scKINETICS: inference of regulatory velocity with single-cell transcriptomics data

Cassandra Burdziak, Chujun Julia Zhao, Doron Haviv, Direna Alonso-Curbelo, Scott W. Lowe, Dana Pe'er

Abstract: Transcriptional dynamics are governed by the action of regulatory proteins and are fundamental to systems ranging from normal development to disease. RNA velocity methods for tracking phenotypic dynamics ignore information on the regulatory drivers of gene expression variability through time.