Single‐microglia transcriptomic transition network‐based prediction and real‐world patient data validation identifies ketorolac as a repurposable drug for Alzheimer's disease

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Jielin Xu, Wenqiang Song, Zhenxing Xu, Michael M. Danziger, Ehud Karavani, Chengxi Zang, Xin Chen, Yichen Li, Isabela M Rivera Paz, Dhruv Gohel, Chang Su, Yadi Zhou, Yuan Hou, Yishai Shimoni, Andrew A. Pieper, Jianying Hu, Fei Wang, Michal Rosen‐Zvi, James B. Leverenz, Jeffrey Cummings et al. (1 additional authors not shown)

Published: 01 Jan 2025, Last Modified: 24 Nov 2025Alzheimer's & DementiaEveryoneRevisionsCC BY-SA 4.0
Abstract: High microglial heterogeneities hinder the development of microglia-targeted treatment for Alzheimer's disease (AD).