Standardized low-resolution brain electromagnetic tomography does not improve EEG Alzheimer's disease assessment

Wolfgang Fruehwirt, Martin Mairhofer, Andreas Hahn, Heinrich Garn, Markus Waser, Reinhold Schmidt, Thomas Benke, Peter Dal-Bianco, Gerhard Ransmayr, Dieter Grossegger, Stephen J. Roberts, Georg Dorffner

Abstract: Highlights•First study, in any disease, to examine the added value of a 3D source localization method.•Largest prospective multi-center AD study comparing markers of slowing, complexity, and functional connectivity.•Thousands of QEEG markers analyzed with stringent control for multiple testing.•Highly significant associations between QEEG markers and MMSE scores.•No additional benefit of sLORETA over surface QEEG for AD assessment.