PPII-AEAT: Prediction of protein-protein interaction inhibitors based on autoencoders with adversarial training

Zitong Zhang, Lingling Zhao, Mengyao Gao, Yuanlong Chen, Junjie Wang, Chunyu Wang

Abstract: Highlights•A novel deep learning-based PPI inhibitor prediction method called PPII-AEAT.•Adaptively learning molecular representations via an autoencoder architecture.•Adversarial training improves the robustness and generalization of the model.•Experimental results verify the effectiveness of PPII-AEAT.