ALE: a generic assembly likelihood evaluation framework for assessing the accuracy of genome and metagenome assemblies

Scott C. Clark, Rob Egan, Peter I. Frazier, Zhong Wang

Abstract: Researchers need general purpose methods for objectively evaluating the accuracy of single and metagenome assemblies and for automatically detecting any errors they may contain. Current methods do not fully meet this need because they require a reference, only consider one of the many aspects of assembly quality or lack statistical justification, and none are designed to evaluate metagenome assemblies.