MTTFsite: cross-cell type TF binding site prediction by using multi-task learning

Jiyun Zhou, Qin Lu, Lin Gui, Ruifeng Xu, Yunfei Long, Hongpeng Wang

Abstract: The prediction of transcription factor binding sites (TFBSs) is crucial for gene expression analysis. Supervised learning approaches for TFBS predictions require large amounts of labeled data. However, many TFs of certain cell types either do not have sufficient labeled data or do not have any labeled data.