Alz-QNet: A quantum regression network for studying Alzheimer’s gene interactions

Debanjan Konar, Neerav Sreekumar, Richard Jiang, Vaneet Aggarwal

Abstract: Highlights•Our quantum regression model reveals key gene interactions in Alzheimer’s brain tissue.•The proposed Alz-QNet halves quantum gate cost to model gene networks more efficiently.•Single-nucleus RNA-seq data used to decode Alzheimer’s gene regulation.•Identifies PLD3, APP, and YY1 as targets for Alzheimer’s gene therapies.•Quantum regression uncovers feedback loops in entorhinal cortex gene activity.

External IDs:doi:10.1016/j.compbiomed.2025.110837