Unpaired translation of chest X-ray images for lung opacity diagnosis via adaptive activation masks and cross-domain alignment

Junzhi Ning, Dominic C. Marshall, Yijian Gao, Xiaodan Xing, Yang Nan, Yingying Fang, Sheng Zhang, Matthieu Komorowski, Guang Yang

Abstract: Highlights•Unpaired translation removes lung opacities yet keeps key features in X-rays.•Adaptive masks highlight and constrain opacity changes for better interpretability.•Cross-domain alignment reduces artefacts and preserves real diagnostic features.•Experiments show improved image fidelity, segmentation, and lesion classification.