Advancing Kitome Analysis in Low Abundance Sterility Testing: Blinded Microbial Study Through the Lens of Deep Learning and Nanopore Sequencing

James P. B. Strutt, Meenubharathi Natarajan, Charles Swofford, Rohan B. H. Williams, Stacy L. Springs, Suiyuan Xia

Keywords: Kit-ome, Deep Learning, Nanopore Sequencing, Blinded Studies, Sterility Testing, Cell Therapy Manufacturing

TL;DR: Our deep learning/nanopore approach distinguishes microbial contaminants from kit-ome artifacts in sterility testing with 87.9% accuracy. qPCR validation will confirm clinical applications.

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Submission Number: 187