Unpaired volumetric harmonization of brain MRI with conditional latent diffusion

Mengqi Wu, Minhui Yu, Shuaiming Jing, Pew-Thian Yap, Zhengwu Zhang, Mingxia Liu

Abstract: Highlights•HCLD performs 3D volumetric harmonization for brain MRIs.•HCLD harmonizes multi-site MRI data without requiring paired traveling subjects.•Two-stage training improves generalizability and reduces computational cost.•Effectively removes site/scanner variations while preserving biological information.•Separate content and style losses enhance image quality and anatomical fidelity.

External IDs:doi:10.1016/j.media.2025.103849