Deep learning enables accurate brain tissue microstructure analysis based on clinically feasible diffusion magnetic resonance imaging

Yuxing Li, Zhizheng Zhuo, Chenghao Liu, Yunyun Duan, Yulu Shi, Tingting Wang, Runzhi Li, Yanli Wang, Jiwei Jiang, Jun Xu, Decai Tian, Xinghu Zhang, Fudong Shi, Xiaofeng Zhang, Aaron Carass, Frederik Barkhof, Jerry L. Prince, Chuyang Ye, Yaou Liu

Abstract: Highlights•We show that deep learning allows tissue microstructure analysis in clinical settings.•The study was performed on three in-house datasets and one public dataset.•Comprehensive evaluation was performed with multiple brain diseases and signal models.•We found that deep learning preserved disease- & age-related tissue alterations.