scInterpreter: Training Large Language Models to Interpret scRNA-seq Data for Cell Type Annotation

Cong Li, Meng Xiao, Pengfei Wang, Guihai Feng, Xin Li, Yuanchun Zhou

Abstract: Despite the inherent limitations of existing Large Language Models in directly reading and interpreting single-cell omics data, they demonstrate significant potential and flexibility as the Foundation Model. This research focuses on how to train and adapt the Large Language Model with the capability to interpret and distinguish cell types in single-cell RNA sequencing data. Our preliminary research results indicate that these foundational models excel in accurately categorizing known cell types, demonstrating the potential of the Large Language Models as effective tools for uncovering new biological insights.