A powerful conditional gene-based association approach implicated functionally important genes for schizophrenia

Miao-Xin Li, Lin Jiang, Timothy Shin Heng Mak, Johnny S. H. Kwan, Chao Xue, Peikai Chen, Henry Chi-Ming Leung, Liqian Cui, Tao Li, Pak Chung Sham

Abstract: It remains challenging to unravel new susceptibility genes of complex diseases and the mechanisms in genome-wide association studies. There are at least two difficulties, isolation of the genuine susceptibility genes from many indirectly associated genes and functional validation of these genes.