Accurate and adaptive imputation of summary statistics in mixed-ethnicity cohorts.

Matteo Togninalli, Damian Roqueiro, COPDGene Investigators, Karsten M. Borgwardt

Abstract: Methods based on summary statistics obtained from genome-wide association studies have gained considerable interest in genetics due to the computational cost and privacy advantages they present. Imputing missing summary statistics has therefore become a key procedure in many bioinformatics pipelines, but available solutions may rely on additional knowledge about the populations used in the original study and, as a result, may not always ensure feasibility or high accuracy of the imputation procedure.