Graph convolution network based on meta-paths and mutual information for drug-target interaction prediction

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Shujuan Cao, Binying Cai, Zhejian Qiu, Tiantian Chang, Qiqige Wuyun, Fang-Xiang Wu

Published: 2025, Last Modified: 27 Feb 2026BMC Bioinform. 2025EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Predicting drug-target interactions (DTIs) plays a pivotal role in accelerating drug repositioning by prioritizing candidate drugs and reducing experimental costs. Despite advancements in deep learning, several challenges still require further exploration, including sparsity and inadequate representation of feature relationships.