ODORactor: a web server for deciphering olfactory coding

Xinyi Liu, Xubo Su, Fei Wang, Zhimin Huang, Qi Wang, Zhen Li, Ruina Zhang, Lifang Wu, Yi Pan, Yingyi Chen, Hanyi Zhuang, Guoqiang Chen, Ting Shi, Jian Zhang

Abstract: Summary: ODORactor is an open access web server aimed at providing a platform for identifying odorant receptors (ORs) for small molecules and for browsing existing OR-ligand pairs. It enables the prediction of ORs from the molecular structures of arbitrary chemicals by integrating two individual functionalities: odorant verification and OR recognition. The prediction of the ORs for several odorants was experimentally validated in the study. In addition, ODORactor features a comprehensive repertoire of olfactory information that has been manually curated from literature. Therefore, ODORactor may provide an effective way to decipher olfactory coding and could be a useful server tool for both basic olfaction research in academia and for odorant discovery in industry.