LDpred2: better, faster, stronger

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Florian Privé, Julyan Arbel, Bjarni J. Vilhjálmsson

Published: 01 Jan 2021, Last Modified: 02 Oct 2024Bioinform. 2021EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Polygenic scores have become a central tool in human genetics research. LDpred is a popular method for deriving polygenic scores based on summary statistics and a matrix of correlation between genetic variants. However, LDpred has limitations that may reduce its predictive performance.