Dual regression physiological modeling of resting-state EPI power spectra: Effects of healthy aging

Olivia Viessmann, Harald E. Möller, Peter Jezzard

Abstract: Highlights•We present a dual regression method to model power spectra of ultra-fast EPI data to map and quantify physiological contributions.•The method was used to study cardiac and respiratory contributions to the EPI data in healthy aging.•We found a significant increase in the spatial extent of cardiac modulated voxels in white matter with age.•The strength of cardiac-related EPI power did not show an age effect.