High-Throughput Protein Perturbation Screens with AI-Designed Degraders

Lin Zhao, Aastha Pal, Tong Chen, Pranam Chatterjee

Published: 23 Sept 2025, Last Modified: 26 Sept 2025AI4D3 2025 PosterEveryoneRevisionsBibTeXCC BY 4.0
Keywords: AI-designed peptides, protein perturbation, ubiquibodies, deubiquibodies, targeted protein degradation, high-throughput screening, Perturb-Seq, proteome editing
TL;DR: We present a high-throughput, CRISPR-like screening platform that enables functional evaluation of AI-designed peptides for programmable proteome perturbation.
Submission Number: 12