Genome-wide analysis reveals extensive genetic overlap between childhood phenotypes and later-life type 2 diabetes

Shizheng Qiu, Yige Sun, Jiahe Guo, Yu Zhang, Yang Hu

Abstract: Highlights•Childhood obesity, BMI, and SBP show significant genetic correlations with later-life T2D.•Mediation analysis identifies potential mediators, such as extreme BMI, hip circumference, and waist circumference, influencing the link between childhood obesity and T2D..•Shared genetic loci between childhood obesity, BMI, SBP, and T2D provide novel insights into the shared genetic architecture.