FluoGen: An Open-Source Generative Foundation Model for Fluorescence Microscopy Image Enhancement and Analysis

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Huaian Chen, Shiyao Hong, Yuxuan Gu, Junkang Dai, Zhixiang Wei, Liyang He, Bo Xu, Yi Jin, Enhong Chen

Published: 14 Jan 2026, Last Modified: 23 Jan 2026CrossrefEveryoneRevisionsCC BY-SA 4.0
Abstract: Fluorescence microscopy, empowered by artificial intelligence (AI), has shown great promise in advancing life science. However, the high cost and complexity of sample preparation limit the availability of training data, constraining the performance of AI-based models. Here, we present FluoGen,...