A strategy based on integer programming for optimal dosing and timing of preventive hypoglycemic treatments in type 1 diabetes management

Jacopo Pavan, Giulia Noaro, Andrea Facchinetti, Domenico Salvagnin, Giovanni Sparacino, Simone Del Favero

Abstract: Highlights•Hypoglycemia is a life-threatening condition for people with Type 1 Diabetes.•Fast acting carbohydrates can prevent hypoglycemia when consumed in time.•This algorithm optimizes carbohydrates intake suggestions to mitigate hypoglycemia.•Integer programming enables to quantize the suggestions and reduce patient burden.•In silico, the algorithm performed better than state-of-the-art comparators.