Multi-modal latent factor exploration of atrophy, cognitive and tau heterogeneity in Alzheimer's disease

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Nanbo Sun, Elizabeth C. Mormino, Jianzhong Chen, Mert R. Sabuncu, B. T. Thomas Yeo, Alzheimer's Disease Neuroimaging Initiative

Published: 01 Jan 2019, Last Modified: 15 May 2025NeuroImage 2019EveryoneRevisionsBibTeXCC BY-SA 4.0
Abstract: Highlights•Bayesian model reveals 3 atrophy-cognitive factors in typical AD from ADNI-GO/2.•Replicated in independent ADNI-1 cohort; longitudinally stable within individuals.•Triple cognitive dissociations among atrophy patterns suggest subtypes, not stages.•Outperforms canonical correlation analysis.•Factor loadings associated with spatial patterns of Tau uptake in MCI.