Reconciling differential gene expression data with molecular interaction networks

Christopher L. Poirel, Ahsanur Rahman, Richard R. Rodrigues, Arjun Krishnan, Jacqueline R. Addesa, T. M. Murali

Abstract: Many techniques have been developed to compute the response network of a cell. A recent trend in this area is to compute response networks of small size, with the rationale that only part of a pathway is often changed by disease and that interpreting small subnetworks is easier than interpreting larger ones. However, these methods may not uncover the spectrum of pathways perturbed in a particular experiment or disease.