=C(Cc1ccc(OC(F)(F)F)cc1)Nc1ccc(OCCCN2CCOCC2)cc1";"IC50";"'='";"42.0";"nM";"7.38";"";"";"UO_0000065";"16.82";"0.32";"3.51";"12.29";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1933665";"";"0";"439.43";"0";"4.29";"14-48";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2cc(Cl)c(Cl)s2)CC1";"IC50";"'='";"4200.0";"nM";"5.38";"";"";"UO_0000065";"12.24";"0.28";"1.09";"8.09";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1766287";"";"0";"543.57";"1";"4.96";"21i";"NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3ccc(C(F)(F)F)cc3)cc2-c2ccccc2)cc1";"IC50";"'='";"0.9";"nM";"9.05";"";"";"UO_0000065";"16.64";"0.33";"4.09";"7.59";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL565629";"";"0";"414.33";"0";"3.21";"2";"O=C(NC1CCOCC1)C1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"'='";"180.0";"nM";"6.75";"";"";"UO_0000065";"16.28";"0.34";"3.53";"9.54";"True";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2313181";"";"0";"423.54";"0";"3.89";"7-43";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3cnc4ccccc4c3)CC2)c(C)c1";"IC50";"'='";"2.3";"nM";"8.64";"";"";"UO_0000065";"20.40";"0.39";"4.75";"10.88";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313195";"";"0";"456.49";"0";"4.24";"7-12";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)c(C)c1";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"16.73";"0.34";"3.40";"10.09";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL512005";"";"0";"512.28";"1";"4.53";"6-6";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccc(Br)s2)CC1";"Inhibition";"'='";"43.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512131";"";"0";"433.40";"0";"3.98";"6-14";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)C2CCCCC2)CC1";"Inhibition";"'='";"27.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472076";"";"0";"512.85";"1";"4.91";"6-17";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2cccc3c(Cl)nccc23)CC1";"Inhibition";"'='";"30.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472285";"";"0";"397.33";"0";"4.22";"6-34";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(C(=O)c2cccs2)CC1";"Inhibition";"'='";"16.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471241";"";"0";"380.55";"0";"3.17";"8-1";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCCC(C)C)CC2)c(C)c1";"Inhibition";"'='";"87.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078628";"";"0";"442.00";"1";"5.55";"2n";"CCN(CC)C(=O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"19.28";"0.38";"2.97";"16.19";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL592741";"";"0";"457.38";"0";"4.15";"43";"CS(=O)(=O)c1cccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c1";"IC50";"'='";"4.6";"nM";"8.34";"";"";"UO_0000065";"18.23";"0.39";"4.19";"11.01";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL589620";"";"0";"404.30";"0";"4.62";"40";"N#Cc1cccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c1";"EC50";"'='";"0.63";"nM";"9.20";"";"";"UO_0000065";"22.76";"0.47";"4.58";"14.08";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL482637";"";"0";"454.59";"0";"3.91";"ent-1i";"CS(=O)(=O)c1ccc2c(c1)CCC1(CCCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"17.51";"0.34";"4.05";"10.51";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL511123";"";"0";"486.38";"0";"3.93";"6-21";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c([N+](=O)[O-])c1";"Inhibition";"'='";"28.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469554";"";"0";"393.34";"0";"3.06";"6-15";"CC(C)S(=O)(=O)N1CCC(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"Inhibition";"'='";"13.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512704";"";"0";"504.70";"2";"5.35";"8-3";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCCC(c3ccccc3)c3ccccc3)CC2)c(C)c1";"Inhibition";"'='";"78.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL556716";"";"0";"436.51";"0";"4.05";"24";"CS(=O)(=O)c1ccc(C(CCNC(=O)c2ccc(C#N)cc2)c2ccc(F)cc2)cc1";"EC50";"'='";"0.3";"nM";"9.52";"";"";"UO_0000065";"21.82";"0.42";"5.47";"10.94";"False";"CHEMBL1058193";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL66498";"";"0";"326.87";"0";"4.57";"17";"CCCCCCC(O)CCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"3100.0";"nM";"5.51";"";"";"UO_0000065";"16.85";"0.34";"0.94";"8.98";"True";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL69663";"";"0";"334.55";"1";"5.40";"21";"CCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"20.92";"0.40";"1.60";"17.02";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL432525";"";"0";"294.40";"0";"2.21";"23";"COC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1600.0";"nM";"5.80";"";"";"UO_0000065";"19.69";"0.38";"3.59";"8.60";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL567314";"";"0";"383.76";"0";"3.87";"40";"N#Cc1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"20.47";"0.41";"3.98";"10.47";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL585010";"";"0";"279.22";"0";"3.99";"7j";"FC(F)(F)c1ccc(Nc2noc3ccncc23)cc1";"IC50";"'='";"340.0";"nM";"6.47";"";"";"UO_0000065";"23.17";"0.44";"2.48";"12.70";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL565950";"";"0";"286.33";"1";"5.24";"7q";"c1ccc(-c2cccc(Nc3noc4ccccc34)c2)cc1";"IC50";"'='";"960.0";"nM";"6.02";"";"";"UO_0000065";"21.02";"0.37";"0.78";"15.81";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL565960";"";"0";"260.30";"0";"4.72";"7s";"c1ccc2c(Nc3noc4ccccc34)cccc2c1";"IC50";"'='";"840.0";"nM";"6.08";"";"";"UO_0000065";"23.34";"0.41";"1.36";"15.96";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL478322";"";"0";"466.63";"0";"3.71";"17";"O=C(Nc1cccc(C(=O)N2CCC(N3CCOCC3)CC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"29.0";"nM";"7.54";"";"";"UO_0000065";"16.15";"0.30";"3.83";"10.20";"True";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470605";"";"0";"506.25";"1";"4.47";"6-20";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL476668";"";"0";"328.41";"0";"3.56";"12";"COC(=O)c1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"23.91";"0.45";"4.29";"11.65";"True";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472425";"";"0";"461.58";"0";"4.40";"8-17";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3nc4ccc(F)cc4s3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469360";"";"0";"502.99";"2";"5.00";"8-33";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3cc(C(F)(F)F)ccc3Cl)CC2)c(C)c1";"IC50";"'='";"28.7";"nM";"7.54";"";"";"UO_0000065";"14.99";"0.31";"2.54";"11.34";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL397197";"";"0";"266.38";"0";"2.03";"38";"O=C(NCCCCO)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"153.0";"nM";"6.82";"";"";"UO_0000065";"25.58";"0.49";"4.79";"11.11";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL395714";"";"0";"292.42";"0";"2.56";"2";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](O)CC1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"26.86";"0.51";"5.29";"12.80";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL388015";"";"0";"380.46";"1";"5.71";"31";"O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.7";"nM";"8.57";"";"";"UO_0000065";"22.52";"0.42";"2.86";"17.01";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL243302";"";"0";"385.52";"1";"5.24";"23";"O=C(CC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"9.1";"nM";"8.04";"";"";"UO_0000065";"20.86";"0.39";"2.80";"20.98";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL374322";"";"0";"386.51";"0";"4.78";"16d";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"23.29";"0.44";"4.22";"17.87";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL243335";"";"0";"386.51";"0";"4.78";"13d";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"23.54";"0.44";"4.32";"18.06";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL67521";"";"0";"442.56";"0";"3.75";"28";"CCOC(=O)Cc1ccc(OC(=O)CCCNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"140.0";"nM";"6.85";"";"";"UO_0000065";"15.49";"0.29";"3.10";"7.31";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL1088563";"";"0";"377.80";"0";"3.60";"6f,para isomer";"O=C(Nc1ccc(Cl)cc1)Nc1ccc(C(=O)N2CCOCC2)c(F)c1";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"21.07";"0.42";"4.36";"11.26";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL456836";"";"0";"423.44";"0";"4.45";"5c";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"21.07";"0.41";"4.47";"14.20";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL457032";"";"0";"439.43";"0";"4.33";"5d";"O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"8.2";"nM";"8.09";"";"";"UO_0000065";"18.40";"0.36";"3.76";"11.22";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL454959";"";"0";"360.50";"0";"3.70";"6d";"O=C(CC1CCCCC1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"28.0";"nM";"7.55";"";"";"UO_0000065";"20.95";"0.40";"3.85";"14.87";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL302505";"";"0";"350.50";"0";"3.77";"19";"CCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"170.0";"nM";"6.77";"";"";"UO_0000065";"19.31";"0.37";"3.00";"10.04";"True";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL564975";"";"0";"311.39";"0";"2.18";"1a";"O=C(NC1CC1c1ccccc1)N1CCC(n2ccnn2)CC1";"IC50";"'='";"3619.0";"nM";"5.44";"";"";"UO_0000065";"17.47";"0.32";"3.26";"8.63";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL1933495";"";"0";"328.48";"0";"2.03";"14-4";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)C2CC2)CC1";"IC50";"'='";"450.0";"nM";"6.35";"";"";"UO_0000065";"19.32";"0.39";"4.32";"9.55";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL469547";"";"0";"441.38";"0";"4.02";"6-1";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471649";"";"0";"557.30";"2";"5.02";"6-10";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2cccc3cncc(Br)c23)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL513769";"";"0";"445.34";"0";"3.85";"6-11";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccccc2F)CC1";"IC50";"'='";"87.6";"nM";"7.06";"";"";"UO_0000065";"15.85";"0.34";"3.21";"10.62";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1095470";"";"0";"402.88";"0";"3.05";"5q, meta isomer";"O=C(Nc1ccc(Cl)cc1)Nc1cccc(C(=O)NCCN2CCOCC2)c1";"IC50";"'='";"130.0";"nM";"6.89";"";"";"UO_0000065";"17.09";"0.34";"3.84";"8.33";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1095471";"";"0";"436.43";"0";"3.41";"5r, meta isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(C(=O)NCCN2CCOCC2)c1";"IC50";"'='";"22.0";"nM";"7.66";"";"";"UO_0000065";"17.55";"0.34";"4.25";"9.26";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087863";"";"0";"325.37";"0";"2.80";"5v,para isomer";"O=C(Nc1ccccc1)Nc1ccc(C(=O)N2CCOCC2)cc1";"IC50";"'='";"251.0";"nM";"6.60";"";"";"UO_0000065";"20.29";"0.38";"3.80";"9.34";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088420";"";"0";"454.42";"0";"3.55";"6e,para isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(C(=O)NCCN2CCOCC2)c(F)c1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"19.14";"0.37";"5.15";"10.52";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1933508";"";"0";"405.52";"0";"2.89";"14-18";"O=C=Nc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"150.0";"nM";"6.82";"";"";"UO_0000065";"16.83";"0.33";"3.93";"7.11";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933661";"";"0";"434.65";"0";"4.47";"14-44";"Cc1c(C)c(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c(C)c1C";"IC50";"'='";"9.6";"nM";"8.02";"";"";"UO_0000065";"18.45";"0.37";"3.55";"12.06";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL592739";"";"0";"379.29";"0";"4.19";"27";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(O)(c2ccccc2)CC1";"IC50";"'='";"27.0";"nM";"7.57";"";"";"UO_0000065";"19.95";"0.41";"3.38";"14.40";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL592025";"";"0";"393.31";"0";"4.27";"30";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(O)(Cc2ccccc2)CC1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"19.89";"0.41";"3.55";"14.88";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL589134";"";"0";"380.28";"0";"3.57";"31";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Nc2ncccn2)CC1";"IC50";"'='";"35.0";"nM";"7.46";"";"";"UO_0000065";"19.61";"0.41";"3.89";"10.63";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1672128";"";"0";"321.42";"0";"3.47";"6, diastereomeric mixture";"COc1cccc2c1CC(C(=O)N[C@H]1C[C@@H]1c1ccccc1)CC2";"IC50";"'='";"6.457";"nM";"8.19";"";"";"UO_0000065";"25.48";"0.47";"4.72";"21.37";"False";"CHEMBL1680920";"Inhibition of human soluble epoxide hydrolase in cell free system";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL606025";"";"0";"460.36";"0";"3.79";"35";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1";"IC50";"'='";"17.0";"nM";"7.77";"";"";"UO_0000065";"16.88";"0.37";"3.98";"9.90";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL592023";"";"0";"318.30";"0";"2.82";"3";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC(CO)CC1";"IC50";"'='";"46.0";"nM";"7.34";"";"";"UO_0000065";"23.05";"0.46";"4.52";"11.87";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL576449";"";"0";"324.30";"0";"3.34";"33";"O=C(NCc1ccccc1)c1ccc(OCCC(F)(F)F)nc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL591791";"";"0";"427.38";"0";"3.13";"22";"O=C(NCCN1CCCC1)C1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"'='";"220.0";"nM";"6.66";"";"";"UO_0000065";"15.58";"0.32";"3.53";"10.29";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2397148";"";"0";"438.40";"0";"4.80";"BDBM158481";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"0.9";"nM";"9.05";"";"301035";"UO_0000065";"20.63";"0.40";"4.25";"9.34";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL2397143";"";"0";"452.43";"0";"3.85";"BDBM50436441";"CNC(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"301053";"UO_0000065";"20.56";"0.40";"5.45";"9.16";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL562822";"";"0";"389.46";"0";"3.58";"entA-2d";"O=C(N[C@@H]1C[C@H]1c1ccccc1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"19.89";"0.36";"4.16";"9.20";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL390796";"";"0";"526.81";"2";"7.67";"12";"O=C(NCCCCCCCCCCCC(=O)OC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"230.0";"nM";"6.64";"";"";"UO_0000065";"12.60";"0.24";"-1.03";"9.84";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224448";"";"0";"448.69";"1";"6.35";"10";"CC(C)COC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"15.60";"0.30";"0.65";"10.38";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL390293";"";"0";"469.69";"0";"4.23";"18";"CS(=O)(=O)NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.1";"nM";"8.68";"";"";"UO_0000065";"18.48";"0.37";"4.45";"8.31";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL438983";"";"0";"386.42";"0";"4.12";"7";"COC(=O)c1ccc(NC(=O)N[C@H]2CC[C@@H](Oc3ccc(F)cc3)CC2)cc1";"IC50";"'='";"2.9";"nM";"8.54";"";"";"UO_0000065";"22.09";"0.42";"4.42";"11.14";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL221446";"";"0";"356.44";"0";"4.95";"1{38}";"Cc1cccc(C)c1NC(=O)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"16.61";"0.31";"0.97";"11.76";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL221014";"";"0";"412.38";"1";"5.24";"1{15}";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"0.9";"nM";"9.05";"";"";"UO_0000065";"21.94";"0.43";"3.81";"15.18";"True";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL376647";"";"0";"418.53";"1";"5.06";"2{1}";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2c(F)cccc2F)CC1";"Inhibition";"'='";"75.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1257515";"";"0";"315.42";"0";"2.24";"trans-6";"CCC(=O)N1CCC(NC(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1";"IC50";"'='";"2.7";"nM";"8.57";"";"";"UO_0000065";"27.17";"0.51";"6.33";"13.95";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL213611";"";"0";"319.49";"0";"2.99";"4a";"CCN1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"3900.0";"nM";"5.41";"";"";"UO_0000065";"16.93";"0.32";"2.42";"12.19";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1258668";"";"0";"344.24";"0";"3.52";"34";"CCC(=O)N1CCC(NC(=O)Nc2c(Cl)cccc2Cl)CC1";"IC50";"'>'";"5000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL384075";"";"0";"419.57";"0";"2.84";"8b";"COC(=O)CCCC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"3.4";"nM";"8.47";"";"";"UO_0000065";"20.18";"0.39";"5.63";"9.65";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214644";"";"0";"439.56";"0";"3.35";"7c";"COC(=O)c1ccccc1C(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"19.95";"0.37";"5.42";"9.99";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL215069";"";"0";"396.54";"0";"3.20";"6h";"O=C(NCC1CCN(C(=O)c2ccncc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"7.3";"nM";"8.14";"";"";"UO_0000065";"20.52";"0.38";"4.94";"10.95";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214883";"";"0";"395.55";"0";"3.81";"6e";"O=C(NCC1CCN(C(=O)c2ccccc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.2";"nM";"8.49";"";"";"UO_0000065";"21.48";"0.40";"4.68";"13.83";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214127";"";"0";"387.45";"0";"3.06";"6d";"O=C(NCC1CCN(C(=O)C(F)(F)F)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"22.57";"0.44";"5.68";"14.23";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3099680";"";"0";"445.59";"1";"6.41";"1, ST-1366";"O=C(Nc1ccc(-c2csc(Nc3ccc(O)cc3)n2)cc1)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"170.0";"nM";"6.77";"";"";"UO_0000065";"15.19";"0.29";"0.36";"9.12";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL3099678";"";"0";"248.31";"0";"3.30";"w";"COC(=O)Nc1nc(-c2ccccc2)c(C)s1";"IC50";"'='";"379000.0";"nM";"";"Outside typical range";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL302505";"";"0";"350.50";"0";"3.77";"1";"CCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"170.0";"nM";"6.77";"";"";"UO_0000065";"19.31";"0.37";"3.00";"10.04";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL217942";"";"0";"412.55";"1";"6.58";"1{40}";"CC(C)c1cccc(C(C)C)c1NC(=O)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"50500.0";"nM";"4.30";"";"";"UO_0000065";"10.42";"0.20";"-2.28";"8.53";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL426555";"";"0";"412.38";"1";"5.24";"1{34}";"O=C(Nc1ccccc1OC(F)(F)F)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"2.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL220908";"";"0";"454.28";"0";"4.94";"1{12}";"O=C(Nc1ccc(I)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"76.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL221792";"";"0";"372.40";"0";"4.04";"10";"O=C(Nc1cccc(C(=O)O)c1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL221793";"";"0";"348.46";"0";"4.54";"1{4}";"O=C(NC1CCCCCC1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"87.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1632464";"";"0";"440.63";"0";"4.18";"17b";"CN1CCN(CCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"13.3";"nM";"7.88";"";"";"UO_0000065";"17.87";"0.34";"3.70";"13.86";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632457";"";"0";"454.62";"0";"3.71";"28b";"CC(=O)N1CCN(CCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"3.6";"nM";"8.44";"";"";"UO_0000065";"18.57";"0.35";"4.73";"11.42";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"21.71";"0.42";"3.28";"10.87";"True";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL390293";"";"0";"469.69";"0";"4.23";"18";"CS(=O)(=O)NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"14.90";"0.30";"2.77";"6.71";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL376597";"";"0";"561.85";"2";"7.48";"22";"CCCCCCCCC(NC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'='";"55.0";"nM";"7.26";"";"";"UO_0000065";"12.92";"0.25";"-0.22";"6.75";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL223900";"";"0";"420.64";"1";"5.72";"3";"CCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"16.64";"0.32";"1.28";"10.38";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"1";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"17.83";"0.34";"1.76";"8.93";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL1458";"1,3-DICYCLOHEXYLUREA";"0";"224.35";"0";"2.95";"DCU";"O=C(NC1CCCCC1)NC1CCCCC1";"IC50";"'='";"52.0";"nM";"7.28";"";"";"UO_0000065";"32.47";"0.62";"4.33";"17.71";"True";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL244068";"";"0";"408.58";"0";"3.64";"25";"CCOCCOCCOC1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"21.53";"0.41";"5.16";"12.78";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL244066";"";"0";"395.58";"0";"4.09";"22";"CCOCCOCCOCCCCCCC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"247.0";"nM";"6.61";"";"";"UO_0000065";"16.70";"0.32";"2.52";"11.63";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL245143";"";"0";"294.44";"0";"2.81";"9";"O=C(NCCCCCCO)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"26.90";"0.52";"5.11";"12.91";"False";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL397669";"";"0";"388.60";"1";"5.16";"3i";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCC2CCCCC2)CC1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"21.61";"0.41";"3.24";"16.68";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL1082684";"";"0";"396.37";"0";"3.13";"4, Table1";"O=C(NCc1ccccc1OC(F)(F)F)N1CCC(Oc2ncccn2)CC1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"21.19";"0.41";"5.27";"10.97";"False";"CHEMBL1118603";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1083622";"";"0";"452.51";"0";"4.53";"6, Table1";"O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)N1CCC(Oc2cnccn2)CC1";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"17.43";"0.33";"3.36";"11.71";"False";"CHEMBL1118602";"Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1085746";"";"0";"380.27";"0";"4.14";"2, Table1";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccncc2)CC1";"IC50";"'='";"9.0";"nM";"8.05";"";"";"UO_0000065";"21.16";"0.44";"3.91";"14.77";"False";"CHEMBL1118603";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1085744";"";"0";"395.38";"0";"3.73";"5, Table1";"O=C(NCc1ccccc1OC(F)(F)F)N1CCC(Oc2ccncc2)CC1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"19.86";"0.38";"4.12";"12.33";"False";"CHEMBL1118603";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL471240";"";"0";"471.37";"1";"5.37";"6-37";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(P(c2ccccc2)c2ccccc2)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469359";"";"0";"436.52";"0";"3.61";"8-31";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(F)cc3F)CC2)c(C)c1";"IC50";"'='";"32.2";"nM";"7.49";"";"";"UO_0000065";"17.16";"0.34";"3.88";"11.27";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469572";"";"0";"449.02";"0";"4.54";"8-34";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC(C)c3ccc(Cl)cc3)CC2)c(C)c1";"IC50";"'='";"29.1";"nM";"7.54";"";"";"UO_0000065";"16.78";"0.34";"3.00";"11.34";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471650";"";"0";"540.35";"1";"4.64";"6-19";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1";"Inhibition";"'='";"37.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470832";"";"0";"450.60";"1";"5.11";"8-6";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3c(C)ccc4ccccc34)CC2)c(C)c1";"Inhibition";"'='";"-16.0";"%";"";"Outside typical range";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512310";"";"0";"393.55";"0";"2.53";"8-43";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NN3CCCCC3)CC2)c(C)c1";"Inhibition";"'='";"55.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL551158";"";"0";"356.58";"0";"4.79";"5";"CCCCCNC(=S)NCCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"770.0";"nM";"6.11";"";"";"UO_0000065";"17.14";"0.35";"1.32";"9.96";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL551161";"";"0";"338.49";"0";"4.07";"9";"CCCCCNC(=O)NCCCCC#CCCCCCCC(=O)O";"IC50";"'='";"43.0";"nM";"7.37";"";"";"UO_0000065";"21.76";"0.42";"3.30";"9.39";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL551162";"";"0";"340.51";"0";"4.63";"10";"CCCCCNC(=O)NCCCCCCC/C=C\CCCC(=O)O";"IC50";"'='";"793.0";"nM";"6.10";"";"";"UO_0000065";"17.92";"0.35";"1.47";"7.78";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL559453";"";"0";"354.49";"0";"3.17";"16";"CCCCNC(=O)C(=O)NCCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"58712.0";"nM";"4.23";"";"";"UO_0000065";"11.94";"0.23";"1.06";"4.43";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL242470";"";"0";"306.45";"0";"3.21";"9h";"CO[C@H]1CC[C@@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"27.40";"0.52";"5.19";"16.68";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL3809228";"";"0";"288.44";"0";"3.89";"8d(S)";"C[C@H](NC(=O)NCCCc1ccccc1)C1CCCCC1";"IC50";"'='";"182.0";"nM";"6.74";"";"";"UO_0000065";"23.37";"0.44";"2.85";"16.39";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3809395";"";"0";"268.36";"0";"3.12";"8a";"O=C(NCCCc1ccccc1)NCc1ccccc1";"IC50";"'='";"3260.0";"nM";"5.49";"";"";"UO_0000065";"20.45";"0.37";"2.37";"13.34";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL1258785";"";"0";"443.36";"0";"4.50";"38";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"21.20";"0.43";"4.90";"15.30";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257404";"";"0";"471.48";"0";"1.86";"51";"CC(=O)N1CCN(CC(=O)N2CCC(NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"19.73";"0.38";"7.44";"9.87";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL214943";"";"0";"333.48";"0";"2.66";"2";"CCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"2.8";"nM";"8.55";"";"";"UO_0000065";"25.65";"0.49";"5.89";"13.92";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257514";"";"0";"311.47";"0";"3.05";"5";"CCCCCCCCNC(=O)NC1CCN(C(=O)CC)CC1";"IC50";"'='";"3.2";"nM";"8.49";"";"";"UO_0000065";"27.27";"0.53";"5.44";"13.83";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258784";"";"0";"343.35";"0";"3.23";"37";"CCC(=O)N1CCC(NC(=O)Nc2cccc(C(F)(F)F)c2)CC1";"IC50";"'='";"17.0";"nM";"7.77";"";"";"UO_0000065";"22.63";"0.44";"4.54";"12.65";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1256163";"";"0";"275.35";"0";"2.21";"7";"CCC(=O)N1CCC(NC(=O)Nc2ccccc2)CC1";"IC50";"'='";"130.0";"nM";"6.89";"";"";"UO_0000065";"25.01";"0.47";"4.68";"11.21";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258107";"";"0";"333.39";"0";"2.00";"21";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(=O)OC)cc2)CC1";"IC50";"'='";"140.0";"nM";"6.85";"";"";"UO_0000065";"20.56";"0.39";"4.85";"7.81";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1256165";"";"0";"276.34";"0";"1.60";"9";"CCC(=O)N1CCC(NC(=O)Nc2cccnc2)CC1";"IC50";"'='";"3800.0";"nM";"5.42";"";"";"UO_0000065";"19.61";"0.37";"3.82";"7.29";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257990";"";"0";"365.43";"0";"2.23";"18";"CCC(=O)N1CCC(NC(=O)Nc2cc(OC)c(OC)c(OC)c2)CC1";"IC50";"'>'";"5000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL514055";"";"0";"390.48";"0";"5.00";"11";"O=C(Nc1ccc(OC(=O)c2ccccc2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"20.38";"0.37";"2.96";"11.80";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL477237";"";"0";"356.47";"0";"3.88";"22";"COC(=O)CCc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"2.2";"nM";"8.66";"";"";"UO_0000065";"24.29";"0.45";"4.78";"12.84";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL477046";"";"0";"330.38";"0";"3.18";"25";"O=C(Nc1ccc(O)c(C(=O)O)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"116.0";"nM";"6.94";"";"";"UO_0000065";"20.99";"0.39";"3.76";"7.03";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472284";"";"0";"452.29";"0";"4.43";"6-33";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(C(=O)Oc2ccc([N+](=O)[O-])cc2)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469573";"";"0";"511.09";"2";"5.57";"8-35";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC(c3ccccc3)c3ccc(Cl)cc3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469998";"";"0";"452.98";"0";"4.12";"8-37";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3c(F)cccc3Cl)CC2)c(C)c1";"IC50";"'='";"12.7";"nM";"7.90";"";"";"UO_0000065";"17.43";"0.36";"3.78";"11.88";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469784";"";"0";"434.99";"0";"3.98";"8-39";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3)CC2)c(C)c1";"IC50";"'='";"50.0";"nM";"7.30";"";"";"UO_0000065";"16.78";"0.34";"3.32";"10.98";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469792";"";"0";"406.59";"0";"3.85";"8-42";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c(C)c1";"IC50";"'='";"7.9";"nM";"8.10";"";"";"UO_0000065";"19.93";"0.40";"4.25";"12.19";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1085745";"";"0";"365.36";"0";"3.68";"3, Table1";"O=C(NCc1ccccc1OC(F)(F)F)N1CCC(c2ccncc2)C1";"IC50";"'='";"76.0";"nM";"7.12";"";"";"UO_0000065";"19.49";"0.37";"3.44";"13.07";"False";"CHEMBL1118602";"Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL590600";"";"0";"353.34";"0";"4.26";"1, Figure1";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC(n2cccc2)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"22.42";"0.43";"3.66";"17.03";"False";"CHEMBL1118603";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL223956";"";"0";"430.63";"1";"5.33";"6";"C#CCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"20.31";"0.39";"3.41";"12.97";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL1079257";"";"0";"454.88";"1";"5.79";"3a";"O=C(O)CCC1(c2ccccc2C(F)(F)F)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL471860";"";"0";"490.34";"0";"3.76";"6-9";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccc(F)cc2[N+](=O)[O-])CC1";"IC50";"'='";"150.0";"nM";"6.82";"";"";"UO_0000065";"13.92";"0.30";"3.06";"6.23";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL192549";"";"0";"333.56";"1";"5.85";"17";"CCCCCCCCCCNC(=O)CC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"20.99";"0.40";"1.15";"24.05";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL192843";"";"0";"245.37";"0";"3.46";"a-3";"O=C(CCCc1ccccc1)NC1CCCCC1";"IC50";"'='";"1400.0";"nM";"5.85";"";"";"UO_0000065";"23.86";"0.44";"2.39";"20.12";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL608263";"";"0";"423.30";"0";"4.44";"47";"O=C(O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"IC50";"'='";"6.4";"nM";"8.19";"";"";"UO_0000065";"19.36";"0.40";"3.75";"10.39";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL589859";"";"0";"404.30";"0";"4.62";"41";"N#Cc1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"EC50";"'='";"0.78";"nM";"9.11";"";"";"UO_0000065";"22.53";"0.46";"4.49";"13.93";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL592743";"";"0";"436.34";"0";"4.11";"45";"CNC(=O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"EC50";"'='";"0.34";"nM";"9.47";"";"";"UO_0000065";"21.70";"0.45";"5.36";"13.40";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL524992";"";"0";"375.39";"0";"4.71";"2a";"O=C(c1ccc(C(F)(F)F)cc1)N1CCC2(CCc3ccccc3O2)CC1";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL564547";"";"0";"326.40";"0";"2.82";"1i";"Cc1noc(C2CCN(C(=O)NC3CC3c3ccccc3)CC2)n1";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL562926";"";"0";"417.51";"0";"3.97";"3b";"O=C(NC1CCc2ccccc2CC1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"181.0";"nM";"6.74";"";"";"UO_0000065";"16.15";"0.30";"2.77";"8.01";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL550242";"";"0";"403.49";"0";"3.58";"3c";"O=C(NC1CCc2ccccc2C1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"20.07";"0.37";"4.52";"9.62";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL589135";"";"0";"379.29";"0";"4.75";"32";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccccc2)CC1";"IC50";"'='";"5.1";"nM";"8.29";"";"";"UO_0000065";"21.86";"0.45";"3.54";"19.95";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL396760";"";"0";"402.54";"0";"4.21";"27";"CCOCCOCCOc1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"22.26";"0.42";"4.75";"13.02";"True";"CHEMBL896996";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148831";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL434749";"";"0";"397.28";"1";"5.64";"1{39}";"O=C(Nc1c(Cl)cccc1Cl)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"940.0";"nM";"6.03";"";"";"UO_0000065";"15.17";"0.32";"0.39";"11.97";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL426555";"";"0";"412.38";"1";"5.24";"1{34}";"O=C(Nc1ccccc1OC(F)(F)F)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"16.97";"0.33";"1.76";"11.75";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL221014";"";"0";"412.38";"1";"5.24";"1{15}";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"84.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL11524";"";"0";"254.42";"0";"3.83";"87";"CC(C)(C)CC(C)(C)NC(=O)NC1CCCCC1";"IC50";"'='";"0.49";"";"";"Non standard unit for type";"";"";"";"";"";"";"False";"CHEMBL809079";"Inhibitory activity against human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1136721";"1";"Scientific Literature";"J. Med. Chem.";"2003";"None"
"CHEMBL1088546";"";"0";"434.46";"0";"4.52";"5j,para isomer";"CC(C)N1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)cc2)CC1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"20.02";"0.38";"4.18";"13.45";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087862";"";"0";"442.95";"0";"3.92";"5u,para isomer";"O=C(Nc1ccc(Cl)cc1)Nc1ccc(C(=O)N2CCC(N3CCOCC3)CC2)cc1";"IC50";"'='";"235.0";"nM";"6.63";"";"";"UO_0000065";"14.97";"0.29";"2.71";"8.97";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1086851";"";"0";"424.40";"0";"3.88";"6a,para isomer";"CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)cc2F)CC1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"19.79";"0.38";"4.52";"12.98";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL40275";"ALOE-EMODIN";"0";"270.24";"0";"1.37";"1";"O=C1c2cccc(O)c2C(=O)c2c(O)cc(CO)cc21";"Inhibition";"'='";"79.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3620668";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde at 100 uM measured during 1 hr by fluorescence photometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL1766294";"";"0";"514.53";"2";"5.28";"11f";"CS(=O)(=O)c1ccc(-n2nc(CNC(=O)Nc3cccc(C(F)(F)F)c3)cc2-c2ccccc2)cc1";"IC50";"'='";"72.0";"nM";"7.14";"";"";"UO_0000065";"13.88";"0.27";"1.86";"7.67";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766298";"";"0";"529.54";"1";"4.57";"15";"NS(=O)(=O)c1ccc(-n2nc(CCNC(=O)Nc3cccc(C(F)(F)F)c3)cc2-c2ccccc2)cc1";"IC50";"'='";"26.0";"nM";"7.58";"";"";"UO_0000065";"14.32";"0.28";"3.02";"6.37";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL289277";"EMODIN";"0";"270.24";"0";"1.89";"6";"Cc1cc(O)c2c(c1)C(=O)c1cc(O)cc(O)c1C2=O";"Inhibition";"'='";"56.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3628770";"";"0";"504.65";"2";"6.96";"17";"CCOP(=O)(OCC)C(CC(C)(C)C)Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"41.0";"nM";"7.39";"";"";"UO_0000065";"14.64";"0.29";"0.43";"9.64";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628765";"";"0";"560.68";"2";"8.05";"12";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)c1ccc2ccccc2c1";"IC50";"'='";"186.0";"nM";"6.73";"";"";"UO_0000065";"12.00";"0.23";"-1.32";"8.78";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628416";"";"0";"511.60";"2";"6.29";"10";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)c1ccncc1";"IC50";"'='";"185.0";"nM";"6.73";"";"";"UO_0000065";"13.16";"0.26";"0.44";"7.52";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL215999";"";"0";"439.56";"0";"3.35";"7e";"COC(=O)c1ccc(C(=O)N2CCC(NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"20.38";"0.38";"5.61";"10.21";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214128";"";"0";"382.51";"0";"2.95";"5g";"O=C(NC1CCN(C(=O)c2cccnc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"22.93";"0.43";"5.82";"11.80";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL215161";"";"0";"382.51";"0";"2.95";"5f";"O=C(NC1CCN(C(=O)c2ccccn2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"23.32";"0.44";"5.97";"12.00";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL215125";"";"0";"347.50";"0";"3.05";"5c";"CCCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"2.6";"nM";"8.59";"";"";"UO_0000065";"24.71";"0.47";"5.54";"13.97";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1766299";"";"0";"543.57";"1";"4.96";"21b";"NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3cccc(C(F)(F)F)c3)cc2-c2ccccc2)cc1";"IC50";"'='";"4.1";"nM";"8.39";"";"";"UO_0000065";"15.43";"0.30";"3.43";"7.04";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL3236513";"";"0";"306.23";"0";"0.75";"23";"COC(=O)[C@H]1CC(=O)c2oc(=O)c3cc(O)c(O)c(O)c3c21";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"21.71";"0.42";"3.28";"10.87";"True";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214735";"";"0";"439.56";"0";"3.51";"8h";"O=C(NCC1CCN(C(=O)c2ccccc2C(=O)O)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"400.0";"nM";"6.40";"";"";"UO_0000065";"14.56";"0.27";"2.89";"6.48";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1957971";"";"0";"390.53";"0";"4.89";"EP6";"Cc1ccc2nc(-c3ccc(N4CCOCC4)cc3)c(NC3CCCCC3)n2c1";"IC50";"'='";"59.0";"nM";"7.23";"";"";"UO_0000065";"18.51";"0.34";"2.34";"17.29";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL192299";"";"0";"325.84";"0";"4.57";"7";"CCCCCOC(=O)CCCCC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"5900.0";"nM";"5.23";"";"";"UO_0000065";"16.05";"0.32";"0.66";"9.44";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL2392689";"";"0";"365.44";"0";"1.63";"24";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3C#N)CC2)n1";"IC50";"'='";"80.0";"nM";"7.10";"";"";"UO_0000065";"19.42";"0.36";"5.47";"6.64";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392691";"";"0";"438.45";"0";"2.78";"26";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(OC)cc3C(F)(F)F)CC2)n1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"20.53";"0.40";"6.22";"9.75";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392710";"";"0";"424.43";"0";"2.65";"22";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(OC(F)(F)F)cc3)CC2)n1";"IC50";"'='";"400.0";"nM";"6.40";"";"";"UO_0000065";"15.07";"0.29";"3.75";"6.93";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392699";"";"0";"407.44";"0";"3.38";"11";"CNc1nc(C)cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"40.0";"nM";"7.40";"";"";"UO_0000065";"18.16";"0.35";"4.02";"10.55";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3327083";"";"0";"393.43";"0";"3.03";"27";"CCCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"1.47";"nM";"8.83";"";"";"UO_0000065";"22.45";"0.46";"5.80";"11.25";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL550923";"";"0";"335.45";"0";"2.71";"12a";"CC(C)(C)NC(=O)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"1040.0";"nM";"5.98";"";"";"UO_0000065";"17.84";"0.34";"3.27";"9.52";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3402236";"";"0";"228.17";"0";"2.60";"Fragment 5";"Oc1cnn(-c2cccc(C(F)(F)F)c2)c1";"IC50";"'='";"52000.0";"nM";"4.28";"";"";"UO_0000065";"18.78";"0.37";"1.68";"11.26";"False";"CHEMBL3406221";"Inhibition of C-terminal His6-tagged full-length human soluble epoxide hydrolase expressed in Escherichia coli BL21(DE3) cells pre-incubated for 15 mins before addition of PHOME substrate and measured 50 mins after substrate addition by microplate reader based fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400124";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3402235";"";"0";"198.27";"0";"2.47";"Fragment 2";"CNCc1cccc(-c2cccnc2)c1";"IC50";"'='";"2200000.0";"nM";"2.66";"";"";"UO_0000065";"13.40";"0.24";"0.19";"10.66";"False";"CHEMBL3406221";"Inhibition of C-terminal His6-tagged full-length human soluble epoxide hydrolase expressed in Escherichia coli BL21(DE3) cells pre-incubated for 15 mins before addition of PHOME substrate and measured 50 mins after substrate addition by microplate reader based fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400124";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL1085743";"";"0";"422.48";"0";"4.48";"7, Table1";"O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)N1CCC(c2cnccn2)C1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"20.17";"0.38";"4.04";"14.66";"False";"CHEMBL1118603";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL469373";"";"0";"419.52";"0";"3.29";"8-24";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NNc3ccc(F)cc3)CC2)c(C)c1";"Inhibition";"'='";"9.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472283";"";"0";"580.58";"1";"4.87";"6-31";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)N3CCC(C(=O)NCc4ccc(Cl)cc4Cl)CC3)CC2)c(C)c1";"Inhibition";"'='";"33.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471452";"";"0";"444.60";"0";"3.38";"8-26";"COc1ccc(CCNC(=O)C2CCN(S(=O)(=O)c3c(C)cc(C)cc3C)CC2)cc1";"Inhibition";"'='";"44.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3322801";"";"0";"499.56";"0";"3.59";"6";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)N[C@@H](CC(=O)[O-])C(=O)[O-].[Na+].[Na+]";"IC50";"'='";"392.0";"nM";"6.41";"";"";"UO_0000065";"14.06";"0.27";"2.82";"4.42";"False";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322816";"";"0";"378.52";"0";"2.45";"21";"CCCCNC(=O)C(=O)NCCCC/C=C\CCCCCCc1nnn[nH]1";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"21.71";"0.42";"3.28";"10.87";"False";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327071";"";"0";"345.49";"0";"3.97";"11";"CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(C)C)cc2)CC1";"T1/2";"'='";"0.3333";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3401635";"";"0";"520.58";"2";"5.48";"15";"O=C(O)CCc1ccc(OC2CCN(C(=O)N[C@H]3[C@H](c4ccc(F)cc4)[C@@H]3c3ccc(F)cc3)CC2)cc1";"IC50";"'='";"2.1";"nM";"8.68";"";"";"UO_0000065";"16.67";"0.31";"3.20";"11.00";"False";"CHEMBL3406976";"Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400076";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3401630";"";"0";"408.50";"0";"3.81";"1";"O=C(O)CCc1ccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)cc1";"IC50";"'='";"19.1";"nM";"7.72";"";"";"UO_0000065";"18.90";"0.35";"3.91";"9.79";"False";"CHEMBL3406976";"Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400076";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL556234";"";"0";"510.51";"1";"4.52";"23";"CS(=O)(=O)c1ccc(C(CCNC(=O)c2ccc(OCC(F)(F)F)nc2)c2ccc(F)cc2)cc1";"EC50";"'='";"0.3";"nM";"9.52";"";"";"UO_0000065";"18.65";"0.37";"5.00";"11.16";"False";"CHEMBL1058193";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL562081";"";"0";"489.59";"0";"3.58";"25";"CS(=O)(=O)c1ccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(S(C)(=O)=O)cc2)cc1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"16.66";"0.34";"4.57";"8.37";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL563416";"";"0";"352.46";"0";"3.58";"7";"O=S(=O)(NCCC(c1ccccc1)c1ccccc1)c1cccnc1";"IC50";"'>'";"3000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL2031923";"";"0";"312.46";"0";"3.89";"58";"O=C(NCCCc1ccccc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"28.80";"0.53";"5.11";"21.88";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031926";"";"0";"362.56";"0";"4.77";"67";"CCCCCO[C@H]1CC[C@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"24.61";"0.47";"4.15";"17.71";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL243125";"";"0";"447.42";"1";"5.41";"113";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(Br)cc2)CC1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"20.02";"0.44";"3.55";"17.79";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL472283";"";"0";"580.58";"1";"4.87";"6-31";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)N3CCC(C(=O)NCc4ccc(Cl)cc4Cl)CC3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL511291";"";"0";"444.64";"0";"4.10";"8-5";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c(C)c1";"Inhibition";"'='";"-1.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL511448";"";"0";"401.53";"0";"3.16";"8-22";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NNc3ccccc3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471450";"";"0";"450.60";"0";"4.48";"8-2";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3cccc4ccccc34)CC2)c(C)c1";"Inhibition";"'='";"55.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470616";"";"0";"434.99";"0";"3.98";"8-28";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccccc3Cl)CC2)c(C)c1";"Inhibition";"'='";"90.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469372";"";"0";"393.55";"0";"1.88";"8-50";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCNCC3)CC2)c(C)c1";"Inhibition";"'='";"15.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470834";"";"0";"386.52";"0";"3.65";"8-8";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469361";"";"0";"469.43";"0";"4.64";"8-30";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3cc(Cl)ccc3Cl)CC2)c(C)c1";"IC50";"'='";"59.1";"nM";"7.23";"";"";"UO_0000065";"15.40";"0.33";"2.59";"10.87";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472423";"";"0";"483.46";"0";"4.94";"8-38";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3c(C)cc(Cl)cc3Cl)CC2)c(C)c1";"IC50";"'='";"128.0";"nM";"6.89";"";"";"UO_0000065";"14.26";"0.30";"1.95";"10.37";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL477670";"";"0";"286.38";"0";"3.48";"2";"O=C(Nc1ccccc1O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"139.0";"nM";"6.86";"";"";"UO_0000065";"23.94";"0.45";"3.38";"11.18";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL459984";"";"0";"429.63";"0";"4.04";"8";"S=C(Nc1cccc(OCCCN2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"22.0";"nM";"7.66";"";"";"UO_0000065";"17.82";"0.35";"3.62";"16.73";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL517114";"";"0";"427.59";"0";"3.28";"11";"O=C(CNC12CC3CC(CC(C3)C1)C2)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"16.27";"0.31";"3.68";"11.08";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471427";"";"0";"405.54";"1";"5.17";"19b";"O=C(Nc1ccc(OCc2ccccc2)cc1)C(O)CC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"270.0";"nM";"6.57";"";"";"UO_0000065";"16.20";"0.30";"1.40";"11.22";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL242899";"";"0";"461.44";"1";"5.54";"126";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2ccc(Br)cc2)CC1";"IC50";"'='";"12.3";"nM";"7.91";"";"";"UO_0000065";"17.14";"0.37";"2.37";"15.71";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2032040";"";"0";"389.54";"0";"2.67";"132";"O=C(NC1CCCC(C(=O)N2CCOCC2)C1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"8.2";"nM";"8.09";"";"";"UO_0000065";"20.76";"0.39";"5.42";"11.44";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL496189";"";"0";"376.46";"0";"3.75";"rac-1a";"O=C1CC2(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)Oc2ccccc21";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"22.64";"0.42";"4.77";"14.53";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1632489";"";"0";"526.72";"2";"5.49";"21a";"CC(C)(C)OC(=O)N1CCN(CCCCOc2ccccc2NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"16.5";"nM";"7.78";"";"";"UO_0000065";"14.78";"0.28";"2.29";"9.36";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1078657";"";"0";"414.93";"1";"5.55";"2d";"O=C(O)CCCCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1078755";"";"0";"367.88";"1";"5.21";"2f";"N#CCCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"23.17";"0.45";"3.31";"15.18";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1079140";"";"0";"385.94";"0";"4.86";"2j";"CN(C)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"20.52";"0.40";"3.06";"22.26";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL584810";"";"0";"235.29";"0";"3.24";"7g";"c1ccc(CNc2cnc3ccccc3n2)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1766302";"";"0";"559.74";"2";"6.19";"21d";"CC(C)c1cccc(C(C)C)c1NC(=O)NCCCc1cc(-c2ccccc2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"IC50";"'='";"1550.0";"nM";"5.81";"";"";"UO_0000065";"10.38";"0.20";"-0.38";"4.88";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766285";"";"0";"495.65";"0";"4.14";"21g";"NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)NC3CCCCCC3)cc2-c2ccccc2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"18.77";"0.36";"5.16";"7.81";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL2392711";"";"0";"492.55";"0";"2.22";"4";"CNc1nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)nc(N2CCN(C)CC2)n1";"IC50";"'='";"40.0";"nM";"7.40";"";"";"UO_0000065";"15.02";"0.29";"5.18";"8.26";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392713";"";"0";"494.57";"0";"2.46";"8b";"CNc1nc(N(C)CCN(C)C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"80.0";"nM";"7.10";"";"";"UO_0000065";"14.35";"0.28";"4.64";"7.93";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL551338";"";"0";"429.49";"0";"4.32";"16";"CS(=O)(=O)c1ccc(C(=O)NCCC(c2ccc(F)cc2)c2ccc(F)cc2)cc1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"19.33";"0.38";"3.98";"13.13";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL569141";"";"0";"316.40";"0";"4.03";"8";"O=C(NCCC(c1ccccc1)c1ccccc1)c1ccccn1";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"22.12";"0.40";"2.97";"16.67";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL2070330";"";"0";"396.53";"0";"2.63";"8";"CCOCCOCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"67.0";"nM";"7.17";"";"";"UO_0000065";"18.09";"0.35";"4.54";"8.35";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL302505";"";"0";"350.50";"0";"3.77";"4";"CCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"22.82";"0.44";"4.23";"11.86";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL2070329";"";"0";"375.51";"0";"3.66";"7";"CCCCC(C#N)OC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"21.09";"0.40";"4.26";"8.68";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL2031928";"";"0";"266.77";"0";"4.04";"70";"O=C(NCC1CCCCC1)Nc1cccc(Cl)c1";"IC50";"'='";"2.6";"nM";"8.59";"";"";"UO_0000065";"32.18";"0.65";"4.55";"20.87";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031936";"";"0";"348.25";"1";"5.37";"93";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"22.47";"0.45";"2.45";"19.02";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031796";"";"0";"472.63";"0";"4.37";"101";"CCOCCOCC(OC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2)c1ccccc1";"IC50";"'='";"4.2";"nM";"8.38";"";"";"UO_0000065";"17.72";"0.34";"4.01";"9.75";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031808";"";"0";"372.47";"0";"3.72";"21";"CCOC(=O)COc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"24.42";"0.46";"5.38";"11.87";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL387810";"";"0";"360.47";"0";"4.25";"57, 98";"O=C(NCCCCOc1ccc(F)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"11.1";"nM";"7.96";"";"";"UO_0000065";"22.07";"0.42";"3.70";"15.80";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL220028";"";"0";"437.54";"0";"2.25";"Table 2, r6c3";"O=C(O)CC[C@H](NC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219141";"";"0";"464.61";"1";"1.65";"Table 2, r4c3";"N=C(N)NCCC[C@H](NC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219095";"";"0";"322.45";"0";"2.99";"Table 2, r2c3";"COC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1800.0";"nM";"5.75";"";"";"UO_0000065";"17.82";"0.34";"2.75";"8.52";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219026";"";"0";"327.43";"0";"1.62";"Table 1, r14c1";"CC(C)[C@H](NC(=O)CCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"17000.0";"nM";"4.77";"";"";"UO_0000065";"14.57";"0.28";"3.15";"4.44";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1258106";"";"0";"320.35";"0";"2.12";"BDBM50327827";"CCC(=O)N1CCC(NC(=O)Nc2ccc([N+](=O)[O-])cc2)CC1";"IC50";"'='";"38.0";"nM";"7.42";"";"377023";"UO_0000065";"23.16";"0.44";"5.30";"7.10";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322814";"";"0";"364.54";"0";"3.91";"BDBM50057494";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1nnn[nH]1";"IC50";"'='";"11.0";"nM";"7.96";"";"326393";"UO_0000065";"21.83";"0.42";"4.05";"8.33";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3938484";"";"0";"349.48";"0";"3.29";"BDBM181776";"O=C(NCCCc1ccccc1)N1CC2(CCN2Cc2ccccc2)C1";"IC50";"'='";"1980.0";"nM";"5.70";"";"328783";"UO_0000065";"16.32";"0.30";"2.41";"16.03";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL593661";"";"0";"262.35";"0";"1.91";"12";"Cc1ccccc1CNC(=O)N1CCCC(CO)C1";"IC50";"'='";"1500.0";"nM";"5.82";"";"";"UO_0000065";"22.20";"0.42";"3.91";"11.08";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL69495";"";"0";"328.80";"0";"3.80";"12";"CCCCCOC(=O)OCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'='";"22000.0";"nM";"4.66";"";"";"UO_0000065";"14.17";"0.29";"0.86";"6.08";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL2313180";"";"0";"422.55";"0";"4.50";"7-42";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc4ccccc4c3)CC2)c(C)c1";"IC50";"'='";"8.3";"nM";"8.08";"";"";"UO_0000065";"19.12";"0.37";"3.58";"12.16";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313176";"";"0";"504.55";"1";"3.64";"7-38";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(S(=O)(=O)C(F)(F)F)cc3)CC2)c(C)c1";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"17.43";"0.36";"5.16";"8.74";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313174";"";"0";"498.65";"0";"3.43";"7-36";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(N4CCCCC4)c(C(N)=O)c3)CC2)c(C)c1";"IC50";"'='";"43.0";"nM";"7.37";"";"";"UO_0000065";"14.77";"0.29";"3.94";"6.53";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313165";"";"0";"426.58";"0";"3.90";"7-27";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCc4ccccc43)CC2)c(C)c1";"IC50";"'='";"41.0";"nM";"7.39";"";"";"UO_0000065";"17.32";"0.34";"3.49";"11.11";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313161";"";"0";"416.50";"0";"3.07";"7-23";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc4c(c3)OCO4)CC2)c(C)c1";"IC50";"'='";"5.2";"nM";"8.28";"";"";"UO_0000065";"19.89";"0.39";"5.21";"9.75";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313203";"";"0";"423.54";"0";"3.89";"7-20";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3cccc4cccnc34)CC2)c(C)c1";"IC50";"'='";"6.0";"nM";"8.22";"";"";"UO_0000065";"19.41";"0.37";"4.33";"10.36";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1818418";"";"0";"280.41";"0";"2.68";"39";"CC(C)OCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"260.4";"nM";"6.58";"";"";"UO_0000065";"23.48";"0.45";"3.90";"13.07";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL386855";"";"0";"396.54";"0";"3.20";"6f";"O=C(NCC1CCN(C(=O)c2ccccn2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"7.6";"nM";"8.12";"";"";"UO_0000065";"20.48";"0.38";"4.92";"10.92";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214179";"";"0";"382.51";"0";"2.95";"5h";"O=C(NC1CCN(C(=O)c2ccncc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.1";"nM";"8.68";"";"";"UO_0000065";"22.69";"0.42";"5.73";"11.67";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL191967";"";"0";"251.76";"0";"3.33";"b-3";"O=C(Cc1cccc(Cl)c1)NC1CCCCC1";"IC50";"'='";"38000.0";"nM";"4.42";"";"";"UO_0000065";"17.56";"0.36";"1.09";"15.19";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL191968";"";"0";"248.33";"0";"3.15";"c-1";"COc1ccc(NC(=O)NC2CCCCC2)cc1";"IC50";"'='";"230.0";"nM";"6.64";"";"";"UO_0000065";"26.73";"0.50";"3.49";"13.18";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL219151";"";"0";"421.58";"0";"3.43";"Table 2, r10c3";"CC(C)C[C@H](NC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL375839";"";"0";"423.51";"0";"1.86";"Table 2, r5c3";"O=C(O)C[C@H](NC(=O)CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL195796";"";"0";"350.55";"0";"4.37";"2";"CCCCCCC(O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"130.0";"nM";"6.89";"";"";"UO_0000065";"19.64";"0.38";"2.52";"11.22";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL192048";"";"0";"325.84";"0";"3.51";"8";"CCCCCOC(=O)CCCNC(=O)Cc1cccc(Cl)c1";"IC50";"'='";"5000.0";"nM";"5.30";"";"";"UO_0000065";"16.27";"0.33";"1.79";"9.57";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL2392700";"";"0";"407.44";"0";"3.38";"12";"CNc1cc(C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"160.0";"nM";"6.80";"";"";"UO_0000065";"16.68";"0.32";"3.42";"9.69";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL304297";"";"0";"214.26";"0";"1.09";"3";"O=C(O)CCNC(=O)NC1CCCCC1";"IC50";"'='";"358000.0";"nM";"";"Outside typical range";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL2392723";"";"0";"327.45";"0";"4.39";"35";"O=C(Nc1nc2ccccc2s1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"26.03";"0.51";"4.13";"15.78";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392719";"";"0";"289.38";"0";"3.38";"31";"Cc1noc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1C";"IC50";"'='";"20.0";"nM";"7.70";"";"";"UO_0000065";"26.61";"0.50";"4.32";"11.46";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392754";"";"0";"261.32";"0";"2.76";"21";"O=C(Nc1ncco1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"948.0";"nM";"6.02";"";"";"UO_0000065";"23.05";"0.43";"3.26";"8.97";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL1766291";"";"0";"446.53";"0";"4.26";"11c";"CS(=O)(=O)c1ccc(-n2nc(CNC(=O)Nc3ccccc3)cc2-c2ccccc2)cc1";"IC50";"'='";"47.0";"nM";"7.33";"";"";"UO_0000065";"16.41";"0.31";"3.07";"7.87";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1766288";"";"0";"559.57";"1";"4.84";"21j";"NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccccc2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"16.62";"0.33";"4.46";"7.25";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL68172";"";"0";"442.56";"0";"3.95";"27";"CCOC(=O)c1ccc(COC(=O)CCCNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"15.82";"0.30";"3.05";"7.47";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL560537";"";"0";"316.40";"0";"4.03";"1";"O=C(NCCC(c1ccccc1)c1ccccc1)c1cccnc1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"25.77";"0.46";"4.12";"19.42";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3127882";"";"0";"426.56";"0";"3.00";"1";"O=C(NC1C2CC3CC1CC(O)(C3)C2)c1cnc(N[C@H]2CCOC2)nc1C1CCCC1";"IC50";"'='";"22.0";"nM";"7.66";"";"";"UO_0000065";"17.95";"0.34";"4.66";"7.95";"False";"CHEMBL3130369";"Inhibition of sEH (unknown origin)";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3124933";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1088687";"";"0";"409.36";"0";"3.94";"5c, meta isomer";"O=C(O)CCCNC(=O)c1cccc(NC(=O)Nc2ccc(C(F)(F)F)cc2)c1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"16.91";"0.33";"2.98";"6.44";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL3628767";"";"0";"516.66";"2";"7.10";"14";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C1CCCCC1";"IC50";"'='";"46.0";"nM";"7.34";"";"";"UO_0000065";"14.20";"0.28";"0.24";"9.57";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3104432";"";"0";"494.47";"0";"3.99";"29";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3cnoc3C3CC3)CC2)C1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"18.65";"0.36";"5.23";"9.49";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL2392724";"";"0";"276.34";"0";"2.47";"36";"Cc1nnc(NC(=O)NC23CC4CC(CC(C4)C2)C3)o1";"IC50";"'='";"595.0";"nM";"6.22";"";"";"UO_0000065";"22.53";"0.43";"3.76";"7.78";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392757";"";"0";"317.43";"0";"4.06";"24";"CC(C)(C)c1cc(NC(=O)NC23CC4CC(CC(C4)C2)C3)no1";"IC50";"'='";"56.0";"nM";"7.25";"";"";"UO_0000065";"22.85";"0.43";"3.19";"10.80";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392756";"";"0";"275.35";"0";"3.07";"23";"Cc1cc(NC(=O)NC23CC4CC(CC(C4)C2)C3)no1";"IC50";"'='";"136.0";"nM";"6.87";"";"";"UO_0000065";"24.94";"0.47";"3.80";"10.22";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL511137";"";"0";"426.58";"0";"3.30";"8-27";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3Cc4ccccc4C3)CC2)c(C)c1";"Inhibition";"'='";"62.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470614";"";"0";"449.02";"0";"4.02";"8-29";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCCc3cccc(Cl)c3)CC2)c(C)c1";"Inhibition";"'='";"65.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472628";"";"0";"471.02";"1";"5.46";"8-11";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3ccc(Cl)c4ccccc34)CC2)c(C)c1";"Inhibition";"'='";"44.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472425";"";"0";"461.58";"0";"4.40";"8-17";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3nc4ccc(F)cc4s3)CC2)c(C)c1";"Inhibition";"'='";"-6.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3327064";"";"0";"357.38";"0";"3.47";"4";"CC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"T1/2";"'='";"0.2933";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327077";"";"0";"373.38";"0";"3.35";"19";"CC(C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"Ki";"'='";"0.31";"nM";"9.51";"";"";"UO_0000065";"25.47";"0.50";"6.16";"13.45";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327064";"";"0";"357.38";"0";"3.47";"4";"CC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"0.66";"nM";"9.18";"";"";"UO_0000065";"25.69";"0.50";"5.71";"14.94";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL568770";"";"0";"297.14";"0";"2.61";"6";"O=C(NCc1ccc(Cl)cc1Cl)c1ccc(=O)[nH]c1";"IC50";"'='";"400.0";"nM";"6.40";"";"";"UO_0000065";"21.53";"0.46";"3.79";"10.33";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1080076";"";"0";"370.50";"1";"5.94";"1d";"CC1(c2ccccc2)CCCN(C(=O)Nc2ccc(-c3ccccc3)cc2)C1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"22.01";"0.40";"2.21";"25.22";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078336";"";"0";"387.87";"0";"4.17";"3d";"O=C(O)CCC1(c2ccncc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"30.0";"nM";"7.52";"";"";"UO_0000065";"19.40";"0.38";"3.35";"9.12";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1615216";"";"0";"354.45";"0";"3.64";"11";"CC(C)c1noc(C2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)n1";"IC50";"'='";"8.5";"nM";"8.07";"";"";"UO_0000065";"22.77";"0.42";"4.43";"11.33";"False";"CHEMBL1680920";"Inhibition of human soluble epoxide hydrolase in cell free system";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL302664";"";"0";"326.83";"0";"2.95";"16";"CCCCCNC(=O)NCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL3263299";"";"0";"462.64";"1";"5.87";"4a";"O=C(Nc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"19.5";"nM";"7.71";"";"";"UO_0000065";"16.67";"0.31";"1.84";"9.37";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL215168";"";"0";"319.49";"0";"3.13";"3b";"CCCN1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"810.0";"nM";"6.09";"";"";"UO_0000065";"19.07";"0.36";"2.96";"13.73";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL2031807";"";"0";"312.41";"0";"3.98";"20";"CC(=O)c1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"28.44";"0.53";"4.91";"15.27";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031927";"";"0";"274.41";"0";"4.51";"69";"CC(C)c1ccc(NC(=O)NCC2CCCCC2)cc1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"32.65";"0.61";"4.45";"21.78";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL397693";"";"0";"476.61";"1";"5.85";"88";"CC(C)Oc1cc(F)c(CO[C@H]2CC[C@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c(F)c1";"IC50";"'='";"4.8";"nM";"8.32";"";"";"UO_0000065";"17.45";"0.33";"2.47";"13.96";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL245148";"";"0";"472.67";"1";"5.10";"106";"CCc1ccc(OCCOCCOCCCCCNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"18.55";"0.35";"3.67";"12.74";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031947";"";"0";"438.65";"0";"4.66";"108";"CCCC(C)OCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"6.2";"nM";"8.21";"";"";"UO_0000065";"18.71";"0.36";"3.55";"11.93";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL395738";"";"0";"418.53";"1";"5.06";"116";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OCc2c(F)cccc2F)CC1";"IC50";"'='";"1.4";"nM";"8.85";"";"";"UO_0000065";"21.15";"0.40";"3.79";"17.58";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031945";"";"0";"458.64";"0";"4.67";"105";"O=C(NCCCCCOCCOCCOCc1ccccc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"10.8";"nM";"7.97";"";"";"UO_0000065";"17.37";"0.33";"3.30";"11.58";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL3263291";"";"0";"490.69";"1";"6.36";"1e";"O=C(NCC12CC3CC(CC(C3)C1)C2)Nc1ccc(NC(=O)NCC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"779.6";"nM";"6.11";"";"";"UO_0000065";"12.45";"0.23";"-0.25";"7.43";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL2021549";"";"0";"427.50";"0";"3.89";"(S)-22";"CS(=O)(=O)c1ccc([C@@H](CCNC(=O)c2ccc(O)cc2)c2ccc(F)cc2)cc1";"EC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"20.51";"0.40";"4.88";"10.51";"False";"CHEMBL1058193";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL395988";"";"0";"382.55";"0";"4.78";"115";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2ccccc2)CC1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"23.42";"0.44";"4.18";"17.79";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL478320";"";"0";"314.39";"0";"3.48";"14";"O=C(Nc1cccc(C(=O)O)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"365.0";"nM";"6.44";"";"";"UO_0000065";"20.48";"0.38";"2.96";"8.21";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL558097";"";"0";"340.51";"0";"4.63";"1";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)O";"IC50";"'='";"46.0";"nM";"7.34";"";"";"UO_0000065";"21.55";"0.42";"2.71";"9.36";"False";"CHEMBL1063935";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus system assessed as appearance of 6-methoxynaphthaldehyde product by fluorescent-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1151961";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL460214";"";"0";"456.63";"0";"4.08";"16c";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)C(O)CCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"530.0";"nM";"6.28";"";"";"UO_0000065";"13.74";"0.26";"2.20";"8.84";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1087062";"";"0";"368.44";"0";"2.39";"5o,para isomer";"O=C(Nc1ccccc1)Nc1ccc(C(=O)NCCN2CCOCC2)cc1";"IC50";"'='";"320.0";"nM";"6.50";"";"";"UO_0000065";"17.63";"0.33";"4.10";"7.85";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1085746";"";"0";"380.27";"0";"4.14";"2, Table1";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccncc2)CC1";"IC50";"'='";"22.0";"nM";"7.66";"";"";"UO_0000065";"20.14";"0.42";"3.52";"14.06";"False";"CHEMBL1118602";"Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1078353";"";"0";"337.47";"0";"3.78";"1k";"CC1(c2ccccc2)CCCN(C(=O)NCCCc2cccnc2)C1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"24.16";"0.45";"4.37";"18.03";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2313159";"";"0";"423.54";"0";"3.89";"7-21";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc4ncccc4c3)CC2)c(C)c1";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"18.62";"0.36";"4.00";"9.94";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1818402";"";"0";"292.47";"0";"4.08";"21";"CCCCCCCNC(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"31.80";"0.60";"5.22";"22.61";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818395";"";"0";"312.41";"0";"3.84";"12";"CC(=O)c1cccc(NC(=O)NC2C3CC4CC(C3)CC2C4)c1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"29.77";"0.55";"5.46";"15.98";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818386";"";"0";"338.37";"0";"4.44";"3";"O=C(NCC12CC3CC(CC(C3)C1)C2)Nc1ccc(F)c(F)c1F";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"27.77";"0.53";"4.96";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1563200";"";"0";"236.36";"0";"2.52";"15";"CC(C)NC(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"84.4";"nM";"7.07";"";"";"UO_0000065";"29.93";"0.57";"4.55";"17.20";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818396";"";"0";"284.40";"0";"3.31";"13";"O=C(NCc1ccccc1)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"14.8";"nM";"7.83";"";"";"UO_0000065";"27.53";"0.51";"4.52";"19.04";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818388";"";"0";"326.36";"0";"4.30";"5";"CC1C(NC(=O)Nc2ccc(F)c(F)c2F)CC2CC1C2(C)C";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"28.80";"0.56";"5.10";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL3236511";"";"0";"600.49";"3";"1.47";"13";"C[C@@H]1O[C@@H](Oc2c(-c3ccc(O)c(O)c3)oc3cc(O)cc(O)c3c2=O)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](O)[C@H]1O";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL250450";"ISOQUERCETIN";"2";"464.38";"2";"-0.54";"9";"O=c1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL2392703";"";"0";"406.45";"0";"3.98";"15";"CNc1cc(C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)c1";"IC50";"'='";"1585.0";"nM";"5.80";"";"";"UO_0000065";"14.27";"0.27";"1.82";"10.13";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3327087";"";"0";"423.46";"0";"3.30";"32";"CCCCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"T1/2";"'='";"0.2167";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327073";"";"0";"471.42";"1";"5.13";"13";"CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)CC1";"T1/2";"'='";"0.6167";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL10835";"";"0";"350.03";"1";"5.94";"220";"O=C(Nc1ccc(Cl)c(Cl)c1)Nc1ccc(Cl)c(Cl)c1";"IC50";"'='";"-0.59";"";"";"Non standard unit for type";"";"";"";"";"";"";"False";"CHEMBL809079";"Inhibitory activity against human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1136721";"1";"Scientific Literature";"J. Med. Chem.";"2003";"None"
"CHEMBL11448";"";"0";"256.35";"0";"1.96";"91";"CC(C)(C)OC(=O)CNC(=O)NC1CCCCC1";"IC50";"'='";"1.28";"";"";"Non standard unit for type";"";"";"";"";"";"";"False";"CHEMBL809079";"Inhibitory activity against human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1136721";"1";"Scientific Literature";"J. Med. Chem.";"2003";"None"
"CHEMBL2392738";"";"0";"302.38";"0";"2.89";"50";"O=C(Nc1nnc(C2CC2)o1)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"2408.0";"nM";"5.62";"";"";"UO_0000065";"18.58";"0.35";"2.73";"7.02";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL4112730";"";"0";"432.97";"0";"3.49";"BDBM181783";"O=C(NCCCc1ccccc1)[C@H]1CCC12CN(S(=O)(=O)c1ccccc1Cl)C2";"IC50";"'='";"288.0";"nM";"6.54";"";"328790";"UO_0000065";"15.11";"0.31";"3.05";"9.84";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL66175";"";"0";"436.59";"0";"4.09";"24";"CCOC(=O)CCCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"15.85";"0.30";"2.83";"7.38";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL1358";"FULVESTRANT";"4";"606.78";"2";"8.68";"15G10";"C[C@]12CC[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCCCC[S+]([O-])CCCC(F)(F)C(F)(F)F)[C@H]3[C@@H]1CC[C@@H]2O";"Ki";"'='";"26.0";"nM";"7.58";"";"";"UO_0000065";"12.50";"0.25";"-1.09";"13.18";"False";"CHEMBL2400589";"Competitive inhibition of human recombinant soluble epoxide hydrolase using [3H]-tDPPO as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348399";"";"0";"305.31";"0";"2.20";"5j";"Cc1ccc(S(=O)(=O)Oc2cccc3oc(=O)[nH]c23)cc1";"Inhibition";"'='";"39.92";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2031918";"";"0";"440.59";"0";"3.23";"49, 134";"O=C(Nc1cccc(C(=O)NCCCN2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"57.9";"nM";"7.24";"";"";"UO_0000065";"16.43";"0.31";"4.01";"8.75";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1933489";"";"0";"370.54";"0";"4.30";"7";"Cc1cc(C)c(C(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c(C)c1";"IC50";"'='";"46.1";"nM";"7.34";"";"";"UO_0000065";"19.80";"0.37";"3.04";"14.85";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933490";"";"0";"356.55";"0";"4.66";"8";"Cc1cc(C)c(CN2CCC(C(=O)NC3CCCCCC3)CC2)c(C)c1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"19.41";"0.36";"2.26";"21.40";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933493";"";"0";"344.52";"0";"2.52";"14-2";"CC(C)CS(=O)(=O)N1CCC(C(=O)NC2CCCCCC2)CC1";"IC50";"'='";"960.0";"nM";"6.02";"";"";"UO_0000065";"17.47";"0.36";"3.50";"9.05";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933502";"";"0";"406.55";"0";"3.13";"14-12";"CC(=O)c1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"340.0";"nM";"6.47";"";"";"UO_0000065";"15.91";"0.32";"3.34";"7.74";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933507";"";"0";"443.41";"0";"3.69";"14-17";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(Br)cc2)CC1";"IC50";"'='";"560.0";"nM";"6.25";"";"";"UO_0000065";"14.10";"0.33";"2.56";"9.40";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933510";"";"0";"448.51";"0";"3.82";"14-20";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"1100.0";"nM";"5.96";"";"";"UO_0000065";"13.29";"0.27";"2.14";"7.87";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933650";"";"0";"511.40";"1";"4.71";"14-33";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2Br)CC1";"IC50";"'='";"56.0";"nM";"7.25";"";"";"UO_0000065";"14.18";"0.33";"2.54";"10.91";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933653";"";"0";"409.51";"0";"2.83";"14-36";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2cccc([N+](=O)[O-])c2)CC1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"16.90";"0.34";"4.09";"6.31";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933658";"";"0";"392.57";"0";"3.54";"14-41";"Cc1cc(C)cc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c1";"IC50";"'='";"2000.0";"nM";"5.70";"";"";"UO_0000065";"14.52";"0.29";"2.16";"8.57";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933660";"";"0";"460.96";"0";"3.42";"14-43";"O=C(O)c1cc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c(F)cc1Cl";"IC50";"'='";"6000.0";"nM";"5.22";"";"";"UO_0000065";"11.33";"0.24";"1.80";"5.03";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL3677982";"";"0";"513.94";"2";"6.22";"BDBM158491";"CC(C)(C)OC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)cn1";"IC50";"'='";"0.5";"nM";"9.30";"";"301047";"UO_0000065";"18.10";"0.36";"3.08";"10.39";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3677986";"";"0";"492.50";"0";"4.73";"BDBM158497";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccnc(C(=O)N3CCCC3)c2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"301056";"UO_0000065";"18.89";"0.36";"4.57";"10.02";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3263288";"";"0";"470.70";"0";"4.80";"1b";"O=C(NCCCCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"26.3";"nM";"7.58";"";"";"UO_0000065";"16.10";"0.30";"2.78";"9.21";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263292";"";"0";"496.74";"1";"5.14";"1f";"O=C(NCC1CCN(C(=O)NCC23CC4CC(CC(C4)C2)C3)CC1)NCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"39.7";"nM";"7.40";"";"";"UO_0000065";"14.90";"0.28";"2.26";"10.07";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263297";"";"0";"554.86";"2";"7.14";"3b";"CC(NC(=O)NCCCCCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"16.76";"0.32";"2.16";"11.31";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1257878";"";"0";"305.38";"0";"2.22";"BDBM50327820";"CCC(=O)N1CCC(NC(=O)Nc2ccc(OC)cc2)CC1";"IC50";"'='";"87.0";"nM";"7.06";"";"377018";"UO_0000065";"23.12";"0.44";"4.84";"9.99";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL2392727";"";"0";"316.41";"0";"3.43";"39";"O=C(Nc1nnc(C2CCC2)o1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"241.0";"nM";"6.62";"";"";"UO_0000065";"20.92";"0.39";"3.19";"8.27";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392763";"";"0";"300.36";"0";"2.95";"30";"Cc1noc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1C#N";"IC50";"'='";"25.0";"nM";"7.60";"";"";"UO_0000065";"25.31";"0.47";"4.65";"8.36";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392753";"";"0";"273.34";"0";"1.96";"20";"O=C(Nc1nccnn1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1012.0";"nM";"6.00";"";"";"UO_0000065";"21.93";"0.41";"4.03";"7.51";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL3103797";"";"0";"312.37";"0";"1.98";"3";"O=C(NCCCc1ccccc1)C(=O)NOCc1ccccc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL444191";"";"0";"600.49";"3";"0.74";"11";"O=C(O[C@H]1[C@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)O[C@H](CO)[C@@H](O)[C@@H]1O)c1cc(O)c(O)c(O)c1";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL249447";"";"0";"516.46";"3";"1.03";"3";"O=C(/C=C/c1ccc(O)c(O)c1)O[C@@H]1C[C@](O)(C(=O)O)C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@H]1O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL3103815";"";"0";"455.56";"0";"3.03";"22";"O=C(NOC1CCCCO1)C(=O)Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'>'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3263296";"";"0";"498.76";"1";"5.86";"3a";"O=C(NCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"997.0";"nM";"6.00";"";"";"UO_0000065";"12.03";"0.23";"0.14";"7.30";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263289";"";"0";"498.76";"1";"5.58";"1c";"O=C(NCCCCCCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2";"Ratio IC50";"'='";"2.0";"";"";"";"";"";"";"";"";"";"False";"CHEMBL3270580";"Ratio of IC50 for recombinant human soluble epoxide hydrolase in presence of 1 mg/mL BSA to IC50 for recombinant human soluble epoxide hydrolase in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1258337";"";"0";"401.25";"0";"2.81";"BDBM50327816";"CCC(=O)N1CCC(NC(=O)Nc2ccc(I)cc2)CC1";"IC50";"'='";"7.2";"nM";"8.14";"";"377030";"UO_0000065";"20.29";"0.53";"5.33";"13.25";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL215356";"";"0";"277.41";"0";"2.01";"I";"O=C(NC1CCNCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"300.0";"nM";"6.52";"";"";"UO_0000065";"23.51";"0.45";"4.51";"12.27";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1256163";"";"0";"275.35";"0";"2.21";"BDBM50327829";"CCC(=O)N1CCC(NC(=O)Nc2ccccc2)CC1";"IC50";"'='";"130.0";"nM";"6.89";"";"377010";"UO_0000065";"25.01";"0.47";"4.68";"11.21";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL308642";"";"0";"228.29";"0";"1.18";"4";"COC(=O)CCNC(=O)NC1CCCCC1";"IC50";"'='";"78000.0";"nM";"4.11";"";"";"UO_0000065";"17.99";"0.35";"2.93";"6.09";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL3236509";"";"0";"788.58";"3";"0.70";"9";"O=C(OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](O)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL226335";"RUTIN";"2";"610.52";"3";"-1.69";"18";"C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL302704";"";"0";"450.62";"0";"4.48";"33";"CCOC(=O)CCCCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC90";"'='";"720.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677486";"Tested for 90 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL201094";"FUBERIDAZOLE";"0";"184.20";"0";"2.82";"q";"c1coc(-c2nc3ccccc3[nH]2)c1";"Activity";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL3102106";"Binding affinity to soluble epoxide hydrolase (unknown origin) at 400 uM by STD-NMR assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL1313977";"";"0";"247.34";"0";"2.76";"r";"O=C(NCCOc1ccccc1)C1CCCCC1";"IC50";"'='";"3000.0";"nM";"5.52";"";"";"UO_0000065";"22.33";"0.42";"2.76";"14.41";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL3099590";"";"0";"199.21";"0";"2.41";"l";"Nc1ccc2[nH]c(-c3ccco3)nc2c1";"IC50";"'='";"18000.0";"nM";"4.75";"";"";"UO_0000065";"23.82";"0.43";"2.33";"6.99";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL2436565";"";"0";"497.46";"1";"5.07";"13";"O=C(Nc1ccc(OCC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"5.7";"nM";"8.24";"";"";"UO_0000065";"16.57";"0.32";"3.17";"13.32";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL192461";"";"0";"247.34";"0";"2.69";"c-3";"COc1ccc(CC(=O)NC2CCCCC2)cc1";"IC50";"'='";"4800.0";"nM";"5.32";"";"";"UO_0000065";"21.50";"0.40";"2.63";"13.88";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL2094355";"";"0";"238.29";"0";"2.65";"8";"O=C1CN(Cc2ccccc2)c2ccccc2N1";"IC50";"'='";"61000.0";"nM";"4.21";"";"";"UO_0000065";"17.69";"0.32";"1.56";"13.03";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL191355";"";"0";"217.31";"0";"2.68";"d-3";"O=C(Cc1ccccc1)NC1CCCCC1";"IC50";"'='";"14000.0";"nM";"4.85";"";"";"UO_0000065";"22.34";"0.41";"2.17";"16.68";"False";"CHEMBL828058";"Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139516";"1";"Scientific Literature";"J. Med. Chem.";"2005";"None"
"CHEMBL470604";"";"0";"455.41";"0";"4.33";"6-25";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C)c1";"IC50";"'='";"46.9";"nM";"7.33";"";"";"UO_0000065";"16.09";"0.35";"3.00";"11.02";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL480496";"";"0";"595.68";"2";"7.60";"6-26";"CC(C)(C)c1cc(C(C)(C)C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C(C)(C)C)c1";"IC50";"'='";"44.5";"nM";"7.35";"";"";"UO_0000065";"12.34";"0.26";"-0.25";"11.06";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469337";"";"0";"436.30";"0";"4.07";"6-28";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(C(=O)c2cccc([N+](=O)[O-])c2)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469339";"";"0";"470.19";"0";"4.92";"6-30";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(C(=O)c2ccc(Br)cc2)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469580";"";"0";"440.61";"0";"4.21";"8-45";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCc4ccccc43)CC2)c(C)c1";"IC50";"'='";"20.1";"nM";"7.70";"";"";"UO_0000065";"17.47";"0.34";"3.49";"11.58";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471859";"";"0";"413.75";"0";"2.89";"6-8";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)CCCl)CC1";"Inhibition";"'='";"31.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469337";"";"0";"436.30";"0";"4.07";"6-28";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(C(=O)c2cccc([N+](=O)[O-])c2)CC1";"Inhibition";"'='";"18.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512722";"";"0";"484.41";"0";"3.67";"6-18";"CC(=O)Nc1ccc(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"Inhibition";"'='";"53.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL516182";"";"0";"473.62";"0";"4.27";"8-15";"COc1ccc2nc(NC(=O)C3CCN(S(=O)(=O)c4c(C)cc(C)cc4C)CC3)sc2c1";"Inhibition";"'='";"-17.0";"%";"";"Outside typical range";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472423";"";"0";"483.46";"0";"4.94";"8-38";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3c(C)cc(Cl)cc3Cl)CC2)c(C)c1";"Inhibition";"'='";"95.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469579";"";"0";"493.67";"0";"3.53";"8-44";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCN(C(=O)OC(C)(C)C)CC3)CC2)c(C)c1";"Inhibition";"'='";"88.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL224579";"";"0";"532.77";"2";"8.05";"15";"O=C(NCCCCCCCCCCCC(=O)OCc1cccc2ccccc12)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"210.0";"nM";"6.68";"";"";"UO_0000065";"12.53";"0.23";"-1.37";"9.90";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224740";"";"0";"448.69";"1";"6.50";"11";"CC(C)(C)OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"15.60";"0.30";"0.50";"10.38";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL427070";"";"0";"434.67";"1";"6.11";"7";"CC(C)OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"16.10";"0.31";"0.89";"10.38";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224580";"";"0";"419.65";"1";"5.29";"16";"CCNC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"4.3";"nM";"8.37";"";"";"UO_0000065";"19.94";"0.38";"3.08";"11.91";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL224359";"";"0";"434.67";"1";"6.11";"4";"CCCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"20.71";"0.40";"2.89";"13.35";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL476614";"";"0";"344.41";"0";"3.27";"36";"COC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1O";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"25.90";"0.49";"5.65";"10.18";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL70175";"";"0";"200.28";"0";"1.00";"5";"O=C(NCCCO)NC1CCCCC1";"IC50";"'>'";"500000.0";"nM";"";"Outside typical range";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL496189";"";"0";"376.46";"0";"3.75";"rac-1a";"O=C1CC2(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)Oc2ccccc21";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"22.64";"0.42";"4.77";"14.53";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL522211";"";"0";"363.46";"0";"3.51";"ent-1l";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC2(CCc3ncccc3O2)CC1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"22.84";"0.42";"4.79";"15.24";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2425008";"";"0";"473.99";"0";"3.89";"8i";"Cc1cc(C2CCN(C(=O)Nc3ccccc3Cl)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2425003";"";"0";"419.55";"0";"2.52";"8d";"CCCCNC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(N)(=O)=O)cc2)CC1";"IC50";"'='";"10082.0";"nM";"5.00";"";"";"UO_0000065";"11.91";"0.24";"2.48";"4.53";"False";"CHEMBL2427204";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL1096115";"";"0";"424.40";"0";"3.88";"6a, meta isomer";"CN1CCN(C(=O)c2cc(NC(=O)Nc3ccc(C(F)(F)F)cc3)ccc2F)CC1";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"18.37";"0.35";"3.92";"12.05";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2424996";"";"0";"438.55";"0";"3.16";"7c";"Cc1ccc(C(=O)N2CCC(c3cc(C)nn3-c3ccc(S(N)(=O)=O)cc3)CC2)cc1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2392726";"";"0";"302.38";"0";"3.04";"38";"O=C(Nc1nnc(C2CC2)o1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"503.0";"nM";"6.30";"";"";"UO_0000065";"20.83";"0.39";"3.26";"7.87";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392748";"";"0";"271.36";"0";"3.17";"14";"O=C(Nc1ccncc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"174.0";"nM";"6.76";"";"";"UO_0000065";"24.91";"0.46";"3.59";"12.51";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL3322803";"";"0";"417.62";"0";"3.62";"BDBM50057446";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)NS(C)(=O)=O";"IC50";"'='";"71.0";"nM";"7.15";"";"423463";"UO_0000065";"17.12";"0.35";"3.53";"6.85";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3558236";"";"0";"376.48";"0";"4.33";"BDBM62371";"CCCCCNC(=O)NCCCC/C=C\CCCCCCP(=O)(O)O";"IC50";"'>'";"500.0";"nM";"";"";"423464";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322823";"";"0";"397.59";"0";"4.50";"BDBM50057635";"CCCCCNC(=O)NCCCC/C=C\CCCCCC1SC(=O)NC1=O";"IC50";"'='";"57.0";"nM";"7.24";"";"423478";"UO_0000065";"18.22";"0.37";"2.74";"8.30";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL2392731";"";"0";"316.45";"0";"3.69";"43";"CCCn1nc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1C";"IC50";"'='";"751.0";"nM";"6.12";"";"";"UO_0000065";"19.35";"0.36";"2.43";"10.39";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392705";"";"0";"405.46";"0";"4.59";"17";"CNc1cc(C)cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL517099";"";"0";"444.48";"0";"3.61";"7";"O=S(=O)(Nc1cccc(OCCCN2CCOCC2)c1)c1ccc(C(F)(F)F)cc1";"IC50";"'='";"15000.0";"nM";"4.82";"";"";"UO_0000065";"10.85";"0.22";"1.21";"7.11";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471224";"";"0";"391.51";"0";"4.78";"19a";"O=C(Nc1ccc(OCc2ccccc2)cc1)C(O)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"310.0";"nM";"6.51";"";"";"UO_0000065";"16.62";"0.31";"1.73";"11.11";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1079258";"";"0";"454.88";"1";"5.79";"3b";"O=C(O)CCC1(c2cccc(C(F)(F)F)c2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"17.41";"0.35";"2.13";"11.37";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1079360";"";"0";"328.84";"0";"4.93";"1a";"CC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"27.37";"0.53";"4.07";"27.83";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1080975";"";"0";"418.97";"1";"6.27";"1g";"CC1(c2ccccc2)CCCN(C(=O)NCc2ccc(-c3cccc(Cl)c3)cc2)C1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"18.75";"0.36";"1.58";"24.29";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL67041";"";"0";"506.73";"2";"6.04";"36";"CCOC(=O)CCCCCCCCCCCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"13.81";"0.27";"0.96";"7.47";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL1079256";"";"0";"386.88";"0";"4.77";"entA-2b";"O=C(O)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"21.46";"0.42";"3.53";"11.92";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078337";"";"0";"387.87";"0";"4.17";"3e";"O=C(O)CCC1(c2cccnc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL11552";"";"0";"296.50";"1";"5.15";"329";"CCCCCCCCCCCCNC(=O)NC1CCCC1";"IC50";"'='";"-0.26";"";"";"Non standard unit for type";"";"";"";"";"";"";"False";"CHEMBL809079";"Inhibitory activity against human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1136721";"1";"Scientific Literature";"J. Med. Chem.";"2003";"None"
"CHEMBL3103812";"";"0";"427.55";"0";"3.30";"19";"CC(C)(C)ONC(=O)C(=O)Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"408.0";"nM";"6.39";"";"";"UO_0000065";"14.94";"0.28";"3.09";"6.62";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL511285";"";"0";"431.58";"1";"5.10";"20c";"O=C(CC12CC3CC(CC(C3)C1)C2)C(=O)NCCc1ccc(OCc2ccccc2)cc1";"IC50";"'='";"1540.0";"nM";"5.81";"";"";"UO_0000065";"13.47";"0.25";"0.71";"10.49";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3114616";"";"0";"338.41";"0";"2.59";"9";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2cnccn2)CC1";"IC50";"'='";"26.7";"nM";"7.57";"";"";"UO_0000065";"22.38";"0.41";"4.98";"11.24";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL562869";"";"0";"325.42";"0";"2.26";"1b";"Cn1cc(C2CCN(C(=O)NC3CC3c3ccccc3)CC2)nn1";"IC50";"'='";"2208.0";"nM";"5.66";"";"";"UO_0000065";"17.38";"0.32";"3.40";"8.97";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL395988";"";"0";"382.55";"0";"4.78";"3a";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2ccccc2)CC1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"22.92";"0.43";"3.99";"17.41";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL565941";"";"0";"355.32";"1";"5.65";"7z";"FC(F)(F)c1ccc(Nc2noc3cc(-c4cccnc4)ccc23)cc1";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"21.50";"0.40";"1.99";"14.99";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3634699";"";"0";"596.54";"3";"-2.03";"10";"COc1cc(O[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)c2c(O)c3c(=O)cc(C)oc3cc2c1";"Inhibition";"'='";"50.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL471241";"";"0";"380.55";"0";"3.17";"8-1";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCCC(C)C)CC2)c(C)c1";"IC50";"'='";"25.1";"nM";"7.60";"";"";"UO_0000065";"19.97";"0.40";"4.43";"11.43";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471649";"";"0";"557.30";"2";"5.02";"6-10";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2cccc3cncc(Br)c23)CC1";"Inhibition";"'='";"37.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL592742";"";"0";"457.38";"0";"4.15";"44";"CS(=O)(=O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"IC50";"'='";"5.6";"nM";"8.25";"";"";"UO_0000065";"18.04";"0.39";"4.10";"10.90";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2180628";"";"0";"355.44";"0";"3.37";"6a";"O=C(NCc1ccccc1Cn1cccc1C(=O)O)NC1CCCCC1";"IC50";"'='";"747.0";"nM";"6.13";"";"";"UO_0000065";"17.24";"0.32";"2.76";"7.35";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL1080974";"";"0";"452.52";"1";"6.64";"1f";"CC1(c2ccccc2)CCCN(C(=O)NCc2ccc(-c3ccccc3C(F)(F)F)cc2)C1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"17.89";"0.34";"1.46";"25.04";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL567109";"";"0";"296.16";"0";"2.90";"8";"Nc1ccc(C(=O)NCc2ccc(Cl)cc2Cl)cn1";"IC50";"'='";"520.0";"nM";"6.28";"";"";"UO_0000065";"21.22";"0.45";"3.38";"9.24";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078264";"";"0";"423.56";"1";"6.10";"1i";"CC1(c2ccccc2)CCCN(C(=O)NCc2ccc(-c3ccc4[nH]ccc4c3)cc2)C1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"19.25";"0.35";"2.05";"16.94";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078354";"";"0";"362.48";"0";"3.87";"1l";"CC1(c2ccccc2)CCCN(C(=O)NCCc2ccc3nc[nH]c3c2)C1";"IC50";"'='";"29.0";"nM";"7.54";"";"";"UO_0000065";"20.79";"0.38";"3.67";"12.35";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078452";"";"0";"374.49";"0";"3.94";"1m";"CC1(c2ccccc2)CCCN(C(=O)NCCc2ccc3nccnc3c2)C1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"22.17";"0.40";"4.36";"14.28";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1078452";"";"0";"374.49";"0";"3.94";"1m";"CC1(c2ccccc2)CCCN(C(=O)NCCc2ccc3nccnc3c2)C1";"IC50";"'='";"3000.0";"nM";"5.52";"";"";"UO_0000065";"14.75";"0.27";"1.58";"9.50";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1077780";"";"0";"334.46";"0";"4.31";"1n";"CC1(c2ccccc2)CCCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)C1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"26.91";"0.49";"4.69";"27.83";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL561379";"";"0";"312.37";"0";"2.51";"1g";"O=C(NC1CC1c1ccccc1)N1CCC(c2nnco2)CC1";"IC50";"'='";"235.0";"nM";"6.63";"";"";"UO_0000065";"21.22";"0.39";"4.12";"9.30";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL561259";"";"0";"312.37";"0";"2.51";"1h";"O=C(NC1CC1c1ccccc1)N1CCC(c2ncon2)CC1";"IC50";"'='";"54.0";"nM";"7.27";"";"";"UO_0000065";"23.27";"0.43";"4.76";"10.20";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL561259";"";"0";"312.37";"0";"2.51";"1h";"O=C(NC1CC1c1ccccc1)N1CCC(c2ncon2)CC1";"IC50";"'='";"333.0";"nM";"6.48";"";"";"UO_0000065";"20.74";"0.38";"3.97";"9.09";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL564547";"";"0";"326.40";"0";"2.82";"1i";"Cc1noc(C2CCN(C(=O)NC3CC3c3ccccc3)CC2)n1";"IC50";"'='";"28.0";"nM";"7.55";"";"";"UO_0000065";"23.14";"0.43";"4.73";"10.60";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL552382";"";"0";"389.46";"0";"3.58";"entB-2d";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"9.0";"nM";"8.05";"";"";"UO_0000065";"20.66";"0.38";"4.47";"9.56";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL557032";"";"0";"390.45";"0";"2.97";"2g";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3cnccn3)no2)CC1";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"20.20";"0.37";"4.92";"8.13";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL567110";"";"0";"408.30";"0";"4.24";"39";"O=C(NCc1ccccc1OC(F)(F)F)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"21.0";"nM";"7.68";"";"";"UO_0000065";"18.80";"0.37";"3.44";"12.70";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL567703";"";"0";"478.49";"0";"4.41";"42";"CS(=O)(=O)c1ccc(-c2ccc(CNC(=O)c3ccc(OCCC(F)(F)F)nc3)cc2)cc1";"IC50";"'='";"24.0";"nM";"7.62";"";"";"UO_0000065";"15.92";"0.32";"3.21";"8.93";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL3984594";"";"0";"420.30";"0";"3.72";"BDBM181770";"O=C(O)c1ccc(N2CC3(CN(C(=O)NCc4ccc(Cl)cc4Cl)C3)C2)cc1";"IC50";"'='";"1260.0";"nM";"5.90";"";"328777";"UO_0000065";"14.04";"0.29";"2.18";"8.09";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL560740";"";"0";"450.41";"1";"5.25";"13";"O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1ccc(OCC(F)(F)F)nc1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"18.43";"0.35";"3.05";"16.21";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL470363";"";"0";"432.61";"1";"5.71";"21";"O=C(NCCc1ccc(OCc2ccccc2)cc1)NCCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"18.09";"0.33";"2.11";"15.54";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL540430";"";"0";"355.44";"0";"3.43";"12d";"O=C(Nc1ccccc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"38.0";"nM";"7.42";"";"";"UO_0000065";"20.88";"0.39";"3.99";"11.81";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL560321";"";"0";"409.41";"0";"3.85";"12h";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)Nc1c(F)cc(F)cc1F";"IC50";"'='";"1880.0";"nM";"5.73";"";"";"UO_0000065";"13.99";"0.27";"1.88";"9.11";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL563753";"";"0";"424.33";"0";"4.74";"12m";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)Nc1c(Cl)cccc1Cl";"IC50";"'='";"10000.0";"nM";"5.00";"";"";"UO_0000065";"11.78";"0.24";"0.26";"7.96";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL558639";"";"0";"373.43";"0";"3.57";"13d";"O=C(Nc1ccccc1)Nc1ccc(F)c(OCCCN2CCOCC2)c1";"IC50";"'='";"81.0";"nM";"7.09";"";"";"UO_0000065";"18.99";"0.36";"3.52";"11.29";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL495992";"";"0";"453.54";"0";"4.81";"rac-1b";"O=C1CC2(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)Oc2ccc(-c3ccncc3)cc21";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.84";"0.36";"4.19";"12.58";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL519336";"";"0";"440.57";"0";"3.52";"ent-1h";"CS(=O)(=O)c1ccc2c(c1)CCC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL516890";"";"0";"300.40";"0";"3.79";"6";"COc1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"4.7";"nM";"8.33";"";"";"UO_0000065";"27.72";"0.52";"4.54";"16.54";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL476057";"";"0";"390.48";"0";"5.00";"9";"O=C(Nc1cccc(OC(=O)c2ccccc2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"5.1";"nM";"8.29";"";"";"UO_0000065";"21.24";"0.39";"3.29";"12.30";"True";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471858";"";"0";"506.25";"1";"4.47";"6-7";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccccc2Br)CC1";"IC50";"'='";"91.1";"nM";"7.04";"";"";"UO_0000065";"13.91";"0.34";"2.57";"10.59";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL471859";"";"0";"413.75";"0";"2.89";"6-8";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)CCCl)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1818413";"";"0";"338.37";"0";"4.07";"33";"CN(C(=O)NC1C2CC3CC(C2)CC1C3)c1ccc(F)c(F)c1F";"IC50";"'='";"38.1";"nM";"7.42";"";"";"UO_0000065";"21.93";"0.42";"3.35";"22.94";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818403";"";"0";"282.81";"0";"4.74";"23";"CCCCCCCNC(=O)Nc1ccc(C)c(Cl)c1";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"31.10";"0.63";"4.06";"21.39";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818389";"";"0";"326.36";"0";"4.30";"6";"CC1(C)C2CCC(CNC(=O)Nc3ccc(F)c(F)c3F)C1C2";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"28.80";"0.56";"5.10";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818385";"";"0";"324.35";"0";"4.19";"2";"O=C(Nc1ccc(F)c(F)c1F)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"28.97";"0.56";"5.21";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818384";"";"0";"324.35";"0";"4.05";"1";"O=C(Nc1ccc(F)c(F)c1F)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"28.97";"0.56";"5.35";"22.85";"True";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1078565";"";"0";"400.91";"1";"5.16";"2c";"O=C(O)CCCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"6000.0";"nM";"5.22";"";"";"UO_0000065";"13.02";"0.25";"0.06";"7.50";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1079140";"";"0";"385.94";"0";"4.86";"2j";"CN(C)CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"1300.0";"nM";"5.89";"";"";"UO_0000065";"15.25";"0.30";"1.03";"16.54";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1078715";"";"0";"454.88";"1";"5.79";"3c";"O=C(O)CCC1(c2ccc(C(F)(F)F)cc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"18.25";"0.37";"2.51";"11.92";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1079291";"";"0";"372.90";"0";"4.68";"2h";"O=C(Nc1ccc(Cl)cc1)N1CCCC(CCCO)(c2ccccc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL576420";"";"0";"329.33";"0";"4.77";"6f";"FC(F)(F)c1cccc(CNc2cc(-c3ccccc3)ncn2)c1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1615212";"";"0";"262.31";"0";"2.84";"1";"N#Cc1ccc(C(=O)N[C@H]2C[C@@H]2c2ccccc2)cc1";"Activity";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL1680919";"Binding affinity to human soluble epoxide hydrolase by X-ray crystallography";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1672129";"";"0";"279.30";"0";"2.51";"7";"O=C(N[C@H]1C[C@@H]1c1ccccc1)c1ccc2nonc2c1";"pIC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1680922";"Inhibition of soluble epoxide hydrolase in human HepG2 cells after 30 mins";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"CHEMBL3307718"
"CHEMBL1672130";"";"0";"307.35";"0";"3.81";"8";"Cc1nc2cc(NC(=O)N[C@H]3C[C@@H]3c3ccccc3)ccc2o1";"IC50";"'='";"81.28";"nM";"7.09";"";"";"UO_0000065";"23.07";"0.42";"3.28";"10.56";"False";"CHEMBL1680922";"Inhibition of soluble epoxide hydrolase in human HepG2 cells after 30 mins";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"CHEMBL3307718"
"CHEMBL1672131";"";"0";"309.41";"0";"3.11";"9";"CN(C)c1ccc(CNC(=O)N[C@H]2C[C@@H]2c2ccccc2)cc1";"IC50";"'='";"30.2";"nM";"7.52";"";"";"UO_0000065";"24.30";"0.45";"4.41";"16.95";"False";"CHEMBL1680920";"Inhibition of human soluble epoxide hydrolase in cell free system";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1672132";"";"0";"335.45";"0";"3.51";"10";"O=C(NC1CCN(c2ccccc2)CC1)N[C@H]1C[C@@H]1c1ccccc1";"IC50";"'='";"7.943";"nM";"8.10";"";"";"UO_0000065";"24.15";"0.44";"4.59";"18.26";"False";"CHEMBL1680922";"Inhibition of soluble epoxide hydrolase in human HepG2 cells after 30 mins";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"CHEMBL3307718"
"CHEMBL1615216";"";"0";"354.45";"0";"3.64";"11";"CC(C)c1noc(C2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)n1";"IC50";"'='";"13.18";"nM";"7.88";"";"";"UO_0000065";"22.23";"0.41";"4.24";"11.06";"False";"CHEMBL1680922";"Inhibition of soluble epoxide hydrolase in human HepG2 cells after 30 mins";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"CHEMBL3307718"
"CHEMBL1615216";"";"0";"354.45";"0";"3.64";"11";"CC(C)c1noc(C2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)n1";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"22.25";"0.41";"4.25";"11.07";"False";"CHEMBL1680922";"Inhibition of soluble epoxide hydrolase in human HepG2 cells after 30 mins";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"CHEMBL3307718"
"CHEMBL1097523";"";"0";"420.44";"0";"4.18";"5l, meta isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(C(=O)NCCN2CCCC2)c1";"IC50";"'='";"68.0";"nM";"7.17";"";"";"UO_0000065";"17.05";"0.33";"2.99";"9.76";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1096767";"";"0";"359.81";"0";"3.46";"5x, meta isomer";"O=C(Nc1ccc(Cl)cc1)Nc1cccc(C(=O)N2CCOCC2)c1";"IC50";"'='";"49.0";"nM";"7.31";"";"";"UO_0000065";"20.32";"0.40";"3.85";"10.34";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088682";"";"0";"406.41";"0";"3.74";"5h,para isomer";"CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)cc2)CC1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"19.32";"0.37";"4.11";"12.14";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087492";"";"0";"450.42";"0";"2.94";"5aa,para isomer";"O=C(Nc1ccc(C(=O)NCC(=O)N2CCOCC2)cc1)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"18.92";"0.36";"5.58";"8.54";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088689";"";"0";"428.37";"1";"5.28";"5e, meta isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(C(=O)c2ccc(C(=O)O)cc2)c1";"IC50";"'='";"27.0";"nM";"7.57";"";"";"UO_0000065";"17.67";"0.33";"2.29";"7.93";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087716";"";"0";"371.44";"0";"2.59";"5a,para isomer";"O=C(O)CNC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"490.0";"nM";"6.31";"";"";"UO_0000065";"16.99";"0.32";"3.72";"5.87";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087854";"";"0";"415.49";"0";"2.61";"5d,para isomer";"O=C(O)COCCNC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"80.0";"nM";"7.10";"";"";"UO_0000065";"17.08";"0.32";"4.49";"6.08";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087491";"";"0";"409.36";"0";"3.70";"5z,para isomer";"O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccc(C(=O)N2CCOCC2)cc1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"20.51";"0.40";"4.70";"10.51";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087722";"";"0";"403.50";"0";"2.83";"13a, meta isomer";"O=C(Nc1ccccc1)Nc1cccc(S(=O)(=O)CCCN2CCOCC2)c1";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"17.35";"0.34";"4.17";"7.98";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL3104617";"";"0";"483.44";"0";"4.52";"20";"O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"18.38";"0.36";"4.37";"14.36";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL434749";"";"0";"397.28";"1";"5.64";"1{39}";"O=C(Nc1c(Cl)cccc1Cl)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"1.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL2424663";"";"0";"437.57";"0";"3.91";"6c";"Cc1ccc(C(=O)N2CCC(c3cc(C)nn3-c3ccc(S(C)(=O)=O)cc3)CC2)cc1";"Inhibition";"'='";"42.08";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2392693";"";"0";"476.55";"0";"4.51";"10c";"CNc1nc(C2CCCCC2)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"18.89";"0.36";"4.49";"10.84";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL556487";"";"0";"389.46";"0";"3.58";"2f";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccncc3)no2)CC1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"20.17";"0.37";"4.27";"9.33";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL560384";"";"0";"431.55";"0";"4.02";"13c";"O=C(Nc1ccc(F)c(OCCCN2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"21.08";"0.40";"5.08";"14.48";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL555347";"";"0";"417.39";"0";"4.56";"3a";"O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC(c2nc(-c3ccccn3)no2)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"19.54";"0.37";"3.59";"9.69";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL458165";"";"0";"413.56";"0";"3.88";"12c";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"22.00";"0.41";"5.22";"14.48";"True";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL559101";"";"0";"310.40";"0";"2.79";"1e";"O=C(NC1CC1c1ccccc1)N1CCC(n2cccn2)CC1";"IC50";"'='";"480.0";"nM";"6.32";"";"";"UO_0000065";"20.36";"0.38";"3.53";"12.60";"False";"CHEMBL1051702";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL1668938";"";"0";"330.43";"0";"2.32";"14q";"O=C(NC1CCCCC1)NC1CCN(C(=O)c2ccccn2)CC1";"IC50";"'='";"6.4";"nM";"8.19";"";"";"UO_0000065";"24.80";"0.47";"5.87";"11.02";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL591789";"";"0";"331.20";"0";"3.00";"19";"O=C(O)C1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"'='";"1000.0";"nM";"6.00";"";"";"UO_0000065";"18.12";"0.39";"3.00";"8.62";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL589136";"";"0";"381.26";"0";"3.54";"33";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ncccn2)CC1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"20.52";"0.43";"4.28";"11.62";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1085744";"";"0";"395.38";"0";"3.73";"5, Table1";"O=C(NCc1ccccc1OC(F)(F)F)N1CCC(Oc2ccncc2)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1118602";"Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1672131";"";"0";"309.41";"0";"3.11";"9";"CN(C)c1ccc(CNC(=O)N[C@H]2C[C@@H]2c2ccccc2)cc1";"pIC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1680922";"Inhibition of soluble epoxide hydrolase in human HepG2 cells after 30 mins";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"CHEMBL3307718"
"CHEMBL2313186";"";"0";"364.51";"0";"2.76";"7-3";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCC3)CC2)c(C)c1";"IC50";"'='";"5.2";"nM";"8.28";"";"";"UO_0000065";"22.73";"0.45";"5.52";"12.46";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1615216";"";"0";"354.45";"0";"3.64";"11";"CC(C)c1noc(C2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)n1";"IC50";"'='";"8.511";"nM";"8.07";"";"";"UO_0000065";"22.77";"0.42";"4.43";"11.32";"False";"CHEMBL1680920";"Inhibition of human soluble epoxide hydrolase in cell free system";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1632481";"";"0";"512.70";"2";"5.10";"20b";"CC(C)(C)OC(=O)N1CCN(CCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"2.9";"nM";"8.54";"";"";"UO_0000065";"16.65";"0.32";"3.44";"10.27";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257517";"";"0";"399.29";"0";"3.26";"BDBM50327847";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C(F)(F)F)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"377050";"UO_0000065";"23.54";"0.48";"6.14";"13.30";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL559531";"";"0";"432.48";"0";"3.88";"2c";"O=C(O)c1ccc(-c2noc(C3CCN(C(=O)NC4CC4c4ccccc4)CC3)n2)cc1";"IC50";"'='";"190.0";"nM";"6.72";"";"";"UO_0000065";"15.54";"0.29";"2.84";"6.19";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL1258903";"";"0";"457.39";"0";"4.81";"BDBM50327824";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2C)CC1";"IC50";"'='";"17.0";"nM";"7.77";"";"377042";"UO_0000065";"16.99";"0.34";"2.96";"12.65";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1729370";"";"0";"382.50";"0";"3.07";"14-25";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(F)cc2)CC1";"IC50";"'='";"1900.0";"nM";"5.72";"";"";"UO_0000065";"14.96";"0.30";"2.65";"8.61";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933652";"";"0";"378.54";"0";"3.23";"14-35";"Cc1cccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c1";"IC50";"'='";"1700.0";"nM";"5.77";"";"";"UO_0000065";"15.24";"0.30";"2.54";"8.68";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933654";"";"0";"408.52";"0";"2.62";"14-37";"O=C(O)c1cccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c1";"IC50";"'='";"150.0";"nM";"6.82";"";"";"UO_0000065";"16.70";"0.33";"4.20";"6.58";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933666";"";"0";"449.44";"0";"3.75";"14-49";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(Br)s2)CC1";"IC50";"'='";"710.0";"nM";"6.15";"";"";"UO_0000065";"13.68";"0.34";"2.40";"9.25";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933673";"";"0";"346.45";"0";"3.52";"15-6";"O=C(NC1CCCCCC1)C1CCN(C(=O)c2ccccc2F)CC1";"IC50";"'='";"92.0";"nM";"7.04";"";"";"UO_0000065";"20.31";"0.38";"3.52";"14.24";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933659";"";"0";"490.75";"1";"6.30";"14-42";"CC(C)c1cc(C(C)C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c(C(C)C)c1";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"15.89";"0.31";"1.50";"11.73";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933669";"";"0";"358.48";"0";"3.39";"15-1";"COc1ccc(C(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"16.52";"0.31";"2.53";"10.10";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1632475";"";"0";"412.58";"0";"3.40";"15b";"CN1CCN(CCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"7.8";"nM";"8.11";"";"";"UO_0000065";"19.65";"0.37";"4.71";"14.26";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632476";"";"0";"454.66";"0";"4.57";"18b";"CN1CCN(CCCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"11.5";"nM";"7.94";"";"";"UO_0000065";"17.46";"0.33";"3.37";"13.97";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632480";"";"0";"540.75";"2";"5.88";"22b";"CC(C)(C)OC(=O)N1CCN(CCCCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"11.7";"nM";"7.93";"";"";"UO_0000065";"14.67";"0.28";"2.05";"9.54";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL2158536";"";"0";"413.84";"0";"3.17";"1";"O=C(Nc1cccc(Cl)c1)OCCCNS(=O)(=O)c1cccc([N+](=O)[O-])c1";"IC50";"'='";"3200.0";"nM";"5.50";"";"";"UO_0000065";"13.28";"0.28";"2.32";"4.30";"False";"CHEMBL2162306";"Inhibition of sEH using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to substrate addition measured every min for 15 mins by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2157944";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933491";"";"0";"406.59";"0";"3.85";"13";"Cc1cc(C)c(S(=O)(=O)N2CCC(NC(=O)C3CCCCCC3)CC2)c(C)c1";"IC50";"'='";"22.0";"nM";"7.66";"";"";"UO_0000065";"18.83";"0.37";"3.81";"11.52";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933494";"";"0";"330.49";"0";"2.28";"14-3";"CC(C)S(=O)(=O)N1CCC(C(=O)NC2CCCCCC2)CC1";"IC50";"'='";"490.0";"nM";"6.31";"";"";"UO_0000065";"19.09";"0.39";"4.03";"9.49";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933501";"";"0";"394.54";"0";"2.93";"14-11";"COc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)cc1";"IC50";"'='";"450.0";"nM";"6.35";"";"";"UO_0000065";"16.09";"0.32";"3.42";"8.38";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1933511";"";"0";"380.51";"0";"2.63";"14-21";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2ccc(O)cc2)CC1";"IC50";"'='";"140.0";"nM";"6.85";"";"";"UO_0000065";"18.01";"0.36";"4.22";"7.90";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL3913775";"";"0";"447.65";"1";"6.01";"BDBM242782";"CCCCCCC(=O)N(CCCCCOc1cccc2nc(NC(C)=O)sc12)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"423491";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL93836";"VALPROMIDE";"0";"143.23";"0";"1.69";"Valpromide";"CCCC(CCC)C(N)=O";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3628776";"";"0";"505.64";"2";"6.50";"23";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"0.96";"nM";"9.02";"";"";"UO_0000065";"17.83";"0.35";"2.52";"10.17";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL579041";"";"0";"277.25";"0";"4.33";"7c";"FC(F)(F)c1ccc(Nc2n[nH]c3ccccc23)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL578151";"";"0";"347.22";"1";"5.00";"7jj";"FC(F)(F)c1ccc(Nc2noc3c(C(F)(F)F)nccc23)cc1";"IC50";"'='";"19.0";"nM";"7.72";"";"";"UO_0000065";"22.24";"0.44";"2.72";"15.15";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3706856";"";"0";"641.81";"2";"4.84";"2";"O=C(CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O";"Ki";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"12.19";"0.23";"2.98";"5.13";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL224359";"";"0";"434.67";"1";"6.11";"4";"CCCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"16.10";"0.31";"0.89";"10.38";"False";"CHEMBL918224";"Inhibition of human soluble epoxide hydrolase by spectrometric based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL2180623";"";"0";"435.57";"0";"4.48";"5e";"CCOC(=O)c1cccn1Cc1cccc(CNC(=O)NC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c1";"IC50";"'='";"46.0";"nM";"7.34";"";"";"UO_0000065";"16.85";"0.31";"2.86";"10.14";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL384280";"";"0";"453.58";"0";"3.59";"8c";"COC(=O)c1ccccc1C(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"19.28";"0.36";"5.15";"9.97";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL217711";"";"0";"405.54";"0";"2.45";"8a";"COC(=O)CCC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"6.2";"nM";"8.21";"";"";"UO_0000065";"20.24";"0.39";"5.76";"9.35";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL385348";"";"0";"377.49";"0";"2.11";"7f";"O=C(O)CCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"250.0";"nM";"6.60";"";"";"UO_0000065";"17.49";"0.33";"4.49";"6.69";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL216016";"";"0";"381.52";"0";"3.56";"5e";"O=C(NC1CCN(C(=O)c2ccccc2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"23.29";"0.43";"5.33";"14.46";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3896100";"";"0";"404.30";"0";"3.66";"BDBM181786";"O=C(NCc1ccc(Cl)cc1Cl)N1CC2CN(C(=O)c3ccccc3)C2C1";"IC50";"'='";"183.0";"nM";"6.74";"";"328793";"UO_0000065";"16.66";"0.34";"3.08";"12.80";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL1079245";"";"0";"455.95";"0";"2.69";"2l";"O=C(CCC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1)NC1=NNNN1";"IC50";"'='";"1400.0";"nM";"5.85";"";"";"UO_0000065";"12.84";"0.25";"3.16";"5.33";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1078715";"";"0";"454.88";"1";"5.79";"3c";"O=C(O)CCC1(c2ccc(C(F)(F)F)cc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'<'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1077781";"";"0";"372.85";"0";"4.38";"2a";"O=C(O)CC1(c2ccccc2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"38000.0";"nM";"4.42";"";"";"UO_0000065";"11.86";"0.23";"0.04";"6.35";"False";"CHEMBL1100145";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL1079290";"";"0";"358.87";"0";"4.29";"2g";"O=C(Nc1ccc(Cl)cc1)N1CCCC(CCO)(c2ccccc2)C1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"25.08";"0.49";"4.71";"17.12";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL585011";"";"0";"294.23";"0";"4.47";"7n";"FC(F)(F)Oc1cccc(Nc2noc3ccccc23)c1";"IC50";"'='";"160.0";"nM";"6.80";"";"";"UO_0000065";"23.10";"0.44";"2.33";"14.37";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL577689";"";"0";"347.22";"1";"5.00";"7ee";"FC(F)(F)c1ccc(Nc2noc3c(C(F)(F)F)cccc23)nc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL576833";"";"0";"422.33";"1";"7.28";"7x";"FC(F)(F)c1ccc(Nc2noc3cc(-c4cccc(C(F)(F)F)c4)ccc23)cc1";"IC50";"'='";"470.0";"nM";"6.33";"";"";"UO_0000065";"14.98";"0.29";"-0.95";"16.63";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3633675";"";"0";"343.47";"0";"4.05";"3j";"Cc1cc(C2CCCN2C(=O)NCC23CC4CC(CC(C4)C2)C3)no1";"IC50";"'='";"524.3";"nM";"6.28";"";"";"UO_0000065";"18.29";"0.34";"2.23";"10.76";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3633678";"";"0";"343.47";"0";"4.05";"3m";"Cc1cc(C2CCCN2C(=O)NCC23CC4CC(CC(C4)C2)C3)on1";"IC50";"'='";"91.0";"nM";"7.04";"";"";"UO_0000065";"20.50";"0.38";"2.99";"12.06";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL219132";"";"0";"566.70";"2";"3.42";"Table 3,r16c1";"O=C(CCCCCNC(=O)NC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O";"IC50";"'='";"230.0";"nM";"6.64";"";"";"UO_0000065";"11.71";"0.22";"3.22";"4.23";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL3634701";"";"0";"596.54";"3";"-2.03";"14";"COc1cc(O[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)c2c(O)c3c(=O)oc(C)cc3cc2c1";"Inhibition";"'='";"67.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL564227";"";"0";"436.51";"0";"4.05";"(R)-24";"CS(=O)(=O)c1ccc([C@H](CCNC(=O)c2ccc(C#N)cc2)c2ccc(F)cc2)cc1";"EC50";"'='";"2.8";"nM";"8.55";"";"";"UO_0000065";"19.59";"0.38";"4.50";"9.83";"False";"CHEMBL1058193";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL2021549";"";"0";"427.50";"0";"3.89";"(S)-22";"CS(=O)(=O)c1ccc([C@@H](CCNC(=O)c2ccc(O)cc2)c2ccc(F)cc2)cc1";"IC50";"'='";"6.0";"nM";"8.22";"";"";"UO_0000065";"19.23";"0.37";"4.33";"9.85";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL560537";"";"0";"316.40";"0";"4.03";"1";"O=C(NCCC(c1ccccc1)c1ccccc1)c1cccnc1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"25.77";"0.46";"4.12";"19.42";"True";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL563216";"";"0";"352.38";"0";"4.31";"11";"O=C(NCCC(c1ccc(F)cc1)c1ccc(F)cc1)c1cccnc1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"22.98";"0.43";"3.79";"19.28";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL563527";"";"0";"330.43";"0";"3.96";"5";"O=C(Cc1cccnc1)NCCC(c1ccccc1)c1ccccc1";"IC50";"'='";"31.0";"nM";"7.51";"";"";"UO_0000065";"22.72";"0.41";"3.55";"17.88";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL563465";"";"0";"302.38";"0";"3.64";"2";"O=C(NCC(c1ccccc1)c1ccccc1)c1cccnc1";"IC50";"'>'";"3000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1058191";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153540";"1";"Scientific Literature";"J. Med. Chem.";"2009";"None"
"CHEMBL3114607";"";"0";"394.47";"0";"3.42";"36";"O=C(O)Cc1ccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)cc1";"IC50";"'='";"43.2";"nM";"7.37";"";"";"UO_0000065";"18.67";"0.35";"3.94";"9.34";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114604";"";"0";"380.44";"0";"3.49";"33";"O=C(O)c1ccccc1OC1CCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1";"IC50";"'>'";"100.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114594";"";"0";"350.46";"0";"4.10";"16";"Cc1ccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)cc1";"IC50";"'='";"14.2";"nM";"7.85";"";"";"UO_0000065";"22.39";"0.41";"3.75";"18.88";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114615";"";"0";"338.41";"0";"2.59";"8";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ncccn2)CC1";"IC50";"'='";"94.2";"nM";"7.03";"";"";"UO_0000065";"20.76";"0.38";"4.44";"10.43";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114613";"";"0";"337.42";"0";"3.19";"6";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2cccnc2)CC1";"IC50";"'='";"25.2";"nM";"7.60";"";"";"UO_0000065";"22.52";"0.42";"4.41";"13.95";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL1615216";"";"0";"354.45";"0";"3.64";"2";"CC(C)c1noc(C2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)n1";"IC50";"'='";"6.1";"nM";"8.21";"";"";"UO_0000065";"23.18";"0.43";"4.57";"11.53";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3763225";"";"0";"418.33";"0";"4.51";"5b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccccc2Br)cc1";"IC50";"'='";"4000.0";"nM";"5.40";"";"";"UO_0000065";"12.90";"0.28";"0.89";"9.74";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764123";"";"0";"373.88";"0";"4.40";"11b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccc(Cl)cc2)cc1";"IC50";"'='";"1700.0";"nM";"5.77";"";"";"UO_0000065";"15.43";"0.30";"1.37";"10.41";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3633683";"";"0";"397.49";"1";"5.03";"4g";"CC12CC3CC(C)(C1)CC(NC(=O)NCc1cc(-c4cccc(F)c4)no1)(C3)C2";"IC50";"'='";"17.0";"nM";"7.77";"";"";"UO_0000065";"19.55";"0.37";"2.74";"11.57";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3634697";"";"0";"314.29";"0";"2.20";"1; 7-methoxy-obtusifolin";"COc1ccc2c(c1O)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"IC50";"'='";"35700.0";"nM";"4.45";"";"";"UO_0000065";"14.15";"0.26";"2.25";"4.78";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL517625";"";"0";"446.41";"0";"-0.34";"11";"COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(C)cc2c1C(=O)c1c(O)cccc1C2=O";"IC50";"'='";"24300.0";"nM";"4.61";"";"";"UO_0000065";"10.34";"0.20";"4.95";"2.83";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3629069";"";"0";"496.59";"1";"6.75";"37";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)Cc2ccc3ccccc3c2)cc1)C(C)(C)C";"IC50";"'='";"3.4";"nM";"8.47";"";"";"UO_0000065";"17.05";"0.33";"1.72";"11.05";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628769";"";"0";"490.63";"1";"6.57";"16";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"5.1";"nM";"8.29";"";"";"UO_0000065";"16.90";"0.33";"1.72";"10.82";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628766";"";"0";"474.58";"1";"5.93";"13";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C1CC1";"IC50";"'='";"21.0";"nM";"7.68";"";"";"UO_0000065";"16.18";"0.32";"1.75";"10.02";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628411";"";"0";"566.72";"2";"8.19";"5";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)c1ccc(C(C)(C)C)cc1";"IC50";"'='";"192.0";"nM";"6.72";"";"";"UO_0000065";"11.85";"0.23";"-1.47";"8.76";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3764848";"";"0";"377.36";"0";"4.51";"1d";"CC/C(=C\c1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1)C(=O)O";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"18.34";"0.35";"2.41";"10.42";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764424";"";"0";"393.41";"0";"4.38";"17b";"CCOC(=O)C(C)Cc1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1";"IC50";"'='";"250.0";"nM";"6.60";"";"";"UO_0000065";"16.78";"0.32";"2.22";"11.92";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL2425004";"";"0";"445.59";"0";"3.05";"8e";"Cc1cc(C2CCN(C(=O)NC3CCCCC3)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"IC50";"'='";"275.0";"nM";"6.56";"";"";"UO_0000065";"14.72";"0.29";"3.51";"5.95";"False";"CHEMBL2427204";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2424998";"";"0";"469.52";"0";"2.76";"7e";"Cc1cc(C2CCN(C(=O)c3ccc([N+](=O)[O-])cc3)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2425001";"";"0";"405.52";"0";"2.13";"8b";"CCCNC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(N)(=O)=O)cc2)CC1";"Inhibition";"'='";"68.61";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2392694";"";"0";"470.50";"0";"4.13";"10d";"CNc1nc(-c2ccccc2)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.13";"0.36";"4.87";"10.84";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3558237";"";"0";"376.56";"0";"4.04";"BDBM62387";"CCCCCNC(=O)NCCCC/C=C\CCCCCCS(=O)(=O)O";"IC50";"'='";"57.0";"nM";"7.24";"";"423465";"UO_0000065";"19.24";"0.40";"3.20";"7.59";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322814";"";"0";"364.54";"0";"3.91";"BDBM50057494";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1nnn[nH]1";"IC50";"'='";"11.0";"nM";"7.96";"";"423474";"UO_0000065";"21.83";"0.42";"4.05";"8.33";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322815";"";"0";"378.57";"0";"4.30";"BDBM50057497";"CCCCCNC(=O)NCCCC/C=C\CCCCCCCc1nnn[nH]1";"IC50";"'='";"32.0";"nM";"7.50";"";"423476";"UO_0000065";"19.80";"0.38";"3.19";"7.84";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL2436591";"";"0";"441.49";"0";"4.87";"39";"CCC(CC)C(=O)N1CCC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)C2)CC1";"IC50";"'='";"0.3";"nM";"9.52";"";"";"UO_0000065";"21.57";"0.42";"4.65";"15.39";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL4125828";"";"0";"372.62";"1";"5.02";"4b";"CC12CC3CC(C)(C1)CC(NC(=S)NC1C4CC5CC(C4)CC1C5)(C3)C2";"IC50";"'='";"152.0";"nM";"6.82";"";"";"UO_0000065";"18.30";"0.36";"1.80";"28.34";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4130292";"";"0";"342.55";"1";"5.36";"1c";"CCC(CC12CC3CC(CC(C3)C1)C2)NC(=S)Nc1ccccc1";"IC50";"'='";"50248.0";"nM";"4.30";"";"";"UO_0000065";"12.55";"0.24";"-1.06";"17.87";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL3677989";"";"0";"419.40";"0";"4.97";"BDBM158500";"N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"301059";"UO_0000065";"22.18";"0.42";"4.33";"11.15";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL1257989";"";"0";"319.36";"0";"1.94";"BDBM50327830";"CCC(=O)N1CCC(NC(=O)Nc2ccc3c(c2)OCO3)CC1";"IC50";"'='";"61.0";"nM";"7.21";"";"377020";"UO_0000065";"22.59";"0.43";"5.27";"9.03";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4127751";"";"0";"332.49";"0";"4.86";"1n";"CC12CC3CC(C)(C1)CC(NC(=S)Nc1ccc(F)cc1)(C3)C2";"IC50";"'='";"551.0";"nM";"6.26";"";"";"UO_0000065";"18.82";"0.37";"1.40";"26.01";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4067723";"";"0";"341.41";"0";"3.62";"20";"COc1cc(C(=O)NCc2ccc(C(=O)O)cc2)ccc1C(C)(C)C";"IC50";"'='";"5040.0";"nM";"5.30";"";"";"UO_0000065";"15.52";"0.29";"1.68";"7.00";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4086468";"";"0";"391.27";"0";"4.35";"16";"O=C(O)c1ccc(CNC(=O)c2ccc(C(F)(F)F)c(C(F)(F)F)c2)cc1";"Inhibition";"'='";"55.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4093640";"";"0";"338.45";"0";"3.62";"39";"CN(C)C(=O)c1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)cc1";"IC50";"'='";"4600.0";"nM";"5.34";"";"";"UO_0000065";"15.77";"0.29";"1.72";"10.80";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL1668939";"";"0";"393.43";"0";"3.03";"14r";"CC(C)S(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"20.04";"0.41";"4.86";"10.04";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL1615212";"";"0";"262.31";"0";"2.84";"1";"N#Cc1ccc(C(=O)N[C@H]2C[C@@H]2c2ccccc2)cc1";"IC50";"'='";"562.34";"nM";"6.25";"";"";"UO_0000065";"23.83";"0.43";"3.41";"11.82";"False";"CHEMBL1680920";"Inhibition of human soluble epoxide hydrolase in cell free system";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL4204496";"";"0";"680.88";"3";"2.65";"25";"CC(=O)O[C@H]([C@H]1C[C@@H](C)[C@H]2[C@@](O)(O1)[C@H](O)[C@@]1(C)[C@@H]3CC[C@H]4C(C)(C)[C@@H](O[C@@H]5OC[C@@H](O)[C@H](O)[C@H]5O)CC[C@@]45C[C@@]35CC[C@]21C)C(C)(C)O";"IC50";"'='";"400.0";"nM";"6.40";"";"";"UO_0000065";"9.40";"0.18";"3.75";"3.65";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4207574";"";"0";"678.86";"3";"2.41";"29";"CC(=O)O[C@H](C[C@@H](C)[C@H]1C(=O)[C@H](O)[C@@]2(C)C3=CC[C@H]4C(C)(C)[C@@H](O[C@@H]5OC[C@@H](O)[C@H](O)[C@H]5O)CC[C@@]45C[C@@]35CC[C@]12C)[C@@H](O)C(C)(C)O";"IC50";"'='";"5200.0";"nM";"5.28";"";"";"UO_0000065";"7.78";"0.15";"2.87";"2.88";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4218633";"";"0";"632.79";"1";"2.38";"4";"C[C@@H]1C[C@]23OCC(C)(O)[C@H]2O[C@@]2(O3)[C@H]1[C@@]1(C)CC[C@@]34C[C@@]35CC[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]2O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4191392";"Mixed inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4286347";"";"0";"643.59";"2";"6.66";"7";"COc1cc(C(=O)NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12";"IC50";"'='";"550.0";"nM";"6.26";"";"";"UO_0000065";"9.73";"0.20";"-0.40";"5.28";"False";"CHEMBL4256761";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by spectrofluorimetry";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL1257405";"";"0";"371.36";"0";"3.11";"BDBM50327846";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C2CC2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"377049";"UO_0000065";"25.31";"0.49";"6.29";"13.30";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL245006";"";"0";"398.42";"0";"3.59";"20c";"O=C(Nc1ccc(C(=O)O)cc1)N[C@H]1CC[C@@H](Oc2cccc(C(=O)O)c2)CC1";"IC50";"'='";"8300.0";"nM";"5.08";"";"";"UO_0000065";"12.75";"0.24";"1.49";"4.07";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL243336";"";"0";"404.50";"0";"4.92";"13e";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2cc(F)cc(F)c2)CC1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"22.25";"0.42";"4.08";"17.87";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL477247";"";"0";"344.41";"0";"3.27";"8";"COC(=O)c1cc(NC(=O)NC23CC4CC(CC(C4)C2)C3)ccc1O";"IC50";"'='";"12.3";"nM";"7.91";"";"";"UO_0000065";"22.97";"0.43";"4.64";"9.02";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031939";"";"0";"290.36";"0";"3.32";"96";"COC(=O)c1ccc(NC(=O)NC2CCCCCC2)cc1";"IC50";"'='";"12.3";"nM";"7.91";"";"";"UO_0000065";"27.24";"0.51";"4.59";"11.73";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031940";"";"0";"388.51";"1";"5.20";"97";"O=C(Nc1ccc(CC(=O)c2ccccc2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"4.7";"nM";"8.33";"";"";"UO_0000065";"21.44";"0.39";"3.13";"14.31";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL4204930";"";"0";"372.40";"0";"4.04";"3";"O=C(Nc1ccc(F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"20.80";"0.39";"3.70";"8.83";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4216616";"";"0";"354.41";"0";"3.90";"2";"O=C(Nc1ccccc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"30.0";"nM";"7.52";"";"";"UO_0000065";"21.23";"0.40";"3.62";"8.58";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4204424";"";"0";"455.48";"1";"6.38";"PF-3845";"O=C(Nc1cccnc1)N1CCC(Cc2cccc(Oc3ccc(C(F)(F)F)cc3)c2)CC1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL192273";"";"0";"333.56";"1";"5.99";"74";"CCCCCCCCCCCC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"159.0";"nM";"6.80";"";"";"UO_0000065";"20.38";"0.39";"0.81";"23.36";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031934";"";"0";"437.51";"1";"5.06";"90";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(C(F)(F)F)cn2)CC1";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"19.99";"0.39";"3.68";"13.83";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031943";"";"0";"456.51";"0";"4.75";"102";"O=C(Nc1ccc(OCCOCCOCC(F)(F)F)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.3";"nM";"8.48";"";"";"UO_0000065";"18.58";"0.36";"3.73";"12.32";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL3402237";"";"0";"242.32";"0";"3.19";"Fragment 6";"OCCCc1ccc(OCc2ccccc2)cc1";"IC50";"'='";"150000.0";"nM";"3.82";"";"";"UO_0000065";"15.78";"0.29";"0.63";"12.98";"False";"CHEMBL3406221";"Inhibition of C-terminal His6-tagged full-length human soluble epoxide hydrolase expressed in Escherichia coli BL21(DE3) cells pre-incubated for 15 mins before addition of PHOME substrate and measured 50 mins after substrate addition by microplate reader based fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400124";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL2070331";"";"0";"320.43";"0";"2.90";"10";"O=C(NC1CCCC(C(=O)O)C1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1160.0";"nM";"5.94";"";"";"UO_0000065";"18.52";"0.35";"3.04";"7.57";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL66319";"";"0";"380.49";"0";"2.53";"30";"CCOC(=O)CCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC90";"'='";"9000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677486";"Tested for 90 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL4109511";"";"0";"455.60";"0";"3.59";"BDBM179763";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)N[C@H](CC(=O)O)C(=O)O";"IC50";"'='";"392.0";"nM";"6.41";"";"326409";"UO_0000065";"14.06";"0.27";"2.82";"4.42";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322818";"";"0";"400.59";"0";"4.05";"23";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC1=NOS(=O)N1";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"19.97";"0.40";"3.95";"8.71";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322821";"";"0";"396.60";"1";"5.44";"26";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1noc(=S)[nH]1";"IC50";"'='";"31.0";"nM";"7.51";"";"";"UO_0000065";"18.93";"0.38";"2.07";"9.05";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322824";"";"0";"446.62";"1";"5.24";"29";"CCCCCNC(=O)NCCCC/C=C\CCOc1cccc2sc(NC(C)=O)nc12";"IC50";"'='";"282.0";"nM";"6.55";"";"";"UO_0000065";"14.67";"0.29";"1.31";"7.09";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL476057";"";"0";"390.48";"0";"5.00";"36";"O=C(Nc1cccc(OC(=O)c2ccccc2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"5.1";"nM";"8.29";"";"";"UO_0000065";"21.24";"0.39";"3.29";"12.30";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL245159";"";"0";"413.56";"0";"3.88";"40";"O=C(Nc1ccc(OCCCN2CCOCC2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"9.4";"nM";"8.03";"";"";"UO_0000065";"19.41";"0.37";"4.15";"12.78";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL243335";"";"0";"386.51";"0";"4.78";"64, 120";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"24.06";"0.45";"4.52";"18.47";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1818384";"";"0";"324.35";"0";"4.05";"66";"O=C(Nc1ccc(F)c(F)c1F)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"28.97";"0.56";"5.35";"22.85";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1818415";"";"0";"300.40";"0";"3.64";"35";"COc1ccc(NC(=O)NC2C3CC4CC(C3)CC2C4)cc1";"IC50";"'='";"14.3";"nM";"7.84";"";"";"UO_0000065";"26.11";"0.49";"4.20";"15.58";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL2392710";"";"0";"424.43";"0";"2.65";"22";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(OC(F)(F)F)cc3)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392706";"";"0";"424.43";"0";"2.65";"18";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3OC(F)(F)F)CC2)n1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"20.08";"0.39";"5.87";"9.24";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2180626";"";"0";"461.44";"0";"4.93";"5h";"CCOC(=O)c1cccn1Cc1cccc(CNC(=O)Nc2ccc(OC(F)(F)F)cc2)c1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL2392709";"";"0";"424.43";"0";"2.65";"21";"CNc1nc(C)nc(N2CCC(C(=O)NCc3cccc(OC(F)(F)F)c3)CC2)n1";"IC50";"'='";"630.0";"nM";"6.20";"";"";"UO_0000065";"14.61";"0.28";"3.55";"6.72";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL4207574";"";"0";"678.86";"3";"2.41";"29";"CC(=O)O[C@H](C[C@@H](C)[C@H]1C(=O)[C@H](O)[C@@]2(C)C3=CC[C@H]4C(C)(C)[C@@H](O[C@@H]5OC[C@@H](O)[C@H](O)[C@H]5O)CC[C@@]45C[C@@]35CC[C@]12C)[C@@H](O)C(C)(C)O";"Inhibition";"'='";"72.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4191389";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate at 100 uM measured for 1 hr by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL2392740";"";"0";"302.42";"0";"3.16";"52";"CCn1nc(NC(=O)NC2C3CC4CC(C3)CC2C4)cc1C";"IC50";"'='";"2463.0";"nM";"5.61";"";"";"UO_0000065";"18.55";"0.35";"2.45";"9.51";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392732";"";"0";"274.37";"0";"2.51";"44";"Cn1cc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cn1";"IC50";"'='";"488.0";"nM";"6.31";"";"";"UO_0000065";"23.00";"0.43";"3.80";"10.71";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392725";"";"0";"304.39";"0";"3.28";"37";"CC(C)c1nnc(NC(=O)NC23CC4CC(CC(C4)C2)C3)o1";"IC50";"'='";"557.0";"nM";"6.25";"";"";"UO_0000065";"20.55";"0.39";"2.97";"7.81";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL3617998";"";"0";"580.54";"3";"-2.94";"7, aloinoside D";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@](O)([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"Ki";"'='";"10400.0";"nM";"4.98";"";"";"UO_0000065";"8.58";"0.17";"7.92";"2.02";"False";"CHEMBL3620671";"Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL387810";"";"0";"360.47";"0";"4.25";"27";"O=C(NCCCCOc1ccc(F)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"3.9";"nM";"8.41";"";"";"UO_0000065";"23.33";"0.44";"4.16";"16.70";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL244002";"";"0";"438.40";"0";"4.80";"20b";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2cccc(C(=O)O)c2)CC1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"21.04";"0.41";"4.42";"9.52";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL243793";"";"0";"438.40";"0";"4.80";"20a";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2cccc(C(=O)O)c2)CC1";"IC50";"'='";"0.9";"nM";"9.05";"";"";"UO_0000065";"20.63";"0.40";"4.25";"9.34";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL376647";"";"0";"418.53";"1";"5.06";"3f";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2c(F)cccc2F)CC1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"20.95";"0.40";"3.71";"17.41";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL242899";"";"0";"461.44";"1";"5.54";"3b";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCc2ccc(Br)cc2)CC1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"19.00";"0.41";"3.23";"17.41";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL2424992";"";"0";"468.54";"0";"3.51";"6e";"Cc1cc(C2CCN(C(=O)c3ccc([N+](=O)[O-])cc3)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2424984";"";"0";"452.58";"0";"4.30";"9h";"Cc1ccc(NC(=O)N2CCC(c3cc(C)nn3-c3ccc(S(C)(=O)=O)cc3)CC2)cc1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2313190";"";"0";"390.48";"0";"3.48";"7-7";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3F)CC2)c(C)c1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"22.94";"0.45";"5.48";"13.48";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3104437";"";"0";"518.49";"1";"3.62";"34";"O=C1Cc2cc(C(=O)N3CCC4(CC3)CN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CCO4)ccc2N1";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"16.87";"0.32";"5.12";"8.73";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3617999";"";"0";"686.62";"3";"-0.01";"8";"O=C1c2cc(CO)cc(O)c2C(=O)c2c1ccc([C@]1([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3cccc(O)c3C(=O)c3c(O)cc(CO)cc31)c2O";"Ki";"'='";"15500.0";"nM";"4.81";"";"";"UO_0000065";"7.00";"0.13";"4.82";"1.83";"False";"CHEMBL3620670";"Non-competitive inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3765618";"";"0";"345.83";"0";"3.92";"4c";"CCC(Cc1ccc(C(=O)NCc2ccccc2Cl)cc1)C(=O)O";"Inhibition";"'='";"20.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3767858";"Inhibition of human recombinant sEH using PHOME as substrate at 10 uM preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3765347";"";"0";"339.44";"0";"3.75";"2b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccccc2)cc1";"IC50";"'='";"8500.0";"nM";"5.07";"";"";"UO_0000065";"14.94";"0.28";"1.32";"9.15";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3763509";"";"0";"369.46";"0";"3.76";"10b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccc(OC)cc2)cc1";"IC50";"'='";"620.0";"nM";"6.21";"";"";"UO_0000065";"16.80";"0.31";"2.45";"9.60";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL2313168";"";"0";"406.94";"0";"4.00";"7-30";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3Cl)CC2)c(C)c1";"IC50";"'='";"8.7";"nM";"8.06";"";"";"UO_0000065";"19.81";"0.41";"4.06";"12.12";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313196";"";"0";"455.62";"0";"4.33";"7-13";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(N4CCCCC4)cc3)CC2)c(C)c1";"IC50";"'='";"20.0";"nM";"7.70";"";"";"UO_0000065";"16.90";"0.33";"3.37";"11.04";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313194";"";"0";"430.53";"0";"3.13";"7-11";"COC(=O)c1ccc(NC(=O)C2CCN(S(=O)(=O)c3ccc(C)cc3C)CC2)cc1";"IC50";"'='";"8.5";"nM";"8.07";"";"";"UO_0000065";"18.75";"0.37";"4.94";"8.70";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2336305";"";"0";"611.67";"2";"7.55";"8c";"COc1cc(-c2nc3ccc(C)cn3c2NC2CCCCC2)ccc1OCCCNC(=O)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"63.0";"nM";"7.20";"";"";"UO_0000065";"11.77";"0.22";"-0.35";"7.34";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL3629063";"";"0";"486.59";"1";"6.16";"31";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C2CCc3ccccc3C2)cc1)C(C)(C)C";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"17.52";"0.34";"2.36";"11.12";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628783";"";"0";"516.50";"2";"6.57";"30";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)c2ccc(OC(F)(F)F)cc2)cc1)C(C)(C)C";"IC50";"'='";"24.0";"nM";"7.62";"";"";"UO_0000065";"14.75";"0.30";"1.05";"8.87";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL4205926";"";"0";"452.43";"0";"4.88";"22";"COC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"18.02";"0.35";"3.27";"9.49";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL184238";"URB-597";"1";"338.41";"0";"3.87";"URB597";"NC(=O)c1cccc(-c2cccc(OC(=O)NC3CCCCC3)c2)c1";"FC";"'='";"3.0";"";"";"";"";"";"";"";"";"";"False";"CHEMBL4187628";"Time dependent inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction pre-incubated for 10 to 70 mins before CMNPC substrate addition by fluorescence based assay relative to untreated control";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL556487";"";"0";"389.46";"0";"3.58";"2f";"O=C(NC1CC1c1ccccc1)N1CCC(c2nc(-c3ccncc3)no2)CC1";"IC50";"'='";"30.0";"nM";"7.52";"";"";"UO_0000065";"19.32";"0.35";"3.94";"8.94";"False";"CHEMBL1051704";"Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acid";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152451";"1";"Scientific Literature";"J. Med. Chem.";"2009";"CHEMBL3307715"
"CHEMBL1336";"SORAFENIB";"4";"464.83";"1";"5.55";"BDBM16673";"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1";"IC50";"'='";"12.0";"nM";"7.92";"";"301030";"UO_0000065";"17.04";"0.34";"2.37";"8.58";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3946854";"";"0";"388.85";"0";"4.55";"BDBM158482";"O=C(Nc1ccc(Cl)cc1)NC1CCC(Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"5.5";"nM";"8.26";"";"301036";"UO_0000065";"21.24";"0.42";"3.71";"9.42";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3922552";"";"0";"437.85";"1";"5.74";"BDBM158483";"N#Cc1ccc(OC2CCC(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)cc1";"IC50";"'='";"14.6";"nM";"7.84";"";"301037";"UO_0000065";"17.90";"0.36";"2.10";"10.57";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3629070";"";"0";"491.61";"1";"7.00";"38";"CCOP(=O)(OCC)C(Nc1ccc(COC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'>'";"1000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3629068";"";"0";"504.65";"2";"6.96";"36";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)CC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"1.9";"nM";"8.72";"";"";"UO_0000065";"17.28";"0.34";"1.76";"11.38";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3617996";"";"0";"564.54";"3";"-2.04";"5";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@H]([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"IC50";"'='";"20200.0";"nM";"4.70";"";"";"UO_0000065";"8.32";"0.16";"6.73";"2.07";"False";"CHEMBL3620669";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3617996";"";"0";"564.54";"3";"-2.04";"5";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@H]([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"Inhibition";"'='";"86.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3620668";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde at 100 uM measured during 1 hr by fluorescence photometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL1258220";"";"0";"291.35";"0";"1.91";"BDBM50327835";"CCC(=O)N1CCC(NC(=O)Nc2ccc(O)cc2)CC1";"IC50";"'='";"15.0";"nM";"7.82";"";"377026";"UO_0000065";"26.85";"0.51";"5.91";"9.58";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257634";"";"0";"381.38";"0";"2.13";"BDBM25745";"CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"2.9";"nM";"8.54";"";"377052";"UO_0000065";"22.39";"0.47";"6.41";"9.73";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257880";"";"0";"536.58";"1";"4.78";"BDBM50327856";"CN(C)c1cccc2c(S(=O)(=O)N3CCC(NC(=O)Nc4ccc(OC(F)(F)F)cc4)CC3)cccc12";"IC50";"'='";"0.8";"nM";"9.10";"";"377056";"UO_0000065";"16.95";"0.34";"4.32";"10.00";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL2397139";"";"0";"425.57";"0";"4.00";"BDBM50436435";"CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"301039";"UO_0000065";"21.86";"0.41";"5.30";"11.71";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL2313197";"";"0";"457.60";"0";"3.18";"7-14";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(N4CCOCC4)cc3)CC2)c(C)c1";"IC50";"'='";"250.0";"nM";"6.60";"";"";"UO_0000065";"14.43";"0.28";"3.42";"8.36";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL4096637";"";"0";"325.41";"0";"3.54";"23";"CC(C)(C)c1ccc(C(=O)NCc2ccc(CC(=O)O)cc2)cc1";"IC50";"'='";"20000.0";"nM";"4.70";"";"";"UO_0000065";"14.44";"0.27";"1.16";"7.08";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4069036";"";"0";"325.41";"0";"4.17";"32";"CC(NC(=O)c1ccc(C(C)(C)C)cc1)c1ccc(C(=O)O)cc1";"Inhibition";"'='";"37.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL566315";"OBETICHOLIC ACID";"4";"420.63";"1";"5.11";"1a; OCA; 6alpha-ethyl-CDCA";"CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O";"Inhibition";"'='";"29.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019482";"Inhibition of sEH in human HepG2 cells assessed as NF-kappaB mRNA expression at 1 uM after 8 to 16 hrs by SYBR green based qRT-PCR analysis relative to DMSO control";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL1258449";"";"0";"309.80";"0";"2.86";"BDBM50327815";"CCC(=O)N1CCC(NC(=O)Nc2cccc(Cl)c2)CC1";"IC50";"'='";"21.0";"nM";"7.68";"";"377033";"UO_0000065";"24.78";"0.50";"4.82";"12.50";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL2348400";"";"0";"313.26";"0";"-1.70";"6a";"O=c1[nH]c2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cccc2o1";"Inhibition";"'='";"45.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348394";"";"0";"336.28";"0";"1.80";"5e";"O=c1[nH]c2c(OS(=O)(=O)c3ccccc3[N+](=O)[O-])cccc2o1";"Inhibition";"'='";"36.13";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348395";"";"0";"336.28";"0";"1.80";"5f";"O=c1[nH]c2c(OS(=O)(=O)c3cccc([N+](=O)[O-])c3)cccc2o1";"Inhibition";"'='";"31.61";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348396";"";"0";"336.28";"0";"1.80";"5g";"O=c1[nH]c2c(OS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cccc2o1";"Inhibition";"'='";"28.82";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3327067";"";"0";"371.40";"0";"3.86";"7";"CC[C@H](C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"T1/2";"'='";"0.3717";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327068";"";"0";"371.40";"0";"3.86";"8";"CC(C)CC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"0.49";"nM";"9.31";"";"";"UO_0000065";"25.07";"0.49";"5.45";"15.15";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327066";"";"0";"371.40";"0";"3.86";"6";"CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"0.37";"nM";"9.43";"";"";"UO_0000065";"25.40";"0.50";"5.57";"15.35";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL568445";"";"0";"304.27";"1";"5.10";"6a";"FC(F)(F)c1ccc(Nc2cc(-c3ccccc3)on2)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL430175";"";"0";"251.29";"0";"3.40";"6i";"c1ccc(Cc2nnc(Nc3ccccc3)o2)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL568223";"";"0";"294.30";"1";"5.06";"7b";"FC(F)(F)c1ccc(Nc2nsc3ccccc23)cc1";"IC50";"'='";"2500.0";"nM";"5.60";"";"";"UO_0000065";"19.04";"0.38";"0.54";"22.48";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2397148";"";"0";"438.40";"0";"4.80";"t-TUCB";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"T1/2";"'='";"0.2683";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1257518";"";"0";"455.39";"0";"3.13";"BDBM50327852";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2cc(O)c(O)c(O)c2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"377051";"UO_0000065";"20.42";"0.40";"6.17";"7.08";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3765559";"";"0";"399.37";"1";"5.00";"24";"O=C(O)c1ccc(-c2ccc(C(=O)NCc3ccccc3C(F)(F)F)cc2)cc1";"IC50";"'='";"170.0";"nM";"6.77";"";"";"UO_0000065";"16.95";"0.32";"1.77";"10.20";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL2436571";"";"0";"468.33";"1";"5.43";"19";"O=C(Nc1ccc(Cl)cc1Cl)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"115.0";"nM";"6.94";"";"";"UO_0000065";"14.82";"0.31";"1.51";"13.18";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436568";"";"0";"501.88";"2";"5.80";"16";"O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"17.85";"0.36";"3.16";"17.02";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3327080";"";"0";"386.41";"0";"4.20";"23";"CC[C@H](C)C(=O)N1CCC(CC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"Ki";"'='";"11.2";"nM";"7.95";"";"";"UO_0000065";"20.58";"0.40";"3.75";"13.56";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3263290";"";"0";"526.81";"2";"6.36";"1d";"O=C(NCCCCCCCCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"7.3";"nM";"8.14";"";"";"UO_0000065";"15.45";"0.29";"1.78";"9.89";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263293";"";"0";"442.65";"0";"4.30";"2a";"O=C(NCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"7.2";"nM";"8.14";"";"";"UO_0000065";"18.40";"0.35";"3.84";"9.90";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1632454";"";"0";"426.61";"0";"3.79";"16a";"CN1CCN(CCCOc2ccccc2NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"2880.0";"nM";"5.54";"";"";"UO_0000065";"12.99";"0.24";"1.75";"9.75";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL2398220";"";"0";"211.26";"0";"2.87";"4";"O=C(Cc1ccccc1)Nc1ccccc1";"IC50";"'='";"11000.0";"nM";"4.96";"";"";"UO_0000065";"23.47";"0.42";"2.09";"17.04";"False";"CHEMBL2400592";"Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonate) as substrate preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1818410";"";"0";"346.71";"0";"4.82";"30";"O=C(NCc1cccc(Cl)c1)Nc1cccc(C(F)(F)F)c1F";"IC50";"'='";"3.7";"nM";"8.43";"";"";"UO_0000065";"24.32";"0.50";"3.61";"20.50";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL3809056";"";"0";"332.45";"0";"4.83";"8f(S)";"C[C@H](NC(=O)NCCCc1ccccc1)c1cccc2ccccc12";"IC50";"'='";"43.0";"nM";"7.37";"";"";"UO_0000065";"22.16";"0.40";"2.54";"17.91";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3263303";"";"0";"328.50";"0";"4.22";"DAU";"O=C(NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"27.16";"0.51";"4.70";"21.69";"True";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3222121";"";"0";"563.74";"2";"5.65";"5c";"CC(C)(C)OC(=O)N1CCN(CCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c3cccnc23)CC1";"IC50";"'='";"6.8";"nM";"8.17";"";"";"UO_0000065";"14.49";"0.27";"2.52";"8.51";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3819535";"";"0";"601.14";"2";"6.68";"8a";"CCCCCCC(Sc1nc(Cl)cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1)C(=O)OCC";"IC50";"'='";"2500.0";"nM";"5.60";"";"";"UO_0000065";"9.32";"0.19";"-1.08";"6.64";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL3401638";"";"0";"413.54";"0";"2.66";"18";"CS(=O)(=O)N[C@@H]1CCCN(C(=O)N[C@H]2[C@H](c3ccccc3)[C@@H]2c2ccccc2)C1";"IC50";"'='";"1.4";"nM";"8.85";"";"";"UO_0000065";"21.41";"0.42";"6.19";"11.28";"False";"CHEMBL3406976";"Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400076";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3401633";"";"0";"422.53";"0";"4.06";"13";"C[C@@H]1[C@H](NC(=O)N2CCC(Oc3ccc(CCC(=O)O)cc3)CC2)[C@H]1c1ccccc1";"IC50";"'='";"75.7";"nM";"7.12";"";"";"UO_0000065";"16.85";"0.31";"3.06";"9.03";"False";"CHEMBL3406976";"Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400076";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3808508";"";"0";"308.43";"0";"4.00";"8h(R)";"O=C(NCCCc1ccccc1)N[C@@H]1CCCc2ccccc21";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"25.57";"0.47";"3.89";"19.17";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3819103";"";"0";"488.55";"1";"5.59";"5a";"CCOC(=O)/C(=C/c1ccc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)cc1)CC";"IC50";"'='";"40.0";"nM";"7.40";"";"";"UO_0000065";"15.14";"0.29";"1.81";"12.62";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL2425000";"";"0";"391.50";"0";"1.74";"8a";"CCNC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(N)(=O)=O)cc2)CC1";"Inhibition";"'='";"23.31";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL461085";"CHRYSOOBTUSIN";"0";"358.35";"0";"2.51";"3";"COc1cc2c(c(OC)c1OC)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"Inhibition";"'='";"59.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL2031797";"";"0";"396.27";"0";"4.38";"2";"O=C(Nc1ccc(I)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"23.47";"0.60";"4.92";"22.61";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL242459";"";"0";"412.53";"0";"4.34";"123";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"1.5";"nM";"8.82";"";"";"UO_0000065";"21.39";"0.40";"4.48";"10.07";"True";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL153057";"";"0";"402.44";"0";"3.86";"L-165041";"CCCc1c(OCCCOc2ccc(OCC(=O)O)cc2)ccc(C(C)=O)c1O";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL2436588";"";"0";"425.45";"0";"4.09";"36";"CC1CC1C(=O)N1CCC2(CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)C2)CC1";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"20.89";"0.40";"4.80";"14.36";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2336302";"";"0";"533.72";"2";"6.46";"8t";"COc1cc(-c2nc3ccc(C)cn3c2NC2CCCCC2)ccc1OCCCNC(=O)NC1CCCCC1";"IC50";"'='";"242.0";"nM";"6.62";"";"";"UO_0000065";"12.40";"0.23";"0.16";"7.44";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2336306";"";"0";"632.08";"2";"7.90";"8d";"COc1cc(-c2nc3ccc(Cl)cn3c2NC2CCCCC2)ccc1OCCCNC(=O)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"32.0";"nM";"7.50";"";"";"UO_0000065";"11.86";"0.23";"-0.41";"7.64";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2425006";"";"0";"453.57";"0";"2.92";"8g";"Cc1cc(C2CCN(C(=O)NCc3ccccc3)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"Inhibition";"'='";"69.15";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL3103818";"";"0";"400.48";"0";"2.07";"28";"CONC(=O)C(=O)Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"6.6";"nM";"8.18";"";"";"UO_0000065";"20.43";"0.39";"6.11";"7.54";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3103820";"";"0";"414.51";"0";"2.41";"30";"CON(C)C(=O)C(=O)Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"20.03";"0.38";"5.89";"8.32";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3104441";"";"0";"503.52";"1";"4.54";"38";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)C3(c4ccccc4)CC3)CC2)C1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"18.66";"0.36";"4.86";"13.22";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104431";"";"0";"468.43";"0";"3.42";"28";"Cc1cc(C(=O)N2CCC3(CC2)CN(C(=O)Nc2ccc(OC(F)(F)F)cc2)CCO3)no1";"IC50";"'='";"1.4";"nM";"8.85";"";"";"UO_0000065";"18.90";"0.37";"5.43";"9.11";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3103813";"";"0";"399.49";"0";"2.48";"20";"CON(C)C(=O)C(=O)Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"190.0";"nM";"6.72";"";"";"UO_0000065";"16.82";"0.32";"4.24";"7.66";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3103817";"";"0";"413.52";"0";"3.21";"26";"CON(C)C(=O)C(=O)N(C)c1ccc(NC(=O)CC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"4.4";"nM";"8.36";"";"";"UO_0000065";"20.21";"0.38";"5.15";"10.58";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3114606";"";"0";"380.44";"0";"3.49";"35";"O=C(O)c1ccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)cc1";"IC50";"'='";"30.3";"nM";"7.52";"";"";"UO_0000065";"19.76";"0.37";"4.03";"9.53";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114601";"";"0";"412.53";"1";"5.46";"23";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccccc2-c2ccccc2)CC1";"IC50";"'='";"14.7";"nM";"7.83";"";"";"UO_0000065";"18.99";"0.35";"2.37";"18.84";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL2397138";"";"0";"451.45";"0";"4.46";"15";"CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"20.60";"0.40";"4.84";"10.49";"False";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392714";"";"0";"408.43";"0";"2.77";"10a";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"17.14";"0.33";"4.23";"8.43";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392692";"";"0";"503.32";"1";"3.42";"27, GSK2188931B";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(Br)cc3OC(F)(F)F)CC2)n1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"16.93";"0.38";"5.10";"9.24";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392695";"";"0";"422.45";"0";"2.80";"10e";"Cc1nc(N(C)C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"18.45";"0.35";"5.00";"10.50";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392760";"";"0";"275.35";"0";"3.07";"27";"Cc1cc(NC(=O)NC23CC4CC(CC(C4)C2)C3)on1";"IC50";"'='";"117.0";"nM";"6.93";"";"";"UO_0000065";"25.17";"0.47";"3.86";"10.32";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392758";"";"0";"354.25";"0";"3.84";"25";"Cc1onc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1Br";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"25.68";"0.59";"5.26";"13.55";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392744";"";"0";"444.56";"0";"4.18";"10";"Cc1nc(NS(=O)(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)oc1C";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"17.74";"0.35";"3.71";"6.96";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2180635";"";"0";"433.39";"0";"4.45";"6h";"O=C(NCc1cccc(Cn2cccc2C(=O)O)c1)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"943.0";"nM";"6.03";"";"";"UO_0000065";"13.90";"0.27";"1.58";"6.51";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL2397141";"";"0";"470.88";"0";"4.63";"4, t-CUPM";"CNC(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"19.75";"0.40";"4.67";"10.07";"False";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL535";"SUNITINIB";"4";"398.48";"0";"3.33";"Sunitinib";"CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392695";"";"0";"422.45";"0";"2.80";"10e";"Cc1nc(N(C)C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"21.30";"0.41";"6.20";"12.12";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392696";"";"0";"436.48";"0";"3.55";"10f";"Cc1nc(NC(C)C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"20.62";"0.40";"5.45";"10.84";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392715";"";"0";"422.45";"0";"3.03";"10b";"CCc1nc(NC)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"80.0";"nM";"7.10";"";"";"UO_0000065";"16.80";"0.32";"4.07";"8.55";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392718";"";"0";"316.45";"0";"3.55";"53";"CCCn1nc(NC(=O)NC2C3CC4CC(C3)CC2C4)cc1C";"IC50";"'='";"936.0";"nM";"6.03";"";"";"UO_0000065";"19.05";"0.36";"2.48";"10.23";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392690";"";"0";"426.42";"0";"2.91";"25";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(F)cc3C(F)(F)F)CC2)n1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"19.99";"0.39";"5.61";"10.26";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392734";"";"0";"317.43";"0";"3.92";"46";"CC(C)(C)c1cc(NC(=O)NC2C3CC4CC(C3)CC2C4)no1";"IC50";"'='";"73.0";"nM";"7.14";"";"";"UO_0000065";"22.48";"0.42";"3.22";"10.63";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL603";"ZAFIRLUKAST";"4";"575.69";"2";"5.70";"1";"COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12";"IC50";"'='";"2000.0";"nM";"5.70";"";"";"UO_0000065";"9.90";"0.19";"0.00";"4.92";"False";"CHEMBL4256761";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by spectrofluorimetry";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL2348402";"";"0";"322.32";"0";"1.94";"3b";"CC(NC(=O)OC(C)(C)C)C(=O)Oc1cccc2oc(=O)[nH]c12";"IC50";"'='";"16400.0";"nM";"4.79";"";"";"UO_0000065";"14.85";"0.28";"2.85";"4.33";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348405";"";"0";"382.44";"0";"2.67";"3e";"CSCCC(NC(=O)OC(C)(C)C)C(=O)Oc1cccc2oc(=O)[nH]c12";"IC50";"'='";"3020.0";"nM";"5.52";"";"";"UO_0000065";"14.43";"0.29";"2.85";"4.99";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348407";"";"0";"348.36";"0";"2.43";"3g";"CC(C)(C)OC(=O)N1CCCC1C(=O)Oc1cccc2oc(=O)[nH]c12";"IC50";"'='";"1720.0";"nM";"5.76";"";"";"UO_0000065";"16.55";"0.31";"3.33";"5.66";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348389";"";"0";"269.26";"0";"2.65";"4j";"Cc1ccc(C(=O)Oc2cccc3oc(=O)[nH]c23)cc1";"IC50";"'='";"1070.0";"nM";"5.97";"";"";"UO_0000065";"22.17";"0.41";"3.32";"8.26";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1458";"1,3-DICYCLOHEXYLUREA";"0";"224.35";"0";"2.95";"Figure 2, C8";"O=C(NC1CCCCC1)NC1CCCCC1";"IC50";"'='";"25.0";"nM";"7.60";"";"";"UO_0000065";"33.88";"0.65";"4.65";"18.48";"False";"CHEMBL3812616";"Inhibition of sEH (unknown origin)";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808350";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2016";"None"
"CHEMBL42624";"PHYSCION";"0";"284.27";"0";"2.19";"7";"COc1cc(O)c2c(c1)C(=O)c1cc(C)cc(O)c1C2=O";"Inhibition";"'='";"27.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL511524";"";"0";"344.32";"0";"2.21";"4";"COc1cc2c(c(O)c1OC)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"Inhibition";"'='";"55.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL461288";"AURANTIOOBTUSIN";"0";"330.29";"0";"1.90";"2";"COc1c(O)cc2c(c1O)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"Inhibition";"'='";"0.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3222128";"";"0";"277.41";"0";"1.91";"7e";"CN1CCN(C(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"63.7";"nM";"7.20";"";"";"UO_0000065";"25.94";"0.49";"5.29";"20.22";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3222122";"";"0";"445.61";"0";"1.46";"6a";"O=C(NC1CCN(C(=O)CCC(=O)N2CCNCC2)CC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"77.3";"nM";"7.11";"";"";"UO_0000065";"15.96";"0.30";"5.65";"7.58";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3222126";"";"0";"305.42";"0";"1.83";"7b";"CC(=O)N1CCN(C(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"321.0";"nM";"6.49";"";"";"UO_0000065";"21.26";"0.40";"4.66";"12.33";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL442384";"";"0";"218.20";"0";"2.90";"5";"Nc1nc2ccc(C(F)(F)F)cc2s1";"IC50";"'='";"49000.0";"nM";"4.31";"";"";"UO_0000065";"19.75";"0.42";"1.41";"11.08";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL567703";"";"0";"478.49";"0";"4.41";"42";"CS(=O)(=O)c1ccc(-c2ccc(CNC(=O)c3ccc(OCCC(F)(F)F)nc3)cc2)cc1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"16.55";"0.33";"3.51";"9.28";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL567110";"";"0";"408.30";"0";"4.24";"39";"O=C(NCc1ccccc1OC(F)(F)F)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"4.6";"nM";"8.34";"";"";"UO_0000065";"20.42";"0.41";"4.10";"13.79";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL576449";"";"0";"324.30";"0";"3.34";"33";"O=C(NCc1ccccc1)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"18.26";"0.35";"2.58";"11.56";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL566648";"";"0";"487.19";"1";"5.00";"41";"O=C(NCc1ccc(Br)cc1OC(F)(F)F)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"16.26";"0.37";"2.92";"13.10";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL566047";"";"0";"402.39";"0";"2.75";"37";"CS(=O)(=O)c1ccccc1CNC(=O)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"270.0";"nM";"6.57";"";"";"UO_0000065";"16.32";"0.33";"3.82";"7.70";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL567314";"";"0";"383.76";"0";"3.87";"40";"N#Cc1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)c(Cl)c1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"20.64";"0.42";"4.05";"10.56";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL576659";"";"0";"318.30";"0";"4.97";"6b";"FC(F)(F)c1ccc(CNc2cc(-c3ccccc3)on2)cc1";"IC50";"'='";"4700.0";"nM";"5.33";"";"";"UO_0000065";"16.74";"0.32";"0.36";"14.00";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL576254";"";"0";"224.26";"0";"3.44";"7f";"c1ccc(CNc2nc3ccccc3o2)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL568231";"";"0";"405.38";"1";"6.81";"7cc";"FC(F)(F)c1ccc(Nc2noc3cc(-c4cccc5cnccc45)ccc23)cc1";"IC50";"'='";"19.0";"nM";"7.72";"";"";"UO_0000065";"19.05";"0.35";"0.91";"15.15";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL577695";"";"0";"346.23";"1";"5.61";"7t";"FC(F)(F)c1ccc(Nc2noc3c(C(F)(F)F)cccc23)cc1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"17.10";"0.34";"0.31";"15.56";"False";"CHEMBL1044416";"Inhibition of human sEH assessed as DHET production in presence of 10% human serum";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2436561";"";"0";"424.45";"0";"4.00";"9";"N#Cc1ccc(NC(=O)N2CCC3(CCN(C(=O)c4c(F)cccc4F)CC3)C2)cc1";"IC50";"'='";"51.7";"nM";"7.29";"";"";"UO_0000065";"17.17";"0.32";"3.29";"9.53";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3099593";"";"0";"236.28";"0";"1.10";"o";"CCCCNC(=O)Nc1ccc(C(N)=O)cn1";"IC50";"'='";"57000.0";"nM";"4.24";"";"";"UO_0000065";"17.96";"0.34";"3.14";"4.37";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL4282083";"";"0";"242.27";"0";"2.54";"1";"CC1=CC[C@@H]2C(=C(O)c3ccccc3[C@@H]2O)C1=O";"IC50";"'='";"1100.0";"nM";"5.96";"";"";"UO_0000065";"24.59";"0.45";"3.42";"10.36";"False";"CHEMBL4269821";"Inhibition of soluble epoxide hydrolase (unknown origin) using NEPC as substrate after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4266023";"1";"Scientific Literature";"J Nat Prod";"2018";"None"
"CHEMBL441348";"";"0";"347.24";"0";"4.13";"225";"CN(C)C(=O)N(CCCCCC(=O)O)c1ccc(Cl)c(Cl)c1";"IC50";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL810460";"Inhibitory activity against human soluble epoxide hydrolase; N/A = could not be determined because of above the highest concentration (500 uM) of inhibitor tested.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1136721";"1";"Scientific Literature";"J. Med. Chem.";"2003";"None"
"CHEMBL476668";"";"0";"328.41";"0";"3.56";"10, 79";"COC(=O)c1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"13.5";"nM";"7.87";"";"";"UO_0000065";"23.96";"0.45";"4.31";"11.67";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2424982";"";"0";"438.55";"0";"4.00";"9f";"Cc1cc(C2CCN(C(=O)Nc3ccccc3)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"IC50";"'='";"220.0";"nM";"6.66";"";"";"UO_0000065";"15.18";"0.29";"2.66";"7.90";"False";"CHEMBL2427204";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2424990";"";"0";"457.98";"0";"4.26";"6b";"Cc1cc(C2CCN(C(=O)c3ccc(Cl)cc3)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2425002";"";"0";"405.52";"0";"2.13";"8c";"Cc1cc(C2CCN(C(=O)NC(C)C)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"IC50";"'='";"22256.0";"nM";"4.65";"";"";"UO_0000065";"11.47";"0.23";"2.52";"4.22";"False";"CHEMBL2427204";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL1271608";"";"0";"409.37";"0";"4.60";"15";"O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cn1)c1ccccc1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"20.28";"0.38";"3.70";"11.42";"False";"CHEMBL1273200";"Displacement of [3H]-cDPPO from human Ephx2 by cell-based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1258904";"";"0";"359.35";"0";"3.11";"18, TPPU";"CCC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"T1/2";"'='";"0.1833";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1668936";"";"0";"365.38";"0";"2.25";"25";"CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"7.16";"nM";"8.14";"";"";"UO_0000065";"22.29";"0.46";"5.90";"10.37";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327087";"";"0";"423.46";"0";"3.30";"32";"CCCCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"Ki";"'='";"0.44";"nM";"9.36";"";"";"UO_0000065";"22.10";"0.46";"6.06";"10.66";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL469360";"";"0";"502.99";"2";"5.00";"8-33";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3cc(C(F)(F)F)ccc3Cl)CC2)c(C)c1";"Inhibition";"'='";"94.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469792";"";"0";"406.59";"0";"3.85";"8-42";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCCCC3)CC2)c(C)c1";"Inhibition";"'='";"90.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3634700";"";"0";"556.52";"3";"-1.94";"13";"COc1cc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2c(OC)c(C(C)=O)c(O[C@H]3OC[C@@](O)(CO)[C@@H]3O)cc2c1";"Inhibition";"'='";"91.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3263294";"";"0";"498.76";"1";"5.57";"2b";"CC(NC(=O)NCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"17.89";"0.34";"3.35";"10.84";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3824249";"";"0";"460.32";"1";"6.00";"8h";"CCC(=O)Nc1cc(Cl)c(Oc2ccc(O)c(-c3ccc(NC(N)=O)cc3)c2)c(Cl)c1";"IC50";"'='";"7500.0";"nM";"5.12";"";"";"UO_0000065";"11.13";"0.23";"-0.88";"4.51";"False";"CHEMBL3825936";"Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured after 10 mins by liquid scintillation counter method";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"BTI-TN-5B1-4";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3822419";"1";"Scientific Literature";"J. Med. Chem.";"2016";"CHEMBL3833782"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"Table4, R12";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"19.86";"0.38";"2.56";"9.94";"False";"CHEMBL3825936";"Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured after 10 mins by liquid scintillation counter method";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"BTI-TN-5B1-4";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3822419";"1";"Scientific Literature";"J. Med. Chem.";"2016";"CHEMBL3833782"
"CHEMBL3819337";"";"0";"376.84";"0";"3.99";"3a";"CCOC(=O)C(C)Oc1ccc(CNC(=O)Nc2ccc(Cl)cc2)cc1";"IC50";"'='";"64.0";"nM";"7.19";"";"";"UO_0000065";"19.09";"0.38";"3.20";"9.38";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"107.0";"nM";"6.97";"Potential transcription error";"";"UO_0000065";"";"";"";"";"True";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL470614";"";"0";"449.02";"0";"4.02";"8-29";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCCc3cccc(Cl)c3)CC2)c(C)c1";"IC50";"'='";"64.0";"nM";"7.19";"";"";"UO_0000065";"16.02";"0.33";"3.17";"10.82";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472629";"";"0";"352.50";"0";"2.54";"8-12";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC(C)C)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL513751";"";"0";"401.53";"0";"2.72";"8-18";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3cccnc3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512659";"";"0";"452.98";"0";"4.12";"8-36";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(F)cc3Cl)CC2)c(C)c1";"IC50";"'='";"54.1";"nM";"7.27";"";"";"UO_0000065";"16.04";"0.33";"3.15";"10.93";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469999";"";"0";"414.57";"0";"3.37";"8-21";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCCc3ccccc3)CC2)c(C)c1";"IC50";"'='";"43.3";"nM";"7.36";"";"";"UO_0000065";"17.76";"0.35";"3.99";"11.08";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469579";"";"0";"493.67";"0";"3.53";"8-44";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCN(C(=O)OC(C)(C)C)CC3)CC2)c(C)c1";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"16.12";"0.32";"4.43";"8.29";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL470837";"";"0";"378.54";"0";"3.07";"8-48";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC3CCCC3)CC2)c(C)c1";"IC50";"'='";"37.3";"nM";"7.43";"";"";"UO_0000065";"19.62";"0.39";"4.36";"11.17";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2392689";"";"0";"365.44";"0";"1.63";"24";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3C#N)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392752";"";"0";"273.34";"0";"1.96";"19";"O=C(Nc1ncncn1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"79.0";"nM";"7.10";"";"";"UO_0000065";"25.98";"0.48";"5.14";"8.90";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392747";"";"0";"440.57";"0";"4.16";"13";"Nc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)cc1";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"20.78";"0.40";"4.99";"8.08";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392742";"";"0";"457.56";"0";"3.38";"8";"COc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)nn1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"17.82";"0.35";"4.77";"6.67";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2348402";"";"0";"322.32";"0";"1.94";"3b";"CC(NC(=O)OC(C)(C)C)C(=O)Oc1cccc2oc(=O)[nH]c12";"Inhibition";"'='";"95.73";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348401";"";"0";"308.29";"0";"1.55";"3a";"CC(C)(C)OC(=O)NCC(=O)Oc1cccc2oc(=O)[nH]c12";"Inhibition";"'='";"95.46";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348193";"";"0";"300.23";"0";"2.25";"4g";"O=C(Oc1cccc2oc(=O)[nH]c12)c1ccc([N+](=O)[O-])cc1";"Inhibition";"'='";"28.08";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348189";"";"0";"289.67";"0";"2.99";"4c";"O=C(Oc1cccc2oc(=O)[nH]c12)c1cccc(Cl)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348408";"";"0";"255.23";"0";"2.34";"4a";"O=C(Oc1cccc2oc(=O)[nH]c12)c1ccccc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2397140";"";"0";"469.89";"1";"5.23";"13";"CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"19.79";"0.40";"4.07";"11.71";"False";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL4129280";"";"0";"448.72";"1";"7.19";"3f";"CC12CC3CC(C)(C1)CC(NC(=S)Nc1ccc(C45CC6CC(CC(C6)C4)C5)cc1)(C3)C2";"IC50";"'='";"2479.0";"nM";"5.61";"";"";"UO_0000065";"12.49";"0.24";"-1.58";"23.30";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4098527";"";"0";"344.38";"0";"3.06";"26";"CCN1CCC(C(=O)NCc2ccc(OC)cc2C(F)(F)F)CC1";"IC50";"'='";"109.0";"nM";"6.96";"";"";"UO_0000065";"20.22";"0.40";"3.90";"16.75";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL242459";"";"0";"412.53";"0";"4.34";"11, t-AUCB";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"1.5";"nM";"8.82";"";"";"UO_0000065";"21.39";"0.40";"4.48";"10.07";"True";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1818414";"";"0";"352.40";"0";"4.42";"34";"CN(C(=O)N(C)C1C2CC3CC(C2)CC1C3)c1ccc(F)c(F)c1F";"IC50";"'='";"1838.1";"nM";"5.74";"";"";"UO_0000065";"16.28";"0.31";"1.32";"24.36";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL2336301";"";"0";"585.79";"2";"7.10";"8s";"COc1cc(-c2nc3ccc(C)cn3c2NC2CCCCC2)ccc1OCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"11.95";"0.22";"-0.10";"7.87";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2336303";"";"0";"562.11";"2";"7.31";"8a";"COc1cc(-c2nc3ccc(C)cn3c2NC2CCCCC2)ccc1OCCCNC(=O)Nc1ccc(Cl)cc1";"IC50";"'='";"70.0";"nM";"7.16";"";"";"UO_0000065";"12.73";"0.24";"-0.16";"8.05";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL1668930";"";"0";"295.43";"0";"2.27";"14i";"CC(=O)N1CCC(NC(=O)NC2CCC(C)(C)CC2)CC1";"IC50";"'='";"38.0";"nM";"7.42";"";"";"UO_0000065";"25.12";"0.48";"5.15";"12.08";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL1668932";"";"0";"329.32";"0";"2.84";"14k";"CC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"24.17";"0.47";"5.12";"12.95";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1632459";"";"0";"426.61";"0";"3.79";"16c";"CN1CCN(CCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1";"IC50";"'='";"17.9";"nM";"7.75";"";"";"UO_0000065";"18.16";"0.34";"3.96";"13.63";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632486";"";"0";"598.71";"2";"6.41";"42";"O=C(Nc1cccc(OCCCCN2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"13.6";"nM";"7.87";"";"";"UO_0000065";"13.14";"0.25";"1.46";"10.64";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632490";"";"0";"512.70";"2";"5.10";"20c";"CC(C)(C)OC(=O)N1CCN(CCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1";"IC50";"'='";"14.6";"nM";"7.84";"";"";"UO_0000065";"15.28";"0.29";"2.74";"9.42";"True";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL2392761";"";"0";"329.32";"0";"3.78";"28";"O=C(Nc1cc(C(F)(F)F)no1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"26.41";"0.52";"4.92";"12.95";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2425002";"";"0";"405.52";"0";"2.13";"8c";"Cc1cc(C2CCN(C(=O)NC(C)C)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"Inhibition";"'='";"104.86";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL4126795";"";"0";"332.49";"0";"4.72";"1l";"CC(NC(=S)Nc1cccc(F)c1)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"451.0";"nM";"6.35";"";"";"UO_0000065";"19.09";"0.38";"1.63";"26.37";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4129077";"";"0";"314.50";"0";"4.72";"1a";"CC12CC3CC(C)(C1)CC(NC(=S)Nc1ccccc1)(C3)C2";"IC50";"'='";"1224.0";"nM";"5.91";"";"";"UO_0000065";"18.80";"0.37";"1.19";"24.57";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL242256";"";"0";"306.45";"0";"3.21";"128";"CO[C@H]1CC[C@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"2.7";"nM";"8.57";"";"";"UO_0000065";"27.96";"0.53";"5.36";"17.01";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031802";"";"0";"386.39";"1";"5.01";"11";"O=C(Nc1cccc(OC(F)(F)C(F)F)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.5";"nM";"8.82";"";"";"UO_0000065";"22.84";"0.45";"3.81";"17.52";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031803";"";"0";"316.47";"0";"4.50";"12, 81";"CSc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"27.79";"0.55";"4.30";"21.39";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031804";"";"0";"312.41";"0";"3.98";"14";"CC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"6.3";"nM";"8.20";"";"";"UO_0000065";"26.25";"0.49";"4.22";"14.09";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031812";"";"0";"362.47";"1";"5.57";"32";"O=C(Nc1ccc(Oc2ccccc2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"25.66";"0.47";"3.73";"18.47";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031814";"";"0";"374.48";"1";"5.01";"35";"O=C(Nc1ccc(C(=O)c2ccccc2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"23.49";"0.43";"3.79";"15.11";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031816";"";"0";"362.47";"1";"5.57";"38";"O=C(Nc1cccc(Oc2ccccc2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.9";"nM";"9.05";"";"";"UO_0000065";"24.96";"0.46";"3.48";"17.96";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL10835";"";"0";"350.03";"1";"5.94";"68";"O=C(Nc1ccc(Cl)c(Cl)c1)Nc1ccc(Cl)c(Cl)c1";"IC50";"'='";"28.1";"nM";"7.55";"";"";"UO_0000065";"21.57";"0.52";"1.61";"18.36";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL396760";"";"0";"402.54";"0";"4.21";"76";"CCOCCOCCOc1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"22.26";"0.42";"4.75";"13.02";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031933";"";"0";"440.58";"0";"4.47";"89";"COCC(=O)c1ccc(O[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1";"IC50";"'='";"3.8";"nM";"8.42";"";"";"UO_0000065";"19.11";"0.36";"3.95";"10.98";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031938";"";"0";"405.40";"0";"4.52";"95";"O=C(Nc1cccc([N+](=O)[O-])c1)N[C@H]1CC[C@H](OCc2c(F)cccc2F)CC1";"IC50";"'='";"90.0";"nM";"7.05";"";"";"UO_0000065";"17.38";"0.33";"2.53";"7.54";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1552108";"";"0";"438.40";"0";"4.80";"BDBM158480";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"0.6";"nM";"9.22";"";"301034";"UO_0000065";"21.04";"0.41";"4.42";"9.52";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3677983";"";"0";"513.94";"2";"6.22";"BDBM158492";"CC(C)(C)OC(=O)c1cc(O[C@H]2CC[C@@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"301049";"UO_0000065";"18.10";"0.36";"3.08";"10.39";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322809";"";"0";"382.58";"0";"4.07";"BDBM50057480";"CCCCCNC(=O)NCCCC/C=C\CCCCCSc1nnn[nH]1";"IC50";"'='";"22.0";"nM";"7.66";"";"326388";"UO_0000065";"20.02";"0.40";"3.59";"8.01";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3222116";"";"0";"460.60";"0";"2.49";"3d";"CS(=O)(=O)N1CCN(C(=O)c2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"41.8";"nM";"7.38";"";"";"UO_0000065";"16.02";"0.31";"4.89";"7.47";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3222113";"";"0";"382.51";"0";"2.82";"3a";"O=C(Nc1cccc(C(=O)N2CCNCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"133.4";"nM";"6.88";"";"";"UO_0000065";"17.97";"0.34";"4.05";"9.36";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3222123";"";"0";"487.65";"0";"1.72";"6b";"CC(=O)N1CCN(C(=O)CCC(=O)N2CCC(NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)CC1";"IC50";"'='";"44.7";"nM";"7.35";"";"";"UO_0000065";"15.07";"0.29";"5.63";"7.20";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL214920";"TIOCARLIDE";"0";"400.59";"1";"6.35";"43, Isoxyl";"CC(C)CCOc1ccc(NC(=S)Nc2ccc(OCCC(C)C)cc2)cc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818417";"";"0";"266.38";"0";"2.29";"38";"COCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"386.1";"nM";"6.41";"";"";"UO_0000065";"24.08";"0.46";"4.12";"12.73";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1609005";"";"0";"276.42";"0";"3.44";"18";"O=C(NC1CCCCC1)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"34.00";"0.64";"5.96";"22.85";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818399";"";"0";"236.36";"0";"2.52";"17";"CCCNC(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"61.4";"nM";"7.21";"";"";"UO_0000065";"30.51";"0.58";"4.69";"17.53";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818397";"";"0";"318.85";"0";"4.59";"14";"Cc1c(Cl)cccc1NC(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"4.5";"nM";"8.35";"";"";"UO_0000065";"26.18";"0.52";"3.76";"20.29";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL3628779";"";"0";"561.75";"2";"8.07";"26";"CCCCOP(=O)(OCCCC)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"15.17";"0.30";"0.45";"9.61";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628415";"";"0";"535.63";"2";"6.77";"9";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)c1ccc(C#N)cc1";"IC50";"'='";"108.0";"nM";"6.97";"";"";"UO_0000065";"13.01";"0.25";"0.20";"6.94";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3634697";"";"0";"314.29";"0";"2.20";"1; 7-methoxy-obtusifolin";"COc1ccc2c(c1O)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"Inhibition";"'='";"54.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL517625";"";"0";"446.41";"0";"-0.34";"11";"COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(C)cc2c1C(=O)c1c(O)cccc1C2=O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL289277";"EMODIN";"0";"270.24";"0";"1.89";"6";"Cc1cc(O)c2c(c1)C(=O)c1cc(O)cc(O)c1C2=O";"IC50";"'='";"36400.0";"nM";"4.44";"";"";"UO_0000065";"16.43";"0.30";"2.55";"4.68";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3634701";"";"0";"596.54";"3";"-2.03";"14";"COc1cc(O[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)c2c(O)c3c(=O)oc(C)cc3cc2c1";"IC50";"'='";"20000.0";"nM";"4.70";"";"";"UO_0000065";"7.88";"0.15";"6.73";"1.97";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3628412";"";"0";"540.64";"2";"6.90";"6";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)c1ccc(OC)cc1";"IC50";"'='";"199.0";"nM";"6.70";"";"";"UO_0000065";"12.39";"0.24";"-0.20";"7.80";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3263300";"";"0";"518.75";"2";"7.14";"4b";"CC(NC(=O)Nc1ccc(NC(=O)NC(C)C23CC4CC(CC(C4)C2)C3)cc1)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"161.0";"nM";"6.79";"";"";"UO_0000065";"13.10";"0.24";"-0.35";"8.26";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL2313202";"";"0";"441.38";"0";"4.65";"7-19";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(Cl)c(Cl)c3)CC2)c(C)c1";"IC50";"'='";"55.0";"nM";"7.26";"";"";"UO_0000065";"16.45";"0.35";"2.61";"10.92";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436573";"";"0";"481.45";"0";"4.59";"21";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3cc(O)ccc3F)CC2)C1";"IC50";"'='";"0.2";"nM";"9.70";"";"";"UO_0000065";"20.15";"0.39";"5.11";"11.81";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL469371";"";"0";"395.53";"0";"1.38";"8-49";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NN3CCOCC3)CC2)c(C)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469546";"";"0";"469.43";"0";"4.64";"1";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccc(Cl)cc3Cl)CC2)c(C)c1";"Inhibition";"'='";"97.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472629";"";"0";"352.50";"0";"2.54";"8-12";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NC(C)C)CC2)c(C)c1";"Inhibition";"'='";"-7.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2336297";"";"0";"611.67";"2";"7.55";"8o";"COc1ccc(-c2nc3ccc(C)cn3c2NC2CCCCC2)cc1OCCCNC(=O)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"38.0";"nM";"7.42";"";"";"UO_0000065";"12.13";"0.23";"-0.13";"7.56";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2336310";"";"0";"597.64";"2";"7.16";"8h";"COc1cc(-c2nc3ccc(C)cn3c2NC2CCCC2)ccc1OCCCNC(=O)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"71.0";"nM";"7.15";"";"";"UO_0000065";"11.96";"0.23";"-0.01";"7.28";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2313162";"";"0";"336.46";"0";"1.98";"7-24";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CC3)CC2)c(C)c1";"IC50";"'='";"4.6";"nM";"8.34";"";"";"UO_0000065";"24.78";"0.50";"6.36";"12.54";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1257635";"";"0";"395.40";"0";"2.52";"56";"CCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"23.77";"0.49";"6.88";"10.71";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL2348387";"";"0";"269.26";"0";"2.65";"4h";"Cc1ccccc1C(=O)Oc1cccc2oc(=O)[nH]c12";"Inhibition";"'='";"26.22";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348388";"";"0";"269.26";"0";"2.65";"4i";"Cc1cccc(C(=O)Oc2cccc3oc(=O)[nH]c23)c1";"Inhibition";"'='";"24.44";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348391";"";"0";"325.73";"0";"2.54";"5b";"O=c1[nH]c2c(OS(=O)(=O)c3ccccc3Cl)cccc2o1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348387";"";"0";"269.26";"0";"2.65";"4h";"Cc1ccccc1C(=O)Oc1cccc2oc(=O)[nH]c12";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348188";"";"0";"289.67";"0";"2.99";"4b";"O=C(Oc1cccc2oc(=O)[nH]c12)c1ccccc1Cl";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348192";"";"0";"300.23";"0";"2.25";"4f";"O=C(Oc1cccc2oc(=O)[nH]c12)c1cccc([N+](=O)[O-])c1";"IC50";"'='";"3000.0";"nM";"5.52";"";"";"UO_0000065";"18.40";"0.34";"3.27";"4.78";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2425005";"";"0";"439.54";"0";"3.24";"8f";"Cc1cc(C2CCN(C(=O)Nc3ccccc3)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"IC50";"'='";"16699.0";"nM";"4.78";"";"";"UO_0000065";"10.87";"0.21";"1.54";"4.33";"False";"CHEMBL2427204";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2424999";"";"0";"390.51";"0";"2.33";"7f";"CCCC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(N)(=O)=O)cc2)CC1";"Inhibition";"'='";"68.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2424997";"";"0";"454.55";"0";"2.86";"7d";"COc1ccc(C(=O)N2CCC(c3cc(C)nn3-c3ccc(S(N)(=O)=O)cc3)CC2)cc1";"Inhibition";"'='";"32.89";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2424981";"";"0";"444.60";"0";"3.81";"9e";"Cc1cc(C2CCN(C(=O)NC3CCCCC3)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"Inhibition";"'='";"113.97";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL3917808";"";"0";"513.94";"2";"6.22";"BDBM158489";"CC(C)(C)OC(=O)c1cc(OC2CCC(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1";"IC50";"'='";"0.9";"nM";"9.05";"";"301044";"UO_0000065";"17.60";"0.35";"2.83";"10.10";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3928540";"";"0";"470.88";"0";"4.63";"BDBM158493";"CNC(=O)c1cc(OC2CCC(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"301050";"UO_0000065";"19.75";"0.40";"4.67";"10.07";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL444191";"";"0";"600.49";"3";"0.74";"11";"O=C(O[C@H]1[C@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)O[C@H](CO)[C@@H](O)[C@@H]1O)c1cc(O)c(O)c(O)c1";"IC50";"'='";"27430.0";"nM";"4.56";"";"";"UO_0000065";"7.60";"0.14";"3.82";"1.77";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL250450";"ISOQUERCETIN";"2";"464.38";"2";"-0.54";"17";"O=c1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12";"IC50";"'='";"28430.0";"nM";"4.55";"";"";"UO_0000065";"9.79";"0.19";"5.09";"2.16";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL222160";"";"0";"372.40";"0";"4.04";"91";"O=C(Nc1ccc(C(=O)O)cc1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"142.0";"nM";"6.85";"";"";"UO_0000065";"18.39";"0.35";"2.81";"7.81";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2392703";"";"0";"406.45";"0";"3.98";"15";"CNc1cc(C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392700";"";"0";"407.44";"0";"3.38";"12";"CNc1cc(C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392713";"";"0";"494.57";"0";"2.46";"8b";"CNc1nc(N(C)CCN(C)C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3809434";"";"0";"296.41";"0";"4.07";"8e(S)";"CC[C@H](NC(=O)NCCCc1ccccc1)c1ccccc1";"IC50";"'='";"36.0";"nM";"7.44";"";"";"UO_0000065";"25.11";"0.46";"3.37";"18.10";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3764546";"";"0";"423.43";"0";"4.65";"9b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccc(OC(F)(F)F)cc2)cc1";"IC50";"'='";"900.0";"nM";"6.05";"";"";"UO_0000065";"14.28";"0.28";"1.40";"9.35";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764076";"";"0";"403.48";"1";"5.06";"12c";"CCC(Cc1ccc(C(=O)NCc2ccc(Oc3ccccc3)cc2)cc1)C(=O)O";"IC50";"'='";"12000.0";"nM";"4.92";"";"";"UO_0000065";"12.20";"0.22";"-0.14";"6.51";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3236511";"";"0";"600.49";"3";"1.47";"13";"C[C@@H]1O[C@@H](Oc2c(-c3ccc(O)c(O)c3)oc3cc(O)cc(O)c3c2=O)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](O)[C@H]1O";"IC50";"'='";"18640.0";"nM";"4.73";"";"";"UO_0000065";"7.88";"0.15";"3.26";"1.84";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3222125";"";"0";"263.38";"0";"1.57";"7a";"O=C(NC12CC3CC(CC(C3)C1)C2)N1CCNCC1";"IC50";"'='";"100000.0";"nM";"4.00";"";"";"UO_0000065";"15.19";"0.29";"2.43";"9.02";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3818976";"";"0";"547.04";"2";"6.17";"8d";"CCCCCCC(Sc1nc(Cl)cc(NCCCC(=O)NCc2ccccc2C(F)(F)F)n1)C(=O)O";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"10.82";"0.22";"-0.25";"5.68";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL2070332";"";"0";"390.57";"0";"4.55";"11";"CCCCCOC(=O)C1CCCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)C1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"22.27";"0.42";"4.15";"12.90";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1668936";"";"0";"365.38";"0";"2.25";"25";"CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"T1/2";"'='";"0.08367";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3629064";"";"0";"498.56";"1";"6.53";"32";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)c2ccc3cc(O)ccc3c2)cc1)C(C)(C)C";"IC50";"'='";"17.0";"nM";"7.77";"";"";"UO_0000065";"15.58";"0.30";"1.24";"8.02";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628774";"";"0";"546.73";"2";"7.84";"21";"CC(C)COP(=O)(OCC(C)C)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"14.26";"0.28";"-0.04";"10.17";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628772";"";"0";"518.68";"2";"7.35";"19";"CC(C)OP(=O)(OC(C)C)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"6.7";"nM";"8.17";"";"";"UO_0000065";"15.76";"0.31";"0.82";"10.66";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628768";"";"0";"476.60";"1";"6.32";"15";"CCCC(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)P(=O)(OCC)OCC";"IC50";"'='";"58.0";"nM";"7.24";"";"";"UO_0000065";"15.18";"0.30";"0.92";"9.44";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628764";"";"0";"538.63";"2";"6.41";"11";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(=O)c1ccccc1";"IC50";"'='";"69.0";"nM";"7.16";"";"";"UO_0000065";"13.30";"0.26";"0.75";"7.64";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL2313175";"";"0";"414.57";"0";"4.47";"7-37";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(C(C)C)cc3)CC2)c(C)c1";"IC50";"'='";"6.7";"nM";"8.17";"";"";"UO_0000065";"19.72";"0.38";"3.70";"12.30";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313183";"";"0";"466.56";"0";"4.19";"7-45";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc4cc(C(=O)O)ccc4c3)CC2)c(C)c1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"19.77";"0.38";"5.03";"8.89";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313170";"";"0";"402.52";"0";"3.35";"7-32";"COc1ccc(NC(=O)C2CCN(S(=O)(=O)c3ccc(C)cc3C)CC2)cc1";"IC50";"'='";"25.0";"nM";"7.60";"";"";"UO_0000065";"18.89";"0.37";"4.25";"10.04";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313163";"";"0";"350.48";"0";"2.37";"7-25";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCC3)CC2)c(C)c1";"IC50";"'='";"29.0";"nM";"7.54";"";"";"UO_0000065";"21.51";"0.43";"5.17";"11.34";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313201";"";"0";"441.38";"0";"4.65";"7-18";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3cc(Cl)cc(Cl)c3)CC2)c(C)c1";"IC50";"'='";"25.0";"nM";"7.60";"";"";"UO_0000065";"17.22";"0.37";"2.95";"11.44";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313192";"";"0";"388.49";"0";"3.05";"7-9";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3O)CC2)c(C)c1";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"22.96";"0.45";"5.87";"10.29";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1672129";"";"0";"279.30";"0";"2.51";"7";"O=C(N[C@H]1C[C@@H]1c1ccccc1)c1ccc2nonc2c1";"IC50";"'='";"61.66";"nM";"7.21";"";"";"UO_0000065";"25.81";"0.47";"4.70";"10.60";"False";"CHEMBL1680920";"Inhibition of human soluble epoxide hydrolase in cell free system";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1672128";"";"0";"321.42";"0";"3.47";"6, diastereomeric mixture";"COc1cccc2c1CC(C(=O)N[C@H]1C[C@@H]1c1ccccc1)CC2";"IC50";"'='";"4.677";"nM";"8.33";"";"";"UO_0000065";"25.92";"0.47";"4.86";"21.73";"False";"CHEMBL1680922";"Inhibition of soluble epoxide hydrolase in human HepG2 cells after 30 mins";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1671815";"1";"Scientific Literature";"J. Med. Chem.";"2011";"CHEMBL3307718"
"CHEMBL1258221";"";"0";"293.34";"0";"2.35";"BDBM50327832";"CCC(=O)N1CCC(NC(=O)Nc2ccc(F)cc2)CC1";"IC50";"'='";"79.0";"nM";"7.10";"";"377027";"UO_0000065";"24.21";"0.46";"4.75";"11.56";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257990";"";"0";"365.43";"0";"2.23";"BDBM50327840";"CCC(=O)N1CCC(NC(=O)Nc2cc(OC)c(OC)c(OC)c2)CC1";"IC50";"'>'";"5000.0";"nM";"";"";"377021";"UO_0000065";"";"";"";"";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1258219";"";"0";"319.36";"0";"1.91";"BDBM50327834";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"330.0";"nM";"6.48";"";"377025";"UO_0000065";"20.30";"0.38";"4.57";"6.56";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1258448";"";"0";"293.34";"0";"2.35";"BDBM50327833";"CCC(=O)N1CCC(NC(=O)Nc2ccccc2F)CC1";"IC50";"'='";"300.0";"nM";"6.52";"";"377032";"UO_0000065";"22.24";"0.42";"4.17";"10.62";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL2180625";"";"0";"461.44";"0";"4.93";"5g";"CCOC(=O)c1cccn1Cc1ccccc1CNC(=O)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"2009.0";"nM";"5.70";"";"";"UO_0000065";"12.35";"0.24";"0.77";"6.98";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL2180620";"";"0";"383.49";"0";"3.85";"5b";"CCOC(=O)c1cccn1Cc1cccc(CNC(=O)NC2CCCCC2)c1";"IC50";"'='";"27.0";"nM";"7.57";"";"";"UO_0000065";"19.74";"0.37";"3.72";"10.46";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL478322";"";"0";"466.63";"0";"3.71";"138";"O=C(Nc1cccc(C(=O)N2CCC(N3CCOCC3)CC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"28.7";"nM";"7.54";"";"";"UO_0000065";"16.16";"0.30";"3.83";"10.20";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1535088";"";"0";"321.47";"0";"1.98";"144";"O=C(NCCCN1CCOCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"610.4";"nM";"6.21";"";"";"UO_0000065";"19.33";"0.37";"4.23";"11.59";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1818405";"";"0";"292.74";"0";"4.11";"25";"Cc1ccc(NC(=O)NCc2cccc(F)c2)cc1Cl";"IC50";"'='";"16.6";"nM";"7.78";"";"";"UO_0000065";"26.58";"0.53";"3.67";"18.92";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL2436560";"";"0";"429.47";"0";"4.13";"8";"COc1ccc(NC(=O)N2CCC3(CCN(C(=O)c4c(F)cccc4F)CC3)C2)cc1";"IC50";"'='";"151.6";"nM";"6.82";"";"";"UO_0000065";"15.88";"0.30";"2.69";"11.02";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436569";"";"0";"468.33";"1";"5.43";"17";"O=C(Nc1ccc(Cl)c(Cl)c1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"3.5";"nM";"8.46";"";"";"UO_0000065";"18.06";"0.37";"3.03";"16.06";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348403";"";"0";"350.37";"0";"2.58";"3c";"CC(C)C(NC(=O)OC(C)(C)C)C(=O)Oc1cccc2oc(=O)[nH]c12";"Inhibition";"'='";"48.02";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348393";"";"0";"325.73";"0";"2.54";"5d";"O=c1[nH]c2c(OS(=O)(=O)c3ccc(Cl)cc3)cccc2o1";"Inhibition";"'='";"13.62";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348396";"";"0";"336.28";"0";"1.80";"5g";"O=c1[nH]c2c(OS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cccc2o1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1818416";"";"0";"266.38";"0";"2.29";"37";"CCOCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"524.8";"nM";"6.28";"";"";"UO_0000065";"23.58";"0.45";"3.99";"12.47";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818391";"";"0";"272.27";"0";"3.56";"8";"O=C(Nc1ccc(F)c(F)c1F)NC1CCCCC1";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"32.76";"0.64";"5.36";"21.69";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL4078726";"";"0";"262.31";"0";"1.00";"4b";"O=C(O)c1ccc(CNC(=O)C2CCNCC2)cc1";"Inhibition";"'<'";"3.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL3764672";"";"0";"390.28";"0";"4.03";"5c";"CCC(Cc1ccc(C(=O)NCc2ccccc2Br)cc1)C(=O)O";"Inhibition";"'='";"34.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3767858";"Inhibition of human recombinant sEH using PHOME as substrate at 10 uM preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3765080";"";"0";"405.42";"0";"4.99";"15a";"CCOC(=O)/C(=C/c1cccc(C(=O)NCc2ccccc2C(F)(F)F)c1)CC";"IC50";"'='";"40.0";"nM";"7.40";"";"";"UO_0000065";"18.25";"0.35";"2.41";"13.35";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3763432";"";"0";"407.43";"0";"4.77";"8b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccc(C(F)(F)F)cc2)cc1";"IC50";"'='";"570.0";"nM";"6.24";"";"";"UO_0000065";"15.33";"0.29";"1.47";"11.27";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764102";"";"0";"379.38";"0";"4.29";"8c";"CCC(Cc1ccc(C(=O)NCc2ccc(C(F)(F)F)cc2)cc1)C(=O)O";"IC50";"'='";"7200.0";"nM";"5.14";"";"";"UO_0000065";"13.56";"0.26";"0.85";"7.74";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL2436574";"";"0";"481.90";"1";"5.40";"22";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3ccccc3Cl)CC2)C1";"IC50";"'='";"0.3";"nM";"9.52";"";"";"UO_0000065";"19.76";"0.39";"4.12";"15.39";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436593";"";"0";"491.51";"0";"4.77";"41";"O=C(CCc1cccc(O)c1)N1CCC2(CC1)CCN(C(=O)Nc1ccc(OC(F)(F)F)cc1)C2";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"19.12";"0.37";"4.63";"11.45";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313166";"";"0";"406.59";"0";"3.93";"7-28";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC3CCCCCCC3)CC2)c(C)c1";"IC50";"'='";"2.8";"nM";"8.55";"";"";"UO_0000065";"21.04";"0.42";"4.62";"12.87";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1271550";"";"0";"408.38";"1";"5.21";"4";"O=C(Nc1ccc(-n2nc(-c3cccnc3)cc2C(F)(F)F)cc1)c1ccccc1";"IC50";"'='";"6.2";"nM";"8.21";"";"";"UO_0000065";"20.10";"0.37";"3.00";"13.72";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL3808397";"";"0";"234.34";"0";"2.72";"8j(RS)";"CCC(C)NC(=O)NCCCc1ccccc1";"IC50";"'='";"650.0";"nM";"6.19";"";"";"UO_0000065";"26.40";"0.50";"3.47";"15.04";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"59.0";"nM";"7.23";"";"";"UO_0000065";"18.41";"0.35";"1.99";"9.22";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3808618";"";"0";"361.47";"0";"2.33";"8k(R)";"C[C@@H](NC(=O)NCCCc1ccc(S(N)(=O)=O)cc1)c1ccccc1";"IC50";"'='";"2030.0";"nM";"5.69";"";"";"UO_0000065";"15.75";"0.31";"3.36";"5.62";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL1818398";"";"0";"250.39";"0";"2.91";"16";"CC(C)(C)NC(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"24.2";"nM";"7.62";"";"";"UO_0000065";"30.42";"0.58";"4.71";"18.52";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL2037375";"";"0";"268.32";"0";"3.56";"6";"COc1ccc(-c2nc3cc(C)ccc3[nH]2)cc1OC";"IC50";"'='";"3500.0";"nM";"5.46";"";"";"UO_0000065";"20.33";"0.37";"1.90";"11.57";"False";"CHEMBL2039369";"Inhibition of soluble epoxide hydrolase using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to substrate addition measured every min for 15 mins by fluorometry";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2034900";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None"
"CHEMBL2031942";"";"0";"578.75";"2";"5.80";"100";"CCOCCOCCOc1ccc(C(OC(=O)CCCNC(=O)NC23CC4CC(CC(C4)C2)C3)c2ccccc2)cc1";"IC50";"'='";"5.1";"nM";"8.29";"";"";"UO_0000065";"14.33";"0.27";"2.49";"8.72";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL436774";"AR9281";"2";"319.45";"0";"2.27";"5a";"CC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"25.53";"0.48";"5.88";"13.27";"True";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL214675";"";"0";"361.53";"0";"3.29";"6c";"CCCC(=O)N1CCC(CNC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"6.7";"nM";"8.17";"";"";"UO_0000065";"22.61";"0.43";"4.88";"13.30";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL426340";"";"0";"391.51";"0";"2.50";"7g";"O=C(O)CCCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"72.0";"nM";"7.14";"";"";"UO_0000065";"18.24";"0.35";"4.64";"7.23";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL215827";"";"0";"391.51";"0";"2.20";"7a";"COC(=O)CCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"9.0";"nM";"8.05";"";"";"UO_0000065";"20.55";"0.39";"5.85";"9.17";"False";"CHEMBL912696";"Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1146911";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL2032042";"";"0";"472.67";"0";"3.14";"136";"O=C(NC1CCCC(C(=O)N2CCC(N3CCOCC3)CC2)C1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"6.1";"nM";"8.21";"";"";"UO_0000065";"17.38";"0.33";"5.07";"11.11";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031788";"";"0";"502.66";"1";"4.41";"143";"O=C(Nc1cccc(C(=O)NCC2CN(Cc3ccccc3)CCO2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"13.6";"nM";"7.87";"";"";"UO_0000065";"15.65";"0.29";"3.46";"9.51";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031948";"";"0";"394.56";"0";"3.62";"109";"C=C(CCCNC(=O)NC12CC3CC(CC(C3)C1)C2)OCCOCCOCC";"IC50";"'='";"67.0";"nM";"7.17";"";"";"UO_0000065";"18.18";"0.35";"3.55";"10.42";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031937";"";"0";"380.24";"1";"5.13";"94";"O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"9.6";"nM";"8.02";"";"";"UO_0000065";"21.09";"0.42";"2.89";"13.45";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL242470";"";"0";"306.45";"0";"3.21";"118";"CO[C@H]1CC[C@@H](NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"5.1";"nM";"8.29";"";"";"UO_0000065";"27.06";"0.51";"5.08";"16.47";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL244192";"";"0";"398.55";"0";"4.65";"121";"COc1ccc(O[C@H]2CC[C@@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"23.34";"0.44";"4.65";"15.61";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2392708";"";"0";"370.46";"0";"1.76";"20";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3OC)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392701";"";"0";"407.44";"0";"3.38";"13";"CNc1cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)nc(C)n1";"IC50";"'='";"80.0";"nM";"7.10";"";"";"UO_0000065";"17.42";"0.33";"3.72";"10.12";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3818875";"";"0";"447.47";"0";"3.40";"GSK2256294A";"CNc1nc(C)nc(N[C@H]2CCC[C@@H](C(=O)NCc3ccc(C#N)cc3C(F)(F)F)C2)n1";"IC50";"'='";"110.0";"nM";"6.96";"";"";"UO_0000065";"15.55";"0.30";"3.56";"6.02";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL264374";"BEZAFIBRATE";"4";"361.83";"0";"3.55";"Bezafibrate";"CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(=O)O";"IC50";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL2031799";"";"0";"338.37";"0";"4.80";"4";"O=C(Nc1cccc(C(F)(F)F)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.4";"nM";"8.62";"";"";"UO_0000065";"25.47";"0.49";"3.82";"20.96";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031801";"";"0";"284.40";"0";"4.09";"9";"Cc1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"6.1";"nM";"8.21";"";"";"UO_0000065";"28.88";"0.53";"4.12";"19.97";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL3628778";"";"0";"533.69";"2";"7.28";"25";"CC(C)OP(=O)(OC(C)C)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"16.43";"0.32";"1.49";"9.89";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3809679";"";"0";"308.43";"0";"4.17";"8i(R)";"O=C(NCCCc1ccccc1)N1CCC[C@@H]1c1ccccc1";"IC50";"'='";"1510.0";"nM";"5.82";"";"";"UO_0000065";"18.87";"0.35";"1.65";"18.00";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3810131";"";"0";"308.43";"0";"4.17";"8i(S)";"O=C(NCCCc1ccccc1)N1CCC[C@H]1c1ccccc1";"IC50";"'='";"332.0";"nM";"6.48";"";"";"UO_0000065";"21.01";"0.38";"2.31";"20.03";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL1077963";"";"0";"387.87";"0";"4.17";"3f";"O=C(O)CCC1(c2ccccn2)CCCN(C(=O)Nc2ccc(Cl)cc2)C1";"IC50";"'='";"19.0";"nM";"7.72";"";"";"UO_0000065";"19.91";"0.39";"3.55";"9.36";"False";"CHEMBL1100033";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1154229";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2392737";"";"0";"304.39";"0";"3.14";"49";"CC(C)c1nnc(NC(=O)NC2C3CC4CC(C3)CC2C4)o1";"IC50";"'='";"843.0";"nM";"6.07";"";"";"UO_0000065";"19.96";"0.38";"2.93";"7.59";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392751";"";"0";"272.35";"0";"2.57";"18";"O=C(Nc1ccncn1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"775.0";"nM";"6.11";"";"";"UO_0000065";"22.44";"0.42";"3.54";"9.13";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392749";"";"0";"271.36";"0";"3.17";"15";"O=C(Nc1cccnc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"113.0";"nM";"6.95";"";"";"UO_0000065";"25.60";"0.47";"3.78";"12.86";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL3818059";"";"0";"348.79";"0";"3.51";"3c";"CC(Oc1ccc(CNC(=O)Nc2ccc(Cl)cc2)cc1)C(=O)O";"IC50";"'='";"850.0";"nM";"6.07";"";"";"UO_0000065";"17.40";"0.35";"2.56";"6.93";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL1231797";"";"0";"344.20";"0";"3.75";"CIU";"O=C(Nc1ccc(I)cc1)NC1CCCCC1";"IC50";"'='";"140.0";"nM";"6.85";"";"";"UO_0000065";"19.91";"0.55";"3.10";"16.66";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL4127878";"";"0";"342.55";"0";"4.30";"1i";"S=C(NCCc1ccccc1)NCCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"52.0";"nM";"7.28";"";"";"UO_0000065";"21.26";"0.41";"2.98";"30.27";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL2398216";"DIOCTYLSULFANE";"0";"258.51";"1";"6.44";"7";"CCCCCCCCSCCCCCCCC";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL2400592";"Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonate) as substrate preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1632460";"";"0";"454.62";"0";"3.71";"28c";"CC(=O)N1CCN(CCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1";"IC50";"'='";"3.3";"nM";"8.48";"";"";"UO_0000065";"18.66";"0.35";"4.77";"11.48";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632442";"";"0";"426.61";"0";"3.79";"16b";"CN1CCN(CCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"23.1";"nM";"7.64";"";"";"UO_0000065";"17.90";"0.34";"3.85";"13.43";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632483";"";"0";"503.09";"1";"4.32";"39";"O=C(Nc1cccc(OCCCCN2CCN(C(=O)CCl)CC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.4";"nM";"8.85";"";"";"UO_0000065";"17.60";"0.35";"4.53";"11.98";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL2336311";"";"0";"581.64";"2";"7.28";"8i";"COc1cc(-c2nc3ccc(C)cn3c2NC2CCCC2)ccc1OCCCNC(=O)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"70.0";"nM";"7.16";"";"";"UO_0000065";"12.30";"0.23";"-0.13";"8.05";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2348192";"";"0";"300.23";"0";"2.25";"4f";"O=C(Oc1cccc2oc(=O)[nH]c12)c1cccc([N+](=O)[O-])c1";"Inhibition";"'='";"92.86";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348397";"";"0";"305.31";"0";"2.20";"5h";"Cc1ccccc1S(=O)(=O)Oc1cccc2oc(=O)[nH]c12";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL4068980";"";"0";"213.28";"0";"3.01";"6";"CC(C)=C/C=C1\C(=O)N(C)c2ccccc21";"IC50";"'='";"1300.0";"nM";"5.89";"";"";"UO_0000065";"27.60";"0.50";"2.88";"28.98";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4090057";"";"0";"213.28";"0";"3.01";"5";"CC(C)=C/C=C1/C(=O)N(C)c2ccccc21";"IC50";"'='";"800.0";"nM";"6.10";"";"";"UO_0000065";"28.59";"0.52";"3.09";"30.02";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL1234565";"";"0";"369.43";"0";"4.14";"1";"CCc1cc(-c2cccnc2)nn1-c1ccc(NC(=O)c2cccnc2)cc1";"IC50";"'='";"41.0";"nM";"7.39";"";"";"UO_0000065";"20.00";"0.36";"3.25";"10.16";"False";"CHEMBL1273199";"Inhibition of human Ephx2 after 30 mins by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1268990";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL470389";"";"0";"447.62";"1";"5.28";"19d";"O=C(NCCc1ccc(OCc2ccccc2)cc1)C(O)CCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"17.78";"0.33";"2.68";"13.59";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL460837";"";"0";"428.57";"0";"3.30";"16a";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)C(O)C12CC3CC(CC(C3)C1)C2";"IC50";"'>'";"2000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL460428";"";"0";"426.56";"0";"3.51";"17a";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)C(=O)C12CC3CC(CC(C3)C1)C2";"IC50";"'>'";"2000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2070328";"";"0";"378.56";"0";"4.55";"6";"CCCCC(CC)OC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"22.18";"0.42";"3.85";"12.45";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL2070334";"";"0";"512.69";"2";"5.15";"13";"CCOCCOCC(OC(=O)C1CCCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)C1)c1ccccc1";"IC50";"'='";"9.0";"nM";"8.05";"";"";"UO_0000065";"15.69";"0.30";"2.90";"9.37";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL1358";"FULVESTRANT";"4";"606.78";"2";"8.68";"15G10";"C[C@]12CC[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCCCC[S+]([O-])CCCC(F)(F)C(F)(F)F)[C@H]3[C@@H]1CC[C@@H]2O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL2400591";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL242459";"";"0";"412.53";"0";"4.34";"11, t-AUCB";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"Inhibition";"'='";"69.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2400594";"Inhibition of human recombinant soluble epoxide hydrolase using ((3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate at 10 nM preincubated for 5 mins prior to substrate addition measured after 60 mins by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL590600";"";"0";"353.34";"0";"4.26";"1, Figure1";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC(n2cccc2)CC1";"IC50";"'='";"126.0";"nM";"6.90";"";"";"UO_0000065";"19.53";"0.38";"2.64";"14.84";"False";"CHEMBL1118602";"Inhibition of human soluble epoxide hydrolase assessed as [2-3H]trans-1,3-diphenyl propylene oxide hydrolysis by cellular assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1155546";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL471450";"";"0";"450.60";"0";"4.48";"8-2";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3cccc4ccccc34)CC2)c(C)c1";"IC50";"'='";"39.4";"nM";"7.41";"";"";"UO_0000065";"16.43";"0.32";"2.92";"11.14";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL477671";"";"0";"286.38";"0";"3.48";"3";"O=C(Nc1cccc(O)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"28.0";"nM";"7.55";"";"";"UO_0000065";"26.37";"0.49";"4.07";"12.31";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL476056";"";"0";"328.41";"0";"3.70";"8";"CC(=O)Oc1cccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"5.8";"nM";"8.24";"";"";"UO_0000065";"25.08";"0.47";"4.54";"12.21";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL476058";"";"0";"328.41";"0";"3.70";"10";"CC(=O)Oc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"3.9";"nM";"8.41";"";"";"UO_0000065";"25.60";"0.48";"4.71";"12.47";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL478147";"";"0";"328.41";"0";"3.40";"19";"O=C(O)Cc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"392.0";"nM";"6.41";"";"";"UO_0000065";"19.51";"0.36";"3.01";"8.17";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL476614";"";"0";"344.41";"0";"3.27";"28";"COC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1O";"IC50";"'='";"2.8";"nM";"8.55";"";"";"UO_0000065";"24.83";"0.47";"5.28";"9.76";"True";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL568745";"";"0";"251.29";"0";"3.35";"6g";"c1ccc(CNc2nnc(-c3ccccc3)o2)cc1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL579018";"";"0";"229.16";"0";"2.83";"6j";"FC(F)(F)c1nnc(Nc2ccccc2)o1";"IC50";"'='";"2000.0";"nM";"5.70";"";"";"UO_0000065";"24.87";"0.49";"2.87";"11.19";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL578566";"";"0";"279.22";"0";"3.99";"7h";"FC(F)(F)c1ccc(Nc2noc3ncccc23)cc1";"IC50";"'='";"27.0";"nM";"7.57";"";"";"UO_0000065";"27.11";"0.52";"3.58";"14.86";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL578782";"";"0";"286.33";"1";"5.24";"7p";"c1ccc(-c2ccc(Nc3noc4ccccc34)cc2)cc1";"IC50";"'='";"170.0";"nM";"6.77";"";"";"UO_0000065";"23.64";"0.42";"1.53";"17.79";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL577471";"";"0";"260.30";"0";"4.72";"7r";"c1ccc2cc(Nc3noc4ccccc34)ccc2c1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"22.75";"0.40";"1.20";"15.56";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL568696";"";"0";"346.23";"1";"5.61";"7v";"FC(F)(F)c1ccc(Nc2noc3ccc(C(F)(F)F)cc23)cc1";"IC50";"'='";"40.0";"nM";"7.40";"";"";"UO_0000065";"21.37";"0.42";"1.79";"19.44";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL216164";"";"0";"500.64";"1";"2.98";"Table 3, r12c1";"O=C(CCCCCNC(=O)NC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"13.98";"0.27";"4.02";"5.48";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL374888";"";"0";"494.64";"0";"4.11";"Table 2, r16c3";"O=C(CCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O";"IC50";"'='";"41000.0";"nM";"4.39";"";"";"UO_0000065";"8.87";"0.17";"0.28";"3.56";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL218061";"";"0";"355.48";"0";"2.40";"Table 1, r21c1";"CC(C)[C@H](NC(=O)CCCCCNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'='";"41000.0";"nM";"4.39";"";"";"UO_0000065";"12.34";"0.24";"1.99";"4.08";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219596";"";"0";"393.49";"0";"1.71";"Table 1, r19c1";"O=C(CCCCCNC(=O)NC1CCCCC1)N[C@@H](Cc1cnc[nH]1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219694";"";"0";"299.37";"0";"0.84";"Table 1, r7c1";"CC(C)[C@H](NC(=O)CNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219693";"";"0";"347.42";"0";"1.43";"Table 1, r6c1";"O=C(CNC(=O)NC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219024";"";"0";"329.35";"0";"0.05";"Table 1, r4c1";"O=C(O)CC[C@H](NC(=O)CNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL219023";"";"0";"356.43";"1";"-0.55";"Table 1, r3c1";"N=C(N)NCCC[C@H](NC(=O)CNC(=O)NC1CCCCC1)C(=O)O";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL907007";"Inhibition of human recombinant soluble Epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137287";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL374322";"";"0";"386.51";"0";"4.78";"1{1}";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"24.06";"0.45";"4.52";"18.47";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL221793";"";"0";"348.46";"0";"4.54";"1{4}";"O=C(NC1CCCCCC1)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"26.69";"0.51";"4.76";"18.47";"False";"CHEMBL910697";"Inhibition of human recombinant soluble epoxide hydrolase by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL221446";"";"0";"356.44";"0";"4.95";"1{38}";"Cc1cccc(C)c1NC(=O)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"Inhibition";"'='";"4.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL910698";"Inhibition of human recombinant soluble epoxide hydrolase at 100 nM by end-point fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1139717";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2006";"None"
"CHEMBL1258670";"";"0";"343.35";"0";"3.23";"2";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"2.96";"nM";"8.53";"";"";"UO_0000065";"24.84";"0.49";"5.30";"13.88";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL497829";"";"0";"468.40";"0";"4.33";"2c";"CS(=O)(=O)c1ccc2c(c1)CCC1(CCN(C(=O)Cc3ccc(Cl)cc3Cl)CC1)O2";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.21";"0.41";"4.67";"14.13";"False";"CHEMBL1001508";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL495792";"";"0";"456.55";"0";"4.15";"rac-1c";"Cn1nccc1-c1ccc2c(c1)C(=O)CC1(CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC1)O2";"IC50";"'<'";"1.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1001510";"Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1137005";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307715"
"CHEMBL458166";"";"0";"361.49";"0";"3.24";"12b";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)NC1CCCCC1";"IC50";"'='";"3.9";"nM";"8.41";"";"";"UO_0000065";"23.26";"0.44";"5.17";"13.38";"True";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL551126";"";"0";"373.43";"0";"3.57";"12e";"O=C(Nc1ccc(F)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"21.03";"0.40";"4.28";"12.50";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL565016";"";"0";"391.42";"0";"3.71";"12g";"O=C(Nc1cccc(OCCCN2CCOCC2)c1)Nc1ccc(F)cc1F";"IC50";"'='";"121.0";"nM";"6.92";"";"";"UO_0000065";"17.67";"0.34";"3.21";"11.01";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL456632";"";"0";"412.57";"0";"4.33";"14c";"O=C(CC12CC3CC(CC(C3)C1)C2)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"2.5";"nM";"8.60";"";"";"UO_0000065";"20.85";"0.39";"4.27";"16.93";"True";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL32969";"";"0";"208.21";"0";"1.59";"7";"COC(=O)/C=C/c1ccc(O)c(OC)c1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4010817";"Mixed type inhibition of sEH (unknown origin) at 0.78 to 6.25 uM using PHOME as substrate measured for 30 mins by Lineweaver-burk plot method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL3327069";"";"0";"397.32";"0";"3.77";"9";"O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)CC(F)(F)F)CC1";"Ki";"'='";"0.43";"nM";"9.37";"";"";"UO_0000065";"23.57";"0.47";"5.60";"15.25";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL566648";"";"0";"487.19";"1";"5.00";"41";"O=C(NCc1ccc(Br)cc1OC(F)(F)F)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"0.1";"nM";"10.00";"";"";"UO_0000065";"20.53";"0.47";"5.00";"16.54";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL567294";"";"0";"426.79";"0";"2.97";"43";"O=C(NCc1ccc(-n2cnnn2)cc1Cl)c1ccc(OCCC(F)(F)F)nc1";"IC50";"'='";"38.0";"nM";"7.42";"";"";"UO_0000065";"17.39";"0.35";"4.45";"7.83";"False";"CHEMBL1039071";"Inhibition of soluble EH in human HepG2 cells by cellular assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"CHEMBL3307718"
"CHEMBL381544";"";"0";"346.45";"0";"2.56";"44";"CC(C)(C)c1ccc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)cc1";"IC50";"'='";"280.0";"nM";"6.55";"";"";"UO_0000065";"18.91";"0.37";"3.99";"7.34";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL1098469";"";"0";"368.44";"0";"2.39";"5o, meta isomer";"O=C(Nc1ccccc1)Nc1cccc(C(=O)NCCN2CCOCC2)c1";"IC50";"'='";"2800.0";"nM";"5.55";"";"";"UO_0000065";"15.07";"0.28";"3.16";"6.71";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1096452";"";"0";"442.95";"0";"3.92";"5u, meta isomer";"O=C(Nc1ccc(Cl)cc1)Nc1cccc(C(=O)N2CCC(N3CCOCC3)CC2)c1";"IC50";"'='";"47.0";"nM";"7.33";"";"";"UO_0000065";"16.54";"0.32";"3.41";"9.91";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1087345";"";"0";"420.87";"0";"3.19";"6d, meta isomer";"O=C(Nc1ccc(Cl)cc1)Nc1ccc(F)c(C(=O)NCCN2CCOCC2)c1";"IC50";"'='";"38.0";"nM";"7.42";"";"";"UO_0000065";"17.63";"0.35";"4.23";"8.97";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088373";"";"0";"385.46";"0";"2.93";"5b,para isomer";"CN(CC(=O)O)C(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"200.0";"nM";"6.70";"";"";"UO_0000065";"17.38";"0.33";"3.77";"6.78";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1097684";"";"0";"356.40";"0";"2.86";"5g,para isomer";"CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(F)cc3)cc2)CC1";"IC50";"'='";"160.0";"nM";"6.80";"";"";"UO_0000065";"19.07";"0.36";"3.94";"10.51";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1086821";"";"0";"452.43";"0";"3.29";"5s,para isomer";"O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccc(C(=O)NCCN2CCOCC2)cc1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"19.23";"0.37";"5.41";"9.46";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL1088351";"";"0";"472.49";"0";"2.96";"9b, para isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(S(=O)(=O)NCCN2CCOCC2)cc1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"18.04";"0.36";"5.56";"8.54";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL589133";"";"0";"378.30";"0";"4.55";"29";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Cc2ccccn2)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"20.94";"0.43";"3.37";"17.51";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL589375";"";"0";"463.28";"1";"5.65";"38";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"17.10";"0.36";"2.27";"15.59";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL589859";"";"0";"404.30";"0";"4.62";"41";"N#Cc1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"IC50";"'='";"4.2";"nM";"8.38";"";"";"UO_0000065";"20.72";"0.42";"3.76";"12.82";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2348394";"";"0";"336.28";"0";"1.80";"5e";"O=c1[nH]c2c(OS(=O)(=O)c3ccccc3[N+](=O)[O-])cccc2o1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3114617";"";"0";"426.56";"1";"5.52";"10";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(OC(c2ccccc2)c2ccccc2)CC1";"IC50";"'='";"27.1";"nM";"7.57";"";"";"UO_0000065";"17.74";"0.32";"2.05";"18.20";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114611";"";"0";"336.44";"0";"3.80";"3";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccccc2)CC1";"IC50";"'='";"18.0";"nM";"7.75";"";"";"UO_0000065";"23.02";"0.42";"3.94";"18.63";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3104443";"";"0";"478.47";"0";"3.45";"40";"O=C(Cc1ccccn1)N1CCC2(CC1)CN(C(=O)Nc1ccc(OC(F)(F)F)cc1)CCO2";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"19.13";"0.37";"5.70";"10.90";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104442";"";"0";"507.51";"1";"4.06";"39";"COc1ccccc1CC(=O)N1CCC2(CC1)CN(C(=O)Nc1ccc(OC(F)(F)F)cc1)CCO2";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"18.33";"0.35";"5.24";"11.58";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104436";"";"0";"479.46";"0";"3.22";"33";"Cc1cnc(C(=O)N2CCC3(CC2)CN(C(=O)Nc2ccc(OC(F)(F)F)cc2)CCO3)cn1";"IC50";"'='";"0.9";"nM";"9.05";"";"";"UO_0000065";"18.87";"0.36";"5.83";"9.34";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104433";"";"0";"493.49";"0";"3.72";"30";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3c[nH]nc3C3CC3)CC2)C1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"18.15";"0.35";"5.24";"8.98";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104615";"";"0";"497.46";"1";"5.41";"15";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"0.125";"nM";"9.90";"";"";"UO_0000065";"19.91";"0.39";"4.49";"16.00";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104444";"";"0";"499.44";"0";"4.40";"2";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"18.33";"0.36";"4.75";"12.87";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3322812";"";"0";"413.59";"0";"3.35";"17";"CCCCCNC(=O)NCCCC/C=C\CCCCCS(=O)(=O)c1ncn[nH]1";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"18.47";"0.37";"4.29";"6.54";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3104434";"";"0";"448.45";"0";"3.64";"31";"O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccccn3)CC2)C1";"IC50";"'='";"4.2";"nM";"8.38";"";"";"UO_0000065";"18.68";"0.36";"4.74";"11.20";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104623";"";"0";"472.47";"0";"4.12";"26";"N#Cc1ccc(C(=O)N2CCC3(CC2)CN(C(=O)Nc2ccc(C(F)(F)F)cc2)CCO3)cc1";"IC50";"'='";"1.9";"nM";"8.72";"";"";"UO_0000065";"18.46";"0.35";"4.60";"10.18";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3103802";"";"0";"386.45";"0";"1.96";"8";"COC(=O)c1ccc(CONC(=O)C(=O)NC2C3CC4CC(C3)CC2C4)cc1";"IC50";"'='";"1500.0";"nM";"5.82";"";"";"UO_0000065";"15.07";"0.28";"3.86";"6.21";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3763179";"";"0";"392.38";"0";"3.67";"20";"CON(C)C(=O)/C=C/c1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1";"IC50";"'='";"70.0";"nM";"7.16";"";"";"UO_0000065";"18.23";"0.35";"3.48";"12.20";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764773";"";"0";"407.43";"0";"4.77";"1b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1";"IC50";"'='";"44.0";"nM";"7.36";"";"";"UO_0000065";"18.06";"0.35";"2.59";"13.28";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL461085";"CHRYSOOBTUSIN";"0";"358.35";"0";"2.51";"3";"COc1cc2c(c(OC)c1OC)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"IC50";"'='";"26300.0";"nM";"4.58";"";"";"UO_0000065";"12.78";"0.24";"2.07";"5.02";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"Inhibition";"'='";"64.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3634702";"";"0";"608.55";"3";"-2.51";"15";"COc1cc(O[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)c2c(c1)C(=O)c1cc(C)cc(O)c1C2=O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3104438";"";"0";"427.47";"0";"3.98";"35";"CC(C)(C)C(=O)N1CCC2(CC1)CN(C(=O)Nc1ccc(C(F)(F)F)cc1)CCO2";"IC50";"'='";"2.9";"nM";"8.54";"";"";"UO_0000065";"19.97";"0.39";"4.56";"13.80";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104621";"";"0";"481.90";"0";"4.90";"24";"O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccc(Cl)cc3)CC2)C1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"18.68";"0.37";"4.10";"14.54";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104616";"";"0";"497.46";"1";"5.41";"18";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCCN(C(=O)c3c(F)cccc3F)C2)CC1";"IC50";"'='";"2.96";"nM";"8.53";"";"";"UO_0000065";"17.14";"0.33";"3.12";"13.78";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3617998";"";"0";"580.54";"3";"-2.94";"7, aloinoside D";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@](O)([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"Inhibition";"'='";"108.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3620668";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde at 100 uM measured during 1 hr by fluorescence photometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL40275";"ALOE-EMODIN";"0";"270.24";"0";"1.37";"SID545430";"O=C1c2cccc(O)c2C(=O)c2c(O)cc(CO)cc21";"Ki";"'='";"52200.0";"nM";"4.28";"";"";"UO_0000065";"15.85";"0.29";"2.91";"4.52";"False";"CHEMBL3620670";"Non-competitive inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3617994";"";"0";"418.40";"1";"-0.89";"3";"O=C1c2c(O)cccc2[C@@H]([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cc(CO)cc(O)c21";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3620673";"Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3617998";"";"0";"580.54";"3";"-2.94";"7, aloinoside D";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@](O)([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3620673";"Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3222127";"";"0";"363.50";"0";"3.22";"7c";"CC(C)(C)OC(=O)N1CCN(C(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"490.0";"nM";"6.31";"";"";"UO_0000065";"17.36";"0.33";"3.09";"10.20";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL1818409";"";"0";"354.35";"0";"4.99";"29";"CC(CCc1ccccc1)NC(=O)Nc1cccc(C(F)(F)F)c1F";"IC50";"'='";"1.9";"nM";"8.72";"";"";"UO_0000065";"24.61";"0.48";"3.73";"21.20";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL464229";"";"0";"492.43";"2";"-0.62";"16";"COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc2c(c1O)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3633668";"";"0";"355.44";"0";"3.95";"3c";"O=C(NCc1cc(-c2ccco2)on1)NCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"4.9";"nM";"8.31";"";"";"UO_0000065";"23.38";"0.44";"4.36";"10.35";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3633671";"";"0";"331.46";"0";"3.81";"3f";"CC(C)c1cc(CNC(=O)NCC23CC4CC(CC(C4)C2)C3)on1";"IC50";"'='";"44.6";"nM";"7.35";"";"";"UO_0000065";"22.18";"0.42";"3.54";"10.95";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL2392698";"";"0";"452.48";"0";"2.79";"10h";"COCCNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.89";"0.38";"6.21";"9.75";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392712";"";"0";"423.44";"0";"2.51";"8a";"CNc1nc(NC)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"16.53";"0.32";"4.49";"7.36";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3617999";"";"0";"686.62";"3";"-0.01";"8";"O=C1c2cc(CO)cc(O)c2C(=O)c2c1ccc([C@]1([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3cccc(O)c3C(=O)c3c(O)cc(CO)cc31)c2O";"Inhibition";"'='";"93.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3620668";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde at 100 uM measured during 1 hr by fluorescence photometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3263302";"";"0";"498.76";"1";"5.57";"3d";"O=C(NCCCCCCCCNC(=O)NC1C2CC3CC(C2)CC1C3)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"4.1";"nM";"8.39";"";"";"UO_0000065";"16.82";"0.32";"2.82";"10.20";"False";"CHEMBL3270579";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3677973";"";"0";"466.46";"1";"5.27";"BDBM158479";"CCOC(=O)c1ccc(O[C@H]2CC[C@@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"3.4";"nM";"8.47";"";"301033";"UO_0000065";"18.15";"0.35";"3.20";"9.86";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL249447";"";"0";"516.46";"3";"1.03";"3";"O=C(/C=C/c1ccc(O)c(O)c1)O[C@@H]1C[C@](O)(C(=O)O)C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@H]1O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4010817";"Mixed type inhibition of sEH (unknown origin) at 0.78 to 6.25 uM using PHOME as substrate measured for 30 mins by Lineweaver-burk plot method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4090057";"";"0";"213.28";"0";"3.01";"5";"CC(C)=C/C=C1/C(=O)N(C)c2ccccc21";"Inhibition";"'='";"80.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4010815";"Inhibition of sEH (unknown origin) at 100 uM using PHOME as substrate after 40 mins by fluorescence photometric method relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL1076184";"CIMIRACEMATE A";"0";"358.35";"0";"2.18";"2";"COc1ccc(/C=C/C(=O)OCC(=O)Cc2ccc(O)c(O)c2)cc1O";"Inhibition";"'='";"103.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4010815";"Inhibition of sEH (unknown origin) at 100 uM using PHOME as substrate after 40 mins by fluorescence photometric method relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL45663";"";"0";"231.22";"0";"1.51";"Fragment 3";"FC(F)(F)c1cccnc1N1CCNCC1";"IC50";"'='";"1200000.0";"nM";"2.92";"";"";"UO_0000065";"12.63";"0.25";"1.41";"10.37";"False";"CHEMBL3406221";"Inhibition of C-terminal His6-tagged full-length human soluble epoxide hydrolase expressed in Escherichia coli BL21(DE3) cells pre-incubated for 15 mins before addition of PHOME substrate and measured 50 mins after substrate addition by microplate reader based fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400124";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3322819";"";"0";"441.68";"1";"5.77";"BDBM50057630";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCC1=NOS(=O)N1)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"423488";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1632479";"";"0";"498.67";"0";"4.71";"19b";"CC(C)(C)OC(=O)N1CCN(CCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"2.8";"nM";"8.55";"";"";"UO_0000065";"17.15";"0.32";"3.84";"10.29";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632487";"";"0";"580.80";"2";"5.25";"43";"Cc1ccc(S(=O)(=O)N2CCN(CCCCOc3cccc(NC(=O)NC45CC6CC(CC(C6)C4)C5)c3)CC2)cc1";"IC50";"'='";"3.3";"nM";"8.48";"";"";"UO_0000065";"14.60";"0.28";"3.23";"9.32";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL3808768";"";"0";"298.39";"0";"2.65";"8c(S)";"O=C(NCCCc1ccccc1)N[C@H](CO)c1ccccc1";"IC50";"'='";"19990.0";"nM";"4.70";"";"";"UO_0000065";"15.75";"0.29";"2.05";"7.66";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL2348397";"";"0";"305.31";"0";"2.20";"5h";"Cc1ccccc1S(=O)(=O)Oc1cccc2oc(=O)[nH]c12";"Inhibition";"'='";"28.02";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3765638";"";"0";"406.40";"0";"3.76";"21";"CON(C)C(=O)C1CC1c1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1";"IC50";"'='";"80.0";"nM";"7.10";"";"";"UO_0000065";"17.46";"0.33";"3.34";"12.10";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL2392688";"";"0";"340.43";"0";"1.75";"23";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392702";"";"0";"406.45";"0";"3.98";"14";"CNc1cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)cc(C)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3890626";"";"0";"488.82";"0";"4.30";"BDBM181785";"O=C(NCc1ccc(Cl)cc1Cl)N[C@H]1CCC12CN(S(=O)(=O)c1ccc(Cl)cc1)C2";"IC50";"'='";"678.0";"nM";"6.17";"";"328792";"UO_0000065";"12.62";"0.28";"1.87";"7.86";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4088942";"";"0";"312.37";"0";"4.33";"21";"CC(C)(C)c1ccc(NC(=O)Nc2ccc(C(=O)O)cc2)cc1";"IC50";"'='";"18500.0";"nM";"4.73";"";"";"UO_0000065";"15.15";"0.28";"0.40";"6.03";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4097715";"";"0";"283.33";"0";"2.93";"10";"Cc1ccc(C(=O)NCc2ccc(C(=O)O)cc2)cc1C";"Inhibition";"'='";"52.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL471650";"";"0";"540.35";"1";"4.64";"6-19";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2[N+](=O)[O-])CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512871";"";"0";"400.54";"0";"3.33";"8-9";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccccc3)CC2)c(C)c1";"Inhibition";"'='";"65.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL472285";"";"0";"397.33";"0";"4.22";"6-34";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(C(=O)c2cccs2)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL469793";"";"0";"401.53";"0";"2.72";"8-19";"Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)NCc3ccncc3)CC2)c(C)c1";"Inhibition";"'='";"49.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL999422";"Inhibition of epoxide hydrolase at 200 nm";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL527061";"";"0";"330.38";"0";"3.18";"27";"O=C(Nc1ccc(C(=O)O)c(O)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"71.0";"nM";"7.15";"";"";"UO_0000065";"21.64";"0.41";"3.97";"7.25";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"10.9";"nM";"7.96";"";"";"UO_0000065";"20.28";"0.39";"2.72";"10.15";"False";"CHEMBL3620669";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL48435";"";"0";"561.66";"2";"5.39";"4";"COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12";"IC50";"'='";"2500.0";"nM";"5.60";"";"";"UO_0000065";"9.97";"0.19";"0.21";"4.84";"False";"CHEMBL4256761";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by spectrofluorimetry";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4279086";"";"0";"574.70";"2";"5.35";"10";"COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12";"IC50";"'='";"43.0";"nM";"7.37";"";"";"UO_0000065";"12.82";"0.25";"2.02";"6.21";"False";"CHEMBL4256761";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by spectrofluorimetry";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL2180633";"";"0";"407.51";"0";"4.00";"6f";"O=C(NCc1ccc(Cn2cccc2C(=O)O)cc1)NC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3";"IC50";"'='";"73.0";"nM";"7.14";"";"";"UO_0000065";"17.51";"0.32";"3.14";"8.56";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL4214601";"";"0";"412.36";"0";"4.26";"9";"O=C(NCCCCOc1ccc(C(=O)O)cc1)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"18.97";"0.37";"3.56";"8.08";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL242459";"";"0";"412.53";"0";"4.34";"6";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"20.66";"0.39";"4.18";"9.72";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4211919";"";"0";"452.43";"1";"5.02";"20";"CC(=O)Oc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"18.56";"0.36";"3.38";"9.78";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1766296";"";"0";"494.54";"0";"4.91";"11h";"CC(C)(C)c1cc(CNC(=O)Nc2cccc(C(F)(F)F)c2)nn1-c1ccc(S(C)(=O)=O)cc1";"IC50";"'='";"32.0";"nM";"7.50";"";"";"UO_0000065";"15.16";"0.30";"2.58";"8.05";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1336";"SORAFENIB";"4";"464.83";"1";"5.55";"BAY 43-9006, Nexavar";"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"17.04";"0.34";"2.37";"8.58";"True";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3099592";"";"0";"244.29";"0";"2.29";"n";"O/N=C1C(=C\c2ccc(O)cc2)\N2CCC\1CC2";"Activity";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3102106";"Binding affinity to soluble epoxide hydrolase (unknown origin) at 400 uM by STD-NMR assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL2348408";"";"0";"255.23";"0";"2.34";"4a";"O=C(Oc1cccc2oc(=O)[nH]c12)c1ccccc1";"Inhibition";"'='";"28.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348189";"";"0";"289.67";"0";"2.99";"4c";"O=C(Oc1cccc2oc(=O)[nH]c12)c1cccc(Cl)c1";"Inhibition";"'='";"25.31";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348388";"";"0";"269.26";"0";"2.65";"4i";"Cc1cccc(C(=O)Oc2cccc3oc(=O)[nH]c23)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348191";"";"0";"300.23";"0";"2.25";"4e";"O=C(Oc1cccc2oc(=O)[nH]c12)c1ccccc1[N+](=O)[O-]";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2397148";"";"0";"438.40";"0";"4.80";"t-TUCB";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"20.75";"0.40";"4.30";"9.39";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1358";"FULVESTRANT";"4";"606.78";"2";"8.68";"15G10";"C[C@]12CC[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCCCC[S+]([O-])CCCC(F)(F)C(F)(F)F)[C@H]3[C@@H]1CC[C@@H]2O";"Activity";"'>'";"80.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2400590";"Reversible inhibition of human recombinant soluble epoxide hydrolase assessed as residual enzyme activity at 10 uM after 15 mins relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL397669";"";"0";"388.60";"1";"5.16";"127";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCC2CCCCC2)CC1";"IC50";"'='";"4.8";"nM";"8.32";"";"";"UO_0000065";"21.41";"0.41";"3.16";"16.52";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL3955973";"";"0";"440.35";"0";"3.21";"BDBM181771";"O=C(NCc1ccc(Cl)cc1Cl)N1CC2(C1)CN(S(=O)(=O)c1ccccc1)C2";"IC50";"'='";"79.0";"nM";"7.10";"";"328778";"UO_0000065";"16.13";"0.35";"3.89";"10.19";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4126127";"";"0";"460.76";"0";"4.24";"6b";"S=C(NCCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"97.6";"nM";"7.01";"";"";"UO_0000065";"15.22";"0.31";"2.77";"14.57";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4127203";"";"0";"344.57";"0";"4.24";"4a";"S=C(NC1C2CC3CC(C2)CC1C3)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"14.8";"nM";"7.83";"";"";"UO_0000065";"22.72";"0.45";"3.59";"32.54";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4129627";"";"0";"328.53";"0";"4.40";"1d";"CC12CC3CC(C)(C1)CC(NC(=S)NCc1ccccc1)(C3)C2";"IC50";"'='";"58.0";"nM";"7.24";"";"";"UO_0000065";"22.03";"0.43";"2.84";"30.08";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL2031806";"";"0";"320.82";"0";"4.14";"17, 77";"O=C(Nc1ccc(O)c(Cl)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"5.1";"nM";"8.29";"";"";"UO_0000065";"25.85";"0.51";"4.15";"13.51";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL592255";"";"0";"302.30";"0";"3.99";"8";"CC1CCCCN1C(=O)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"29.0";"nM";"7.54";"";"";"UO_0000065";"24.93";"0.49";"3.55";"18.13";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL32969";"";"0";"208.21";"0";"1.59";"7";"COC(=O)/C=C/c1ccc(O)c(OC)c1";"IC50";"'='";"1800.0";"nM";"5.75";"";"";"UO_0000065";"27.59";"0.52";"4.15";"10.30";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL565628";"";"0";"414.43";"0";"4.97";"15";"O=C(NCCC(c1ccccc1)c1ccccc1)c1ccc(OCC(F)(F)F)nc1";"IC50";"'='";"5.4";"nM";"8.27";"";"";"UO_0000065";"19.95";"0.38";"3.30";"16.14";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL572205";"";"0";"379.17";"0";"4.26";"14";"O=C(NCc1ccc(Cl)cc1Cl)c1ccc(OCC(F)(F)F)nc1";"IC50";"'='";"6.6";"nM";"8.18";"";"";"UO_0000065";"21.57";"0.47";"3.92";"15.97";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1818392";"";"0";"258.24";"0";"3.17";"9";"O=C(Nc1ccc(F)c(F)c1F)NC1CCCC1";"IC50";"'='";"56.2";"nM";"7.25";"";"";"UO_0000065";"28.08";"0.55";"4.08";"17.63";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL591555";"";"0";"262.35";"0";"1.91";"14";"Cc1ccc(CNC(=O)N2CCCC(CO)C2)cc1";"IC50";"'='";"2900.0";"nM";"5.54";"";"";"UO_0000065";"21.11";"0.40";"3.63";"10.53";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL4087558";"";"0";"283.33";"0";"2.93";"9";"Cc1ccc(C(=O)NCc2ccc(C(=O)O)cc2)c(C)c1";"Inhibition";"'='";"7.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4071682";"";"0";"344.32";"0";"2.25";"1";"COc1ccc(/C=C/C(=O)OCC(=O)c2ccc(O)c(O)c2)cc1O";"IC50";"'='";"1600.0";"nM";"5.80";"";"";"UO_0000065";"16.83";"0.32";"3.55";"5.12";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL1258447";"";"0";"293.34";"0";"2.35";"28";"CCC(=O)N1CCC(NC(=O)Nc2cccc(F)c2)CC1";"IC50";"'='";"39.0";"nM";"7.41";"";"";"UO_0000065";"25.26";"0.48";"5.06";"12.06";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL4093296";"";"0";"341.41";"0";"3.38";"25";"CC(C)(C)c1ccc(C(=O)NCc2ccc(OCC(=O)O)cc2)cc1";"IC50";"'='";"19000.0";"nM";"4.72";"";"";"UO_0000065";"13.83";"0.26";"1.34";"6.24";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL242459";"";"0";"412.53";"0";"4.34";"BDBM50217448";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"1.5";"nM";"8.82";"";"301032";"UO_0000065";"21.39";"0.40";"4.48";"10.07";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322798";"";"0";"486.65";"0";"2.65";"3";"CCCCNC(=O)C(=O)NCCCC/C=C\CCCCCCC(=O)OCCOCCOCCO";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL589374";"";"0";"445.34";"0";"4.28";"34";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(S(=O)(=O)c2ccc(F)cc2)CC1";"IC50";"'='";"39.0";"nM";"7.41";"";"";"UO_0000065";"16.64";"0.36";"3.13";"11.14";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL601094";"";"0";"262.35";"0";"1.91";"13";"Cc1cccc(CNC(=O)N2CCCC(CO)C2)c1";"IC50";"'>'";"3000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL3322810";"";"0";"381.59";"0";"4.67";"15";"CCCCCNC(=O)NCCCC/C=C\CCCCCSc1ncn[nH]1";"IC50";"'='";"32.0";"nM";"7.50";"";"";"UO_0000065";"19.64";"0.39";"2.82";"9.06";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL592740";"";"0";"447.28";"1";"5.98";"28";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(c2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"5.6";"nM";"8.25";"";"";"UO_0000065";"18.45";"0.39";"2.27";"19.85";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL608263";"";"0";"423.30";"0";"4.44";"47";"O=C(O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"EC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"20.72";"0.43";"4.33";"11.12";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL3099679";"";"0";"185.18";"0";"3.09";"x";"c1coc(-c2nc3ccccc3o2)c1";"IC50";"'='";"133000.0";"nM";"";"Outside typical range";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL3617997";"";"0";"534.51";"3";"-1.40";"6, aloinoside C";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@H]([C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"Inhibition";"'='";"87.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3620668";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde at 100 uM measured during 1 hr by fluorescence photometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3818683";"";"0";"573.08";"2";"6.20";"8c";"CCCCCCC(Sc1nc(Cl)cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1)C(=O)O";"IC50";"'='";"300.0";"nM";"6.52";"";"";"UO_0000065";"11.38";"0.23";"0.32";"6.84";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL2336735";"";"0";"268.74";"0";"2.58";"2";"O=C(Nc1ccc(Cl)cc1)N1CCC(CO)CC1";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2031949";"";"0";"419.61";"0";"3.30";"111, 131";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@H](OCCCN2CCOCC2)CC1";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"20.84";"0.40";"5.44";"13.92";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL419810";"";"0";"280.37";"0";"2.12";"3";"O=C(O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"684.0";"nM";"6.17";"";"";"UO_0000065";"21.99";"0.42";"4.04";"7.86";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL4217337";"";"0";"634.81";"2";"2.01";"18";"C[C@@H]1C[C@H]2O[C@@]3(O[C@H]2C(C)(C)O)[C@H](O)[C@@]2(C)C4=CC[C@H]5C(C)(C)[C@@H](O[C@@H]6OC[C@@H](O)[C@H](O)[C@H]6O)CC[C@@]56C[C@@]46C[C@@H](O)[C@]2(C)[C@@H]13";"Inhibition";"'='";"61.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4191389";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate at 100 uM measured for 1 hr by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4203466";"";"0";"432.35";"1";"5.72";"10";"O=C(Nc1ccc(Oc2ccc(C(=O)O)cc2)cc1)Nc1ccc(OC(F)(F)F)cc1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"18.86";"0.36";"2.43";"8.42";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4205324";"";"0";"486.48";"0";"4.18";"5f";"CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"17.88";"0.33";"4.52";"6.23";"False";"CHEMBL4190669";"Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate incubated for 5 mins followed by substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190176";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL3617995";"";"0";"402.40";"1";"-0.08";"4";"Cc1cc(O)c2c(c1)[C@H]([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)c1cccc(O)c1C2=O";"IC50";"'='";"15600.0";"nM";"4.81";"";"";"UO_0000065";"11.95";"0.23";"4.89";"3.25";"False";"CHEMBL3620669";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3617999";"";"0";"686.62";"3";"-0.01";"8";"O=C1c2cc(CO)cc(O)c2C(=O)c2c1ccc([C@]1([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3cccc(O)c3C(=O)c3c(O)cc(CO)cc31)c2O";"IC50";"'='";"4100.0";"nM";"5.39";"";"";"UO_0000065";"7.85";"0.15";"5.40";"2.05";"False";"CHEMBL3620669";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3617997";"";"0";"534.51";"3";"-1.40";"6, aloinoside C";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@H]([C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"Ki";"'='";"800.0";"nM";"6.10";"";"";"UO_0000065";"11.41";"0.22";"7.50";"2.95";"False";"CHEMBL3620670";"Non-competitive inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3617995";"";"0";"402.40";"1";"-0.08";"4";"Cc1cc(O)c2c(c1)[C@H]([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)c1cccc(O)c1C2=O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3620673";"Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3104439";"";"0";"425.45";"0";"3.73";"36";"O=C(CC1CC1)N1CCC2(CC1)CN(C(=O)Nc1ccc(C(F)(F)F)cc1)CCO2";"IC50";"'='";"2.1";"nM";"8.68";"";"";"UO_0000065";"20.40";"0.40";"4.95";"14.02";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL449392";"CORILAGIN";"0";"634.46";"3";"-0.30";"8";"O=C(O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL50";"QUERCETIN";"3";"302.24";"0";"1.99";"1";"O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL2397149";"";"0";"446.39";"0";"4.78";"22";"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"20.84";"0.40";"4.52";"9.16";"True";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL603531";"";"0";"436.36";"0";"2.08";"25";"CS(=O)(=O)CCNC(=O)C1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"'='";"230.0";"nM";"6.64";"";"";"UO_0000065";"15.21";"0.34";"4.56";"6.95";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL591556";"";"0";"248.33";"0";"1.60";"11";"O=C(NCc1ccccc1)N1CCCC(CO)C1";"IC50";"'>'";"3000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL591790";"";"0";"330.22";"0";"2.40";"20";"NC(=O)C1CCN(C(=O)NCc2ccc(Cl)cc2Cl)CC1";"IC50";"'='";"220.0";"nM";"6.66";"";"";"UO_0000065";"20.16";"0.43";"4.26";"8.83";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL4282716";"";"0";"548.54";"3";"-1.34";"2";"Cc1ccc2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3ccccc3c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2c1";"IC50";"'='";"300.0";"nM";"6.52";"";"";"UO_0000065";"11.89";"0.23";"7.86";"3.28";"False";"CHEMBL4269821";"Inhibition of soluble epoxide hydrolase (unknown origin) using NEPC as substrate after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4266023";"1";"Scientific Literature";"J Nat Prod";"2018";"None"
"CHEMBL1256164";"";"0";"281.40";"0";"2.02";"BDBM50327823";"CCC(=O)N1CCC(NC(=O)NC2CCCCC2)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"377007";"UO_0000065";"28.15";"0.54";"5.90";"12.89";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257514";"";"0";"311.47";"0";"3.05";"BDBM50327842";"CCCCCCCCNC(=O)NC1CCN(C(=O)CC)CC1";"IC50";"'='";"3.2";"nM";"8.49";"";"377008";"UO_0000065";"27.27";"0.53";"5.44";"13.83";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257515";"";"0";"315.42";"0";"2.24";"BDBM50327817";"CCC(=O)N1CCC(NC(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1";"IC50";"'='";"2.7";"nM";"8.57";"";"377009";"UO_0000065";"27.17";"0.51";"6.33";"13.95";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257633";"";"0";"289.38";"0";"2.52";"BDBM50327838";"CCC(=O)N1CCC(NC(=O)Nc2ccccc2C)CC1";"IC50";"'='";"1700.0";"nM";"5.77";"";"377013";"UO_0000065";"19.94";"0.38";"3.25";"9.39";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4095466";"";"0";"331.37";"0";"3.98";"12";"O=C(O)c1ccc(CNC(=O)c2cccc(-c3ccccc3)c2)cc1";"IC50";"'='";"10000.0";"nM";"5.00";"";"";"UO_0000065";"15.09";"0.27";"1.02";"7.53";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL3327076";"";"0";"323.48";"0";"3.05";"16";"CCC(C)C(=O)N1CCC(NC(=O)NC2CCCCCC2)CC1";"Ki";"'='";"0.99";"nM";"9.00";"";"";"UO_0000065";"27.84";"0.53";"5.95";"14.66";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3810377";"";"0";"234.34";"0";"2.72";"8j(S)";"CC[C@H](C)NC(=O)NCCCc1ccccc1";"IC50";"'='";"63.0";"nM";"7.20";"";"";"UO_0000065";"30.73";"0.58";"4.48";"17.51";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL4108921";"";"0";"483.34";"None";"None";"BDBM179754";"";"IC50";"'>'";"500.0";"nM";"";"";"326378";"UO_0000065";"";"";"";"";"False";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3558237";"";"0";"376.56";"0";"4.04";"BDBM179757";"CCCCCNC(=O)NCCCC/C=C\CCCCCCS(=O)(=O)O";"IC50";"'='";"57.0";"nM";"7.24";"";"326384";"UO_0000065";"19.24";"0.40";"3.20";"7.59";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4110025";"";"0";"492.33";"None";"None";"BDBM179762";"";"IC50";"'>'";"500.0";"nM";"";"";"326403";"UO_0000065";"";"";"";"";"False";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL2037374";"";"0";"269.30";"0";"3.82";"5";"COc1ccc(-c2nc3cc(C)ccc3o2)cc1OC";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2039369";"Inhibition of soluble epoxide hydrolase using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to substrate addition measured every min for 15 mins by fluorometry";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2034900";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None"
"CHEMBL3222117";"";"0";"424.55";"0";"3.08";"4b";"CC(=O)N1CCN(C(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1";"IC50";"'='";"9.0";"nM";"8.05";"";"";"UO_0000065";"18.95";"0.35";"4.97";"9.84";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3222120";"";"0";"505.66";"1";"4.26";"5b";"CC(=O)N1CCN(CCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c3cccnc23)CC1";"IC50";"'='";"142.0";"nM";"6.85";"";"";"UO_0000065";"13.54";"0.25";"2.59";"7.89";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3629066";"";"0";"504.65";"2";"6.61";"34";"CCOP(=O)(OCC)C(Nc1ccc(CCNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"8.2";"nM";"8.09";"";"";"UO_0000065";"16.02";"0.32";"1.48";"10.55";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628780";"";"0";"561.75";"2";"7.78";"27";"CC(C)COP(=O)(OCC(C)C)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"15.57";"0.31";"0.96";"9.86";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628410";"";"0";"524.64";"2";"7.20";"4";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)c1ccc(C)cc1";"IC50";"'='";"130.0";"nM";"6.89";"";"";"UO_0000065";"13.13";"0.25";"-0.31";"8.98";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3327082";"";"0";"379.40";"0";"2.64";"26";"CCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"1.74";"nM";"8.76";"";"";"UO_0000065";"23.09";"0.48";"6.12";"11.16";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1668925";"";"0";"307.44";"0";"2.27";"14d";"CC(=O)N1CCC(NC(=O)NC2CC3(C)CCC2CC3)CC1";"IC50";"'='";"25.0";"nM";"7.60";"";"";"UO_0000065";"24.73";"0.47";"5.33";"12.37";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668931";"";"0";"303.35";"0";"1.87";"14j";"CC(=O)N1CCC(NC(=O)NC2CCC(F)(F)CC2)CC1";"IC50";"'='";"185.0";"nM";"6.73";"";"";"UO_0000065";"22.19";"0.44";"4.86";"10.96";"False";"CHEMBL1671068";"Inhibition of human soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"None"
"CHEMBL1668929";"";"0";"323.48";"0";"2.90";"14h";"CC(=O)N1CCC(NC(=O)NC2CCC(C(C)(C)C)CC2)CC1";"IC50";"'='";"270.0";"nM";"6.57";"";"";"UO_0000065";"20.31";"0.39";"3.67";"10.69";"False";"CHEMBL1671070";"Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HUVEC";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1667772";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2011";"CHEMBL3307501"
"CHEMBL457032";"";"0";"439.43";"0";"4.33";"12k";"O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"18.43";"0.36";"3.77";"11.24";"True";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL549902";"";"0";"379.48";"0";"3.38";"13b";"O=C(Nc1ccc(F)c(OCCCN2CCOCC2)c1)NC1CCCCC1";"IC50";"'='";"6.5";"nM";"8.19";"";"";"UO_0000065";"21.57";"0.41";"4.81";"13.03";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL559929";"";"0";"388.90";"0";"3.62";"20l";"O=C(Cc1ccc(Cl)cc1)Nc1ccc(OCCCN2CCOCC2)cc1";"IC50";"'='";"140.0";"nM";"6.85";"";"";"UO_0000065";"17.62";"0.35";"3.23";"13.49";"False";"CHEMBL1062360";"Inhibition of human soluble epoxide hydrolase by fluorescent endpoint assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152369";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL2313172";"";"0";"416.50";"0";"3.04";"7-34";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(C(=O)O)cc3)CC2)c(C)c1";"IC50";"'='";"17.0";"nM";"7.77";"";"";"UO_0000065";"18.65";"0.37";"4.73";"7.49";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313198";"";"0";"440.49";"0";"4.36";"7-15";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(C(F)(F)F)cc3)CC2)c(C)c1";"IC50";"'='";"30.0";"nM";"7.52";"";"";"UO_0000065";"17.08";"0.34";"3.16";"11.32";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL4066332";"";"0";"394.92";"0";"3.94";"57";"CC(C)(C)c1ccc(C(=O)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"22.79";"0.47";"5.06";"11.96";"False";"CHEMBL4019484";"Inhibition of sEH in human HepG2 cells using 14(15)-EET-d11 as substrate assessed as reduction in conversion of 14(15)-EET-d11 to 14(15)-DHET-d11 preincubated for 15 mins followed by substrate addition measured after 10 mins LC-MS/MS analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL3402240";"";"0";"285.43";"0";"4.09";"9";"Oc1ccccc1CNCCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"510.0";"nM";"6.29";"";"";"UO_0000065";"22.05";"0.41";"2.20";"19.51";"False";"CHEMBL3406221";"Inhibition of C-terminal His6-tagged full-length human soluble epoxide hydrolase expressed in Escherichia coli BL21(DE3) cells pre-incubated for 15 mins before addition of PHOME substrate and measured 50 mins after substrate addition by microplate reader based fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400124";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL436774";"AR9281";"2";"319.45";"0";"2.27";"APAU";"CC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"T1/2";"'='";"0.1005";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1258904";"";"0";"359.35";"0";"3.11";"18, TPPU";"CCC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"Ki";"'='";"0.91";"nM";"9.04";"";"";"UO_0000065";"25.16";"0.49";"5.93";"12.79";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327074";"";"0";"387.40";"0";"3.74";"14";"CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"Ki";"'='";"0.36";"nM";"9.44";"";"";"UO_0000065";"24.38";"0.48";"5.70";"13.36";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1258106";"";"0";"320.35";"0";"2.12";"20";"CCC(=O)N1CCC(NC(=O)Nc2ccc([N+](=O)[O-])cc2)CC1";"IC50";"'='";"38.0";"nM";"7.42";"";"";"UO_0000065";"23.16";"0.44";"5.30";"7.10";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL568342";"";"0";"378.30";"0";"3.96";"10";"O=C(NCc1ccc(Cl)cc1Cl)c1ccc(CCN2CCCC2)nc1";"IC50";"'='";"1500.0";"nM";"5.82";"";"";"UO_0000065";"15.39";"0.32";"1.86";"12.88";"False";"CHEMBL1039073";"Inhibition of human soluble EH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156061";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3817950";"";"0";"462.51";"0";"4.89";"5c";"CCC(Cc1ccc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)cc1)C(=O)O";"IC50";"'='";"75.0";"nM";"7.12";"";"";"UO_0000065";"15.40";"0.29";"2.23";"10.23";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL2392720";"";"0";"277.39";"0";"3.23";"32";"O=C(Nc1nccs1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"83.0";"nM";"7.08";"";"";"UO_0000065";"25.53";"0.51";"3.85";"13.11";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392746";"";"0";"444.56";"0";"4.18";"12";"Cc1noc(NS(=O)(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)c1C";"IC50";"'='";"31.0";"nM";"7.51";"";"";"UO_0000065";"16.89";"0.33";"3.33";"6.63";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL3263298";"";"0";"610.97";"2";"8.41";"3c";"CCC(CNC(=O)NCCCCCCCCNC(=O)NCC(CC)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1440.0";"nM";"5.84";"";"";"UO_0000065";"9.56";"0.18";"-2.57";"7.10";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263289";"";"0";"498.76";"1";"5.58";"1c";"O=C(NCCCCCCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"18.36";"0.35";"3.57";"11.13";"False";"CHEMBL3270579";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263302";"";"0";"498.76";"1";"5.57";"3d";"O=C(NCCCCCCCCNC(=O)NC1C2CC3CC(C2)CC1C3)NC1C2CC3CC(C2)CC1C3";"Ratio IC50";"'='";"2.0";"";"";"";"";"";"";"";"";"";"False";"CHEMBL3270580";"Ratio of IC50 for recombinant human soluble epoxide hydrolase in presence of 1 mg/mL BSA to IC50 for recombinant human soluble epoxide hydrolase in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263303";"";"0";"328.50";"0";"4.22";"DAU";"O=C(NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1.3";"nM";"8.89";"";"";"UO_0000065";"27.05";"0.51";"4.67";"21.60";"False";"CHEMBL3270579";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3104440";"";"0";"469.50";"0";"4.39";"37";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)C3CCCCC3)CC2)C1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"19.64";"0.38";"4.83";"12.97";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL2031796";"";"0";"472.63";"0";"4.37";"9";"CCOCCOCC(OC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2)c1ccccc1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"17.77";"0.34";"4.03";"9.78";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL2070333";"";"0";"418.62";"1";"5.33";"12";"CCCCC(CC)OC(=O)C1CCCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)C1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"20.36";"0.39";"3.19";"12.64";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL2348187";"";"0";"313.26";"0";"-1.70";"6b";"O=c1[nH]c2c(O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)cccc2o1";"Inhibition";"'='";"60.98";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348392";"";"0";"325.73";"0";"2.54";"5c";"O=c1[nH]c2c(OS(=O)(=O)c3cccc(Cl)c3)cccc2o1";"Inhibition";"'='";"24.49";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3114605";"";"0";"380.44";"0";"3.49";"34";"O=C(O)c1cccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)c1";"IC50";"'>'";"100.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114609";"";"0";"414.89";"0";"4.15";"37";"O=C(O)c1ccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)c(Cl)c1";"IC50";"'='";"2.6";"nM";"8.59";"";"";"UO_0000065";"20.69";"0.40";"4.44";"10.89";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL2336313";"";"0";"555.60";"2";"6.75";"8k";"COc1cc(-c2nc3ccc(C)cn3c2NC(C)C)ccc1OCCCNC(=O)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"201.0";"nM";"6.70";"";"";"UO_0000065";"12.05";"0.23";"-0.05";"7.53";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL3263297";"";"0";"554.86";"2";"7.14";"3b";"CC(NC(=O)NCCCCCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"T1/2";"'='";"0.1833";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3270576";"Displacement of ACPU from recombinant human soluble epoxide hydrolase assessed as compound residence time after 1.5 hrs by FRET assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1257634";"";"0";"381.38";"0";"2.13";"1709, TUPS";"CS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"2.9";"nM";"8.54";"";"";"UO_0000065";"22.39";"0.47";"6.41";"9.73";"True";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1258904";"";"0";"359.35";"0";"3.11";"1770, TPPU";"CCC(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"3.7";"nM";"8.43";"";"";"UO_0000065";"23.46";"0.46";"5.32";"11.93";"True";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL4207503";"";"0";"636.82";"2";"2.00";"5";"C[C@@H]1C[C@H]([C@@H](O)C(C)(C)O)O[C@]2(O)[C@H]1[C@@]1(C)CC[C@@]34C[C@@]35CC[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]2O";"Inhibition";"'='";"84.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4191389";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate at 100 uM measured for 1 hr by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL374322";"";"0";"386.51";"0";"4.78";"63, 119, 130";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](Oc2ccc(F)cc2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"24.31";"0.46";"4.62";"18.66";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1087723";"";"0";"471.50";"0";"3.85";"13b, meta isomer";"O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(S(=O)(=O)CCCN2CCOCC2)c1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.09";"0.38";"5.15";"10.26";"False";"CHEMBL1103913";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1157924";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL592742";"";"0";"457.38";"0";"4.15";"44";"CS(=O)(=O)c1ccc(OC2CCN(C(=O)NCc3ccc(Cl)cc3Cl)CC2)cc1";"EC50";"'='";"0.97";"nM";"9.01";"";"";"UO_0000065";"19.71";"0.42";"4.86";"11.90";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2348395";"";"0";"336.28";"0";"1.80";"5f";"O=c1[nH]c2c(OS(=O)(=O)c3cccc([N+](=O)[O-])c3)cccc2o1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348390";"";"0";"291.28";"0";"1.89";"5a";"O=c1[nH]c2c(OS(=O)(=O)c3ccccc3)cccc2o1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348193";"";"0";"300.23";"0";"2.25";"4g";"O=C(Oc1cccc2oc(=O)[nH]c12)c1ccc([N+](=O)[O-])cc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL590106";"";"0";"397.28";"0";"4.89";"36";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ccc(F)cc2)CC1";"IC50";"'='";"6.1";"nM";"8.21";"";"";"UO_0000065";"20.68";"0.43";"3.32";"19.76";"False";"CHEMBL1074708";"Displacement of rhodamine-labeled probe from human soluble epoxide hydrolase by fluorescence polarization assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL2397148";"";"0";"438.40";"0";"4.80";"12, t-TUCB";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"0.9";"nM";"9.05";"";"";"UO_0000065";"20.63";"0.40";"4.25";"9.34";"True";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3629067";"";"0";"504.65";"2";"6.75";"35";"CCOP(=O)(OCC)C(Nc1ccc(CCC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"43.0";"nM";"7.37";"";"";"UO_0000065";"14.60";"0.29";"0.62";"9.61";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL1766284";"";"0";"533.70";"1";"4.39";"21f";"NS(=O)(=O)c1ccc(-n2nc(CCCNC(=O)NC34CC5CC(CC(C5)C3)C4)cc2-c2ccccc2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"17.43";"0.33";"4.91";"7.81";"False";"CHEMBL1768321";"Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1765073";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL4103131";"";"0";"380.37";"0";"3.91";"8";"COc1ccc(CNC(=O)c2ccc(C)c(NC(C)=O)c2)c(C(F)(F)F)c1";"IC50";"'='";"13.0";"nM";"7.89";"";"";"UO_0000065";"20.73";"0.40";"3.98";"11.70";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL1802692";"";"0";"354.49";"0";"3.17";"21";"CNC(=O)C(=O)NCCCC/C=C\CCCCCCCCCC(=O)O";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1804588";"Inhibition of soluble epoxide hydrolase at 5 uM";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1799995";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL1632453";"";"0";"412.58";"0";"3.45";"24a";"O=C(Nc1ccccc1OCCCN1CCNCC1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"97460.0";"nM";"4.01";"";"";"UO_0000065";"9.72";"0.18";"0.56";"6.11";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632467";"";"0";"440.63";"0";"4.18";"17c";"CN1CCN(CCCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1";"IC50";"'='";"44.8";"nM";"7.35";"";"";"UO_0000065";"16.68";"0.31";"3.17";"12.93";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632469";"";"0";"440.59";"0";"3.37";"36";"O=C(Nc1cccc(OCCCC(=O)N2CCNCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"91.4";"nM";"7.04";"";"";"UO_0000065";"15.98";"0.30";"3.67";"8.51";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632472";"";"0";"482.63";"0";"3.63";"37";"CC(=O)N1CCN(C(=O)CCCOc2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"5.4";"nM";"8.27";"";"";"UO_0000065";"17.13";"0.32";"4.64";"9.09";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1632474";"";"0";"440.63";"0";"4.23";"26b";"O=C(Nc1cccc(OCCCCCN2CCNCC2)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"13.8";"nM";"7.86";"";"";"UO_0000065";"17.84";"0.34";"3.63";"11.98";"False";"CHEMBL1634184";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1629536";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL3222112";"";"0";"396.58";"0";"2.82";"1";"O=C(NCC[C@H]1CN[C@@H](Cc2ccccc2)CN1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1370.0";"nM";"5.86";"";"";"UO_0000065";"14.78";"0.28";"3.04";"8.99";"False";"CHEMBL3223382";"Inhibition of soluble epoxide hydrolase (unknown origin)";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3905049";"";"0";"489.90";"0";"3.60";"BDBM181780";"O=C(NCc1ccccc1OC(F)(F)F)N1CC2(CCN2S(=O)(=O)c2ccc(Cl)cc2)C1";"IC50";"'='";"243.0";"nM";"6.61";"";"328787";"UO_0000065";"13.50";"0.28";"3.01";"8.38";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL497001";"ALOIN";"0";"418.40";"1";"-0.89";"2";"O=C1c2c(O)cccc2C([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cc(CO)cc(O)c21";"Ki";"'='";"57300.0";"nM";"4.24";"";"";"UO_0000065";"10.14";"0.19";"5.13";"2.53";"False";"CHEMBL3620671";"Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Dixon plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL469763";"";"0";"472.35";"0";"3.62";"6-4";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2cccc([N+](=O)[O-])c2)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL512005";"";"0";"512.28";"1";"4.53";"6-6";"O=C(NCc1ccc(Cl)cc1Cl)C1CCN(S(=O)(=O)c2ccc(Br)s2)CC1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL999421";"Inhibition of epoxide hydrolase";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153996";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL3222130";"";"0";"525.73";"2";"5.94";"8c";"CC(C)(C)OC(=O)N1CCN(CCCCOc2cccc(NC(=O)CC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"17.88";"0.34";"3.46";"13.22";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3222115";"";"0";"482.63";"0";"4.47";"3c";"CC(C)(C)OC(=O)N1CCN(C(=O)c2cccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"7.3";"nM";"8.14";"";"";"UO_0000065";"16.86";"0.32";"3.67";"8.94";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL1594316";"";"0";"224.26";"0";"3.01";"g";"COc1ccc(-c2cn3ccccc3n2)cc1";"Activity";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3102106";"Binding affinity to soluble epoxide hydrolase (unknown origin) at 400 uM by STD-NMR assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL3099591";"";"0";"244.17";"0";"2.82";"m";"COc1ccc2c(=O)cc(C(F)(F)F)oc2c1";"IC50";"'='";"91000.0";"nM";"4.04";"";"";"UO_0000065";"16.55";"0.32";"1.22";"10.25";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL3322810";"";"0";"381.59";"0";"4.67";"BDBM50057481";"CCCCCNC(=O)NCCCC/C=C\CCCCCSc1ncn[nH]1";"IC50";"'='";"32.0";"nM";"7.50";"";"326389";"UO_0000065";"19.64";"0.39";"2.82";"9.06";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4114588";"";"0";"486.37";"None";"None";"BDBM179760";"";"IC50";"'>'";"500.0";"nM";"";"";"326399";"UO_0000065";"";"";"";"";"False";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322821";"";"0";"396.60";"1";"5.44";"BDBM50057633";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1noc(=S)[nH]1";"IC50";"'='";"31.0";"nM";"7.51";"";"326401";"UO_0000065";"18.93";"0.38";"2.07";"9.05";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322824";"";"0";"446.62";"1";"5.24";"BDBM50057636";"CCCCCNC(=O)NCCCC/C=C\CCOc1cccc2sc(NC(C)=O)nc12";"IC50";"'='";"282.0";"nM";"6.55";"";"326406";"UO_0000065";"14.67";"0.29";"1.31";"7.09";"False";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3895811";"";"0";"378.26";"0";"2.82";"BDBM181772";"O=C(NCc1ccc(Cl)cc1Cl)N1CC2(C1)CN(c1ncccn1)C2";"IC50";"'='";"2323.0";"nM";"5.63";"";"328779";"UO_0000065";"14.89";"0.31";"2.81";"9.18";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3103801";"";"0";"314.38";"0";"2.04";"7";"O=C(NOc1ccccc1)C(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL2392708";"";"0";"370.46";"0";"1.76";"20";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3OC)CC2)n1";"IC50";"'='";"1600.0";"nM";"5.80";"";"";"UO_0000065";"15.65";"0.29";"4.04";"6.28";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392741";"";"0";"461.98";"0";"4.02";"7";"O=C(Nc1ccc(S(=O)(=O)Nc2ccc(Cl)nn2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"19.0";"nM";"7.72";"";"";"UO_0000065";"16.71";"0.34";"3.70";"6.83";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392712";"";"0";"423.44";"0";"2.51";"8a";"CNc1nc(NC)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"20.0";"nM";"7.70";"";"";"UO_0000065";"18.18";"0.35";"5.19";"8.10";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392709";"";"0";"424.43";"0";"2.65";"21";"CNc1nc(C)nc(N2CCC(C(=O)NCc3cccc(OC(F)(F)F)c3)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1458";"1,3-DICYCLOHEXYLUREA";"0";"224.35";"0";"2.95";"DCU";"O=C(NC1CCCCC1)NC1CCCCC1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"37.99";"0.73";"5.57";"20.72";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263302";"";"0";"498.76";"1";"5.57";"3d";"O=C(NCCCCCCCCNC(=O)NC1C2CC3CC(C2)CC1C3)NC1C2CC3CC(C2)CC1C3";"Ki";"'='";"2.4";"nM";"8.62";"";"";"UO_0000065";"17.28";"0.33";"3.05";"10.48";"False";"CHEMBL3270577";"Displacement of ACPU from recombinant human soluble epoxide hydrolase after 1.5 hrs by FRET assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263302";"";"0";"498.76";"1";"5.57";"3d";"O=C(NCCCCCCCCNC(=O)NC1C2CC3CC(C2)CC1C3)NC1C2CC3CC(C2)CC1C3";"T1/2";"'='";"0.04167";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3270576";"Displacement of ACPU from recombinant human soluble epoxide hydrolase assessed as compound residence time after 1.5 hrs by FRET assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263294";"";"0";"498.76";"1";"5.57";"2b";"CC(NC(=O)NCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"Ratio IC50";"'='";"2.0";"";"";"";"";"";"";"";"";"";"False";"CHEMBL3270580";"Ratio of IC50 for recombinant human soluble epoxide hydrolase in presence of 1 mg/mL BSA to IC50 for recombinant human soluble epoxide hydrolase in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263297";"";"0";"554.86";"2";"7.14";"3b";"CC(NC(=O)NCCCCCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"Ratio IC50";"'='";"2.0";"";"";"";"";"";"";"";"";"";"False";"CHEMBL3270580";"Ratio of IC50 for recombinant human soluble epoxide hydrolase in presence of 1 mg/mL BSA to IC50 for recombinant human soluble epoxide hydrolase in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1458";"1,3-DICYCLOHEXYLUREA";"0";"224.35";"0";"2.95";"DCU";"O=C(NC1CCCCC1)NC1CCCCC1";"IC50";"'='";"5.1";"nM";"8.29";"";"";"UO_0000065";"36.96";"0.71";"5.34";"20.16";"False";"CHEMBL3270579";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL2392691";"";"0";"438.45";"0";"2.78";"26";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(OC)cc3C(F)(F)F)CC2)n1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"19.84";"0.38";"5.92";"9.43";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392690";"";"0";"426.42";"0";"2.91";"25";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccc(F)cc3C(F)(F)F)CC2)n1";"IC50";"'='";"50.0";"nM";"7.30";"";"";"UO_0000065";"17.12";"0.33";"4.39";"8.79";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392704";"";"0";"406.45";"0";"3.98";"16";"CNc1cc(C)cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"100.0";"nM";"7.00";"";"";"UO_0000065";"17.22";"0.33";"3.02";"12.22";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392697";"";"0";"464.49";"0";"2.57";"10g";"Cc1nc(N2CCOCC2)nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"18.35";"0.35";"5.95";"10.21";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3322816";"";"0";"378.52";"0";"2.45";"BDBM50057502";"CCCCNC(=O)C(=O)NCCCC/C=C\CCCCCCc1nnn[nH]1";"IC50";"'>'";"500.0";"nM";"";"";"423475";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL224357";"";"0";"406.61";"1";"5.33";"2";"COC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.3";"nM";"8.64";"";"";"UO_0000065";"21.24";"0.41";"3.31";"12.81";"False";"CHEMBL918225";"Inhibition of human soluble epoxide hydrolase by fluorescent based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1144497";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2007";"None"
"CHEMBL231584";"";"0";"256.35";"0";"0.89";"39";"O=C(N[C@H]1CC[C@H](O)CC1)N[C@H]1CC[C@H](O)CC1";"IC50";"'='";"1400.0";"nM";"5.85";"";"";"UO_0000065";"22.84";"0.44";"4.96";"7.17";"False";"CHEMBL894930";"Inhibition of human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL436774";"AR9281";"2";"319.45";"0";"2.27";"APAU";"CC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"24.49";"0.46";"5.55";"12.73";"False";"CHEMBL894939";"Inhibition of human sEH by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1148702";"1";"Scientific Literature";"J. Med. Chem.";"2007";"None"
"CHEMBL1632490";"";"0";"512.70";"2";"5.10";"82";"CC(C)(C)OC(=O)N1CCN(CCCOc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1";"IC50";"'='";"14.6";"nM";"7.84";"";"";"UO_0000065";"15.28";"0.29";"2.74";"9.42";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031931";"";"0";"302.30";"0";"4.04";"85";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCCCC1";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"30.09";"0.59";"5.06";"18.06";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031935";"";"0";"484.51";"0";"3.56";"92";"COC(=O)c1ccc(NC(=O)N[C@H]2CC[C@@H](Oc3cc(C(=O)OC)cc(C(=O)OC)c3)CC2)cc1";"IC50";"'='";"3.8";"nM";"8.42";"";"";"UO_0000065";"17.38";"0.33";"4.86";"6.51";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL242655";"";"0";"396.57";"0";"3.49";"104";"CCOCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"14.1";"nM";"7.85";"";"";"UO_0000065";"19.80";"0.38";"4.36";"11.41";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL3322807";"";"0";"406.64";"1";"6.26";"12";"CCCCCNC(=O)NCCCC/C=C\CCCCCSc1ccccc1O";"IC50";"'='";"6.0";"nM";"8.22";"";"";"UO_0000065";"20.22";"0.40";"1.96";"13.40";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322799";"";"0";"438.65";"1";"5.46";"4";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCC(=O)NCC(=O)O)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL2031932";"";"0";"302.46";"1";"5.26";"86";"CCCCCCc1ccc(NC(=O)NC2CCCCC2)cc1";"IC50";"'='";"1.8";"nM";"8.74";"";"";"UO_0000065";"28.91";"0.54";"3.48";"21.26";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031944";"";"0";"338.49";"0";"3.09";"103";"COCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"12.1";"nM";"7.92";"";"";"UO_0000065";"23.39";"0.45";"4.83";"13.29";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2031789";"";"0";"374.57";"0";"4.91";"117";"O=C(NC12CC3CC(CC(C3)C1)C2)N[C@H]1CC[C@@H](OC2CCCCC2)CC1";"IC50";"'='";"1.6";"nM";"8.80";"";"";"UO_0000065";"23.48";"0.44";"3.89";"17.47";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL1360431";"";"0";"260.38";"0";"4.26";"83";"CC(C)c1ccc(NC(=O)NC2CCCCC2)cc1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"33.68";"0.63";"4.51";"21.32";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL3928540";"";"0";"470.88";"0";"4.63";"BDBM158488";"CNC(=O)c1cc(OC2CCC(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"301043";"UO_0000065";"19.75";"0.40";"4.67";"10.07";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4066332";"";"0";"394.92";"0";"3.94";"57";"CC(C)(C)c1ccc(C(=O)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1";"Inhibition";"'='";"17.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019482";"Inhibition of sEH in human HepG2 cells assessed as NF-kappaB mRNA expression at 1 uM after 8 to 16 hrs by SYBR green based qRT-PCR analysis relative to DMSO control";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL384467";"DEXAMETHASONE";"4";"392.47";"0";"1.90";"Dexamethasone";"C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO";"Inhibition";"'='";"59.4";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019482";"Inhibition of sEH in human HepG2 cells assessed as NF-kappaB mRNA expression at 1 uM after 8 to 16 hrs by SYBR green based qRT-PCR analysis relative to DMSO control";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL2032045";"";"0";"433.98";"0";"4.14";"141";"O=C(Nc1ccc(OCCN2CCOCC2)c(Cl)c1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"21.25";"0.42";"5.08";"14.68";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2032046";"";"0";"433.98";"0";"4.14";"142";"O=C(Nc1ccc(OCCN2CCOCC2)cc1Cl)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.4";"nM";"8.62";"";"";"UO_0000065";"19.86";"0.39";"4.48";"13.72";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL589136";"";"0";"381.26";"0";"3.54";"33";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC(Oc2ncccn2)CC1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"20.52";"0.43";"4.28";"11.62";"False";"CHEMBL1074709";"Inhibition of human soluble epoxide hydrolase in human HepG cells assessed as conversion of epoxyeicosatienoic acid to dihydroxyeicosatrienoic acid after 30 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153202";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2010";"None"
"CHEMBL4209701";"";"0";"437.45";"0";"2.82";"4";"CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)CCC(=O)O)cc1";"IC50";"'='";"2.22";"nM";"8.65";"";"";"UO_0000065";"19.78";"0.37";"5.83";"6.47";"False";"CHEMBL4190669";"Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate incubated for 5 mins followed by substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190176";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL3263294";"";"0";"498.76";"1";"5.57";"2b";"CC(NC(=O)NCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.5";"nM";"8.60";"";"";"UO_0000065";"17.25";"0.33";"3.03";"10.46";"False";"CHEMBL3270579";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL518177";"";"0";"440.58";"0";"3.90";"17b";"O=C(CC12CC3CC(CC(C3)C1)C2)C(=O)Nc1cccc(OCCCN2CCOCC2)c1";"IC50";"'='";"49.0";"nM";"7.31";"";"";"UO_0000065";"16.59";"0.31";"3.41";"10.77";"False";"CHEMBL1028131";"Inhibition of soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1152719";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL1257169";"";"0";"408.38";"0";"3.41";"47";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)c2ccncc2)CC1";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"22.42";"0.43";"5.74";"10.96";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1257286";"";"0";"519.57";"1";"3.52";"50";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CN2CCN(Cc3ccccc3)CC2)CC1";"IC50";"'='";"1.5";"nM";"8.82";"";"";"UO_0000065";"16.98";"0.33";"5.30";"11.44";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL1258557";"";"0";"344.24";"0";"3.52";"32";"CCC(=O)N1CCC(NC(=O)Nc2ccc(Cl)c(Cl)c2)CC1";"IC50";"'='";"3.4";"nM";"8.47";"";"";"UO_0000065";"24.60";"0.53";"4.95";"13.78";"True";"CHEMBL1259736";"Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1255168";"1";"Scientific Literature";"J. Med. Chem.";"2010";"None"
"CHEMBL3099592";"";"0";"244.29";"0";"2.29";"n";"O/N=C1C(=C\c2ccc(O)cc2)\N2CCC\1CC2";"IC50";"'='";"95000.0";"nM";"4.02";"";"";"UO_0000065";"16.47";"0.31";"1.73";"7.17";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL3114599";"";"0";"366.46";"0";"3.80";"21";"COc1cccc(OC2CCN(C(=O)N[C@H]3C[C@@H]3c3ccccc3)CC2)c1";"IC50";"'='";"7.4";"nM";"8.13";"";"";"UO_0000065";"22.19";"0.41";"4.33";"16.01";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3236512";"";"0";"292.20";"0";"0.66";"22";"O=C1C[C@H](C(=O)O)c2c1oc(=O)c1cc(O)c(O)c(O)c21";"IC50";"'='";"47360.0";"nM";"4.33";"";"";"UO_0000065";"14.80";"0.28";"3.66";"2.98";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263302";"";"0";"498.76";"1";"5.57";"3d";"O=C(NCCCCCCCCNC(=O)NC1C2CC3CC(C2)CC1C3)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"2.6";"nM";"8.59";"";"";"UO_0000065";"17.21";"0.33";"3.02";"10.44";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3322815";"";"0";"378.57";"0";"4.30";"BDBM50057497";"CCCCCNC(=O)NCCCC/C=C\CCCCCCCc1nnn[nH]1";"IC50";"'='";"32.0";"nM";"7.50";"";"326395";"UO_0000065";"19.80";"0.38";"3.19";"7.84";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3941817";"";"0";"474.80";"0";"4.01";"BDBM181774";"O=C(NCc1ccc(Cl)cc1Cl)N1CCC12CN(S(=O)(=O)c1ccc(Cl)cc1)C2";"IC50";"'='";"321.0";"nM";"6.49";"";"328781";"UO_0000065";"13.68";"0.31";"2.48";"9.31";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3964558";"";"0";"404.30";"0";"3.66";"BDBM181769";"O=C(NCc1ccc(Cl)cc1Cl)N1CC2(C1)CN(C(=O)c1ccccc1)C2";"IC50";"'='";"241.0";"nM";"6.62";"";"328776";"UO_0000065";"16.37";"0.33";"2.96";"12.57";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4072573";"";"0";"339.44";"0";"3.93";"24";"CC(C)(C)c1ccc(C(=O)NCc2ccc(CCC(=O)O)cc2)cc1";"IC50";"'='";"1630.0";"nM";"5.79";"";"";"UO_0000065";"17.05";"0.32";"1.86";"8.72";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL2313182";"";"0";"423.54";"0";"3.89";"7-44";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3cccc4cnccc34)CC2)c(C)c1";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"18.03";"0.35";"3.75";"9.62";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313200";"";"0";"406.94";"0";"4.00";"7-17";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(Cl)cc3)CC2)c(C)c1";"IC50";"'='";"2200.0";"nM";"5.66";"";"";"UO_0000065";"13.90";"0.29";"1.66";"8.51";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313199";"";"0";"440.49";"0";"4.36";"7-16";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3cccc(C(F)(F)F)c3)CC2)c(C)c1";"IC50";"'='";"640.0";"nM";"6.19";"";"";"UO_0000065";"14.06";"0.28";"1.83";"9.32";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3103799";"";"0";"342.44";"0";"2.57";"5";"O=C(NCC12CC3CC(CC(C3)C1)C2)C(=O)NOCc1ccccc1";"IC50";"'='";"838.0";"nM";"6.08";"";"";"UO_0000065";"17.75";"0.33";"3.51";"9.01";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3103821";"";"0";"428.53";"0";"2.44";"31";"CON(C)C(=O)C(=O)N(C)c1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"20.82";"0.39";"6.48";"9.81";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL2392699";"";"0";"407.44";"0";"3.38";"11";"CNc1nc(C)cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392702";"";"0";"406.45";"0";"3.98";"14";"CNc1cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)cc(C)n1";"IC50";"'='";"126.0";"nM";"6.90";"";"";"UO_0000065";"16.98";"0.32";"2.92";"12.05";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392701";"";"0";"407.44";"0";"3.38";"13";"CNc1cc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)nc(C)n1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"20.37";"0.39";"4.92";"11.83";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2392759";"";"0";"289.38";"0";"2.75";"26";"Cc1cc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)no1";"IC50";"'='";"1551.0";"nM";"5.81";"";"";"UO_0000065";"20.08";"0.38";"3.06";"8.65";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL1346880";"";"0";"271.36";"0";"3.17";"16";"O=C(Nc1ccccn1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1498.0";"nM";"5.82";"";"";"UO_0000065";"21.46";"0.40";"2.65";"10.78";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL497001";"ALOIN";"0";"418.40";"1";"-0.89";"2";"O=C1c2c(O)cccc2C([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cc(CO)cc(O)c21";"IC50";"'='";"37400.0";"nM";"4.43";"";"";"UO_0000065";"10.58";"0.20";"5.32";"2.64";"False";"CHEMBL3620669";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3765627";"";"0";"377.36";"0";"4.51";"15d";"CC/C(=C\c1cccc(C(=O)NCc2ccccc2C(F)(F)F)c1)C(=O)O";"IC50";"'='";"400.0";"nM";"6.40";"";"";"UO_0000065";"16.95";"0.32";"1.89";"9.64";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3765160";"";"0";"353.46";"0";"4.06";"3b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccccc2C)cc1";"IC50";"'='";"900.0";"nM";"6.05";"";"";"UO_0000065";"17.10";"0.32";"1.99";"10.91";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3322800";"";"0";"425.61";"0";"4.43";"5";"CCCCCN(C)C(=O)N(C)CCCC/C=C\CCCCCCC(=O)NCC(=O)O";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL4071682";"";"0";"344.32";"0";"2.25";"1";"COc1ccc(/C=C/C(=O)OCC(=O)c2ccc(O)c(O)c2)cc1O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL51085";"EBSELEN";"2";"274.18";"None";"None";"SID56422439";"O=c1c2ccccc2[se]n1-c1ccccc1";"IC50";"'='";"2200.0";"nM";"5.66";"";"";"UO_0000065";"20.63";"None";"None";"None";"False";"CHEMBL2400592";"Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonate) as substrate preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL354676";"DIPHENYLUREA";"0";"212.25";"0";"3.33";"5";"O=C(Nc1ccccc1)Nc1ccccc1";"IC50";"'='";"400.0";"nM";"6.40";"";"";"UO_0000065";"30.14";"0.55";"3.07";"15.56";"False";"CHEMBL2400592";"Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonate) as substrate preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL190496";"";"0";"230.33";"0";"3.14";"1";"[O-][S+](Cc1ccccc1)Cc1ccccc1";"IC50";"'='";"70000.0";"nM";"4.16";"";"";"UO_0000065";"18.04";"0.35";"1.01";"24.34";"False";"CHEMBL2400592";"Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonate) as substrate preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1257405";"";"0";"371.36";"0";"3.11";"CPTU";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)C2CC2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"25.31";"0.49";"6.29";"13.30";"True";"CHEMBL3223382";"Inhibition of soluble epoxide hydrolase (unknown origin)";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3322813";"";"0";"405.63";"1";"5.63";"18";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCc1nnn[nH]1)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3818107";"";"0";"390.87";"0";"4.03";"3b";"CCOC(=O)C(C)Oc1ccc(CCNC(=O)Nc2ccc(Cl)cc2)cc1";"IC50";"'='";"27.0";"nM";"7.57";"";"";"UO_0000065";"19.36";"0.38";"3.54";"9.87";"False";"CHEMBL3821236";"Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3817847";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL4076274";"";"0";"325.41";"0";"3.92";"29";"Cc1cc(C(=O)O)ccc1CNC(=O)c1ccc(C(C)(C)C)cc1";"IC50";"'='";"680.0";"nM";"6.17";"";"";"UO_0000065";"18.95";"0.35";"2.25";"9.29";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4076701";"";"0";"309.41";"0";"4.12";"35";"CC(=O)c1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)cc1";"IC50";"'='";"157.0";"nM";"6.80";"";"";"UO_0000065";"21.99";"0.40";"2.68";"14.74";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4083383";"";"0";"292.38";"0";"3.79";"36";"CC(C)(C)c1ccc(C(=O)NCc2ccc(C#N)cc2)cc1";"IC50";"'='";"910.0";"nM";"6.04";"";"";"UO_0000065";"20.66";"0.38";"2.25";"11.42";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4102626";"";"0";"345.46";"0";"3.32";"53";"CC(C)(C)c1ccc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"17.14";"0.34";"2.60";"9.36";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4066332";"";"0";"394.92";"0";"3.94";"57";"CC(C)(C)c1ccc(C(=O)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1";"IC50";"'='";"4.1";"nM";"8.39";"";"";"UO_0000065";"21.24";"0.44";"4.45";"11.14";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4095371";"";"0";"316.83";"0";"4.15";"69a";"CC(C)(C)c1ccc(C(=O)NCc2ccc(N)cc2Cl)cc1";"IC50";"'='";"40.0";"nM";"7.40";"";"";"UO_0000065";"23.35";"0.46";"3.25";"13.42";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4079681";"";"0";"331.37";"0";"3.98";"11";"O=C(O)c1ccc(CNC(=O)c2ccccc2-c2ccccc2)cc1";"Inhibition";"'='";"19.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL1231797";"";"0";"344.20";"0";"3.75";"2b";"O=C(Nc1ccc(I)cc1)NC1CCCCC1";"Inhibition";"'='";"22.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019483";"Inhibition of sEH in human HepG2 cells assessed as NF-kappaB mRNA expression at 10 uM after 8 to 16 hrs by SYBR green based qRT-PCR analysis relative to DMSO control";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4066332";"";"0";"394.92";"0";"3.94";"57";"CC(C)(C)c1ccc(C(=O)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL4019486";"Inhibition of sEH in primary human monocytes-derived macrophages assessed as reduction in LPS-stimulated IL-12p70 release at 0.01 uM after 16 hrs by cytometric bead array method";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL3617994";"";"0";"418.40";"1";"-0.89";"3";"O=C1c2c(O)cccc2[C@@H]([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cc(CO)cc(O)c21";"IC50";"'='";"41100.0";"nM";"4.39";"";"";"UO_0000065";"10.48";"0.20";"5.28";"2.61";"False";"CHEMBL3620669";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL4081891";"";"0";"310.40";"0";"3.01";"37";"CC(C)(C)c1ccc(C(=O)NCc2ccc(C(N)=O)cc2)cc1";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"19.07";"0.35";"2.91";"8.20";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL143549";"";"0";"298.34";"0";"2.38";"19";"CN(C)c1ccc(C(=O)NCc2ccc(C(=O)O)cc2)cc1";"Inhibition";"'='";"19.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL1873898";"";"0";"220.34";"0";"2.31";"3";"CC1CN=C(NCCc2ccccc2)S1";"IC50";"'='";"6300.0";"nM";"5.20";"";"";"UO_0000065";"23.60";"0.47";"2.89";"21.32";"False";"CHEMBL3240515";"Inhibition of human full-length C-terminal His6-tagged sEH expressed in Escherichia coli BL21(DE3) cells using PHOME as substrate incubated with enzyme for 15 mins prior to substrate challenge for 50 mins by fluorescence plate reader analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232970";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3236506";"";"0";"356.37";"0";"-0.47";"4";"COC/C=C/c1ccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(OC)c1";"Inhibition";"'<'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL251254";"HYPEROSIDE";"0";"464.38";"2";"-0.54";"16";"O=c1c(O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12";"Inhibition";"'>'";"40.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3243098";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis at 25 uM after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263294";"";"0";"498.76";"1";"5.57";"2b";"CC(NC(=O)NCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"T1/2";"'='";"0.1333";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3270576";"Displacement of ACPU from recombinant human soluble epoxide hydrolase assessed as compound residence time after 1.5 hrs by FRET assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263289";"";"0";"498.76";"1";"5.58";"1c";"O=C(NCCCCCCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"18.84";"0.36";"3.82";"11.42";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263294";"";"0";"498.76";"1";"5.57";"2b";"CC(NC(=O)NCCCCNC(=O)NC(C)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"Ki";"'='";"2.7";"nM";"8.57";"";"";"UO_0000065";"17.18";"0.33";"3.00";"10.42";"False";"CHEMBL3270577";"Displacement of ACPU from recombinant human soluble epoxide hydrolase after 1.5 hrs by FRET assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3103787";"";"0";"399.49";"0";"3.19";"25";"CON(C)C(=O)C(=O)Nc1ccc(NC(=O)CC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"35.0";"nM";"7.46";"";"";"UO_0000065";"18.66";"0.35";"4.27";"8.50";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3104435";"";"0";"498.89";"0";"4.17";"32";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3cc(Cl)ccn3)CC2)C1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"18.48";"0.37";"5.05";"10.98";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3099591";"";"0";"244.17";"0";"2.82";"m";"COc1ccc2c(=O)cc(C(F)(F)F)oc2c1";"Activity";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3102106";"Binding affinity to soluble epoxide hydrolase (unknown origin) at 400 uM by STD-NMR assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL3809736";"";"0";"282.39";"0";"3.68";"8b(S)";"C[C@H](NC(=O)NCCCc1ccccc1)c1ccccc1";"IC50";"'='";"44.0";"nM";"7.36";"";"";"UO_0000065";"26.05";"0.48";"3.68";"17.89";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3809673";"";"0";"282.39";"0";"3.68";"8b(R)";"C[C@@H](NC(=O)NCCCc1ccccc1)c1ccccc1";"IC50";"'='";"1730.0";"nM";"5.76";"";"";"UO_0000065";"20.40";"0.37";"2.08";"14.01";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL2392739";"";"0";"316.41";"0";"3.28";"51";"O=C(Nc1nnc(C2CCC2)o1)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"382.0";"nM";"6.42";"";"";"UO_0000065";"20.28";"0.38";"3.14";"8.02";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392735";"";"0";"275.35";"0";"2.93";"47";"Cc1cc(NC(=O)NC2C3CC4CC(C3)CC2C4)no1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"30.15";"0.57";"5.37";"12.36";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392733";"";"0";"261.33";"0";"2.62";"45";"O=C(Nc1ncco1)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"46.0";"nM";"7.34";"";"";"UO_0000065";"28.08";"0.53";"4.72";"10.93";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392750";"";"0";"272.35";"0";"2.57";"17";"O=C(Nc1ncccn1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"24010.0";"nM";"4.62";"";"";"UO_0000065";"16.96";"0.32";"2.05";"6.90";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392711";"";"0";"492.55";"0";"2.22";"4";"CNc1nc(N2CCC(C(=O)NCc3ccccc3C(F)(F)F)CC2)nc(N2CCN(C)CC2)n1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2393705";"Inhibition of human soluble epoxide hydrolase overexpressed in HEK293F cells using EET as substrate assessed as formation of DHET incubated for 30 mins prior to substrate addition measured after 60 mins by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HEK293F";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3322828";"";"0";"342.48";"0";"3.47";"BDBM179753";"CCCCCNC(=O)NCCCC/C=C\CCCCOCC(=O)O";"IC50";"'='";"237.0";"nM";"6.62";"";"326377";"UO_0000065";"19.34";"0.38";"3.16";"7.56";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL2425009";"";"0";"390.51";"0";"2.49";"9a";"CCNC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(C)(=O)=O)cc2)CC1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL3322808";"";"0";"438.63";"0";"4.94";"BDBM50057474";"CCCCCNC(=O)NCCCC/C=C\CCCCCS(=O)(=O)c1ccccc1O";"IC50";"'='";"11.0";"nM";"7.96";"";"326387";"UO_0000065";"18.14";"0.36";"3.02";"8.33";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3913832";"";"0";"378.26";"0";"2.96";"BDBM181775";"O=C(NCc1ccc(Cl)cc1Cl)N1CC2(CCN2c2ncccn2)C1";"IC50";"'='";"125.0";"nM";"6.90";"";"328782";"UO_0000065";"18.25";"0.38";"3.94";"11.25";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL409450";"6BIO";"0";"356.18";"0";"3.42";"15, 6BIO";"O=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2/C1=N\O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3270681";"Inhibition of human recombinant soluble epoxide hydrolase assessed as conversion of 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid to fluorescent 6-methoxy-naphthaldehyde at 10 uM after 10 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259773";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL4104050";"";"0";"329.37";"0";"3.75";"27";"CC(C)(C)c1ccc(C(=O)NCc2ccc(C(=O)O)c(F)c2)cc1";"IC50";"'='";"20300.0";"nM";"4.69";"";"";"UO_0000065";"14.25";"0.27";"0.94";"7.07";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4060350";"";"0";"329.37";"0";"3.75";"30";"CC(C)(C)c1ccc(C(=O)NCc2ccc(C(=O)O)cc2F)cc1";"IC50";"'='";"1430.0";"nM";"5.84";"";"";"UO_0000065";"17.74";"0.33";"2.09";"8.80";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL595";"PIOGLITAZONE";"4";"356.45";"0";"3.16";"Pioglitazone";"CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3617997";"";"0";"534.51";"3";"-1.40";"6, aloinoside C";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@H]([C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"IC50";"'='";"13800.0";"nM";"4.86";"";"";"UO_0000065";"9.09";"0.17";"6.26";"2.35";"False";"CHEMBL3620669";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL2436564";"";"0";"483.44";"1";"5.02";"12";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3c(F)cccc3F)CC2)C1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"19.44";"0.38";"4.38";"15.19";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3634699";"";"0";"596.54";"3";"-2.03";"10";"COc1cc(O[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)c2c(O)c3c(=O)cc(C)oc3cc2c1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3677988";"";"0";"369.85";"0";"4.72";"BDBM158499";"N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)cc3)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"301058";"UO_0000065";"25.15";"0.49";"4.58";"12.54";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3402239";"";"0";"245.08";"0";"1.61";"Fragment 8";"O=C(O)Cn1cc(Br)c(C2CC2)n1";"IC50";"'='";"91000.0";"nM";"4.04";"";"";"UO_0000065";"16.49";"0.42";"2.43";"7.33";"False";"CHEMBL3406221";"Inhibition of C-terminal His6-tagged full-length human soluble epoxide hydrolase expressed in Escherichia coli BL21(DE3) cells pre-incubated for 15 mins before addition of PHOME substrate and measured 50 mins after substrate addition by microplate reader based fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400124";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3325465";"";"0";"337.51";"0";"3.29";"17";"CCC(C)C(=O)N1CCC(NC(=O)N[C@H]2CC[C@H](CC)CC2)CC1";"T1/2";"'='";"0.55";"hr";"";"";"";"UO_0000032";"";"";"";"";"False";"CHEMBL3361516";"Inhibition of human recombinant soluble epoxide hydrolase assessed as half-life of enzyme-inhibitor complex by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327072";"";"0";"359.51";"0";"4.14";"12";"CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(C)(C)C)cc2)CC1";"Ki";"'='";"2.44";"nM";"8.61";"";"";"UO_0000065";"23.96";"0.45";"4.47";"14.02";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3327070";"";"0";"411.35";"0";"4.16";"10";"O=C(Nc1ccc(C(F)(F)F)cc1)NC1CCN(C(=O)CCC(F)(F)F)CC1";"Ki";"'='";"1.2";"nM";"8.92";"";"";"UO_0000065";"21.69";"0.44";"4.76";"14.52";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322804";"";"0";"437.65";"0";"4.74";"BDBM50057450";"CCCCCNC(=O)NCCCC/C=C\CCCCCNS(=O)(=O)c1ccccc1";"IC50";"'='";"32.0";"nM";"7.50";"";"423466";"UO_0000065";"17.13";"0.34";"2.75";"8.59";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322809";"";"0";"382.58";"0";"4.07";"BDBM50057480";"CCCCCNC(=O)NCCCC/C=C\CCCCCSc1nnn[nH]1";"IC50";"'='";"22.0";"nM";"7.66";"";"423469";"UO_0000065";"20.02";"0.40";"3.59";"8.01";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322797";"";"0";"472.67";"0";"4.11";"2";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)OCCOCCOCCO";"IC50";"'='";"255.0";"nM";"6.59";"";"";"UO_0000065";"13.95";"0.27";"2.48";"6.21";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322804";"";"0";"437.65";"0";"4.74";"9";"CCCCCNC(=O)NCCCC/C=C\CCCCCNS(=O)(=O)c1ccccc1";"IC50";"'='";"32.0";"nM";"7.50";"";"";"UO_0000065";"17.13";"0.34";"2.75";"8.59";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322808";"";"0";"438.63";"0";"4.94";"13";"CCCCCNC(=O)NCCCC/C=C\CCCCCS(=O)(=O)c1ccccc1O";"IC50";"'='";"11.0";"nM";"7.96";"";"";"UO_0000065";"18.14";"0.36";"3.02";"8.33";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322811";"";"0";"397.59";"0";"3.69";"16";"CCCCCNC(=O)NCCCC/C=C\CCCCC[S+]([O-])c1ncn[nH]1";"IC50";"'='";"96.0";"nM";"7.02";"";"";"UO_0000065";"17.65";"0.35";"3.33";"7.03";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322819";"";"0";"441.68";"1";"5.77";"24";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCC1=NOS(=O)N1)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3322827";"";"0";"420.54";"0";"2.84";"32";"CCCCNC(=O)C(=O)NCCCCCOc1cccc2sc(NC(C)=O)nc12";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3263295";"";"0";"554.86";"2";"6.85";"2c";"CCC(CNC(=O)NCCCCNC(=O)NCC(CC)C12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2.3";"nM";"8.64";"";"";"UO_0000065";"15.57";"0.29";"1.79";"10.50";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3322828";"";"0";"342.48";"0";"3.47";"BDBM179753";"CCCCCNC(=O)NCCCC/C=C\CCCCOCC(=O)O";"IC50";"'='";"237.0";"nM";"6.62";"";"423458";"UO_0000065";"19.34";"0.38";"3.16";"7.56";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4128609";"";"0";"372.62";"0";"4.88";"4e";"S=C(NCCC12CC3CC(CC(C3)C1)C2)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"259.0";"nM";"6.59";"";"";"UO_0000065";"17.68";"0.35";"1.71";"27.38";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL2436572";"";"0";"465.45";"0";"4.88";"20";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3ccccc3F)CC2)C1";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"19.67";"0.38";"4.27";"14.79";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3327071";"";"0";"345.49";"0";"3.97";"11";"CCC(C)C(=O)N1CCC(NC(=O)Nc2ccc(C(C)C)cc2)CC1";"Ki";"'='";"1.17";"nM";"8.93";"";"";"UO_0000065";"25.85";"0.49";"4.96";"14.54";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL3818875";"";"0";"447.47";"0";"3.40";"GSK2256294";"CNc1nc(C)nc(N[C@H]2CCC[C@@H](C(=O)NCc3ccc(C#N)cc3C(F)(F)F)C2)n1";"IC50";"'='";"0.027";"nM";"10.57";"";"";"UO_0000065";"23.62";"0.45";"7.17";"9.14";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4105571";"";"0";"339.44";"0";"4.26";"3";"COc1ccc(C(=O)NCc2ccccc2C)cc1OC1CCCC1";"IC50";"'='";"180.0";"nM";"6.75";"";"";"UO_0000065";"19.87";"0.37";"2.48";"14.18";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL3114598";"";"0";"366.46";"0";"3.80";"20";"COc1ccccc1OC1CCN(C(=O)N[C@H]2C[C@@H]2c2ccccc2)CC1";"IC50";"'='";"11.3";"nM";"7.95";"";"";"UO_0000065";"21.69";"0.40";"4.15";"15.64";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL1076184";"CIMIRACEMATE A";"0";"358.35";"0";"2.18";"2";"COc1ccc(/C=C/C(=O)OCC(=O)Cc2ccc(O)c(O)c2)cc1O";"IC50";"'='";"1100.0";"nM";"5.96";"";"";"UO_0000065";"16.63";"0.31";"3.78";"5.26";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL2180627";"";"0";"461.44";"0";"4.93";"5i";"CCOC(=O)c1cccn1Cc1ccc(CNC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1";"IC50";"'='";"611.0";"nM";"6.21";"";"";"UO_0000065";"13.47";"0.26";"1.28";"7.62";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL3322807";"";"0";"406.64";"1";"6.26";"BDBM50057466";"CCCCCNC(=O)NCCCC/C=C\CCCCCSc1ccccc1O";"IC50";"'='";"6.0";"nM";"8.22";"";"423467";"UO_0000065";"20.22";"0.40";"1.96";"13.40";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322808";"";"0";"438.63";"0";"4.94";"BDBM50057474";"CCCCCNC(=O)NCCCC/C=C\CCCCCS(=O)(=O)c1ccccc1O";"IC50";"'='";"11.0";"nM";"7.96";"";"423468";"UO_0000065";"18.14";"0.36";"3.02";"8.33";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322818";"";"0";"400.59";"0";"4.05";"BDBM50057625";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC1=NOS(=O)N1";"IC50";"'='";"10.0";"nM";"8.00";"";"423479";"UO_0000065";"19.97";"0.40";"3.95";"8.71";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4060303";"";"0";"199.25";"0";"2.99";"4";"CC(C)=C/C=C1/C(=O)Nc2ccccc21";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL32969";"";"0";"208.21";"0";"1.59";"7";"COC(=O)/C=C/c1ccc(O)c(OC)c1";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL66796";"";"0";"327.81";"0";"3.38";"15";"CCCCCOC(=O)NCCNC(=O)Nc1cccc(Cl)c1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL677485";"Tested for 50 % inhibitory concentration against human soluble epoxide hydrolase (sEH)";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1149149";"1";"Scientific Literature";"J. Med. Chem.";"2004";"None"
"CHEMBL2180619";"";"0";"383.49";"0";"3.85";"5a";"CCOC(=O)c1cccn1Cc1ccccc1CNC(=O)NC1CCCCC1";"IC50";"'='";"39.0";"nM";"7.41";"";"";"UO_0000065";"19.32";"0.36";"3.56";"10.24";"False";"CHEMBL2182823";"Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2177035";"1";"Scientific Literature";"J. Med. Chem.";"2012";"None"
"CHEMBL2424983";"";"0";"452.58";"0";"3.67";"9g";"Cc1cc(C2CCN(C(=O)NCc3ccccc3)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"Inhibition";"'='";"94.22";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2425003";"";"0";"419.55";"0";"2.52";"8d";"CCCCNC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(N)(=O)=O)cc2)CC1";"Inhibition";"'='";"81.95";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2031790";"";"0";"404.56";"0";"2.18";"133";"O=C(NC1CCCC(C(=O)NN2CCOCC2)C1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"25.8";"nM";"7.59";"";"";"UO_0000065";"18.76";"0.36";"5.41";"9.18";"False";"CHEMBL2032586";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2029208";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2012";"None"
"CHEMBL2424988";"";"0";"466.61";"0";"3.72";"9l";"Cc1cc(C2CCN(C(=O)NCCc3ccccc3)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2348191";"";"0";"300.23";"0";"2.25";"4e";"O=C(Oc1cccc2oc(=O)[nH]c12)c1ccccc1[N+](=O)[O-]";"Inhibition";"'='";"29.18";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"68.0";"nM";"7.17";"";"";"UO_0000065";"18.26";"0.35";"1.93";"9.14";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL566315";"OBETICHOLIC ACID";"4";"420.63";"1";"5.11";"1a; OCA; 6alpha-ethyl-CDCA";"CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4019506";"Inhibition of sEH in primary human monocytes-derived macrophages assessed as reduction in LPS-stimulated IL-12p70 release at 1 uM after 16 hrs by cytometric bead array method";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL3401639";"";"0";"493.60";"0";"4.23";"19";"O=C(N[C@H]1[C@H](c2ccccc2)[C@@H]1c1ccccc1)N1CCC[C@@H](NS(=O)(=O)c2ccc(F)cc2)C1";"IC50";"'='";"0.7";"nM";"9.15";"";"";"UO_0000065";"18.55";"0.36";"4.92";"11.66";"False";"CHEMBL3406976";"Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400076";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3933063";"";"0";"467.51";"0";"3.50";"BDBM181781";"O=C(NCCCc1ccccc1)N1CC2(CCN2S(=O)(=O)c2ccccc2C(F)(F)F)C1";"IC50";"'='";"476.0";"nM";"6.32";"";"328788";"UO_0000065";"13.52";"0.27";"2.82";"9.07";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4068899";"";"0";"331.37";"0";"3.98";"13";"O=C(O)c1ccc(CNC(=O)c2ccc(-c3ccccc3)cc2)cc1";"IC50";"'='";"8100.0";"nM";"5.09";"";"";"UO_0000065";"15.37";"0.28";"1.11";"7.67";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4104471";"";"0";"261.32";"0";"2.58";"4a";"O=C(O)c1ccc(CNC(=O)C2CCCCC2)cc1";"Inhibition";"'='";"37.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4084092";"";"0";"315.33";"0";"2.33";"15";"COc1ccc(C(=O)NCc2ccc(C(=O)O)cc2)cc1OC";"Inhibition";"'='";"26.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4079796";"";"0";"325.41";"0";"3.92";"26";"Cc1cc(CNC(=O)c2ccc(C(C)(C)C)cc2)ccc1C(=O)O";"Inhibition";"'='";"53.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL438867";"";"0";"402.54";"0";"4.21";"30";"CCOCCOCCOc1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"22.26";"0.42";"4.75";"13.02";"False";"CHEMBL992693";"Inhibition of human soluble epoxide hydrolase by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1153910";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL584050";"";"0";"393.37";"1";"6.74";"7dd";"FC(F)(F)c1ccc(Nc2noc3cc(-c4ccc5[nH]ccc5c4)ccc23)cc1";"IC50";"'='";"70.0";"nM";"7.16";"";"";"UO_0000065";"18.19";"0.34";"0.41";"13.29";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL578548";"";"0";"422.33";"1";"7.28";"7gg";"FC(F)(F)c1ccc(Nc2noc3c(-c4ccccc4C(F)(F)F)cccc23)cc1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"19.88";"0.38";"1.12";"22.07";"False";"CHEMBL1044409";"Inhibition of human sEH";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1156003";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2009";"None"
"CHEMBL4096300";"";"0";"297.40";"0";"3.41";"33";"CC(C)(C)c1ccc(C(=O)NCc2ccc(CO)cc2)cc1";"IC50";"'='";"2050.0";"nM";"5.69";"";"";"UO_0000065";"19.13";"0.35";"2.28";"11.53";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL3764891";"";"0";"345.83";"0";"3.92";"11c";"CCC(Cc1ccc(C(=O)NCc2ccc(Cl)cc2)cc1)C(=O)O";"IC50";"'='";"1500.0";"nM";"5.82";"";"";"UO_0000065";"16.84";"0.33";"1.90";"8.77";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3322815";"";"0";"378.57";"0";"4.30";"20";"CCCCCNC(=O)NCCCC/C=C\CCCCCCCc1nnn[nH]1";"IC50";"'='";"32.0";"nM";"7.50";"";"";"UO_0000065";"19.80";"0.38";"3.19";"7.84";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL4217337";"";"0";"634.81";"2";"2.01";"18";"C[C@@H]1C[C@H]2O[C@@]3(O[C@H]2C(C)(C)O)[C@H](O)[C@@]2(C)C4=CC[C@H]5C(C)(C)[C@@H](O[C@@H]6OC[C@@H](O)[C@H](O)[C@H]6O)CC[C@@]56C[C@@]46C[C@@H](O)[C@]2(C)[C@@H]13";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4191393";"Non-competitive inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4212729";"";"0";"636.82";"2";"2.09";"7";"C[C@@H]1[C@H]2OC(C)(C)[C@@H](O)[C@@]2(O)O[C@H]2[C@H](O)[C@@]3(C)[C@@H]4CC[C@H]5C(C)(C)[C@@H](O[C@@H]6OC[C@@H](O)[C@H](O)[C@H]6O)CC[C@@]56C[C@@]46CC[C@]3(C)[C@@H]12";"Inhibition";"'='";"70.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4191389";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate at 100 uM measured for 1 hr by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4216368";"";"0";"410.39";"0";"4.80";"18";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(O)cc2)CC1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"21.20";"0.41";"3.90";"10.90";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4078618";"";"0";"311.38";"0";"3.61";"22";"CC(C)(C)c1ccc(C(=O)NCc2cccc(C(=O)O)c2)cc1";"Inhibition";"'='";"26.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4095377";"";"0";"366.34";"0";"3.60";"6";"COc1ccc(CNC(=O)c2cccc(NC(C)=O)c2)c(C(F)(F)F)c1";"IC50";"'='";"2.9";"nM";"8.54";"";"";"UO_0000065";"23.31";"0.45";"4.94";"12.66";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4099452";"";"0";"393.41";"0";"4.97";"19";"COc1ccc(CNC(=O)c2cccc(OC3CCCC3)c2)c(C(F)(F)F)c1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"23.89";"0.46";"4.43";"19.76";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL1668932";"";"0";"329.32";"0";"2.84";"1";"CC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"Ki";"'='";"14.6";"nM";"7.84";"";"";"UO_0000065";"23.79";"0.47";"5.00";"12.75";"False";"CHEMBL3361515";"Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3351722";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL1258335";"";"0";"309.80";"0";"2.86";"BDBM50327822";"CCC(=O)N1CCC(NC(=O)Nc2ccc(Cl)cc2)CC1";"IC50";"'='";"10.0";"nM";"8.00";"";"377028";"UO_0000065";"25.82";"0.52";"5.14";"13.02";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1258336";"";"0";"354.25";"0";"2.97";"BDBM50327808";"CCC(=O)N1CCC(NC(=O)Nc2ccc(Br)cc2)CC1";"IC50";"'='";"3.6";"nM";"8.44";"";"377029";"UO_0000065";"23.84";"0.55";"5.47";"13.74";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL2436575";"";"0";"498.51";"1";"5.29";"23";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)c3cccc4ncccc34)CC2)C1";"IC50";"'='";"0.2";"nM";"9.70";"";"";"UO_0000065";"19.46";"0.37";"4.41";"12.97";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436592";"";"0";"427.47";"0";"4.62";"40";"CCCCC(=O)N1CCC2(CC1)CCN(C(=O)Nc1ccc(OC(F)(F)F)cc1)C2";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"21.28";"0.41";"4.48";"14.70";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2436583";"";"0";"455.48";"0";"3.86";"31";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCC2(CCN(C(=O)C3CCOCC3)CC2)C1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"18.71";"0.36";"4.66";"11.99";"False";"CHEMBL2437612";"Inhibition of human recombinant sEH using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 20 to 45 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2434828";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL4063944";"";"0";"375.29";"0";"4.25";"14";"COc1ccc(CNC(=O)c2ccc(OC(F)F)cc2)c(C(F)(F)F)c1";"IC50";"'='";"1.5";"nM";"8.82";"";"";"UO_0000065";"23.51";"0.46";"4.57";"18.55";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL3764450";"";"0";"421.46";"1";"5.16";"18b";"CCCC(Cc1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1)C(=O)OCC";"IC50";"'='";"170.0";"nM";"6.77";"";"";"UO_0000065";"16.06";"0.31";"1.61";"12.22";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764453";"";"0";"427.42";"1";"5.05";"19c";"O=C(NCc1ccccc1C(F)(F)F)c1ccc(CC(C(=O)O)c2ccccc2)cc1";"IC50";"'='";"2500.0";"nM";"5.60";"";"";"UO_0000065";"13.11";"0.25";"0.55";"8.44";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764398";"";"0";"409.40";"0";"4.30";"14c";"CCC(Cc1ccc(C(=O)NCc2ccc(OC)cc2C(F)(F)F)cc1)C(=O)O";"IC50";"'='";"330.0";"nM";"6.48";"";"";"UO_0000065";"15.83";"0.31";"2.18";"8.57";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3558235";"";"0";"455.60";"0";"3.59";"BDBM179755";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)O";"IC50";"'='";"392.0";"nM";"6.41";"";"326380";"UO_0000065";"14.06";"0.27";"2.82";"4.42";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3927470";"";"0";"414.57";"0";"2.60";"BDBM179761";"CCCCNC(=O)C(=O)NCCCC/C=C\CCCCCCC1=NOS(=O)N1";"IC50";"'>'";"500.0";"nM";"";"";"326400";"UO_0000065";"";"";"";"";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3628771";"";"0";"598.57";"2";"7.65";"18";"CC(C)(C)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)P(=O)(OCC(F)(F)F)OCC(F)(F)F";"IC50";"'='";"30.0";"nM";"7.52";"";"";"UO_0000065";"12.57";"0.26";"-0.13";"9.81";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628781";"";"0";"629.78";"2";"8.87";"28";"CC(C)(C)C(Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1)P(=O)(OCc1ccccc1)OCc1ccccc1";"IC50";"'='";"2.6";"nM";"8.59";"";"";"UO_0000065";"13.63";"0.26";"-0.28";"9.68";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628413";"";"0";"568.65";"2";"6.68";"7";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)c1ccc(C(=O)OC)cc1";"IC50";"'='";"230.0";"nM";"6.64";"";"";"UO_0000065";"11.67";"0.23";"-0.04";"6.45";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3222131";"";"0";"503.71";"1";"3.97";"8d";"CS(=O)(=O)N1CCN(CCCCOc2cccc(NC(=O)CC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"18.47";"0.36";"5.33";"11.78";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3633680";"";"0";"409.53";"0";"4.90";"4b";"COc1ccc(-c2cc(CNC(=O)NC34CC5CC(C)(CC(C)(C5)C3)C4)no2)cc1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"19.10";"0.36";"2.92";"10.24";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL2348392";"";"0";"325.73";"0";"2.54";"5c";"O=c1[nH]c2c(OS(=O)(=O)c3cccc(Cl)c3)cccc2o1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348401";"";"0";"308.29";"0";"1.55";"3a";"CC(C)(C)OC(=O)NCC(=O)Oc1cccc2oc(=O)[nH]c12";"IC50";"'='";"17200.0";"nM";"4.76";"";"";"UO_0000065";"15.45";"0.30";"3.21";"4.31";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2397136";"";"0";"420.51";"0";"4.32";"21";"CNC(=O)c1cc(Oc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"22.12";"0.41";"4.98";"10.07";"True";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2397139";"";"0";"425.57";"0";"4.00";"14";"CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)NC34CC5CC(CC(C5)C3)C4)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"21.86";"0.41";"5.30";"11.71";"True";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1539296";"";"0";"284.40";"0";"3.45";"27";"O=C(NCc1ccccc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"16.0";"nM";"7.80";"";"";"UO_0000065";"27.41";"0.51";"4.35";"18.95";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL184238";"URB-597";"1";"338.41";"0";"3.87";"URB597";"NC(=O)c1cccc(-c2cccc(OC(=O)NC3CCCCC3)c2)c1";"TDI";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4187627";"Time dependent inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction pre-incubated for 10 to 70 mins before CMNPC substrate addition by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1803092";"";"0";"354.49";"0";"3.17";"29";"CNC(=O)C(=O)NC/C=C\CCCCCCCCCCCCC(=O)O";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL1804588";"Inhibition of soluble epoxide hydrolase at 5 uM";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1799995";"1";"Scientific Literature";"J. Med. Chem.";"2011";"None"
"CHEMBL4280282";"";"0";"596.11";"2";"6.04";"5";"COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12";"IC50";"'='";"7000.0";"nM";"5.16";"";"";"UO_0000065";"8.65";"0.17";"-0.89";"4.45";"False";"CHEMBL4256761";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by spectrofluorimetry";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL1933668";"";"0";"439.43";"0";"4.29";"14-51";"O=C(NC1CCCCCC1)C1CCN(S(=O)(=O)c2cc(Cl)sc2Cl)CC1";"IC50";"'='";"21.0";"nM";"7.68";"";"";"UO_0000065";"17.47";"0.40";"3.39";"11.55";"False";"CHEMBL1936453";"Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1932975";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL2313184";"";"0";"446.53";"0";"3.08";"7-46";"COc1cc2c(cc1NC(=O)C1CCN(S(=O)(=O)c3ccc(C)cc3C)CC1)OCO2";"IC50";"'='";"30000.0";"nM";"4.52";"";"";"UO_0000065";"10.13";"0.20";"1.44";"4.80";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313193";"";"0";"388.49";"0";"3.05";"7-10";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(O)cc3)CC2)c(C)c1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"24.19";"0.48";"6.35";"10.84";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2313189";"";"0";"430.61";"0";"3.79";"7-6";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)NC34CC5CC(CC(C5)C3)C4)CC2)c(C)c1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"20.37";"0.40";"4.98";"13.19";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"107000.0";"nM";"";"Outside typical range";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764333";"";"0";"347.30";"0";"2.82";"27";"O=C(NCc1ccccc1C(F)(F)F)c1ccc(-c2nnn[nH]2)cc1";"IC50";"'='";"5000.0";"nM";"5.30";"";"";"UO_0000065";"15.26";"0.29";"2.48";"6.34";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764393";"";"0";"405.42";"0";"4.99";"1a";"CCOC(=O)/C(=C/c1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1)CC";"IC50";"'='";"63.0";"nM";"7.20";"";"";"UO_0000065";"17.76";"0.34";"2.21";"13.00";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3765141";"";"0";"379.38";"0";"4.29";"1c";"CCC(Cc1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1)C(=O)O";"IC50";"'='";"1600.0";"nM";"5.80";"";"";"UO_0000065";"15.28";"0.29";"1.51";"8.73";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3763549";"";"0";"373.88";"0";"4.40";"4b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccccc2Cl)cc1";"IC50";"'='";"3800.0";"nM";"5.42";"";"";"UO_0000065";"14.50";"0.28";"1.02";"9.78";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3401634";"";"0";"484.60";"1";"5.21";"14";"O=C(O)CCc1ccc(OC2CCN(C(=O)N[C@H]3[C@H](c4ccccc4)[C@@H]3c3ccccc3)CC2)cc1";"IC50";"'='";"2.3";"nM";"8.64";"";"";"UO_0000065";"17.83";"0.33";"3.43";"10.95";"False";"CHEMBL3406976";"Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400076";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL2397146";"";"0";"470.88";"0";"4.63";"9";"CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)cn1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"19.75";"0.40";"4.67";"10.07";"True";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2425011";"";"0";"404.54";"0";"2.88";"9c";"Cc1cc(C2CCN(C(=O)NC(C)C)CC2)n(-c2ccc(S(C)(=O)=O)cc2)n1";"IC50";"'='";"13607.0";"nM";"4.87";"";"";"UO_0000065";"12.03";"0.24";"1.99";"5.77";"False";"CHEMBL2427204";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2425007";"";"0";"453.57";"0";"3.55";"8h";"Cc1ccc(NC(=O)N2CCC(c3cc(C)nn3-c3ccc(S(N)(=O)=O)cc3)CC2)cc1";"IC50";"'='";"224.0";"nM";"6.65";"";"";"UO_0000065";"14.66";"0.28";"3.10";"6.03";"False";"CHEMBL2427204";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2392721";"";"0";"291.42";"0";"3.54";"33";"Cc1csc(NC(=O)NC23CC4CC(CC(C4)C2)C3)n1";"IC50";"'='";"485.0";"nM";"6.31";"";"";"UO_0000065";"21.67";"0.43";"2.77";"11.69";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392762";"";"0";"309.80";"0";"3.73";"29";"Cc1noc(NC(=O)NC23CC4CC(CC(C4)C2)C3)c1Cl";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"30.02";"0.60";"5.57";"13.85";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392707";"";"0";"354.46";"0";"2.06";"19";"CNc1nc(C)nc(N2CCC(C(=O)NCc3ccccc3C)CC2)n1";"IC50";"'='";"200.0";"nM";"6.70";"";"";"UO_0000065";"18.90";"0.35";"4.64";"8.07";"False";"CHEMBL2393704";"Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior to substrate addition measured with in 30 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390902";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1257877";"";"0";"317.43";"0";"3.33";"BDBM50327857";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(C)C)cc2)CC1";"IC50";"'='";"2.8";"nM";"8.55";"";"377017";"UO_0000065";"26.94";"0.51";"5.22";"13.92";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1258105";"";"0";"360.46";"0";"2.05";"BDBM50327836";"CCC(=O)N1CCC(NC(=O)Nc2ccc(N3CCOCC3)cc2)CC1";"IC50";"'='";"2000.0";"nM";"5.70";"";"377022";"UO_0000065";"15.81";"0.30";"3.65";"7.71";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1258107";"";"0";"333.39";"0";"2.00";"BDBM50327831";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(=O)OC)cc2)CC1";"IC50";"'='";"140.0";"nM";"6.85";"";"377024";"UO_0000065";"20.56";"0.39";"4.85";"7.81";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL2070327";"";"0";"364.53";"0";"4.16";"5";"CCCCC(C)OC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"23.04";"0.44";"4.24";"12.45";"False";"CHEMBL2071799";"Inhibition of human soluble epoxide hydrolase pre-incubated for 5 mins at 30 degC before CMNPC fluorescent substrate addition by fluorimetric assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2069299";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL2348406";"";"0";"437.45";"0";"3.64";"3f";"CC(C)(C)OC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)Oc1cccc2oc(=O)[nH]c12";"Inhibition";"'='";"79.58";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348400";"";"0";"313.26";"0";"-1.70";"6a";"O=c1[nH]c2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cccc2o1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348399";"";"0";"305.31";"0";"2.20";"5j";"Cc1ccc(S(=O)(=O)Oc2cccc3oc(=O)[nH]c23)cc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348393";"";"0";"325.73";"0";"2.54";"5d";"O=c1[nH]c2c(OS(=O)(=O)c3ccc(Cl)cc3)cccc2o1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348190";"";"0";"289.67";"0";"2.99";"4d";"O=C(Oc1cccc2oc(=O)[nH]c12)c1ccc(Cl)cc1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL249447";"";"0";"516.46";"3";"1.03";"3";"O=C(/C=C/c1ccc(O)c(O)c1)O[C@@H]1C[C@](O)(C(=O)O)C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@H]1O";"Inhibition";"'='";"81.3";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4010815";"Inhibition of sEH (unknown origin) at 100 uM using PHOME as substrate after 40 mins by fluorescence photometric method relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL2158540";"";"0";"374.45";"0";"3.04";"15";"O=C(NCCCNc1ncc(-c2ccncc2)c(C2CC2)n1)c1ccccn1";"IC50";"'='";"25000.0";"nM";"4.60";"";"";"UO_0000065";"12.29";"0.22";"1.56";"4.97";"False";"CHEMBL2162306";"Inhibition of sEH using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to substrate addition measured every min for 15 mins by fluorimetric analysis";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2157944";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2012";"None"
"CHEMBL214943";"";"0";"333.48";"0";"2.66";"BDBM100363";"CCC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1";"IC50";"'='";"2.8";"nM";"8.55";"";"377005";"UO_0000065";"25.65";"0.49";"5.89";"13.92";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257758";"";"0";"443.45";"0";"3.56";"BDBM50327849";"O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(S(=O)(=O)c2ccccc2)CC1";"IC50";"'='";"1.8";"nM";"8.74";"";"377054";"UO_0000065";"19.72";"0.40";"5.18";"9.97";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257879";"";"0";"367.45";"0";"4.00";"BDBM50327843";"CCC(=O)N1CCC(NC(=O)Nc2ccc(Oc3ccccc3)cc2)CC1";"IC50";"'='";"3.5";"nM";"8.46";"";"377019";"UO_0000065";"23.01";"0.43";"4.46";"11.97";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL2348389";"";"0";"269.26";"0";"2.65";"4j";"Cc1ccc(C(=O)Oc2cccc3oc(=O)[nH]c23)cc1";"Inhibition";"'='";"98.31";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348190";"";"0";"289.67";"0";"2.99";"4d";"O=C(Oc1cccc2oc(=O)[nH]c12)c1ccc(Cl)cc1";"Inhibition";"'='";"27.8";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2353533";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde at 10 ug/ml after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348187";"";"0";"313.26";"0";"-1.70";"6b";"O=c1[nH]c2c(O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)cccc2o1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348398";"";"0";"305.31";"0";"2.20";"5i";"Cc1cccc(S(=O)(=O)Oc2cccc3oc(=O)[nH]c23)c1";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2348406";"";"0";"437.45";"0";"3.64";"3f";"CC(C)(C)OC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)Oc1cccc2oc(=O)[nH]c12";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL2353534";"Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2346634";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2336307";"";"0";"616.08";"2";"8.02";"8e";"COc1cc(-c2nc3ccc(Cl)cn3c2NC2CCCCC2)ccc1OCCCNC(=O)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"30.0";"nM";"7.52";"";"";"UO_0000065";"12.21";"0.24";"-0.50";"8.46";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2336299";"";"0";"565.64";"2";"7.66";"8q";"Cc1ccc2nc(-c3ccc(OCCCNC(=O)Nc4ccc(C(F)(F)F)cc4)cc3)c(NC3CCCCC3)n2c1";"IC50";"'='";"62.0";"nM";"7.21";"";"";"UO_0000065";"12.74";"0.24";"-0.45";"9.04";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2397149";"";"0";"446.39";"0";"4.78";"BDBM50436431";"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"301054";"UO_0000065";"20.84";"0.40";"4.52";"9.16";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3677987";"";"0";"403.40";"1";"5.09";"BDBM158498";"N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(C(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"301057";"UO_0000065";"23.06";"0.44";"4.21";"12.54";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4127060";"";"0";"496.76";"1";"8.43";"3j";"S=C(Nc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)Nc1ccc(C23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"15314.0";"nM";"4.82";"";"";"UO_0000065";"9.69";"0.18";"-3.62";"20.01";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4127263";"";"0";"300.47";"0";"3.48";"2b";"S=C(NCc1ccccc1)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"34.0";"nM";"7.47";"";"";"UO_0000065";"24.86";"0.49";"3.99";"31.04";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL50";"QUERCETIN";"3";"302.24";"0";"1.99";"15";"O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12";"IC50";"'='";"33540.0";"nM";"4.47";"";"";"UO_0000065";"14.80";"0.28";"2.48";"3.41";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL2313177";"";"0";"390.48";"0";"3.48";"7-39";"Cc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3ccc(F)cc3)CC2)c(C)c1";"IC50";"'='";"290.0";"nM";"6.54";"";"";"UO_0000065";"16.74";"0.33";"3.06";"9.83";"False";"CHEMBL2318866";"Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2311251";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3263287";"";"0";"442.65";"0";"4.02";"1a";"O=C(NCCNC(=O)NCC12CC3CC(CC(C3)C1)C2)NCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"179.2";"nM";"6.75";"";"";"UO_0000065";"15.24";"0.29";"2.73";"8.20";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3263301";"";"0";"442.65";"0";"4.01";"2d";"O=C(NCCCCNC(=O)NC1C2CC3CC(C2)CC1C3)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"10.4";"nM";"7.98";"";"";"UO_0000065";"18.03";"0.34";"3.97";"9.70";"False";"CHEMBL3270578";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured at 5 mins post substrate addition by fluorescence assay in presence of 0.1 mg/mL BSA";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3259769";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL1300445";"";"0";"297.40";"0";"3.92";"47";"COc1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)cc1";"IC50";"'='";"430.0";"nM";"6.37";"";"";"UO_0000065";"21.41";"0.40";"2.45";"16.61";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4102078";"";"0";"324.16";"0";"3.62";"14";"O=C(O)c1ccc(CNC(=O)c2ccc(Cl)c(Cl)c2)cc1";"IC50";"'='";"10500.0";"nM";"4.98";"";"";"UO_0000065";"15.36";"0.32";"1.36";"7.50";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4067074";"";"0";"388.49";"0";"2.74";"45";"CC(=O)NS(=O)(=O)c1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)cc1";"IC50";"'='";"12700.0";"nM";"4.90";"";"";"UO_0000065";"12.60";"0.25";"2.16";"5.30";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4094881";"";"0";"364.44";"0";"2.70";"55";"CC(C)(C)c1ccc(C(=O)NCc2ccc(S(N)(=O)=O)cc2F)cc1";"IC50";"'='";"137.0";"nM";"6.86";"";"";"UO_0000065";"18.83";"0.37";"4.16";"7.69";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL1257516";"";"0";"325.41";"0";"3.36";"BDBM50327812";"CCC(=O)N1CCC(NC(=O)Nc2ccc3ccccc3c2)CC1";"IC50";"'='";"3.0";"nM";"8.52";"";"377011";"UO_0000065";"26.19";"0.48";"5.16";"13.87";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1256165";"";"0";"276.34";"0";"1.60";"BDBM50327839";"CCC(=O)N1CCC(NC(=O)Nc2cccnc2)CC1";"IC50";"'='";"3800.0";"nM";"5.42";"";"377012";"UO_0000065";"19.61";"0.37";"3.82";"7.29";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3222119";"";"0";"460.60";"0";"2.49";"4d";"CS(=O)(=O)N1CCN(C(=O)c2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)CC1";"IC50";"'='";"1.0";"nM";"9.00";"";"";"UO_0000065";"19.54";"0.38";"6.51";"9.11";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL3222129";"";"0";"467.65";"0";"4.55";"8b";"CC(=O)N1CCN(CCCCOc2cccc(NC(=O)CC34CC5CC(CC(C5)C3)C4)c2)CC1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"19.72";"0.37";"4.67";"14.90";"False";"CHEMBL3223384";"Inhibition of human recombinant soluble epoxide hydrolase using cyano(6-methoxy-naphthalen-2-yl)methyl-trans-[(3-phenyloxiran-2-yl)methyl]carbonate as substrate after 5 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3217451";"1";"Scientific Literature";"MedChemComm";"2012";"None"
"CHEMBL4204496";"";"0";"680.88";"3";"2.65";"25";"CC(=O)O[C@H]([C@H]1C[C@@H](C)[C@H]2[C@@](O)(O1)[C@H](O)[C@@]1(C)[C@@H]3CC[C@H]4C(C)(C)[C@@H](O[C@@H]5OC[C@@H](O)[C@H](O)[C@H]5O)CC[C@@]45C[C@@]35CC[C@]21C)C(C)(C)O";"Inhibition";"'='";"66.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4191389";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate at 100 uM measured for 1 hr by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4211861";"";"0";"632.84";"1";"3.70";"2";"COC(C)(C)[C@H]1O[C@@]23O[C@@H]1C[C@@H](C)[C@@H]2[C@@]1(C)CC[C@@]24C[C@@]25CC[C@H](O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]3O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4191391";"Competitive inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL3764209";"";"0";"395.38";"0";"4.17";"6c";"CCC(Cc1ccc(C(=O)NCc2ccccc2OC(F)(F)F)cc1)C(=O)O";"Inhibition";"'='";"23.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3767858";"Inhibition of human recombinant sEH using PHOME as substrate at 10 uM preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL4294239";"";"0";"642.70";"2";"6.37";"8";"COc1cc(C(=O)NS(=O)(=O)c2cccc(C(F)(F)F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12";"IC50";"'='";"1490.0";"nM";"5.83";"";"";"UO_0000065";"9.07";"0.18";"-0.54";"4.92";"False";"CHEMBL4256761";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by spectrofluorimetry";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL3103819";"";"0";"442.56";"0";"3.24";"29";"CC(C)(C)ONC(=O)C(=O)Nc1ccc(CNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"19.0";"nM";"7.72";"";"";"UO_0000065";"17.45";"0.33";"4.48";"7.11";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL4126229";"";"0";"358.60";"0";"4.49";"4c";"S=C(NCC12CC3CC(CC(C3)C1)C2)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"902.0";"nM";"6.04";"";"";"UO_0000065";"16.86";"0.33";"1.55";"25.12";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4130007";"";"0";"372.62";"1";"5.02";"3d";"CC(NC(=S)NC12CC3CC(CC(C3)C1)C2)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"60.3";"nM";"7.22";"";"";"UO_0000065";"19.38";"0.38";"2.20";"30.01";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4126585";"";"0";"372.62";"1";"5.17";"3b";"CC12CC3CC(C)(C1)CC(NC(=S)NC14CC5CC(CC(C5)C1)C4)(C3)C2";"IC50";"'='";"16.1";"nM";"7.79";"";"";"UO_0000065";"20.91";"0.41";"2.62";"32.39";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4126432";"";"0";"314.50";"0";"3.52";"2c";"S=C(NCCc1ccccc1)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"8.2";"nM";"8.09";"";"";"UO_0000065";"25.71";"0.50";"4.57";"33.61";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4130205";"";"0";"332.49";"0";"4.86";"1j";"CC12CC3CC(C)(C1)CC(NC(=S)Nc1cccc(F)c1)(C3)C2";"IC50";"'='";"58.0";"nM";"7.24";"";"";"UO_0000065";"21.76";"0.43";"2.38";"30.08";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4126645";"";"0";"328.53";"0";"3.91";"1g";"S=C(NCCc1ccccc1)NCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"133.0";"nM";"6.88";"";"";"UO_0000065";"20.93";"0.41";"2.97";"28.58";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1569169";"";"0";"328.52";"0";"4.67";"1e";"CC(N=C(S)NCc1ccccc1)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"234.0";"nM";"6.63";"";"";"UO_0000065";"20.18";"0.39";"1.96";"27.19";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4087689";"";"0";"309.29";"0";"3.64";"4";"COc1ccc(CNC(=O)c2ccccc2)c(C(F)(F)F)c1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"28.13";"0.54";"5.06";"22.69";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4072536";"";"0";"411.40";"1";"5.10";"20";"COc1ccc(CNC(=O)c2ccc(F)c(OC3CCCC3)c2)c(C(F)(F)F)c1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"22.84";"0.44";"4.30";"19.76";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4212729";"";"0";"636.82";"2";"2.09";"7";"C[C@@H]1[C@H]2OC(C)(C)[C@@H](O)[C@@]2(O)O[C@H]2[C@H](O)[C@@]3(C)[C@@H]4CC[C@H]5C(C)(C)[C@@H](O[C@@H]6OC[C@@H](O)[C@H](O)[C@H]6O)CC[C@@]56C[C@@]46CC[C@]3(C)[C@@H]12";"IC50";"'='";"4400.0";"nM";"5.36";"";"";"UO_0000065";"8.41";"0.16";"3.27";"3.38";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"7.8";"nM";"8.11";"";"";"UO_0000065";"20.65";"0.40";"2.87";"10.34";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4063138";"";"0";"364.32";"0";"3.14";"9";"COc1ccc(CNC(=O)c2ccc3c(c2)NC(=O)C3)c(C(F)(F)F)c1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"23.39";"0.45";"5.38";"12.64";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL3322798";"";"0";"486.65";"0";"2.65";"BDBM50057421";"CCCCNC(=O)C(=O)NCCCC/C=C\CCCCCCC(=O)OCCOCCOCCO";"IC50";"'>'";"500.0";"nM";"";"";"423457";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4068980";"";"0";"213.28";"0";"3.01";"6";"CC(C)=C/C=C1\C(=O)N(C)c2ccccc21";"Inhibition";"'='";"77.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4010815";"Inhibition of sEH (unknown origin) at 100 uM using PHOME as substrate after 40 mins by fluorescence photometric method relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL3763787";"";"0";"351.32";"0";"3.65";"16c";"O=C(O)CCc1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1";"IC50";"'='";"9000.0";"nM";"5.05";"";"";"UO_0000065";"14.36";"0.28";"1.40";"7.60";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL1076184";"CIMIRACEMATE A";"0";"358.35";"0";"2.18";"2";"COc1ccc(/C=C/C(=O)OCC(=O)Cc2ccc(O)c(O)c2)cc1O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4098909";"";"0";"324.42";"0";"3.87";"40";"CC(=O)Nc1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)cc1";"IC50";"'='";"1120.0";"nM";"5.95";"";"";"UO_0000065";"18.34";"0.34";"2.08";"10.22";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4100178";"";"0";"311.43";"0";"4.31";"48";"CCOc1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)cc1";"IC50";"'='";"570.0";"nM";"6.24";"";"";"UO_0000065";"20.05";"0.37";"1.93";"16.29";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4092436";"";"0";"351.37";"0";"4.81";"50";"CC(C)(C)c1ccc(C(=O)NCc2ccc(OC(F)(F)F)cc2)cc1";"IC50";"'='";"220.0";"nM";"6.66";"";"";"UO_0000065";"18.95";"0.36";"1.85";"17.37";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL3322816";"";"0";"378.52";"0";"2.45";"BDBM50057502";"CCCCNC(=O)C(=O)NCCCC/C=C\CCCCCCc1nnn[nH]1";"IC50";"'>'";"500.0";"nM";"";"";"326394";"UO_0000065";"";"";"";"";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4060303";"";"0";"199.25";"0";"2.99";"4";"CC(C)=C/C=C1/C(=O)Nc2ccccc21";"IC50";"'='";"1000.0";"nM";"6.00";"";"";"UO_0000065";"30.11";"0.55";"3.01";"20.62";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4067990";"";"0";"327.28";"0";"3.78";"5";"COc1ccc(CNC(=O)c2ccc(F)cc2)c(C(F)(F)F)c1";"IC50";"'='";"2.8";"nM";"8.55";"";"";"UO_0000065";"26.13";"0.51";"4.77";"22.31";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL3633669";"";"0";"303.41";"0";"3.00";"3d";"Cc1cc(CNC(=O)NCC23CC4CC(CC(C4)C2)C3)on1";"IC50";"'='";"6.7";"nM";"8.17";"";"";"UO_0000065";"26.94";"0.51";"5.17";"12.17";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3628782";"";"0";"438.55";"1";"5.93";"29";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C2CCCCC2)cc1)C(C)(C)C";"IC50";"'='";"23.0";"nM";"7.64";"";"";"UO_0000065";"17.42";"0.35";"1.71";"9.96";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628773";"";"0";"546.73";"2";"8.13";"20";"CCCCOP(=O)(OCCCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"26.0";"nM";"7.58";"";"";"UO_0000065";"13.87";"0.27";"-0.54";"9.89";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628414";"";"0";"528.61";"2";"7.04";"8";"CCOP(=O)(OCC)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)c1ccc(F)cc1";"IC50";"'='";"120.0";"nM";"6.92";"";"";"UO_0000065";"13.09";"0.26";"-0.12";"9.03";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL184238";"URB-597";"1";"338.41";"0";"3.87";"URB597";"NC(=O)c1cccc(-c2cccc(OC(=O)NC3CCCCC3)c2)c1";"IC50";"'='";"1100.0";"nM";"5.96";"";"";"UO_0000065";"17.61";"0.33";"2.09";"7.32";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL3322812";"";"0";"413.59";"0";"3.35";"BDBM50057491";"CCCCCNC(=O)NCCCC/C=C\CCCCCS(=O)(=O)c1ncn[nH]1";"IC50";"'='";"23.0";"nM";"7.64";"";"423472";"UO_0000065";"18.47";"0.37";"4.29";"6.54";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3104622";"";"0";"504.51";"1";"4.20";"25";"CC(=O)Nc1ccccc1C(=O)N1CCC2(CC1)CN(C(=O)Nc1ccc(C(F)(F)F)cc1)CCO2";"IC50";"'='";"0.8";"nM";"9.10";"";"";"UO_0000065";"18.03";"0.35";"4.90";"10.00";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL1946170";"REGORAFENIB";"4";"482.82";"1";"5.69";"BAY 73-4506, Stivarga";"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"";"UO_0000065";"19.26";"0.38";"3.61";"10.07";"False";"CHEMBL2399731";"Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL2424991";"";"0";"453.56";"0";"3.61";"6d";"COc1ccc(C(=O)N2CCC(c3cc(C)nn3-c3ccc(S(C)(=O)=O)cc3)CC2)cc1";"Inhibition";"'='";"15.15";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL1946170";"REGORAFENIB";"4";"482.82";"1";"5.69";"BAY 73-4506, Stivarga";"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1";"Ratio IC50";"'='";"24.0";"";"";"";"";"";"";"";"";"";"False";"CHEMBL2399714";"Ratio of compound IC50 to sorafenib IC50 for human recombinant soluble epoxide hydrolase";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396585";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL1358";"FULVESTRANT";"4";"606.78";"2";"8.68";"15G10";"C[C@]12CC[C@@H]3c4ccc(O)cc4C[C@@H](CCCCCCCCC[S+]([O-])CCCC(F)(F)C(F)(F)F)[C@H]3[C@@H]1CC[C@@H]2O";"IC50";"'='";"6.0";"nM";"8.22";"";"";"UO_0000065";"13.55";"0.27";"-0.46";"14.29";"False";"CHEMBL2400592";"Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonate) as substrate preincubated for 5 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2396615";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2013";"None"
"CHEMBL3633667";"";"0";"395.50";"0";"4.37";"3b";"COc1ccc(-c2cc(CNC(=O)NCC34CC5CC(CC(C5)C3)C4)no2)cc1";"IC50";"'='";"12.9";"nM";"7.89";"";"";"UO_0000065";"19.95";"0.37";"3.52";"10.33";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3633672";"";"0";"383.47";"0";"4.50";"3g";"O=C(NCc1cc(-c2cccc(F)c2)no1)NCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"16.6";"nM";"7.78";"";"";"UO_0000065";"20.29";"0.38";"3.28";"11.58";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3633673";"";"0";"383.47";"0";"4.50";"3h";"O=C(NCc1cc(-c2ccc(F)cc2)no1)NCC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"10.5";"nM";"7.98";"";"";"UO_0000065";"20.81";"0.39";"3.48";"11.88";"False";"CHEMBL3637430";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate by kinetic fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632545";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3629065";"";"0";"476.60";"1";"6.89";"33";"CCOP(=O)(OCC)C(Nc1ccc(NC(=O)C23CC4CC(CC(C4)C2)C3)cc1)C(C)(C)C";"IC50";"'='";"37.0";"nM";"7.43";"";"";"UO_0000065";"15.59";"0.31";"0.54";"9.69";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL3628775";"";"0";"614.77";"2";"8.93";"22";"CC(C)(C)C(Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1)P(=O)(OCc1ccccc1)OCc1ccccc1";"IC50";"'='";"42.0";"nM";"7.38";"";"";"UO_0000065";"12.00";"0.23";"-1.55";"9.62";"False";"CHEMBL3631996";"Inhibition of recombinant human sEH expressed in baculovirus infected insect Sf9 cells using CMNPC as substrate assessed as 6-methoxy-2-naphthadehyde level after 10 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3627639";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"CHEMBL3308860"
"CHEMBL4218633";"";"0";"632.79";"1";"2.38";"4";"C[C@@H]1C[C@]23OCC(C)(O)[C@H]2O[C@@]2(O3)[C@H]1[C@@]1(C)CC[C@@]34C[C@@]35CC[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]2O";"IC50";"'='";"14600.0";"nM";"4.84";"";"";"UO_0000065";"7.64";"0.15";"2.46";"3.28";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL3634702";"";"0";"608.55";"3";"-2.51";"15";"COc1cc(O[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)c2c(c1)C(=O)c1cc(C)cc(O)c1C2=O";"IC50";"'='";"40600.0";"nM";"4.39";"";"";"UO_0000065";"7.22";"0.14";"6.90";"1.81";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"10.0";"nM";"8.00";"";"";"UO_0000065";"20.38";"0.39";"2.76";"10.20";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3634697";"";"0";"314.29";"0";"2.20";"1; 7-methoxy-obtusifolin";"COc1ccc2c(c1O)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL21241";"GW7647";"0";"502.77";"2";"7.28";"GW7647";"CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(=O)O";"IC50";"";"";"";"";"";"Not Determined";"";"";"";"";"";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764792";"";"0";"437.46";"0";"4.78";"14b";"CCOC(=O)C(CC)Cc1ccc(C(=O)NCc2ccc(OC)cc2C(F)(F)F)cc1";"IC50";"'='";"30.0";"nM";"7.52";"";"";"UO_0000065";"17.20";"0.33";"2.74";"11.64";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL4204107";"";"0";"576.73";"2";"1.45";"8";"C[C@@H]1CC(=O)[C@H](O)[C@]2(O)[C@H]1[C@@]1(C)CC[C@@]34C[C@@]35CC[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]2O";"Inhibition";"'='";"69.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4191389";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate at 100 uM measured for 1 hr by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL1257757";"";"0";"303.41";"0";"2.77";"BDBM50327818";"CCC(=O)N1CCC(NC(=O)Nc2ccc(CC)cc2)CC1";"IC50";"'='";"8.3";"nM";"8.08";"";"377016";"UO_0000065";"26.63";"0.50";"5.31";"13.15";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL464229";"";"0";"492.43";"2";"-0.62";"16";"COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc2c(c1O)C(=O)c1c(cc(C)c(O)c1OC)C2=O";"Inhibition";"'='";"57.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3634699";"";"0";"596.54";"3";"-2.03";"10";"COc1cc(O[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)c2c(O)c3c(=O)cc(C)oc3cc2c1";"IC50";"'='";"37500.0";"nM";"4.43";"";"";"UO_0000065";"7.42";"0.14";"6.46";"1.86";"False";"CHEMBL3635709";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL2397136";"";"0";"420.51";"0";"4.32";"BDBM50436432";"CNC(=O)c1cc(Oc2ccc(NC(=O)NC34CC5CC(CC(C5)C3)C4)cc2)ccn1";"IC50";"'='";"0.5";"nM";"9.30";"";"301045";"UO_0000065";"22.12";"0.41";"4.98";"10.07";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL223281";"";"0";"448.69";"1";"6.50";"AUDA";"CCCCOC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"7.8";"nM";"8.11";"";"";"UO_0000065";"18.07";"0.35";"1.61";"12.02";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4211037";"";"0";"495.45";"0";"3.91";"27";"O=C(O)CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"17.56";"0.34";"4.79";"6.90";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4206149";"";"0";"481.47";"0";"3.82";"26";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)NCCO)cc2)CC1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"18.07";"0.35";"4.88";"7.99";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4217146";"";"0";"360.45";"0";"3.71";"5";"O=C(NC1CCCCC1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"6.0";"nM";"8.22";"";"";"UO_0000065";"22.81";"0.43";"4.51";"9.38";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1257632";"";"0";"295.43";"0";"2.41";"BDBM50327810";"CCC(=O)N1CCC(NC(=O)NC2CCCCCC2)CC1";"IC50";"'='";"3.9";"nM";"8.41";"";"377006";"UO_0000065";"28.46";"0.55";"6.00";"13.69";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1258669";"";"0";"377.79";"0";"3.88";"BDBM50327811";"CCC(=O)N1CCC(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)CC1";"IC50";"'='";"4.1";"nM";"8.39";"";"377038";"UO_0000065";"22.20";"0.46";"4.51";"13.65";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1258784";"";"0";"343.35";"0";"3.23";"BDBM50327821";"CCC(=O)N1CCC(NC(=O)Nc2cccc(C(F)(F)F)c2)CC1";"IC50";"'='";"17.0";"nM";"7.77";"";"377040";"UO_0000065";"22.63";"0.44";"4.54";"12.65";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL1257756";"";"0";"289.38";"0";"2.52";"BDBM50327828";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C)cc2)CC1";"IC50";"'='";"43.0";"nM";"7.37";"";"377015";"UO_0000065";"25.46";"0.48";"4.85";"11.99";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3763987";"";"0";"329.37";"0";"3.41";"7c";"CCC(Cc1ccc(C(=O)NCc2ccc(F)cc2)cc1)C(=O)O";"Inhibition";"'='";"28.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3767858";"Inhibition of human recombinant sEH using PHOME as substrate at 10 uM preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL497001";"ALOIN";"0";"418.40";"1";"-0.89";"2";"O=C1c2c(O)cccc2C([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cc(CO)cc(O)c21";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3620673";"Mixed-type inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL2336315";"";"0";"585.60";"2";"7.11";"8m";"COc1cc(-c2nc3ccc(F)cn3c2NC2CCCC2)ccc1OCCCNC(=O)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"42.0";"nM";"7.38";"";"";"UO_0000065";"12.60";"0.24";"0.27";"8.30";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL2336314";"";"0";"602.06";"2";"7.63";"8l";"COc1cc(-c2nc3ccc(Cl)cn3c2NC2CCCC2)ccc1OCCCNC(=O)Nc1ccc(C(F)(F)F)cc1";"IC50";"'='";"92.0";"nM";"7.04";"";"";"UO_0000065";"11.69";"0.23";"-0.59";"7.91";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL93";"ZILEUTON";"4";"236.30";"0";"2.73";"Zileuton";"CC(c1cc2ccccc2s1)N(O)C(N)=O";"IC50";"'='";"591.0";"nM";"6.23";"";"";"UO_0000065";"26.36";"0.53";"3.50";"9.36";"False";"CHEMBL2344666";"Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2331454";"1";"Scientific Literature";"J. Med. Chem.";"2013";"None"
"CHEMBL3322827";"";"0";"420.54";"0";"2.84";"BDBM50057639";"CCCCNC(=O)C(=O)NCCCCCOc1cccc2sc(NC(C)=O)nc12";"IC50";"'>'";"500.0";"nM";"";"";"423486";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4111532";"";"0";"449.60";"0";"4.03";"BDBM242781";"CCCCCNC(=O)NCCCC/C=[O+]\CCOc1cccc2sc(NC(C)=O)nc12";"IC50";"'='";"282.0";"nM";"6.55";"";"423487";"UO_0000065";"14.57";"0.29";"2.52";"6.32";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4126537";"";"0";"348.94";"1";"5.38";"1s";"CC12CC3CC(C)(C1)CC(NC(=S)Nc1ccc(Cl)cc1)(C3)C2";"IC50";"'='";"1048.0";"nM";"5.98";"";"";"UO_0000065";"17.14";"0.36";"0.60";"24.85";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL597365";"";"0";"398.48";"0";"3.33";"BDBM158478";"CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cccc(F)c32)c1C";"IC50";"'>'";"10000.0";"nM";"";"";"301031";"UO_0000065";"";"";"";"";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4101942";"";"0";"386.41";"0";"3.37";"24";"CCCC(=O)N1CCC(C(=O)NCc2ccc(OC)cc2C(F)(F)F)CC1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"21.73";"0.42";"5.03";"14.32";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4083949";"";"0";"372.39";"0";"2.98";"23/MPPA";"CCC(=O)N1CCC(C(=O)NCc2ccc(OC)cc2C(F)(F)F)CC1";"IC50";"'='";"2.1";"nM";"8.68";"";"";"UO_0000065";"23.30";"0.46";"5.70";"14.80";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL3899098";"";"0";"456.85";"1";"5.57";"BDBM158484";"O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)NC1CCC(Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"0.5";"nM";"9.30";"";"301038";"UO_0000065";"20.36";"0.41";"3.73";"10.61";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3114596";"";"0";"404.43";"0";"4.81";"18";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2cccc(C(F)(F)F)c2)CC1";"IC50";"'='";"15.8";"nM";"7.80";"";"";"UO_0000065";"19.29";"0.37";"2.99";"18.77";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3114591";"";"0";"370.88";"0";"4.45";"13";"O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(Oc2ccc(Cl)cc2)CC1";"IC50";"'='";"22.4";"nM";"7.65";"";"";"UO_0000065";"20.63";"0.40";"3.20";"18.40";"False";"CHEMBL3118265";"Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3112438";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"None"
"CHEMBL3104430";"";"0";"437.42";"0";"3.84";"27";"O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccco3)CC2)C1";"IC50";"'='";"5.4";"nM";"8.27";"";"";"UO_0000065";"18.90";"0.36";"4.43";"11.02";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3104619";"";"0";"481.90";"0";"4.90";"22";"O=C(Nc1ccc(C(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccccc3Cl)CC2)C1";"IC50";"'='";"1.4";"nM";"8.85";"";"";"UO_0000065";"18.37";"0.37";"3.95";"14.31";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3102876";"";"0";"481.45";"0";"4.26";"19";"O=C(Nc1ccc(OC(F)(F)F)cc1)N1CCOC2(CCN(C(=O)c3ccccc3F)CC2)C1";"IC50";"'='";"1.1";"nM";"8.96";"";"";"UO_0000065";"18.61";"0.36";"4.70";"12.60";"False";"CHEMBL3106763";"Inhibition of human recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substrate preincubated for 30 mins followed by substrate addition measured after 20 to 45 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102795";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"CHEMBL3308860"
"CHEMBL3322821";"";"0";"396.60";"1";"5.44";"BDBM50057633";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1noc(=S)[nH]1";"IC50";"'='";"31.0";"nM";"7.51";"";"423482";"UO_0000065";"18.93";"0.38";"2.07";"9.05";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4079802";"";"0";"393.41";"0";"4.97";"2";"COc1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1OC1CCCC1";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"19.89";"0.38";"2.85";"16.45";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4091025";"";"0";"366.34";"0";"3.60";"10";"COc1ccc(CNC(=O)c2ccc(NC(C)=O)cc2)c(C(F)(F)F)c1";"IC50";"'='";"44.0";"nM";"7.36";"";"";"UO_0000065";"20.08";"0.39";"3.76";"10.91";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL1330331";"";"0";"283.33";"0";"2.90";"4";"COc1cccc(CNc2nc3ccccc3n2C)c1O";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL2039369";"Inhibition of soluble epoxide hydrolase using (3-Phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester) as substrate incubated for 15 mins prior to substrate addition measured every min for 15 mins by fluorometry";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2034900";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2012";"None"
"CHEMBL3634702";"";"0";"608.55";"3";"-2.51";"15";"COc1cc(O[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)c2c(c1)C(=O)c1cc(C)cc(O)c1C2=O";"Inhibition";"'='";"51.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3635708";"Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation at 50 uM by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3632595";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL3895613";"";"0";"451.44";"0";"4.46";"BDBM158485";"CNC(=O)c1ccc(OC2CCC(NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"301040";"UO_0000065";"20.60";"0.40";"4.84";"10.49";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL2397146";"";"0";"470.88";"0";"4.63";"BDBM50436438";"CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)cn1";"IC50";"'='";"0.5";"nM";"9.30";"";"301048";"UO_0000065";"19.75";"0.40";"4.67";"10.07";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322804";"";"0";"437.65";"0";"4.74";"BDBM50057450";"CCCCCNC(=O)NCCCC/C=C\CCCCCNS(=O)(=O)c1ccccc1";"IC50";"'='";"32.0";"nM";"7.50";"";"326385";"UO_0000065";"17.13";"0.34";"2.75";"8.59";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL1258670";"";"0";"343.35";"0";"3.23";"BDBM50327814";"CCC(=O)N1CCC(NC(=O)Nc2ccc(C(F)(F)F)cc2)CC1";"IC50";"'='";"0.7";"nM";"9.15";"";"377039";"UO_0000065";"26.66";"0.52";"5.92";"14.90";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3103809";"";"0";"322.41";"0";"1.50";"15";"O=C(NOC1CCCCO1)C(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3103803";"";"0";"373.41";"0";"2.08";"9";"O=C(NOCc1ccc([N+](=O)[O-])cc1)C(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'>'";"10000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3103800";"";"0";"328.41";"0";"2.18";"6";"O=C(NOCc1ccccc1)C(=O)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"50.0";"nM";"7.30";"";"";"UO_0000065";"22.23";"0.42";"5.12";"10.83";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL3103822";"";"0";"470.57";"0";"2.97";"32";"O=C(NCc1ccc(NC(=O)C(=O)NOC2CCCCO2)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"19.0";"nM";"7.72";"";"";"UO_0000065";"16.41";"0.31";"4.75";"6.56";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL83103";"";"0";"195.22";"0";"2.62";"f";"c1cncc(-c2nc3ccccc3[nH]2)c1";"IC50";"'='";"91000.0";"nM";"4.04";"";"";"UO_0000065";"20.70";"0.37";"1.42";"9.72";"False";"CHEMBL3102108";"Inhibition of recombinant soluble epoxide hydrolase (unknown origin) using PHOME as substrate incubated 15 mins prior to substrate addition measured for 30 minutes by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3098011";"1";"Scientific Literature";"ACS Med. Chem. Lett.";"2013";"None"
"CHEMBL4087682";"";"0";"345.83";"0";"4.27";"28";"CC(C)(C)c1ccc(C(=O)NCc2ccc(C(=O)O)c(Cl)c2)cc1";"Inhibition";"'='";"50.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4090057";"";"0";"213.28";"0";"3.01";"5";"CC(C)=C/C=C1/C(=O)N(C)c2ccccc21";"Inhibition";"";"";"";"";"";"Dose-dependent effect";"";"";"";"";"";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL3677981";"";"0";"481.82";"1";"6.28";"BDBM158490";"O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N[C@H]1CC[C@H](Oc2ccc(C(F)(F)F)cn2)CC1";"IC50";"'='";"9.0";"nM";"8.05";"";"301046";"UO_0000065";"16.70";"0.34";"1.77";"12.72";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322796";"";"0";"513.76";"2";"5.83";"1";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCC(=O)OCCOCCOCCO)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"True";"CHEMBL3376213";"Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3352195";"1";"Scientific Literature";"J. Med. Chem.";"2014";"None"
"CHEMBL4060303";"";"0";"199.25";"0";"2.99";"4";"CC(C)=C/C=C1/C(=O)Nc2ccccc21";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4010819";"Competitive inhibition of sEH (unknown origin) at 0.78 to 6.25 uM using PHOME as substrate measured for 30 mins by Lineweaver-burk plot method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4090057";"";"0";"213.28";"0";"3.01";"5";"CC(C)=C/C=C1/C(=O)N(C)c2ccccc21";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4010819";"Competitive inhibition of sEH (unknown origin) at 0.78 to 6.25 uM using PHOME as substrate measured for 30 mins by Lineweaver-burk plot method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4068980";"";"0";"213.28";"0";"3.01";"6";"CC(C)=C/C=C1\C(=O)N(C)c2ccccc21";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4010819";"Competitive inhibition of sEH (unknown origin) at 0.78 to 6.25 uM using PHOME as substrate measured for 30 mins by Lineweaver-burk plot method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4208985";"";"0";"660.85";"1";"3.61";"9";"CC(=O)OC(C)(C)[C@H]1O[C@@]23O[C@@H]1C[C@@H](C)[C@@H]2[C@@]1(C)CC[C@@]24C[C@@]25CC[C@H](O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]3O";"Inhibition";"'='";"76.7";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4191389";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate at 100 uM measured for 1 hr by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4204107";"";"0";"576.73";"2";"1.45";"8";"C[C@@H]1CC(=O)[C@H](O)[C@]2(O)[C@H]1[C@@]1(C)CC[C@@]34C[C@@]35CC[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]2O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4191393";"Non-competitive inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4214874";"";"0";"476.46";"1";"5.46";"17";"Cc1nnc(-c2ccc(O[C@H]3CC[C@H](NC(=O)Nc4ccc(OC(F)(F)F)cc4)CC3)cc2)o1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"17.63";"0.34";"2.94";"8.52";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL63";"ROLIPRAM";"2";"275.35";"0";"2.62";"ROLIPRAM";"COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1";"IC50";"'>'";"100000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4211861";"";"0";"632.84";"1";"3.70";"2";"COC(C)(C)[C@H]1O[C@@]23O[C@@H]1C[C@@H](C)[C@@H]2[C@@]1(C)CC[C@@]24C[C@@]25CC[C@H](O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]3O";"Inhibition";"'='";"75.6";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4191389";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate at 100 uM measured for 1 hr by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4207503";"";"0";"636.82";"2";"2.00";"5";"C[C@@H]1C[C@H]([C@@H](O)C(C)(C)O)O[C@]2(O)[C@H]1[C@@]1(C)CC[C@@]34C[C@@]35CC[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]2O";"IC50";"'='";"10700.0";"nM";"4.97";"";"";"UO_0000065";"7.81";"0.15";"2.97";"2.94";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL3906902";"";"0";"474.80";"0";"4.01";"BDBM181779";"O=C(NCc1ccc(Cl)cc1Cl)N1CC2(CCN2S(=O)(=O)c2ccc(Cl)cc2)C1";"IC50";"'='";"640.0";"nM";"6.19";"";"328786";"UO_0000065";"13.05";"0.29";"2.18";"8.88";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL2392736";"";"0";"291.42";"0";"3.40";"48";"Cc1csc(NC(=O)NC2C3CC4CC(C3)CC2C4)n1";"IC50";"'='";"710.0";"nM";"6.15";"";"";"UO_0000065";"21.10";"0.42";"2.75";"11.38";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL2392728";"";"0";"344.44";"0";"3.89";"40";"O=C(Nc1nnc(-c2cccs2)o1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"1575.0";"nM";"5.80";"";"";"UO_0000065";"16.85";"0.33";"1.91";"7.25";"False";"CHEMBL2394377";"Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins before substrate addition measured after 10 mins by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2390858";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2013";"None"
"CHEMBL4291038";"";"0";"458.37";"1";"7.13";"51";"Cc1cc(OCc2nc3ccccc3s2)ccc1NC(=O)Nc1ccc(Cl)c(Cl)c1";"IC50";"'='";"20.0";"nM";"7.70";"";"";"UO_0000065";"16.80";"0.35";"0.57";"12.17";"False";"CHEMBL4258027";"Inhibition of recombinant human sEH expressed in baculovirus infected Sf9 cells using PHOME as substrate preincubated for 10 mins followed by substrate addition and measured after 60 mins by fluorescence assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4257455";"1";"Scientific Literature";"MedChemComm";"2018";"None"
"CHEMBL4208985";"";"0";"660.85";"1";"3.61";"9";"CC(=O)OC(C)(C)[C@H]1O[C@@]23O[C@@H]1C[C@@H](C)[C@@H]2[C@@]1(C)CC[C@@]24C[C@@]25CC[C@H](O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]3O";"IC50";"'='";"24000.0";"nM";"4.62";"";"";"UO_0000065";"6.99";"0.13";"1.01";"3.21";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4207503";"";"0";"636.82";"2";"2.00";"5";"C[C@@H]1C[C@H]([C@@H](O)C(C)(C)O)O[C@]2(O)[C@H]1[C@@]1(C)CC[C@@]34C[C@@]35CC[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]2O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4191391";"Competitive inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4217337";"";"0";"634.81";"2";"2.01";"18";"C[C@@H]1C[C@H]2O[C@@]3(O[C@H]2C(C)(C)O)[C@H](O)[C@@]2(C)C4=CC[C@H]5C(C)(C)[C@@H](O[C@@H]6OC[C@@H](O)[C@H](O)[C@H]6O)CC[C@@]56C[C@@]46C[C@@H](O)[C@]2(C)[C@@H]13";"IC50";"'='";"18500.0";"nM";"4.73";"";"";"UO_0000065";"7.46";"0.14";"2.72";"2.99";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4204496";"";"0";"680.88";"3";"2.65";"25";"CC(=O)O[C@H]([C@H]1C[C@@H](C)[C@H]2[C@@](O)(O1)[C@H](O)[C@@]1(C)[C@@H]3CC[C@H]4C(C)(C)[C@@H](O[C@@H]5OC[C@@H](O)[C@H](O)[C@H]5O)CC[C@@]45C[C@@]35CC[C@]21C)C(C)(C)O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4191391";"Competitive inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4088582";"";"0";"345.83";"0";"4.27";"31";"CC(C)(C)c1ccc(C(=O)NCc2ccc(C(=O)O)cc2Cl)cc1";"IC50";"'='";"170.0";"nM";"6.77";"";"";"UO_0000065";"19.57";"0.39";"2.50";"10.20";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4087681";"";"0";"412.84";"1";"5.07";"56";"CC(C)(C)c1ccc(C(=O)NCc2ccc(NC(=O)C(F)(F)F)cc2Cl)cc1";"IC50";"'='";"8.9";"nM";"8.05";"";"";"UO_0000065";"19.50";"0.39";"2.98";"13.83";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4096750";"";"0";"255.27";"0";"2.31";"5";"O=C(O)c1ccc(CNC(=O)c2ccccc2)cc1";"Inhibition";"'='";"16.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL2425012";"";"0";"418.56";"0";"3.27";"9d";"CCCCNC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(C)(=O)=O)cc2)CC1";"IC50";"'='";"269.0";"nM";"6.57";"";"";"UO_0000065";"15.70";"0.31";"3.30";"7.79";"False";"CHEMBL2427204";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2425010";"";"0";"404.54";"0";"2.88";"9b";"CCCNC(=O)N1CCC(c2cc(C)nn2-c2ccc(S(C)(=O)=O)cc2)CC1";"Inhibition";"'='";"54.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL2424995";"";"0";"458.97";"0";"3.50";"7b";"Cc1cc(C2CCN(C(=O)c3ccc(Cl)cc3)CC2)n(-c2ccc(S(N)(=O)=O)cc2)n1";"Inhibition";"'='";"32.5";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL2427205";"Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate at 100 uM incubated for 15 mins prior to substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL2424549";"1";"Scientific Literature";"Med Chem Res";"2013";"None"
"CHEMBL4130236";"";"0";"530.89";"2";"6.19";"6g";"S=C(NCCCCCCCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"9.8";"nM";"8.01";"";"";"UO_0000065";"15.09";"0.30";"1.82";"16.64";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4129529";"";"0";"372.62";"0";"4.88";"4d";"CC(NC(=S)NC1C2CC3CC(C2)CC1C3)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"7784.0";"nM";"5.11";"";"";"UO_0000065";"13.71";"0.27";"0.23";"21.23";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4128446";"";"0";"448.72";"1";"7.05";"3i";"S=C(NCCC12CC3CC(CC(C3)C1)C2)Nc1ccc(C23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"5334.0";"nM";"5.27";"";"";"UO_0000065";"11.75";"0.23";"-1.78";"21.92";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4129410";"";"0";"434.69";"1";"6.66";"3g";"S=C(NCC12CC3CC(CC(C3)C1)C2)Nc1ccc(C23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"5903.0";"nM";"5.23";"";"";"UO_0000065";"12.03";"0.23";"-1.43";"21.73";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4128645";"";"0";"358.60";"0";"4.64";"3c";"S=C(NCC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"20.8";"nM";"7.68";"";"";"UO_0000065";"21.42";"0.42";"3.04";"31.93";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4127816";"";"0";"344.57";"0";"4.39";"3a";"S=C(NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"11.2";"nM";"7.95";"";"";"UO_0000065";"23.07";"0.45";"3.56";"33.05";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4127443";"";"0";"320.89";"0";"4.60";"1r";"S=C(Nc1ccc(Cl)cc1)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"34.7";"nM";"7.46";"";"";"UO_0000065";"23.25";"0.49";"2.86";"31.00";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4128925";"";"0";"314.50";"0";"4.58";"1b";"CC(NC(=S)Nc1ccccc1)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"2592.0";"nM";"5.59";"";"";"UO_0000065";"17.76";"0.35";"1.01";"23.22";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1818421";"";"0";"344.33";"0";"3.85";"Figure 2B, R1C2";"CC(=O)C1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"12.0";"nM";"7.92";"";"";"UO_0000065";"23.00";"0.45";"4.07";"11.75";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL1818406";"";"0";"316.83";"0";"4.79";"26";"Cc1ccc(NC(=O)NC(C)CCc2ccccc2)cc1Cl";"IC50";"'='";"15.0";"nM";"7.82";"";"";"UO_0000065";"24.69";"0.49";"3.03";"19.02";"False";"CHEMBL1819920";"Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL1817626";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2011";"None"
"CHEMBL3236510";"";"0";"752.59";"3";"1.72";"10";"O=C(O[C@@H]1[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)O[C@H](CO)[C@H]1O)c1cc(O)c(O)c(O)c1";"IC50";"'='";"23810.0";"nM";"4.62";"";"";"UO_0000065";"6.14";"0.12";"2.90";"1.43";"False";"CHEMBL3243099";"Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3232869";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2014";"None"
"CHEMBL3677984";"";"0";"422.40";"0";"4.92";"BDBM158494";"O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"0.9";"nM";"9.05";"";"301051";"UO_0000065";"21.42";"0.41";"4.13";"10.32";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322798";"";"0";"486.65";"0";"2.65";"BDBM50057421";"CCCCNC(=O)C(=O)NCCCC/C=C\CCCCCCC(=O)OCCOCCOCCO";"IC50";"'>'";"500.0";"nM";"";"";"326376";"UO_0000065";"";"";"";"";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322800";"";"0";"425.61";"0";"4.43";"BDBM50057423";"CCCCCN(C)C(=O)N(C)CCCC/C=C\CCCCCCC(=O)NCC(=O)O";"IC50";"'>'";"500.0";"nM";"";"";"326379";"UO_0000065";"";"";"";"";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4094206";"";"0";"316.32";"0";"2.33";"22";"COc1ccc(CNC(=O)C2CCNCC2)c(C(F)(F)F)c1";"IC50";"'='";"370.0";"nM";"6.43";"";"";"UO_0000065";"20.33";"0.40";"4.10";"12.77";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4078857";"";"0";"380.37";"0";"3.99";"7";"CCC(=O)Nc1cccc(C(=O)NCc2ccc(OC)cc2C(F)(F)F)c1";"IC50";"'='";"3.7";"nM";"8.43";"";"";"UO_0000065";"22.17";"0.43";"4.44";"12.50";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4126549";"";"0";"446.73";"0";"3.85";"6a";"S=C(NCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"987.4";"nM";"6.01";"";"";"UO_0000065";"13.44";"0.27";"2.16";"12.48";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.35";"nM";"9.46";"";"";"UO_0000065";"24.09";"0.46";"4.22";"12.06";"False";"CHEMBL4190669";"Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate incubated for 5 mins followed by substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190176";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL3920376";"";"0";"450.00";"0";"3.47";"BDBM181778";"O=C(NC12CC3CC(CC(C3)C1)C2)N1CC2(CCN2S(=O)(=O)c2ccc(Cl)cc2)C1";"IC50";"'='";"2554.0";"nM";"5.59";"";"328785";"UO_0000065";"12.43";"0.25";"2.12";"8.02";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4215208";"";"0";"528.53";"2";"6.45";"24";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)OCc3ccccc3)cc2)CC1";"Ki";"'='";"43.0";"nM";"7.37";"";"";"UO_0000065";"13.94";"0.26";"0.92";"8.58";"False";"CHEMBL4187629";"Competitive inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using varying CMNPC substrate levels by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL3401631";"";"0";"436.55";"0";"4.45";"8";"CC1(C)[C@H](c2ccccc2)[C@H]1NC(=O)N1CCC(Oc2ccc(CCC(=O)O)cc2)CC1";"IC50";"'>'";"100.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL3406976";"Inhibition of recombinant human soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3400076";"1";"Scientific Literature";"Bioorg. Med. Chem. Lett.";"2015";"None"
"CHEMBL1258558";"";"0";"344.24";"0";"3.52";"BDBM50327844";"CCC(=O)N1CCC(NC(=O)Nc2cc(Cl)cc(Cl)c2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"377036";"UO_0000065";"27.30";"0.58";"5.88";"15.30";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3103811";"";"0";"385.46";"0";"2.14";"18";"CONC(=O)C(=O)Nc1ccc(CNC(=O)C23CC4CC(CC(C4)C2)C3)cc1";"IC50";"'='";"280.0";"nM";"6.55";"";"";"UO_0000065";"17.00";"0.32";"4.41";"6.79";"False";"CHEMBL3107383";"Inhibition of recombinant human sEH expressed in Sf9 cells using CMNPC as substrate assessed as release of 6-methoxy-2-naphthaldehyde preincubated for 10 mins before substrate addition measured after 10 mins by fluorometer analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"Sf9";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3102813";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2014";"CHEMBL3308860"
"CHEMBL2397148";"";"0";"438.40";"0";"4.80";"t-TUCB";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"";"UO_0000065";"21.44";"0.41";"4.60";"9.70";"False";"CHEMBL4187623";"Inhibition of soluble epoxide hydrolase (unknown origin)";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1552108";"";"0";"438.40";"0";"4.80";"c-TUCB";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"19.84";"0.38";"3.90";"8.98";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL249447";"";"0";"516.46";"3";"1.03";"3";"O=C(/C=C/c1ccc(O)c(O)c1)O[C@@H]1C[C@](O)(C(=O)O)C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@H]1O";"IC50";"'='";"2800.0";"nM";"5.55";"";"";"UO_0000065";"10.75";"0.20";"4.52";"2.63";"False";"CHEMBL4010816";"Inhibition of sEH (unknown origin) using PHOME as substrate after 40 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4060303";"";"0";"199.25";"0";"2.99";"4";"CC(C)=C/C=C1/C(=O)Nc2ccccc21";"Inhibition";"'='";"95.1";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4010815";"Inhibition of sEH (unknown origin) at 100 uM using PHOME as substrate after 40 mins by fluorescence photometric method relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4071682";"";"0";"344.32";"0";"2.25";"1";"COc1ccc(/C=C/C(=O)OCC(=O)c2ccc(O)c(O)c2)cc1O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4010817";"Mixed type inhibition of sEH (unknown origin) at 0.78 to 6.25 uM using PHOME as substrate measured for 30 mins by Lineweaver-burk plot method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL3322823";"";"0";"397.59";"0";"4.50";"BDBM50057635";"CCCCCNC(=O)NCCCC/C=C\CCCCCC1SC(=O)NC1=O";"IC50";"'='";"57.0";"nM";"7.24";"";"326397";"UO_0000065";"18.22";"0.37";"2.74";"8.30";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322822";"";"0";"396.60";"0";"4.54";"BDBM50057634";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1nsc(=O)[nH]1";"IC50";"'='";"231.0";"nM";"6.64";"";"326402";"UO_0000065";"16.73";"0.34";"2.10";"7.64";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322819";"";"0";"441.68";"1";"5.77";"BDBM50057630";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCC1=NOS(=O)N1)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"326407";"UO_0000065";"";"";"";"";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3917589";"";"0";"432.97";"0";"3.49";"BDBM181782";"O=C(NCCCc1ccccc1)[C@@H]1CCC12CN(S(=O)(=O)c1ccccc1Cl)C2";"IC50";"'='";"2792.0";"nM";"5.55";"";"328789";"UO_0000065";"12.83";"0.26";"2.06";"8.35";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3927620";"";"0";"440.35";"0";"3.21";"BDBM181787";"O=C(NCc1ccc(Cl)cc1Cl)N1CC2CN(S(=O)(=O)c3ccccc3)C2C1";"IC50";"'='";"238.0";"nM";"6.62";"";"328794";"UO_0000065";"15.04";"0.32";"3.41";"9.50";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3925348";"";"0";"420.30";"0";"3.72";"BDBM181789";"O=C(O)c1ccc(N2CC3CN(C(=O)NCc4ccc(Cl)cc4Cl)CC32)cc1";"IC50";"'='";"351.0";"nM";"6.46";"";"328796";"UO_0000065";"15.36";"0.31";"2.73";"8.86";"False";"CHEMBL3887292";"Enzyme Assay: Test compounds (1.6 mM stock in DMSO) were diluted 3 fold in series in DMSO and 0.8 microliters per well were added into 384-well NBS microplates (Corning). Resorufin epoxide substrate (20 uM stock in DMSO) was diluted to 5 μM with Assay Buffer (25 mM bis-Tris-HCl, pH 7.0, 1 mM DTT and 0.2 mg/ml BSA) and 8 microliters per well were added to the microplates. Thirty two microliters per well of 3.6 nM soluble epoxide hydrolase in Assay Buffer was then added. The samples were incubated at room temperature and assay signals were monitored by reading excitation at 530 nm and emission fluorescence at 590 nm on a PlateVision (Zeiss) reader every 2 minutes for 8 times.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886262";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3808903";"";"0";"288.44";"0";"3.89";"8d(R)";"C[C@@H](NC(=O)NCCCc1ccccc1)C1CCCCC1";"IC50";"'='";"302.0";"nM";"6.52";"";"";"UO_0000065";"22.60";"0.42";"2.63";"15.85";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL3808430";"";"0";"298.39";"0";"2.65";"8c(R)";"O=C(NCCCc1ccccc1)N[C@@H](CO)c1ccccc1";"IC50";"'='";"2740.0";"nM";"5.56";"";"";"UO_0000065";"18.64";"0.35";"2.91";"9.06";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL4097831";"";"0";"423.43";"0";"4.97";"1";"COc1ccc(CNC(=O)c2ccc(OC)c(OC3CCCC3)c2)c(C(F)(F)F)c1";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"21.78";"0.42";"4.25";"16.24";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4080506";"";"0";"400.44";"0";"3.61";"25";"CCC(C)C(=O)N1CCC(C(=O)NCc2ccc(OC)cc2C(F)(F)F)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"20.36";"0.40";"4.54";"13.91";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4127364";"";"0";"488.81";"1";"5.02";"6d";"S=C(NCCCCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"21.1";"nM";"7.68";"";"";"UO_0000065";"15.70";"0.32";"2.66";"15.95";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4129973";"";"0";"420.67";"1";"6.27";"4f";"S=C(Nc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)NC1C2CC3CC(C2)CC1C3";"IC50";"'='";"5936.0";"nM";"5.23";"";"";"UO_0000065";"12.42";"0.24";"-1.04";"21.72";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4128031";"";"0";"448.72";"1";"7.05";"3h";"CC(NC(=S)Nc1ccc(C23CC4CC(CC(C4)C2)C3)cc1)C12CC3CC(CC(C3)C1)C2";"IC50";"'='";"57393.0";"nM";"4.24";"";"";"UO_0000065";"9.45";"0.18";"-2.81";"17.63";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4128840";"";"0";"318.46";"0";"4.33";"1k";"Fc1cccc(NC(=S)NCC23CC4CC(CC(C4)C2)C3)c1";"IC50";"'='";"281.0";"nM";"6.55";"";"";"UO_0000065";"20.57";"0.41";"2.22";"27.23";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4216368";"";"0";"410.39";"0";"4.80";"18";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(O)cc2)CC1";"Ki";"'='";"9.1";"nM";"8.04";"";"";"UO_0000065";"19.59";"0.38";"3.24";"10.07";"False";"CHEMBL4187629";"Competitive inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using varying CMNPC substrate levels by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4218633";"";"0";"632.79";"1";"2.38";"4";"C[C@@H]1C[C@]23OCC(C)(O)[C@H]2O[C@@]2(O3)[C@H]1[C@@]1(C)CC[C@@]34C[C@@]35CC[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]2O";"Inhibition";"'='";"63.2";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4191389";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate at 100 uM measured for 1 hr by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4208985";"";"0";"660.85";"1";"3.61";"9";"CC(=O)OC(C)(C)[C@H]1O[C@@]23O[C@@H]1C[C@@H](C)[C@@H]2[C@@]1(C)CC[C@@]24C[C@@]25CC[C@H](O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]3O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4191391";"Competitive inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4208326";"";"0";"439.39";"0";"3.86";"13";"O=C(Nc1ccc(OC(F)(F)F)cc1)NN1CCC(Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"8.0";"nM";"8.10";"";"";"UO_0000065";"18.43";"0.36";"4.24";"8.09";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL3824213";"";"0";"445.30";"1";"5.61";"8c";"CCC(=O)Nc1cc(Cl)c(Oc2ccc(O)c(-c3ccc(C(N)=O)cc3)c2)c(Cl)c1";"IC50";"'='";"8600.0";"nM";"5.07";"";"";"UO_0000065";"11.38";"0.23";"-0.54";"4.98";"False";"CHEMBL3825936";"Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured after 10 mins by liquid scintillation counter method";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"BTI-TN-5B1-4";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3822419";"1";"Scientific Literature";"J. Med. Chem.";"2016";"CHEMBL3833782"
"CHEMBL3809988";"";"0";"332.45";"0";"4.83";"8f(R)";"C[C@@H](NC(=O)NCCCc1ccccc1)c1cccc2ccccc12";"IC50";"'='";"364.0";"nM";"6.44";"";"";"UO_0000065";"19.37";"0.35";"1.61";"15.65";"False";"CHEMBL3812611";"Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3808295";"1";"Scientific Literature";"Eur. J. Med. Chem.";"2016";"None"
"CHEMBL4212729";"";"0";"636.82";"2";"2.09";"7";"C[C@@H]1[C@H]2OC(C)(C)[C@@H](O)[C@@]2(O)O[C@H]2[C@H](O)[C@@]3(C)[C@@H]4CC[C@H]5C(C)(C)[C@@H](O[C@@H]6OC[C@@H](O)[C@H](O)[C@H]6O)CC[C@@]56C[C@@]46CC[C@]3(C)[C@@H]12";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4191391";"Competitive inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4204023";"";"0";"422.40";"0";"4.91";"15";"O=Cc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"4.0";"nM";"8.40";"";"";"UO_0000065";"19.88";"0.38";"3.49";"10.95";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4213817";"";"0";"480.48";"1";"5.66";"23";"CC(C)OC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"17.28";"0.33";"2.64";"9.66";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL1076184";"CIMIRACEMATE A";"0";"358.35";"0";"2.18";"2";"COc1ccc(/C=C/C(=O)OCC(=O)Cc2ccc(O)c(O)c2)cc1O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4010818";"Non-competitive inhibition of sEH (unknown origin) at 0.78 to 6.25 uM using PHOME as substrate measured for 30 mins by Lineweaver-burk plot method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4007474";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2017";"None"
"CHEMBL4279086";"";"0";"574.70";"2";"5.35";"10";"COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12";"IC50";"'='";"14.0";"nM";"7.85";"";"";"UO_0000065";"13.67";"0.26";"2.50";"6.63";"False";"CHEMBL4256769";"Inhibition of human sEH in human HepG2 cells using (+/-)14(15)-EET-d11 as substrate assessed as formation of (+/-)14(15)-DHET-d11 preincubated for 15 mins followed by substrate addition and measured after 10 mins by LC-MS/MS analysis";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"HepG2";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4094234";"";"0";"311.38";"0";"3.61";"18";"CC(C)(C)c1ccc(C(=O)NCc2ccc(C(=O)O)cc2)cc1";"IC50";"'='";"4200.0";"nM";"5.38";"";"";"UO_0000065";"17.27";"0.32";"1.77";"8.10";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4214103";"";"0";"459.48";"0";"4.41";"5b";"CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccc(F)cc2)cc1";"IC50";"'='";"0.96";"nM";"9.02";"";"";"UO_0000065";"19.63";"0.36";"4.61";"9.34";"False";"CHEMBL4190669";"Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate incubated for 5 mins followed by substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190176";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL4209184";"";"0";"475.93";"0";"4.92";"5c";"CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccc(Cl)cc2)cc1";"IC50";"'='";"0.48";"nM";"9.32";"";"";"UO_0000065";"19.58";"0.37";"4.40";"9.65";"False";"CHEMBL4190669";"Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate incubated for 5 mins followed by substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190176";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL4212613";"";"0";"471.51";"0";"4.28";"5e";"CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccc(OC)cc2)cc1";"IC50";"'='";"1.82";"nM";"8.74";"";"";"UO_0000065";"18.54";"0.34";"4.46";"8.26";"False";"CHEMBL4190669";"Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate incubated for 5 mins followed by substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190176";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL3764607";"";"0";"379.38";"0";"4.29";"15c";"CCC(Cc1cccc(C(=O)NCc2ccccc2C(F)(F)F)c1)C(=O)O";"IC50";"'='";"900.0";"nM";"6.05";"";"";"UO_0000065";"15.94";"0.31";"1.76";"9.11";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764948";"";"0";"393.41";"0";"4.68";"18c";"CCCC(Cc1ccc(C(=O)NCc2ccccc2C(F)(F)F)cc1)C(=O)O";"IC50";"'='";"5000.0";"nM";"5.30";"";"";"UO_0000065";"13.47";"0.26";"0.62";"7.98";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3765766";"";"0";"363.34";"0";"3.82";"22";"O=C(NCc1ccccc1C(F)(F)F)c1ccc(C2CC2C(=O)O)cc1";"IC50";"'='";"5500.0";"nM";"5.26";"";"";"UO_0000065";"14.48";"0.28";"1.44";"7.92";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL3764216";"";"0";"397.37";"0";"4.43";"13c";"CCC(Cc1ccc(C(=O)NCc2ccc(F)cc2C(F)(F)F)cc1)C(=O)O";"IC50";"'='";"1200.0";"nM";"5.92";"";"";"UO_0000065";"14.90";"0.29";"1.49";"8.92";"False";"CHEMBL3768766";"Inhibition of human recombinant sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3763124";"1";"Scientific Literature";"J. Med. Chem.";"2016";"None"
"CHEMBL4211405";"";"0";"424.42";"1";"5.11";"19";"COc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"20.08";"0.39";"3.41";"12.38";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4207039";"";"0";"437.42";"0";"4.20";"21";"NC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"19.89";"0.38";"4.50";"8.47";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4216368";"";"0";"410.39";"0";"4.80";"18";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(O)cc2)CC1";"TDI";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL4187627";"Time dependent inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction pre-incubated for 10 to 70 mins before CMNPC substrate addition by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4215208";"";"0";"528.53";"2";"6.45";"24";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)OCc3ccccc3)cc2)CC1";"TDI";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL4187627";"Time dependent inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction pre-incubated for 10 to 70 mins before CMNPC substrate addition by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL2397148";"";"0";"438.40";"0";"4.80";"t-TUCB";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"Km";"'>'";"200000.0";"nM";"";"";"";"UO_0000065";"";"";"";"";"False";"CHEMBL4187630";"Competitive inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction assessed as increase in substrate Km using varying CMNPC substrate levels by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4071919";"";"0";"378.39";"0";"4.41";"41";"CC(C)(C)c1ccc(C(=O)NCc2ccc(NC(=O)C(F)(F)F)cc2)cc1";"IC50";"'='";"660.0";"nM";"6.18";"";"";"UO_0000065";"16.33";"0.31";"1.77";"10.62";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4061980";"";"0";"360.48";"0";"3.29";"46";"CC(C)(C)c1ccc(C(=O)NCc2ccc(NS(C)(=O)=O)cc2)cc1";"IC50";"'='";"650.0";"nM";"6.19";"";"";"UO_0000065";"17.16";"0.34";"2.90";"8.22";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4073326";"";"0";"325.45";"0";"4.70";"49";"CC(C)Oc1ccc(CNC(=O)c2ccc(C(C)(C)C)cc2)cc1";"IC50";"";"";"";"";"";"Nd(Insoluble)";"";"";"";"";"";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4074393";"";"0";"367.44";"1";"5.53";"54";"CC(C)(C)c1ccc(C(=O)NCc2ccc(SC(F)(F)F)cc2)cc1";"IC50";"'='";"390.0";"nM";"6.41";"";"";"UO_0000065";"17.44";"0.35";"0.88";"22.02";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL1231797";"";"0";"344.20";"0";"3.75";"2b";"O=C(Nc1ccc(I)cc1)NC1CCCCC1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4019418";"Inhibition of sEH in primary human monocytes-derived macrophages assessed as reduction in LPS-stimulated IL-12p70 release at 10 uM after 16 hrs by cytometric bead array method";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL3322796";"";"0";"513.76";"2";"5.83";"BDBM50057419";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCC(=O)OCCOCCOCCO)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"423455";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3558235";"";"0";"455.60";"0";"3.59";"BDBM179755";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)O";"IC50";"'='";"392.0";"nM";"6.41";"";"423461";"UO_0000065";"14.06";"0.27";"2.82";"4.42";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322811";"";"0";"397.59";"0";"3.69";"BDBM179758";"CCCCCNC(=O)NCCCC/C=C\CCCCC[S+]([O-])c1ncn[nH]1";"IC50";"'='";"96.0";"nM";"7.02";"";"423471";"UO_0000065";"17.65";"0.35";"3.33";"7.03";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322813";"";"0";"405.63";"1";"5.63";"BDBM50057493";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCc1nnn[nH]1)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"423473";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322814";"";"0";"364.54";"0";"3.91";"BDBM50057494";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1nnn[nH]1";"IC50";"'='";"11.0";"nM";"7.96";"";"423489";"UO_0000065";"21.83";"0.42";"4.05";"8.33";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3927470";"";"0";"414.57";"0";"2.60";"BDBM179761";"CCCCNC(=O)C(=O)NCCCC/C=C\CCCCCCC1=NOS(=O)N1";"IC50";"'>'";"500.0";"nM";"";"";"423481";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3895613";"";"0";"451.44";"0";"4.46";"BDBM158485";"CNC(=O)c1ccc(OC2CCC(NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"301041";"UO_0000065";"20.60";"0.40";"4.84";"10.49";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322810";"";"0";"381.59";"0";"4.67";"BDBM50057481";"CCCCCNC(=O)NCCCC/C=C\CCCCCSc1ncn[nH]1";"IC50";"'='";"32.0";"nM";"7.50";"";"423470";"UO_0000065";"19.64";"0.39";"2.82";"9.06";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL566315";"OBETICHOLIC ACID";"4";"420.63";"1";"5.11";"1a; OCA; 6alpha-ethyl-CDCA";"CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O";"Inhibition";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL4019485";"Inhibition of sEH in human HuT-78 cells assessed as reduction in Pam3CSK4-stimulated TNFalpha release preincubated for 24 hrs followed by Pam3CSK4 addition measured after 18 hrs by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4073578";"";"0";"416.44";"0";"3.98";"21";"COc1ccc(CNC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)c(C(F)(F)F)c1";"IC50";"'='";"1.7";"nM";"8.77";"";"";"UO_0000065";"21.06";"0.41";"4.79";"12.92";"False";"CHEMBL4049250";"Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4043306";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4128873";"";"0";"516.87";"2";"5.80";"6f";"S=C(NCCCCCCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"7.2";"nM";"8.14";"";"";"UO_0000065";"15.75";"0.32";"2.34";"16.92";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4127510";"";"0";"474.78";"0";"4.63";"6c";"S=C(NCCCCNC(=S)NC12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"90.8";"nM";"7.04";"";"";"UO_0000065";"14.83";"0.30";"2.41";"14.63";"False";"CHEMBL4124027";"Inhibition of recombinant human sEH expressed in baculovirus expression system using CMNPC as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by fluorescent based assay";"B";"BAO_0000019";"assay format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4118216";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4203677";"";"0";"660.85";"1";"3.61";"1";"CC(=O)O[C@H]1[C@H](O[C@H]2CC[C@]34C[C@]35CC[C@]3(C)[C@H]6[C@H](C)C[C@H]7O[C@@]6(O[C@H]7C(C)(C)O)[C@H](O)[C@@]3(C)C5=CC[C@H]4C2(C)C)OC[C@@H](O)[C@@H]1O";"Inhibition";"'='";"64.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4191389";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate at 100 uM measured for 1 hr by fluorescence assay relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4203223";"";"0";"424.42";"0";"4.59";"16";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(CO)cc2)CC1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"20.08";"0.39";"3.93";"10.68";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4209593";"";"0";"509.48";"1";"4.00";"28";"COC(=O)CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"3.0";"nM";"8.52";"";"";"UO_0000065";"16.73";"0.32";"4.52";"7.41";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4214503";"";"0";"527.54";"2";"6.03";"29";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)NCc3ccccc3)cc2)CC1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"15.74";"0.30";"2.27";"9.36";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL3322800";"";"0";"425.61";"0";"4.43";"BDBM50057423";"CCCCCN(C)C(=O)N(C)CCCC/C=C\CCCCCCC(=O)NCC(=O)O";"IC50";"'>'";"500.0";"nM";"";"";"423460";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322802";"";"0";"479.69";"1";"5.05";"BDBM50057445";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)NS(=O)(=O)c1ccccc1";"IC50";"'='";"41.0";"nM";"7.39";"";"423462";"UO_0000065";"15.40";"0.31";"2.34";"7.08";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL3322826";"";"0";"406.55";"0";"4.29";"BDBM50057638";"CCCCCNC(=O)NCCCCCOc1cccc2sc(NC(C)=O)nc12";"IC50";"'>'";"500.0";"nM";"";"";"423485";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL497001";"ALOIN";"0";"418.40";"1";"-0.89";"2";"O=C1c2c(O)cccc2C([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c2cc(CO)cc(O)c21";"Inhibition";"'='";"73.9";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL3620668";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde at 100 uM measured during 1 hr by fluorescence photometric analysis relative to control";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL3901070";"";"0";"469.89";"1";"5.23";"BDBM158487";"CNC(=O)c1ccc(OC2CCC(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)cc1";"IC50";"'='";"0.5";"nM";"9.30";"";"301042";"UO_0000065";"19.79";"0.40";"4.07";"11.71";"False";"CHEMBL3705981";"sEH Assay: See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3638864";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4066332";"";"0";"394.92";"0";"3.94";"57";"CC(C)(C)c1ccc(C(=O)NCc2ccc(NS(C)(=O)=O)cc2Cl)cc1";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4019485";"Inhibition of sEH in human HuT-78 cells assessed as reduction in Pam3CSK4-stimulated TNFalpha release preincubated for 24 hrs followed by Pam3CSK4 addition measured after 18 hrs by ELISA";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4203677";"";"0";"660.85";"1";"3.61";"1";"CC(=O)O[C@H]1[C@H](O[C@H]2CC[C@]34C[C@]35CC[C@]3(C)[C@H]6[C@H](C)C[C@H]7O[C@@]6(O[C@H]7C(C)(C)O)[C@H](O)[C@@]3(C)C5=CC[C@H]4C2(C)C)OC[C@@H](O)[C@@H]1O";"IC50";"'='";"60900.0";"nM";"4.21";"";"";"UO_0000065";"6.38";"0.12";"0.61";"2.92";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4211861";"";"0";"632.84";"1";"3.70";"2";"COC(C)(C)[C@H]1O[C@@]23O[C@@H]1C[C@@H](C)[C@@H]2[C@@]1(C)CC[C@@]24C[C@@]25CC[C@H](O[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]3O";"IC50";"'='";"400.0";"nM";"6.40";"";"";"UO_0000065";"10.11";"0.19";"2.70";"5.03";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4290919";"";"0";"609.15";"2";"6.00";"6";"COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12";"IC50";"'='";"680.0";"nM";"6.17";"";"";"UO_0000065";"10.12";"0.20";"0.17";"5.20";"False";"CHEMBL4256761";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by spectrofluorimetry";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL431348";"";"0";"574.70";"2";"5.27";"2";"COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12";"IC50";"'='";"590.0";"nM";"6.23";"";"";"UO_0000065";"10.84";"0.21";"0.96";"5.26";"False";"CHEMBL4256761";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by spectrofluorimetry";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL3322819";"";"0";"441.68";"1";"5.77";"BDBM50057630";"CCCCCCC(=O)N(CCCC/C=C\CCCCCCC1=NOS(=O)N1)C(C)C";"IC50";"'>'";"500.0";"nM";"";"";"423480";"UO_0000065";"";"";"";"";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL4109511";"";"0";"455.60";"0";"3.59";"BDBM64550";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)N[C@H](CC(=O)O)C(=O)O";"IC50";"'='";"392.0";"nM";"6.41";"";"423490";"UO_0000065";"14.06";"0.27";"2.82";"4.42";"False";"CHEMBL3888931";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886890";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL215387";"";"0";"392.58";"1";"5.24";"AUDA";"O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2";"IC50";"'='";"0.6";"nM";"9.22";"";"";"UO_0000065";"23.49";"0.45";"3.98";"11.76";"False";"CHEMBL4269821";"Inhibition of soluble epoxide hydrolase (unknown origin) using NEPC as substrate after 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4266023";"1";"Scientific Literature";"J Nat Prod";"2018";"None"
"CHEMBL4217562";"";"0";"455.51";"0";"4.58";"5d";"CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccc(C)cc2)cc1";"IC50";"'='";"0.48";"nM";"9.32";"";"";"UO_0000065";"20.46";"0.37";"4.74";"9.65";"False";"CHEMBL4190669";"Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate incubated for 5 mins followed by substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190176";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL2397148";"";"0";"438.40";"0";"4.80";"t-TUCB";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"TDI";"";"";"";"";"";"Not Active";"";"";"";"";"";"False";"CHEMBL4187627";"Time dependent inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction pre-incubated for 10 to 70 mins before CMNPC substrate addition by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL3617997";"";"0";"534.51";"3";"-1.40";"6, aloinoside C";"C[C@@H]1O[C@@H](OCc2cc(O)c3c(c2)[C@H]([C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)c2cccc(O)c2C3=O)[C@H](O)[C@H](O)[C@H]1O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3620672";"Non-competitive inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL40275";"ALOE-EMODIN";"0";"270.24";"0";"1.37";"1";"O=C1c2cccc(O)c2C(=O)c2c(O)cc(CO)cc21";"IC50";"'='";"26800.0";"nM";"4.57";"";"";"UO_0000065";"16.92";"0.31";"3.20";"4.82";"False";"CHEMBL3620669";"Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL40275";"ALOE-EMODIN";"0";"270.24";"0";"1.37";"1";"O=C1c2cccc(O)c2C(=O)c2c(O)cc(CO)cc21";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL3620672";"Non-competitive inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 30 mins by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3616406";"1";"Scientific Literature";"Bioorg. Med. Chem.";"2015";"None"
"CHEMBL1257635";"";"0";"395.40";"0";"2.52";"BDBM50327848";"CCS(=O)(=O)N1CCC(NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1";"IC50";"'='";"0.4";"nM";"9.40";"";"377053";"UO_0000065";"23.77";"0.49";"6.88";"10.71";"False";"CHEMBL3888169";"Fluorescent Based Assay: IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-(3-phenyl-oxyran-2-yl)methyl carbonate (CMNPC) was used as the fluorescent substrate. Human sEH (1 nM) or murine sEH (1 nM) was incubated with the inhibitor for 5 min in pH 7.0 Bis-Tris/HCl buffer (25 mM) containing 0.1 mg/mL of BSA at 30° C. prior to substrate introduction ([S]=5 μM). Activity was determined by monitoring the appearance of 6-methoxy-2-naphthaldehyde over 10 minutes by fluorescence detection with an excitation wavelength of 330 nm and an emission wavelength of 465 nm.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886192";"37";"BindingDB Database";"";"2016";"None"
"CHEMBL2397138";"";"0";"451.45";"0";"4.46";"25";"CNC(=O)c1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"2.0";"nM";"8.70";"";"";"UO_0000065";"19.27";"0.37";"4.24";"9.81";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL2397148";"";"0";"438.40";"0";"4.80";"t-TUCB";"O=C(Nc1ccc(OC(F)(F)F)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"Ki";"'='";"156.0";"nM";"6.81";"";"";"UO_0000065";"15.53";"0.30";"2.01";"7.03";"False";"CHEMBL4187629";"Competitive inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using varying CMNPC substrate levels by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4289768";"";"0";"592.69";"2";"5.49";"9";"COc1cc(C(=O)NS(=O)(=O)c2cccc(F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12";"IC50";"'='";"410.0";"nM";"6.39";"";"";"UO_0000065";"10.78";"0.21";"0.90";"5.39";"False";"CHEMBL4256761";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by spectrofluorimetry";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL4212165";"";"0";"388.85";"0";"4.55";"4";"O=C(Nc1ccc(Cl)cc1)N[C@H]1CC[C@H](Oc2ccc(C(=O)O)cc2)CC1";"IC50";"'='";"7.0";"nM";"8.15";"";"";"UO_0000065";"20.97";"0.41";"3.60";"9.30";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4111533";"";"0";"558.45";"None";"None";"BDBM179752";"";"IC50";"'>'";"500.0";"nM";"";"";"326374";"UO_0000065";"";"";"";"";"False";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322797";"";"0";"472.67";"0";"4.11";"BDBM50057420";"CCCCCNC(=O)NCCCC/C=C\CCCCCCC(=O)OCCOCCOCCO";"IC50";"'='";"255.0";"nM";"6.59";"";"326375";"UO_0000065";"13.95";"0.27";"2.48";"6.21";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322811";"";"0";"397.59";"0";"3.69";"BDBM179758";"CCCCCNC(=O)NCCCC/C=C\CCCCC[S+]([O-])c1ncn[nH]1";"IC50";"'='";"96.0";"nM";"7.02";"";"326390";"UO_0000065";"17.65";"0.35";"3.33";"7.03";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL3322817";"";"0";"380.53";"0";"4.07";"BDBM50057506";"CCCCCNC(=O)NCCCC/C=C\CCCCCCc1noc(=O)[nH]1";"IC50";"'='";"65.0";"nM";"7.19";"";"326396";"UO_0000065";"18.89";"0.36";"3.12";"7.19";"True";"CHEMBL3887243";"Inhibition Assay: Compounds were tested for their ability to inhibit recombinant soluble epoxide hydrolase (sEH) protein. The assay utilizes (3-Phhenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphthalen-2-yl)-methyl ester (PHOME), a sensitive substrate for sEH that can be used to monitor the activity of both human and murine enzymes. Hydrolysis of the substrate epoxide yields a highly fluorescent product, 6-methoxy-2-Naphthaldehyde, which can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. See Wolf et al., Anal Biochem 355:71-80, 2006 PMID: 16729954. Human recombinant sEH was incubated with substrate and compounds ranging in concentration from 0.1 to 1000 nM.";"B";"BAO_0000357";"single protein format";"None";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL3886235";"37";"BindingDB Database";"";"2015";"None"
"CHEMBL4091019";"";"0";"295.38";"0";"3.73";"34";"CC(C)(C)c1ccc(C(=O)NCc2ccc(C=O)cc2)cc1";"IC50";"'='";"510.0";"nM";"6.29";"";"";"UO_0000065";"21.30";"0.39";"2.56";"13.63";"False";"CHEMBL4019416";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4104364";"";"0";"305.33";"0";"3.47";"17";"O=C(O)c1ccc(CNC(=O)c2ccc3ccccc3c2)cc1";"Inhibition";"'='";"45.0";"%";"";"";"";"UO_0000187";"";"";"";"";"False";"CHEMBL4019417";"Inhibition of recombinant human sEH at 50 uM using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence photometric method";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4017509";"1";"Scientific Literature";"J Med Chem";"2017";"None"
"CHEMBL4288574";"";"0";"588.73";"2";"5.66";"3";"COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12";"IC50";"'='";"150.0";"nM";"6.82";"";"";"UO_0000065";"11.59";"0.22";"1.16";"5.76";"False";"CHEMBL4256761";"Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by spectrofluorimetry";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4251751";"1";"Scientific Literature";"J Med Chem";"2018";"None"
"CHEMBL3677989";"";"0";"419.40";"0";"4.97";"14";"N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)cc1";"IC50";"'='";"5.0";"nM";"8.30";"";"";"UO_0000065";"19.79";"0.38";"3.33";"9.96";"False";"CHEMBL4187625";"Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluorescence based assay";"B";"BAO_0000219";"cell-based format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4184221";"1";"Scientific Literature";"Bioorg Med Chem Lett";"2018";"None"
"CHEMBL4204107";"";"0";"576.73";"2";"1.45";"8";"C[C@@H]1CC(=O)[C@H](O)[C@]2(O)[C@H]1[C@@]1(C)CC[C@@]34C[C@@]35CC[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)C(C)(C)[C@@H]5CC=C4[C@]1(C)[C@H]2O";"IC50";"'='";"8600.0";"nM";"5.07";"";"";"UO_0000065";"8.78";"0.17";"3.62";"3.23";"False";"CHEMBL4191390";"Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4207574";"";"0";"678.86";"3";"2.41";"29";"CC(=O)O[C@H](C[C@@H](C)[C@H]1C(=O)[C@H](O)[C@@]2(C)C3=CC[C@H]4C(C)(C)[C@@H](O[C@@H]5OC[C@@H](O)[C@H](O)[C@H]5O)CC[C@@]45C[C@@]35CC[C@]12C)[C@@H](O)C(C)(C)O";"Inhibition";"";"";"";"";"";"Active";"";"";"";"";"";"False";"CHEMBL4191393";"Non-competitive inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by Lineweaver-Burk plot analysis";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190200";"1";"Scientific Literature";"J Nat Prod";"2017";"None"
"CHEMBL4203740";"";"0";"485.50";"0";"3.97";"3";"CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccccc2C(=O)O)cc1";"IC50";"'='";"1.92";"nM";"8.72";"";"";"UO_0000065";"17.95";"0.33";"4.75";"6.51";"False";"CHEMBL4190669";"Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate incubated for 5 mins followed by substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190176";"1";"Scientific Literature";"MedChemComm";"2016";"None"
"CHEMBL4204830";"";"0";"441.49";"0";"4.27";"5a";"CCOC(=O)C1=C(c2ccccc2)NC(=O)NC1c1ccc(NC(=O)c2ccccc2)cc1";"IC50";"'='";"1.22";"nM";"8.91";"";"";"UO_0000065";"20.19";"0.37";"4.64";"9.23";"False";"CHEMBL4190669";"Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate incubated for 5 mins followed by substrate addition by fluorescence assay";"B";"BAO_0000357";"single protein format";"Homo sapiens";"None";"None";"None";"None";"CHEMBL2409";"Epoxide hydratase";"Homo sapiens";"SINGLE PROTEIN";"CHEMBL4190176";"1";"Scientific Literature";"MedChemComm";"2016";"None"
