Homogenization of word relationships in schizophrenia: Topological analysis of cortical semantic representations

Ryusuke Hayashi, Shizuo Kaji, Yukiko Matsumoto, Satoshi Nishida, Shinji Nishimoto, Hidehiko Takahashi

Abstract: Patients with schizophrenia typically exhibit symptoms of disorganized thought and display concreteness and over-inclusion in verbal reports, depending on the level of abstraction. While concreteness and over-inclusion may appear contradictory, the underlying psychopathology that explains these symptoms remains unclear. In the current study, we used functional magnetic resonance imaging with an encoding modeling approach to examine how concepts of various words, represented as brain activity, are anomalously connected at different levels of abstraction in patients with schizophrenia.

External IDs:doi:10.1111/pcn.13727