Multi-pathology MRI lesion segmentation in a multi-centre cohort of patients with focal epilepsy: a MELD study

Mathilde Ripart, MELD consortium, Sophie Adler, Konrad Wagstyl

Keywords: lesion detection, nnU-Net, MRI, epilepsy, multi-centre

Abstract: Drug-resistant focal epilepsy can be caused by structural lesions for which surgery can be curative if the lesion is found and fully resected. We built a large multi-centre MRI dataset of 1181 patients with focal epilepsy and 1009 healthy controls to train a state-of-the-art nnU-Net model to segment a range of aetiologies on T1w MRI scans. The model was able to detect different aetiological causes of focal epilepsy with a sensitivity of 73\% in patients and a specificity of 90\% in controls.

Submission Number: 42