Probabilistic retrieval and visualization of biologically relevant microarray experiments

José Caldas, Nils Gehlenborg, Ali Faisal, Alvis Brazma, Samuel Kaski

Abstract: As ArrayExpress and other repositories of genome-wide experiments are reaching a mature size, it is becoming more meaningful to search for related experiments, given a particular study. We introduce methods that allow for the search to be based upon measurement data, instead of the more customary annotation data. The goal is to retrieve experiments in which the same biological processes are activated. This can be due either to experiments targeting the same biological question, or to as yet unknown relationships.