Deep feature extraction of single-cell transcriptomes by generative adversarial network

Mojtaba Bahrami, Malosree Maitra, Corina Nagy, Gustavo Turecki, Hamid R. Rabiee, Yue Li

Abstract: Single-cell RNA-sequencing (scRNA-seq) offers the opportunity to dissect heterogeneous cellular compositions and interrogate the cell-type-specific gene expression patterns across diverse conditions. However, batch effects such as laboratory conditions and individual-variability hinder their usage in cross-condition designs.