Abstract: Highlights•Outlines the setup of challenge on “Retinal Image Analysis for multi-Disease Detection” held at ISBI-2021.•Describes the creation of RFMiD dataset, evaluation criteria and results of top-performing participating solutions.•Presents various deep learning-based top-performing participating approaches.•Discusses the influence of rare pathologies on multi-disease classification performance from analysis of the methods submitted to this challenge.
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