TTT-UNet: Enhancing U-Net with Test-Time Training Layers for Biomedical Image Segmentation

Rong Zhou, Zhengqing Yuan, Zhiling Yan, Weixiang Sun, Kai Zhang, Yiwei Li, Yanfang Ye, Xiang Li, Lichao Sun, Lifang He

Keywords: Biomedical Image Segmentation, U-Net, Test-Time Training

Abstract: Biomedical image segmentation is crucial for accurately diagnosing and analyzing various diseases. However, Convolutional Neural Networks (CNNs) and Transformers, the most commonly used architectures for this task, struggle to effectively capture long-range dependencies due to the inherent locality of CNNs and the computational complexity of Transformers. To address this limitation, we introduce TTT-UNet, a novel framework that integrates Test-Time Training (TTT) layers into the traditional U-Net architecture for biomedical image segmentation. TTT-UNet dynamically adjusts model parameters during the test time, enhancing the model's ability to capture both local and long-range features. We evaluate TTT-UNet on multiple medical imaging datasets, including 3D abdominal organ segmentation in CT and MR images, instrument segmentation in endoscopy images, and cell segmentation in microscopy images. The results demonstrate that TTT-UNet consistently outperforms state-of-the-art CNN-based and Transformer-based segmentation models across all tasks. The code is available at https://github.com/rongzhou7/TTT-UNet.

Primary Subject Area: Segmentation

Secondary Subject Area: Unsupervised Learning and Representation Learning

Registration Requirement: Yes

Reproducibility: https://github.com/rongzhou7/TTT-UNet

Visa & Travel: Yes

Read CFP & Author Instructions: Yes

Originality Policy: Yes

Single-blind & Not Under Review Elsewhere: Yes

LLM Policy: Yes

Submission Number: 342