Positional encoding-guided transformer-based multiple instance learning for histopathology whole slide images classification

Jun Shi, Dongdong Sun, Kun Wu, Zhiguo Jiang, Xue Kong, Wei Wang, Haibo Wu, Yushan Zheng

Abstract: Highlights•A novel histopathology WSI classification named PEGTB-MIL is proposed.•A position encoding module is designed to generate the spatial-aware embeddings.•A mask-based position reconstruction task is devised to guide positional learning.•PEGTB-MIL shows promise in predicting EGFR and GIST mutations from pathology WSIs.