The Illustrated AlphaFold

Elana Simon, Jake Silberg

Blogpost Url: https://d2jud02ci9yv69.cloudfront.net/2025-04-28-the-illustrated-alphafold-55/blog/the-illustrated-alphafold/

Abstract: We present the Illustrated AlphaFold, a visual walkthrough of the architecture and information flow of AlphaFold 3. We explain every model component and training detail, with particular focus on the advances since AlphaFold 2 – including the unified tokenization scheme that extends to DNA, RNA, and small molecules, as well as the novel diffusion-based structural module. Finally, we include some musings on the ML lessons learned from studying AlphaFold 3.

Conflict Of Interest: n/a

Submission Number: 30