Computational modelling in disorders of consciousness: Closing the gap towards personalised models for restoring consciousness

Andrea I. Luppi, Joana Cabral, Rodrigo Cofré, Pedro A. M. Mediano, Fernando E. Rosas, Abid Y. Qureshi, Amy Kuceyeski, Enzo Tagliazucchi, Federico Raimondo, Gustavo Deco, James M. Shine, Morten L. Kringelbach, Patricio Orio, ShiNung Ching, Yonatan Sanz Perl, Michael N. Diringer, Robert D. Stevens, Jacobo Diego Sitt

Abstract: Highlights•Overview of the wide range of modelling strategies for disorders of consciousness.•Descriptive and generative statistical models, biophysical computational models.•Gap analysis of challenges to DOC modelling and recommendations to overcome them.•Towards personalised models for diagnosis and treatment of DOC with multimodal data.•“Phase Zero” in silico clinical trials of potential treatments via brain modelling.