MMDG-DTI: Drug-target interaction prediction via multimodal feature fusion and domain generalization

Yang Hua, Zhenhua Feng, Xiaoning Song, Xiaojun Wu, Josef Kittler

Abstract: Highlights•A large-language-model-based textual feature extractor for DTI representation.•A hybrid-GNN-based structural feature extractor augments topological features.•An innovative classifier mitigates the overfitting issue by domain generalization.•Novel cross-domain experiments evaluate the generalization capability of DTI methods.