Hierarchically-coupled hidden Markov models for learning kinetic rates from single-molecule data

Jan-Willem van de Meent, Jonathan E. Bronson, Frank D. Wood, Ruben L. Gonzalez, Chris Wiggins

Abstract: We address the problem of analyzing sets of noisy time-varying signals that all report on the same process but confound straightforward analyses due to complex inter-signal heterogeneities and meas...