A Severity Score for Retinopathy of Prematurity

Peng Tian, Yuan Guo, Jayashree Kalpathy-Cramer, Susan Ostmo, John Peter Campbell, Michael F. Chiang, Jennifer G. Dy, Deniz Erdogmus, Stratis Ioannidis

Abstract: Retinopathy of Prematurity (ROP) is a leading cause for childhood blindness worldwide. An automated ROP detection system could significantly improve the chance of a child receiving proper diagnosis and treatment. We propose a means of producing a continuous severity score in an automated fashion, regressed from both (a) diagnostic class labels as well as (b) comparison outcomes. Our generative model combines the two sources, and successfully addresses inherent variability in diagnostic outcomes. In particular, our method exhibits an excellent predictive performance of both diagnostic and comparison outcomes over a broad array of metrics, including AUC, precision, and recall.