Stain-adaptive self-supervised learning for histopathology image analysis

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Haili Ye, Yuan-yuan Yang, Shunzhi Zhu, Da-Han Wang, Xu-Yao Zhang, Xin Yang, Heguang Huang

Published: 01 Jan 2025, Last Modified: 19 Sept 2025Pattern Recognit. 2025EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Highlights•We propose SASSL: a novel stain-adaptive self-supervised learning method.•SASSL integrates stain domain adversarial training into the SSL framework.•SASSL adapts to stain variations while learning invariant tissue features.•Experiments show SASSL improves histopathology analysis across multiple tasks.