Artificial Intelligence Prediction Across 12,000 Samples Shows Widespread Increased Gene-Gene Chromatin Interactions in Cancers that Constitute Therapeutic Vulnerabilities

Dao Fuying

Keywords: 3D Genomics, Artificial Intelligence, Epigenetics, Gene-Gene Interaction, Drug Screening, Cancer Therapy

TL;DR: AI4Loop leverages deep learning on RNA-Seq data to predict gene-gene chromatin interactions, revealing oncogenic GGIs across cancers and identifying drug candidates that disrupt these interactions for potential therapeutic repurposing.

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Submission Number: 68